-- dump date 20140619_052128 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1168865000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1168865000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865000003 Walker A motif; other site 1168865000004 ATP binding site [chemical binding]; other site 1168865000005 Walker B motif; other site 1168865000006 arginine finger; other site 1168865000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1168865000008 DnaA box-binding interface [nucleotide binding]; other site 1168865000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1168865000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1168865000011 putative DNA binding surface [nucleotide binding]; other site 1168865000012 dimer interface [polypeptide binding]; other site 1168865000013 beta-clamp/clamp loader binding surface; other site 1168865000014 beta-clamp/translesion DNA polymerase binding surface; other site 1168865000015 recombination protein F; Reviewed; Region: recF; PRK00064 1168865000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1168865000017 Walker A/P-loop; other site 1168865000018 ATP binding site [chemical binding]; other site 1168865000019 Q-loop/lid; other site 1168865000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865000021 ABC transporter signature motif; other site 1168865000022 Walker B; other site 1168865000023 D-loop; other site 1168865000024 H-loop/switch region; other site 1168865000025 hypothetical protein; Provisional; Region: PRK00111 1168865000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1168865000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865000028 ATP binding site [chemical binding]; other site 1168865000029 Mg2+ binding site [ion binding]; other site 1168865000030 G-X-G motif; other site 1168865000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1168865000032 anchoring element; other site 1168865000033 dimer interface [polypeptide binding]; other site 1168865000034 ATP binding site [chemical binding]; other site 1168865000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1168865000036 active site 1168865000037 putative metal-binding site [ion binding]; other site 1168865000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1168865000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1168865000040 metal binding site [ion binding]; metal-binding site 1168865000041 DNA gyrase subunit A; Validated; Region: PRK05560 1168865000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1168865000043 CAP-like domain; other site 1168865000044 active site 1168865000045 primary dimer interface [polypeptide binding]; other site 1168865000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168865000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168865000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168865000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168865000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168865000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168865000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1168865000053 YwiC-like protein; Region: YwiC; pfam14256 1168865000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1168865000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1168865000056 putative ligand binding site [chemical binding]; other site 1168865000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1168865000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1168865000059 TM-ABC transporter signature motif; other site 1168865000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1168865000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1168865000062 Walker A/P-loop; other site 1168865000063 ATP binding site [chemical binding]; other site 1168865000064 Q-loop/lid; other site 1168865000065 ABC transporter signature motif; other site 1168865000066 Walker B; other site 1168865000067 D-loop; other site 1168865000068 H-loop/switch region; other site 1168865000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1168865000070 active site 1168865000071 Rhomboid family; Region: Rhomboid; pfam01694 1168865000072 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1168865000073 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1168865000074 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 1168865000075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1168865000076 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 1168865000077 putative active site [active] 1168865000078 catalytic site [active] 1168865000079 Mg binding site [ion binding]; other site 1168865000080 catalytic loop [active] 1168865000081 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1168865000082 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865000083 Walker A/P-loop; other site 1168865000084 ATP binding site [chemical binding]; other site 1168865000085 Q-loop/lid; other site 1168865000086 ABC transporter signature motif; other site 1168865000087 Walker B; other site 1168865000088 D-loop; other site 1168865000089 H-loop/switch region; other site 1168865000090 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1168865000091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865000092 ABC-ATPase subunit interface; other site 1168865000093 dimer interface [polypeptide binding]; other site 1168865000094 putative PBP binding regions; other site 1168865000095 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865000096 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865000097 ABC-ATPase subunit interface; other site 1168865000098 dimer interface [polypeptide binding]; other site 1168865000099 putative PBP binding regions; other site 1168865000100 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1168865000101 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1168865000102 siderophore binding site; other site 1168865000103 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 1168865000104 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1168865000105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168865000106 active site 1168865000107 ATP binding site [chemical binding]; other site 1168865000108 substrate binding site [chemical binding]; other site 1168865000109 activation loop (A-loop); other site 1168865000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1168865000111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865000112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865000113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865000114 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865000115 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1168865000116 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168865000117 active site 1168865000118 ATP binding site [chemical binding]; other site 1168865000119 substrate binding site [chemical binding]; other site 1168865000120 activation loop (A-loop); other site 1168865000121 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168865000122 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168865000123 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1168865000124 Protein phosphatase 2C; Region: PP2C; pfam00481 1168865000125 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1168865000126 active site 1168865000127 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168865000128 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168865000129 phosphopeptide binding site; other site 1168865000130 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1168865000131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168865000132 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168865000133 phosphopeptide binding site; other site 1168865000134 CAAX protease self-immunity; Region: Abi; pfam02517 1168865000135 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1168865000136 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168865000137 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1168865000138 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1168865000139 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865000140 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1168865000141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1168865000142 Divalent cation transporter; Region: MgtE; pfam01769 1168865000143 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168865000144 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 1168865000145 active site 1168865000146 catalytic site [active] 1168865000147 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1168865000148 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1168865000149 RNA polymerase sigma factor; Provisional; Region: PRK12537 1168865000150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865000151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865000152 DNA binding residues [nucleotide binding] 1168865000153 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1168865000154 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1168865000155 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1168865000156 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168865000157 catalytic residues [active] 1168865000158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1168865000159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865000160 dimer interface [polypeptide binding]; other site 1168865000161 conserved gate region; other site 1168865000162 putative PBP binding loops; other site 1168865000163 ABC-ATPase subunit interface; other site 1168865000164 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1168865000165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865000166 Walker A/P-loop; other site 1168865000167 ATP binding site [chemical binding]; other site 1168865000168 Q-loop/lid; other site 1168865000169 ABC transporter signature motif; other site 1168865000170 Walker B; other site 1168865000171 D-loop; other site 1168865000172 H-loop/switch region; other site 1168865000173 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1168865000174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865000175 Coenzyme A binding pocket [chemical binding]; other site 1168865000176 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1168865000177 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1168865000178 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1168865000179 putative metal binding site [ion binding]; other site 1168865000180 biotin synthase; Validated; Region: PRK06256 1168865000181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865000182 FeS/SAM binding site; other site 1168865000183 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1168865000184 MepB protein; Region: MepB; cl01985 1168865000185 AMP nucleosidase; Provisional; Region: PRK08292 1168865000186 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1168865000187 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1168865000188 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1168865000189 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1168865000190 active site 1168865000191 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1168865000192 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1168865000193 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1168865000194 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1168865000195 dimer interface [polypeptide binding]; other site 1168865000196 FMN binding site [chemical binding]; other site 1168865000197 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1168865000198 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1168865000199 trimer interface [polypeptide binding]; other site 1168865000200 putative metal binding site [ion binding]; other site 1168865000201 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168865000202 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1168865000203 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1168865000204 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1168865000205 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1168865000206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865000207 Coenzyme A binding pocket [chemical binding]; other site 1168865000208 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1168865000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1168865000210 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168865000211 MarR family; Region: MarR; pfam01047 1168865000212 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1168865000213 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1168865000214 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1168865000215 hypothetical protein; Provisional; Region: PRK10621 1168865000216 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1168865000217 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1168865000218 active site 1168865000219 phosphorylation site [posttranslational modification] 1168865000220 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1168865000221 active site 1168865000222 P-loop; other site 1168865000223 phosphorylation site [posttranslational modification] 1168865000224 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1168865000225 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1168865000226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865000227 ATP binding site [chemical binding]; other site 1168865000228 putative Mg++ binding site [ion binding]; other site 1168865000229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865000230 nucleotide binding region [chemical binding]; other site 1168865000231 ATP-binding site [chemical binding]; other site 1168865000232 Helicase associated domain (HA2); Region: HA2; pfam04408 1168865000233 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1168865000234 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1168865000235 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1168865000236 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1168865000237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865000238 NAD(P) binding site [chemical binding]; other site 1168865000239 active site 1168865000240 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1168865000241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865000242 RNA binding surface [nucleotide binding]; other site 1168865000243 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1168865000244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168865000245 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1168865000246 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1168865000247 DNA binding site [nucleotide binding] 1168865000248 active site 1168865000249 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168865000250 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168865000251 active site 1168865000252 glycerol kinase; Provisional; Region: glpK; PRK00047 1168865000253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168865000254 nucleotide binding site [chemical binding]; other site 1168865000255 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1168865000256 amphipathic channel; other site 1168865000257 Asn-Pro-Ala signature motifs; other site 1168865000258 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1168865000259 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1168865000260 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1168865000261 active site 1168865000262 Zn binding site [ion binding]; other site 1168865000263 Protease prsW family; Region: PrsW-protease; pfam13367 1168865000264 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1168865000265 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1168865000266 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1168865000267 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1168865000268 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1168865000269 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168865000270 classical (c) SDRs; Region: SDR_c; cd05233 1168865000271 NAD(P) binding site [chemical binding]; other site 1168865000272 active site 1168865000273 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168865000274 FAD binding domain; Region: FAD_binding_4; pfam01565 1168865000275 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1168865000276 Predicted membrane protein [Function unknown]; Region: COG2246 1168865000277 GtrA-like protein; Region: GtrA; pfam04138 1168865000278 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865000279 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168865000280 intersubunit interface [polypeptide binding]; other site 1168865000281 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168865000282 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1168865000283 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168865000284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1168865000285 ABC-ATPase subunit interface; other site 1168865000286 dimer interface [polypeptide binding]; other site 1168865000287 putative PBP binding regions; other site 1168865000288 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168865000289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865000290 ABC-ATPase subunit interface; other site 1168865000291 dimer interface [polypeptide binding]; other site 1168865000292 putative PBP binding regions; other site 1168865000293 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865000294 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168865000295 intersubunit interface [polypeptide binding]; other site 1168865000296 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1168865000297 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1168865000298 active site 1168865000299 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1168865000300 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1168865000301 Walker A/P-loop; other site 1168865000302 ATP binding site [chemical binding]; other site 1168865000303 Q-loop/lid; other site 1168865000304 ABC transporter signature motif; other site 1168865000305 Walker B; other site 1168865000306 D-loop; other site 1168865000307 H-loop/switch region; other site 1168865000308 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1168865000309 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168865000310 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1168865000311 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168865000312 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1168865000313 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1168865000314 NAD(P) binding site [chemical binding]; other site 1168865000315 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1168865000316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865000317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865000318 homodimer interface [polypeptide binding]; other site 1168865000319 catalytic residue [active] 1168865000320 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1168865000321 transmembrane helices; other site 1168865000322 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1168865000323 CAT RNA binding domain; Region: CAT_RBD; smart01061 1168865000324 PRD domain; Region: PRD; pfam00874 1168865000325 PRD domain; Region: PRD; pfam00874 1168865000326 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1168865000327 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168865000328 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1168865000329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168865000330 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1168865000331 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1168865000332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168865000333 DNA-binding site [nucleotide binding]; DNA binding site 1168865000334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865000335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865000336 homodimer interface [polypeptide binding]; other site 1168865000337 catalytic residue [active] 1168865000338 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1168865000339 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1168865000340 active site 1168865000341 multimer interface [polypeptide binding]; other site 1168865000342 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1168865000343 predicted active site [active] 1168865000344 catalytic triad [active] 1168865000345 prephenate dehydrogenase; Validated; Region: PRK06545 1168865000346 prephenate dehydrogenase; Validated; Region: PRK08507 1168865000347 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1168865000348 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1168865000349 nucleoside/Zn binding site; other site 1168865000350 dimer interface [polypeptide binding]; other site 1168865000351 catalytic motif [active] 1168865000352 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168865000353 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1168865000354 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1168865000355 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1168865000356 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1168865000357 active site 1168865000358 KMSKS motif; other site 1168865000359 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1168865000360 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1168865000361 Shikimate kinase; Region: SKI; pfam01202 1168865000362 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1168865000363 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1168865000364 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1168865000365 putative NAD(P) binding site [chemical binding]; other site 1168865000366 catalytic Zn binding site [ion binding]; other site 1168865000367 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1168865000368 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1168865000369 NADP binding site [chemical binding]; other site 1168865000370 homodimer interface [polypeptide binding]; other site 1168865000371 active site 1168865000372 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1168865000373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865000374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865000375 homodimer interface [polypeptide binding]; other site 1168865000376 catalytic residue [active] 1168865000377 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1168865000378 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1168865000379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865000380 Walker A motif; other site 1168865000381 ATP binding site [chemical binding]; other site 1168865000382 Walker B motif; other site 1168865000383 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168865000384 arginine finger; other site 1168865000385 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1168865000386 hypothetical protein; Validated; Region: PRK00153 1168865000387 recombination protein RecR; Reviewed; Region: recR; PRK00076 1168865000388 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1168865000389 RecR protein; Region: RecR; pfam02132 1168865000390 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1168865000391 putative active site [active] 1168865000392 putative metal-binding site [ion binding]; other site 1168865000393 tetramer interface [polypeptide binding]; other site 1168865000394 putative transporter; Provisional; Region: PRK09821 1168865000395 GntP family permease; Region: GntP_permease; pfam02447 1168865000396 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1168865000397 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1168865000398 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168865000399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1168865000400 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168865000401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168865000402 DNA-binding site [nucleotide binding]; DNA binding site 1168865000403 FCD domain; Region: FCD; pfam07729 1168865000404 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1168865000405 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1168865000406 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1168865000407 catalytic triad [active] 1168865000408 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1168865000409 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865000410 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1168865000411 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1168865000412 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1168865000413 active site 1168865000414 catalytic site [active] 1168865000415 substrate binding site [chemical binding]; other site 1168865000416 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1168865000417 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1168865000418 dimer interface [polypeptide binding]; other site 1168865000419 FMN binding site [chemical binding]; other site 1168865000420 NADPH bind site [chemical binding]; other site 1168865000421 2-isopropylmalate synthase; Validated; Region: PRK03739 1168865000422 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1168865000423 active site 1168865000424 catalytic residues [active] 1168865000425 metal binding site [ion binding]; metal-binding site 1168865000426 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1168865000427 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1168865000428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865000429 DNA binding residues [nucleotide binding] 1168865000430 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1168865000431 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1168865000432 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1168865000433 intersubunit interface [polypeptide binding]; other site 1168865000434 active site 1168865000435 catalytic residue [active] 1168865000436 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1168865000437 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1168865000438 active site 1168865000439 substrate binding site [chemical binding]; other site 1168865000440 metal binding site [ion binding]; metal-binding site 1168865000441 TQXA domain; Region: TQXA_dom; TIGR03934 1168865000442 aspartate kinase; Reviewed; Region: PRK06635 1168865000443 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1168865000444 putative nucleotide binding site [chemical binding]; other site 1168865000445 putative catalytic residues [active] 1168865000446 putative Mg ion binding site [ion binding]; other site 1168865000447 putative aspartate binding site [chemical binding]; other site 1168865000448 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1168865000449 putative allosteric regulatory site; other site 1168865000450 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1168865000451 putative allosteric regulatory residue; other site 1168865000452 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1168865000453 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168865000454 RNA polymerase sigma factor; Provisional; Region: PRK12535 1168865000455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865000456 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168865000457 DNA binding residues [nucleotide binding] 1168865000458 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1168865000459 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1168865000460 heme binding pocket [chemical binding]; other site 1168865000461 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1168865000462 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1168865000463 Walker A/P-loop; other site 1168865000464 ATP binding site [chemical binding]; other site 1168865000465 Q-loop/lid; other site 1168865000466 ABC transporter signature motif; other site 1168865000467 Walker B; other site 1168865000468 D-loop; other site 1168865000469 H-loop/switch region; other site 1168865000470 TOBE domain; Region: TOBE_2; pfam08402 1168865000471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865000472 dimer interface [polypeptide binding]; other site 1168865000473 conserved gate region; other site 1168865000474 ABC-ATPase subunit interface; other site 1168865000475 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1168865000476 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1168865000477 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1168865000478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865000479 putative substrate translocation pore; other site 1168865000480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168865000481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865000482 active site 1168865000483 phosphorylation site [posttranslational modification] 1168865000484 intermolecular recognition site; other site 1168865000485 dimerization interface [polypeptide binding]; other site 1168865000486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168865000487 DNA binding site [nucleotide binding] 1168865000488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168865000489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168865000490 dimer interface [polypeptide binding]; other site 1168865000491 phosphorylation site [posttranslational modification] 1168865000492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865000493 ATP binding site [chemical binding]; other site 1168865000494 Mg2+ binding site [ion binding]; other site 1168865000495 G-X-G motif; other site 1168865000496 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1168865000497 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1168865000498 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1168865000499 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1168865000500 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168865000501 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1168865000502 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1168865000503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168865000504 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1168865000505 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1168865000506 Predicted membrane protein [Function unknown]; Region: COG1511 1168865000507 Predicted membrane protein [Function unknown]; Region: COG1511 1168865000508 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1168865000509 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1168865000510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1168865000511 putative active site [active] 1168865000512 putative metal binding site [ion binding]; other site 1168865000513 Yqey-like protein; Region: YqeY; pfam09424 1168865000514 Transglycosylase; Region: Transgly; pfam00912 1168865000515 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1168865000516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1168865000517 PASTA domain; Region: PASTA; pfam03793 1168865000518 Transcription factor WhiB; Region: Whib; pfam02467 1168865000519 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1168865000520 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1168865000521 homotrimer interaction site [polypeptide binding]; other site 1168865000522 putative active site [active] 1168865000523 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1168865000524 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168865000525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168865000526 ligand binding site [chemical binding]; other site 1168865000527 flexible hinge region; other site 1168865000528 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1168865000529 putative switch regulator; other site 1168865000530 non-specific DNA interactions [nucleotide binding]; other site 1168865000531 DNA binding site [nucleotide binding] 1168865000532 sequence specific DNA binding site [nucleotide binding]; other site 1168865000533 putative cAMP binding site [chemical binding]; other site 1168865000534 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1168865000535 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168865000536 minor groove reading motif; other site 1168865000537 helix-hairpin-helix signature motif; other site 1168865000538 substrate binding pocket [chemical binding]; other site 1168865000539 active site 1168865000540 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1168865000541 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1168865000542 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168865000543 catalytic residues [active] 1168865000544 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1168865000545 putative active site [active] 1168865000546 putative CoA binding site [chemical binding]; other site 1168865000547 nudix motif; other site 1168865000548 metal binding site [ion binding]; metal-binding site 1168865000549 Colicin V production protein; Region: Colicin_V; pfam02674 1168865000550 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1168865000551 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168865000552 active site 1168865000553 substrate binding sites [chemical binding]; other site 1168865000554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168865000555 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168865000556 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1168865000557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865000558 motif II; other site 1168865000559 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1168865000560 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1168865000561 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1168865000562 ATP binding site [chemical binding]; other site 1168865000563 Walker A motif; other site 1168865000564 hexamer interface [polypeptide binding]; other site 1168865000565 Walker B motif; other site 1168865000566 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1168865000567 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1168865000568 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1168865000569 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1168865000570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865000571 ATP binding site [chemical binding]; other site 1168865000572 putative Mg++ binding site [ion binding]; other site 1168865000573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865000574 nucleotide binding region [chemical binding]; other site 1168865000575 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1168865000576 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168865000577 DNA-binding site [nucleotide binding]; DNA binding site 1168865000578 RNA-binding motif; other site 1168865000579 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1168865000580 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1168865000581 active site 1168865000582 interdomain interaction site; other site 1168865000583 putative metal-binding site [ion binding]; other site 1168865000584 nucleotide binding site [chemical binding]; other site 1168865000585 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1168865000586 domain I; other site 1168865000587 DNA binding groove [nucleotide binding] 1168865000588 phosphate binding site [ion binding]; other site 1168865000589 domain II; other site 1168865000590 domain III; other site 1168865000591 nucleotide binding site [chemical binding]; other site 1168865000592 catalytic site [active] 1168865000593 domain IV; other site 1168865000594 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168865000595 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168865000596 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168865000597 Predicted membrane protein [Function unknown]; Region: COG1297 1168865000598 putative oligopeptide transporter, OPT family; Region: TIGR00733 1168865000599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168865000600 dimerization interface [polypeptide binding]; other site 1168865000601 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168865000602 cyclase homology domain; Region: CHD; cd07302 1168865000603 nucleotidyl binding site; other site 1168865000604 metal binding site [ion binding]; metal-binding site 1168865000605 dimer interface [polypeptide binding]; other site 1168865000606 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1168865000607 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1168865000608 acyl-CoA synthetase; Validated; Region: PRK07788 1168865000609 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865000610 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865000611 acyl-activating enzyme (AAE) consensus motif; other site 1168865000612 acyl-activating enzyme (AAE) consensus motif; other site 1168865000613 AMP binding site [chemical binding]; other site 1168865000614 active site 1168865000615 CoA binding site [chemical binding]; other site 1168865000616 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1168865000617 active site 1168865000618 catalytic triad [active] 1168865000619 oxyanion hole [active] 1168865000620 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1168865000621 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1168865000622 substrate binding site; other site 1168865000623 tetramer interface; other site 1168865000624 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1168865000625 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1168865000626 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1168865000627 NADP binding site [chemical binding]; other site 1168865000628 active site 1168865000629 putative substrate binding site [chemical binding]; other site 1168865000630 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1168865000631 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1168865000632 NAD binding site [chemical binding]; other site 1168865000633 substrate binding site [chemical binding]; other site 1168865000634 homodimer interface [polypeptide binding]; other site 1168865000635 active site 1168865000636 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1168865000637 Zn binding site [ion binding]; other site 1168865000638 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1168865000639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168865000640 Putative esterase; Region: Esterase; pfam00756 1168865000641 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1168865000642 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168865000643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168865000644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168865000645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168865000646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168865000647 non-specific DNA binding site [nucleotide binding]; other site 1168865000648 salt bridge; other site 1168865000649 sequence-specific DNA binding site [nucleotide binding]; other site 1168865000650 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1168865000651 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1168865000652 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1168865000653 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1168865000654 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1168865000655 putative Iron-sulfur protein interface [polypeptide binding]; other site 1168865000656 proximal heme binding site [chemical binding]; other site 1168865000657 distal heme binding site [chemical binding]; other site 1168865000658 putative dimer interface [polypeptide binding]; other site 1168865000659 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1168865000660 L-aspartate oxidase; Provisional; Region: PRK06175 1168865000661 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1168865000662 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1168865000663 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1168865000664 Predicted membrane protein [Function unknown]; Region: COG2733 1168865000665 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1168865000666 Class I aldolases; Region: Aldolase_Class_I; cl17187 1168865000667 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1168865000668 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1168865000669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865000670 FeS/SAM binding site; other site 1168865000671 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1168865000672 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1168865000673 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1168865000674 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1168865000675 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1168865000676 FAD binding domain; Region: FAD_binding_4; pfam01565 1168865000677 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1168865000678 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1168865000679 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1168865000680 acyl-activating enzyme (AAE) consensus motif; other site 1168865000681 putative AMP binding site [chemical binding]; other site 1168865000682 putative active site [active] 1168865000683 putative CoA binding site [chemical binding]; other site 1168865000684 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1168865000685 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1168865000686 putative ADP-binding pocket [chemical binding]; other site 1168865000687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865000688 catalytic core [active] 1168865000689 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865000690 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1168865000691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168865000692 dimer interface [polypeptide binding]; other site 1168865000693 phosphorylation site [posttranslational modification] 1168865000694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865000695 ATP binding site [chemical binding]; other site 1168865000696 Mg2+ binding site [ion binding]; other site 1168865000697 G-X-G motif; other site 1168865000698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168865000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865000700 active site 1168865000701 phosphorylation site [posttranslational modification] 1168865000702 intermolecular recognition site; other site 1168865000703 dimerization interface [polypeptide binding]; other site 1168865000704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168865000705 DNA binding site [nucleotide binding] 1168865000706 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1168865000707 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1168865000708 DNA binding domain, excisionase family; Region: excise; TIGR01764 1168865000709 Thioredoxin; Region: Thioredoxin_4; cl17273 1168865000710 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1168865000711 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1168865000712 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1168865000713 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1168865000714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865000715 motif II; other site 1168865000716 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1168865000717 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1168865000718 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1168865000719 tRNA; other site 1168865000720 putative tRNA binding site [nucleotide binding]; other site 1168865000721 putative NADP binding site [chemical binding]; other site 1168865000722 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1168865000723 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1168865000724 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1168865000725 domain interfaces; other site 1168865000726 active site 1168865000727 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1168865000728 active site 1168865000729 homodimer interface [polypeptide binding]; other site 1168865000730 SAM binding site [chemical binding]; other site 1168865000731 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1168865000732 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1168865000733 active site 1168865000734 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1168865000735 dimer interface [polypeptide binding]; other site 1168865000736 active site 1168865000737 Schiff base residues; other site 1168865000738 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168865000739 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1168865000740 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1168865000741 substrate binding site [chemical binding]; other site 1168865000742 active site 1168865000743 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1168865000744 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1168865000745 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168865000746 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1168865000747 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168865000748 inhibitor-cofactor binding pocket; inhibition site 1168865000749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865000750 catalytic residue [active] 1168865000751 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865000752 catalytic core [active] 1168865000753 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1168865000754 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168865000755 catalytic residues [active] 1168865000756 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1168865000757 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1168865000758 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1168865000759 ResB-like family; Region: ResB; pfam05140 1168865000760 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168865000761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865000762 S-adenosylmethionine binding site [chemical binding]; other site 1168865000763 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1168865000764 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865000765 Walker A/P-loop; other site 1168865000766 ATP binding site [chemical binding]; other site 1168865000767 Q-loop/lid; other site 1168865000768 ABC transporter signature motif; other site 1168865000769 Walker B; other site 1168865000770 D-loop; other site 1168865000771 H-loop/switch region; other site 1168865000772 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1168865000773 