-- dump date   	20140619_052230
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1074485000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
1074485000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485000003	Walker A motif; other site
1074485000004	ATP binding site [chemical binding]; other site
1074485000005	Walker B motif; other site
1074485000006	arginine finger; other site
1074485000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1074485000008	DnaA box-binding interface [nucleotide binding]; other site
1074485000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
1074485000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1074485000011	putative DNA binding surface [nucleotide binding]; other site
1074485000012	dimer interface [polypeptide binding]; other site
1074485000013	beta-clamp/clamp loader binding surface; other site
1074485000014	beta-clamp/translesion DNA polymerase binding surface; other site
1074485000015	recombination protein F; Reviewed; Region: recF; PRK00064
1074485000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1074485000017	Walker A/P-loop; other site
1074485000018	ATP binding site [chemical binding]; other site
1074485000019	Q-loop/lid; other site
1074485000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485000021	ABC transporter signature motif; other site
1074485000022	Walker B; other site
1074485000023	D-loop; other site
1074485000024	H-loop/switch region; other site
1074485000025	hypothetical protein; Provisional; Region: PRK00111
1074485000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1074485000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485000028	ATP binding site [chemical binding]; other site
1074485000029	Mg2+ binding site [ion binding]; other site
1074485000030	G-X-G motif; other site
1074485000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1074485000032	anchoring element; other site
1074485000033	dimer interface [polypeptide binding]; other site
1074485000034	ATP binding site [chemical binding]; other site
1074485000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1074485000036	active site
1074485000037	putative metal-binding site [ion binding]; other site
1074485000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1074485000039	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1074485000040	metal binding site [ion binding]; metal-binding site
1074485000041	DNA gyrase subunit A; Validated; Region: PRK05560
1074485000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1074485000043	CAP-like domain; other site
1074485000044	active site
1074485000045	primary dimer interface [polypeptide binding]; other site
1074485000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074485000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074485000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074485000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074485000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074485000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074485000052	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1074485000053	YwiC-like protein; Region: YwiC; pfam14256
1074485000054	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1074485000055	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1074485000056	putative ligand binding site [chemical binding]; other site
1074485000057	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1074485000058	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1074485000059	TM-ABC transporter signature motif; other site
1074485000060	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1074485000061	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1074485000062	Walker A/P-loop; other site
1074485000063	ATP binding site [chemical binding]; other site
1074485000064	Q-loop/lid; other site
1074485000065	ABC transporter signature motif; other site
1074485000066	Walker B; other site
1074485000067	D-loop; other site
1074485000068	H-loop/switch region; other site
1074485000069	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1074485000070	active site
1074485000071	Rhomboid family; Region: Rhomboid; pfam01694
1074485000072	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1074485000073	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
1074485000074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1074485000075	Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576
1074485000076	putative active site [active]
1074485000077	catalytic site [active]
1074485000078	Mg binding site [ion binding]; other site
1074485000079	catalytic loop [active]
1074485000080	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074485000081	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485000082	Walker A/P-loop; other site
1074485000083	ATP binding site [chemical binding]; other site
1074485000084	Q-loop/lid; other site
1074485000085	ABC transporter signature motif; other site
1074485000086	Walker B; other site
1074485000087	D-loop; other site
1074485000088	H-loop/switch region; other site
1074485000089	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074485000090	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485000091	ABC-ATPase subunit  interface; other site
1074485000092	dimer interface [polypeptide binding]; other site
1074485000093	putative PBP binding regions; other site
1074485000094	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485000095	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485000096	ABC-ATPase subunit  interface; other site
1074485000097	dimer interface [polypeptide binding]; other site
1074485000098	putative PBP binding regions; other site
1074485000099	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1074485000100	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074485000101	siderophore binding site; other site
1074485000102	putative septation inhibitor protein; Reviewed; Region: PRK00159
1074485000103	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1074485000104	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1074485000105	active site
1074485000106	ATP binding site [chemical binding]; other site
1074485000107	substrate binding site [chemical binding]; other site
1074485000108	activation loop (A-loop); other site
1074485000109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1074485000110	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485000111	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485000112	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485000113	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485000114	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1074485000115	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1074485000116	active site
1074485000117	ATP binding site [chemical binding]; other site
1074485000118	substrate binding site [chemical binding]; other site
1074485000119	activation loop (A-loop); other site
1074485000120	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074485000121	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074485000122	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1074485000123	Protein phosphatase 2C; Region: PP2C; pfam00481
1074485000124	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1074485000125	active site
1074485000126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1074485000127	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1074485000128	phosphopeptide binding site; other site
1074485000129	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1074485000130	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1074485000131	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1074485000132	phosphopeptide binding site; other site
1074485000133	CAAX protease self-immunity; Region: Abi; pfam02517
1074485000134	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1074485000135	Predicted transcriptional regulators [Transcription]; Region: COG1695
1074485000136	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1074485000137	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074485000138	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485000139	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1074485000140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1074485000141	Divalent cation transporter; Region: MgtE; pfam01769
1074485000142	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1074485000143	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348
1074485000144	active site
1074485000145	catalytic site [active]
1074485000146	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1074485000147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485000148	H+ Antiporter protein; Region: 2A0121; TIGR00900
1074485000149	putative substrate translocation pore; other site
1074485000150	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1074485000151	RNA polymerase sigma factor; Provisional; Region: PRK12537
1074485000152	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485000153	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485000154	DNA binding residues [nucleotide binding]
1074485000155	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1074485000156	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1074485000157	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1074485000158	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1074485000159	catalytic residues [active]
1074485000160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074485000161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485000162	dimer interface [polypeptide binding]; other site
1074485000163	conserved gate region; other site
1074485000164	putative PBP binding loops; other site
1074485000165	ABC-ATPase subunit interface; other site
1074485000166	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1074485000167	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485000168	Walker A/P-loop; other site
1074485000169	ATP binding site [chemical binding]; other site
1074485000170	Q-loop/lid; other site
1074485000171	ABC transporter signature motif; other site
1074485000172	Walker B; other site
1074485000173	D-loop; other site
1074485000174	H-loop/switch region; other site
1074485000175	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074485000176	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485000177	Coenzyme A binding pocket [chemical binding]; other site
1074485000178	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1074485000179	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1074485000180	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
1074485000181	putative metal binding site [ion binding]; other site
1074485000182	biotin synthase; Validated; Region: PRK06256
1074485000183	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485000184	FeS/SAM binding site; other site
1074485000185	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1074485000186	MepB protein; Region: MepB; cl01985
1074485000187	AMP nucleosidase; Provisional; Region: PRK08292
1074485000188	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1074485000189	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1074485000190	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1074485000191	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1074485000192	active site
1074485000193	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1074485000194	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1074485000195	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1074485000196	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1074485000197	Lipase (class 2); Region: Lipase_2; pfam01674
1074485000198	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
1074485000199	dimer interface [polypeptide binding]; other site
1074485000200	FMN binding site [chemical binding]; other site
1074485000201	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1074485000202	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1074485000203	trimer interface [polypeptide binding]; other site
1074485000204	putative metal binding site [ion binding]; other site
1074485000205	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1074485000206	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1074485000207	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1074485000208	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1074485000209	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074485000210	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485000211	Coenzyme A binding pocket [chemical binding]; other site
1074485000212	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1074485000213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
1074485000214	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1074485000215	MarR family; Region: MarR; pfam01047
1074485000216	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1074485000217	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1074485000218	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1074485000219	hypothetical protein; Provisional; Region: PRK10621
1074485000220	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074485000221	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074485000222	active site
1074485000223	phosphorylation site [posttranslational modification]
1074485000224	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1074485000225	active site
1074485000226	P-loop; other site
1074485000227	phosphorylation site [posttranslational modification]
1074485000228	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1074485000229	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
1074485000230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485000231	ATP binding site [chemical binding]; other site
1074485000232	putative Mg++ binding site [ion binding]; other site
1074485000233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485000234	nucleotide binding region [chemical binding]; other site
1074485000235	ATP-binding site [chemical binding]; other site
1074485000236	Helicase associated domain (HA2); Region: HA2; pfam04408
1074485000237	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1074485000238	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1074485000239	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1074485000240	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1074485000241	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485000242	NAD(P) binding site [chemical binding]; other site
1074485000243	active site
1074485000244	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1074485000245	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485000246	RNA binding surface [nucleotide binding]; other site
1074485000247	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1074485000248	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074485000249	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1074485000250	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1074485000251	DNA binding site [nucleotide binding]
1074485000252	active site
1074485000253	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1074485000254	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1074485000255	active site
1074485000256	glycerol kinase; Provisional; Region: glpK; PRK00047
1074485000257	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1074485000258	nucleotide binding site [chemical binding]; other site
1074485000259	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1074485000260	amphipathic channel; other site
1074485000261	Asn-Pro-Ala signature motifs; other site
1074485000262	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074485000263	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1074485000264	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1074485000265	active site
1074485000266	Zn binding site [ion binding]; other site
1074485000267	Protease prsW family; Region: PrsW-protease; pfam13367
1074485000268	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1074485000269	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1074485000270	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1074485000271	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1074485000272	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1074485000273	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1074485000274	classical (c) SDRs; Region: SDR_c; cd05233
1074485000275	NAD(P) binding site [chemical binding]; other site
1074485000276	active site
1074485000277	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1074485000278	FAD binding domain; Region: FAD_binding_4; pfam01565
1074485000279	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1074485000280	Predicted membrane protein [Function unknown]; Region: COG2246
1074485000281	GtrA-like protein; Region: GtrA; pfam04138
1074485000282	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1074485000283	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1074485000284	active site
1074485000285	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485000286	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1074485000287	intersubunit interface [polypeptide binding]; other site
1074485000288	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074485000289	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074485000290	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074485000291	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1074485000292	ABC-ATPase subunit  interface; other site
1074485000293	dimer interface [polypeptide binding]; other site
1074485000294	putative PBP binding regions; other site
1074485000295	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074485000296	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485000297	ABC-ATPase subunit  interface; other site
1074485000298	dimer interface [polypeptide binding]; other site
1074485000299	putative PBP binding regions; other site
1074485000300	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485000301	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1074485000302	intersubunit interface [polypeptide binding]; other site
1074485000303	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1074485000304	active site
1074485000305	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1074485000306	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1074485000307	Walker A/P-loop; other site
1074485000308	ATP binding site [chemical binding]; other site
1074485000309	Q-loop/lid; other site
1074485000310	ABC transporter signature motif; other site
1074485000311	Walker B; other site
1074485000312	D-loop; other site
1074485000313	H-loop/switch region; other site
1074485000314	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1074485000315	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1074485000316	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1074485000317	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074485000318	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1074485000319	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1074485000320	NAD(P) binding site [chemical binding]; other site
1074485000321	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1074485000322	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485000323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485000324	homodimer interface [polypeptide binding]; other site
1074485000325	catalytic residue [active]
1074485000326	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1074485000327	transmembrane helices; other site
1074485000328	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074485000329	CAT RNA binding domain; Region: CAT_RBD; smart01061
1074485000330	PRD domain; Region: PRD; pfam00874
1074485000331	PRD domain; Region: PRD; pfam00874
1074485000332	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1074485000333	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074485000334	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074485000335	active site turn [active]
1074485000336	phosphorylation site [posttranslational modification]
1074485000337	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1074485000338	HPr interaction site; other site
1074485000339	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074485000340	active site
1074485000341	phosphorylation site [posttranslational modification]
1074485000342	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1074485000343	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074485000344	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1074485000345	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074485000346	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
1074485000347	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1074485000348	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074485000349	DNA-binding site [nucleotide binding]; DNA binding site
1074485000350	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485000351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485000352	homodimer interface [polypeptide binding]; other site
1074485000353	catalytic residue [active]
1074485000354	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1074485000355	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1074485000356	active site
1074485000357	multimer interface [polypeptide binding]; other site
1074485000358	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1074485000359	predicted active site [active]
1074485000360	catalytic triad [active]
1074485000361	prephenate dehydrogenase; Validated; Region: PRK06545
1074485000362	prephenate dehydrogenase; Validated; Region: PRK08507
1074485000363	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1074485000364	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1074485000365	nucleoside/Zn binding site; other site
1074485000366	dimer interface [polypeptide binding]; other site
1074485000367	catalytic motif [active]
1074485000368	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1074485000369	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1074485000370	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1074485000371	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1074485000372	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
1074485000373	active site
1074485000374	KMSKS motif; other site
1074485000375	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1074485000376	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1074485000377	Shikimate kinase; Region: SKI; pfam01202
1074485000378	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1074485000379	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1074485000380	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1074485000381	putative NAD(P) binding site [chemical binding]; other site
1074485000382	catalytic Zn binding site [ion binding]; other site
1074485000383	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
1074485000384	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1074485000385	NADP binding site [chemical binding]; other site
1074485000386	homodimer interface [polypeptide binding]; other site
1074485000387	active site
1074485000388	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1074485000389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485000390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485000391	homodimer interface [polypeptide binding]; other site
1074485000392	catalytic residue [active]
1074485000393	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1074485000394	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1074485000395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485000396	Walker A motif; other site
1074485000397	ATP binding site [chemical binding]; other site
1074485000398	Walker B motif; other site
1074485000399	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074485000400	arginine finger; other site
1074485000401	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1074485000402	hypothetical protein; Validated; Region: PRK00153
1074485000403	recombination protein RecR; Reviewed; Region: recR; PRK00076
1074485000404	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
1074485000405	RecR protein; Region: RecR; pfam02132
1074485000406	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1074485000407	putative active site [active]
1074485000408	putative metal-binding site [ion binding]; other site
1074485000409	tetramer interface [polypeptide binding]; other site
1074485000410	putative transporter; Provisional; Region: PRK09821
1074485000411	GntP family permease; Region: GntP_permease; pfam02447
1074485000412	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1074485000413	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1074485000414	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1074485000415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1074485000416	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1074485000417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074485000418	DNA-binding site [nucleotide binding]; DNA binding site
1074485000419	FCD domain; Region: FCD; pfam07729
1074485000420	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1074485000421	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1074485000422	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1074485000423	catalytic triad [active]
1074485000424	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1074485000425	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485000426	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1074485000427	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
1074485000428	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1074485000429	active site
1074485000430	catalytic site [active]
1074485000431	substrate binding site [chemical binding]; other site
1074485000432	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
1074485000433	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1074485000434	dimer interface [polypeptide binding]; other site
1074485000435	FMN binding site [chemical binding]; other site
1074485000436	NADPH bind site [chemical binding]; other site
1074485000437	2-isopropylmalate synthase; Validated; Region: PRK03739
1074485000438	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1074485000439	active site
1074485000440	catalytic residues [active]
1074485000441	metal binding site [ion binding]; metal-binding site
1074485000442	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1074485000443	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1074485000444	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485000445	DNA binding residues [nucleotide binding]
1074485000446	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1074485000447	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1074485000448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485000449	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074485000450	putative substrate translocation pore; other site
1074485000451	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1074485000452	intersubunit interface [polypeptide binding]; other site
1074485000453	active site
1074485000454	catalytic residue [active]
1074485000455	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1074485000456	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1074485000457	active site
1074485000458	substrate binding site [chemical binding]; other site
1074485000459	metal binding site [ion binding]; metal-binding site
1074485000460	TQXA domain; Region: TQXA_dom; TIGR03934
1074485000461	Cna protein B-type domain; Region: Cna_B; pfam05738
1074485000462	Cna protein B-type domain; Region: Cna_B; pfam05738
1074485000463	Cna protein B-type domain; Region: Cna_B; pfam05738
1074485000464	aspartate kinase; Reviewed; Region: PRK06635
1074485000465	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1074485000466	putative nucleotide binding site [chemical binding]; other site
1074485000467	putative catalytic residues [active]
1074485000468	putative Mg ion binding site [ion binding]; other site
1074485000469	putative aspartate binding site [chemical binding]; other site
1074485000470	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1074485000471	putative allosteric regulatory site; other site
1074485000472	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1074485000473	putative allosteric regulatory residue; other site
1074485000474	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1074485000475	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1074485000476	RNA polymerase sigma factor; Provisional; Region: PRK12535
1074485000477	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485000478	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1074485000479	DNA binding residues [nucleotide binding]
1074485000480	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1074485000481	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1074485000482	heme binding pocket [chemical binding]; other site
1074485000483	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1074485000484	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1074485000485	Walker A/P-loop; other site
1074485000486	ATP binding site [chemical binding]; other site
1074485000487	Q-loop/lid; other site
1074485000488	ABC transporter signature motif; other site
1074485000489	Walker B; other site
1074485000490	D-loop; other site
1074485000491	H-loop/switch region; other site
1074485000492	TOBE domain; Region: TOBE_2; pfam08402
1074485000493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485000494	dimer interface [polypeptide binding]; other site
1074485000495	conserved gate region; other site
1074485000496	ABC-ATPase subunit interface; other site
1074485000497	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1074485000498	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1074485000499	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1074485000500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485000501	putative substrate translocation pore; other site
1074485000502	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074485000503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485000504	active site
1074485000505	phosphorylation site [posttranslational modification]
1074485000506	intermolecular recognition site; other site
1074485000507	dimerization interface [polypeptide binding]; other site
1074485000508	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074485000509	DNA binding site [nucleotide binding]
1074485000510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074485000511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074485000512	dimer interface [polypeptide binding]; other site
1074485000513	phosphorylation site [posttranslational modification]
1074485000514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485000515	ATP binding site [chemical binding]; other site
1074485000516	Mg2+ binding site [ion binding]; other site
1074485000517	G-X-G motif; other site
1074485000518	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1074485000519	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
1074485000520	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
1074485000521	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
1074485000522	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074485000523	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
1074485000524	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
1074485000525	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074485000526	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1074485000527	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1074485000528	Predicted membrane protein [Function unknown]; Region: COG1511
1074485000529	Predicted membrane protein [Function unknown]; Region: COG1511
1074485000530	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1074485000531	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1074485000532	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1074485000533	putative active site [active]
1074485000534	putative metal binding site [ion binding]; other site
1074485000535	Yqey-like protein; Region: YqeY; pfam09424
1074485000536	Transglycosylase; Region: Transgly; pfam00912
1074485000537	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1074485000538	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1074485000539	PASTA domain; Region: PASTA; pfam03793
1074485000540	Transcription factor WhiB; Region: Whib; pfam02467
1074485000541	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1074485000542	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1074485000543	homotrimer interaction site [polypeptide binding]; other site
1074485000544	putative active site [active]
1074485000545	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074485000546	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1074485000547	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1074485000548	ligand binding site [chemical binding]; other site
1074485000549	flexible hinge region; other site
1074485000550	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1074485000551	putative switch regulator; other site
1074485000552	non-specific DNA interactions [nucleotide binding]; other site
1074485000553	DNA binding site [nucleotide binding]
1074485000554	sequence specific DNA binding site [nucleotide binding]; other site
1074485000555	putative cAMP binding site [chemical binding]; other site
1074485000556	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1074485000557	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074485000558	minor groove reading motif; other site
1074485000559	helix-hairpin-helix signature motif; other site
1074485000560	substrate binding pocket [chemical binding]; other site
1074485000561	active site
1074485000562	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1074485000563	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1074485000564	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1074485000565	catalytic residues [active]
1074485000566	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1074485000567	putative active site [active]
1074485000568	putative CoA binding site [chemical binding]; other site
1074485000569	nudix motif; other site
1074485000570	metal binding site [ion binding]; metal-binding site
1074485000571	Colicin V production protein; Region: Colicin_V; pfam02674
1074485000572	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1074485000573	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1074485000574	active site
1074485000575	substrate binding sites [chemical binding]; other site
1074485000576	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1074485000577	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074485000578	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1074485000579	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485000580	motif II; other site
1074485000581	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1074485000582	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1074485000583	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1074485000584	ATP binding site [chemical binding]; other site
1074485000585	Walker A motif; other site
1074485000586	hexamer interface [polypeptide binding]; other site
1074485000587	Walker B motif; other site
1074485000588	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1074485000589	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1074485000590	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