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865000774 intersubunit interface [polypeptide binding]; other site 1168865000775 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1168865000776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865000777 ABC-ATPase subunit interface; other site 1168865000778 dimer interface [polypeptide binding]; other site 1168865000779 putative PBP binding regions; other site 1168865000780 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1168865000781 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1168865000782 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1168865000783 UbiA prenyltransferase family; Region: UbiA; pfam01040 1168865000784 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1168865000785 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865000786 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865000787 acyl-activating enzyme (AAE) consensus motif; other site 1168865000788 acyl-activating enzyme (AAE) consensus motif; other site 1168865000789 AMP binding site [chemical binding]; other site 1168865000790 active site 1168865000791 CoA binding site [chemical binding]; other site 1168865000792 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1168865000793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168865000794 substrate binding site [chemical binding]; other site 1168865000795 oxyanion hole (OAH) forming residues; other site 1168865000796 trimer interface [polypeptide binding]; other site 1168865000797 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1168865000798 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1168865000799 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1168865000800 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1168865000801 active site 1168865000802 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1168865000803 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1168865000804 dimer interface [polypeptide binding]; other site 1168865000805 tetramer interface [polypeptide binding]; other site 1168865000806 PYR/PP interface [polypeptide binding]; other site 1168865000807 TPP binding site [chemical binding]; other site 1168865000808 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1168865000809 TPP-binding site; other site 1168865000810 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1168865000811 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1168865000812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168865000813 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1168865000814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865000815 S-adenosylmethionine binding site [chemical binding]; other site 1168865000816 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1168865000817 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1168865000818 NAD(P) binding site [chemical binding]; other site 1168865000819 LDH/MDH dimer interface [polypeptide binding]; other site 1168865000820 substrate binding site [chemical binding]; other site 1168865000821 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1168865000822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168865000823 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1168865000824 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1168865000825 substrate binding pocket [chemical binding]; other site 1168865000826 chain length determination region; other site 1168865000827 substrate-Mg2+ binding site; other site 1168865000828 catalytic residues [active] 1168865000829 aspartate-rich region 1; other site 1168865000830 active site lid residues [active] 1168865000831 aspartate-rich region 2; other site 1168865000832 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1168865000833 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1168865000834 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1168865000835 putative homodimer interface [polypeptide binding]; other site 1168865000836 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1168865000837 heterodimer interface [polypeptide binding]; other site 1168865000838 homodimer interface [polypeptide binding]; other site 1168865000839 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1168865000840 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1168865000841 23S rRNA interface [nucleotide binding]; other site 1168865000842 L7/L12 interface [polypeptide binding]; other site 1168865000843 putative thiostrepton binding site; other site 1168865000844 L25 interface [polypeptide binding]; other site 1168865000845 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1168865000846 mRNA/rRNA interface [nucleotide binding]; other site 1168865000847 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1168865000848 trimer interface [polypeptide binding]; other site 1168865000849 active site 1168865000850 G bulge; other site 1168865000851 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1168865000852 trimer interface [polypeptide binding]; other site 1168865000853 active site 1168865000854 G bulge; other site 1168865000855 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1168865000856 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1168865000857 FMN binding site [chemical binding]; other site 1168865000858 active site 1168865000859 substrate binding site [chemical binding]; other site 1168865000860 catalytic residue [active] 1168865000861 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1168865000862 23S rRNA interface [nucleotide binding]; other site 1168865000863 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1168865000864 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 1168865000865 L11 interface [polypeptide binding]; other site 1168865000866 putative EF-Tu interaction site [polypeptide binding]; other site 1168865000867 putative EF-G interaction site [polypeptide binding]; other site 1168865000868 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865000869 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1168865000870 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865000871 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865000872 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865000873 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865000874 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1168865000875 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1168865000876 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1168865000877 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168865000878 ABC-ATPase subunit interface; other site 1168865000879 dimer interface [polypeptide binding]; other site 1168865000880 putative PBP binding regions; other site 1168865000881 Ethylene insensitive 3; Region: EIN3; cl04813 1168865000882 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1168865000883 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1168865000884 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1168865000885 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1168865000886 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1168865000887 RPB1 interaction site [polypeptide binding]; other site 1168865000888 RPB10 interaction site [polypeptide binding]; other site 1168865000889 RPB11 interaction site [polypeptide binding]; other site 1168865000890 RPB3 interaction site [polypeptide binding]; other site 1168865000891 RPB12 interaction site [polypeptide binding]; other site 1168865000892 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1168865000893 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1168865000894 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1168865000895 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1168865000896 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1168865000897 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1168865000898 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1168865000899 G-loop; other site 1168865000900 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1168865000901 DNA binding site [nucleotide binding] 1168865000902 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1168865000903 Histidine kinase; Region: HisKA_3; pfam07730 1168865000904 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168865000905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168865000906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865000907 active site 1168865000908 phosphorylation site [posttranslational modification] 1168865000909 intermolecular recognition site; other site 1168865000910 dimerization interface [polypeptide binding]; other site 1168865000911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168865000912 DNA binding residues [nucleotide binding] 1168865000913 dimerization interface [polypeptide binding]; other site 1168865000914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168865000915 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1168865000916 Walker A/P-loop; other site 1168865000917 ATP binding site [chemical binding]; other site 1168865000918 Q-loop/lid; other site 1168865000919 ABC transporter signature motif; other site 1168865000920 Walker B; other site 1168865000921 D-loop; other site 1168865000922 H-loop/switch region; other site 1168865000923 TIGR03943 family protein; Region: TIGR03943 1168865000924 Predicted permease; Region: DUF318; cl17795 1168865000925 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1168865000926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865000927 FeS/SAM binding site; other site 1168865000928 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1168865000929 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1168865000930 effector binding site; other site 1168865000931 active site 1168865000932 Zn binding site [ion binding]; other site 1168865000933 glycine loop; other site 1168865000934 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1168865000935 S17 interaction site [polypeptide binding]; other site 1168865000936 S8 interaction site; other site 1168865000937 16S rRNA interaction site [nucleotide binding]; other site 1168865000938 streptomycin interaction site [chemical binding]; other site 1168865000939 23S rRNA interaction site [nucleotide binding]; other site 1168865000940 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1168865000941 30S ribosomal protein S7; Validated; Region: PRK05302 1168865000942 elongation factor G; Reviewed; Region: PRK00007 1168865000943 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1168865000944 G1 box; other site 1168865000945 putative GEF interaction site [polypeptide binding]; other site 1168865000946 GTP/Mg2+ binding site [chemical binding]; other site 1168865000947 Switch I region; other site 1168865000948 G2 box; other site 1168865000949 G3 box; other site 1168865000950 Switch II region; other site 1168865000951 G4 box; other site 1168865000952 G5 box; other site 1168865000953 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1168865000954 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1168865000955 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1168865000956 elongation factor Tu; Reviewed; Region: PRK00049 1168865000957 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1168865000958 G1 box; other site 1168865000959 GEF interaction site [polypeptide binding]; other site 1168865000960 GTP/Mg2+ binding site [chemical binding]; other site 1168865000961 Switch I region; other site 1168865000962 G2 box; other site 1168865000963 G3 box; other site 1168865000964 Switch II region; other site 1168865000965 G4 box; other site 1168865000966 G5 box; other site 1168865000967 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1168865000968 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1168865000969 Antibiotic Binding Site [chemical binding]; other site 1168865000970 Asp23 family; Region: Asp23; cl00574 1168865000971 Asp23 family; Region: Asp23; cl00574 1168865000972 Asp23 family; Region: Asp23; pfam03780 1168865000973 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1168865000974 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1168865000975 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1168865000976 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1168865000977 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1168865000978 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1168865000979 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1168865000980 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1168865000981 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1168865000982 putative translocon binding site; other site 1168865000983 protein-rRNA interface [nucleotide binding]; other site 1168865000984 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1168865000985 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1168865000986 G-X-X-G motif; other site 1168865000987 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1168865000988 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1168865000989 23S rRNA interface [nucleotide binding]; other site 1168865000990 5S rRNA interface [nucleotide binding]; other site 1168865000991 putative antibiotic binding site [chemical binding]; other site 1168865000992 L25 interface [polypeptide binding]; other site 1168865000993 L27 interface [polypeptide binding]; other site 1168865000994 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1168865000995 putative translocon interaction site; other site 1168865000996 23S rRNA interface [nucleotide binding]; other site 1168865000997 signal recognition particle (SRP54) interaction site; other site 1168865000998 L23 interface [polypeptide binding]; other site 1168865000999 trigger factor interaction site; other site 1168865001000 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1168865001001 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1168865001002 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168865001003 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1168865001004 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865001005 Walker A/P-loop; other site 1168865001006 ATP binding site [chemical binding]; other site 1168865001007 Q-loop/lid; other site 1168865001008 ABC transporter signature motif; other site 1168865001009 Walker B; other site 1168865001010 D-loop; other site 1168865001011 H-loop/switch region; other site 1168865001012 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865001013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865001014 Walker A/P-loop; other site 1168865001015 ATP binding site [chemical binding]; other site 1168865001016 Q-loop/lid; other site 1168865001017 ABC transporter signature motif; other site 1168865001018 Walker B; other site 1168865001019 D-loop; other site 1168865001020 H-loop/switch region; other site 1168865001021 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865001022 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1168865001023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001024 dimer interface [polypeptide binding]; other site 1168865001025 conserved gate region; other site 1168865001026 putative PBP binding loops; other site 1168865001027 ABC-ATPase subunit interface; other site 1168865001028 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865001029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001030 putative PBP binding loops; other site 1168865001031 dimer interface [polypeptide binding]; other site 1168865001032 ABC-ATPase subunit interface; other site 1168865001033 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1168865001034 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1168865001035 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1168865001036 RNA binding site [nucleotide binding]; other site 1168865001037 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1168865001038 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1168865001039 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1168865001040 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1168865001041 serine transporter; Region: stp; TIGR00814 1168865001042 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1168865001043 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1168865001044 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1168865001045 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1168865001046 active site 1168865001047 homotetramer interface [polypeptide binding]; other site 1168865001048 homodimer interface [polypeptide binding]; other site 1168865001049 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1168865001050 dimer interface [polypeptide binding]; other site 1168865001051 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1168865001052 putative functional site; other site 1168865001053 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 1168865001054 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1168865001055 ATP binding site [chemical binding]; other site 1168865001056 substrate interface [chemical binding]; other site 1168865001057 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1168865001058 active site residue [active] 1168865001059 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1168865001060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865001061 FeS/SAM binding site; other site 1168865001062 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1168865001063 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1168865001064 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1168865001065 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1168865001066 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1168865001067 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1168865001068 5S rRNA interface [nucleotide binding]; other site 1168865001069 23S rRNA interface [nucleotide binding]; other site 1168865001070 L5 interface [polypeptide binding]; other site 1168865001071 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1168865001072 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1168865001073 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1168865001074 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1168865001075 23S rRNA binding site [nucleotide binding]; other site 1168865001076 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1168865001077 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1168865001078 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168865001079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001080 dimer interface [polypeptide binding]; other site 1168865001081 conserved gate region; other site 1168865001082 putative PBP binding loops; other site 1168865001083 ABC-ATPase subunit interface; other site 1168865001084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168865001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001086 dimer interface [polypeptide binding]; other site 1168865001087 conserved gate region; other site 1168865001088 putative PBP binding loops; other site 1168865001089 ABC-ATPase subunit interface; other site 1168865001090 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1168865001091 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1168865001092 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1168865001093 Walker A/P-loop; other site 1168865001094 ATP binding site [chemical binding]; other site 1168865001095 Q-loop/lid; other site 1168865001096 ABC transporter signature motif; other site 1168865001097 Walker B; other site 1168865001098 D-loop; other site 1168865001099 H-loop/switch region; other site 1168865001100 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1168865001101 SecY translocase; Region: SecY; pfam00344 1168865001102 adenylate kinase; Reviewed; Region: adk; PRK00279 1168865001103 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1168865001104 AMP-binding site [chemical binding]; other site 1168865001105 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1168865001106 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1168865001107 active site 1168865001108 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168865001109 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1168865001110 rRNA binding site [nucleotide binding]; other site 1168865001111 predicted 30S ribosome binding site; other site 1168865001112 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1168865001113 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1168865001114 30S ribosomal protein S11; Validated; Region: PRK05309 1168865001115 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1168865001116 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1168865001117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865001118 RNA binding surface [nucleotide binding]; other site 1168865001119 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1168865001120 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1168865001121 alphaNTD - beta interaction site [polypeptide binding]; other site 1168865001122 alphaNTD homodimer interface [polypeptide binding]; other site 1168865001123 alphaNTD - beta' interaction site [polypeptide binding]; other site 1168865001124 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1168865001125 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1168865001126 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1168865001127 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1168865001128 dimerization interface 3.5A [polypeptide binding]; other site 1168865001129 active site 1168865001130 Protein of unknown function (DUF690); Region: DUF690; cl04939 1168865001131 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1168865001132 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1168865001133 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1168865001134 active site 1168865001135 catalytic residues [active] 1168865001136 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1168865001137 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1168865001138 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168865001139 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1168865001140 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168865001141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865001142 Walker A/P-loop; other site 1168865001143 ATP binding site [chemical binding]; other site 1168865001144 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1168865001145 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1168865001146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1168865001147 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1168865001148 23S rRNA interface [nucleotide binding]; other site 1168865001149 L3 interface [polypeptide binding]; other site 1168865001150 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1168865001151 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1168865001152 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1168865001153 active site 1168865001154 substrate binding site [chemical binding]; other site 1168865001155 metal binding site [ion binding]; metal-binding site 1168865001156 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 1168865001157 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1168865001158 alanine racemase; Reviewed; Region: alr; PRK00053 1168865001159 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1168865001160 active site 1168865001161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168865001162 dimer interface [polypeptide binding]; other site 1168865001163 substrate binding site [chemical binding]; other site 1168865001164 catalytic residues [active] 1168865001165 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1168865001166 Predicted permease [General function prediction only]; Region: COG2985 1168865001167 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1168865001168 TrkA-C domain; Region: TrkA_C; pfam02080 1168865001169 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1168865001170 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1168865001171 Glycoprotease family; Region: Peptidase_M22; pfam00814 1168865001172 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1168865001173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865001174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168865001175 Coenzyme A binding pocket [chemical binding]; other site 1168865001176 UGMP family protein; Validated; Region: PRK09604 1168865001177 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1168865001178 oligomerisation interface [polypeptide binding]; other site 1168865001179 mobile loop; other site 1168865001180 roof hairpin; other site 1168865001181 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1168865001182 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1168865001183 ring oligomerisation interface [polypeptide binding]; other site 1168865001184 ATP/Mg binding site [chemical binding]; other site 1168865001185 stacking interactions; other site 1168865001186 hinge regions; other site 1168865001187 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1168865001188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865001189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865001190 DNA binding residues [nucleotide binding] 1168865001191 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1168865001192 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168865001193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1168865001194 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1168865001195 active site 1168865001196 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1168865001197 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168865001198 phosphate binding site [ion binding]; other site 1168865001199 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1168865001200 GMP synthase; Reviewed; Region: guaA; PRK00074 1168865001201 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1168865001202 AMP/PPi binding site [chemical binding]; other site 1168865001203 candidate oxyanion hole; other site 1168865001204 catalytic triad [active] 1168865001205 potential glutamine specificity residues [chemical binding]; other site 1168865001206 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1168865001207 ATP Binding subdomain [chemical binding]; other site 1168865001208 Ligand Binding sites [chemical binding]; other site 1168865001209 Dimerization subdomain; other site 1168865001210 PspC domain; Region: PspC; cl00864 1168865001211 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1168865001212 PspC domain; Region: PspC; pfam04024 1168865001213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168865001214 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168865001215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168865001216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865001217 active site 1168865001218 phosphorylation site [posttranslational modification] 1168865001219 intermolecular recognition site; other site 1168865001220 dimerization interface [polypeptide binding]; other site 1168865001221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168865001222 dimerization interface [polypeptide binding]; other site 1168865001223 DNA binding residues [nucleotide binding] 1168865001224 AMIN domain; Region: AMIN; pfam11741 1168865001225 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1168865001226 putative dimer interface [polypeptide binding]; other site 1168865001227 putative [2Fe-2S] cluster binding site [ion binding]; other site 1168865001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001229 dimer interface [polypeptide binding]; other site 1168865001230 conserved gate region; other site 1168865001231 ABC-ATPase subunit interface; other site 1168865001232 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1168865001233 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1168865001234 Walker A/P-loop; other site 1168865001235 ATP binding site [chemical binding]; other site 1168865001236 Q-loop/lid; other site 1168865001237 ABC transporter signature motif; other site 1168865001238 Walker B; other site 1168865001239 D-loop; other site 1168865001240 H-loop/switch region; other site 1168865001241 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1168865001242 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1168865001243 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1168865001244 Equine arteritis virus serine endopeptidase S32; Region: Peptidase_S32; pfam05579 1168865001245 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865001246 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168865001247 intersubunit interface [polypeptide binding]; other site 1168865001248 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168865001249 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1168865001250 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168865001251 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865001252 ABC-ATPase subunit interface; other site 1168865001253 dimer interface [polypeptide binding]; other site 1168865001254 putative PBP binding regions; other site 1168865001255 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168865001256 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1168865001257 ABC-ATPase subunit interface; other site 1168865001258 dimer interface [polypeptide binding]; other site 1168865001259 putative PBP binding regions; other site 1168865001260 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1168865001261 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1168865001262 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1168865001263 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1168865001264 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1168865001265 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1168865001266 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1168865001267 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1168865001268 homodimer interface [polypeptide binding]; other site 1168865001269 NADP binding site [chemical binding]; other site 1168865001270 substrate binding site [chemical binding]; other site 1168865001271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168865001272 active site 1168865001273 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1168865001274 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1168865001275 Htaa; Region: HtaA; pfam04213 1168865001276 Htaa; Region: HtaA; pfam04213 1168865001277 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1168865001278 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865001279 intersubunit interface [polypeptide binding]; other site 1168865001280 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865001281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865001282 ABC-ATPase subunit interface; other site 1168865001283 dimer interface [polypeptide binding]; other site 1168865001284 putative PBP binding regions; other site 1168865001285 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1168865001286 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865001287 Walker A/P-loop; other site 1168865001288 ATP binding site [chemical binding]; other site 1168865001289 Q-loop/lid; other site 1168865001290 ABC transporter signature motif; other site 1168865001291 Walker B; other site 1168865001292 D-loop; other site 1168865001293 H-loop/switch region; other site 1168865001294 Htaa; Region: HtaA; pfam04213 1168865001295 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1168865001296 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168865001297 homodimer interface [polypeptide binding]; other site 1168865001298 substrate-cofactor binding pocket; other site 1168865001299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865001300 catalytic residue [active] 1168865001301 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1168865001302 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1168865001303 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1168865001304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865001305 putative substrate translocation pore; other site 1168865001306 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1168865001307 putative catalytic site [active] 1168865001308 putative metal binding site [ion binding]; other site 1168865001309 putative phosphate binding site [ion binding]; other site 1168865001310 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1168865001311 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1168865001312 active site 1168865001313 HIGH motif; other site 1168865001314 dimer interface [polypeptide binding]; other site 1168865001315 KMSKS motif; other site 1168865001316 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1168865001317 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1168865001318 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1168865001319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168865001320 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168865001321 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168865001322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865001323 active site 1168865001324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168865001325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168865001326 non-specific DNA binding site [nucleotide binding]; other site 1168865001327 salt bridge; other site 1168865001328 sequence-specific DNA binding site [nucleotide binding]; other site 1168865001329 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1168865001330 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1168865001331 active site 1168865001332 substrate binding site [chemical binding]; other site 1168865001333 metal binding site [ion binding]; metal-binding site 1168865001334 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1168865001335 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1168865001336 metal binding site [ion binding]; metal-binding site 1168865001337 putative dimer interface [polypeptide binding]; other site 1168865001338 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1168865001339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168865001340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168865001341 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168865001342 pyruvate carboxylase; Reviewed; Region: PRK12999 1168865001343 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168865001344 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168865001345 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168865001346 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1168865001347 active site 1168865001348 catalytic residues [active] 1168865001349 metal binding site [ion binding]; metal-binding site 1168865001350 homodimer binding site [polypeptide binding]; other site 1168865001351 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168865001352 carboxyltransferase (CT) interaction site; other site 1168865001353 biotinylation site [posttranslational modification]; other site 1168865001354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168865001355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865001357 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1168865001358 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168865001359 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1168865001360 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168865001361 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168865001362 carboxyltransferase (CT) interaction site; other site 1168865001363 biotinylation site [posttranslational modification]; other site 1168865001364 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1168865001365 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1168865001366 active site residue [active] 1168865001367 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1168865001368 active site residue [active] 1168865001369 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168865001370 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1168865001371 Maf-like protein; Region: Maf; pfam02545 1168865001372 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1168865001373 active site 1168865001374 dimer interface [polypeptide binding]; other site 1168865001375 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1168865001376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168865001377 substrate binding site [chemical binding]; other site 1168865001378 ATP binding site [chemical binding]; other site 1168865001379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168865001380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168865001381 DNA binding site [nucleotide binding] 1168865001382 domain linker motif; other site 1168865001383 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1168865001384 putative ligand binding site [chemical binding]; other site 1168865001385 dimerization interface [polypeptide binding]; other site 1168865001386 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1168865001387 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168865001388 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168865001389 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168865001390 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168865001391 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168865001392 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168865001393 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1168865001394 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1168865001395 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1168865001396 ATP-grasp domain; Region: ATP-grasp; pfam02222 1168865001397 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1168865001398 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1168865001399 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1168865001400 putative active site [active] 1168865001401 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168865001402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001403 dimer interface [polypeptide binding]; other site 1168865001404 conserved gate region; other site 1168865001405 putative PBP binding loops; other site 1168865001406 ABC-ATPase subunit interface; other site 1168865001407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001408 dimer interface [polypeptide binding]; other site 1168865001409 conserved gate region; other site 1168865001410 putative PBP binding loops; other site 1168865001411 ABC-ATPase subunit interface; other site 1168865001412 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1168865001413 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168865001414 TIGR03089 family protein; Region: TIGR03089 1168865001415 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1168865001416 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168865001417 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168865001418 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1168865001419 Probable Catalytic site; other site 1168865001420 metal-binding site 1168865001421 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1168865001422 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1168865001423 active site 1168865001424 Substrate binding site; other site 1168865001425 Mg++ binding site; other site 1168865001426 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168865001427 putative trimer interface [polypeptide binding]; other site 1168865001428 putative CoA binding site [chemical binding]; other site 1168865001429 Transcription factor WhiB; Region: Whib; pfam02467 1168865001430 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1168865001431 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1168865001432 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1168865001433 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1168865001434 active site 1168865001435 substrate binding site [chemical binding]; other site 1168865001436 metal binding site [ion binding]; metal-binding site 1168865001437 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1168865001438 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1168865001439 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1168865001440 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1168865001441 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1168865001442 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1168865001443 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1168865001444 homotetramer interface [polypeptide binding]; other site 1168865001445 ligand binding site [chemical binding]; other site 1168865001446 catalytic site [active] 1168865001447 NAD binding site [chemical binding]; other site 1168865001448 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1168865001449 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1168865001450 TMP-binding site; other site 1168865001451 ATP-binding site [chemical binding]; other site 1168865001452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168865001453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865001454 active site 1168865001455 phosphorylation site [posttranslational modification] 1168865001456 intermolecular recognition site; other site 1168865001457 dimerization interface [polypeptide binding]; other site 1168865001458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168865001459 DNA binding site [nucleotide binding] 1168865001460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168865001461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168865001462 dimerization interface [polypeptide binding]; other site 1168865001463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168865001464 dimer interface [polypeptide binding]; other site 1168865001465 phosphorylation site [posttranslational modification] 1168865001466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865001467 ATP binding site [chemical binding]; other site 1168865001468 Mg2+ binding site [ion binding]; other site 1168865001469 G-X-G motif; other site 1168865001470 lipoprotein LpqB; Provisional; Region: PRK13616 1168865001471 Sporulation and spore germination; Region: Germane; pfam10646 1168865001472 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1168865001473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865001474 active site 1168865001475 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1168865001476 30S subunit binding site; other site 1168865001477 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1168865001478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168865001479 ATP binding site [chemical binding]; other site 1168865001480 putative Mg++ binding site [ion binding]; other site 1168865001481 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1168865001482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1168865001483 nucleotide binding region [chemical binding]; other site 1168865001484 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1168865001485 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1168865001486 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1168865001487 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168865001488 FAD binding pocket [chemical binding]; other site 1168865001489 FAD binding motif [chemical binding]; other site 1168865001490 phosphate binding motif [ion binding]; other site 1168865001491 beta-alpha-beta structure motif; other site 1168865001492 NAD binding pocket [chemical binding]; other site 1168865001493 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1168865001494 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168865001495 catalytic loop [active] 1168865001496 iron binding site [ion binding]; other site 1168865001497 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1168865001498 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1168865001499 putative di-iron ligands [ion binding]; other site 1168865001500 Predicted GTPases [General function prediction only]; Region: COG1162 1168865001501 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1168865001502 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1168865001503 GTP/Mg2+ binding site [chemical binding]; other site 1168865001504 G4 box; other site 1168865001505 G5 box; other site 1168865001506 G1 box; other site 1168865001507 Switch I region; other site 1168865001508 G2 box; other site 1168865001509 G3 box; other site 1168865001510 Switch II region; other site 1168865001511 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1168865001512 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1168865001513 hinge; other site 1168865001514 active site 1168865001515 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1168865001516 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1168865001517 putative deacylase active site [active] 1168865001518 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1168865001519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865001520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865001521 DNA binding residues [nucleotide binding] 1168865001522 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1168865001523 Transcription factor WhiB; Region: Whib; pfam02467 1168865001524 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1168865001525 active site 1168865001526 catalytic triad [active] 1168865001527 oxyanion hole [active] 1168865001528 PQQ-like domain; Region: PQQ_2; pfam13360 1168865001529 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1168865001530 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168865001531 ATP binding site [chemical binding]; other site 1168865001532 Mg++ binding site [ion binding]; other site 1168865001533 motif III; other site 1168865001534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865001535 nucleotide binding region [chemical binding]; other site 1168865001536 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1168865001537 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1168865001538 TIGR02569 family protein; Region: TIGR02569_actnb 1168865001539 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168865001540 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168865001541 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168865001542 Part of AAA domain; Region: AAA_19; pfam13245 1168865001543 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168865001544 Ion channel; Region: Ion_trans_2; pfam07885 1168865001545 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1168865001546 TrkA-N domain; Region: TrkA_N; pfam02254 1168865001547 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1168865001548 putative NADH binding site [chemical binding]; other site 1168865001549 putative active site [active] 1168865001550 nudix motif; other site 1168865001551 putative metal binding site [ion binding]; other site 1168865001552 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1168865001553 Part of AAA domain; Region: AAA_19; pfam13245 1168865001554 Family description; Region: UvrD_C_2; pfam13538 1168865001555 HRDC domain; Region: HRDC; pfam00570 1168865001556 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1168865001557 Protein of unknown function DUF45; Region: DUF45; cl00636 1168865001558 putative hydrolase; Region: TIGR03624 1168865001559 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1168865001560 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1168865001561 hypothetical protein; Validated; Region: PRK00068 1168865001562 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1168865001563 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 1168865001564 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1168865001565 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1168865001566 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1168865001567 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1168865001568 Predicted membrane protein [Function unknown]; Region: COG2311 1168865001569 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1168865001570 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865001571 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168865001572 acyl-activating enzyme (AAE) consensus motif; other site 1168865001573 AMP binding site [chemical binding]; other site 1168865001574 active site 1168865001575 CoA binding site [chemical binding]; other site 1168865001576 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168865001577 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1168865001578 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168865001579 putative trimer interface [polypeptide binding]; other site 1168865001580 putative CoA binding site [chemical binding]; other site 1168865001581 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168865001582 putative trimer interface [polypeptide binding]; other site 1168865001583 putative CoA binding site [chemical binding]; other site 1168865001584 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168865001585 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1168865001586 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1168865001587 active site 1168865001588 catalytic residues [active] 1168865001589 metal binding site [ion binding]; metal-binding site 1168865001590 homodimer binding site [polypeptide binding]; other site 1168865001591 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1168865001592 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168865001593 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168865001594 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168865001595 carboxyltransferase (CT) interaction site; other site 1168865001596 biotinylation site [posttranslational modification]; other site 1168865001597 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168865001598 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1168865001599 active site 1168865001600 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1168865001601 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168865001602 active site 1168865001603 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1168865001604 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1168865001605 RF-1 domain; Region: RF-1; pfam00472 1168865001606 topology modulation protein; Provisional; Region: PRK07261 1168865001607 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1168865001608 active site 1168865001609 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1168865001610 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1168865001611 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1168865001612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865001613 Walker A/P-loop; other site 1168865001614 ATP binding site [chemical binding]; other site 1168865001615 Q-loop/lid; other site 1168865001616 ABC transporter signature motif; other site 1168865001617 Walker B; other site 1168865001618 D-loop; other site 1168865001619 H-loop/switch region; other site 1168865001620 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1168865001621 FtsX-like permease family; Region: FtsX; pfam02687 1168865001622 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1168865001623 SmpB-tmRNA interface; other site 1168865001624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1168865001625 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 1168865001626 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1168865001627 active site clefts [active] 1168865001628 zinc binding site [ion binding]; other site 1168865001629 dimer interface [polypeptide binding]; other site 1168865001630 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1168865001631 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865001632 intersubunit interface [polypeptide binding]; other site 1168865001633 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865001634 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865001635 ABC-ATPase subunit interface; other site 1168865001636 dimer interface [polypeptide binding]; other site 1168865001637 putative PBP binding regions; other site 1168865001638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865001639 ABC-ATPase subunit interface; other site 1168865001640 dimer interface [polypeptide binding]; other site 1168865001641 putative PBP binding regions; other site 1168865001642 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1168865001643 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865001644 Walker A/P-loop; other site 1168865001645 ATP binding site [chemical binding]; other site 1168865001646 Q-loop/lid; other site 1168865001647 ABC transporter signature motif; other site 1168865001648 Walker B; other site 1168865001649 D-loop; other site 1168865001650 H-loop/switch region; other site 1168865001651 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1168865001652 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1168865001653 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1168865001654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865001655 ATP binding site [chemical binding]; other site 1168865001656 putative Mg++ binding site [ion binding]; other site 1168865001657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865001658 nucleotide binding region [chemical binding]; other site 1168865001659 ATP-binding site [chemical binding]; other site 1168865001660 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1168865001661 WYL domain; Region: WYL; cl14852 1168865001662 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168865001663 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1168865001664 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168865001665 DNA-binding site [nucleotide binding]; DNA binding site 1168865001666 RNA-binding motif; other site 1168865001667 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1168865001668 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1168865001669 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1168865001670 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168865001671 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168865001672 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1168865001673 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168865001674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168865001675 catalytic residue [active] 1168865001676 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1168865001677 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1168865001678 dimer interface [polypeptide binding]; other site 1168865001679 active site 1168865001680 citrylCoA binding site [chemical binding]; other site 1168865001681 NADH binding [chemical binding]; other site 1168865001682 cationic pore residues; other site 1168865001683 oxalacetate/citrate binding site [chemical binding]; other site 1168865001684 coenzyme A binding site [chemical binding]; other site 1168865001685 catalytic triad [active] 1168865001686 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168865001687 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1168865001688 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168865001689 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1168865001690 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1168865001691 E-class dimer interface [polypeptide binding]; other site 1168865001692 P-class dimer interface [polypeptide binding]; other site 1168865001693 active site 1168865001694 Cu2+ binding site [ion binding]; other site 1168865001695 Zn2+ binding site [ion binding]; other site 1168865001696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168865001697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168865001698 active site 1168865001699 catalytic tetrad [active] 1168865001700 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168865001701 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168865001702 substrate binding site [chemical binding]; other site 1168865001703 oxyanion hole (OAH) forming residues; other site 1168865001704 trimer interface [polypeptide binding]; other site 1168865001705 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1168865001706 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1168865001707 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1168865001708 Na binding site [ion binding]; other site 1168865001709 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1168865001710 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1168865001711 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1168865001712 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1168865001713 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1168865001714 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1168865001715 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1168865001716 multidrug efflux protein NorA; Provisional; Region: PRK00187 1168865001717 cation binding site [ion binding]; other site 1168865001718 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168865001719 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168865001720 dimer interface [polypeptide binding]; other site 1168865001721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865001722 catalytic residue [active] 1168865001723 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1168865001724 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168865001725 catalytic residue [active] 1168865001726 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1168865001727 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1168865001728 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1168865001729 substrate binding pocket [chemical binding]; other site 1168865001730 active site 1168865001731 iron coordination sites [ion binding]; other site 1168865001732 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1168865001733 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168865001734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865001735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001736 dimer interface [polypeptide binding]; other site 1168865001737 conserved gate region; other site 1168865001738 putative PBP binding loops; other site 1168865001739 ABC-ATPase subunit interface; other site 1168865001740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1168865001741 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1168865001742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865001743 Walker A/P-loop; other site 1168865001744 ATP binding site [chemical binding]; other site 1168865001745 Q-loop/lid; other site 1168865001746 ABC transporter signature motif; other site 1168865001747 Walker B; other site 1168865001748 D-loop; other site 1168865001749 H-loop/switch region; other site 1168865001750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865001751 Walker A/P-loop; other site 1168865001752 ATP binding site [chemical binding]; other site 1168865001753 Q-loop/lid; other site 1168865001754 ABC transporter signature motif; other site 1168865001755 Walker B; other site 1168865001756 D-loop; other site 1168865001757 H-loop/switch region; other site 1168865001758 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1168865001759 active site 1168865001760 SAM binding site [chemical binding]; other site 1168865001761 homodimer interface [polypeptide binding]; other site 1168865001762 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1168865001763 catalytic residues [active] 1168865001764 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1168865001765 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1168865001766 folate binding site [chemical binding]; other site 1168865001767 NADP+ binding site [chemical binding]; other site 1168865001768 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1168865001769 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1168865001770 dimerization interface [polypeptide binding]; other site 1168865001771 active site 1168865001772 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1168865001773 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168865001774 active site 1168865001775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865001776 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1168865001777 ATP binding site [chemical binding]; other site 1168865001778 putative Mg++ binding site [ion binding]; other site 1168865001779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865001780 nucleotide binding region [chemical binding]; other site 1168865001781 ATP-binding site [chemical binding]; other site 1168865001782 DEAD/H associated; Region: DEAD_assoc; pfam08494 1168865001783 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1168865001784 active site 1168865001785 SUMO-1 interface [polypeptide binding]; other site 1168865001786 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1168865001787 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1168865001788 putative DNA binding site [nucleotide binding]; other site 1168865001789 catalytic residue [active] 1168865001790 putative H2TH interface [polypeptide binding]; other site 1168865001791 putative catalytic residues [active] 1168865001792 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168865001793 hypothetical protein; Provisional; Region: PRK11770 1168865001794 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1168865001795 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1168865001796 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1168865001797 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1168865001798 active site 1168865001799 dimer interface [polypeptide binding]; other site 1168865001800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1168865001801 dimer interface [polypeptide binding]; other site 1168865001802 active site 1168865001803 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168865001804 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1168865001805 tetramerization interface [polypeptide binding]; other site 1168865001806 NAD(P) binding site [chemical binding]; other site 1168865001807 catalytic residues [active] 1168865001808 hypothetical protein; Provisional; Region: PRK07857 1168865001809 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1168865001810 Peptidase family M23; Region: Peptidase_M23; pfam01551 1168865001811 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1168865001812 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1168865001813 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1168865001814 purine monophosphate binding site [chemical binding]; other site 1168865001815 dimer interface [polypeptide binding]; other site 1168865001816 putative catalytic residues [active] 1168865001817 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1168865001818 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168865001819 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1168865001820 Walker A/P-loop; other site 1168865001821 ATP binding site [chemical binding]; other site 1168865001822 Q-loop/lid; other site 1168865001823 ABC transporter signature motif; other site 1168865001824 Walker B; other site 1168865001825 D-loop; other site 1168865001826 H-loop/switch region; other site 1168865001827 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1168865001828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168865001829 substrate binding pocket [chemical binding]; other site 1168865001830 membrane-bound complex binding site; other site 1168865001831 hinge residues; other site 1168865001832 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168865001833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001834 dimer interface [polypeptide binding]; other site 1168865001835 conserved gate region; other site 1168865001836 putative PBP binding loops; other site 1168865001837 ABC-ATPase subunit interface; other site 1168865001838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865001839 dimer interface [polypeptide binding]; other site 1168865001840 conserved gate region; other site 1168865001841 putative PBP binding loops; other site 1168865001842 ABC-ATPase subunit interface; other site 1168865001843 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168865001844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865001845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865001846 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1168865001847 30S ribosomal protein S18; Provisional; Region: PRK13401 1168865001848 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1168865001849 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1168865001850 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1168865001851 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1168865001852 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1168865001853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168865001854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865001855 active site 1168865001856 phosphorylation site [posttranslational modification] 1168865001857 intermolecular recognition site; other site 1168865001858 dimerization interface [polypeptide binding]; other site 1168865001859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168865001860 DNA binding site [nucleotide binding] 1168865001861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168865001862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168865001863 dimerization interface [polypeptide binding]; other site 1168865001864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168865001865 dimer interface [polypeptide binding]; other site 1168865001866 phosphorylation site [posttranslational modification] 1168865001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865001868 ATP binding site [chemical binding]; other site 1168865001869 Mg2+ binding site [ion binding]; other site 1168865001870 G-X-G motif; other site 1168865001871 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1168865001872 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168865001873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1168865001874 protein binding site [polypeptide binding]; other site 1168865001875 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1168865001876 MPT binding site; other site 1168865001877 trimer interface [polypeptide binding]; other site 1168865001878 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1168865001879 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1168865001880 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1168865001881 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1168865001882 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1168865001883 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1168865001884 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1168865001885 active site 1168865001886 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1168865001887 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1168865001888 dimer interface [polypeptide binding]; other site 1168865001889 putative functional site; other site 1168865001890 putative MPT binding site; other site 1168865001891 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1168865001892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168865001893 Predicted membrane protein [Function unknown]; Region: COG2259 1168865001894 Predicted integral membrane protein [Function unknown]; Region: COG5660 1168865001895 Putative zinc-finger; Region: zf-HC2; pfam13490 1168865001896 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1168865001897 BCCT family transporter; Region: BCCT; pfam02028 1168865001898 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1168865001899 Predicted methyltransferases [General function prediction only]; Region: COG0313 1168865001900 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1168865001901 putative SAM binding site [chemical binding]; other site 1168865001902 putative homodimer interface [polypeptide binding]; other site 1168865001903 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1168865001904 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1168865001905 active site 1168865001906 HIGH motif; other site 1168865001907 KMSKS motif; other site 1168865001908 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1168865001909 tRNA binding surface [nucleotide binding]; other site 1168865001910 anticodon binding site; other site 1168865001911 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1168865001912 active site 1168865001913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1168865001914 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1168865001915 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1168865001916 G5 domain; Region: G5; pfam07501 1168865001917 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168865001918 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1168865001919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865001920 S-adenosylmethionine binding site [chemical binding]; other site 1168865001921 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1168865001922 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1168865001923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865001924 ABC transporter; Region: ABC_tran_2; pfam12848 1168865001925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865001926 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1168865001927 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1168865001928 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1168865001929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865001930 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1168865001931 active site 1168865001932 motif I; other site 1168865001933 motif II; other site 1168865001934 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1168865001935 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1168865001936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168865001937 substrate binding site [chemical binding]; other site 1168865001938 oxyanion hole (OAH) forming residues; other site 1168865001939 trimer interface [polypeptide binding]; other site 1168865001940 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1168865001941 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1168865001942 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1168865001943 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1168865001944 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1168865001945 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168865001946 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1168865001947 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1168865001948 G1 box; other site 1168865001949 putative GEF interaction site [polypeptide binding]; other site 1168865001950 GTP/Mg2+ binding site [chemical binding]; other site 1168865001951 Switch I region; other site 1168865001952 G2 box; other site 1168865001953 G3 box; other site 1168865001954 Switch II region; other site 1168865001955 G4 box; other site 1168865001956 G5 box; other site 1168865001957 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1168865001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865001959 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1168865001960 NAD(P) binding site [chemical binding]; other site 1168865001961 active site 1168865001962 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1168865001963 putative active site [active] 1168865001964 catalytic residue [active] 1168865001965 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1168865001966 putative active site [active] 1168865001967 catalytic residue [active] 1168865001968 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1168865001969 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1168865001970 5S rRNA interface [nucleotide binding]; other site 1168865001971 CTC domain interface [polypeptide binding]; other site 1168865001972 L16 interface [polypeptide binding]; other site 1168865001973 pullulanase, type I; Region: pulA_typeI; TIGR02104 1168865001974 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1168865001975 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1168865001976 Ca binding site [ion binding]; other site 1168865001977 active site 1168865001978 catalytic site [active] 1168865001979 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1168865001980 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1168865001981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865001982 active site 1168865001983 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1168865001984 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1168865001985 Substrate binding site; other site 1168865001986 Mg++ binding site; other site 1168865001987 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1168865001988 active site 1168865001989 substrate binding site [chemical binding]; other site 1168865001990 CoA binding site [chemical binding]; other site 1168865001991 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1168865001992 gating phenylalanine in ion channel; other site 1168865001993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865001994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865001995 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1168865001996 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1168865001997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865001998 ATP binding site [chemical binding]; other site 1168865001999 putative Mg++ binding site [ion binding]; other site 1168865002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002001 nucleotide binding region [chemical binding]; other site 1168865002002 ATP-binding site [chemical binding]; other site 1168865002003 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1168865002004 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1168865002005 Spore germination protein; Region: Spore_permease; cl17796 1168865002006 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1168865002007 homodimer interface [polypeptide binding]; other site 1168865002008 metal binding site [ion binding]; metal-binding site 1168865002009 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168865002010 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168865002011 enolase; Provisional; Region: eno; PRK00077 1168865002012 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1168865002013 dimer interface [polypeptide binding]; other site 1168865002014 metal binding site [ion binding]; metal-binding site 1168865002015 substrate binding pocket [chemical binding]; other site 1168865002016 Septum formation initiator; Region: DivIC; pfam04977 1168865002017 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1168865002018 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1168865002019 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1168865002020 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1168865002021 Helix-turn-helix domain; Region: HTH_18; pfam12833 1168865002022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168865002023 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1168865002024 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1168865002025 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1168865002026 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1168865002027 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1168865002028 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1168865002029 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1168865002030 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1168865002031 catalytic residue [active] 1168865002032 putative FPP diphosphate binding site; other site 1168865002033 putative FPP binding hydrophobic cleft; other site 1168865002034 dimer interface [polypeptide binding]; other site 1168865002035 putative IPP diphosphate binding site; other site 1168865002036 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1168865002037 pantothenate kinase; Provisional; Region: PRK05439 1168865002038 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1168865002039 ATP-binding site [chemical binding]; other site 1168865002040 CoA-binding site [chemical binding]; other site 1168865002041 Mg2+-binding site [ion binding]; other site 1168865002042 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1168865002043 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1168865002044 dimer interface [polypeptide binding]; other site 1168865002045 active site 1168865002046 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1168865002047 folate binding site [chemical binding]; other site 1168865002048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168865002049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865002050 putative substrate translocation pore; other site 1168865002051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865002052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865002053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168865002054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1168865002055 dimerization interface [polypeptide binding]; other site 1168865002056 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1168865002057 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1168865002058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865002059 Coenzyme A binding pocket [chemical binding]; other site 1168865002060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865002061 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1168865002062 putative substrate translocation pore; other site 1168865002063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865002064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865002065 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1168865002066 Class II fumarases; Region: Fumarase_classII; cd01362 1168865002067 active site 1168865002068 tetramer interface [polypeptide binding]; other site 1168865002069 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1168865002070 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1168865002071 putative active site [active] 1168865002072 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1168865002073 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1168865002074 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1168865002075 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1168865002076 generic binding surface II; other site 1168865002077 generic binding surface I; other site 1168865002078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1168865002079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1168865002080 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1168865002081 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1168865002082 GTP-binding protein YchF; Reviewed; Region: PRK09601 1168865002083 YchF GTPase; Region: YchF; cd01900 1168865002084 G1 box; other site 1168865002085 GTP/Mg2+ binding site [chemical binding]; other site 1168865002086 Switch I region; other site 1168865002087 G2 box; other site 1168865002088 Switch II region; other site 1168865002089 G3 box; other site 1168865002090 G4 box; other site 1168865002091 G5 box; other site 1168865002092 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1168865002093 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1168865002094 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1168865002095 PhnA protein; Region: PhnA; pfam03831 1168865002096 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168865002097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168865002098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002099 Walker A/P-loop; other site 1168865002100 ATP binding site [chemical binding]; other site 1168865002101 Q-loop/lid; other site 1168865002102 ABC transporter signature motif; other site 1168865002103 Walker B; other site 1168865002104 D-loop; other site 1168865002105 H-loop/switch region; other site 1168865002106 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1168865002107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168865002108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002109 Walker A/P-loop; other site 1168865002110 ATP binding site [chemical binding]; other site 1168865002111 Q-loop/lid; other site 1168865002112 ABC transporter signature motif; other site 1168865002113 Walker B; other site 1168865002114 D-loop; other site 1168865002115 H-loop/switch region; other site 1168865002116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002117 Walker A/P-loop; other site 1168865002118 ATP binding site [chemical binding]; other site 1168865002119 Q-loop/lid; other site 1168865002120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168865002121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002122 Walker A/P-loop; other site 1168865002123 ATP binding site [chemical binding]; other site 1168865002124 Q-loop/lid; other site 1168865002125 ABC transporter; Region: ABC_tran; pfam00005 1168865002126 ABC transporter signature motif; other site 1168865002127 Walker B; other site 1168865002128 D-loop; other site 1168865002129 H-loop/switch region; other site 1168865002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1168865002131 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1168865002132 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1168865002133 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1168865002134 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1168865002135 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168865002136 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168865002137 Walker A/P-loop; other site 1168865002138 ATP binding site [chemical binding]; other site 1168865002139 Q-loop/lid; other site 1168865002140 ABC transporter signature motif; other site 1168865002141 Walker B; other site 1168865002142 D-loop; other site 1168865002143 H-loop/switch region; other site 1168865002144 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168865002145 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1168865002146 Walker A/P-loop; other site 1168865002147 ATP binding site [chemical binding]; other site 1168865002148 Q-loop/lid; other site 1168865002149 ABC transporter signature motif; other site 1168865002150 Walker B; other site 1168865002151 D-loop; other site 1168865002152 H-loop/switch region; other site 1168865002153 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168865002154 hypothetical protein; Provisional; Region: PRK06547 1168865002155 AAA domain; Region: AAA_18; pfam13238 1168865002156 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1168865002157 nudix motif; other site 1168865002158 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1168865002159 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1168865002160 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865002161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865002162 dimer interface [polypeptide binding]; other site 1168865002163 conserved gate region; other site 1168865002164 ABC-ATPase subunit interface; other site 1168865002165 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168865002166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865002167 dimer interface [polypeptide binding]; other site 1168865002168 conserved gate region; other site 1168865002169 putative PBP binding loops; other site 1168865002170 ABC-ATPase subunit interface; other site 1168865002171 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168865002172 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865002173 Walker A/P-loop; other site 1168865002174 ATP binding site [chemical binding]; other site 1168865002175 Q-loop/lid; other site 1168865002176 ABC transporter signature motif; other site 1168865002177 Walker B; other site 1168865002178 D-loop; other site 1168865002179 H-loop/switch region; other site 1168865002180 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865002181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865002182 Walker A/P-loop; other site 1168865002183 ATP binding site [chemical binding]; other site 1168865002184 Q-loop/lid; other site 1168865002185 ABC transporter signature motif; other site 1168865002186 Walker B; other site 1168865002187 D-loop; other site 1168865002188 H-loop/switch region; other site 1168865002189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865002190 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1168865002191 cleavage site 1168865002192 active site 1168865002193 substrate binding sites [chemical binding]; other site 1168865002194 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1168865002195 ArsC family; Region: ArsC; pfam03960 1168865002196 catalytic residues [active] 1168865002197 Protein of unknown function (DUF402); Region: DUF402; cl00979 1168865002198 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1168865002199 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1168865002200 G1 box; other site 1168865002201 GTP/Mg2+ binding site [chemical binding]; other site 1168865002202 G2 box; other site 1168865002203 Switch I region; other site 1168865002204 G3 box; other site 1168865002205 Switch II region; other site 1168865002206 G4 box; other site 1168865002207 G5 box; other site 1168865002208 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1168865002209 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1168865002210 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1168865002211 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168865002212 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1168865002213 Ferredoxin [Energy production and conversion]; Region: COG1146 1168865002214 4Fe-4S binding domain; Region: Fer4; pfam00037 1168865002215 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1168865002216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865002217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865002218 homodimer interface [polypeptide binding]; other site 1168865002219 catalytic residue [active] 1168865002220 Predicted membrane protein [Function unknown]; Region: COG2246 1168865002221 GtrA-like protein; Region: GtrA; pfam04138 1168865002222 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168865002223 active site 1168865002224 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168865002225 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1168865002226 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1168865002227 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1168865002228 putative trimer interface [polypeptide binding]; other site 1168865002229 putative CoA binding site [chemical binding]; other site 1168865002230 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168865002231 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1168865002232 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1168865002233 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168865002234 putative trimer interface [polypeptide binding]; other site 1168865002235 putative CoA binding site [chemical binding]; other site 1168865002236 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1168865002237 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1168865002238 metal binding site [ion binding]; metal-binding site 1168865002239 putative dimer interface [polypeptide binding]; other site 1168865002240 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1168865002241 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1168865002242 dihydropteroate synthase; Region: DHPS; TIGR01496 1168865002243 substrate binding pocket [chemical binding]; other site 1168865002244 dimer interface [polypeptide binding]; other site 1168865002245 inhibitor binding site; inhibition site 1168865002246 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1168865002247 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1168865002248 Ligand binding site; other site 1168865002249 Putative Catalytic site; other site 1168865002250 DXD motif; other site 1168865002251 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168865002252 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1168865002253 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1168865002254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002255 S-adenosylmethionine binding site [chemical binding]; other site 1168865002256 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1168865002257 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1168865002258 active site 1168865002259 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1168865002260 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1168865002261 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1168865002262 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168865002263 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1168865002264 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1168865002265 ligand binding site; other site 1168865002266 oligomer interface; other site 1168865002267 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1168865002268 dimer interface [polypeptide binding]; other site 1168865002269 N-terminal domain interface [polypeptide binding]; other site 1168865002270 sulfate 1 binding site; other site 1168865002271 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1168865002272 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1168865002273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865002274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865002275 DNA binding residues [nucleotide binding] 1168865002276 sec-independent translocase; Provisional; Region: tatB; PRK00182 1168865002277 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1168865002278 Domain of unknown function DUF59; Region: DUF59; pfam01883 1168865002279 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1168865002280 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1168865002281 Predicted membrane protein [Function unknown]; Region: COG4420 1168865002282 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1168865002283 MgtE intracellular N domain; Region: MgtE_N; smart00924 1168865002284 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1168865002285 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1168865002286 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1168865002287 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1168865002288 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1168865002289 TPP-binding site [chemical binding]; other site 1168865002290 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1168865002291 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168865002292 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168865002293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002294 Walker A/P-loop; other site 1168865002295 ATP binding site [chemical binding]; other site 1168865002296 Q-loop/lid; other site 1168865002297 ABC transporter signature motif; other site 1168865002298 Walker B; other site 1168865002299 D-loop; other site 1168865002300 H-loop/switch region; other site 1168865002301 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168865002302 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168865002303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002304 Walker A/P-loop; other site 1168865002305 ATP binding site [chemical binding]; other site 1168865002306 Q-loop/lid; other site 1168865002307 ABC transporter signature motif; other site 1168865002308 Walker B; other site 1168865002309 D-loop; other site 1168865002310 H-loop/switch region; other site 1168865002311 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1168865002312 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1168865002313 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1168865002314 shikimate binding site; other site 1168865002315 NAD(P) binding site [chemical binding]; other site 1168865002316 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1168865002317 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168865002318 substrate binding pocket [chemical binding]; other site 1168865002319 catalytic triad [active] 1168865002320 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1168865002321 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1168865002322 active site 1168865002323 catalytic residues [active] 1168865002324 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1168865002325 putative transporter; Provisional; Region: PRK10484 1168865002326 Na binding site [ion binding]; other site 1168865002327 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1168865002328 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1168865002329 nucleotide binding site/active site [active] 