1074485000591	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1074485000592	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485000593	ATP binding site [chemical binding]; other site
1074485000594	putative Mg++ binding site [ion binding]; other site
1074485000595	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485000596	nucleotide binding region [chemical binding]; other site
1074485000597	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1074485000598	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1074485000599	DNA-binding site [nucleotide binding]; DNA binding site
1074485000600	RNA-binding motif; other site
1074485000601	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1074485000602	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1074485000603	active site
1074485000604	interdomain interaction site; other site
1074485000605	putative metal-binding site [ion binding]; other site
1074485000606	nucleotide binding site [chemical binding]; other site
1074485000607	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1074485000608	domain I; other site
1074485000609	DNA binding groove [nucleotide binding]
1074485000610	phosphate binding site [ion binding]; other site
1074485000611	domain II; other site
1074485000612	domain III; other site
1074485000613	nucleotide binding site [chemical binding]; other site
1074485000614	catalytic site [active]
1074485000615	domain IV; other site
1074485000616	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1074485000617	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1074485000618	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1074485000619	Predicted membrane protein [Function unknown]; Region: COG1297
1074485000620	putative oligopeptide transporter, OPT family; Region: TIGR00733
1074485000621	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074485000622	dimerization interface [polypeptide binding]; other site
1074485000623	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1074485000624	cyclase homology domain; Region: CHD; cd07302
1074485000625	nucleotidyl binding site; other site
1074485000626	metal binding site [ion binding]; metal-binding site
1074485000627	dimer interface [polypeptide binding]; other site
1074485000628	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1074485000629	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1074485000630	acyl-CoA synthetase; Validated; Region: PRK07788
1074485000631	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485000632	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485000633	acyl-activating enzyme (AAE) consensus motif; other site
1074485000634	acyl-activating enzyme (AAE) consensus motif; other site
1074485000635	AMP binding site [chemical binding]; other site
1074485000636	active site
1074485000637	CoA binding site [chemical binding]; other site
1074485000638	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1074485000639	active site
1074485000640	catalytic triad [active]
1074485000641	oxyanion hole [active]
1074485000642	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1074485000643	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1074485000644	substrate binding site; other site
1074485000645	tetramer interface; other site
1074485000646	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1074485000647	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1074485000648	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1074485000649	NADP binding site [chemical binding]; other site
1074485000650	active site
1074485000651	putative substrate binding site [chemical binding]; other site
1074485000652	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1074485000653	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1074485000654	NAD binding site [chemical binding]; other site
1074485000655	substrate binding site [chemical binding]; other site
1074485000656	homodimer interface [polypeptide binding]; other site
1074485000657	active site
1074485000658	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1074485000659	Zn binding site [ion binding]; other site
1074485000660	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1074485000661	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1074485000662	Putative esterase; Region: Esterase; pfam00756
1074485000663	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1074485000664	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1074485000665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074485000666	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074485000667	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074485000668	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074485000669	non-specific DNA binding site [nucleotide binding]; other site
1074485000670	salt bridge; other site
1074485000671	sequence-specific DNA binding site [nucleotide binding]; other site
1074485000672	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1074485000673	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1074485000674	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1074485000675	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
1074485000676	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1074485000677	putative Iron-sulfur protein interface [polypeptide binding]; other site
1074485000678	proximal heme binding site [chemical binding]; other site
1074485000679	distal heme binding site [chemical binding]; other site
1074485000680	putative dimer interface [polypeptide binding]; other site
1074485000681	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
1074485000682	L-aspartate oxidase; Provisional; Region: PRK06175
1074485000683	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1074485000684	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
1074485000685	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1074485000686	Predicted membrane protein [Function unknown]; Region: COG2733
1074485000687	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1074485000688	Class I aldolases; Region: Aldolase_Class_I; cl17187
1074485000689	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1074485000690	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1074485000691	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485000692	FeS/SAM binding site; other site
1074485000693	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1074485000694	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1074485000695	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1074485000696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1074485000697	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1074485000698	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1074485000699	FAD binding domain; Region: FAD_binding_4; pfam01565
1074485000700	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1074485000701	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
1074485000702	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1074485000703	acyl-activating enzyme (AAE) consensus motif; other site
1074485000704	putative AMP binding site [chemical binding]; other site
1074485000705	putative active site [active]
1074485000706	putative CoA binding site [chemical binding]; other site
1074485000707	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1074485000708	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1074485000709	putative ADP-binding pocket [chemical binding]; other site
1074485000710	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485000711	catalytic core [active]
1074485000712	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485000713	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1074485000714	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074485000715	dimer interface [polypeptide binding]; other site
1074485000716	phosphorylation site [posttranslational modification]
1074485000717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485000718	ATP binding site [chemical binding]; other site
1074485000719	Mg2+ binding site [ion binding]; other site
1074485000720	G-X-G motif; other site
1074485000721	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074485000722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485000723	active site
1074485000724	phosphorylation site [posttranslational modification]
1074485000725	intermolecular recognition site; other site
1074485000726	dimerization interface [polypeptide binding]; other site
1074485000727	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074485000728	DNA binding site [nucleotide binding]
1074485000729	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1074485000730	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1074485000731	DNA binding domain, excisionase family; Region: excise; TIGR01764
1074485000732	Thioredoxin; Region: Thioredoxin_4; cl17273
1074485000733	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1074485000734	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1074485000735	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1074485000736	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1074485000737	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1074485000738	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1074485000739	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1074485000740	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1074485000741	tRNA; other site
1074485000742	putative tRNA binding site [nucleotide binding]; other site
1074485000743	putative NADP binding site [chemical binding]; other site
1074485000744	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1074485000745	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1074485000746	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1074485000747	domain interfaces; other site
1074485000748	active site
1074485000749	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1074485000750	active site
1074485000751	homodimer interface [polypeptide binding]; other site
1074485000752	SAM binding site [chemical binding]; other site
1074485000753	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1074485000754	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1074485000755	active site
1074485000756	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1074485000757	dimer interface [polypeptide binding]; other site
1074485000758	active site
1074485000759	Schiff base residues; other site
1074485000760	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074485000761	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1074485000762	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1074485000763	substrate binding site [chemical binding]; other site
1074485000764	active site
1074485000765	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1074485000766	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1074485000767	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1074485000768	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1074485000769	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074485000770	inhibitor-cofactor binding pocket; inhibition site
1074485000771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485000772	catalytic residue [active]
1074485000773	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485000774	catalytic core [active]
1074485000775	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1074485000776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1074485000777	catalytic residues [active]
1074485000778	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1074485000779	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1074485000780	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1074485000781	ResB-like family; Region: ResB; pfam05140
1074485000782	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074485000783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485000784	S-adenosylmethionine binding site [chemical binding]; other site
1074485000785	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074485000786	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485000787	Walker A/P-loop; other site
1074485000788	ATP binding site [chemical binding]; other site
1074485000789	Q-loop/lid; other site
1074485000790	ABC transporter signature motif; other site
1074485000791	Walker B; other site
1074485000792	D-loop; other site
1074485000793	H-loop/switch region; other site
1074485000794	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074485000795	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485000796	intersubunit interface [polypeptide binding]; other site
1074485000797	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074485000798	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485000799	ABC-ATPase subunit  interface; other site
1074485000800	dimer interface [polypeptide binding]; other site
1074485000801	putative PBP binding regions; other site
1074485000802	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1074485000803	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
1074485000804	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1074485000805	UbiA prenyltransferase family; Region: UbiA; pfam01040
1074485000806	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1074485000807	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485000808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485000809	acyl-activating enzyme (AAE) consensus motif; other site
1074485000810	acyl-activating enzyme (AAE) consensus motif; other site
1074485000811	AMP binding site [chemical binding]; other site
1074485000812	active site
1074485000813	CoA binding site [chemical binding]; other site
1074485000814	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1074485000815	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074485000816	substrate binding site [chemical binding]; other site
1074485000817	oxyanion hole (OAH) forming residues; other site
1074485000818	trimer interface [polypeptide binding]; other site
1074485000819	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1074485000820	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
1074485000821	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1074485000822	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1074485000823	active site
1074485000824	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1074485000825	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1074485000826	dimer interface [polypeptide binding]; other site
1074485000827	tetramer interface [polypeptide binding]; other site
1074485000828	PYR/PP interface [polypeptide binding]; other site
1074485000829	TPP binding site [chemical binding]; other site
1074485000830	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1074485000831	TPP-binding site; other site
1074485000832	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1074485000833	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1074485000834	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074485000835	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1074485000836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485000837	S-adenosylmethionine binding site [chemical binding]; other site
1074485000838	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1074485000839	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1074485000840	NAD(P) binding site [chemical binding]; other site
1074485000841	LDH/MDH dimer interface [polypeptide binding]; other site
1074485000842	substrate binding site [chemical binding]; other site
1074485000843	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1074485000844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074485000845	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1074485000846	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1074485000847	substrate binding pocket [chemical binding]; other site
1074485000848	chain length determination region; other site
1074485000849	substrate-Mg2+ binding site; other site
1074485000850	catalytic residues [active]
1074485000851	aspartate-rich region 1; other site
1074485000852	active site lid residues [active]
1074485000853	aspartate-rich region 2; other site
1074485000854	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1074485000855	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1074485000856	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1074485000857	putative homodimer interface [polypeptide binding]; other site
1074485000858	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1074485000859	heterodimer interface [polypeptide binding]; other site
1074485000860	homodimer interface [polypeptide binding]; other site
1074485000861	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1074485000862	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1074485000863	23S rRNA interface [nucleotide binding]; other site
1074485000864	L7/L12 interface [polypeptide binding]; other site
1074485000865	putative thiostrepton binding site; other site
1074485000866	L25 interface [polypeptide binding]; other site
1074485000867	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1074485000868	mRNA/rRNA interface [nucleotide binding]; other site
1074485000869	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1074485000870	trimer interface [polypeptide binding]; other site
1074485000871	active site
1074485000872	G bulge; other site
1074485000873	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1074485000874	trimer interface [polypeptide binding]; other site
1074485000875	active site
1074485000876	G bulge; other site
1074485000877	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1074485000878	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1074485000879	FMN binding site [chemical binding]; other site
1074485000880	active site
1074485000881	substrate binding site [chemical binding]; other site
1074485000882	catalytic residue [active]
1074485000883	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1074485000884	23S rRNA interface [nucleotide binding]; other site
1074485000885	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1074485000886	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1074485000887	L11 interface [polypeptide binding]; other site
1074485000888	putative EF-Tu interaction site [polypeptide binding]; other site
1074485000889	putative EF-G interaction site [polypeptide binding]; other site
1074485000890	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1074485000891	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
1074485000892	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485000893	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1074485000894	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485000895	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074485000896	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
1074485000897	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1074485000898	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074485000899	ABC-ATPase subunit  interface; other site
1074485000900	dimer interface [polypeptide binding]; other site
1074485000901	putative PBP binding regions; other site
1074485000902	Ethylene insensitive 3; Region: EIN3; cl04813
1074485000903	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1074485000904	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1074485000905	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1074485000906	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1074485000907	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1074485000908	RPB1 interaction site [polypeptide binding]; other site
1074485000909	RPB10 interaction site [polypeptide binding]; other site
1074485000910	RPB11 interaction site [polypeptide binding]; other site
1074485000911	RPB3 interaction site [polypeptide binding]; other site
1074485000912	RPB12 interaction site [polypeptide binding]; other site
1074485000913	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1074485000914	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1074485000915	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1074485000916	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1074485000917	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1074485000918	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1074485000919	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1074485000920	G-loop; other site
1074485000921	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1074485000922	DNA binding site [nucleotide binding]
1074485000923	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1074485000924	Histidine kinase; Region: HisKA_3; pfam07730
1074485000925	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074485000926	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074485000927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485000928	active site
1074485000929	phosphorylation site [posttranslational modification]
1074485000930	intermolecular recognition site; other site
1074485000931	dimerization interface [polypeptide binding]; other site
1074485000932	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074485000933	DNA binding residues [nucleotide binding]
1074485000934	dimerization interface [polypeptide binding]; other site
1074485000935	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074485000936	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1074485000937	Walker A/P-loop; other site
1074485000938	ATP binding site [chemical binding]; other site
1074485000939	Q-loop/lid; other site
1074485000940	ABC transporter signature motif; other site
1074485000941	Walker B; other site
1074485000942	D-loop; other site
1074485000943	H-loop/switch region; other site
1074485000944	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1074485000945	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1074485000946	TIGR03943 family protein; Region: TIGR03943
1074485000947	Predicted permease; Region: DUF318; cl17795
1074485000948	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
1074485000949	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485000950	FeS/SAM binding site; other site
1074485000951	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
1074485000952	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1074485000953	effector binding site; other site
1074485000954	active site
1074485000955	Zn binding site [ion binding]; other site
1074485000956	glycine loop; other site
1074485000957	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1074485000958	S17 interaction site [polypeptide binding]; other site
1074485000959	S8 interaction site; other site
1074485000960	16S rRNA interaction site [nucleotide binding]; other site
1074485000961	streptomycin interaction site [chemical binding]; other site
1074485000962	23S rRNA interaction site [nucleotide binding]; other site
1074485000963	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1074485000964	30S ribosomal protein S7; Validated; Region: PRK05302
1074485000965	elongation factor G; Reviewed; Region: PRK00007
1074485000966	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1074485000967	G1 box; other site
1074485000968	putative GEF interaction site [polypeptide binding]; other site
1074485000969	GTP/Mg2+ binding site [chemical binding]; other site
1074485000970	Switch I region; other site
1074485000971	G2 box; other site
1074485000972	G3 box; other site
1074485000973	Switch II region; other site
1074485000974	G4 box; other site
1074485000975	G5 box; other site
1074485000976	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1074485000977	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1074485000978	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1074485000979	elongation factor Tu; Reviewed; Region: PRK00049
1074485000980	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1074485000981	G1 box; other site
1074485000982	GEF interaction site [polypeptide binding]; other site
1074485000983	GTP/Mg2+ binding site [chemical binding]; other site
1074485000984	Switch I region; other site
1074485000985	G2 box; other site
1074485000986	G3 box; other site
1074485000987	Switch II region; other site
1074485000988	G4 box; other site
1074485000989	G5 box; other site
1074485000990	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1074485000991	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1074485000992	Antibiotic Binding Site [chemical binding]; other site
1074485000993	Asp23 family; Region: Asp23; cl00574
1074485000994	Asp23 family; Region: Asp23; cl00574
1074485000995	Asp23 family; Region: Asp23; pfam03780
1074485000996	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1074485000997	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1074485000998	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1074485000999	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1074485001000	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1074485001001	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1074485001002	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1074485001003	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1074485001004	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1074485001005	putative translocon binding site; other site
1074485001006	protein-rRNA interface [nucleotide binding]; other site
1074485001007	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1074485001008	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1074485001009	G-X-X-G motif; other site
1074485001010	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1074485001011	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1074485001012	23S rRNA interface [nucleotide binding]; other site
1074485001013	5S rRNA interface [nucleotide binding]; other site
1074485001014	putative antibiotic binding site [chemical binding]; other site
1074485001015	L25 interface [polypeptide binding]; other site
1074485001016	L27 interface [polypeptide binding]; other site
1074485001017	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1074485001018	putative translocon interaction site; other site
1074485001019	23S rRNA interface [nucleotide binding]; other site
1074485001020	signal recognition particle (SRP54) interaction site; other site
1074485001021	L23 interface [polypeptide binding]; other site
1074485001022	trigger factor interaction site; other site
1074485001023	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1074485001024	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1074485001025	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1074485001026	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1074485001027	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485001028	Walker A/P-loop; other site
1074485001029	ATP binding site [chemical binding]; other site
1074485001030	Q-loop/lid; other site
1074485001031	ABC transporter signature motif; other site
1074485001032	Walker B; other site
1074485001033	D-loop; other site
1074485001034	H-loop/switch region; other site
1074485001035	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485001036	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485001037	Walker A/P-loop; other site
1074485001038	ATP binding site [chemical binding]; other site
1074485001039	Q-loop/lid; other site
1074485001040	ABC transporter signature motif; other site
1074485001041	Walker B; other site
1074485001042	D-loop; other site
1074485001043	H-loop/switch region; other site
1074485001044	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485001045	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1074485001046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001047	dimer interface [polypeptide binding]; other site
1074485001048	conserved gate region; other site
1074485001049	putative PBP binding loops; other site
1074485001050	ABC-ATPase subunit interface; other site
1074485001051	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485001052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001053	putative PBP binding loops; other site
1074485001054	dimer interface [polypeptide binding]; other site
1074485001055	ABC-ATPase subunit interface; other site
1074485001056	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1074485001057	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1074485001058	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1074485001059	RNA binding site [nucleotide binding]; other site
1074485001060	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1074485001061	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1074485001062	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1074485001063	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1074485001064	serine transporter; Region: stp; TIGR00814
1074485001065	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1074485001066	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1074485001067	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1074485001068	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1074485001069	active site
1074485001070	homotetramer interface [polypeptide binding]; other site
1074485001071	homodimer interface [polypeptide binding]; other site
1074485001072	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1074485001073	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597
1074485001074	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1074485001075	ATP binding site [chemical binding]; other site
1074485001076	substrate interface [chemical binding]; other site
1074485001077	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074485001078	active site residue [active]
1074485001079	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1074485001080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485001081	FeS/SAM binding site; other site
1074485001082	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1074485001083	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1074485001084	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1074485001085	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1074485001086	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1074485001087	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1074485001088	5S rRNA interface [nucleotide binding]; other site
1074485001089	23S rRNA interface [nucleotide binding]; other site
1074485001090	L5 interface [polypeptide binding]; other site
1074485001091	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1074485001092	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1074485001093	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1074485001094	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1074485001095	23S rRNA binding site [nucleotide binding]; other site
1074485001096	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1074485001097	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1074485001098	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1074485001099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001100	dimer interface [polypeptide binding]; other site
1074485001101	conserved gate region; other site
1074485001102	putative PBP binding loops; other site
1074485001103	ABC-ATPase subunit interface; other site
1074485001104	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1074485001105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001106	dimer interface [polypeptide binding]; other site
1074485001107	conserved gate region; other site
1074485001108	putative PBP binding loops; other site
1074485001109	ABC-ATPase subunit interface; other site
1074485001110	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1074485001111	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
1074485001112	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1074485001113	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1074485001114	Walker A/P-loop; other site
1074485001115	ATP binding site [chemical binding]; other site
1074485001116	Q-loop/lid; other site
1074485001117	ABC transporter signature motif; other site
1074485001118	Walker B; other site
1074485001119	D-loop; other site
1074485001120	H-loop/switch region; other site
1074485001121	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1074485001122	SecY translocase; Region: SecY; pfam00344
1074485001123	adenylate kinase; Reviewed; Region: adk; PRK00279
1074485001124	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1074485001125	AMP-binding site [chemical binding]; other site
1074485001126	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1074485001127	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1074485001128	active site
1074485001129	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1074485001130	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1074485001131	rRNA binding site [nucleotide binding]; other site
1074485001132	predicted 30S ribosome binding site; other site
1074485001133	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1074485001134	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1074485001135	30S ribosomal protein S11; Validated; Region: PRK05309
1074485001136	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1074485001137	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1074485001138	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485001139	RNA binding surface [nucleotide binding]; other site
1074485001140	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1074485001141	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1074485001142	alphaNTD - beta interaction site [polypeptide binding]; other site
1074485001143	alphaNTD homodimer interface [polypeptide binding]; other site
1074485001144	alphaNTD - beta' interaction site [polypeptide binding]; other site
1074485001145	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1074485001146	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1074485001147	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1074485001148	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1074485001149	dimerization interface 3.5A [polypeptide binding]; other site
1074485001150	active site
1074485001151	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
1074485001152	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1074485001153	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1074485001154	active site
1074485001155	catalytic residues [active]
1074485001156	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
1074485001157	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1074485001158	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074485001159	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1074485001160	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074485001161	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485001162	Walker A/P-loop; other site
1074485001163	ATP binding site [chemical binding]; other site
1074485001164	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1074485001165	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1074485001166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1074485001167	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1074485001168	23S rRNA interface [nucleotide binding]; other site
1074485001169	L3 interface [polypeptide binding]; other site
1074485001170	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1074485001171	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1074485001172	active site
1074485001173	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1074485001174	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1074485001175	active site
1074485001176	substrate binding site [chemical binding]; other site
1074485001177	metal binding site [ion binding]; metal-binding site