1168865002330 HIT family signature motif; other site 1168865002331 catalytic residue [active] 1168865002332 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1168865002333 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1168865002334 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1168865002335 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1168865002336 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1168865002337 ATP binding site [chemical binding]; other site 1168865002338 Mg++ binding site [ion binding]; other site 1168865002339 motif III; other site 1168865002340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002341 nucleotide binding region [chemical binding]; other site 1168865002342 ATP-binding site [chemical binding]; other site 1168865002343 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1168865002344 putative RNA binding site [nucleotide binding]; other site 1168865002345 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1168865002346 dimer interface [polypeptide binding]; other site 1168865002347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168865002348 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1168865002349 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1168865002350 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1168865002351 Na binding site [ion binding]; other site 1168865002352 SNF2 Helicase protein; Region: DUF3670; pfam12419 1168865002353 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1168865002354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865002355 ATP binding site [chemical binding]; other site 1168865002356 putative Mg++ binding site [ion binding]; other site 1168865002357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002358 nucleotide binding region [chemical binding]; other site 1168865002359 ATP-binding site [chemical binding]; other site 1168865002360 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1168865002361 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1168865002362 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1168865002363 active site 1168865002364 metal binding site [ion binding]; metal-binding site 1168865002365 DNA binding site [nucleotide binding] 1168865002366 AAA domain; Region: AAA_23; pfam13476 1168865002367 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1168865002368 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1168865002369 MarR family; Region: MarR_2; pfam12802 1168865002370 PspC domain; Region: PspC; pfam04024 1168865002371 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1168865002372 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1168865002373 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1168865002374 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1168865002375 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1168865002376 Cysteine-rich domain; Region: CCG; pfam02754 1168865002377 Cysteine-rich domain; Region: CCG; pfam02754 1168865002378 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1168865002379 L-lactate permease; Region: Lactate_perm; cl00701 1168865002380 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1168865002381 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1168865002382 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1168865002383 active site 1168865002384 HIGH motif; other site 1168865002385 KMSK motif region; other site 1168865002386 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1168865002387 tRNA binding surface [nucleotide binding]; other site 1168865002388 anticodon binding site; other site 1168865002389 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1168865002390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1168865002391 active site 1168865002392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168865002393 substrate binding site [chemical binding]; other site 1168865002394 catalytic residues [active] 1168865002395 dimer interface [polypeptide binding]; other site 1168865002396 homoserine dehydrogenase; Provisional; Region: PRK06349 1168865002397 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1168865002398 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1168865002399 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1168865002400 homoserine kinase; Provisional; Region: PRK01212 1168865002401 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168865002402 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 1168865002403 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1168865002404 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865002405 acyl-activating enzyme (AAE) consensus motif; other site 1168865002406 AMP binding site [chemical binding]; other site 1168865002407 active site 1168865002408 CoA binding site [chemical binding]; other site 1168865002409 transcription termination factor Rho; Provisional; Region: PRK12678 1168865002410 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1168865002411 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1168865002412 RNA binding site [nucleotide binding]; other site 1168865002413 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1168865002414 multimer interface [polypeptide binding]; other site 1168865002415 Walker A motif; other site 1168865002416 ATP binding site [chemical binding]; other site 1168865002417 Walker B motif; other site 1168865002418 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1168865002419 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1168865002420 RF-1 domain; Region: RF-1; pfam00472 1168865002421 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1168865002422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002423 S-adenosylmethionine binding site [chemical binding]; other site 1168865002424 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1168865002425 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1168865002426 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1168865002427 Mg++ binding site [ion binding]; other site 1168865002428 putative catalytic motif [active] 1168865002429 substrate binding site [chemical binding]; other site 1168865002430 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1168865002431 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1168865002432 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1168865002433 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1168865002434 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1168865002435 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1168865002436 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1168865002437 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1168865002438 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1168865002439 beta subunit interaction interface [polypeptide binding]; other site 1168865002440 Walker A motif; other site 1168865002441 ATP binding site [chemical binding]; other site 1168865002442 Walker B motif; other site 1168865002443 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1168865002444 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1168865002445 core domain interface [polypeptide binding]; other site 1168865002446 delta subunit interface [polypeptide binding]; other site 1168865002447 epsilon subunit interface [polypeptide binding]; other site 1168865002448 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1168865002449 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1168865002450 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1168865002451 alpha subunit interaction interface [polypeptide binding]; other site 1168865002452 Walker A motif; other site 1168865002453 ATP binding site [chemical binding]; other site 1168865002454 Walker B motif; other site 1168865002455 inhibitor binding site; inhibition site 1168865002456 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1168865002457 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1168865002458 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1168865002459 gamma subunit interface [polypeptide binding]; other site 1168865002460 epsilon subunit interface [polypeptide binding]; other site 1168865002461 LBP interface [polypeptide binding]; other site 1168865002462 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1168865002463 hypothetical protein; Provisional; Region: PRK03298 1168865002464 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1168865002465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168865002466 dimer interface [polypeptide binding]; other site 1168865002467 substrate binding site [chemical binding]; other site 1168865002468 metal binding site [ion binding]; metal-binding site 1168865002469 Domain of unknown function DUF77; Region: DUF77; pfam01910 1168865002470 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1168865002471 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1168865002472 glycogen branching enzyme; Provisional; Region: PRK05402 1168865002473 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1168865002474 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1168865002475 active site 1168865002476 catalytic site [active] 1168865002477 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1168865002478 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1168865002479 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168865002480 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168865002481 active site 1168865002482 catalytic site [active] 1168865002483 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168865002484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865002485 Walker A/P-loop; other site 1168865002486 ATP binding site [chemical binding]; other site 1168865002487 ABC transporter signature motif; other site 1168865002488 Walker B; other site 1168865002489 D-loop; other site 1168865002490 H-loop/switch region; other site 1168865002491 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1168865002492 Ligand binding site [chemical binding]; other site 1168865002493 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1168865002494 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1168865002495 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1168865002496 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1168865002497 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1168865002498 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1168865002499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168865002500 catalytic residue [active] 1168865002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002502 S-adenosylmethionine binding site [chemical binding]; other site 1168865002503 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1168865002504 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1168865002505 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1168865002506 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1168865002507 active site 1168865002508 catalytic site [active] 1168865002509 substrate binding site [chemical binding]; other site 1168865002510 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1168865002511 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1168865002512 nucleotide binding pocket [chemical binding]; other site 1168865002513 K-X-D-G motif; other site 1168865002514 catalytic site [active] 1168865002515 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1168865002516 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1168865002517 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1168865002518 Dimer interface [polypeptide binding]; other site 1168865002519 BRCT sequence motif; other site 1168865002520 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1168865002521 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1168865002522 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1168865002523 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1168865002524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168865002525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865002526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168865002527 putative substrate translocation pore; other site 1168865002528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865002529 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865002530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865002531 ABC-ATPase subunit interface; other site 1168865002532 dimer interface [polypeptide binding]; other site 1168865002533 putative PBP binding regions; other site 1168865002534 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865002535 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1168865002536 Walker A/P-loop; other site 1168865002537 ATP binding site [chemical binding]; other site 1168865002538 Q-loop/lid; other site 1168865002539 ABC transporter signature motif; other site 1168865002540 Walker B; other site 1168865002541 D-loop; other site 1168865002542 H-loop/switch region; other site 1168865002543 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1168865002544 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1168865002545 putative ligand binding residues [chemical binding]; other site 1168865002546 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1168865002547 phosphofructokinase; Region: PFK_mixed; TIGR02483 1168865002548 active site 1168865002549 ADP/pyrophosphate binding site [chemical binding]; other site 1168865002550 dimerization interface [polypeptide binding]; other site 1168865002551 allosteric effector site; other site 1168865002552 fructose-1,6-bisphosphate binding site; other site 1168865002553 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1168865002554 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1168865002555 GatB domain; Region: GatB_Yqey; smart00845 1168865002556 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168865002557 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168865002558 active site 1168865002559 catalytic tetrad [active] 1168865002560 Lysine efflux permease [General function prediction only]; Region: COG1279 1168865002561 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1168865002562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168865002563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1168865002564 dimerization interface [polypeptide binding]; other site 1168865002565 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1168865002566 Predicted membrane protein [Function unknown]; Region: COG2259 1168865002567 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1168865002568 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1168865002569 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1168865002570 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1168865002571 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1168865002572 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168865002573 PYR/PP interface [polypeptide binding]; other site 1168865002574 dimer interface [polypeptide binding]; other site 1168865002575 TPP binding site [chemical binding]; other site 1168865002576 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168865002577 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1168865002578 TPP-binding site [chemical binding]; other site 1168865002579 dimer interface [polypeptide binding]; other site 1168865002580 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1168865002581 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1168865002582 putative valine binding site [chemical binding]; other site 1168865002583 dimer interface [polypeptide binding]; other site 1168865002584 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1168865002585 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1168865002586 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1168865002587 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1168865002588 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1168865002589 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1168865002590 Protein of unknown function DUF262; Region: DUF262; pfam03235 1168865002591 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1168865002592 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1168865002593 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1168865002594 ligand binding site [chemical binding]; other site 1168865002595 NAD binding site [chemical binding]; other site 1168865002596 dimerization interface [polypeptide binding]; other site 1168865002597 catalytic site [active] 1168865002598 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1168865002599 putative L-serine binding site [chemical binding]; other site 1168865002600 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1168865002601 tartrate dehydrogenase; Region: TTC; TIGR02089 1168865002602 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1168865002603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168865002604 ligand binding site [chemical binding]; other site 1168865002605 flexible hinge region; other site 1168865002606 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1168865002607 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168865002608 metal binding triad; other site 1168865002609 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1168865002610 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1168865002611 active site 1168865002612 catalytic site [active] 1168865002613 substrate binding site [chemical binding]; other site 1168865002614 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1168865002615 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1168865002616 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1168865002617 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168865002618 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1168865002619 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1168865002620 active site 1168865002621 HIGH motif; other site 1168865002622 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1168865002623 active site 1168865002624 KMSKS motif; other site 1168865002625 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1168865002626 Cutinase; Region: Cutinase; pfam01083 1168865002627 biotin synthase; Region: bioB; TIGR00433 1168865002628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865002629 FeS/SAM binding site; other site 1168865002630 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1168865002631 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1168865002632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168865002633 Zn2+ binding site [ion binding]; other site 1168865002634 Mg2+ binding site [ion binding]; other site 1168865002635 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168865002636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168865002637 putative DNA binding site [nucleotide binding]; other site 1168865002638 putative Zn2+ binding site [ion binding]; other site 1168865002639 Bacterial transcriptional regulator; Region: IclR; pfam01614 1168865002640 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1168865002641 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1168865002642 substrate binding site [chemical binding]; other site 1168865002643 ligand binding site [chemical binding]; other site 1168865002644 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1168865002645 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1168865002646 substrate binding site [chemical binding]; other site 1168865002647 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1168865002648 active site 1168865002649 Ap6A binding site [chemical binding]; other site 1168865002650 nudix motif; other site 1168865002651 metal binding site [ion binding]; metal-binding site 1168865002652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865002653 catalytic core [active] 1168865002654 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1168865002655 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1168865002656 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1168865002657 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1168865002658 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1168865002659 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168865002660 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1168865002661 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1168865002662 thiamine monophosphate kinase; Provisional; Region: PRK05731 1168865002663 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1168865002664 ATP binding site [chemical binding]; other site 1168865002665 dimerization interface [polypeptide binding]; other site 1168865002666 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1168865002667 DAK2 domain; Region: Dak2; pfam02734 1168865002668 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1168865002669 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1168865002670 generic binding surface II; other site 1168865002671 ssDNA binding site; other site 1168865002672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865002673 ATP binding site [chemical binding]; other site 1168865002674 putative Mg++ binding site [ion binding]; other site 1168865002675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002676 nucleotide binding region [chemical binding]; other site 1168865002677 ATP-binding site [chemical binding]; other site 1168865002678 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1168865002679 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168865002680 carboxyltransferase (CT) interaction site; other site 1168865002681 biotinylation site [posttranslational modification]; other site 1168865002682 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1168865002683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002684 S-adenosylmethionine binding site [chemical binding]; other site 1168865002685 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1168865002686 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1168865002687 active site 1168865002688 (T/H)XGH motif; other site 1168865002689 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1168865002690 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1168865002691 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168865002692 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1168865002693 Walker A/P-loop; other site 1168865002694 ATP binding site [chemical binding]; other site 1168865002695 Q-loop/lid; other site 1168865002696 ABC transporter signature motif; other site 1168865002697 Walker B; other site 1168865002698 D-loop; other site 1168865002699 H-loop/switch region; other site 1168865002700 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168865002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865002702 dimer interface [polypeptide binding]; other site 1168865002703 conserved gate region; other site 1168865002704 putative PBP binding loops; other site 1168865002705 ABC-ATPase subunit interface; other site 1168865002706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168865002707 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168865002708 substrate binding pocket [chemical binding]; other site 1168865002709 membrane-bound complex binding site; other site 1168865002710 hinge residues; other site 1168865002711 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1168865002712 DNA polymerase I; Provisional; Region: PRK05755 1168865002713 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1168865002714 active site 1168865002715 metal binding site 1 [ion binding]; metal-binding site 1168865002716 putative 5' ssDNA interaction site; other site 1168865002717 metal binding site 3; metal-binding site 1168865002718 metal binding site 2 [ion binding]; metal-binding site 1168865002719 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1168865002720 putative DNA binding site [nucleotide binding]; other site 1168865002721 putative metal binding site [ion binding]; other site 1168865002722 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1168865002723 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1168865002724 active site 1168865002725 DNA binding site [nucleotide binding] 1168865002726 catalytic site [active] 1168865002727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002728 S-adenosylmethionine binding site [chemical binding]; other site 1168865002729 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1168865002730 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1168865002731 RNA binding site [nucleotide binding]; other site 1168865002732 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1168865002733 RNA binding site [nucleotide binding]; other site 1168865002734 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1168865002735 RNA binding site [nucleotide binding]; other site 1168865002736 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1168865002737 RNA binding site [nucleotide binding]; other site 1168865002738 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1168865002739 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1168865002740 active site turn [active] 1168865002741 phosphorylation site [posttranslational modification] 1168865002742 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1168865002743 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1168865002744 HPr interaction site; other site 1168865002745 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1168865002746 active site 1168865002747 phosphorylation site [posttranslational modification] 1168865002748 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1168865002749 ATP-binding [chemical binding]; other site 1168865002750 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1168865002751 CoA-binding site [chemical binding]; other site 1168865002752 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1168865002753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865002754 FeS/SAM binding site; other site 1168865002755 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1168865002756 excinuclease ABC subunit B; Provisional; Region: PRK05298 1168865002757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865002758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002759 nucleotide binding region [chemical binding]; other site 1168865002760 ATP-binding site [chemical binding]; other site 1168865002761 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1168865002762 UvrB/uvrC motif; Region: UVR; pfam02151 1168865002763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168865002764 Ligand Binding Site [chemical binding]; other site 1168865002765 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1168865002766 Part of AAA domain; Region: AAA_19; pfam13245 1168865002767 Family description; Region: UvrD_C_2; pfam13538 1168865002768 Predicted membrane protein [Function unknown]; Region: COG2259 1168865002769 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168865002770 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1168865002771 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168865002772 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168865002773 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1168865002774 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1168865002775 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1168865002776 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1168865002777 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1168865002778 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1168865002779 23S rRNA binding site [nucleotide binding]; other site 1168865002780 L21 binding site [polypeptide binding]; other site 1168865002781 L13 binding site [polypeptide binding]; other site 1168865002782 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168865002783 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1168865002784 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168865002785 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1168865002786 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1168865002787 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1168865002788 dimer interface [polypeptide binding]; other site 1168865002789 motif 1; other site 1168865002790 active site 1168865002791 motif 2; other site 1168865002792 motif 3; other site 1168865002793 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1168865002794 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1168865002795 putative tRNA-binding site [nucleotide binding]; other site 1168865002796 B3/4 domain; Region: B3_4; pfam03483 1168865002797 tRNA synthetase B5 domain; Region: B5; smart00874 1168865002798 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1168865002799 dimer interface [polypeptide binding]; other site 1168865002800 motif 1; other site 1168865002801 motif 3; other site 1168865002802 motif 2; other site 1168865002803 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1168865002804 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1168865002805 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168865002806 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1168865002807 heterotetramer interface [polypeptide binding]; other site 1168865002808 active site pocket [active] 1168865002809 cleavage site 1168865002810 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1168865002811 feedback inhibition sensing region; other site 1168865002812 homohexameric interface [polypeptide binding]; other site 1168865002813 nucleotide binding site [chemical binding]; other site 1168865002814 N-acetyl-L-glutamate binding site [chemical binding]; other site 1168865002815 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1168865002816 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168865002817 inhibitor-cofactor binding pocket; inhibition site 1168865002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865002819 catalytic residue [active] 1168865002820 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1168865002821 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1168865002822 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1168865002823 arginine repressor; Provisional; Region: PRK03341 1168865002824 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1168865002825 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1168865002826 argininosuccinate synthase; Provisional; Region: PRK13820 1168865002827 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1168865002828 ANP binding site [chemical binding]; other site 1168865002829 Substrate Binding Site II [chemical binding]; other site 1168865002830 Substrate Binding Site I [chemical binding]; other site 1168865002831 argininosuccinate lyase; Provisional; Region: PRK00855 1168865002832 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1168865002833 active sites [active] 1168865002834 tetramer interface [polypeptide binding]; other site 1168865002835 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1168865002836 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1168865002837 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1168865002838 active site 1168865002839 HIGH motif; other site 1168865002840 dimer interface [polypeptide binding]; other site 1168865002841 KMSKS motif; other site 1168865002842 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865002843 RNA binding surface [nucleotide binding]; other site 1168865002844 transcription termination factor Rho; Provisional; Region: PRK12678 1168865002845 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1168865002846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865002847 active site 1168865002848 motif I; other site 1168865002849 motif II; other site 1168865002850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865002851 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1168865002852 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865002853 RNA binding surface [nucleotide binding]; other site 1168865002854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002855 S-adenosylmethionine binding site [chemical binding]; other site 1168865002856 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1168865002857 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1168865002858 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1168865002859 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1168865002860 Walker A/P-loop; other site 1168865002861 ATP binding site [chemical binding]; other site 1168865002862 Q-loop/lid; other site 1168865002863 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1168865002864 ABC transporter signature motif; other site 1168865002865 Walker B; other site 1168865002866 D-loop; other site 1168865002867 H-loop/switch region; other site 1168865002868 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1168865002869 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1168865002870 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1168865002871 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1168865002872 dimer interface [polypeptide binding]; other site 1168865002873 ADP-ribose binding site [chemical binding]; other site 1168865002874 active site 1168865002875 nudix motif; other site 1168865002876 metal binding site [ion binding]; metal-binding site 1168865002877 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1168865002878 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1168865002879 active site 1168865002880 Int/Topo IB signature motif; other site 1168865002881 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168865002882 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168865002883 P-loop; other site 1168865002884 Magnesium ion binding site [ion binding]; other site 1168865002885 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1168865002886 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1168865002887 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1168865002888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865002889 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1168865002890 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168865002891 inhibitor-cofactor binding pocket; inhibition site 1168865002892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865002893 catalytic residue [active] 1168865002894 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1168865002895 AAA domain; Region: AAA_26; pfam13500 1168865002896 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1168865002897 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1168865002898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865002899 RNA binding surface [nucleotide binding]; other site 1168865002900 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1168865002901 active site 1168865002902 cytidylate kinase; Provisional; Region: cmk; PRK00023 1168865002903 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1168865002904 CMP-binding site; other site 1168865002905 The sites determining sugar specificity; other site 1168865002906 GTP-binding protein Der; Reviewed; Region: PRK03003 1168865002907 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1168865002908 G1 box; other site 1168865002909 GTP/Mg2+ binding site [chemical binding]; other site 1168865002910 Switch I region; other site 1168865002911 G2 box; other site 1168865002912 Switch II region; other site 1168865002913 G3 box; other site 1168865002914 G4 box; other site 1168865002915 G5 box; other site 1168865002916 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1168865002917 G1 box; other site 1168865002918 GTP/Mg2+ binding site [chemical binding]; other site 1168865002919 Switch I region; other site 1168865002920 G2 box; other site 1168865002921 G3 box; other site 1168865002922 Switch II region; other site 1168865002923 G4 box; other site 1168865002924 G5 box; other site 1168865002925 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1168865002926 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1168865002927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865002928 S-adenosylmethionine binding site [chemical binding]; other site 1168865002929 Putative esterase; Region: Esterase; pfam00756 1168865002930 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1168865002931 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1168865002932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865002933 intersubunit interface [polypeptide binding]; other site 1168865002934 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865002935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865002936 dimer interface [polypeptide binding]; other site 1168865002937 ABC-ATPase subunit interface; other site 1168865002938 putative PBP binding regions; other site 1168865002939 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865002940 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865002941 ABC-ATPase subunit interface; other site 1168865002942 dimer interface [polypeptide binding]; other site 1168865002943 putative PBP binding regions; other site 1168865002944 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1168865002945 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865002946 Walker A/P-loop; other site 1168865002947 ATP binding site [chemical binding]; other site 1168865002948 Q-loop/lid; other site 1168865002949 ABC transporter signature motif; other site 1168865002950 Walker B; other site 1168865002951 D-loop; other site 1168865002952 H-loop/switch region; other site 1168865002953 IucA / IucC family; Region: IucA_IucC; pfam04183 1168865002954 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1168865002955 IucA / IucC family; Region: IucA_IucC; pfam04183 1168865002956 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1168865002957 H+ Antiporter protein; Region: 2A0121; TIGR00900 1168865002958 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168865002959 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168865002960 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1168865002961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168865002962 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1168865002963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002964 nucleotide binding region [chemical binding]; other site 1168865002965 ATP-binding site [chemical binding]; other site 1168865002966 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168865002967 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168865002968 phosphopeptide binding site; other site 1168865002969 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1168865002970 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168865002971 DNA binding residues [nucleotide binding] 1168865002972 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1168865002973 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1168865002974 DNA binding residues [nucleotide binding] 1168865002975 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168865002976 putative dimer interface [polypeptide binding]; other site 1168865002977 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168865002978 metal ion-dependent adhesion site (MIDAS); other site 1168865002979 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168865002980 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168865002981 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168865002982 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168865002983 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168865002984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168865002985 Transporter associated domain; Region: CorC_HlyC; smart01091 1168865002986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168865002987 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1168865002988 ATP binding site [chemical binding]; other site 1168865002989 putative Mg++ binding site [ion binding]; other site 1168865002990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865002991 nucleotide binding region [chemical binding]; other site 1168865002992 ATP-binding site [chemical binding]; other site 1168865002993 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168865002994 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1168865002995 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1168865002996 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168865002997 CoenzymeA binding site [chemical binding]; other site 1168865002998 subunit interaction site [polypeptide binding]; other site 1168865002999 PHB binding site; other site 1168865003000 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168865003001 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1168865003002 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1168865003003 oligomer interface [polypeptide binding]; other site 1168865003004 metal binding site [ion binding]; metal-binding site 1168865003005 metal binding site [ion binding]; metal-binding site 1168865003006 putative Cl binding site [ion binding]; other site 1168865003007 basic sphincter; other site 1168865003008 hydrophobic gate; other site 1168865003009 periplasmic entrance; other site 1168865003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865003011 S-adenosylmethionine binding site [chemical binding]; other site 1168865003012 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1168865003013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168865003014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168865003015 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1168865003016 metabolite-proton symporter; Region: 2A0106; TIGR00883 1168865003017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865003018 putative substrate translocation pore; other site 1168865003019 YceI-like domain; Region: YceI; pfam04264 1168865003020 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1168865003021 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1168865003022 Ligand binding site; other site 1168865003023 Putative Catalytic site; other site 1168865003024 DXD motif; other site 1168865003025 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1168865003026 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1168865003027 putative active site [active] 1168865003028 catalytic triad [active] 1168865003029 putative dimer interface [polypeptide binding]; other site 1168865003030 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1168865003031 precorrin-3B synthase; Region: CobG; TIGR02435 1168865003032 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168865003033 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168865003034 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1168865003035 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1168865003036 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1168865003037 active site 1168865003038 SAM binding site [chemical binding]; other site 1168865003039 homodimer interface [polypeptide binding]; other site 1168865003040 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1168865003041 active site 1168865003042 SAM binding site [chemical binding]; other site 1168865003043 homodimer interface [polypeptide binding]; other site 1168865003044 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1168865003045 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1168865003046 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1168865003047 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1168865003048 active site 1168865003049 SAM binding site [chemical binding]; other site 1168865003050 homodimer interface [polypeptide binding]; other site 1168865003051 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1168865003052 active site 1168865003053 putative homodimer interface [polypeptide binding]; other site 1168865003054 SAM binding site [chemical binding]; other site 1168865003055 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1168865003056 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1168865003057 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168865003058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865003059 NAD(P) binding site [chemical binding]; other site 1168865003060 active site 1168865003061 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168865003062 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168865003063 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1168865003064 active site 1168865003065 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1168865003066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865003067 ATP binding site [chemical binding]; other site 1168865003068 putative Mg++ binding site [ion binding]; other site 1168865003069 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1168865003070 nucleotide binding region [chemical binding]; other site 1168865003071 ATP-binding site [chemical binding]; other site 1168865003072 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1168865003073 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1168865003074 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1168865003075 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1168865003076 Predicted transcriptional regulator [Transcription]; Region: COG2378 1168865003077 WYL domain; Region: WYL; pfam13280 1168865003078 Predicted transcriptional regulator [Transcription]; Region: COG2378 1168865003079 WYL domain; Region: WYL; pfam13280 1168865003080 Pup-ligase protein; Region: Pup_ligase; cl15463 1168865003081 Pup-like protein; Region: Pup; pfam05639 1168865003082 Pup-ligase protein; Region: Pup_ligase; cl15463 1168865003083 proteasome ATPase; Region: pup_AAA; TIGR03689 1168865003084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865003085 Walker A motif; other site 1168865003086 ATP binding site [chemical binding]; other site 1168865003087 Walker B motif; other site 1168865003088 arginine finger; other site 1168865003089 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1168865003090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168865003091 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1168865003092 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1168865003093 active site 1168865003094 metal binding site [ion binding]; metal-binding site 1168865003095 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1168865003096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1168865003097 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1168865003098 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1168865003099 Potassium binding sites [ion binding]; other site 1168865003100 Cesium cation binding sites [ion binding]; other site 1168865003101 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1168865003102 Aspartase; Region: Aspartase; cd01357 1168865003103 active sites [active] 1168865003104 tetramer interface [polypeptide binding]; other site 1168865003105 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1168865003106 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1168865003107 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1168865003108 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1168865003109 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1168865003110 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1168865003111 homodimer interface [polypeptide binding]; other site 1168865003112 putative metal binding site [ion binding]; other site 1168865003113 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1168865003114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865003115 motif II; other site 1168865003116 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1168865003117 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1168865003118 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1168865003119 substrate binding pocket [chemical binding]; other site 1168865003120 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1168865003121 B12 binding site [chemical binding]; other site 1168865003122 cobalt ligand [ion binding]; other site 1168865003123 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1168865003124 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1168865003125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168865003126 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168865003127 active site 1168865003128 catalytic tetrad [active] 1168865003129 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1168865003130 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1168865003131 quinone interaction residues [chemical binding]; other site 1168865003132 active site 1168865003133 catalytic residues [active] 1168865003134 FMN binding site [chemical binding]; other site 1168865003135 substrate binding site [chemical binding]; other site 1168865003136 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1168865003137 substrate binding site [chemical binding]; other site 1168865003138 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1168865003139 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1168865003140 dimerization domain swap beta strand [polypeptide binding]; other site 1168865003141 regulatory protein interface [polypeptide binding]; other site 1168865003142 active site 1168865003143 regulatory phosphorylation site [posttranslational modification]; other site 1168865003144 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1168865003145 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1168865003146 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1168865003147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865003148 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1168865003149 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865003150 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1168865003151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865003152 NAD(P) binding site [chemical binding]; other site 1168865003153 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168865003154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865003155 NAD(P) binding site [chemical binding]; other site 1168865003156 active site 1168865003157 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1168865003158 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1168865003159 Walker A; other site 1168865003160 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1168865003161 G4 box; other site 1168865003162 G5 box; other site 1168865003163 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1168865003164 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1168865003165 active site 1168865003166 substrate binding site [chemical binding]; other site 1168865003167 coenzyme B12 binding site [chemical binding]; other site 1168865003168 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1168865003169 B12 binding site [chemical binding]; other site 1168865003170 cobalt ligand [ion binding]; other site 1168865003171 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1168865003172 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1168865003173 heterodimer interface [polypeptide binding]; other site 1168865003174 substrate interaction site [chemical binding]; other site 1168865003175 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1168865003176 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1168865003177 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1168865003178 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1168865003179 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1168865003180 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1168865003181 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1168865003182 ferrochelatase; Reviewed; Region: hemH; PRK00035 1168865003183 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1168865003184 C-terminal domain interface [polypeptide binding]; other site 1168865003185 active site 1168865003186 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1168865003187 active site 1168865003188 N-terminal domain interface [polypeptide binding]; other site 1168865003189 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168865003190 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168865003191 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1168865003192 aconitate hydratase; Validated; Region: PRK09277 1168865003193 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1168865003194 substrate binding site [chemical binding]; other site 1168865003195 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1168865003196 ligand binding site [chemical binding]; other site 1168865003197 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1168865003198 substrate binding site [chemical binding]; other site 1168865003199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865003200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865003201 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1168865003202 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 1168865003203 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1168865003204 catalytic triad [active] 1168865003205 conserved cys residue [active] 1168865003206 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1168865003207 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1168865003208 AAA ATPase domain; Region: AAA_16; pfam13191 1168865003209 AAA domain; Region: AAA_22; pfam13401 1168865003210 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1168865003211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865003212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865003213 Walker A/P-loop; other site 1168865003214 ATP binding site [chemical binding]; other site 1168865003215 Q-loop/lid; other site 1168865003216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865003217 ABC transporter signature motif; other site 1168865003218 Walker B; other site 1168865003219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865003220 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1168865003221 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1168865003222 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1168865003223 trimerization site [polypeptide binding]; other site 1168865003224 active site 1168865003225 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1168865003226 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1168865003227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168865003228 catalytic residue [active] 1168865003229 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1168865003230 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1168865003231 Walker A/P-loop; other site 1168865003232 ATP binding site [chemical binding]; other site 1168865003233 Q-loop/lid; other site 1168865003234 ABC transporter signature motif; other site 1168865003235 Walker B; other site 1168865003236 D-loop; other site 1168865003237 H-loop/switch region; other site 1168865003238 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1168865003239 FeS assembly protein SufD; Region: sufD; TIGR01981 1168865003240 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1168865003241 FeS assembly protein SufB; Region: sufB; TIGR01980 1168865003242 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168865003243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168865003244 putative DNA binding site [nucleotide binding]; other site 1168865003245 putative Zn2+ binding site [ion binding]; other site 1168865003246 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1168865003247 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168865003248 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168865003249 Walker A/P-loop; other site 1168865003250 ATP binding site [chemical binding]; other site 1168865003251 Q-loop/lid; other site 1168865003252 ABC transporter signature motif; other site 1168865003253 Walker B; other site 1168865003254 D-loop; other site 1168865003255 H-loop/switch region; other site 1168865003256 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168865003257 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1168865003258 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1168865003259 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1168865003260 UbiA prenyltransferase family; Region: UbiA; pfam01040 1168865003261 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1168865003262 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1168865003263 TPP-binding site [chemical binding]; other site 1168865003264 dimer interface [polypeptide binding]; other site 1168865003265 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1168865003266 PYR/PP interface [polypeptide binding]; other site 1168865003267 dimer interface [polypeptide binding]; other site 1168865003268 TPP binding site [chemical binding]; other site 1168865003269 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168865003270 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1168865003271 putative active site [active] 1168865003272 transaldolase; Provisional; Region: PRK03903 1168865003273 catalytic residue [active] 1168865003274 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1168865003275 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1168865003276 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1168865003277 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1168865003278 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1168865003279 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1168865003280 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1168865003281 putative active site [active] 1168865003282 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1168865003283 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1168865003284 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1168865003285 triosephosphate isomerase; Provisional; Region: PRK14567 1168865003286 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1168865003287 substrate binding site [chemical binding]; other site 1168865003288 dimer interface [polypeptide binding]; other site 1168865003289 catalytic triad [active] 1168865003290 Phosphoglycerate kinase; Region: PGK; pfam00162 1168865003291 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1168865003292 substrate binding site [chemical binding]; other site 1168865003293 hinge regions; other site 1168865003294 ADP binding site [chemical binding]; other site 1168865003295 catalytic site [active] 1168865003296 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1168865003297 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1168865003298 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1168865003299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1168865003300 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1168865003301 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1168865003302 dimer interface [polypeptide binding]; other site 1168865003303 phosphate binding site [ion binding]; other site 1168865003304 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1168865003305 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1168865003306 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1168865003307 GIY-YIG motif/motif A; other site 1168865003308 active site 1168865003309 catalytic site [active] 1168865003310 putative DNA binding site [nucleotide binding]; other site 1168865003311 metal binding site [ion binding]; metal-binding site 1168865003312 UvrB/uvrC motif; Region: UVR; pfam02151 1168865003313 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1168865003314 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1168865003315 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1168865003316 homopentamer interface [polypeptide binding]; other site 1168865003317 active site 1168865003318 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1168865003319 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1168865003320 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1168865003321 dimerization interface [polypeptide binding]; other site 1168865003322 active site 1168865003323 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1168865003324 Lumazine binding domain; Region: Lum_binding; pfam00677 1168865003325 Lumazine binding domain; Region: Lum_binding; pfam00677 1168865003326 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1168865003327 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1168865003328 catalytic motif [active] 1168865003329 Zn binding site [ion binding]; other site 1168865003330 RibD C-terminal domain; Region: RibD_C; pfam01872 1168865003331 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1168865003332 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1168865003333 substrate binding site [chemical binding]; other site 1168865003334 hexamer interface [polypeptide binding]; other site 1168865003335 metal binding site [ion binding]; metal-binding site 1168865003336 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1168865003337 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1168865003338 putative RNA binding site [nucleotide binding]; other site 1168865003339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865003340 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1168865003341 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1168865003342 putative active site [active] 1168865003343 substrate binding site [chemical binding]; other site 1168865003344 putative cosubstrate binding site; other site 1168865003345 catalytic site [active] 1168865003346 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1168865003347 substrate binding site [chemical binding]; other site 1168865003348 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1168865003349 active site 1168865003350 catalytic residues [active] 1168865003351 metal binding site [ion binding]; metal-binding site 1168865003352 primosome assembly protein PriA; Provisional; Region: PRK14873 1168865003353 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1168865003354 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1168865003355 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1168865003356 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1168865003357 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1168865003358 Flavoprotein; Region: Flavoprotein; pfam02441 1168865003359 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1168865003360 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1168865003361 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1168865003362 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1168865003363 catalytic site [active] 1168865003364 G-X2-G-X-G-K; other site 1168865003365 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1168865003366 active site 1168865003367 dimer interface [polypeptide binding]; other site 1168865003368 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1168865003369 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168865003370 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168865003371 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1168865003372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168865003373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168865003374 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1168865003375 IMP binding site; other site 1168865003376 dimer interface [polypeptide binding]; other site 1168865003377 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1168865003378 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1168865003379 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1168865003380 catalytic site [active] 1168865003381 subunit interface [polypeptide binding]; other site 1168865003382 dihydroorotase; Validated; Region: pyrC; PRK09357 1168865003383 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168865003384 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1168865003385 active site 1168865003386 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1168865003387 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1168865003388 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1168865003389 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1168865003390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865003391 active site 1168865003392 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1168865003393 putative hydrophobic ligand binding site [chemical binding]; other site 1168865003394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865003395 TIGR01777 family protein; Region: yfcH 1168865003396 NAD(P) binding site [chemical binding]; other site 1168865003397 active site 1168865003398 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1168865003399 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1168865003400 putative RNA binding site [nucleotide binding]; other site 1168865003401 elongation factor P; Validated; Region: PRK00529 1168865003402 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1168865003403 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1168865003404 RNA binding site [nucleotide binding]; other site 1168865003405 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1168865003406 RNA binding site [nucleotide binding]; other site 1168865003407 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168865003408 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168865003409 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1168865003410 active site 1168865003411 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1168865003412 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1168865003413 trimer interface [polypeptide binding]; other site 1168865003414 active site 1168865003415 dimer interface [polypeptide binding]; other site 1168865003416 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1168865003417 active site 1168865003418 dimer interface [polypeptide binding]; other site 1168865003419 metal binding site [ion binding]; metal-binding site 1168865003420 shikimate kinase; Reviewed; Region: aroK; PRK00131 1168865003421 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1168865003422 ADP binding site [chemical binding]; other site 1168865003423 magnesium binding site [ion binding]; other site 1168865003424 putative shikimate binding site; other site 1168865003425 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1168865003426 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1168865003427 Tetramer interface [polypeptide binding]; other site 1168865003428 active site 1168865003429 FMN-binding site [chemical binding]; other site 1168865003430 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1168865003431 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1168865003432 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1168865003433 shikimate binding site; other site 1168865003434 NAD(P) binding site [chemical binding]; other site 1168865003435 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1168865003436 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1168865003437 dimerization interface [polypeptide binding]; other site 1168865003438 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1168865003439 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1168865003440 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1168865003441 motif 1; other site 1168865003442 active site 1168865003443 motif 2; other site 1168865003444 motif 3; other site 1168865003445 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1168865003446 DHHA1 domain; Region: DHHA1; pfam02272 1168865003447 recombination factor protein RarA; Reviewed; Region: PRK13342 1168865003448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865003449 Walker A motif; other site 1168865003450 ATP binding site [chemical binding]; other site 1168865003451 Walker B motif; other site 1168865003452 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1168865003453 Phosphotransferase enzyme family; Region: APH; pfam01636 1168865003454 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1168865003455 substrate binding site [chemical binding]; other site 1168865003456 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1168865003457 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1168865003458 dimer interface [polypeptide binding]; other site 1168865003459 anticodon binding site; other site 1168865003460 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1168865003461 homodimer interface [polypeptide binding]; other site 1168865003462 motif 1; other site 1168865003463 active site 1168865003464 motif 2; other site 1168865003465 GAD domain; Region: GAD; pfam02938 1168865003466 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168865003467 active site 1168865003468 motif 3; other site 1168865003469 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168865003470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865003471 ATP binding site [chemical binding]; other site 1168865003472 putative Mg++ binding site [ion binding]; other site 1168865003473 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1168865003474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865003475 nucleotide binding region [chemical binding]; other site 1168865003476 ATP-binding site [chemical binding]; other site 1168865003477 Predicted membrane protein [Function unknown]; Region: COG1511 1168865003478 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1168865003479 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1168865003480 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1168865003481 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1168865003482 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1168865003483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865003484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865003485 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168865003486 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1168865003487 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1168865003488 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1168865003489 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1168865003490 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168865003491 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1168865003492 putative active site [active] 1168865003493 putative catalytic site [active] 1168865003494 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168865003495 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168865003496 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1168865003497 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1168865003498 dimer interface [polypeptide binding]; other site 1168865003499 motif 1; other site 1168865003500 active site 1168865003501 motif 2; other site 1168865003502 motif 3; other site 1168865003503 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1168865003504 anticodon binding site; other site 1168865003505 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1168865003506 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1168865003507 dimer interface [polypeptide binding]; other site 1168865003508 catalytic triad [active] 1168865003509 peroxidatic and resolving cysteines [active] 1168865003510 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1168865003511 active site 1168865003512 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1168865003513 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168865003514 Zn2+ binding site [ion binding]; other site 1168865003515 Mg2+ binding site [ion binding]; other site 1168865003516 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1168865003517 synthetase active site [active] 1168865003518 NTP binding site [chemical binding]; other site 1168865003519 metal binding site [ion binding]; metal-binding site 1168865003520 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1168865003521 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1168865003522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865003523 active site 1168865003524 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168865003525 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1168865003526 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1168865003527 Protein export membrane protein; Region: SecD_SecF; pfam02355 1168865003528 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1168865003529 Protein export membrane protein; Region: SecD_SecF; cl14618 1168865003530 Preprotein translocase subunit; Region: YajC; pfam02699 1168865003531 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1168865003532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865003533 Walker A motif; other site 1168865003534 ATP binding site [chemical binding]; other site 1168865003535 Walker B motif; other site 1168865003536 arginine finger; other site 1168865003537 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1168865003538 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1168865003539 RuvA N terminal domain; Region: RuvA_N; pfam01330 1168865003540 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1168865003541 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1168865003542 active site 1168865003543 putative DNA-binding cleft [nucleotide binding]; other site 1168865003544 dimer interface [polypeptide binding]; other site 1168865003545 hypothetical protein; Validated; Region: PRK00110 1168865003546 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1168865003547 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1168865003548 active site 1168865003549 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1168865003550 catalytic triad [active] 1168865003551 dimer interface [polypeptide binding]; other site 1168865003552 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1168865003553 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1168865003554 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1168865003555 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1168865003556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168865003557 catalytic residue [active] 1168865003558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168865003559 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168865003560 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1168865003561 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1168865003562 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1168865003563 putative acyl-acceptor binding pocket; other site 1168865003564 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168865003565 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1168865003566 nucleotide binding site/active site [active] 1168865003567 HIT family signature motif; other site 1168865003568 catalytic residue [active] 1168865003569 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1168865003570 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1168865003571 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1168865003572 active site 1168865003573 dimer interface [polypeptide binding]; other site 1168865003574 motif 1; other site 1168865003575 motif 2; other site 1168865003576 motif 3; other site 1168865003577 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1168865003578 anticodon binding site; other site 1168865003579 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1168865003580 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1168865003581 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1168865003582 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1168865003583 hypothetical protein; Provisional; Region: PRK14059 1168865003584 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1168865003585 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1168865003586 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1168865003587 SelR domain; Region: SelR; pfam01641 1168865003588 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1168865003589 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1168865003590 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1168865003591 catalytic site [active] 1168865003592 putative active site [active] 1168865003593 putative substrate binding site [chemical binding]; other site 1168865003594 HRDC domain; Region: HRDC; pfam00570 1168865003595 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1168865003596 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1168865003597 TPP-binding site; other site 1168865003598 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1168865003599 PYR/PP interface [polypeptide binding]; other site 1168865003600 dimer interface [polypeptide binding]; other site 1168865003601 TPP binding site [chemical binding]; other site 1168865003602 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168865003603 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1168865003604 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1168865003605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865003606 S-adenosylmethionine binding site [chemical binding]; other site 1168865003607 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1168865003608 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1168865003609 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1168865003610 trimer interface [polypeptide binding]; other site 1168865003611 active site 1168865003612 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1168865003613 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1168865003614 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168865003615 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1168865003616 active site 1168865003617 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168865003618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1168865003619 nucleotide binding site [chemical binding]; other site 1168865003620 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1168865003621 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1168865003622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865003623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168865003624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865003625 DNA binding residues [nucleotide binding] 1168865003626 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1168865003627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865003628 putative Mg++ binding site [ion binding]; other site 1168865003629 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1168865003630 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1168865003631 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1168865003632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865003633 S-adenosylmethionine binding site [chemical binding]; other site 1168865003634 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1168865003635 putative active site [active] 1168865003636 dimerization interface [polypeptide binding]; other site 1168865003637 putative tRNAtyr binding site [nucleotide binding]; other site 1168865003638 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1168865003639 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1168865003640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865003641 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168865003642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865003643 DNA binding residues [nucleotide binding] 1168865003644 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1168865003645 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1168865003646 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1168865003647 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1168865003648 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1168865003649 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1168865003650 NAD binding site [chemical binding]; other site 1168865003651 homodimer interface [polypeptide binding]; other site 1168865003652 active site 1168865003653 substrate binding site [chemical binding]; other site 1168865003654 PAC2 family; Region: PAC2; pfam09754 1168865003655 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168865003656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865003657 ATP binding site [chemical binding]; other site 1168865003658 putative Mg++ binding site [ion binding]; other site 1168865003659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865003660 nucleotide binding region [chemical binding]; other site 1168865003661 ATP-binding site [chemical binding]; other site 1168865003662 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1168865003663 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1168865003664 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168865003665 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1168865003666 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1168865003667 dimer interface [polypeptide binding]; other site 1168865003668 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1168865003669 catalytic triad [active] 1168865003670 peroxidatic and resolving cysteines [active] 1168865003671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168865003672 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1168865003673 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1168865003674 dimerization interface [polypeptide binding]; other site 1168865003675 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1168865003676 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1168865003677 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865003678 ATP binding site [chemical binding]; other site 1168865003679 putative Mg++ binding site [ion binding]; other site 1168865003680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168865003681 nucleotide binding region [chemical binding]; other site 1168865003682 ATP-binding site [chemical binding]; other site 1168865003683 Helicase associated domain (HA2); Region: HA2; pfam04408 1168865003684 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1168865003685 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1168865003686 ATP cone domain; Region: ATP-cone; pfam03477 1168865003687 LexA repressor; Validated; Region: PRK00215 1168865003688 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1168865003689 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1168865003690 Catalytic site [active] 1168865003691 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1168865003692 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1168865003693 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1168865003694 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1168865003695 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1168865003696 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1168865003697 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1168865003698 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1168865003699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168865003700 DNA-binding site [nucleotide binding]; DNA binding site 1168865003701 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1168865003702 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1168865003703 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1168865003704 putative substrate binding site [chemical binding]; other site 1168865003705 putative ATP binding site [chemical binding]; other site 1168865003706 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1168865003707 dimerization domain swap beta strand [polypeptide binding]; other site 1168865003708 regulatory protein interface [polypeptide binding]; other site 1168865003709 active site 1168865003710 regulatory phosphorylation site [posttranslational modification]; other site 1168865003711 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1168865003712 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168865003713 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168865003714 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1168865003715 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1168865003716 GTPases [General function prediction only]; Region: HflX; COG2262 1168865003717 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1168865003718 HflX GTPase family; Region: HflX; cd01878 1168865003719 G1 box; other site 1168865003720 GTP/Mg2+ binding site [chemical binding]; other site 1168865003721 Switch I region; other site 1168865003722 G2 box; other site 1168865003723 G3 box; other site 1168865003724 Switch II region; other site 1168865003725 G4 box; other site 1168865003726 G5 box; other site 1168865003727 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1168865003728 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1168865003729 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1168865003730 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1168865003731 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1168865003732 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168865003733 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168865003734 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168865003735 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1168865003736 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1168865003737 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1168865003738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865003739 FeS/SAM binding site; other site 1168865003740 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1168865003741 recombinase A; Provisional; Region: recA; PRK09354 1168865003742 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1168865003743 hexamer interface [polypeptide binding]; other site 1168865003744 Walker A motif; other site 1168865003745 ATP binding site [chemical binding]; other site 1168865003746 Walker B motif; other site 1168865003747 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1168865003748 BioY family; Region: BioY; pfam02632 1168865003749 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168865003750 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168865003751 Walker A/P-loop; other site 1168865003752 ATP binding site [chemical binding]; other site 1168865003753 Q-loop/lid; other site 1168865003754 ABC transporter signature motif; other site 1168865003755 Walker B; other site 1168865003756 D-loop; other site 1168865003757 H-loop/switch region; other site 1168865003758 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168865003759 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1168865003760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168865003761 sequence-specific DNA binding site [nucleotide binding]; other site 1168865003762 salt bridge; other site 1168865003763 Competence-damaged protein; Region: CinA; pfam02464 1168865003764 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168865003765 YCII-related domain; Region: YCII; cl00999 1168865003766 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1168865003767 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1168865003768 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168865003769 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1168865003770 TIGR03085 family protein; Region: TIGR03085 1168865003771 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1168865003772 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168865003773 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1168865003774 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1168865003775 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1168865003776 dimer interface [polypeptide binding]; other site 1168865003777 active site 1168865003778 catalytic residue [active] 1168865003779 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1168865003780 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1168865003781 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168865003782 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1168865003783 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1168865003784 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1168865003785 oligomer interface [polypeptide binding]; other site 1168865003786 RNA binding site [nucleotide binding]; other site 1168865003787 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1168865003788 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1168865003789 RNase E interface [polypeptide binding]; other site 1168865003790 trimer interface [polypeptide binding]; other site 1168865003791 active site 1168865003792 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1168865003793 putative nucleic acid binding region [nucleotide binding]; other site 1168865003794 G-X-X-G motif; other site 1168865003795 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1168865003796 RNA binding site [nucleotide binding]; other site 1168865003797 domain interface; other site 1168865003798 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1168865003799 16S/18S rRNA binding site [nucleotide binding]; other site 1168865003800 S13e-L30e interaction site [polypeptide binding]; other site 1168865003801 25S rRNA binding site [nucleotide binding]; other site 1168865003802 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1168865003803 active site 1168865003804 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1168865003805 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1168865003806 active site 1168865003807 Riboflavin kinase; Region: Flavokinase; smart00904 1168865003808 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1168865003809 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1168865003810 RNA binding site [nucleotide binding]; other site 1168865003811 active site 1168865003812 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1168865003813 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1168865003814 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1168865003815 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1168865003816 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1168865003817 active site 1168865003818 metal binding site [ion binding]; metal-binding site 1168865003819 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1168865003820 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1168865003821 DHH family; Region: DHH; pfam01368 1168865003822 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1168865003823 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1168865003824 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1168865003825 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1168865003826 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1168865003827 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1168865003828 G1 box; other site 1168865003829 putative GEF interaction site [polypeptide binding]; other site 1168865003830 GTP/Mg2+ binding site [chemical binding]; other site 1168865003831 Switch I region; other site 1168865003832 G2 box; other site 1168865003833 G3 box; other site 1168865003834 Switch II region; other site 1168865003835 G4 box; other site 1168865003836 G5 box; other site 1168865003837 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1168865003838 Translation-initiation factor 2; Region: IF-2; pfam11987 1168865003839 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1168865003840 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1168865003841 putative RNA binding cleft [nucleotide binding]; other site 1168865003842 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1168865003843 NusA N-terminal domain; Region: NusA_N; pfam08529 1168865003844 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1168865003845 RNA binding site [nucleotide binding]; other site 1168865003846 homodimer interface [polypeptide binding]; other site 1168865003847 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1168865003848 G-X-X-G motif; other site 1168865003849 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1168865003850 G-X-X-G motif; other site 1168865003851 Sm and related proteins; Region: Sm_like; cl00259 1168865003852 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1168865003853 heptamer interface [polypeptide binding]; other site 1168865003854 Sm1 motif; other site 1168865003855 hexamer interface [polypeptide binding]; other site 1168865003856 RNA binding site [nucleotide binding]; other site 1168865003857 Sm2 motif; other site 1168865003858 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1168865003859 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1168865003860 dimer interface [polypeptide binding]; other site 1168865003861 motif 1; other site 1168865003862 active site 1168865003863 motif 2; other site 1168865003864 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1168865003865 putative deacylase active site [active] 1168865003866 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168865003867 active site 1168865003868 motif 3; other site 1168865003869 