1074485001178	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1074485001179	alanine racemase; Reviewed; Region: alr; PRK00053
1074485001180	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1074485001181	active site
1074485001182	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074485001183	dimer interface [polypeptide binding]; other site
1074485001184	substrate binding site [chemical binding]; other site
1074485001185	catalytic residues [active]
1074485001186	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1074485001187	Predicted permease [General function prediction only]; Region: COG2985
1074485001188	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1074485001189	TrkA-C domain; Region: TrkA_C; pfam02080
1074485001190	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1074485001191	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1074485001192	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485001193	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074485001194	Coenzyme A binding pocket [chemical binding]; other site
1074485001195	UGMP family protein; Validated; Region: PRK09604
1074485001196	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1074485001197	oligomerisation interface [polypeptide binding]; other site
1074485001198	mobile loop; other site
1074485001199	roof hairpin; other site
1074485001200	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1074485001201	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1074485001202	ring oligomerisation interface [polypeptide binding]; other site
1074485001203	ATP/Mg binding site [chemical binding]; other site
1074485001204	stacking interactions; other site
1074485001205	hinge regions; other site
1074485001206	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1074485001207	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485001208	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485001209	DNA binding residues [nucleotide binding]
1074485001210	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1074485001211	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1074485001212	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1074485001213	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1074485001214	active site
1074485001215	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1074485001216	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1074485001217	phosphate binding site [ion binding]; other site
1074485001218	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1074485001219	GMP synthase; Reviewed; Region: guaA; PRK00074
1074485001220	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1074485001221	AMP/PPi binding site [chemical binding]; other site
1074485001222	candidate oxyanion hole; other site
1074485001223	catalytic triad [active]
1074485001224	potential glutamine specificity residues [chemical binding]; other site
1074485001225	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1074485001226	ATP Binding subdomain [chemical binding]; other site
1074485001227	Ligand Binding sites [chemical binding]; other site
1074485001228	Dimerization subdomain; other site
1074485001229	PspC domain; Region: PspC; cl00864
1074485001230	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1074485001231	PspC domain; Region: PspC; pfam04024
1074485001232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074485001233	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074485001234	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1074485001235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485001236	active site
1074485001237	phosphorylation site [posttranslational modification]
1074485001238	intermolecular recognition site; other site
1074485001239	dimerization interface [polypeptide binding]; other site
1074485001240	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074485001241	DNA binding residues [nucleotide binding]
1074485001242	AMIN domain; Region: AMIN; pfam11741
1074485001243	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
1074485001244	putative dimer interface [polypeptide binding]; other site
1074485001245	putative [2Fe-2S] cluster binding site [ion binding]; other site
1074485001246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001247	dimer interface [polypeptide binding]; other site
1074485001248	conserved gate region; other site
1074485001249	ABC-ATPase subunit interface; other site
1074485001250	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1074485001251	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1074485001252	Walker A/P-loop; other site
1074485001253	ATP binding site [chemical binding]; other site
1074485001254	Q-loop/lid; other site
1074485001255	ABC transporter signature motif; other site
1074485001256	Walker B; other site
1074485001257	D-loop; other site
1074485001258	H-loop/switch region; other site
1074485001259	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1074485001260	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1074485001261	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1074485001262	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485001263	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1074485001264	intersubunit interface [polypeptide binding]; other site
1074485001265	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074485001266	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074485001267	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074485001268	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485001269	ABC-ATPase subunit  interface; other site
1074485001270	dimer interface [polypeptide binding]; other site
1074485001271	putative PBP binding regions; other site
1074485001272	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074485001273	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1074485001274	ABC-ATPase subunit  interface; other site
1074485001275	dimer interface [polypeptide binding]; other site
1074485001276	putative PBP binding regions; other site
1074485001277	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1074485001278	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1074485001279	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1074485001280	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1074485001281	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1074485001282	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1074485001283	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1074485001284	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1074485001285	homodimer interface [polypeptide binding]; other site
1074485001286	NADP binding site [chemical binding]; other site
1074485001287	substrate binding site [chemical binding]; other site
1074485001288	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1074485001289	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1074485001290	active site
1074485001291	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1074485001292	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1074485001293	Htaa; Region: HtaA; pfam04213
1074485001294	Htaa; Region: HtaA; pfam04213
1074485001295	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1074485001296	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485001297	intersubunit interface [polypeptide binding]; other site
1074485001298	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485001299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485001300	ABC-ATPase subunit  interface; other site
1074485001301	dimer interface [polypeptide binding]; other site
1074485001302	putative PBP binding regions; other site
1074485001303	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1074485001304	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485001305	Walker A/P-loop; other site
1074485001306	ATP binding site [chemical binding]; other site
1074485001307	Q-loop/lid; other site
1074485001308	ABC transporter signature motif; other site
1074485001309	Walker B; other site
1074485001310	D-loop; other site
1074485001311	H-loop/switch region; other site
1074485001312	Htaa; Region: HtaA; pfam04213
1074485001313	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
1074485001314	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1074485001315	homodimer interface [polypeptide binding]; other site
1074485001316	substrate-cofactor binding pocket; other site
1074485001317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485001318	catalytic residue [active]
1074485001319	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1074485001320	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1074485001321	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1074485001322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485001323	putative substrate translocation pore; other site
1074485001324	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1074485001325	putative catalytic site [active]
1074485001326	putative metal binding site [ion binding]; other site
1074485001327	putative phosphate binding site [ion binding]; other site
1074485001328	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1074485001329	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1074485001330	active site
1074485001331	HIGH motif; other site
1074485001332	dimer interface [polypeptide binding]; other site
1074485001333	KMSKS motif; other site
1074485001334	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1074485001335	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1074485001336	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1074485001337	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1074485001338	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1074485001339	NlpC/P60 family; Region: NLPC_P60; pfam00877
1074485001340	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485001341	active site
1074485001342	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074485001343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074485001344	non-specific DNA binding site [nucleotide binding]; other site
1074485001345	salt bridge; other site
1074485001346	sequence-specific DNA binding site [nucleotide binding]; other site
1074485001347	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1074485001348	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1074485001349	active site
1074485001350	substrate binding site [chemical binding]; other site
1074485001351	metal binding site [ion binding]; metal-binding site
1074485001352	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074485001353	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1074485001354	metal binding site [ion binding]; metal-binding site
1074485001355	putative dimer interface [polypeptide binding]; other site
1074485001356	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1074485001357	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074485001358	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074485001359	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074485001360	pyruvate carboxylase; Reviewed; Region: PRK12999
1074485001361	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074485001362	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074485001363	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1074485001364	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1074485001365	active site
1074485001366	catalytic residues [active]
1074485001367	metal binding site [ion binding]; metal-binding site
1074485001368	homodimer binding site [polypeptide binding]; other site
1074485001369	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074485001370	carboxyltransferase (CT) interaction site; other site
1074485001371	biotinylation site [posttranslational modification]; other site
1074485001372	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074485001373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485001374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485001375	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1074485001376	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074485001377	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074485001378	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1074485001379	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074485001380	carboxyltransferase (CT) interaction site; other site
1074485001381	biotinylation site [posttranslational modification]; other site
1074485001382	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1074485001383	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1074485001384	active site residue [active]
1074485001385	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1074485001386	active site residue [active]
1074485001387	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1074485001388	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1074485001389	Maf-like protein; Region: Maf; pfam02545
1074485001390	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1074485001391	active site
1074485001392	dimer interface [polypeptide binding]; other site
1074485001393	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1074485001394	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1074485001395	substrate binding site [chemical binding]; other site
1074485001396	ATP binding site [chemical binding]; other site
1074485001397	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1074485001398	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1074485001399	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1074485001400	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1074485001401	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1074485001402	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1074485001403	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1074485001404	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1074485001405	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1074485001406	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1074485001407	ATP-grasp domain; Region: ATP-grasp; pfam02222
1074485001408	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1074485001409	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1074485001410	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1074485001411	putative active site [active]
1074485001412	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1074485001413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001414	dimer interface [polypeptide binding]; other site
1074485001415	conserved gate region; other site
1074485001416	putative PBP binding loops; other site
1074485001417	ABC-ATPase subunit interface; other site
1074485001418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001419	dimer interface [polypeptide binding]; other site
1074485001420	conserved gate region; other site
1074485001421	putative PBP binding loops; other site
1074485001422	ABC-ATPase subunit interface; other site
1074485001423	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1074485001424	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1074485001425	TIGR03089 family protein; Region: TIGR03089
1074485001426	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1074485001427	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1074485001428	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1074485001429	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1074485001430	Probable Catalytic site; other site
1074485001431	metal-binding site
1074485001432	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1074485001433	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1074485001434	active site
1074485001435	Substrate binding site; other site
1074485001436	Mg++ binding site; other site
1074485001437	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074485001438	putative trimer interface [polypeptide binding]; other site
1074485001439	putative CoA binding site [chemical binding]; other site
1074485001440	Transcription factor WhiB; Region: Whib; pfam02467
1074485001441	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1074485001442	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1074485001443	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1074485001444	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1074485001445	active site
1074485001446	substrate binding site [chemical binding]; other site
1074485001447	metal binding site [ion binding]; metal-binding site
1074485001448	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1074485001449	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1074485001450	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1074485001451	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1074485001452	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
1074485001453	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1074485001454	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1074485001455	homotetramer interface [polypeptide binding]; other site
1074485001456	ligand binding site [chemical binding]; other site
1074485001457	catalytic site [active]
1074485001458	NAD binding site [chemical binding]; other site
1074485001459	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1074485001460	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1074485001461	TMP-binding site; other site
1074485001462	ATP-binding site [chemical binding]; other site
1074485001463	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074485001464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485001465	active site
1074485001466	phosphorylation site [posttranslational modification]
1074485001467	intermolecular recognition site; other site
1074485001468	dimerization interface [polypeptide binding]; other site
1074485001469	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074485001470	DNA binding site [nucleotide binding]
1074485001471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074485001472	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074485001473	dimerization interface [polypeptide binding]; other site
1074485001474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074485001475	dimer interface [polypeptide binding]; other site
1074485001476	phosphorylation site [posttranslational modification]
1074485001477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485001478	ATP binding site [chemical binding]; other site
1074485001479	Mg2+ binding site [ion binding]; other site
1074485001480	G-X-G motif; other site
1074485001481	lipoprotein LpqB; Provisional; Region: PRK13616
1074485001482	Sporulation and spore germination; Region: Germane; pfam10646
1074485001483	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1074485001484	30S subunit binding site; other site
1074485001485	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1074485001486	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074485001487	ATP binding site [chemical binding]; other site
1074485001488	putative Mg++ binding site [ion binding]; other site
1074485001489	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1074485001490	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1074485001491	nucleotide binding region [chemical binding]; other site
1074485001492	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1074485001493	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1074485001494	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1074485001495	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1074485001496	FAD binding pocket [chemical binding]; other site
1074485001497	FAD binding motif [chemical binding]; other site
1074485001498	phosphate binding motif [ion binding]; other site
1074485001499	beta-alpha-beta structure motif; other site
1074485001500	NAD binding pocket [chemical binding]; other site
1074485001501	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1074485001502	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1074485001503	catalytic loop [active]
1074485001504	iron binding site [ion binding]; other site
1074485001505	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1074485001506	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1074485001507	putative di-iron ligands [ion binding]; other site
1074485001508	Predicted GTPases [General function prediction only]; Region: COG1162
1074485001509	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1074485001510	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1074485001511	GTP/Mg2+ binding site [chemical binding]; other site
1074485001512	G4 box; other site
1074485001513	G5 box; other site
1074485001514	G1 box; other site
1074485001515	Switch I region; other site
1074485001516	G2 box; other site
1074485001517	G3 box; other site
1074485001518	Switch II region; other site
1074485001519	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1074485001520	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1074485001521	hinge; other site
1074485001522	active site
1074485001523	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1074485001524	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1074485001525	putative deacylase active site [active]
1074485001526	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1074485001527	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485001528	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485001529	DNA binding residues [nucleotide binding]
1074485001530	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
1074485001531	Transcription factor WhiB; Region: Whib; pfam02467
1074485001532	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1074485001533	active site
1074485001534	catalytic triad [active]
1074485001535	oxyanion hole [active]
1074485001536	PQQ-like domain; Region: PQQ_2; pfam13360
1074485001537	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1074485001538	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1074485001539	ATP binding site [chemical binding]; other site
1074485001540	Mg++ binding site [ion binding]; other site
1074485001541	motif III; other site
1074485001542	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485001543	nucleotide binding region [chemical binding]; other site
1074485001544	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1074485001545	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1074485001546	TIGR02569 family protein; Region: TIGR02569_actnb
1074485001547	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1074485001548	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1074485001549	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1074485001550	Part of AAA domain; Region: AAA_19; pfam13245
1074485001551	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1074485001552	Ion channel; Region: Ion_trans_2; pfam07885
1074485001553	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1074485001554	TrkA-N domain; Region: TrkA_N; pfam02254
1074485001555	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1074485001556	putative NADH binding site [chemical binding]; other site
1074485001557	putative active site [active]
1074485001558	nudix motif; other site
1074485001559	putative metal binding site [ion binding]; other site
1074485001560	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1074485001561	Part of AAA domain; Region: AAA_19; pfam13245
1074485001562	Family description; Region: UvrD_C_2; pfam13538
1074485001563	HRDC domain; Region: HRDC; pfam00570
1074485001564	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1074485001565	Protein of unknown function DUF45; Region: DUF45; cl00636
1074485001566	putative hydrolase; Region: TIGR03624
1074485001567	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1074485001568	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1074485001569	hypothetical protein; Validated; Region: PRK00068
1074485001570	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1074485001571	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1074485001572	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1074485001573	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
1074485001574	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1074485001575	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1074485001576	Predicted membrane protein [Function unknown]; Region: COG2311
1074485001577	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1074485001578	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485001579	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1074485001580	acyl-activating enzyme (AAE) consensus motif; other site
1074485001581	AMP binding site [chemical binding]; other site
1074485001582	active site
1074485001583	CoA binding site [chemical binding]; other site
1074485001584	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1074485001585	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1074485001586	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074485001587	putative trimer interface [polypeptide binding]; other site
1074485001588	putative CoA binding site [chemical binding]; other site
1074485001589	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074485001590	putative trimer interface [polypeptide binding]; other site
1074485001591	putative CoA binding site [chemical binding]; other site
1074485001592	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074485001593	oxaloacetate decarboxylase; Provisional; Region: PRK12330
1074485001594	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1074485001595	active site
1074485001596	catalytic residues [active]
1074485001597	metal binding site [ion binding]; metal-binding site
1074485001598	homodimer binding site [polypeptide binding]; other site
1074485001599	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
1074485001600	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1074485001601	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1074485001602	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074485001603	carboxyltransferase (CT) interaction site; other site
1074485001604	biotinylation site [posttranslational modification]; other site
1074485001605	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074485001606	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1074485001607	active site
1074485001608	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1074485001609	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074485001610	active site
1074485001611	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1074485001612	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1074485001613	RF-1 domain; Region: RF-1; pfam00472
1074485001614	topology modulation protein; Provisional; Region: PRK07261
1074485001615	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
1074485001616	active site
1074485001617	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
1074485001618	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1074485001619	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1074485001620	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485001621	Walker A/P-loop; other site
1074485001622	ATP binding site [chemical binding]; other site
1074485001623	Q-loop/lid; other site
1074485001624	ABC transporter signature motif; other site
1074485001625	Walker B; other site
1074485001626	D-loop; other site
1074485001627	H-loop/switch region; other site
1074485001628	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1074485001629	FtsX-like permease family; Region: FtsX; pfam02687
1074485001630	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1074485001631	SmpB-tmRNA interface; other site
1074485001632	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1074485001633	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1074485001634	active site clefts [active]
1074485001635	zinc binding site [ion binding]; other site
1074485001636	dimer interface [polypeptide binding]; other site
1074485001637	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1074485001638	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485001639	intersubunit interface [polypeptide binding]; other site
1074485001640	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485001641	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485001642	ABC-ATPase subunit  interface; other site
1074485001643	dimer interface [polypeptide binding]; other site
1074485001644	putative PBP binding regions; other site
1074485001645	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485001646	ABC-ATPase subunit  interface; other site
1074485001647	dimer interface [polypeptide binding]; other site
1074485001648	putative PBP binding regions; other site
1074485001649	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1074485001650	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485001651	Walker A/P-loop; other site
1074485001652	ATP binding site [chemical binding]; other site
1074485001653	Q-loop/lid; other site
1074485001654	ABC transporter signature motif; other site
1074485001655	Walker B; other site
1074485001656	D-loop; other site
1074485001657	H-loop/switch region; other site
1074485001658	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
1074485001659	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1074485001660	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1074485001661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485001662	ATP binding site [chemical binding]; other site
1074485001663	putative Mg++ binding site [ion binding]; other site
1074485001664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485001665	nucleotide binding region [chemical binding]; other site
1074485001666	ATP-binding site [chemical binding]; other site
1074485001667	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1074485001668	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1074485001669	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
1074485001670	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1074485001671	DNA-binding site [nucleotide binding]; DNA binding site
1074485001672	RNA-binding motif; other site
1074485001673	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1074485001674	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1074485001675	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1074485001676	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1074485001677	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074485001678	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074485001679	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1074485001680	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074485001681	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074485001682	catalytic residue [active]
1074485001683	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1074485001684	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1074485001685	dimer interface [polypeptide binding]; other site
1074485001686	active site
1074485001687	citrylCoA binding site [chemical binding]; other site
1074485001688	NADH binding [chemical binding]; other site
1074485001689	cationic pore residues; other site
1074485001690	oxalacetate/citrate binding site [chemical binding]; other site
1074485001691	coenzyme A binding site [chemical binding]; other site
1074485001692	catalytic triad [active]
1074485001693	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1074485001694	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1074485001695	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1074485001696	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1074485001697	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1074485001698	E-class dimer interface [polypeptide binding]; other site
1074485001699	P-class dimer interface [polypeptide binding]; other site
1074485001700	active site
1074485001701	Cu2+ binding site [ion binding]; other site
1074485001702	Zn2+ binding site [ion binding]; other site
1074485001703	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074485001704	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074485001705	active site
1074485001706	catalytic tetrad [active]
1074485001707	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1074485001708	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074485001709	substrate binding site [chemical binding]; other site
1074485001710	oxyanion hole (OAH) forming residues; other site
1074485001711	trimer interface [polypeptide binding]; other site
1074485001712	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1074485001713	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1074485001714	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1074485001715	Na binding site [ion binding]; other site
1074485001716	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1074485001717	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1074485001718	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1074485001719	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1074485001720	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1074485001721	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1074485001722	multidrug efflux protein NorA; Provisional; Region: PRK00187
1074485001723	cation binding site [ion binding]; other site
1074485001724	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1074485001725	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074485001726	dimer interface [polypeptide binding]; other site
1074485001727	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485001728	catalytic residue [active]
1074485001729	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1074485001730	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074485001731	catalytic residue [active]
1074485001732	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1074485001733	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1074485001734	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1074485001735	substrate binding pocket [chemical binding]; other site
1074485001736	active site
1074485001737	iron coordination sites [ion binding]; other site
1074485001738	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485001739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001740	dimer interface [polypeptide binding]; other site
1074485001741	conserved gate region; other site
1074485001742	putative PBP binding loops; other site
1074485001743	ABC-ATPase subunit interface; other site
1074485001744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074485001745	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1074485001746	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485001747	Walker A/P-loop; other site
1074485001748	ATP binding site [chemical binding]; other site
1074485001749	Q-loop/lid; other site
1074485001750	ABC transporter signature motif; other site
1074485001751	Walker B; other site
1074485001752	D-loop; other site
1074485001753	H-loop/switch region; other site
1074485001754	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485001755	Walker A/P-loop; other site
1074485001756	ATP binding site [chemical binding]; other site
1074485001757	Q-loop/lid; other site
1074485001758	ABC transporter signature motif; other site
1074485001759	Walker B; other site
1074485001760	D-loop; other site
1074485001761	H-loop/switch region; other site
1074485001762	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1074485001763	active site
1074485001764	SAM binding site [chemical binding]; other site
1074485001765	homodimer interface [polypeptide binding]; other site
1074485001766	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1074485001767	catalytic residues [active]