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1168865003870 anticodon binding site; other site 1168865003871 hypothetical protein; Validated; Region: PRK02101 1168865003872 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1168865003873 active site 1168865003874 SAM binding site [chemical binding]; other site 1168865003875 homodimer interface [polypeptide binding]; other site 1168865003876 hypothetical protein; Validated; Region: PRK00029 1168865003877 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1168865003878 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1168865003879 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1168865003880 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1168865003881 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1168865003882 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1168865003883 DNA binding site [nucleotide binding] 1168865003884 active site 1168865003885 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1168865003886 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1168865003887 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1168865003888 catalytic triad [active] 1168865003889 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1168865003890 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1168865003891 homodimer interface [polypeptide binding]; other site 1168865003892 Walker A motif; other site 1168865003893 ATP binding site [chemical binding]; other site 1168865003894 hydroxycobalamin binding site [chemical binding]; other site 1168865003895 Walker B motif; other site 1168865003896 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1168865003897 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1168865003898 metal ion-dependent adhesion site (MIDAS); other site 1168865003899 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1168865003900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865003901 Walker A motif; other site 1168865003902 ATP binding site [chemical binding]; other site 1168865003903 Walker B motif; other site 1168865003904 arginine finger; other site 1168865003905 malate:quinone oxidoreductase; Validated; Region: PRK05257 1168865003906 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1168865003907 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1168865003908 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168865003909 mycothione reductase; Reviewed; Region: PRK07846 1168865003910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168865003911 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168865003912 cobyric acid synthase; Provisional; Region: PRK00784 1168865003913 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168865003914 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1168865003915 catalytic triad [active] 1168865003916 methionine aminopeptidase; Provisional; Region: PRK12318 1168865003917 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1168865003918 active site 1168865003919 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1168865003920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168865003921 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1168865003922 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1168865003923 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1168865003924 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1168865003925 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1168865003926 active site 1168865003927 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1168865003928 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1168865003929 putative substrate binding region [chemical binding]; other site 1168865003930 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1168865003931 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1168865003932 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1168865003933 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1168865003934 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1168865003935 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1168865003936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865003937 FeS/SAM binding site; other site 1168865003938 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1168865003939 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1168865003940 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1168865003941 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1168865003942 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1168865003943 hinge region; other site 1168865003944 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1168865003945 putative nucleotide binding site [chemical binding]; other site 1168865003946 uridine monophosphate binding site [chemical binding]; other site 1168865003947 homohexameric interface [polypeptide binding]; other site 1168865003948 elongation factor Ts; Provisional; Region: tsf; PRK09377 1168865003949 UBA/TS-N domain; Region: UBA; pfam00627 1168865003950 Elongation factor TS; Region: EF_TS; pfam00889 1168865003951 Elongation factor TS; Region: EF_TS; pfam00889 1168865003952 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1168865003953 rRNA interaction site [nucleotide binding]; other site 1168865003954 S8 interaction site; other site 1168865003955 putative laminin-1 binding site; other site 1168865003956 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1168865003957 Peptidase family M23; Region: Peptidase_M23; pfam01551 1168865003958 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1168865003959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168865003960 active site 1168865003961 DNA binding site [nucleotide binding] 1168865003962 Int/Topo IB signature motif; other site 1168865003963 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1168865003964 DNA protecting protein DprA; Region: dprA; TIGR00732 1168865003965 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1168865003966 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1168865003967 RNA/DNA hybrid binding site [nucleotide binding]; other site 1168865003968 active site 1168865003969 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1168865003970 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1168865003971 Catalytic site [active] 1168865003972 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1168865003973 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1168865003974 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1168865003975 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1168865003976 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1168865003977 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1168865003978 RNA binding site [nucleotide binding]; other site 1168865003979 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1168865003980 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1168865003981 active site 1168865003982 P-loop; other site 1168865003983 phosphorylation site [posttranslational modification] 1168865003984 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1168865003985 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1168865003986 active site 1168865003987 phosphorylation site [posttranslational modification] 1168865003988 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1168865003989 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1168865003990 RimM N-terminal domain; Region: RimM; pfam01782 1168865003991 PRC-barrel domain; Region: PRC; pfam05239 1168865003992 Cupin domain; Region: Cupin_2; cl17218 1168865003993 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1168865003994 signal recognition particle protein; Provisional; Region: PRK10867 1168865003995 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1168865003996 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1168865003997 P loop; other site 1168865003998 GTP binding site [chemical binding]; other site 1168865003999 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1168865004000 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1168865004001 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168865004002 metal binding triad; other site 1168865004003 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168865004004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168865004005 Zn2+ binding site [ion binding]; other site 1168865004006 Mg2+ binding site [ion binding]; other site 1168865004007 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1168865004008 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1168865004009 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1168865004010 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1168865004011 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168865004012 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1168865004013 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1168865004014 Walker A/P-loop; other site 1168865004015 ATP binding site [chemical binding]; other site 1168865004016 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1168865004017 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1168865004018 ABC transporter signature motif; other site 1168865004019 Walker B; other site 1168865004020 D-loop; other site 1168865004021 H-loop/switch region; other site 1168865004022 Acylphosphatase; Region: Acylphosphatase; cl00551 1168865004023 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1168865004024 amino acid carrier protein; Region: agcS; TIGR00835 1168865004025 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1168865004026 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1168865004027 DNA binding site [nucleotide binding] 1168865004028 catalytic residue [active] 1168865004029 H2TH interface [polypeptide binding]; other site 1168865004030 putative catalytic residues [active] 1168865004031 turnover-facilitating residue; other site 1168865004032 intercalation triad [nucleotide binding]; other site 1168865004033 8OG recognition residue [nucleotide binding]; other site 1168865004034 putative reading head residues; other site 1168865004035 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168865004036 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168865004037 ribonuclease III; Reviewed; Region: rnc; PRK00102 1168865004038 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1168865004039 dimerization interface [polypeptide binding]; other site 1168865004040 active site 1168865004041 metal binding site [ion binding]; metal-binding site 1168865004042 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1168865004043 dsRNA binding site [nucleotide binding]; other site 1168865004044 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1168865004045 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1168865004046 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168865004047 RibD C-terminal domain; Region: RibD_C; cl17279 1168865004048 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1168865004049 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1168865004050 hexamer interface [polypeptide binding]; other site 1168865004051 ligand binding site [chemical binding]; other site 1168865004052 putative active site [active] 1168865004053 NAD(P) binding site [chemical binding]; other site 1168865004054 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1168865004055 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1168865004056 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1168865004057 nucleotide binding site/active site [active] 1168865004058 HIT family signature motif; other site 1168865004059 catalytic residue [active] 1168865004060 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1168865004061 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1168865004062 metal binding site [ion binding]; metal-binding site 1168865004063 putative dimer interface [polypeptide binding]; other site 1168865004064 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1168865004065 homodimer interface [polypeptide binding]; other site 1168865004066 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1168865004067 active site pocket [active] 1168865004068 Electron transfer DM13; Region: DM13; pfam10517 1168865004069 pyruvate kinase; Provisional; Region: PRK06247 1168865004070 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1168865004071 domain interfaces; other site 1168865004072 active site 1168865004073 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1168865004074 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1168865004075 active site 1168865004076 ribulose/triose binding site [chemical binding]; other site 1168865004077 phosphate binding site [ion binding]; other site 1168865004078 substrate (anthranilate) binding pocket [chemical binding]; other site 1168865004079 product (indole) binding pocket [chemical binding]; other site 1168865004080 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1168865004081 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1168865004082 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1168865004083 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1168865004084 substrate binding site [chemical binding]; other site 1168865004085 glutamase interaction surface [polypeptide binding]; other site 1168865004086 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1168865004087 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168865004088 active site 1168865004089 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1168865004090 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1168865004091 catalytic residues [active] 1168865004092 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1168865004093 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1168865004094 putative active site [active] 1168865004095 oxyanion strand; other site 1168865004096 catalytic triad [active] 1168865004097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865004098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168865004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865004100 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1168865004101 putative active site pocket [active] 1168865004102 4-fold oligomerization interface [polypeptide binding]; other site 1168865004103 metal binding residues [ion binding]; metal-binding site 1168865004104 3-fold/trimer interface [polypeptide binding]; other site 1168865004105 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1168865004106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865004108 homodimer interface [polypeptide binding]; other site 1168865004109 catalytic residue [active] 1168865004110 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1168865004111 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1168865004112 NAD binding site [chemical binding]; other site 1168865004113 dimerization interface [polypeptide binding]; other site 1168865004114 product binding site; other site 1168865004115 substrate binding site [chemical binding]; other site 1168865004116 zinc binding site [ion binding]; other site 1168865004117 catalytic residues [active] 1168865004118 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1168865004119 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1168865004120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865004121 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168865004122 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1168865004123 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1168865004124 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1168865004125 active site 1168865004126 catalytic site [active] 1168865004127 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1168865004128 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1168865004129 active site 1168865004130 catalytic site [active] 1168865004131 substrate binding site [chemical binding]; other site 1168865004132 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1168865004133 Dimer interface [polypeptide binding]; other site 1168865004134 BRCT sequence motif; other site 1168865004135 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1168865004136 synthetase active site [active] 1168865004137 NTP binding site [chemical binding]; other site 1168865004138 metal binding site [ion binding]; metal-binding site 1168865004139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865004140 RNA binding surface [nucleotide binding]; other site 1168865004141 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1168865004142 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1168865004143 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1168865004144 threonine dehydratase; Validated; Region: PRK08639 1168865004145 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1168865004146 tetramer interface [polypeptide binding]; other site 1168865004147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865004148 catalytic residue [active] 1168865004149 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1168865004150 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1168865004151 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1168865004152 active site 1168865004153 PHP Thumb interface [polypeptide binding]; other site 1168865004154 metal binding site [ion binding]; metal-binding site 1168865004155 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1168865004156 generic binding surface I; other site 1168865004157 generic binding surface II; other site 1168865004158 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1168865004159 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1168865004160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168865004161 RNA binding surface [nucleotide binding]; other site 1168865004162 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1168865004163 active site 1168865004164 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1168865004165 lipoprotein signal peptidase; Provisional; Region: PRK14787 1168865004166 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1168865004167 active site 1168865004168 homotetramer interface [polypeptide binding]; other site 1168865004169 homodimer interface [polypeptide binding]; other site 1168865004170 DNA polymerase IV; Provisional; Region: PRK03348 1168865004171 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1168865004172 active site 1168865004173 DNA binding site [nucleotide binding] 1168865004174 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1168865004175 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1168865004176 HIGH motif; other site 1168865004177 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1168865004178 active site 1168865004179 KMSKS motif; other site 1168865004180 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1168865004181 tRNA binding surface [nucleotide binding]; other site 1168865004182 anticodon binding site; other site 1168865004183 DivIVA protein; Region: DivIVA; pfam05103 1168865004184 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168865004185 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1168865004186 YGGT family; Region: YGGT; pfam02325 1168865004187 Protein of unknown function (DUF552); Region: DUF552; cl00775 1168865004188 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1168865004189 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1168865004190 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1168865004191 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1168865004192 nucleotide binding site [chemical binding]; other site 1168865004193 SulA interaction site; other site 1168865004194 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1168865004195 Cell division protein FtsQ; Region: FtsQ; pfam03799 1168865004196 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1168865004197 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168865004198 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865004199 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168865004200 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1168865004201 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1168865004202 homodimer interface [polypeptide binding]; other site 1168865004203 active site 1168865004204 cell division protein FtsW; Region: ftsW; TIGR02614 1168865004205 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1168865004206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865004207 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1168865004208 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1168865004209 Mg++ binding site [ion binding]; other site 1168865004210 putative catalytic motif [active] 1168865004211 putative substrate binding site [chemical binding]; other site 1168865004212 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1168865004213 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168865004214 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865004215 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168865004216 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1168865004217 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168865004218 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865004219 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168865004220 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168865004221 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1168865004222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168865004223 MraW methylase family; Region: Methyltransf_5; cl17771 1168865004224 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1168865004225 cell division protein MraZ; Reviewed; Region: PRK00326 1168865004226 MraZ protein; Region: MraZ; pfam02381 1168865004227 MraZ protein; Region: MraZ; pfam02381 1168865004228 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1168865004229 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1168865004230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1168865004231 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1168865004232 FAD binding site [chemical binding]; other site 1168865004233 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1168865004234 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1168865004235 substrate binding pocket [chemical binding]; other site 1168865004236 chain length determination region; other site 1168865004237 substrate-Mg2+ binding site; other site 1168865004238 catalytic residues [active] 1168865004239 aspartate-rich region 1; other site 1168865004240 active site lid residues [active] 1168865004241 aspartate-rich region 2; other site 1168865004242 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1168865004243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168865004244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168865004245 active site 1168865004246 ATP binding site [chemical binding]; other site 1168865004247 substrate binding site [chemical binding]; other site 1168865004248 activation loop (A-loop); other site 1168865004249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1168865004250 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865004251 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865004252 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865004253 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865004254 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168865004255 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1168865004256 Predicted membrane protein [Function unknown]; Region: COG4763 1168865004257 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1168865004258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168865004259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168865004260 putative acyl-acceptor binding pocket; other site 1168865004261 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168865004262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1168865004263 nucleotide binding site [chemical binding]; other site 1168865004264 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168865004265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168865004266 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168865004267 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168865004268 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168865004269 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168865004270 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1168865004271 heme bH binding site [chemical binding]; other site 1168865004272 intrachain domain interface; other site 1168865004273 heme bL binding site [chemical binding]; other site 1168865004274 interchain domain interface [polypeptide binding]; other site 1168865004275 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1168865004276 Qo binding site; other site 1168865004277 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1168865004278 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1168865004279 iron-sulfur cluster [ion binding]; other site 1168865004280 [2Fe-2S] cluster binding site [ion binding]; other site 1168865004281 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1168865004282 Cytochrome c; Region: Cytochrom_C; pfam00034 1168865004283 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1168865004284 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1168865004285 Subunit I/III interface [polypeptide binding]; other site 1168865004286 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1168865004287 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1168865004288 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1168865004289 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1168865004290 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1168865004291 active site 1168865004292 dimer interface [polypeptide binding]; other site 1168865004293 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1168865004294 Ligand Binding Site [chemical binding]; other site 1168865004295 Molecular Tunnel; other site 1168865004296 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1168865004297 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1168865004298 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1168865004299 homotrimer interface [polypeptide binding]; other site 1168865004300 Walker A motif; other site 1168865004301 GTP binding site [chemical binding]; other site 1168865004302 Walker B motif; other site 1168865004303 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1168865004304 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1168865004305 putative dimer interface [polypeptide binding]; other site 1168865004306 active site pocket [active] 1168865004307 putative cataytic base [active] 1168865004308 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1168865004309 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1168865004310 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1168865004311 homodimer interface [polypeptide binding]; other site 1168865004312 substrate-cofactor binding pocket; other site 1168865004313 catalytic residue [active] 1168865004314 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1168865004315 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1168865004316 interface (dimer of trimers) [polypeptide binding]; other site 1168865004317 Substrate-binding/catalytic site; other site 1168865004318 Zn-binding sites [ion binding]; other site 1168865004319 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1168865004320 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168865004321 E3 interaction surface; other site 1168865004322 lipoyl attachment site [posttranslational modification]; other site 1168865004323 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168865004324 E3 interaction surface; other site 1168865004325 lipoyl attachment site [posttranslational modification]; other site 1168865004326 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168865004327 E3 interaction surface; other site 1168865004328 lipoyl attachment site [posttranslational modification]; other site 1168865004329 e3 binding domain; Region: E3_binding; pfam02817 1168865004330 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1168865004331 glycine dehydrogenase; Provisional; Region: PRK05367 1168865004332 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1168865004333 tetramer interface [polypeptide binding]; other site 1168865004334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865004335 catalytic residue [active] 1168865004336 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1168865004337 tetramer interface [polypeptide binding]; other site 1168865004338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865004339 catalytic residue [active] 1168865004340 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1168865004341 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1168865004342 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1168865004343 lipoyl attachment site [posttranslational modification]; other site 1168865004344 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168865004345 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168865004346 active site 1168865004347 lipoate-protein ligase B; Provisional; Region: PRK14345 1168865004348 lipoyl synthase; Provisional; Region: PRK05481 1168865004349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865004350 FeS/SAM binding site; other site 1168865004351 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1168865004352 RDD family; Region: RDD; pfam06271 1168865004353 glutamine synthetase, type I; Region: GlnA; TIGR00653 1168865004354 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1168865004355 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168865004356 Htaa; Region: HtaA; pfam04213 1168865004357 Htaa; Region: HtaA; pfam04213 1168865004358 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1168865004359 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1168865004360 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1168865004361 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1168865004362 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1168865004363 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1168865004364 active site 1168865004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1168865004366 Predicted permease [General function prediction only]; Region: COG2056 1168865004367 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1168865004368 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1168865004369 nudix motif; other site 1168865004370 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1168865004371 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1168865004372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865004373 catalytic residue [active] 1168865004374 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1168865004375 active site 1168865004376 catalytic site [active] 1168865004377 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1168865004378 heme binding pocket [chemical binding]; other site 1168865004379 heme ligand [chemical binding]; other site 1168865004380 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1168865004381 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168865004382 metal binding triad; other site 1168865004383 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168865004384 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168865004385 metal binding triad; other site 1168865004386 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168865004387 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1168865004388 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1168865004389 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168865004390 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1168865004391 putative active site; other site 1168865004392 putative metal binding residues [ion binding]; other site 1168865004393 signature motif; other site 1168865004394 putative triphosphate binding site [ion binding]; other site 1168865004395 CHAD domain; Region: CHAD; pfam05235 1168865004396 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1168865004397 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1168865004398 RNB domain; Region: RNB; pfam00773 1168865004399 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1168865004400 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1168865004401 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1168865004402 RNA/DNA hybrid binding site [nucleotide binding]; other site 1168865004403 active site 1168865004404 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865004405 catalytic core [active] 1168865004406 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1168865004407 Putative zinc ribbon domain; Region: DUF164; pfam02591 1168865004408 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1168865004409 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1168865004410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1168865004411 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1168865004412 hypothetical protein; Provisional; Region: PRK07908 1168865004413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865004414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865004415 homodimer interface [polypeptide binding]; other site 1168865004416 catalytic residue [active] 1168865004417 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1168865004418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865004419 motif II; other site 1168865004420 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1168865004421 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1168865004422 active site 1168865004423 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1168865004424 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1168865004425 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1168865004426 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1168865004427 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1168865004428 dimer interface [polypeptide binding]; other site 1168865004429 TPP-binding site [chemical binding]; other site 1168865004430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168865004431 Serine hydrolase; Region: Ser_hydrolase; cl17834 1168865004432 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1168865004433 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1168865004434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865004435 active site 1168865004436 motif I; other site 1168865004437 motif II; other site 1168865004438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865004439 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168865004440 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168865004441 Predicted membrane protein [Function unknown]; Region: COG2860 1168865004442 UPF0126 domain; Region: UPF0126; pfam03458 1168865004443 UPF0126 domain; Region: UPF0126; pfam03458 1168865004444 DNA primase; Validated; Region: dnaG; PRK05667 1168865004445 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1168865004446 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1168865004447 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1168865004448 active site 1168865004449 metal binding site [ion binding]; metal-binding site 1168865004450 interdomain interaction site; other site 1168865004451 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1168865004452 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1168865004453 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1168865004454 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1168865004455 glutaminase active site [active] 1168865004456 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1168865004457 dimer interface [polypeptide binding]; other site 1168865004458 active site 1168865004459 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1168865004460 dimer interface [polypeptide binding]; other site 1168865004461 active site 1168865004462 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1168865004463 active site 1168865004464 barstar interaction site; other site 1168865004465 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1168865004466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168865004467 Zn2+ binding site [ion binding]; other site 1168865004468 Mg2+ binding site [ion binding]; other site 1168865004469 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1168865004470 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1168865004471 putative active site [active] 1168865004472 Repair protein; Region: Repair_PSII; pfam04536 1168865004473 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1168865004474 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168865004475 motif 1; other site 1168865004476 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1168865004477 active site 1168865004478 motif 2; other site 1168865004479 motif 3; other site 1168865004480 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1168865004481 anticodon binding site; other site 1168865004482 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1168865004483 metal binding site 2 [ion binding]; metal-binding site 1168865004484 putative DNA binding helix; other site 1168865004485 metal binding site 1 [ion binding]; metal-binding site 1168865004486 dimer interface [polypeptide binding]; other site 1168865004487 structural Zn2+ binding site [ion binding]; other site 1168865004488 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1168865004489 diiron binding motif [ion binding]; other site 1168865004490 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1168865004491 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1168865004492 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1168865004493 catalytic residue [active] 1168865004494 putative FPP diphosphate binding site; other site 1168865004495 putative FPP binding hydrophobic cleft; other site 1168865004496 dimer interface [polypeptide binding]; other site 1168865004497 putative IPP diphosphate binding site; other site 1168865004498 Recombination protein O N terminal; Region: RecO_N; pfam11967 1168865004499 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1168865004500 Recombination protein O C terminal; Region: RecO_C; pfam02565 1168865004501 GTPase Era; Reviewed; Region: era; PRK00089 1168865004502 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1168865004503 G1 box; other site 1168865004504 GTP/Mg2+ binding site [chemical binding]; other site 1168865004505 Switch I region; other site 1168865004506 G2 box; other site 1168865004507 Switch II region; other site 1168865004508 G3 box; other site 1168865004509 G4 box; other site 1168865004510 G5 box; other site 1168865004511 KH domain; Region: KH_2; pfam07650 1168865004512 pyridoxamine kinase; Validated; Region: PRK05756 1168865004513 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1168865004514 dimer interface [polypeptide binding]; other site 1168865004515 pyridoxal binding site [chemical binding]; other site 1168865004516 ATP binding site [chemical binding]; other site 1168865004517 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168865004518 FOG: CBS domain [General function prediction only]; Region: COG0517 1168865004519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168865004520 Transporter associated domain; Region: CorC_HlyC; smart01091 1168865004521 metal-binding heat shock protein; Provisional; Region: PRK00016 1168865004522 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1168865004523 PhoH-like protein; Region: PhoH; pfam02562 1168865004524 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1168865004525 RNA methyltransferase, RsmE family; Region: TIGR00046 1168865004526 chaperone protein DnaJ; Provisional; Region: PRK14278 1168865004527 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1168865004528 HSP70 interaction site [polypeptide binding]; other site 1168865004529 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1168865004530 Zn binding sites [ion binding]; other site 1168865004531 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1168865004532 dimer interface [polypeptide binding]; other site 1168865004533 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1168865004534 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1168865004535 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1168865004536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168865004537 FeS/SAM binding site; other site 1168865004538 HemN C-terminal domain; Region: HemN_C; pfam06969 1168865004539 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168865004540 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168865004541 acyl-activating enzyme (AAE) consensus motif; other site 1168865004542 putative AMP binding site [chemical binding]; other site 1168865004543 putative active site [active] 1168865004544 putative CoA binding site [chemical binding]; other site 1168865004545 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1168865004546 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1168865004547 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1168865004548 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1168865004549 active site 1168865004550 Zn binding site [ion binding]; other site 1168865004551 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168865004552 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1168865004553 substrate binding pocket [chemical binding]; other site 1168865004554 catalytic triad [active] 1168865004555 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1168865004556 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1168865004557 active site 1168865004558 metal binding site [ion binding]; metal-binding site 1168865004559 nudix motif; other site 1168865004560 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168865004561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168865004562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865004563 Walker A/P-loop; other site 1168865004564 ATP binding site [chemical binding]; other site 1168865004565 Q-loop/lid; other site 1168865004566 ABC transporter signature motif; other site 1168865004567 Walker B; other site 1168865004568 D-loop; other site 1168865004569 H-loop/switch region; other site 1168865004570 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1168865004571 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1168865004572 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168865004573 BCCT family transporter; Region: BCCT; pfam02028 1168865004574 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1168865004575 Predicted permeases [General function prediction only]; Region: COG0679 1168865004576 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168865004577 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1168865004578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865004579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865004580 dimer interface [polypeptide binding]; other site 1168865004581 conserved gate region; other site 1168865004582 putative PBP binding loops; other site 1168865004583 ABC-ATPase subunit interface; other site 1168865004584 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1168865004585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865004586 dimer interface [polypeptide binding]; other site 1168865004587 conserved gate region; other site 1168865004588 putative PBP binding loops; other site 1168865004589 ABC-ATPase subunit interface; other site 1168865004590 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168865004591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865004592 Walker A/P-loop; other site 1168865004593 ATP binding site [chemical binding]; other site 1168865004594 Q-loop/lid; other site 1168865004595 ABC transporter signature motif; other site 1168865004596 Walker B; other site 1168865004597 D-loop; other site 1168865004598 H-loop/switch region; other site 1168865004599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865004600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865004601 Walker A/P-loop; other site 1168865004602 ATP binding site [chemical binding]; other site 1168865004603 Q-loop/lid; other site 1168865004604 ABC transporter signature motif; other site 1168865004605 Walker B; other site 1168865004606 D-loop; other site 1168865004607 H-loop/switch region; other site 1168865004608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865004609 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1168865004610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1168865004611 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168865004612 catalytic residue [active] 1168865004613 Sulphur transport; Region: Sulf_transp; pfam04143 1168865004614 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1168865004615 CPxP motif; other site 1168865004616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865004617 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1168865004618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168865004619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1168865004620 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168865004621 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1168865004622 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168865004623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865004624 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1168865004625 Walker A/P-loop; other site 1168865004626 ATP binding site [chemical binding]; other site 1168865004627 Q-loop/lid; other site 1168865004628 ABC transporter signature motif; other site 1168865004629 Walker B; other site 1168865004630 D-loop; other site 1168865004631 H-loop/switch region; other site 1168865004632 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168865004633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865004634 Walker A/P-loop; other site 1168865004635 ATP binding site [chemical binding]; other site 1168865004636 Q-loop/lid; other site 1168865004637 ABC transporter signature motif; other site 1168865004638 Walker B; other site 1168865004639 D-loop; other site 1168865004640 H-loop/switch region; other site 1168865004641 GTP-binding protein LepA; Provisional; Region: PRK05433 1168865004642 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1168865004643 G1 box; other site 1168865004644 