1074485001768	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1074485001769	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1074485001770	folate binding site [chemical binding]; other site
1074485001771	NADP+ binding site [chemical binding]; other site
1074485001772	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1074485001773	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1074485001774	dimerization interface [polypeptide binding]; other site
1074485001775	active site
1074485001776	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1074485001777	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074485001778	active site
1074485001779	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485001780	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1074485001781	ATP binding site [chemical binding]; other site
1074485001782	putative Mg++ binding site [ion binding]; other site
1074485001783	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485001784	nucleotide binding region [chemical binding]; other site
1074485001785	ATP-binding site [chemical binding]; other site
1074485001786	DEAD/H associated; Region: DEAD_assoc; pfam08494
1074485001787	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1074485001788	active site
1074485001789	SUMO-1 interface [polypeptide binding]; other site
1074485001790	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1074485001791	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1074485001792	putative DNA binding site [nucleotide binding]; other site
1074485001793	catalytic residue [active]
1074485001794	putative H2TH interface [polypeptide binding]; other site
1074485001795	putative catalytic residues [active]
1074485001796	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1074485001797	hypothetical protein; Provisional; Region: PRK11770
1074485001798	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1074485001799	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1074485001800	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1074485001801	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1074485001802	active site
1074485001803	dimer interface [polypeptide binding]; other site
1074485001804	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1074485001805	dimer interface [polypeptide binding]; other site
1074485001806	active site
1074485001807	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1074485001808	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1074485001809	tetramerization interface [polypeptide binding]; other site
1074485001810	NAD(P) binding site [chemical binding]; other site
1074485001811	catalytic residues [active]
1074485001812	hypothetical protein; Provisional; Region: PRK07857
1074485001813	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1074485001814	Part of AAA domain; Region: AAA_19; pfam13245
1074485001815	Family description; Region: UvrD_C_2; pfam13538
1074485001816	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074485001817	Peptidase family M23; Region: Peptidase_M23; pfam01551
1074485001818	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
1074485001819	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1074485001820	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1074485001821	active site
1074485001822	substrate binding site [chemical binding]; other site
1074485001823	cosubstrate binding site; other site
1074485001824	catalytic site [active]
1074485001825	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1074485001826	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1074485001827	purine monophosphate binding site [chemical binding]; other site
1074485001828	dimer interface [polypeptide binding]; other site
1074485001829	putative catalytic residues [active]
1074485001830	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1074485001831	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1074485001832	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1074485001833	Walker A/P-loop; other site
1074485001834	ATP binding site [chemical binding]; other site
1074485001835	Q-loop/lid; other site
1074485001836	ABC transporter signature motif; other site
1074485001837	Walker B; other site
1074485001838	D-loop; other site
1074485001839	H-loop/switch region; other site
1074485001840	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1074485001841	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074485001842	substrate binding pocket [chemical binding]; other site
1074485001843	membrane-bound complex binding site; other site
1074485001844	hinge residues; other site
1074485001845	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1074485001846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001847	dimer interface [polypeptide binding]; other site
1074485001848	conserved gate region; other site
1074485001849	putative PBP binding loops; other site
1074485001850	ABC-ATPase subunit interface; other site
1074485001851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485001852	dimer interface [polypeptide binding]; other site
1074485001853	conserved gate region; other site
1074485001854	putative PBP binding loops; other site
1074485001855	ABC-ATPase subunit interface; other site
1074485001856	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1074485001857	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485001858	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485001859	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
1074485001860	30S ribosomal protein S18; Provisional; Region: PRK13401
1074485001861	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1074485001862	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1074485001863	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1074485001864	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1074485001865	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1074485001866	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074485001867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485001868	active site
1074485001869	phosphorylation site [posttranslational modification]
1074485001870	intermolecular recognition site; other site
1074485001871	dimerization interface [polypeptide binding]; other site
1074485001872	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074485001873	DNA binding site [nucleotide binding]
1074485001874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074485001875	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074485001876	dimerization interface [polypeptide binding]; other site
1074485001877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074485001878	dimer interface [polypeptide binding]; other site
1074485001879	phosphorylation site [posttranslational modification]
1074485001880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485001881	ATP binding site [chemical binding]; other site
1074485001882	Mg2+ binding site [ion binding]; other site
1074485001883	G-X-G motif; other site
1074485001884	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1074485001885	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1074485001886	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1074485001887	protein binding site [polypeptide binding]; other site
1074485001888	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1074485001889	MPT binding site; other site
1074485001890	trimer interface [polypeptide binding]; other site
1074485001891	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1074485001892	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1074485001893	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1074485001894	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1074485001895	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1074485001896	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
1074485001897	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1074485001898	active site
1074485001899	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1074485001900	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1074485001901	dimer interface [polypeptide binding]; other site
1074485001902	putative functional site; other site
1074485001903	putative MPT binding site; other site
1074485001904	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074485001905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074485001906	Predicted membrane protein [Function unknown]; Region: COG2259
1074485001907	Predicted integral membrane protein [Function unknown]; Region: COG5660
1074485001908	Putative zinc-finger; Region: zf-HC2; pfam13490
1074485001909	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1074485001910	BCCT family transporter; Region: BCCT; pfam02028
1074485001911	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1074485001912	Predicted methyltransferases [General function prediction only]; Region: COG0313
1074485001913	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1074485001914	putative SAM binding site [chemical binding]; other site
1074485001915	putative homodimer interface [polypeptide binding]; other site
1074485001916	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1074485001917	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1074485001918	active site
1074485001919	HIGH motif; other site
1074485001920	KMSKS motif; other site
1074485001921	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1074485001922	tRNA binding surface [nucleotide binding]; other site
1074485001923	anticodon binding site; other site
1074485001924	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1074485001925	active site
1074485001926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1074485001927	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1074485001928	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1074485001929	G5 domain; Region: G5; pfam07501
1074485001930	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1074485001931	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1074485001932	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1074485001933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074485001934	ABC transporter; Region: ABC_tran_2; pfam12848
1074485001935	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074485001936	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1074485001937	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1074485001938	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1074485001939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485001940	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1074485001941	active site
1074485001942	motif I; other site
1074485001943	motif II; other site
1074485001944	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1074485001945	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1074485001946	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074485001947	substrate binding site [chemical binding]; other site
1074485001948	oxyanion hole (OAH) forming residues; other site
1074485001949	trimer interface [polypeptide binding]; other site
1074485001950	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1074485001951	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1074485001952	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1074485001953	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074485001954	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1074485001955	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1074485001956	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1074485001957	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1074485001958	G1 box; other site
1074485001959	putative GEF interaction site [polypeptide binding]; other site
1074485001960	GTP/Mg2+ binding site [chemical binding]; other site
1074485001961	Switch I region; other site
1074485001962	G2 box; other site
1074485001963	G3 box; other site
1074485001964	Switch II region; other site
1074485001965	G4 box; other site
1074485001966	G5 box; other site
1074485001967	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1074485001968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485001969	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
1074485001970	NAD(P) binding site [chemical binding]; other site
1074485001971	active site
1074485001972	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1074485001973	putative active site [active]
1074485001974	catalytic residue [active]
1074485001975	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1074485001976	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1074485001977	FMN binding site [chemical binding]; other site
1074485001978	substrate binding site [chemical binding]; other site
1074485001979	putative catalytic residue [active]
1074485001980	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1074485001981	putative active site [active]
1074485001982	catalytic residue [active]
1074485001983	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1074485001984	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1074485001985	5S rRNA interface [nucleotide binding]; other site
1074485001986	CTC domain interface [polypeptide binding]; other site
1074485001987	L16 interface [polypeptide binding]; other site
1074485001988	pullulanase, type I; Region: pulA_typeI; TIGR02104
1074485001989	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1074485001990	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1074485001991	Ca binding site [ion binding]; other site
1074485001992	active site
1074485001993	catalytic site [active]
1074485001994	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1074485001995	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1074485001996	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485001997	active site
1074485001998	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1074485001999	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1074485002000	Substrate binding site; other site
1074485002001	Mg++ binding site; other site
1074485002002	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1074485002003	active site
1074485002004	substrate binding site [chemical binding]; other site
1074485002005	CoA binding site [chemical binding]; other site
1074485002006	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
1074485002007	gating phenylalanine in ion channel; other site
1074485002008	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485002009	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485002010	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1074485002011	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1074485002012	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485002013	ATP binding site [chemical binding]; other site
1074485002014	putative Mg++ binding site [ion binding]; other site
1074485002015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485002016	nucleotide binding region [chemical binding]; other site
1074485002017	ATP-binding site [chemical binding]; other site
1074485002018	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1074485002019	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1074485002020	Spore germination protein; Region: Spore_permease; cl17796
1074485002021	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1074485002022	homodimer interface [polypeptide binding]; other site
1074485002023	metal binding site [ion binding]; metal-binding site
1074485002024	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1074485002025	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1074485002026	enolase; Provisional; Region: eno; PRK00077
1074485002027	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1074485002028	dimer interface [polypeptide binding]; other site
1074485002029	metal binding site [ion binding]; metal-binding site
1074485002030	substrate binding pocket [chemical binding]; other site
1074485002031	Septum formation initiator; Region: DivIC; pfam04977
1074485002032	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1074485002033	Uncharacterized conserved protein [Function unknown]; Region: COG1507
1074485002034	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1074485002035	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1074485002036	Helix-turn-helix domain; Region: HTH_18; pfam12833
1074485002037	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074485002038	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1074485002039	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1074485002040	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1074485002041	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1074485002042	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1074485002043	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1074485002044	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1074485002045	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1074485002046	catalytic residue [active]
1074485002047	putative FPP diphosphate  binding site; other site
1074485002048	putative FPP binding hydrophobic cleft; other site
1074485002049	dimer interface [polypeptide binding]; other site
1074485002050	putative IPP diphosphate binding site; other site
1074485002051	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
1074485002052	pantothenate kinase; Provisional; Region: PRK05439
1074485002053	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1074485002054	ATP-binding site [chemical binding]; other site
1074485002055	CoA-binding site [chemical binding]; other site
1074485002056	Mg2+-binding site [ion binding]; other site
1074485002057	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1074485002058	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1074485002059	dimer interface [polypeptide binding]; other site
1074485002060	active site
1074485002061	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1074485002062	folate binding site [chemical binding]; other site
1074485002063	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074485002064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485002065	putative substrate translocation pore; other site
1074485002066	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485002067	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485002068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074485002069	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074485002070	dimerization interface [polypeptide binding]; other site
1074485002071	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1074485002072	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1074485002073	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485002074	Coenzyme A binding pocket [chemical binding]; other site
1074485002075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485002076	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1074485002077	putative substrate translocation pore; other site
1074485002078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485002079	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485002080	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1074485002081	Class II fumarases; Region: Fumarase_classII; cd01362
1074485002082	active site
1074485002083	tetramer interface [polypeptide binding]; other site
1074485002084	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1074485002085	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1074485002086	putative active site [active]
1074485002087	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1074485002088	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1074485002089	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1074485002090	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1074485002091	generic binding surface II; other site
1074485002092	generic binding surface I; other site
1074485002093	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1074485002094	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1074485002095	GTP-binding protein YchF; Reviewed; Region: PRK09601
1074485002096	YchF GTPase; Region: YchF; cd01900
1074485002097	G1 box; other site
1074485002098	GTP/Mg2+ binding site [chemical binding]; other site
1074485002099	Switch I region; other site
1074485002100	G2 box; other site
1074485002101	Switch II region; other site
1074485002102	G3 box; other site
1074485002103	G4 box; other site
1074485002104	G5 box; other site
1074485002105	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1074485002106	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1074485002107	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1074485002108	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1074485002109	PhnA protein; Region: PhnA; pfam03831
1074485002110	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074485002111	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1074485002112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002113	Walker A/P-loop; other site
1074485002114	ATP binding site [chemical binding]; other site
1074485002115	Q-loop/lid; other site
1074485002116	ABC transporter signature motif; other site
1074485002117	Walker B; other site
1074485002118	D-loop; other site
1074485002119	H-loop/switch region; other site
1074485002120	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1074485002121	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074485002122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002123	Walker A/P-loop; other site
1074485002124	ATP binding site [chemical binding]; other site
1074485002125	Q-loop/lid; other site
1074485002126	ABC transporter signature motif; other site
1074485002127	Walker B; other site
1074485002128	D-loop; other site
1074485002129	H-loop/switch region; other site
1074485002130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002131	Walker A/P-loop; other site
1074485002132	ATP binding site [chemical binding]; other site
1074485002133	Q-loop/lid; other site
1074485002134	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074485002135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002136	Walker A/P-loop; other site
1074485002137	ATP binding site [chemical binding]; other site
1074485002138	Q-loop/lid; other site
1074485002139	ABC transporter; Region: ABC_tran; pfam00005
1074485002140	ABC transporter signature motif; other site
1074485002141	Walker B; other site
1074485002142	D-loop; other site
1074485002143	H-loop/switch region; other site
1074485002144	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
1074485002145	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1074485002146	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1074485002147	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1074485002148	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1074485002149	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074485002150	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074485002151	Walker A/P-loop; other site
1074485002152	ATP binding site [chemical binding]; other site
1074485002153	Q-loop/lid; other site
1074485002154	ABC transporter signature motif; other site
1074485002155	Walker B; other site
1074485002156	D-loop; other site
1074485002157	H-loop/switch region; other site
1074485002158	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074485002159	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1074485002160	Walker A/P-loop; other site
1074485002161	ATP binding site [chemical binding]; other site
1074485002162	Q-loop/lid; other site
1074485002163	ABC transporter signature motif; other site
1074485002164	Walker B; other site
1074485002165	D-loop; other site
1074485002166	H-loop/switch region; other site
1074485002167	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074485002168	hypothetical protein; Provisional; Region: PRK06547
1074485002169	AAA domain; Region: AAA_18; pfam13238
1074485002170	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1074485002171	nudix motif; other site
1074485002172	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1074485002173	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1074485002174	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485002175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485002176	dimer interface [polypeptide binding]; other site
1074485002177	conserved gate region; other site
1074485002178	ABC-ATPase subunit interface; other site
1074485002179	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074485002180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485002181	dimer interface [polypeptide binding]; other site
1074485002182	conserved gate region; other site
1074485002183	putative PBP binding loops; other site
1074485002184	ABC-ATPase subunit interface; other site
1074485002185	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1074485002186	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485002187	Walker A/P-loop; other site
1074485002188	ATP binding site [chemical binding]; other site
1074485002189	Q-loop/lid; other site
1074485002190	ABC transporter signature motif; other site
1074485002191	Walker B; other site
1074485002192	D-loop; other site
1074485002193	H-loop/switch region; other site
1074485002194	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485002195	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485002196	Walker A/P-loop; other site
1074485002197	ATP binding site [chemical binding]; other site
1074485002198	Q-loop/lid; other site
1074485002199	ABC transporter signature motif; other site
1074485002200	Walker B; other site
1074485002201	D-loop; other site
1074485002202	H-loop/switch region; other site
1074485002203	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485002204	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1074485002205	cleavage site
1074485002206	active site
1074485002207	substrate binding sites [chemical binding]; other site
1074485002208	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1074485002209	ArsC family; Region: ArsC; pfam03960
1074485002210	catalytic residues [active]
1074485002211	Protein of unknown function (DUF402); Region: DUF402; cl00979
1074485002212	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1074485002213	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1074485002214	G1 box; other site
1074485002215	GTP/Mg2+ binding site [chemical binding]; other site
1074485002216	G2 box; other site
1074485002217	Switch I region; other site
1074485002218	G3 box; other site
1074485002219	Switch II region; other site
1074485002220	G4 box; other site
1074485002221	G5 box; other site
1074485002222	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1074485002223	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1074485002224	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1074485002225	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1074485002226	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1074485002227	Ferredoxin [Energy production and conversion]; Region: COG1146
1074485002228	4Fe-4S binding domain; Region: Fer4; pfam00037
1074485002229	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1074485002230	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485002231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485002232	homodimer interface [polypeptide binding]; other site
1074485002233	catalytic residue [active]
1074485002234	Predicted membrane protein [Function unknown]; Region: COG2246
1074485002235	GtrA-like protein; Region: GtrA; pfam04138
1074485002236	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1074485002237	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1074485002238	active site
1074485002239	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074485002240	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1074485002241	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1074485002242	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1074485002243	putative trimer interface [polypeptide binding]; other site
1074485002244	putative CoA binding site [chemical binding]; other site
1074485002245	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074485002246	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1074485002247	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1074485002248	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074485002249	putative trimer interface [polypeptide binding]; other site
1074485002250	putative CoA binding site [chemical binding]; other site
1074485002251	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1074485002252	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1074485002253	metal binding site [ion binding]; metal-binding site
1074485002254	putative dimer interface [polypeptide binding]; other site
1074485002255	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1074485002256	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1074485002257	dihydropteroate synthase; Region: DHPS; TIGR01496
1074485002258	substrate binding pocket [chemical binding]; other site
1074485002259	dimer interface [polypeptide binding]; other site
1074485002260	inhibitor binding site; inhibition site
1074485002261	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1074485002262	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1074485002263	Ligand binding site; other site
1074485002264	Putative Catalytic site; other site
1074485002265	DXD motif; other site
1074485002266	DivIVA domain; Region: DivI1A_domain; TIGR03544
1074485002267	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1074485002268	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1074485002269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002270	S-adenosylmethionine binding site [chemical binding]; other site
1074485002271	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1074485002272	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1074485002273	active site
1074485002274	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1074485002275	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1074485002276	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1074485002277	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1074485002278	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1074485002279	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1074485002280	ligand binding site; other site
1074485002281	oligomer interface; other site
1074485002282	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1074485002283	dimer interface [polypeptide binding]; other site
1074485002284	N-terminal domain interface [polypeptide binding]; other site
1074485002285	sulfate 1 binding site; other site
1074485002286	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1074485002287	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1074485002288	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485002289	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485002290	DNA binding residues [nucleotide binding]
1074485002291	sec-independent translocase; Provisional; Region: tatB; PRK00182
1074485002292	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1074485002293	antiporter inner membrane protein; Provisional; Region: PRK11670
1074485002294	Domain of unknown function DUF59; Region: DUF59; pfam01883
1074485002295	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1074485002296	Predicted membrane protein [Function unknown]; Region: COG4420
1074485002297	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1074485002298	MgtE intracellular N domain; Region: MgtE_N; smart00924
1074485002299	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1074485002300	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1074485002301	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1074485002302	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074485002303	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1074485002304	TPP-binding site [chemical binding]; other site
1074485002305	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1074485002306	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074485002307	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074485002308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002309	Walker A/P-loop; other site
1074485002310	ATP binding site [chemical binding]; other site
1074485002311	Q-loop/lid; other site
1074485002312	ABC transporter signature motif; other site
1074485002313	Walker B; other site
1074485002314	D-loop; other site
1074485002315	H-loop/switch region; other site
1074485002316	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074485002317	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074485002318	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002319	Walker A/P-loop; other site
1074485002320	ATP binding site [chemical binding]; other site
1074485002321	Q-loop/lid; other site
1074485002322	ABC transporter signature motif; other site
1074485002323	Walker B; other site
1074485002324	D-loop; other site
1074485002325	H-loop/switch region; other site
1074485002326	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1074485002327	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1074485002328	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1074485002329	shikimate binding site; other site
1074485002330	NAD(P) binding site [chemical binding]; other site
1074485002331	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1074485002332	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1074485002333	substrate binding pocket [chemical binding]; other site
1074485002334	catalytic triad [active]
1074485002335	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1074485002336	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1074485002337	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1074485002338	active site
1074485002339	catalytic residues [active]
1074485002340	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
1074485002341	putative transporter; Provisional; Region: PRK10484
1074485002342	Na binding site [ion binding]; other site
1074485002343	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1074485002344	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1074485002345	nucleotide binding site/active site [active]
1074485002346	HIT family signature motif; other site
1074485002347	catalytic residue [active]
1074485002348	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1074485002349	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1074485002350	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074485002351	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1074485002352	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1074485002353	ATP binding site [chemical binding]; other site
1074485002354	Mg++ binding site [ion binding]; other site
1074485002355	motif III; other site
1074485002356	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485002357	nucleotide binding region [chemical binding]; other site
1074485002358	ATP-binding site [chemical binding]; other site
1074485002359	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1074485002360	putative RNA binding site [nucleotide binding]; other site
1074485002361	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1074485002362	dimer interface [polypeptide binding]; other site
1074485002363	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074485002364	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1074485002365	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1074485002366	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1074485002367	Na binding site [ion binding]; other site
1074485002368	SNF2 Helicase protein; Region: DUF3670; pfam12419
1074485002369	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1074485002370	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485002371	ATP binding site [chemical binding]; other site
1074485002372	putative Mg++ binding site [ion binding]; other site
1074485002373	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485002374	nucleotide binding region [chemical binding]; other site
1074485002375	ATP-binding site [chemical binding]; other site
1074485002376	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1074485002377	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1074485002378	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1074485002379	active site
1074485002380	metal binding site [ion binding]; metal-binding site
1074485002381	DNA binding site [nucleotide binding]
1074485002382	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
1074485002383	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1074485002384	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074485002385	MarR family; Region: MarR_2; pfam12802
1074485002386	PspC domain; Region: PspC; pfam04024
1074485002387	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074485002388	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1074485002389	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074485002390	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1074485002391	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1074485002392	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1074485002393	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1074485002394	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1074485002395	Cysteine-rich domain; Region: CCG; pfam02754
1074485002396	Cysteine-rich domain; Region: CCG; pfam02754
1074485002397	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1074485002398	L-lactate permease; Region: Lactate_perm; cl00701
1074485002399	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1074485002400	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1074485002401	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1074485002402	active site
1074485002403	HIGH motif; other site
1074485002404	KMSK motif region; other site
1074485002405	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1074485002406	tRNA binding surface [nucleotide binding]; other site
1074485002407	anticodon binding site; other site
1074485002408	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1074485002409	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1074485002410	active site
1074485002411	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074485002412	substrate binding site [chemical binding]; other site
1074485002413	catalytic residues [active]
1074485002414	dimer interface [polypeptide binding]; other site
1074485002415	homoserine dehydrogenase; Provisional; Region: PRK06349
1074485002416	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1074485002417	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1074485002418	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1074485002419	homoserine kinase; Provisional; Region: PRK01212
1074485002420	Predicted transcriptional regulator [Transcription]; Region: COG2345
1074485002421	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
1074485002422	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
1074485002423	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485002424	acyl-activating enzyme (AAE) consensus motif; other site
1074485002425	AMP binding site [chemical binding]; other site
1074485002426	active site
1074485002427	CoA binding site [chemical binding]; other site
1074485002428	transcription termination factor Rho; Provisional; Region: PRK12678
1074485002429	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1074485002430	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1074485002431	RNA binding site [nucleotide binding]; other site
1074485002432	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1074485002433	multimer interface [polypeptide binding]; other site
1074485002434	Walker A motif; other site
1074485002435	ATP binding site [chemical binding]; other site
1074485002436	Walker B motif; other site
1074485002437	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1074485002438	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1074485002439	RF-1 domain; Region: RF-1; pfam00472
1074485002440	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1074485002441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002442	S-adenosylmethionine binding site [chemical binding]; other site
1074485002443	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1074485002444	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1074485002445	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1074485002446	Mg++ binding site [ion binding]; other site
1074485002447	putative catalytic motif [active]
1074485002448	substrate binding site [chemical binding]; other site
1074485002449	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1074485002450	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1074485002451	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
1074485002452	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1074485002453	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1074485002454	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1074485002455	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1074485002456	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1074485002457	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1074485002458	beta subunit interaction interface [polypeptide binding]; other site
1074485002459	Walker A motif; other site
1074485002460	ATP binding site [chemical binding]; other site
1074485002461	Walker B motif; other site
1074485002462	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1074485002463	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1074485002464	core domain interface [polypeptide binding]; other site
1074485002465	delta subunit interface [polypeptide binding]; other site
1074485002466	epsilon subunit interface [polypeptide binding]; other site
1074485002467	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1074485002468	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1074485002469	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1074485002470	alpha subunit interaction interface [polypeptide binding]; other site
1074485002471	Walker A motif; other site
1074485002472	ATP binding site [chemical binding]; other site
1074485002473	Walker B motif; other site
1074485002474	inhibitor binding site; inhibition site
1074485002475	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1074485002476	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1074485002477	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1074485002478	gamma subunit interface [polypeptide binding]; other site
1074485002479	epsilon subunit interface [polypeptide binding]; other site
1074485002480	LBP interface [polypeptide binding]; other site
1074485002481	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1074485002482	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1074485002483	hypothetical protein; Provisional; Region: PRK03298
1074485002484	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1074485002485	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074485002486	dimer interface [polypeptide binding]; other site
1074485002487	substrate binding site [chemical binding]; other site
1074485002488	metal binding site [ion binding]; metal-binding site
1074485002489	Domain of unknown function DUF77; Region: DUF77; pfam01910
1074485002490	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1074485002491	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1074485002492	glycogen branching enzyme; Provisional; Region: PRK05402
1074485002493	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1074485002494	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1074485002495	active site
1074485002496	catalytic site [active]
1074485002497	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1074485002498	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1074485002499	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1074485002500	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1074485002501	active site
1074485002502	catalytic site [active]
1074485002503	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074485002504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485002505	Walker A/P-loop; other site
1074485002506	ATP binding site [chemical binding]; other site
1074485002507	ABC transporter signature motif; other site
1074485002508	Walker B; other site
1074485002509	D-loop; other site
1074485002510	H-loop/switch region; other site
1074485002511	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1074485002512	Ligand binding site [chemical binding]; other site
1074485002513	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1074485002514	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1074485002515	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1074485002516	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1074485002517	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1074485002518	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1074485002519	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074485002520	catalytic residue [active]
1074485002521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002522	S-adenosylmethionine binding site [chemical binding]; other site
1074485002523	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1074485002524	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1074485002525	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1074485002526	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1074485002527	active site
1074485002528	catalytic site [active]
1074485002529	substrate binding site [chemical binding]; other site
1074485002530	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1074485002531	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1074485002532	nucleotide binding pocket [chemical binding]; other site
1074485002533	K-X-D-G motif; other site
1074485002534	catalytic site [active]
1074485002535	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1074485002536	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1074485002537	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1074485002538	Dimer interface [polypeptide binding]; other site
1074485002539	BRCT sequence motif; other site
1074485002540	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1074485002541	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1074485002542	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1074485002543	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1074485002544	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074485002545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485002546	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074485002547	putative substrate translocation pore; other site
1074485002548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485002549	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485002550	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485002551	ABC-ATPase subunit  interface; other site
1074485002552	dimer interface [polypeptide binding]; other site
1074485002553	putative PBP binding regions; other site
1074485002554	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074485002555	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485002556	Walker A/P-loop; other site
1074485002557	ATP binding site [chemical binding]; other site
1074485002558	Q-loop/lid; other site
1074485002559	ABC transporter signature motif; other site
1074485002560	Walker B; other site
1074485002561	D-loop; other site
1074485002562	H-loop/switch region; other site
1074485002563	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1074485002564	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1074485002565	putative ligand binding residues [chemical binding]; other site
1074485002566	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1074485002567	phosphofructokinase; Region: PFK_mixed; TIGR02483
1074485002568	active site
1074485002569	ADP/pyrophosphate binding site [chemical binding]; other site
1074485002570	dimerization interface [polypeptide binding]; other site
1074485002571	allosteric effector site; other site
1074485002572	fructose-1,6-bisphosphate binding site; other site
1074485002573	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1074485002574	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1074485002575	GatB domain; Region: GatB_Yqey; smart00845
1074485002576	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074485002577	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074485002578	active site
1074485002579	catalytic tetrad [active]
1074485002580	Lysine efflux permease [General function prediction only]; Region: COG1279
1074485002581	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1074485002582	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074485002583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1074485002584	dimerization interface [polypeptide binding]; other site
1074485002585	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1074485002586	Predicted membrane protein [Function unknown]; Region: COG2259
1074485002587	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1074485002588	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1074485002589	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1074485002590	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1074485002591	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1074485002592	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1074485002593	PYR/PP interface [polypeptide binding]; other site
1074485002594	dimer interface [polypeptide binding]; other site
1074485002595	TPP binding site [chemical binding]; other site
1074485002596	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074485002597	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1074485002598	TPP-binding site [chemical binding]; other site
1074485002599	dimer interface [polypeptide binding]; other site
1074485002600	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1074485002601	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1074485002602	putative valine binding site [chemical binding]; other site
1074485002603	dimer interface [polypeptide binding]; other site
1074485002604	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1074485002605	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1074485002606	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1074485002607	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1074485002608	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1074485002609	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1074485002610	Protein of unknown function DUF262; Region: DUF262; pfam03235
1074485002611	Uncharacterized conserved protein [Function unknown]; Region: COG3472
1074485002612	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1074485002613	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1074485002614	ligand binding site [chemical binding]; other site
1074485002615	NAD binding site [chemical binding]; other site
1074485002616	dimerization interface [polypeptide binding]; other site
1074485002617	catalytic site [active]
1074485002618	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1074485002619	putative L-serine binding site [chemical binding]; other site
1074485002620	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1074485002621	tartrate dehydrogenase; Region: TTC; TIGR02089
1074485002622	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1074485002623	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1074485002624	ligand binding site [chemical binding]; other site
1074485002625	flexible hinge region; other site
1074485002626	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
1074485002627	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1074485002628	metal binding triad; other site
1074485002629	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1074485002630	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1074485002631	active site
1074485002632	catalytic site [active]
1074485002633	substrate binding site [chemical binding]; other site
1074485002634	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1074485002635	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1074485002636	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1074485002637	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1074485002638	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1074485002639	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1074485002640	active site
1074485002641	HIGH motif; other site
1074485002642	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1074485002643	active site
1074485002644	KMSKS motif; other site
1074485002645	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1074485002646	Cutinase; Region: Cutinase; pfam01083
1074485002647	biotin synthase; Region: bioB; TIGR00433
1074485002648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485002649	FeS/SAM binding site; other site
1074485002650	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1074485002651	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1074485002652	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074485002653	Zn2+ binding site [ion binding]; other site
1074485002654	Mg2+ binding site [ion binding]; other site
1074485002655	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1074485002656	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1074485002657	Bacterial transcriptional regulator; Region: IclR; pfam01614
1074485002658	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1074485002659	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1074485002660	substrate binding site [chemical binding]; other site
1074485002661	ligand binding site [chemical binding]; other site
1074485002662	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1074485002663	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1074485002664	substrate binding site [chemical binding]; other site
1074485002665	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1074485002666	active site
1074485002667	Ap6A binding site [chemical binding]; other site
1074485002668	nudix motif; other site
1074485002669	metal binding site [ion binding]; metal-binding site
1074485002670	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485002671	catalytic core [active]
1074485002672	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1074485002673	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1074485002674	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1074485002675	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1074485002676	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1074485002677	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074485002678	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1074485002679	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1074485002680	thiamine monophosphate kinase; Provisional; Region: PRK05731
1074485002681	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1074485002682	ATP binding site [chemical binding]; other site
1074485002683	dimerization interface [polypeptide binding]; other site
1074485002684	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1074485002685	ligand binding site [chemical binding]; other site
1074485002686	active site
1074485002687	UGI interface [polypeptide binding]; other site
1074485002688	catalytic site [active]
1074485002689	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1074485002690	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1074485002691	generic binding surface II; other site
1074485002692	ssDNA binding site; other site
1074485002693	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485002694	ATP binding site [chemical binding]; other site
1074485002695	putative Mg++ binding site [ion binding]; other site
1074485002696	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485002697	nucleotide binding region [chemical binding]; other site
1074485002698	ATP-binding site [chemical binding]; other site
1074485002699	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1074485002700	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074485002701	carboxyltransferase (CT) interaction site; other site
1074485002702	biotinylation site [posttranslational modification]; other site
1074485002703	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1074485002704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002705	S-adenosylmethionine binding site [chemical binding]; other site
1074485002706	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1074485002707	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1074485002708	active site
1074485002709	(T/H)XGH motif; other site
1074485002710	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074485002711	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1074485002712	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1074485002713	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1074485002714	Walker A/P-loop; other site
1074485002715	ATP binding site [chemical binding]; other site
1074485002716	Q-loop/lid; other site
1074485002717	ABC transporter signature motif; other site
1074485002718	Walker B; other site
1074485002719	D-loop; other site
1074485002720	H-loop/switch region; other site
1074485002721	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1074485002722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485002723	dimer interface [polypeptide binding]; other site
1074485002724	conserved gate region; other site
1074485002725	putative PBP binding loops; other site
1074485002726	ABC-ATPase subunit interface; other site
1074485002727	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074485002728	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1074485002729	substrate binding pocket [chemical binding]; other site
1074485002730	membrane-bound complex binding site; other site
1074485002731	hinge residues; other site
1074485002732	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1074485002733	DNA polymerase I; Provisional; Region: PRK05755
1074485002734	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1074485002735	active site
1074485002736	metal binding site 1 [ion binding]; metal-binding site
1074485002737	putative 5' ssDNA interaction site; other site
1074485002738	metal binding site 3; metal-binding site
1074485002739	metal binding site 2 [ion binding]; metal-binding site
1074485002740	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1074485002741	putative DNA binding site [nucleotide binding]; other site
1074485002742	putative metal binding site [ion binding]; other site
1074485002743	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1074485002744	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1074485002745	active site
1074485002746	DNA binding site [nucleotide binding]
1074485002747	catalytic site [active]
1074485002748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002749	S-adenosylmethionine binding site [chemical binding]; other site
1074485002750	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1074485002751	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1074485002752	RNA binding site [nucleotide binding]; other site
1074485002753	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1074485002754	RNA binding site [nucleotide binding]; other site
1074485002755	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1074485002756	RNA binding site [nucleotide binding]; other site
1074485002757	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1074485002758	RNA binding site [nucleotide binding]; other site
1074485002759	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1074485002760	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074485002761	active site turn [active]
1074485002762	phosphorylation site [posttranslational modification]
1074485002763	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074485002764	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1074485002765	HPr interaction site; other site
1074485002766	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074485002767	active site
1074485002768	phosphorylation site [posttranslational modification]
1074485002769	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1074485002770	ATP-binding [chemical binding]; other site
1074485002771	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1074485002772	CoA-binding site [chemical binding]; other site
1074485002773	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1074485002774	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485002775	FeS/SAM binding site; other site
1074485002776	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1074485002777	excinuclease ABC subunit B; Provisional; Region: PRK05298
1074485002778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485002779	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485002780	nucleotide binding region [chemical binding]; other site
1074485002781	ATP-binding site [chemical binding]; other site
1074485002782	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1074485002783	UvrB/uvrC motif; Region: UVR; pfam02151
1074485002784	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074485002785	Ligand Binding Site [chemical binding]; other site
1074485002786	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1074485002787	Part of AAA domain; Region: AAA_19; pfam13245
1074485002788	Family description; Region: UvrD_C_2; pfam13538
1074485002789	Predicted membrane protein [Function unknown]; Region: COG2259
1074485002790	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074485002791	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1074485002792	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074485002793	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074485002794	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1074485002795	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1074485002796	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1074485002797	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1074485002798	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1074485002799	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1074485002800	23S rRNA binding site [nucleotide binding]; other site
1074485002801	L21 binding site [polypeptide binding]; other site
1074485002802	L13 binding site [polypeptide binding]; other site
1074485002803	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074485002804	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1074485002805	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074485002806	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1074485002807	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1074485002808	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1074485002809	dimer interface [polypeptide binding]; other site
1074485002810	motif 1; other site
1074485002811	active site
1074485002812	motif 2; other site
1074485002813	motif 3; other site
1074485002814	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1074485002815	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1074485002816	putative tRNA-binding site [nucleotide binding]; other site
1074485002817	B3/4 domain; Region: B3_4; pfam03483
1074485002818	tRNA synthetase B5 domain; Region: B5; smart00874
1074485002819	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1074485002820	dimer interface [polypeptide binding]; other site
1074485002821	motif 1; other site
1074485002822	motif 3; other site
1074485002823	motif 2; other site
1074485002824	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1074485002825	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1074485002826	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1074485002827	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1074485002828	heterotetramer interface [polypeptide binding]; other site
1074485002829	active site pocket [active]
1074485002830	cleavage site
1074485002831	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1074485002832	feedback inhibition sensing region; other site
1074485002833	homohexameric interface [polypeptide binding]; other site
1074485002834	nucleotide binding site [chemical binding]; other site
1074485002835	N-acetyl-L-glutamate binding site [chemical binding]; other site
1074485002836	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1074485002837	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074485002838	inhibitor-cofactor binding pocket; inhibition site
1074485002839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485002840	catalytic residue [active]
1074485002841	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1074485002842	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074485002843	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074485002844	arginine repressor; Provisional; Region: PRK03341
1074485002845	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1074485002846	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1074485002847	argininosuccinate synthase; Provisional; Region: PRK13820
1074485002848	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1074485002849	ANP binding site [chemical binding]; other site
1074485002850	Substrate Binding Site II [chemical binding]; other site
1074485002851	Substrate Binding Site I [chemical binding]; other site
1074485002852	argininosuccinate lyase; Provisional; Region: PRK00855
1074485002853	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1074485002854	active sites [active]
1074485002855	tetramer interface [polypeptide binding]; other site
1074485002856	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1074485002857	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1074485002858	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1074485002859	active site
1074485002860	HIGH motif; other site
1074485002861	dimer interface [polypeptide binding]; other site
1074485002862	KMSKS motif; other site
1074485002863	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485002864	RNA binding surface [nucleotide binding]; other site
1074485002865	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1074485002866	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485002867	active site
1074485002868	motif I; other site
1074485002869	motif II; other site
1074485002870	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485002871	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1074485002872	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485002873	RNA binding surface [nucleotide binding]; other site
1074485002874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002875	S-adenosylmethionine binding site [chemical binding]; other site
1074485002876	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1074485002877	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1074485002878	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1074485002879	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1074485002880	Walker A/P-loop; other site
1074485002881	ATP binding site [chemical binding]; other site
1074485002882	Q-loop/lid; other site
1074485002883	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1074485002884	ABC transporter signature motif; other site
1074485002885	Walker B; other site
1074485002886	D-loop; other site
1074485002887	H-loop/switch region; other site
1074485002888	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1074485002889	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
1074485002890	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1074485002891	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1074485002892	dimer interface [polypeptide binding]; other site
1074485002893	ADP-ribose binding site [chemical binding]; other site
1074485002894	active site
1074485002895	nudix motif; other site
1074485002896	metal binding site [ion binding]; metal-binding site
1074485002897	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1074485002898	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1074485002899	active site
1074485002900	Int/Topo IB signature motif; other site
1074485002901	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1074485002902	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1074485002903	P-loop; other site
1074485002904	Magnesium ion binding site [ion binding]; other site
1074485002905	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1074485002906	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1074485002907	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1074485002908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485002909	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
1074485002910	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074485002911	inhibitor-cofactor binding pocket; inhibition site
1074485002912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485002913	catalytic residue [active]
1074485002914	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1074485002915	AAA domain; Region: AAA_26; pfam13500
1074485002916	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1074485002917	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1074485002918	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485002919	RNA binding surface [nucleotide binding]; other site
1074485002920	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1074485002921	active site
1074485002922	cytidylate kinase; Provisional; Region: cmk; PRK00023
1074485002923	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1074485002924	CMP-binding site; other site
1074485002925	The sites determining sugar specificity; other site
1074485002926	GTP-binding protein Der; Reviewed; Region: PRK03003
1074485002927	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1074485002928	G1 box; other site
1074485002929	GTP/Mg2+ binding site [chemical binding]; other site
1074485002930	Switch I region; other site
1074485002931	G2 box; other site
1074485002932	Switch II region; other site
1074485002933	G3 box; other site
1074485002934	G4 box; other site
1074485002935	G5 box; other site
1074485002936	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1074485002937	G1 box; other site
1074485002938	GTP/Mg2+ binding site [chemical binding]; other site
1074485002939	Switch I region; other site
1074485002940	G2 box; other site
1074485002941	G3 box; other site
1074485002942	Switch II region; other site
1074485002943	G4 box; other site
1074485002944	G5 box; other site
1074485002945	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1074485002946	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1074485002947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485002948	S-adenosylmethionine binding site [chemical binding]; other site
1074485002949	Putative esterase; Region: Esterase; pfam00756
1074485002950	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1074485002951	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1074485002952	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485002953	intersubunit interface [polypeptide binding]; other site
1074485002954	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485002955	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485002956	dimer interface [polypeptide binding]; other site
1074485002957	ABC-ATPase subunit  interface; other site
1074485002958	putative PBP binding regions; other site