putative GEF interaction site [polypeptide binding]; other site 1168865004645 GTP/Mg2+ binding site [chemical binding]; other site 1168865004646 Switch I region; other site 1168865004647 G2 box; other site 1168865004648 G3 box; other site 1168865004649 Switch II region; other site 1168865004650 G4 box; other site 1168865004651 G5 box; other site 1168865004652 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1168865004653 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1168865004654 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1168865004655 PemK-like protein; Region: PemK; pfam02452 1168865004656 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1168865004657 LysE type translocator; Region: LysE; cl00565 1168865004658 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1168865004659 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1168865004660 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1168865004661 hypothetical protein; Validated; Region: PRK05629 1168865004662 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1168865004663 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1168865004664 Competence protein; Region: Competence; pfam03772 1168865004665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1168865004666 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1168865004667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865004668 catalytic core [active] 1168865004669 Oligomerisation domain; Region: Oligomerisation; pfam02410 1168865004670 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1168865004671 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1168865004672 active site 1168865004673 (T/H)XGH motif; other site 1168865004674 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1168865004675 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1168865004676 putative catalytic cysteine [active] 1168865004677 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1168865004678 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1168865004679 putative ligand binding site [chemical binding]; other site 1168865004680 putative NAD binding site [chemical binding]; other site 1168865004681 catalytic site [active] 1168865004682 Protein of unknown function (DUF454); Region: DUF454; cl01063 1168865004683 Predicted permease [General function prediction only]; Region: COG2985 1168865004684 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1168865004685 TrkA-C domain; Region: TrkA_C; pfam02080 1168865004686 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1168865004687 gamma-glutamyl kinase; Provisional; Region: PRK05429 1168865004688 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1168865004689 nucleotide binding site [chemical binding]; other site 1168865004690 homotetrameric interface [polypeptide binding]; other site 1168865004691 putative phosphate binding site [ion binding]; other site 1168865004692 putative allosteric binding site; other site 1168865004693 PUA domain; Region: PUA; pfam01472 1168865004694 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1168865004695 GTP1/OBG; Region: GTP1_OBG; pfam01018 1168865004696 Obg GTPase; Region: Obg; cd01898 1168865004697 G1 box; other site 1168865004698 GTP/Mg2+ binding site [chemical binding]; other site 1168865004699 Switch I region; other site 1168865004700 G2 box; other site 1168865004701 G3 box; other site 1168865004702 Switch II region; other site 1168865004703 G4 box; other site 1168865004704 G5 box; other site 1168865004705 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1168865004706 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1168865004707 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1168865004708 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1168865004709 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1168865004710 homodimer interface [polypeptide binding]; other site 1168865004711 oligonucleotide binding site [chemical binding]; other site 1168865004712 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1168865004713 active site 1168865004714 multimer interface [polypeptide binding]; other site 1168865004715 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1168865004716 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1168865004717 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1168865004718 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1168865004719 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865004720 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168865004721 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168865004722 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1168865004723 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168865004724 active site 1168865004725 HIGH motif; other site 1168865004726 nucleotide binding site [chemical binding]; other site 1168865004727 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1168865004728 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1168865004729 active site 1168865004730 KMSKS motif; other site 1168865004731 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1168865004732 tRNA binding surface [nucleotide binding]; other site 1168865004733 anticodon binding site; other site 1168865004734 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1168865004735 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1168865004736 malate dehydrogenase; Provisional; Region: PRK05442 1168865004737 NAD(P) binding site [chemical binding]; other site 1168865004738 dimer interface [polypeptide binding]; other site 1168865004739 malate binding site [chemical binding]; other site 1168865004740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865004741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865004742 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1168865004743 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1168865004744 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1168865004745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865004746 Walker A motif; other site 1168865004747 ATP binding site [chemical binding]; other site 1168865004748 Walker B motif; other site 1168865004749 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1168865004750 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1168865004751 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1168865004752 glutamine binding [chemical binding]; other site 1168865004753 catalytic triad [active] 1168865004754 hypothetical protein; Validated; Region: PRK09070 1168865004755 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168865004756 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1168865004757 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1168865004758 substrate-cofactor binding pocket; other site 1168865004759 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1168865004760 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1168865004761 oligomer interface [polypeptide binding]; other site 1168865004762 active site residues [active] 1168865004763 Clp protease; Region: CLP_protease; pfam00574 1168865004764 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1168865004765 oligomer interface [polypeptide binding]; other site 1168865004766 active site residues [active] 1168865004767 trigger factor; Provisional; Region: tig; PRK01490 1168865004768 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168865004769 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1168865004770 Pirin-related protein [General function prediction only]; Region: COG1741 1168865004771 Pirin; Region: Pirin; pfam02678 1168865004772 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1168865004773 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1168865004774 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1168865004775 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1168865004776 catalytic residues [active] 1168865004777 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1168865004778 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1168865004779 Zn binding site [ion binding]; other site 1168865004780 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1168865004781 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1168865004782 apolar tunnel; other site 1168865004783 heme binding site [chemical binding]; other site 1168865004784 dimerization interface [polypeptide binding]; other site 1168865004785 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1168865004786 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1168865004787 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1168865004788 active site 1168865004789 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1168865004790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865004791 Walker A/P-loop; other site 1168865004792 ATP binding site [chemical binding]; other site 1168865004793 Q-loop/lid; other site 1168865004794 ABC transporter signature motif; other site 1168865004795 Walker B; other site 1168865004796 D-loop; other site 1168865004797 H-loop/switch region; other site 1168865004798 ABC transporter; Region: ABC_tran_2; pfam12848 1168865004799 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168865004800 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1168865004801 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1168865004802 dimer interface [polypeptide binding]; other site 1168865004803 ssDNA binding site [nucleotide binding]; other site 1168865004804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168865004805 YcaO-like family; Region: YcaO; pfam02624 1168865004806 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1168865004807 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1168865004808 NADPH bind site [chemical binding]; other site 1168865004809 Nitroreductase family; Region: Nitroreductase; pfam00881 1168865004810 dimer interface [polypeptide binding]; other site 1168865004811 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1168865004812 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1168865004813 YcaO-like family; Region: YcaO; pfam02624 1168865004814 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1168865004815 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168865004816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168865004817 Walker A/P-loop; other site 1168865004818 ATP binding site [chemical binding]; other site 1168865004819 Q-loop/lid; other site 1168865004820 ABC transporter signature motif; other site 1168865004821 Walker B; other site 1168865004822 D-loop; other site 1168865004823 H-loop/switch region; other site 1168865004824 Copper resistance protein D; Region: CopD; pfam05425 1168865004825 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1168865004826 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1168865004827 Carbon starvation protein CstA; Region: CstA; pfam02554 1168865004828 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1168865004829 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1168865004830 active site 1168865004831 catalytic triad [active] 1168865004832 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1168865004833 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1168865004834 NADP binding site [chemical binding]; other site 1168865004835 dimer interface [polypeptide binding]; other site 1168865004836 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168865004837 classical (c) SDRs; Region: SDR_c; cd05233 1168865004838 NAD(P) binding site [chemical binding]; other site 1168865004839 active site 1168865004840 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1168865004841 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1168865004842 catalytic site [active] 1168865004843 putative active site [active] 1168865004844 putative substrate binding site [chemical binding]; other site 1168865004845 dimer interface [polypeptide binding]; other site 1168865004846 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1168865004847 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1168865004848 active site 1168865004849 inhibitor site; inhibition site 1168865004850 dimer interface [polypeptide binding]; other site 1168865004851 catalytic residue [active] 1168865004852 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1168865004853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168865004854 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1168865004855 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168865004856 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1168865004857 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1168865004858 catalytic residues [active] 1168865004859 catalytic nucleophile [active] 1168865004860 Presynaptic Site I dimer interface [polypeptide binding]; other site 1168865004861 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1168865004862 Synaptic Flat tetramer interface [polypeptide binding]; other site 1168865004863 Synaptic Site I dimer interface [polypeptide binding]; other site 1168865004864 DNA binding site [nucleotide binding] 1168865004865 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1168865004866 DNA-binding interface [nucleotide binding]; DNA binding site 1168865004867 aldehyde dehydrogenase; Provisional; Region: PRK11903 1168865004868 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1168865004869 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1168865004870 NAD(P) binding site [chemical binding]; other site 1168865004871 substrate binding site [chemical binding]; other site 1168865004872 dimer interface [polypeptide binding]; other site 1168865004873 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1168865004874 Isochorismatase family; Region: Isochorismatase; pfam00857 1168865004875 catalytic triad [active] 1168865004876 metal binding site [ion binding]; metal-binding site 1168865004877 conserved cis-peptide bond; other site 1168865004878 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1168865004879 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1168865004880 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1168865004881 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1168865004882 catalytic triad [active] 1168865004883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865004884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865004885 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1168865004886 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168865004887 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168865004888 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1168865004889 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168865004890 phosphate binding site [ion binding]; other site 1168865004891 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1168865004892 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168865004893 active site 2 [active] 1168865004894 active site 1 [active] 1168865004895 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168865004896 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168865004897 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1168865004898 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1168865004899 putative NAD(P) binding site [chemical binding]; other site 1168865004900 active site 1168865004901 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1168865004902 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1168865004903 active site 1168865004904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168865004905 Histidine kinase; Region: HisKA_3; pfam07730 1168865004906 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168865004907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168865004908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865004909 active site 1168865004910 phosphorylation site [posttranslational modification] 1168865004911 intermolecular recognition site; other site 1168865004912 dimerization interface [polypeptide binding]; other site 1168865004913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168865004914 DNA binding residues [nucleotide binding] 1168865004915 dimerization interface [polypeptide binding]; other site 1168865004916 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1168865004917 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1168865004918 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1168865004919 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1168865004920 active site 1168865004921 dimerization interface [polypeptide binding]; other site 1168865004922 ribonuclease PH; Reviewed; Region: rph; PRK00173 1168865004923 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1168865004924 hexamer interface [polypeptide binding]; other site 1168865004925 active site 1168865004926 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1168865004927 glutamate racemase; Provisional; Region: PRK00865 1168865004928 Rhomboid family; Region: Rhomboid; pfam01694 1168865004929 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1168865004930 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1168865004931 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1168865004932 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1168865004933 active site 1168865004934 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1168865004935 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1168865004936 ATP binding site [chemical binding]; other site 1168865004937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168865004938 putative Mg++ binding site [ion binding]; other site 1168865004939 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1168865004940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168865004941 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168865004942 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1168865004943 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1168865004944 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1168865004945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865004946 motif II; other site 1168865004947 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 1168865004948 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1168865004949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168865004950 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1168865004951 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1168865004952 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1168865004953 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1168865004954 D-pathway; other site 1168865004955 Putative ubiquinol binding site [chemical binding]; other site 1168865004956 Low-spin heme (heme b) binding site [chemical binding]; other site 1168865004957 Putative water exit pathway; other site 1168865004958 Binuclear center (heme o3/CuB) [ion binding]; other site 1168865004959 K-pathway; other site 1168865004960 Putative proton exit pathway; other site 1168865004961 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1168865004962 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1168865004963 dimer interface [polypeptide binding]; other site 1168865004964 putative radical transfer pathway; other site 1168865004965 diiron center [ion binding]; other site 1168865004966 tyrosyl radical; other site 1168865004967 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1168865004968 Ferritin-like domain; Region: Ferritin; pfam00210 1168865004969 ferroxidase diiron center [ion binding]; other site 1168865004970 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1168865004971 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1168865004972 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1168865004973 active site 1168865004974 dimer interface [polypeptide binding]; other site 1168865004975 catalytic residues [active] 1168865004976 effector binding site; other site 1168865004977 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1168865004978 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1168865004979 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1168865004980 catalytic residues [active] 1168865004981 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1168865004982 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1168865004983 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1168865004984 homodimer interface [polypeptide binding]; other site 1168865004985 NAD binding pocket [chemical binding]; other site 1168865004986 ATP binding pocket [chemical binding]; other site 1168865004987 Mg binding site [ion binding]; other site 1168865004988 active-site loop [active] 1168865004989 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1168865004990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168865004991 dimerization interface [polypeptide binding]; other site 1168865004992 putative DNA binding site [nucleotide binding]; other site 1168865004993 putative Zn2+ binding site [ion binding]; other site 1168865004994 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1168865004995 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168865004996 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1168865004997 tRNA dimethylallyltransferase; Region: PLN02748 1168865004998 Thioredoxin; Region: Thioredoxin_4; cl17273 1168865004999 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1168865005000 phosphoglucomutase; Validated; Region: PRK07564 1168865005001 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1168865005002 active site 1168865005003 substrate binding site [chemical binding]; other site 1168865005004 metal binding site [ion binding]; metal-binding site 1168865005005 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 1168865005006 CrcB-like protein; Region: CRCB; pfam02537 1168865005007 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168865005008 FtsX-like permease family; Region: FtsX; pfam02687 1168865005009 FtsX-like permease family; Region: FtsX; pfam02687 1168865005010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168865005011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168865005012 Walker A/P-loop; other site 1168865005013 ATP binding site [chemical binding]; other site 1168865005014 Q-loop/lid; other site 1168865005015 ABC transporter signature motif; other site 1168865005016 Walker B; other site 1168865005017 D-loop; other site 1168865005018 H-loop/switch region; other site 1168865005019 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1168865005020 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1168865005021 hinge; other site 1168865005022 active site 1168865005023 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1168865005024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168865005025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168865005026 DNA binding residues [nucleotide binding] 1168865005027 dimerization interface [polypeptide binding]; other site 1168865005028 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168865005029 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168865005030 dimer interface [polypeptide binding]; other site 1168865005031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865005032 catalytic residue [active] 1168865005033 serine O-acetyltransferase; Region: cysE; TIGR01172 1168865005034 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1168865005035 trimer interface [polypeptide binding]; other site 1168865005036 active site 1168865005037 substrate binding site [chemical binding]; other site 1168865005038 CoA binding site [chemical binding]; other site 1168865005039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865005040 Coenzyme A binding pocket [chemical binding]; other site 1168865005041 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1168865005042 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1168865005043 putative active site [active] 1168865005044 metal binding site [ion binding]; metal-binding site 1168865005045 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1168865005046 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1168865005047 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1168865005048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168865005049 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1168865005050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865005051 Walker A/P-loop; other site 1168865005052 ATP binding site [chemical binding]; other site 1168865005053 Q-loop/lid; other site 1168865005054 ABC transporter signature motif; other site 1168865005055 Walker B; other site 1168865005056 D-loop; other site 1168865005057 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1168865005058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168865005059 Walker A/P-loop; other site 1168865005060 ATP binding site [chemical binding]; other site 1168865005061 Q-loop/lid; other site 1168865005062 ABC transporter signature motif; other site 1168865005063 Walker B; other site 1168865005064 D-loop; other site 1168865005065 H-loop/switch region; other site 1168865005066 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1168865005067 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1168865005068 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1168865005069 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1168865005070 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1168865005071 FMN binding site [chemical binding]; other site 1168865005072 active site 1168865005073 catalytic residues [active] 1168865005074 substrate binding site [chemical binding]; other site 1168865005075 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1168865005076 PhoU domain; Region: PhoU; pfam01895 1168865005077 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1168865005078 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1168865005079 Walker A/P-loop; other site 1168865005080 ATP binding site [chemical binding]; other site 1168865005081 Q-loop/lid; other site 1168865005082 ABC transporter signature motif; other site 1168865005083 Walker B; other site 1168865005084 D-loop; other site 1168865005085 H-loop/switch region; other site 1168865005086 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1168865005087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865005088 dimer interface [polypeptide binding]; other site 1168865005089 conserved gate region; other site 1168865005090 putative PBP binding loops; other site 1168865005091 ABC-ATPase subunit interface; other site 1168865005092 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1168865005093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865005094 dimer interface [polypeptide binding]; other site 1168865005095 conserved gate region; other site 1168865005096 putative PBP binding loops; other site 1168865005097 ABC-ATPase subunit interface; other site 1168865005098 PBP superfamily domain; Region: PBP_like_2; cl17296 1168865005099 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1168865005100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865005101 Coenzyme A binding pocket [chemical binding]; other site 1168865005102 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168865005103 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1168865005104 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1168865005105 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1168865005106 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1168865005107 heme-binding site [chemical binding]; other site 1168865005108 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1168865005109 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1168865005110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865005111 catalytic residue [active] 1168865005112 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1168865005113 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1168865005114 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1168865005115 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1168865005116 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1168865005117 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1168865005118 dimerization interface [polypeptide binding]; other site 1168865005119 putative ATP binding site [chemical binding]; other site 1168865005120 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1168865005121 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1168865005122 active site 1168865005123 tetramer interface [polypeptide binding]; other site 1168865005124 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865005125 active site 1168865005126 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1168865005127 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1168865005128 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1168865005129 dimer interface [polypeptide binding]; other site 1168865005130 putative radical transfer pathway; other site 1168865005131 diiron center [ion binding]; other site 1168865005132 tyrosyl radical; other site 1168865005133 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1168865005134 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1168865005135 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1168865005136 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1168865005137 dimerization interface [polypeptide binding]; other site 1168865005138 ATP binding site [chemical binding]; other site 1168865005139 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1168865005140 dimerization interface [polypeptide binding]; other site 1168865005141 ATP binding site [chemical binding]; other site 1168865005142 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1168865005143 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1168865005144 putative active site [active] 1168865005145 catalytic triad [active] 1168865005146 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1168865005147 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1168865005148 catalytic residues [active] 1168865005149 dimer interface [polypeptide binding]; other site 1168865005150 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1168865005151 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168865005152 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1168865005153 ATP binding site [chemical binding]; other site 1168865005154 active site 1168865005155 substrate binding site [chemical binding]; other site 1168865005156 adenylosuccinate lyase; Region: purB; TIGR00928 1168865005157 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1168865005158 tetramer interface [polypeptide binding]; other site 1168865005159 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1168865005160 TrkA-N domain; Region: TrkA_N; pfam02254 1168865005161 TrkA-C domain; Region: TrkA_C; pfam02080 1168865005162 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1168865005163 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1168865005164 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1168865005165 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1168865005166 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1168865005167 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1168865005168 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1168865005169 nucleotide binding site/active site [active] 1168865005170 HIT family signature motif; other site 1168865005171 catalytic residue [active] 1168865005172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168865005173 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168865005174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168865005175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168865005176 dimerization interface [polypeptide binding]; other site 1168865005177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168865005178 dimer interface [polypeptide binding]; other site 1168865005179 phosphorylation site [posttranslational modification] 1168865005180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865005181 ATP binding site [chemical binding]; other site 1168865005182 Mg2+ binding site [ion binding]; other site 1168865005183 G-X-G motif; other site 1168865005184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168865005185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865005186 active site 1168865005187 phosphorylation site [posttranslational modification] 1168865005188 intermolecular recognition site; other site 1168865005189 dimerization interface [polypeptide binding]; other site 1168865005190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168865005191 DNA binding site [nucleotide binding] 1168865005192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005193 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1168865005194 putative substrate translocation pore; other site 1168865005195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865005196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865005197 Predicted esterase [General function prediction only]; Region: COG0627 1168865005198 S-formylglutathione hydrolase; Region: PLN02442 1168865005199 xanthine permease; Region: pbuX; TIGR03173 1168865005200 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1168865005201 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1168865005202 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168865005203 putative active site [active] 1168865005204 pyruvate dehydrogenase; Provisional; Region: PRK06546 1168865005205 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1168865005206 PYR/PP interface [polypeptide binding]; other site 1168865005207 tetramer interface [polypeptide binding]; other site 1168865005208 dimer interface [polypeptide binding]; other site 1168865005209 TPP binding site [chemical binding]; other site 1168865005210 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168865005211 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1168865005212 TPP-binding site [chemical binding]; other site 1168865005213 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1168865005214 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1168865005215 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1168865005216 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1168865005217 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1168865005218 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1168865005219 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1168865005220 active site 1168865005221 homotetramer interface [polypeptide binding]; other site 1168865005222 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1168865005223 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1168865005224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168865005225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168865005226 DNA binding site [nucleotide binding] 1168865005227 domain linker motif; other site 1168865005228 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1168865005229 putative dimerization interface [polypeptide binding]; other site 1168865005230 putative ligand binding site [chemical binding]; other site 1168865005231 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1168865005232 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168865005233 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1168865005234 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168865005235 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1168865005236 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168865005237 active site 1168865005238 HIGH motif; other site 1168865005239 nucleotide binding site [chemical binding]; other site 1168865005240 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1168865005241 KMSKS motif; other site 1168865005242 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1168865005243 tRNA binding surface [nucleotide binding]; other site 1168865005244 anticodon binding site; other site 1168865005245 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1168865005246 homotrimer interaction site [polypeptide binding]; other site 1168865005247 zinc binding site [ion binding]; other site 1168865005248 CDP-binding sites; other site 1168865005249 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1168865005250 substrate binding site; other site 1168865005251 dimer interface; other site 1168865005252 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1168865005253 DNA repair protein RadA; Provisional; Region: PRK11823 1168865005254 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168865005255 Walker A motif; other site 1168865005256 ATP binding site [chemical binding]; other site 1168865005257 Walker B motif; other site 1168865005258 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1168865005259 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1168865005260 active site clefts [active] 1168865005261 zinc binding site [ion binding]; other site 1168865005262 dimer interface [polypeptide binding]; other site 1168865005263 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168865005264 endonuclease III; Region: ENDO3c; smart00478 1168865005265 minor groove reading motif; other site 1168865005266 helix-hairpin-helix signature motif; other site 1168865005267 substrate binding pocket [chemical binding]; other site 1168865005268 active site 1168865005269 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1168865005270 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1168865005271 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1168865005272 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1168865005273 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1168865005274 Clp amino terminal domain; Region: Clp_N; pfam02861 1168865005275 Clp amino terminal domain; Region: Clp_N; pfam02861 1168865005276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865005277 Walker A motif; other site 1168865005278 ATP binding site [chemical binding]; other site 1168865005279 Walker B motif; other site 1168865005280 arginine finger; other site 1168865005281 UvrB/uvrC motif; Region: UVR; pfam02151 1168865005282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865005283 Walker A motif; other site 1168865005284 ATP binding site [chemical binding]; other site 1168865005285 Walker B motif; other site 1168865005286 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1168865005287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005288 putative substrate translocation pore; other site 1168865005289 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1168865005290 active site 1168865005291 tetramer interface [polypeptide binding]; other site 1168865005292 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1168865005293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168865005294 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1168865005295 CAAX protease self-immunity; Region: Abi; pfam02517 1168865005296 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1168865005297 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1168865005298 dimer interface [polypeptide binding]; other site 1168865005299 putative anticodon binding site; other site 1168865005300 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168865005301 motif 1; other site 1168865005302 dimer interface [polypeptide binding]; other site 1168865005303 active site 1168865005304 motif 2; other site 1168865005305 motif 3; other site 1168865005306 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1168865005307 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1168865005308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1168865005309 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1168865005310 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1168865005311 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168865005312 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168865005313 NAD(P) binding site [chemical binding]; other site 1168865005314 catalytic residues [active] 1168865005315 BCCT family transporter; Region: BCCT; cl00569 1168865005316 choline dehydrogenase; Validated; Region: PRK02106 1168865005317 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168865005318 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1168865005319 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168865005320 active site 1168865005321 nucleotide binding site [chemical binding]; other site 1168865005322 HIGH motif; other site 1168865005323 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168865005324 KMSKS motif; other site 1168865005325 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1168865005326 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1168865005327 catalytic center binding site [active] 1168865005328 ATP binding site [chemical binding]; other site 1168865005329 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1168865005330 homooctamer interface [polypeptide binding]; other site 1168865005331 active site 1168865005332 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1168865005333 dihydropteroate synthase; Region: DHPS; TIGR01496 1168865005334 substrate binding pocket [chemical binding]; other site 1168865005335 dimer interface [polypeptide binding]; other site 1168865005336 inhibitor binding site; inhibition site 1168865005337 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1168865005338 GTP cyclohydrolase I; Provisional; Region: PLN03044 1168865005339 homodecamer interface [polypeptide binding]; other site 1168865005340 active site 1168865005341 putative catalytic site residues [active] 1168865005342 zinc binding site [ion binding]; other site 1168865005343 GTP-CH-I/GFRP interaction surface; other site 1168865005344 FtsH Extracellular; Region: FtsH_ext; pfam06480 1168865005345 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1168865005346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865005347 Walker A motif; other site 1168865005348 ATP binding site [chemical binding]; other site 1168865005349 Walker B motif; other site 1168865005350 arginine finger; other site 1168865005351 Peptidase family M41; Region: Peptidase_M41; pfam01434 1168865005352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865005353 active site 1168865005354 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1168865005355 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1168865005356 Ligand Binding Site [chemical binding]; other site 1168865005357 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1168865005358 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1168865005359 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1168865005360 dimer interface [polypeptide binding]; other site 1168865005361 substrate binding site [chemical binding]; other site 1168865005362 metal binding sites [ion binding]; metal-binding site 1168865005363 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1168865005364 active site residue [active] 1168865005365 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1168865005366 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1168865005367 Secretory lipase; Region: LIP; pfam03583 1168865005368 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168865005369 MarR family; Region: MarR_2; pfam12802 1168865005370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168865005371 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168865005372 acyl-activating enzyme (AAE) consensus motif; other site 1168865005373 AMP binding site [chemical binding]; other site 1168865005374 active site 1168865005375 CoA binding site [chemical binding]; other site 1168865005376 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168865005377 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1168865005378 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168865005379 putative trimer interface [polypeptide binding]; other site 1168865005380 putative CoA binding site [chemical binding]; other site 1168865005381 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168865005382 putative trimer interface [polypeptide binding]; other site 1168865005383 putative CoA binding site [chemical binding]; other site 1168865005384 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1168865005385 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1168865005386 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1168865005387 ring oligomerisation interface [polypeptide binding]; other site 1168865005388 ATP/Mg binding site [chemical binding]; other site 1168865005389 stacking interactions; other site 1168865005390 hinge regions; other site 1168865005391 hypothetical protein; Provisional; Region: PRK07907 1168865005392 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1168865005393 active site 1168865005394 metal binding site [ion binding]; metal-binding site 1168865005395 dimer interface [polypeptide binding]; other site 1168865005396 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1168865005397 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168865005398 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1168865005399 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1168865005400 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1168865005401 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1168865005402 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1168865005403 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168865005404 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1168865005405 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1168865005406 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1168865005407 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1168865005408 carboxylate-amine ligase; Provisional; Region: PRK13517 1168865005409 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1168865005410 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168865005411 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1168865005412 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1168865005413 active site 1168865005414 catalytic residues [active] 1168865005415 metal binding site [ion binding]; metal-binding site 1168865005416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168865005417 Coenzyme A binding pocket [chemical binding]; other site 1168865005418 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1168865005419 putative catalytic site [active] 1168865005420 putative phosphate binding site [ion