1074485002959	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485002960	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485002961	ABC-ATPase subunit  interface; other site
1074485002962	dimer interface [polypeptide binding]; other site
1074485002963	putative PBP binding regions; other site
1074485002964	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074485002965	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485002966	Walker A/P-loop; other site
1074485002967	ATP binding site [chemical binding]; other site
1074485002968	Q-loop/lid; other site
1074485002969	ABC transporter signature motif; other site
1074485002970	Walker B; other site
1074485002971	D-loop; other site
1074485002972	H-loop/switch region; other site
1074485002973	IucA / IucC family; Region: IucA_IucC; pfam04183
1074485002974	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074485002975	IucA / IucC family; Region: IucA_IucC; pfam04183
1074485002976	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074485002977	H+ Antiporter protein; Region: 2A0121; TIGR00900
1074485002978	hypothetical protein; Provisional; Region: PRK01842
1074485002979	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1074485002980	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074485002981	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1074485002982	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074485002983	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1074485002984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485002985	nucleotide binding region [chemical binding]; other site
1074485002986	ATP-binding site [chemical binding]; other site
1074485002987	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1074485002988	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1074485002989	phosphopeptide binding site; other site
1074485002990	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1074485002991	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1074485002992	DNA binding residues [nucleotide binding]
1074485002993	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1074485002994	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1074485002995	DNA binding residues [nucleotide binding]
1074485002996	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1074485002997	putative dimer interface [polypeptide binding]; other site
1074485002998	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1074485002999	metal ion-dependent adhesion site (MIDAS); other site
1074485003000	Domain of unknown function DUF21; Region: DUF21; pfam01595
1074485003001	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1074485003002	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074485003003	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1074485003004	Domain of unknown function DUF21; Region: DUF21; pfam01595
1074485003005	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074485003006	Transporter associated domain; Region: CorC_HlyC; smart01091
1074485003007	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1074485003008	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074485003009	ATP binding site [chemical binding]; other site
1074485003010	putative Mg++ binding site [ion binding]; other site
1074485003011	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485003012	nucleotide binding region [chemical binding]; other site
1074485003013	ATP-binding site [chemical binding]; other site
1074485003014	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1074485003015	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1074485003016	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1074485003017	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1074485003018	CoenzymeA binding site [chemical binding]; other site
1074485003019	subunit interaction site [polypeptide binding]; other site
1074485003020	PHB binding site; other site
1074485003021	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1074485003022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485003023	S-adenosylmethionine binding site [chemical binding]; other site
1074485003024	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074485003025	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074485003026	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074485003027	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1074485003028	metabolite-proton symporter; Region: 2A0106; TIGR00883
1074485003029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485003030	putative substrate translocation pore; other site
1074485003031	YceI-like domain; Region: YceI; pfam04264
1074485003032	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1074485003033	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1074485003034	Ligand binding site; other site
1074485003035	Putative Catalytic site; other site
1074485003036	DXD motif; other site
1074485003037	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1074485003038	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1074485003039	putative active site [active]
1074485003040	catalytic triad [active]
1074485003041	putative dimer interface [polypeptide binding]; other site
1074485003042	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1074485003043	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1074485003044	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1074485003045	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1074485003046	precorrin-3B synthase; Region: CobG; TIGR02435
1074485003047	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1074485003048	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1074485003049	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1074485003050	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1074485003051	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1074485003052	active site
1074485003053	SAM binding site [chemical binding]; other site
1074485003054	homodimer interface [polypeptide binding]; other site
1074485003055	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1074485003056	active site
1074485003057	SAM binding site [chemical binding]; other site
1074485003058	homodimer interface [polypeptide binding]; other site
1074485003059	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1074485003060	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1074485003061	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
1074485003062	active site
1074485003063	SAM binding site [chemical binding]; other site
1074485003064	homodimer interface [polypeptide binding]; other site
1074485003065	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1074485003066	active site
1074485003067	putative homodimer interface [polypeptide binding]; other site
1074485003068	SAM binding site [chemical binding]; other site
1074485003069	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1074485003070	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
1074485003071	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1074485003072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485003073	NAD(P) binding site [chemical binding]; other site
1074485003074	active site
1074485003075	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1074485003076	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1074485003077	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1074485003078	active site
1074485003079	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1074485003080	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485003081	ATP binding site [chemical binding]; other site
1074485003082	putative Mg++ binding site [ion binding]; other site
1074485003083	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1074485003084	nucleotide binding region [chemical binding]; other site
1074485003085	ATP-binding site [chemical binding]; other site
1074485003086	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1074485003087	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1074485003088	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
1074485003089	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1074485003090	Predicted transcriptional regulator [Transcription]; Region: COG2378
1074485003091	WYL domain; Region: WYL; pfam13280
1074485003092	Predicted transcriptional regulator [Transcription]; Region: COG2378
1074485003093	WYL domain; Region: WYL; pfam13280
1074485003094	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1074485003095	Pup-like protein; Region: Pup; pfam05639
1074485003096	Pup-ligase protein; Region: Pup_ligase; cl15463
1074485003097	proteasome ATPase; Region: pup_AAA; TIGR03689
1074485003098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485003099	Walker A motif; other site
1074485003100	ATP binding site [chemical binding]; other site
1074485003101	Walker B motif; other site
1074485003102	arginine finger; other site
1074485003103	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1074485003104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1074485003105	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1074485003106	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1074485003107	active site
1074485003108	metal binding site [ion binding]; metal-binding site
1074485003109	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1074485003110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1074485003111	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1074485003112	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1074485003113	Potassium binding sites [ion binding]; other site
1074485003114	Cesium cation binding sites [ion binding]; other site
1074485003115	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1074485003116	Aspartase; Region: Aspartase; cd01357
1074485003117	active sites [active]
1074485003118	tetramer interface [polypeptide binding]; other site
1074485003119	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1074485003120	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1074485003121	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1074485003122	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1074485003123	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1074485003124	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1074485003125	homodimer interface [polypeptide binding]; other site
1074485003126	putative metal binding site [ion binding]; other site
1074485003127	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1074485003128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485003129	motif II; other site
1074485003130	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1074485003131	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1074485003132	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1074485003133	substrate binding pocket [chemical binding]; other site
1074485003134	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1074485003135	B12 binding site [chemical binding]; other site
1074485003136	cobalt ligand [ion binding]; other site
1074485003137	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1074485003138	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
1074485003139	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485003140	active site
1074485003141	HIGH motif; other site
1074485003142	nucleotide binding site [chemical binding]; other site
1074485003143	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485003144	active site
1074485003145	KMSKS motif; other site
1074485003146	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1074485003147	tRNA binding surface [nucleotide binding]; other site
1074485003148	anticodon binding site; other site
1074485003149	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1074485003150	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074485003151	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074485003152	active site
1074485003153	catalytic tetrad [active]
1074485003154	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1074485003155	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1074485003156	quinone interaction residues [chemical binding]; other site
1074485003157	active site
1074485003158	catalytic residues [active]
1074485003159	FMN binding site [chemical binding]; other site
1074485003160	substrate binding site [chemical binding]; other site
1074485003161	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1074485003162	substrate binding site [chemical binding]; other site
1074485003163	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1074485003164	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1074485003165	dimerization domain swap beta strand [polypeptide binding]; other site
1074485003166	regulatory protein interface [polypeptide binding]; other site
1074485003167	active site
1074485003168	regulatory phosphorylation site [posttranslational modification]; other site
1074485003169	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1074485003170	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1074485003171	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1074485003172	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074485003173	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1074485003174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485003175	NAD(P) binding site [chemical binding]; other site
1074485003176	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1074485003177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485003178	active site
1074485003179	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1074485003180	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1074485003181	Walker A; other site
1074485003182	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1074485003183	G4 box; other site
1074485003184	G5 box; other site
1074485003185	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1074485003186	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1074485003187	active site
1074485003188	substrate binding site [chemical binding]; other site
1074485003189	coenzyme B12 binding site [chemical binding]; other site
1074485003190	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1074485003191	B12 binding site [chemical binding]; other site
1074485003192	cobalt ligand [ion binding]; other site
1074485003193	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1074485003194	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1074485003195	heterodimer interface [polypeptide binding]; other site
1074485003196	substrate interaction site [chemical binding]; other site
1074485003197	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1074485003198	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1074485003199	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1074485003200	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1074485003201	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1074485003202	ferrochelatase; Reviewed; Region: hemH; PRK00035
1074485003203	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1074485003204	C-terminal domain interface [polypeptide binding]; other site
1074485003205	active site
1074485003206	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1074485003207	active site
1074485003208	N-terminal domain interface [polypeptide binding]; other site
1074485003209	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1074485003210	NlpC/P60 family; Region: NLPC_P60; pfam00877
1074485003211	pyruvate carboxylase subunit A; Validated; Region: PRK07178
1074485003212	aconitate hydratase; Validated; Region: PRK09277
1074485003213	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1074485003214	substrate binding site [chemical binding]; other site
1074485003215	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1074485003216	ligand binding site [chemical binding]; other site
1074485003217	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1074485003218	substrate binding site [chemical binding]; other site
1074485003219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485003220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485003221	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1074485003222	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128
1074485003223	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1074485003224	catalytic triad [active]
1074485003225	conserved cys residue [active]
1074485003226	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1074485003227	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1074485003228	AAA ATPase domain; Region: AAA_16; pfam13191
1074485003229	AAA domain; Region: AAA_22; pfam13401
1074485003230	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1074485003231	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074485003232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485003233	Walker A/P-loop; other site
1074485003234	ATP binding site [chemical binding]; other site
1074485003235	Q-loop/lid; other site
1074485003236	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074485003237	ABC transporter signature motif; other site
1074485003238	Walker B; other site
1074485003239	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074485003240	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1074485003241	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1074485003242	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1074485003243	trimerization site [polypeptide binding]; other site
1074485003244	active site
1074485003245	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1074485003246	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1074485003247	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074485003248	catalytic residue [active]
1074485003249	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1074485003250	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1074485003251	Walker A/P-loop; other site
1074485003252	ATP binding site [chemical binding]; other site
1074485003253	Q-loop/lid; other site
1074485003254	ABC transporter signature motif; other site
1074485003255	Walker B; other site
1074485003256	D-loop; other site
1074485003257	H-loop/switch region; other site
1074485003258	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1074485003259	FeS assembly protein SufD; Region: sufD; TIGR01981
1074485003260	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1074485003261	FeS assembly protein SufB; Region: sufB; TIGR01980
1074485003262	Predicted transcriptional regulator [Transcription]; Region: COG2345
1074485003263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1074485003264	putative DNA binding site [nucleotide binding]; other site
1074485003265	putative Zn2+ binding site [ion binding]; other site
1074485003266	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1074485003267	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074485003268	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074485003269	Walker A/P-loop; other site
1074485003270	ATP binding site [chemical binding]; other site
1074485003271	Q-loop/lid; other site
1074485003272	ABC transporter signature motif; other site
1074485003273	Walker B; other site
1074485003274	D-loop; other site
1074485003275	H-loop/switch region; other site
1074485003276	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1074485003277	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1074485003278	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1074485003279	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1074485003280	UbiA prenyltransferase family; Region: UbiA; pfam01040
1074485003281	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1074485003282	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1074485003283	TPP-binding site [chemical binding]; other site
1074485003284	dimer interface [polypeptide binding]; other site
1074485003285	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1074485003286	PYR/PP interface [polypeptide binding]; other site
1074485003287	dimer interface [polypeptide binding]; other site
1074485003288	TPP binding site [chemical binding]; other site
1074485003289	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074485003290	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1074485003291	putative active site [active]
1074485003292	transaldolase; Provisional; Region: PRK03903
1074485003293	catalytic residue [active]
1074485003294	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1074485003295	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1074485003296	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1074485003297	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1074485003298	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
1074485003299	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1074485003300	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1074485003301	putative active site [active]
1074485003302	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1074485003303	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1074485003304	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1074485003305	triosephosphate isomerase; Provisional; Region: PRK14567
1074485003306	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1074485003307	substrate binding site [chemical binding]; other site
1074485003308	dimer interface [polypeptide binding]; other site
1074485003309	catalytic triad [active]
1074485003310	Phosphoglycerate kinase; Region: PGK; pfam00162
1074485003311	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1074485003312	substrate binding site [chemical binding]; other site
1074485003313	hinge regions; other site
1074485003314	ADP binding site [chemical binding]; other site
1074485003315	catalytic site [active]
1074485003316	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1074485003317	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1074485003318	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074485003319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1074485003320	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1074485003321	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1074485003322	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1074485003323	phosphate binding site [ion binding]; other site
1074485003324	putative substrate binding pocket [chemical binding]; other site
1074485003325	dimer interface [polypeptide binding]; other site
1074485003326	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1074485003327	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1074485003328	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1074485003329	GIY-YIG motif/motif A; other site
1074485003330	active site
1074485003331	catalytic site [active]
1074485003332	putative DNA binding site [nucleotide binding]; other site
1074485003333	metal binding site [ion binding]; metal-binding site
1074485003334	UvrB/uvrC motif; Region: UVR; pfam02151
1074485003335	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1074485003336	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1074485003337	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1074485003338	homopentamer interface [polypeptide binding]; other site
1074485003339	active site
1074485003340	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1074485003341	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1074485003342	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1074485003343	dimerization interface [polypeptide binding]; other site
1074485003344	active site
1074485003345	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1074485003346	Lumazine binding domain; Region: Lum_binding; pfam00677
1074485003347	Lumazine binding domain; Region: Lum_binding; pfam00677
1074485003348	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1074485003349	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1074485003350	catalytic motif [active]
1074485003351	Zn binding site [ion binding]; other site
1074485003352	RibD C-terminal domain; Region: RibD_C; pfam01872
1074485003353	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1074485003354	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1074485003355	substrate binding site [chemical binding]; other site
1074485003356	hexamer interface [polypeptide binding]; other site
1074485003357	metal binding site [ion binding]; metal-binding site
1074485003358	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1074485003359	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1074485003360	putative RNA binding site [nucleotide binding]; other site
1074485003361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485003362	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1074485003363	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1074485003364	putative active site [active]
1074485003365	substrate binding site [chemical binding]; other site
1074485003366	putative cosubstrate binding site; other site
1074485003367	catalytic site [active]
1074485003368	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1074485003369	substrate binding site [chemical binding]; other site
1074485003370	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1074485003371	active site
1074485003372	catalytic residues [active]
1074485003373	metal binding site [ion binding]; metal-binding site
1074485003374	primosome assembly protein PriA; Provisional; Region: PRK14873
1074485003375	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1074485003376	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1074485003377	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1074485003378	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1074485003379	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1074485003380	Flavoprotein; Region: Flavoprotein; pfam02441
1074485003381	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1074485003382	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1074485003383	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1074485003384	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1074485003385	catalytic site [active]
1074485003386	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1074485003387	active site
1074485003388	dimer interface [polypeptide binding]; other site
1074485003389	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1074485003390	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074485003391	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074485003392	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1074485003393	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074485003394	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074485003395	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1074485003396	IMP binding site; other site
1074485003397	dimer interface [polypeptide binding]; other site
1074485003398	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1074485003399	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1074485003400	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1074485003401	catalytic site [active]
1074485003402	subunit interface [polypeptide binding]; other site
1074485003403	dihydroorotase; Validated; Region: pyrC; PRK09357
1074485003404	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1074485003405	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1074485003406	active site
1074485003407	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1074485003408	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074485003409	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074485003410	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1074485003411	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485003412	active site
1074485003413	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1074485003414	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1074485003415	putative RNA binding site [nucleotide binding]; other site
1074485003416	elongation factor P; Validated; Region: PRK00529
1074485003417	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1074485003418	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1074485003419	RNA binding site [nucleotide binding]; other site
1074485003420	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1074485003421	RNA binding site [nucleotide binding]; other site
1074485003422	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1074485003423	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1074485003424	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1074485003425	active site
1074485003426	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1074485003427	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1074485003428	trimer interface [polypeptide binding]; other site
1074485003429	active site
1074485003430	dimer interface [polypeptide binding]; other site
1074485003431	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1074485003432	active site
1074485003433	dimer interface [polypeptide binding]; other site
1074485003434	metal binding site [ion binding]; metal-binding site
1074485003435	shikimate kinase; Reviewed; Region: aroK; PRK00131
1074485003436	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1074485003437	ADP binding site [chemical binding]; other site
1074485003438	magnesium binding site [ion binding]; other site
1074485003439	putative shikimate binding site; other site
1074485003440	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1074485003441	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1074485003442	Tetramer interface [polypeptide binding]; other site
1074485003443	active site
1074485003444	FMN-binding site [chemical binding]; other site
1074485003445	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1074485003446	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1074485003447	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1074485003448	shikimate binding site; other site
1074485003449	NAD(P) binding site [chemical binding]; other site
1074485003450	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1074485003451	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1074485003452	dimerization interface [polypeptide binding]; other site
1074485003453	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1074485003454	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1074485003455	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1074485003456	motif 1; other site
1074485003457	active site
1074485003458	motif 2; other site
1074485003459	motif 3; other site
1074485003460	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1074485003461	DHHA1 domain; Region: DHHA1; pfam02272
1074485003462	recombination factor protein RarA; Reviewed; Region: PRK13342
1074485003463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485003464	Walker A motif; other site
1074485003465	ATP binding site [chemical binding]; other site
1074485003466	Walker B motif; other site
1074485003467	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1074485003468	Phosphotransferase enzyme family; Region: APH; pfam01636
1074485003469	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1074485003470	substrate binding site [chemical binding]; other site
1074485003471	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1074485003472	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1074485003473	dimer interface [polypeptide binding]; other site
1074485003474	anticodon binding site; other site
1074485003475	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1074485003476	homodimer interface [polypeptide binding]; other site
1074485003477	motif 1; other site
1074485003478	active site
1074485003479	motif 2; other site
1074485003480	GAD domain; Region: GAD; pfam02938
1074485003481	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074485003482	active site
1074485003483	motif 3; other site
1074485003484	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1074485003485	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1074485003486	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485003487	ATP binding site [chemical binding]; other site
1074485003488	putative Mg++ binding site [ion binding]; other site
1074485003489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485003490	nucleotide binding region [chemical binding]; other site
1074485003491	ATP-binding site [chemical binding]; other site
1074485003492	Predicted membrane protein [Function unknown]; Region: COG1511
1074485003493	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1074485003494	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1074485003495	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1074485003496	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1074485003497	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
1074485003498	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485003499	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485003500	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074485003501	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1074485003502	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1074485003503	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1074485003504	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1074485003505	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1074485003506	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1074485003507	putative active site [active]
1074485003508	putative catalytic site [active]
1074485003509	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1074485003510	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1074485003511	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1074485003512	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1074485003513	dimer interface [polypeptide binding]; other site
1074485003514	motif 1; other site
1074485003515	active site
1074485003516	motif 2; other site
1074485003517	motif 3; other site
1074485003518	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1074485003519	anticodon binding site; other site
1074485003520	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074485003521	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1074485003522	dimer interface [polypeptide binding]; other site
1074485003523	catalytic triad [active]
1074485003524	peroxidatic and resolving cysteines [active]
1074485003525	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1074485003526	active site
1074485003527	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1074485003528	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074485003529	Zn2+ binding site [ion binding]; other site
1074485003530	Mg2+ binding site [ion binding]; other site
1074485003531	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074485003532	synthetase active site [active]
1074485003533	NTP binding site [chemical binding]; other site
1074485003534	metal binding site [ion binding]; metal-binding site
1074485003535	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1074485003536	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1074485003537	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485003538	active site
1074485003539	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074485003540	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1074485003541	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1074485003542	Protein export membrane protein; Region: SecD_SecF; pfam02355
1074485003543	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
1074485003544	Protein export membrane protein; Region: SecD_SecF; cl14618
1074485003545	Preprotein translocase subunit; Region: YajC; pfam02699
1074485003546	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1074485003547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485003548	Walker A motif; other site
1074485003549	ATP binding site [chemical binding]; other site
1074485003550	Walker B motif; other site
1074485003551	arginine finger; other site
1074485003552	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1074485003553	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1074485003554	RuvA N terminal domain; Region: RuvA_N; pfam01330
1074485003555	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1074485003556	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1074485003557	active site
1074485003558	putative DNA-binding cleft [nucleotide binding]; other site
1074485003559	dimer interface [polypeptide binding]; other site
1074485003560	hypothetical protein; Validated; Region: PRK00110
1074485003561	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1074485003562	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1074485003563	active site
1074485003564	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1074485003565	catalytic triad [active]
1074485003566	dimer interface [polypeptide binding]; other site
1074485003567	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1074485003568	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
1074485003569	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1074485003570	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1074485003571	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074485003572	catalytic residue [active]
1074485003573	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074485003574	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1074485003575	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1074485003576	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1074485003577	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1074485003578	putative acyl-acceptor binding pocket; other site
1074485003579	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1074485003580	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1074485003581	nucleotide binding site/active site [active]
1074485003582	HIT family signature motif; other site
1074485003583	catalytic residue [active]
1074485003584	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1074485003585	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1074485003586	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1074485003587	active site
1074485003588	dimer interface [polypeptide binding]; other site
1074485003589	motif 1; other site
1074485003590	motif 2; other site
1074485003591	motif 3; other site
1074485003592	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1074485003593	anticodon binding site; other site
1074485003594	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1074485003595	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1074485003596	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1074485003597	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1074485003598	hypothetical protein; Provisional; Region: PRK14059
1074485003599	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1074485003600	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1074485003601	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1074485003602	SelR domain; Region: SelR; pfam01641
1074485003603	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1074485003604	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1074485003605	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1074485003606	catalytic site [active]
1074485003607	putative active site [active]
1074485003608	putative substrate binding site [chemical binding]; other site
1074485003609	HRDC domain; Region: HRDC; pfam00570
1074485003610	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1074485003611	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1074485003612	TPP-binding site; other site
1074485003613	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1074485003614	PYR/PP interface [polypeptide binding]; other site
1074485003615	dimer interface [polypeptide binding]; other site
1074485003616	TPP binding site [chemical binding]; other site
1074485003617	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074485003618	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1074485003619	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1074485003620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485003621	S-adenosylmethionine binding site [chemical binding]; other site
1074485003622	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1074485003623	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1074485003624	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1074485003625	trimer interface [polypeptide binding]; other site
1074485003626	active site
1074485003627	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1074485003628	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1074485003629	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074485003630	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1074485003631	active site
1074485003632	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1074485003633	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1074485003634	nucleotide binding site [chemical binding]; other site
1074485003635	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1074485003636	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1074485003637	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485003638	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1074485003639	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485003640	DNA binding residues [nucleotide binding]
1074485003641	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1074485003642	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1074485003643	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1074485003644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485003645	S-adenosylmethionine binding site [chemical binding]; other site
1074485003646	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1074485003647	putative active site [active]
1074485003648	dimerization interface [polypeptide binding]; other site
1074485003649	putative tRNAtyr binding site [nucleotide binding]; other site
1074485003650	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1074485003651	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1074485003652	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485003653	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1074485003654	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485003655	DNA binding residues [nucleotide binding]
1074485003656	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1074485003657	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1074485003658	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1074485003659	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1074485003660	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1074485003661	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1074485003662	NAD binding site [chemical binding]; other site
1074485003663	homodimer interface [polypeptide binding]; other site
1074485003664	active site
1074485003665	substrate binding site [chemical binding]; other site
1074485003666	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1074485003667	PAC2 family; Region: PAC2; pfam09754
1074485003668	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1074485003669	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485003670	ATP binding site [chemical binding]; other site
1074485003671	putative Mg++ binding site [ion binding]; other site
1074485003672	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485003673	nucleotide binding region [chemical binding]; other site
1074485003674	ATP-binding site [chemical binding]; other site
1074485003675	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
1074485003676	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1074485003677	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1074485003678	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1074485003679	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1074485003680	dimer interface [polypeptide binding]; other site
1074485003681	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1074485003682	catalytic triad [active]
1074485003683	peroxidatic and resolving cysteines [active]
1074485003684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074485003685	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1074485003686	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1074485003687	dimerization interface [polypeptide binding]; other site
1074485003688	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1074485003689	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1074485003690	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485003691	ATP binding site [chemical binding]; other site
1074485003692	putative Mg++ binding site [ion binding]; other site
1074485003693	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074485003694	nucleotide binding region [chemical binding]; other site
1074485003695	ATP-binding site [chemical binding]; other site
1074485003696	Helicase associated domain (HA2); Region: HA2; pfam04408
1074485003697	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1074485003698	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1074485003699	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1074485003700	ATP cone domain; Region: ATP-cone; pfam03477
1074485003701	LexA repressor; Validated; Region: PRK00215
1074485003702	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1074485003703	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1074485003704	Catalytic site [active]
1074485003705	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074485003706	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1074485003707	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074485003708	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1074485003709	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1074485003710	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1074485003711	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1074485003712	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074485003713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074485003714	DNA-binding site [nucleotide binding]; DNA binding site
1074485003715	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074485003716	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1074485003717	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1074485003718	putative substrate binding site [chemical binding]; other site
1074485003719	putative ATP binding site [chemical binding]; other site
1074485003720	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074485003721	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1074485003722	active site
1074485003723	phosphorylation site [posttranslational modification]
1074485003724	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1074485003725	active site
1074485003726	P-loop; other site
1074485003727	phosphorylation site [posttranslational modification]
1074485003728	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074485003729	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1074485003730	dimerization domain swap beta strand [polypeptide binding]; other site
1074485003731	regulatory protein interface [polypeptide binding]; other site
1074485003732	active site
1074485003733	regulatory phosphorylation site [posttranslational modification]; other site
1074485003734	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1074485003735	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1074485003736	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074485003737	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1074485003738	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1074485003739	GTPases [General function prediction only]; Region: HflX; COG2262
1074485003740	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1074485003741	HflX GTPase family; Region: HflX; cd01878
1074485003742	G1 box; other site
1074485003743	GTP/Mg2+ binding site [chemical binding]; other site
1074485003744	Switch I region; other site
1074485003745	G2 box; other site
1074485003746	G3 box; other site
1074485003747	Switch II region; other site
1074485003748	G4 box; other site
1074485003749	G5 box; other site
1074485003750	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1074485003751	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1074485003752	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1074485003753	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1074485003754	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1074485003755	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1074485003756	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1074485003757	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1074485003758	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
1074485003759	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1074485003760	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1074485003761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485003762	FeS/SAM binding site; other site
1074485003763	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1074485003764	recombinase A; Provisional; Region: recA; PRK09354
1074485003765	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1074485003766	hexamer interface [polypeptide binding]; other site
1074485003767	Walker A motif; other site
1074485003768	ATP binding site [chemical binding]; other site
1074485003769	Walker B motif; other site
1074485003770	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1074485003771	BioY family; Region: BioY; pfam02632
1074485003772	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074485003773	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074485003774	Walker A/P-loop; other site
1074485003775	ATP binding site [chemical binding]; other site
1074485003776	Q-loop/lid; other site
1074485003777	ABC transporter signature motif; other site
1074485003778	Walker B; other site
1074485003779	D-loop; other site
1074485003780	H-loop/switch region; other site
1074485003781	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074485003782	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1074485003783	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074485003784	sequence-specific DNA binding site [nucleotide binding]; other site
1074485003785	salt bridge; other site
1074485003786	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1074485003787	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1074485003788	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1074485003789	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1074485003790	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074485003791	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1074485003792	TIGR03085 family protein; Region: TIGR03085
1074485003793	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1074485003794	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074485003795	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1074485003796	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1074485003797	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1074485003798	dimer interface [polypeptide binding]; other site
1074485003799	active site
1074485003800	catalytic residue [active]
1074485003801	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1074485003802	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1074485003803	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1074485003804	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1074485003805	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1074485003806	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1074485003807	oligomer interface [polypeptide binding]; other site
1074485003808	RNA binding site [nucleotide binding]; other site
1074485003809	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1074485003810	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1074485003811	RNase E interface [polypeptide binding]; other site
1074485003812	trimer interface [polypeptide binding]; other site
1074485003813	active site
1074485003814	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1074485003815	putative nucleic acid binding region [nucleotide binding]; other site
1074485003816	G-X-X-G motif; other site
1074485003817	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1074485003818	RNA binding site [nucleotide binding]; other site
1074485003819	domain interface; other site
1074485003820	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1074485003821	16S/18S rRNA binding site [nucleotide binding]; other site
1074485003822	S13e-L30e interaction site [polypeptide binding]; other site
1074485003823	25S rRNA binding site [nucleotide binding]; other site
1074485003824	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1074485003825	active site
1074485003826	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1074485003827	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1074485003828	active site
1074485003829	Riboflavin kinase; Region: Flavokinase; smart00904
1074485003830	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1074485003831	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1074485003832	RNA binding site [nucleotide binding]; other site
1074485003833	active site
1074485003834	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1074485003835	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1074485003836	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1074485003837	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1074485003838	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1074485003839	active site
1074485003840	metal binding site [ion binding]; metal-binding site
1074485003841	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1074485003842	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1074485003843	DHH family; Region: DHH; pfam01368
1074485003844	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1074485003845	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1074485003846	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074485003847	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074485003848	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1074485003849	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1074485003850	G1 box; other site
1074485003851	putative GEF interaction site [polypeptide binding]; other site
1074485003852	GTP/Mg2+ binding site [chemical binding]; other site
1074485003853	Switch I region; other site
1074485003854	G2 box; other site
1074485003855	G3 box; other site
1074485003856	Switch II region; other site
1074485003857	G4 box; other site
1074485003858	G5 box; other site
1074485003859	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1074485003860	Translation-initiation factor 2; Region: IF-2; pfam11987
1074485003861	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1074485003862	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1074485003863	putative RNA binding cleft [nucleotide binding]; other site
1074485003864	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1074485003865	NusA N-terminal domain; Region: NusA_N; pfam08529
1074485003866	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1074485003867	RNA binding site [nucleotide binding]; other site
1074485003868	homodimer interface [polypeptide binding]; other site
1074485003869	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1074485003870	G-X-X-G motif; other site
1074485003871	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1074485003872	G-X-X-G motif; other site
1074485003873	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1074485003874	Sm and related proteins; Region: Sm_like; cl00259
1074485003875	heptamer interface [polypeptide binding]; other site
1074485003876	Sm1 motif; other site
1074485003877	hexamer interface [polypeptide binding]; other site
1074485003878	RNA binding site [nucleotide binding]; other site
1074485003879	Sm2 motif; other site
1074485003880	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1074485003881	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1074485003882	dimer interface [polypeptide binding]; other site
1074485003883	motif 1; other site
1074485003884	active site
1074485003885	motif 2; other site
1074485003886	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1074485003887	putative deacylase active site [active]
1074485003888	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074485003889	active site
1074485003890	motif 3; other site
1074485003891	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1074485003892	anticodon binding site; other site
1074485003893	hypothetical protein; Validated; Region: PRK02101
1074485003894	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1074485003895	active site
1074485003896	SAM binding site [chemical binding]; other site
1074485003897	homodimer interface [polypeptide binding]; other site
1074485003898	hypothetical protein; Validated; Region: PRK00029
1074485003899	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1074485003900	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074485003901	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074485003902	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1074485003903	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1074485003904	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1074485003905	DNA binding site [nucleotide binding]
1074485003906	active site
1074485003907	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1074485003908	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1074485003909	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1074485003910	catalytic triad [active]
1074485003911	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1074485003912	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1074485003913	homodimer interface [polypeptide binding]; other site
1074485003914	Walker A motif; other site
1074485003915	ATP binding site [chemical binding]; other site
1074485003916	hydroxycobalamin binding site [chemical binding]; other site
1074485003917	Walker B motif; other site
1074485003918	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
1074485003919	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1074485003920	metal ion-dependent adhesion site (MIDAS); other site
1074485003921	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1074485003922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485003923	Walker A motif; other site
1074485003924	ATP binding site [chemical binding]; other site
1074485003925	Walker B motif; other site
1074485003926	arginine finger; other site
1074485003927	malate:quinone oxidoreductase; Validated; Region: PRK05257
1074485003928	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1074485003929	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1074485003930	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074485003931	mycothione reductase; Reviewed; Region: PRK07846
1074485003932	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074485003933	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074485003934	cobyric acid synthase; Provisional; Region: PRK00784
1074485003935	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074485003936	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1074485003937	catalytic triad [active]
1074485003938	methionine aminopeptidase; Provisional; Region: PRK12318
1074485003939	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1074485003940	active site
1074485003941	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1074485003942	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074485003943	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1074485003944	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1074485003945	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1074485003946	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1074485003947	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1074485003948	active site
1074485003949	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1074485003950	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1074485003951	putative substrate binding region [chemical binding]; other site
1074485003952	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1074485003953	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1074485003954	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1074485003955	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1074485003956	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1074485003957	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1074485003958	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485003959	FeS/SAM binding site; other site
1074485003960	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1074485003961	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1074485003962	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1074485003963	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1074485003964	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1074485003965	hinge region; other site
1074485003966	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1074485003967	putative nucleotide binding site [chemical binding]; other site
1074485003968	uridine monophosphate binding site [chemical binding]; other site
1074485003969	homohexameric interface [polypeptide binding]; other site
1074485003970	elongation factor Ts; Provisional; Region: tsf; PRK09377
1074485003971	UBA/TS-N domain; Region: UBA; pfam00627
1074485003972	Elongation factor TS; Region: EF_TS; pfam00889
1074485003973	Elongation factor TS; Region: EF_TS; pfam00889
1074485003974	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1074485003975	rRNA interaction site [nucleotide binding]; other site
1074485003976	S8 interaction site; other site
1074485003977	putative laminin-1 binding site; other site
1074485003978	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074485003979	Peptidase family M23; Region: Peptidase_M23; pfam01551
1074485003980	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1074485003981	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074485003982	active site
1074485003983	DNA binding site [nucleotide binding]
1074485003984	Int/Topo IB signature motif; other site
1074485003985	hypothetical protein; Reviewed; Region: PRK12497
1074485003986	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1074485003987	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1074485003988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485003989	Walker A motif; other site
1074485003990	ATP binding site [chemical binding]; other site
1074485003991	Walker B motif; other site
1074485003992	arginine finger; other site
1074485003993	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1074485003994	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1074485003995	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1074485003996	RNA/DNA hybrid binding site [nucleotide binding]; other site
1074485003997	active site
1074485003998	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1074485003999	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1074485004000	Catalytic site [active]
1074485004001	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1074485004002	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1074485004003	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1074485004004	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1074485004005	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1074485004006	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1074485004007	RNA binding site [nucleotide binding]; other site
1074485004008	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1074485004009	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1074485004010	active site
1074485004011	P-loop; other site
1074485004012	phosphorylation site [posttranslational modification]
1074485004013	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074485004014	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074485004015	active site
1074485004016	phosphorylation site [posttranslational modification]
1074485004017	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1074485004018	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1074485004019	RimM N-terminal domain; Region: RimM; pfam01782
1074485004020	PRC-barrel domain; Region: PRC; pfam05239
1074485004021	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1074485004022	signal recognition particle protein; Provisional; Region: PRK10867
1074485004023	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1074485004024	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1074485004025	P loop; other site
1074485004026	GTP binding site [chemical binding]; other site
1074485004027	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1074485004028	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
1074485004029	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1074485004030	metal binding triad; other site
1074485004031	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1074485004032	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074485004033	Zn2+ binding site [ion binding]; other site
1074485004034	Mg2+ binding site [ion binding]; other site
1074485004035	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1074485004036	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1074485004037	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1074485004038	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1074485004039	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074485004040	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1074485004041	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1074485004042	Walker A/P-loop; other site
1074485004043	ATP binding site [chemical binding]; other site
1074485004044	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
1074485004045	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1074485004046	ABC transporter signature motif; other site
1074485004047	Walker B; other site
1074485004048	D-loop; other site
1074485004049	H-loop/switch region; other site
1074485004050	Acylphosphatase; Region: Acylphosphatase; cl00551
1074485004051	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1074485004052	amino acid carrier protein; Region: agcS; TIGR00835
1074485004053	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1074485004054	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1074485004055	DNA binding site [nucleotide binding]
1074485004056	catalytic residue [active]
1074485004057	H2TH interface [polypeptide binding]; other site
1074485004058	putative catalytic residues [active]
1074485004059	turnover-facilitating residue; other site
1074485004060	intercalation triad [nucleotide binding]; other site
1074485004061	8OG recognition residue [nucleotide binding]; other site
1074485004062	putative reading head residues; other site
1074485004063	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1074485004064	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1074485004065	ribonuclease III; Reviewed; Region: rnc; PRK00102
1074485004066	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1074485004067	dimerization interface [polypeptide binding]; other site
1074485004068	active site
1074485004069	metal binding site [ion binding]; metal-binding site
1074485004070	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1074485004071	dsRNA binding site [nucleotide binding]; other site
1074485004072	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1074485004073	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1074485004074	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1074485004075	RibD C-terminal domain; Region: RibD_C; cl17279
1074485004076	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1074485004077	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1074485004078	hexamer interface [polypeptide binding]; other site
1074485004079	ligand binding site [chemical binding]; other site
1074485004080	putative active site [active]
1074485004081	NAD(P) binding site [chemical binding]; other site
1074485004082	glutamate dehydrogenase; Provisional; Region: PRK09414
1074485004083	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1074485004084	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1074485004085	NAD(P) binding site [chemical binding]; other site
1074485004086	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1074485004087	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1074485004088	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1074485004089	nucleotide binding site/active site [active]
1074485004090	HIT family signature motif; other site
1074485004091	catalytic residue [active]
1074485004092	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1074485004093	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074485004094	metal binding site [ion binding]; metal-binding site
1074485004095	putative dimer interface [polypeptide binding]; other site
1074485004096	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1074485004097	homodimer interface [polypeptide binding]; other site
1074485004098	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1074485004099	active site pocket [active]
1074485004100	Electron transfer DM13; Region: DM13; pfam10517
1074485004101	pyruvate kinase; Provisional; Region: PRK06247
1074485004102	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1074485004103	domain interfaces; other site
1074485004104	active site
1074485004105	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1074485004106	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1074485004107	active site
1074485004108	ribulose/triose binding site [chemical binding]; other site
1074485004109	phosphate binding site [ion binding]; other site
1074485004110	substrate (anthranilate) binding pocket [chemical binding]; other site
1074485004111	product (indole) binding pocket [chemical binding]; other site
1074485004112	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1074485004113	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1074485004114	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1074485004115	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1074485004116	substrate binding site [chemical binding]; other site
1074485004117	glutamase interaction surface [polypeptide binding]; other site
1074485004118	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1074485004119	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074485004120	active site
1074485004121	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1074485004122	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1074485004123	catalytic residues [active]
1074485004124	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1074485004125	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1074485004126	putative active site [active]
1074485004127	oxyanion strand; other site
1074485004128	catalytic triad [active]
1074485004129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485004130	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074485004131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485004132	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1074485004133	putative active site pocket [active]
1074485004134	4-fold oligomerization interface [polypeptide binding]; other site
1074485004135	metal binding residues [ion binding]; metal-binding site