binding]; other site 1168865005421 active site 1168865005422 metal binding site A [ion binding]; metal-binding site 1168865005423 DNA binding site [nucleotide binding] 1168865005424 putative AP binding site [nucleotide binding]; other site 1168865005425 putative metal binding site B [ion binding]; other site 1168865005426 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1168865005427 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1168865005428 putative active site [active] 1168865005429 catalytic site [active] 1168865005430 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1168865005431 putative active site [active] 1168865005432 catalytic site [active] 1168865005433 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1168865005434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168865005435 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1168865005436 Walker A/P-loop; other site 1168865005437 ATP binding site [chemical binding]; other site 1168865005438 Q-loop/lid; other site 1168865005439 ABC transporter signature motif; other site 1168865005440 Walker B; other site 1168865005441 D-loop; other site 1168865005442 H-loop/switch region; other site 1168865005443 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1168865005444 nudix motif; other site 1168865005445 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1168865005446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168865005447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168865005448 substrate binding pocket [chemical binding]; other site 1168865005449 membrane-bound complex binding site; other site 1168865005450 hinge residues; other site 1168865005451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168865005452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168865005453 active site 1168865005454 ATP binding site [chemical binding]; other site 1168865005455 substrate binding site [chemical binding]; other site 1168865005456 activation loop (A-loop); other site 1168865005457 propionate/acetate kinase; Provisional; Region: PRK12379 1168865005458 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1168865005459 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1168865005460 ferredoxin-NADP+ reductase; Region: PLN02852 1168865005461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168865005462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168865005463 Coenzyme A binding pocket [chemical binding]; other site 1168865005464 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1168865005465 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168865005466 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1168865005467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865005468 active site 1168865005469 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1168865005470 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1168865005471 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168865005472 catalytic residues [active] 1168865005473 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1168865005474 ResB-like family; Region: ResB; pfam05140 1168865005475 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1168865005476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1168865005477 TPR motif; other site 1168865005478 TPR repeat; Region: TPR_11; pfam13414 1168865005479 binding surface 1168865005480 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1168865005481 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1168865005482 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1168865005483 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1168865005484 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1168865005485 GDP-binding site [chemical binding]; other site 1168865005486 ACT binding site; other site 1168865005487 IMP binding site; other site 1168865005488 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1168865005489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168865005490 Walker A/P-loop; other site 1168865005491 ATP binding site [chemical binding]; other site 1168865005492 Q-loop/lid; other site 1168865005493 ABC transporter signature motif; other site 1168865005494 Walker B; other site 1168865005495 D-loop; other site 1168865005496 H-loop/switch region; other site 1168865005497 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168865005498 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1168865005499 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1168865005500 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1168865005501 active site 1168865005502 intersubunit interface [polypeptide binding]; other site 1168865005503 zinc binding site [ion binding]; other site 1168865005504 Na+ binding site [ion binding]; other site 1168865005505 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1168865005506 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168865005507 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168865005508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168865005509 active site 1168865005510 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1168865005511 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1168865005512 active site residue [active] 1168865005513 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1168865005514 active site residue [active] 1168865005515 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1168865005516 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1168865005517 active site 1168865005518 catalytic site [active] 1168865005519 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1168865005520 active site 1168865005521 catalytic site [active] 1168865005522 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1168865005523 Clp amino terminal domain; Region: Clp_N; pfam02861 1168865005524 Clp amino terminal domain; Region: Clp_N; pfam02861 1168865005525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865005526 Walker A motif; other site 1168865005527 ATP binding site [chemical binding]; other site 1168865005528 Walker B motif; other site 1168865005529 arginine finger; other site 1168865005530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168865005531 Walker A motif; other site 1168865005532 ATP binding site [chemical binding]; other site 1168865005533 Walker B motif; other site 1168865005534 arginine finger; other site 1168865005535 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1168865005536 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1168865005537 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168865005538 Walker A/P-loop; other site 1168865005539 ATP binding site [chemical binding]; other site 1168865005540 Q-loop/lid; other site 1168865005541 ABC transporter signature motif; other site 1168865005542 Walker B; other site 1168865005543 D-loop; other site 1168865005544 H-loop/switch region; other site 1168865005545 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1168865005546 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1168865005547 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1168865005548 FAD binding pocket [chemical binding]; other site 1168865005549 conserved FAD binding motif [chemical binding]; other site 1168865005550 phosphate binding motif [ion binding]; other site 1168865005551 beta-alpha-beta structure motif; other site 1168865005552 NAD binding pocket [chemical binding]; other site 1168865005553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168865005554 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1168865005555 FtsX-like permease family; Region: FtsX; pfam02687 1168865005556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168865005557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168865005558 Walker A/P-loop; other site 1168865005559 ATP binding site [chemical binding]; other site 1168865005560 Q-loop/lid; other site 1168865005561 ABC transporter signature motif; other site 1168865005562 Walker B; other site 1168865005563 D-loop; other site 1168865005564 H-loop/switch region; other site 1168865005565 HlyD family secretion protein; Region: HlyD_3; pfam13437 1168865005566 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1168865005567 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1168865005568 putative active site [active] 1168865005569 catalytic triad [active] 1168865005570 putative dimer interface [polypeptide binding]; other site 1168865005571 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1168865005572 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1168865005573 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1168865005574 NAD binding site [chemical binding]; other site 1168865005575 substrate binding site [chemical binding]; other site 1168865005576 catalytic Zn binding site [ion binding]; other site 1168865005577 tetramer interface [polypeptide binding]; other site 1168865005578 structural Zn binding site [ion binding]; other site 1168865005579 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168865005580 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168865005581 NAD(P) binding site [chemical binding]; other site 1168865005582 catalytic residues [active] 1168865005583 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1168865005584 active site 1168865005585 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1168865005586 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1168865005587 DNA binding residues [nucleotide binding] 1168865005588 chaperone protein DnaJ; Provisional; Region: PRK14279 1168865005589 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1168865005590 HSP70 interaction site [polypeptide binding]; other site 1168865005591 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1168865005592 Zn binding sites [ion binding]; other site 1168865005593 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1168865005594 dimer interface [polypeptide binding]; other site 1168865005595 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1168865005596 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1168865005597 dimer interface [polypeptide binding]; other site 1168865005598 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1168865005599 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1168865005600 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1168865005601 nucleotide binding site [chemical binding]; other site 1168865005602 NEF interaction site [polypeptide binding]; other site 1168865005603 SBD interface [polypeptide binding]; other site 1168865005604 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1168865005605 metal ion-dependent adhesion site (MIDAS); other site 1168865005606 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1168865005607 active site 1168865005608 catalytic site [active] 1168865005609 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1168865005610 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1168865005611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865005612 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1168865005613 Walker A/P-loop; other site 1168865005614 ATP binding site [chemical binding]; other site 1168865005615 Q-loop/lid; other site 1168865005616 ABC transporter signature motif; other site 1168865005617 Walker B; other site 1168865005618 D-loop; other site 1168865005619 H-loop/switch region; other site 1168865005620 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168865005621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865005622 dimer interface [polypeptide binding]; other site 1168865005623 conserved gate region; other site 1168865005624 putative PBP binding loops; other site 1168865005625 ABC-ATPase subunit interface; other site 1168865005626 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1168865005627 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865005628 Walker A/P-loop; other site 1168865005629 ATP binding site [chemical binding]; other site 1168865005630 Q-loop/lid; other site 1168865005631 ABC transporter signature motif; other site 1168865005632 Walker B; other site 1168865005633 D-loop; other site 1168865005634 H-loop/switch region; other site 1168865005635 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865005636 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865005637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865005638 dimer interface [polypeptide binding]; other site 1168865005639 conserved gate region; other site 1168865005640 putative PBP binding loops; other site 1168865005641 ABC-ATPase subunit interface; other site 1168865005642 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168865005643 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1168865005644 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1168865005645 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1168865005646 adrenodoxin reductase; Provisional; Region: PTZ00188 1168865005647 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1168865005648 4Fe-4S binding domain; Region: Fer4; cl02805 1168865005649 4Fe-4S binding domain; Region: Fer4; pfam00037 1168865005650 Cysteine-rich domain; Region: CCG; pfam02754 1168865005651 Cysteine-rich domain; Region: CCG; pfam02754 1168865005652 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1168865005653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168865005654 dimerization interface [polypeptide binding]; other site 1168865005655 putative DNA binding site [nucleotide binding]; other site 1168865005656 putative Zn2+ binding site [ion binding]; other site 1168865005657 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1168865005658 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865005659 Walker A/P-loop; other site 1168865005660 ATP binding site [chemical binding]; other site 1168865005661 Q-loop/lid; other site 1168865005662 ABC transporter signature motif; other site 1168865005663 Walker B; other site 1168865005664 D-loop; other site 1168865005665 H-loop/switch region; other site 1168865005666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1168865005667 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865005668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865005669 putative PBP binding regions; other site 1168865005670 ABC-ATPase subunit interface; other site 1168865005671 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1168865005672 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168865005673 intersubunit interface [polypeptide binding]; other site 1168865005674 UreD urease accessory protein; Region: UreD; cl00530 1168865005675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168865005676 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1168865005677 UreF; Region: UreF; pfam01730 1168865005678 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1168865005679 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1168865005680 dimer interface [polypeptide binding]; other site 1168865005681 catalytic residues [active] 1168865005682 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1168865005683 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1168865005684 subunit interactions [polypeptide binding]; other site 1168865005685 active site 1168865005686 flap region; other site 1168865005687 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1168865005688 gamma-beta subunit interface [polypeptide binding]; other site 1168865005689 alpha-beta subunit interface [polypeptide binding]; other site 1168865005690 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1168865005691 alpha-gamma subunit interface [polypeptide binding]; other site 1168865005692 beta-gamma subunit interface [polypeptide binding]; other site 1168865005693 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1168865005694 EamA-like transporter family; Region: EamA; pfam00892 1168865005695 EamA-like transporter family; Region: EamA; pfam00892 1168865005696 aminotransferase AlaT; Validated; Region: PRK09265 1168865005697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168865005698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865005699 homodimer interface [polypeptide binding]; other site 1168865005700 catalytic residue [active] 1168865005701 YibE/F-like protein; Region: YibE_F; pfam07907 1168865005702 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1168865005703 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1168865005704 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1168865005705 dimer interface [polypeptide binding]; other site 1168865005706 putative anticodon binding site; other site 1168865005707 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168865005708 motif 1; other site 1168865005709 dimer interface [polypeptide binding]; other site 1168865005710 active site 1168865005711 motif 2; other site 1168865005712 motif 3; other site 1168865005713 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1168865005714 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1168865005715 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1168865005716 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1168865005717 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1168865005718 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1168865005719 trimer interface [polypeptide binding]; other site 1168865005720 active site 1168865005721 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168865005722 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1168865005723 NAD(P) binding site [chemical binding]; other site 1168865005724 catalytic residues [active] 1168865005725 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1168865005726 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1168865005727 VanW like protein; Region: VanW; pfam04294 1168865005728 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1168865005729 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1168865005730 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1168865005731 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1168865005732 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1168865005733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168865005734 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168865005735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865005736 S-adenosylmethionine binding site [chemical binding]; other site 1168865005737 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1168865005738 active site 1168865005739 substrate-binding site [chemical binding]; other site 1168865005740 metal-binding site [ion binding] 1168865005741 GTP binding site [chemical binding]; other site 1168865005742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168865005743 S-adenosylmethionine binding site [chemical binding]; other site 1168865005744 LabA_like proteins; Region: LabA_like; cd06167 1168865005745 putative metal binding site [ion binding]; other site 1168865005746 MMPL family; Region: MMPL; pfam03176 1168865005747 MMPL family; Region: MMPL; pfam03176 1168865005748 Predicted integral membrane protein [Function unknown]; Region: COG0392 1168865005749 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1168865005750 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168865005751 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1168865005752 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168865005753 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168865005754 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1168865005755 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168865005756 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168865005757 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168865005758 active site 1168865005759 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168865005760 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1168865005761 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1168865005762 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168865005763 acyl-activating enzyme (AAE) consensus motif; other site 1168865005764 active site 1168865005765 Cutinase; Region: Cutinase; pfam01083 1168865005766 Putative esterase; Region: Esterase; pfam00756 1168865005767 S-formylglutathione hydrolase; Region: PLN02442 1168865005768 LGFP repeat; Region: LGFP; pfam08310 1168865005769 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1168865005770 LGFP repeat; Region: LGFP; pfam08310 1168865005771 LGFP repeat; Region: LGFP; pfam08310 1168865005772 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1168865005773 Predicted esterase [General function prediction only]; Region: COG0627 1168865005774 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1168865005775 UbiA prenyltransferase family; Region: UbiA; pfam01040 1168865005776 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1168865005777 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1168865005778 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168865005779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168865005780 Repair protein; Region: Repair_PSII; pfam04536 1168865005781 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1168865005782 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1168865005783 active site 1168865005784 catalytic site [active] 1168865005785 metal binding site [ion binding]; metal-binding site 1168865005786 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1168865005787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005788 putative substrate translocation pore; other site 1168865005789 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1168865005790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168865005791 UDP-galactopyranose mutase; Region: GLF; pfam03275 1168865005792 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1168865005793 ABC transporter; Region: ABC_tran; pfam00005 1168865005794 Q-loop/lid; other site 1168865005795 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168865005796 ABC transporter signature motif; other site 1168865005797 Walker B; other site 1168865005798 D-loop; other site 1168865005799 H-loop/switch region; other site 1168865005800 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1168865005801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168865005802 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1168865005803 putative PBP binding regions; other site 1168865005804 ABC-ATPase subunit interface; other site 1168865005805 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1168865005806 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1168865005807 putative binding site residues; other site 1168865005808 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1168865005809 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1168865005810 amidase catalytic site [active] 1168865005811 Zn binding residues [ion binding]; other site 1168865005812 substrate binding site [chemical binding]; other site 1168865005813 LGFP repeat; Region: LGFP; pfam08310 1168865005814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865005815 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1168865005816 active site 1168865005817 motif I; other site 1168865005818 motif II; other site 1168865005819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168865005820 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168865005821 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168865005822 putative acyl-acceptor binding pocket; other site 1168865005823 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1168865005824 seryl-tRNA synthetase; Provisional; Region: PRK05431 1168865005825 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1168865005826 dimer interface [polypeptide binding]; other site 1168865005827 active site 1168865005828 motif 1; other site 1168865005829 motif 2; other site 1168865005830 motif 3; other site 1168865005831 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1168865005832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168865005833 DNA-binding site [nucleotide binding]; DNA binding site 1168865005834 UTRA domain; Region: UTRA; pfam07702 1168865005835 Septum formation; Region: Septum_form; pfam13845 1168865005836 Septum formation; Region: Septum_form; pfam13845 1168865005837 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1168865005838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168865005839 catalytic core [active] 1168865005840 prephenate dehydratase; Provisional; Region: PRK11898 1168865005841 Prephenate dehydratase; Region: PDT; pfam00800 1168865005842 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1168865005843 putative L-Phe binding site [chemical binding]; other site 1168865005844 Amidase; Region: Amidase; cl11426 1168865005845 CAAX protease self-immunity; Region: Abi; pfam02517 1168865005846 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1168865005847 Htaa; Region: HtaA; pfam04213 1168865005848 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1168865005849 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1168865005850 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168865005851 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1168865005852 catalytic triad [active] 1168865005853 catalytic triad [active] 1168865005854 oxyanion hole [active] 1168865005855 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1168865005856 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1168865005857 putative active site [active] 1168865005858 catalytic site [active] 1168865005859 putative metal binding site [ion binding]; other site 1168865005860 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1168865005861 active site 1168865005862 catalytic motif [active] 1168865005863 Zn binding site [ion binding]; other site 1168865005864 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1168865005865 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1168865005866 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1168865005867 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1168865005868 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1168865005869 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1168865005870 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168865005871 NAD binding site [chemical binding]; other site 1168865005872 dimer interface [polypeptide binding]; other site 1168865005873 substrate binding site [chemical binding]; other site 1168865005874 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1168865005875 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1168865005876 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1168865005877 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1168865005878 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168865005879 Predicted flavoprotein [General function prediction only]; Region: COG0431 1168865005880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005881 putative substrate translocation pore; other site 1168865005882 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1168865005883 Abi-like protein; Region: Abi_2; pfam07751 1168865005884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005885 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1168865005886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005887 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1168865005888 homodimer interface [polypeptide binding]; other site 1168865005889 chemical substrate binding site [chemical binding]; other site 1168865005890 oligomer interface [polypeptide binding]; other site 1168865005891 metal binding site [ion binding]; metal-binding site 1168865005892 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1168865005893 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1168865005894 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1168865005895 Lsr2; Region: Lsr2; pfam11774 1168865005896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168865005897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865005898 active site 1168865005899 phosphorylation site [posttranslational modification] 1168865005900 intermolecular recognition site; other site 1168865005901 dimerization interface [polypeptide binding]; other site 1168865005902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168865005903 DNA binding residues [nucleotide binding] 1168865005904 dimerization interface [polypeptide binding]; other site 1168865005905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168865005906 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 1168865005907 Histidine kinase; Region: HisKA_3; pfam07730 1168865005908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168865005909 ATP binding site [chemical binding]; other site 1168865005910 Mg2+ binding site [ion binding]; other site 1168865005911 G-X-G motif; other site 1168865005912 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1168865005913 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1168865005914 active site 1168865005915 catalytic site [active] 1168865005916 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1168865005917 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1168865005918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168865005919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168865005920 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1168865005921 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168865005922 Ligand Binding Site [chemical binding]; other site 1168865005923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168865005924 Ligand Binding Site [chemical binding]; other site 1168865005925 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1168865005926 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1168865005927 active site 1168865005928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1168865005929 Predicted transcriptional regulators [Transcription]; Region: COG1725 1168865005930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168865005931 DNA-binding site [nucleotide binding]; DNA binding site 1168865005932 LabA_like proteins; Region: LabA_like; cd06167 1168865005933 putative metal binding site [ion binding]; other site 1168865005934 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1168865005935 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1168865005936 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1168865005937 catalytic residues [active] 1168865005938 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1168865005939 metal-binding site [ion binding] 1168865005940 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168865005941 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1168865005942 metal-binding site [ion binding] 1168865005943 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168865005944 benzoate transport; Region: 2A0115; TIGR00895 1168865005945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005946 putative substrate translocation pore; other site 1168865005947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168865005948 replicative DNA helicase; Provisional; Region: PRK05636 1168865005949 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1168865005950 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1168865005951 Walker A motif; other site 1168865005952 ATP binding site [chemical binding]; other site 1168865005953 Walker B motif; other site 1168865005954 DNA binding loops [nucleotide binding] 1168865005955 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1168865005956 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1168865005957 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1168865005958 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1168865005959 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1168865005960 dimer interface [polypeptide binding]; other site 1168865005961 ssDNA binding site [nucleotide binding]; other site 1168865005962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168865005963 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1168865005964 Predicted integral membrane protein [Function unknown]; Region: COG5650 1168865005965 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1168865005966 Transglycosylase; Region: Transgly; pfam00912 1168865005967 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1168865005968 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168865005969 MarR family; Region: MarR; pfam01047 1168865005970 MarR family; Region: MarR_2; cl17246 1168865005971 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168865005972 Ligand Binding Site [chemical binding]; other site 1168865005973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168865005974 Ligand Binding Site [chemical binding]; other site 1168865005975 short chain dehydrogenase; Provisional; Region: PRK08219 1168865005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168865005977 NAD(P) binding site [chemical binding]; other site 1168865005978 active site 1168865005979 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1168865005980 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1168865005981 active site residue [active] 1168865005982 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168865005983 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1168865005984 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1168865005985 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1168865005986 dimerization interface [polypeptide binding]; other site 1168865005987 DPS ferroxidase diiron center [ion binding]; other site 1168865005988 ion pore; other site 1168865005989 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1168865005990 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1168865005991 putative DNA binding site [nucleotide binding]; other site 1168865005992 catalytic residue [active] 1168865005993 putative H2TH interface [polypeptide binding]; other site 1168865005994 putative catalytic residues [active] 1168865005995 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168865005996 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168865005997 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1168865005998 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1168865005999 putative substrate binding site [chemical binding]; other site 1168865006000 putative ATP binding site [chemical binding]; other site 1168865006001 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1168865006002 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1168865006003 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1168865006004 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1168865006005 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1168865006006 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1168865006007 HIGH motif; other site 1168865006008 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1168865006009 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168865006010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168865006011 active site 1168865006012 KMSKS motif; other site 1168865006013 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1168865006014 tRNA binding surface [nucleotide binding]; other site 1168865006015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168865006016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168865006017 Walker A/P-loop; other site 1168865006018 ATP binding site [chemical binding]; other site 1168865006019 Q-loop/lid; other site 1168865006020 ABC transporter signature motif; other site 1168865006021 Walker B; other site 1168865006022 D-loop; other site 1168865006023 H-loop/switch region; other site 1168865006024 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168865006025 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1168865006026 FtsX-like permease family; Region: FtsX; pfam02687 1168865006027 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865006028 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865006029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168865006030 Histidine kinase; Region: HisKA_3; pfam07730 1168865006031 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168865006032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168865006033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168865006034 active site 1168865006035 phosphorylation site [posttranslational modification] 1168865006036 intermolecular recognition site; other site 1168865006037 dimerization interface [polypeptide binding]; other site 1168865006038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168865006039 DNA binding residues [nucleotide binding] 1168865006040 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865006041 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1168865006042 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865006043 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1168865006044 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1168865006045 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1168865006046 active site 1168865006047 trimer interface [polypeptide binding]; other site 1168865006048 allosteric site; other site 1168865006049 active site lid [active] 1168865006050 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1168865006051 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1168865006052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168865006053 active site 1168865006054 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1168865006055 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1168865006056 putative active site cavity [active] 1168865006057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168865006058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1168865006059 nucleotide binding site [chemical binding]; other site 1168865006060 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168865006061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168865006062 DNA-binding site [nucleotide binding]; DNA binding site 1168865006063 FCD domain; Region: FCD; pfam07729 1168865006064 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168865006065 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1168865006066 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168865006067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865006068 dimer interface [polypeptide binding]; other site 1168865006069 conserved gate region; other site 1168865006070 putative PBP binding loops; other site 1168865006071 ABC-ATPase subunit interface; other site 1168865006072 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168865006073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168865006074 dimer interface [polypeptide binding]; other site 1168865006075 conserved gate region; other site 1168865006076 putative PBP binding loops; other site 1168865006077 ABC-ATPase subunit interface; other site 1168865006078 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1168865006079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865006080 Walker A/P-loop; other site 1168865006081 ATP binding site [chemical binding]; other site 1168865006082 Q-loop/lid; other site 1168865006083 ABC transporter signature motif; other site 1168865006084 Walker B; other site 1168865006085 D-loop; other site 1168865006086 H-loop/switch region; other site 1168865006087 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1168865006088 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1168865006089 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168865006090 Walker A/P-loop; other site 1168865006091 ATP binding site [chemical binding]; other site 1168865006092 Q-loop/lid; other site 1168865006093 ABC transporter signature motif; other site 1168865006094 Walker B; other site 1168865006095 D-loop; other site 1168865006096 H-loop/switch region; other site 1168865006097 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168865006098 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1168865006099 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1168865006100 inhibitor site; inhibition site 1168865006101 active site 1168865006102 dimer interface [polypeptide binding]; other site 1168865006103 catalytic residue [active] 1168865006104 CAAX protease self-immunity; Region: Abi; pfam02517 1168865006105 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1168865006106 active site 1168865006107 catalytic residues [active] 1168865006108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1168865006109 hypothetical protein; Provisional; Region: PRK13663 1168865006110 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1168865006111 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1168865006112 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1168865006113 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1168865006114 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1168865006115 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1168865006116 substrate binding pocket [chemical binding]; other site 1168865006117 substrate-Mg2+ binding site; other site 1168865006118 aspartate-rich region 1; other site 1168865006119 aspartate-rich region 2; other site 1168865006120 phytoene desaturase; Region: crtI_fam; TIGR02734 1168865006121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168865006122 SdpI/YhfL protein family; Region: SdpI; pfam13630 1168865006123 anthranilate synthase component I; Provisional; Region: PRK13564 1168865006124 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1168865006125 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168865006126 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1168865006127 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1168865006128 glutamine binding [chemical binding]; other site 1168865006129 catalytic triad [active] 1168865006130 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1168865006131 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1168865006132 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1168865006133 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1168865006134 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1168865006135 active site 1168865006136 ribulose/triose binding site [chemical binding]; other site 1168865006137 phosphate binding site [ion binding]; other site 1168865006138 substrate (anthranilate) binding pocket [chemical binding]; other site 1168865006139 product (indole) binding pocket [chemical binding]; other site 1168865006140 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1168865006141 active site 1168865006142 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1168865006143 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1168865006144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168865006145 catalytic residue [active] 1168865006146 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1168865006147 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1168865006148 substrate binding site [chemical binding]; other site 1168865006149 active site 1168865006150 catalytic residues [active] 1168865006151 heterodimer interface [polypeptide binding]; other site 1168865006152 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1168865006153 iron-sulfur cluster [ion binding]; other site 1168865006154 [2Fe-2S] cluster binding site [ion binding]; other site 1168865006155 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1168865006156 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1168865006157 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1168865006158 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1168865006159 hypothetical protein; Validated; Region: PRK00228 1168865006160 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1168865006161 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1168865006162 active site 1168865006163 NTP binding site [chemical binding]; other site 1168865006164 metal binding triad [ion binding]; metal-binding site 1168865006165 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1168865006166 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168865006167 Zn2+ binding site [ion binding]; other site 1168865006168 Mg2+ binding site [ion binding]; other site 1168865006169 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1168865006170 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1168865006171 active site 1168865006172 Ap6A binding site [chemical binding]; other site 1168865006173 nudix motif; other site 1168865006174 metal binding site [ion binding]; metal-binding site 1168865006175 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1168865006176 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1168865006177 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1168865006178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168865006179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168865006180 DNA binding residues [nucleotide binding] 1168865006181 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1168865006182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168865006183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168865006184 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1168865006185 catalytic residues [active] 1168865006186 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1168865006187 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1168865006188 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1168865006189 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1168865006190 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1168865006191 active site 1168865006192 metal binding site [ion binding]; metal-binding site 1168865006193 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1168865006194 ParB-like nuclease domain; Region: ParBc; pfam02195 1168865006195 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168865006196 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168865006197 P-loop; other site 1168865006198 Magnesium ion binding site [ion binding]; other site 1168865006199 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168865006200 Magnesium ion binding site [ion binding]; other site 1168865006201 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1168865006202 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1168865006203 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1168865006204 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1168865006205 Ribosomal protein L34; Region: Ribosomal_L34; cl00370