1074485004136	3-fold/trimer interface [polypeptide binding]; other site
1074485004137	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1074485004138	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485004139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004140	homodimer interface [polypeptide binding]; other site
1074485004141	catalytic residue [active]
1074485004142	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1074485004143	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1074485004144	NAD binding site [chemical binding]; other site
1074485004145	dimerization interface [polypeptide binding]; other site
1074485004146	product binding site; other site
1074485004147	substrate binding site [chemical binding]; other site
1074485004148	zinc binding site [ion binding]; other site
1074485004149	catalytic residues [active]
1074485004150	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1074485004151	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1074485004152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485004153	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1074485004154	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1074485004155	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1074485004156	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1074485004157	active site
1074485004158	catalytic site [active]
1074485004159	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
1074485004160	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1074485004161	active site
1074485004162	catalytic site [active]
1074485004163	substrate binding site [chemical binding]; other site
1074485004164	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1074485004165	Dimer interface [polypeptide binding]; other site
1074485004166	BRCT sequence motif; other site
1074485004167	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074485004168	synthetase active site [active]
1074485004169	NTP binding site [chemical binding]; other site
1074485004170	metal binding site [ion binding]; metal-binding site
1074485004171	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485004172	RNA binding surface [nucleotide binding]; other site
1074485004173	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1074485004174	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1074485004175	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1074485004176	threonine dehydratase; Validated; Region: PRK08639
1074485004177	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1074485004178	tetramer interface [polypeptide binding]; other site
1074485004179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004180	catalytic residue [active]
1074485004181	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1074485004182	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1074485004183	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1074485004184	active site
1074485004185	PHP Thumb interface [polypeptide binding]; other site
1074485004186	metal binding site [ion binding]; metal-binding site
1074485004187	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1074485004188	generic binding surface I; other site
1074485004189	generic binding surface II; other site
1074485004190	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1074485004191	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074485004192	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074485004193	RNA binding surface [nucleotide binding]; other site
1074485004194	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074485004195	active site
1074485004196	lipoprotein signal peptidase; Provisional; Region: PRK14764
1074485004197	lipoprotein signal peptidase; Provisional; Region: PRK14787
1074485004198	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1074485004199	active site
1074485004200	homotetramer interface [polypeptide binding]; other site
1074485004201	homodimer interface [polypeptide binding]; other site
1074485004202	DNA polymerase IV; Provisional; Region: PRK03348
1074485004203	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1074485004204	active site
1074485004205	DNA binding site [nucleotide binding]
1074485004206	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1074485004207	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1074485004208	HIGH motif; other site
1074485004209	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1074485004210	active site
1074485004211	KMSKS motif; other site
1074485004212	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1074485004213	tRNA binding surface [nucleotide binding]; other site
1074485004214	anticodon binding site; other site
1074485004215	DivIVA protein; Region: DivIVA; pfam05103
1074485004216	DivIVA domain; Region: DivI1A_domain; TIGR03544
1074485004217	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1074485004218	YGGT family; Region: YGGT; pfam02325
1074485004219	Protein of unknown function (DUF552); Region: DUF552; cl00775
1074485004220	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1074485004221	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1074485004222	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
1074485004223	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1074485004224	nucleotide binding site [chemical binding]; other site
1074485004225	SulA interaction site; other site
1074485004226	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1074485004227	Cell division protein FtsQ; Region: FtsQ; pfam03799
1074485004228	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1074485004229	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074485004230	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485004231	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074485004232	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1074485004233	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1074485004234	homodimer interface [polypeptide binding]; other site
1074485004235	active site
1074485004236	cell division protein FtsW; Region: ftsW; TIGR02614
1074485004237	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
1074485004238	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485004239	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1074485004240	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1074485004241	Mg++ binding site [ion binding]; other site
1074485004242	putative catalytic motif [active]
1074485004243	putative substrate binding site [chemical binding]; other site
1074485004244	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1074485004245	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074485004246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485004247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074485004248	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1074485004249	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074485004250	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485004251	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074485004252	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074485004253	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1074485004254	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074485004255	MraW methylase family; Region: Methyltransf_5; cl17771
1074485004256	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1074485004257	cell division protein MraZ; Reviewed; Region: PRK00326
1074485004258	MraZ protein; Region: MraZ; pfam02381
1074485004259	MraZ protein; Region: MraZ; pfam02381
1074485004260	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1074485004261	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074485004262	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1074485004263	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1074485004264	FAD binding site [chemical binding]; other site
1074485004265	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1074485004266	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1074485004267	substrate binding pocket [chemical binding]; other site
1074485004268	chain length determination region; other site
1074485004269	substrate-Mg2+ binding site; other site
1074485004270	catalytic residues [active]
1074485004271	aspartate-rich region 1; other site
1074485004272	active site lid residues [active]
1074485004273	aspartate-rich region 2; other site
1074485004274	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1074485004275	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1074485004276	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1074485004277	active site
1074485004278	ATP binding site [chemical binding]; other site
1074485004279	substrate binding site [chemical binding]; other site
1074485004280	activation loop (A-loop); other site
1074485004281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1074485004282	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485004283	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485004284	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485004285	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485004286	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074485004287	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1074485004288	Predicted membrane protein [Function unknown]; Region: COG4763
1074485004289	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1074485004290	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1074485004291	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1074485004292	putative acyl-acceptor binding pocket; other site
1074485004293	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1074485004294	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1074485004295	nucleotide binding site [chemical binding]; other site
1074485004296	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1074485004297	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074485004298	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1074485004299	NlpC/P60 family; Region: NLPC_P60; pfam00877
1074485004300	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1074485004301	NlpC/P60 family; Region: NLPC_P60; pfam00877
1074485004302	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1074485004303	heme bH binding site [chemical binding]; other site
1074485004304	intrachain domain interface; other site
1074485004305	heme bL binding site [chemical binding]; other site
1074485004306	interchain domain interface [polypeptide binding]; other site
1074485004307	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1074485004308	Qo binding site; other site
1074485004309	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1074485004310	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1074485004311	iron-sulfur cluster [ion binding]; other site
1074485004312	[2Fe-2S] cluster binding site [ion binding]; other site
1074485004313	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1074485004314	Cytochrome c; Region: Cytochrom_C; pfam00034
1074485004315	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1074485004316	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1074485004317	Subunit I/III interface [polypeptide binding]; other site
1074485004318	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1074485004319	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1074485004320	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1074485004321	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1074485004322	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1074485004323	active site
1074485004324	dimer interface [polypeptide binding]; other site
1074485004325	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1074485004326	Ligand Binding Site [chemical binding]; other site
1074485004327	Molecular Tunnel; other site
1074485004328	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1074485004329	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1074485004330	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1074485004331	homotrimer interface [polypeptide binding]; other site
1074485004332	Walker A motif; other site
1074485004333	GTP binding site [chemical binding]; other site
1074485004334	Walker B motif; other site
1074485004335	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1074485004336	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1074485004337	putative dimer interface [polypeptide binding]; other site
1074485004338	active site pocket [active]
1074485004339	putative cataytic base [active]
1074485004340	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1074485004341	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1074485004342	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1074485004343	homodimer interface [polypeptide binding]; other site
1074485004344	substrate-cofactor binding pocket; other site
1074485004345	catalytic residue [active]
1074485004346	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1074485004347	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1074485004348	interface (dimer of trimers) [polypeptide binding]; other site
1074485004349	Substrate-binding/catalytic site; other site
1074485004350	Zn-binding sites [ion binding]; other site
1074485004351	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1074485004352	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074485004353	E3 interaction surface; other site
1074485004354	lipoyl attachment site [posttranslational modification]; other site
1074485004355	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074485004356	E3 interaction surface; other site
1074485004357	lipoyl attachment site [posttranslational modification]; other site
1074485004358	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074485004359	E3 interaction surface; other site
1074485004360	lipoyl attachment site [posttranslational modification]; other site
1074485004361	e3 binding domain; Region: E3_binding; pfam02817
1074485004362	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074485004363	glycine dehydrogenase; Provisional; Region: PRK05367
1074485004364	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1074485004365	tetramer interface [polypeptide binding]; other site
1074485004366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004367	catalytic residue [active]
1074485004368	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1074485004369	tetramer interface [polypeptide binding]; other site
1074485004370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004371	catalytic residue [active]
1074485004372	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1074485004373	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1074485004374	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1074485004375	lipoyl attachment site [posttranslational modification]; other site
1074485004376	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1074485004377	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074485004378	active site
1074485004379	lipoate-protein ligase B; Provisional; Region: PRK14345
1074485004380	lipoyl synthase; Provisional; Region: PRK05481
1074485004381	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485004382	FeS/SAM binding site; other site
1074485004383	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1074485004384	RDD family; Region: RDD; pfam06271
1074485004385	glutamine synthetase, type I; Region: GlnA; TIGR00653
1074485004386	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1074485004387	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1074485004388	Htaa; Region: HtaA; pfam04213
1074485004389	Htaa; Region: HtaA; pfam04213
1074485004390	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1074485004391	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1074485004392	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1074485004393	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
1074485004394	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1074485004395	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1074485004396	active site
1074485004397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1074485004398	Predicted permease [General function prediction only]; Region: COG2056
1074485004399	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1074485004400	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
1074485004401	nudix motif; other site
1074485004402	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1074485004403	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1074485004404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004405	catalytic residue [active]
1074485004406	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1074485004407	active site
1074485004408	catalytic site [active]
1074485004409	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1074485004410	heme binding pocket [chemical binding]; other site
1074485004411	heme ligand [chemical binding]; other site
1074485004412	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1074485004413	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1074485004414	metal binding triad; other site
1074485004415	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1074485004416	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1074485004417	metal binding triad; other site
1074485004418	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1074485004419	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1074485004420	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1074485004421	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1074485004422	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1074485004423	putative active site; other site
1074485004424	putative metal binding residues [ion binding]; other site
1074485004425	signature motif; other site
1074485004426	putative triphosphate binding site [ion binding]; other site
1074485004427	CHAD domain; Region: CHAD; pfam05235
1074485004428	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1074485004429	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1074485004430	RNB domain; Region: RNB; pfam00773
1074485004431	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1074485004432	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1074485004433	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1074485004434	RNA/DNA hybrid binding site [nucleotide binding]; other site
1074485004435	active site
1074485004436	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485004437	catalytic core [active]
1074485004438	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1074485004439	Putative zinc ribbon domain; Region: DUF164; pfam02591
1074485004440	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1074485004441	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1074485004442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1074485004443	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1074485004444	hypothetical protein; Provisional; Region: PRK07908
1074485004445	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485004446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004447	homodimer interface [polypeptide binding]; other site
1074485004448	catalytic residue [active]
1074485004449	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1074485004450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485004451	motif II; other site
1074485004452	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1074485004453	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1074485004454	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1074485004455	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1074485004456	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1074485004457	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1074485004458	dimer interface [polypeptide binding]; other site
1074485004459	TPP-binding site [chemical binding]; other site
1074485004460	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1074485004461	Serine hydrolase; Region: Ser_hydrolase; cl17834
1074485004462	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1074485004463	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1074485004464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485004465	active site
1074485004466	motif I; other site
1074485004467	motif II; other site
1074485004468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485004469	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1074485004470	Beta-lactamase; Region: Beta-lactamase; pfam00144
1074485004471	Predicted membrane protein [Function unknown]; Region: COG2860
1074485004472	UPF0126 domain; Region: UPF0126; pfam03458
1074485004473	UPF0126 domain; Region: UPF0126; pfam03458
1074485004474	DNA primase; Validated; Region: dnaG; PRK05667
1074485004475	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1074485004476	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1074485004477	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1074485004478	active site
1074485004479	metal binding site [ion binding]; metal-binding site
1074485004480	interdomain interaction site; other site
1074485004481	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1074485004482	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1074485004483	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1074485004484	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1074485004485	glutaminase active site [active]
1074485004486	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1074485004487	dimer interface [polypeptide binding]; other site
1074485004488	active site
1074485004489	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1074485004490	dimer interface [polypeptide binding]; other site
1074485004491	active site
1074485004492	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1074485004493	active site
1074485004494	barstar interaction site; other site
1074485004495	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1074485004496	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074485004497	Zn2+ binding site [ion binding]; other site
1074485004498	Mg2+ binding site [ion binding]; other site
1074485004499	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1074485004500	Repair protein; Region: Repair_PSII; pfam04536
1074485004501	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1074485004502	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074485004503	motif 1; other site
1074485004504	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1074485004505	active site
1074485004506	motif 2; other site
1074485004507	motif 3; other site
1074485004508	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1074485004509	anticodon binding site; other site
1074485004510	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1074485004511	putative DNA binding site [nucleotide binding]; other site
1074485004512	putative Zn2+ binding site [ion binding]; other site
1074485004513	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1074485004514	metal binding site 2 [ion binding]; metal-binding site
1074485004515	putative DNA binding helix; other site
1074485004516	metal binding site 1 [ion binding]; metal-binding site
1074485004517	dimer interface [polypeptide binding]; other site
1074485004518	structural Zn2+ binding site [ion binding]; other site
1074485004519	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1074485004520	diiron binding motif [ion binding]; other site
1074485004521	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
1074485004522	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1074485004523	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1074485004524	catalytic residue [active]
1074485004525	putative FPP diphosphate  binding site; other site
1074485004526	putative FPP binding hydrophobic cleft; other site
1074485004527	dimer interface [polypeptide binding]; other site
1074485004528	putative IPP diphosphate binding site; other site
1074485004529	Recombination protein O N terminal; Region: RecO_N; pfam11967
1074485004530	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1074485004531	Recombination protein O C terminal; Region: RecO_C; pfam02565
1074485004532	GTPase Era; Reviewed; Region: era; PRK00089
1074485004533	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1074485004534	G1 box; other site
1074485004535	GTP/Mg2+ binding site [chemical binding]; other site
1074485004536	Switch I region; other site
1074485004537	G2 box; other site
1074485004538	Switch II region; other site
1074485004539	G3 box; other site
1074485004540	G4 box; other site
1074485004541	G5 box; other site
1074485004542	KH domain; Region: KH_2; pfam07650
1074485004543	pyridoxamine kinase; Validated; Region: PRK05756
1074485004544	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1074485004545	dimer interface [polypeptide binding]; other site
1074485004546	pyridoxal binding site [chemical binding]; other site
1074485004547	ATP binding site [chemical binding]; other site
1074485004548	Domain of unknown function DUF21; Region: DUF21; pfam01595
1074485004549	FOG: CBS domain [General function prediction only]; Region: COG0517
1074485004550	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074485004551	Transporter associated domain; Region: CorC_HlyC; cl08393
1074485004552	metal-binding heat shock protein; Provisional; Region: PRK00016
1074485004553	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1074485004554	PhoH-like protein; Region: PhoH; pfam02562
1074485004555	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1074485004556	RNA methyltransferase, RsmE family; Region: TIGR00046
1074485004557	chaperone protein DnaJ; Provisional; Region: PRK14278
1074485004558	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1074485004559	HSP70 interaction site [polypeptide binding]; other site
1074485004560	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1074485004561	Zn binding sites [ion binding]; other site
1074485004562	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1074485004563	dimer interface [polypeptide binding]; other site
1074485004564	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1074485004565	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1074485004566	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1074485004567	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074485004568	FeS/SAM binding site; other site
1074485004569	HemN C-terminal domain; Region: HemN_C; pfam06969
1074485004570	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1074485004571	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1074485004572	acyl-activating enzyme (AAE) consensus motif; other site
1074485004573	putative AMP binding site [chemical binding]; other site
1074485004574	putative active site [active]
1074485004575	putative CoA binding site [chemical binding]; other site
1074485004576	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1074485004577	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1074485004578	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1074485004579	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1074485004580	active site
1074485004581	Zn binding site [ion binding]; other site
1074485004582	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1074485004583	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1074485004584	substrate binding pocket [chemical binding]; other site
1074485004585	catalytic triad [active]
1074485004586	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1074485004587	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1074485004588	active site
1074485004589	metal binding site [ion binding]; metal-binding site
1074485004590	nudix motif; other site
1074485004591	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074485004592	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074485004593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485004594	Walker A/P-loop; other site
1074485004595	ATP binding site [chemical binding]; other site
1074485004596	Q-loop/lid; other site
1074485004597	ABC transporter signature motif; other site
1074485004598	Walker B; other site
1074485004599	D-loop; other site
1074485004600	H-loop/switch region; other site
1074485004601	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1074485004602	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1074485004603	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1074485004604	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1074485004605	active site
1074485004606	BCCT family transporter; Region: BCCT; pfam02028
1074485004607	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1074485004608	Predicted permeases [General function prediction only]; Region: COG0679
1074485004609	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074485004610	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
1074485004611	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485004612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485004613	dimer interface [polypeptide binding]; other site
1074485004614	conserved gate region; other site
1074485004615	putative PBP binding loops; other site
1074485004616	ABC-ATPase subunit interface; other site
1074485004617	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1074485004618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485004619	dimer interface [polypeptide binding]; other site
1074485004620	conserved gate region; other site
1074485004621	putative PBP binding loops; other site
1074485004622	ABC-ATPase subunit interface; other site
1074485004623	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1074485004624	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485004625	Walker A/P-loop; other site
1074485004626	ATP binding site [chemical binding]; other site
1074485004627	Q-loop/lid; other site
1074485004628	ABC transporter signature motif; other site
1074485004629	Walker B; other site
1074485004630	D-loop; other site
1074485004631	H-loop/switch region; other site
1074485004632	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485004633	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485004634	Walker A/P-loop; other site
1074485004635	ATP binding site [chemical binding]; other site
1074485004636	Q-loop/lid; other site
1074485004637	ABC transporter signature motif; other site
1074485004638	Walker B; other site
1074485004639	D-loop; other site
1074485004640	H-loop/switch region; other site
1074485004641	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485004642	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1074485004643	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1074485004644	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074485004645	catalytic residue [active]
1074485004646	Sulphur transport; Region: Sulf_transp; pfam04143
1074485004647	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1074485004648	CPxP  motif; other site
1074485004649	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485004650	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1074485004651	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074485004652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074485004653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485004654	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074485004655	putative substrate translocation pore; other site
1074485004656	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074485004657	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1074485004658	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485004659	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
1074485004660	Walker A/P-loop; other site
1074485004661	ATP binding site [chemical binding]; other site
1074485004662	Q-loop/lid; other site
1074485004663	ABC transporter signature motif; other site
1074485004664	Walker B; other site
1074485004665	D-loop; other site
1074485004666	H-loop/switch region; other site
1074485004667	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074485004668	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485004669	Walker A/P-loop; other site
1074485004670	ATP binding site [chemical binding]; other site
1074485004671	Q-loop/lid; other site
1074485004672	ABC transporter signature motif; other site
1074485004673	Walker B; other site
1074485004674	D-loop; other site
1074485004675	H-loop/switch region; other site
1074485004676	GTP-binding protein LepA; Provisional; Region: PRK05433
1074485004677	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1074485004678	G1 box; other site
1074485004679	putative GEF interaction site [polypeptide binding]; other site
1074485004680	GTP/Mg2+ binding site [chemical binding]; other site
1074485004681	Switch I region; other site
1074485004682	G2 box; other site
1074485004683	G3 box; other site
1074485004684	Switch II region; other site
1074485004685	G4 box; other site
1074485004686	G5 box; other site
1074485004687	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1074485004688	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1074485004689	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1074485004690	PemK-like protein; Region: PemK; pfam02452
1074485004691	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1074485004692	LysE type translocator; Region: LysE; cl00565
1074485004693	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1074485004694	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1074485004695	hypothetical protein; Validated; Region: PRK05629
1074485004696	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1074485004697	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1074485004698	Competence protein; Region: Competence; pfam03772
1074485004699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1074485004700	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1074485004701	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485004702	catalytic core [active]
1074485004703	Oligomerisation domain; Region: Oligomerisation; pfam02410
1074485004704	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1074485004705	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1074485004706	active site
1074485004707	(T/H)XGH motif; other site
1074485004708	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1074485004709	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1074485004710	putative catalytic cysteine [active]
1074485004711	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
1074485004712	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1074485004713	putative ligand binding site [chemical binding]; other site
1074485004714	putative NAD binding site [chemical binding]; other site
1074485004715	catalytic site [active]
1074485004716	Protein of unknown function (DUF454); Region: DUF454; cl01063
1074485004717	Predicted permease [General function prediction only]; Region: COG2985
1074485004718	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1074485004719	TrkA-C domain; Region: TrkA_C; pfam02080
1074485004720	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1074485004721	gamma-glutamyl kinase; Provisional; Region: PRK05429
1074485004722	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1074485004723	nucleotide binding site [chemical binding]; other site
1074485004724	homotetrameric interface [polypeptide binding]; other site
1074485004725	putative phosphate binding site [ion binding]; other site
1074485004726	putative allosteric binding site; other site
1074485004727	PUA domain; Region: PUA; pfam01472
1074485004728	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1074485004729	GTP1/OBG; Region: GTP1_OBG; pfam01018
1074485004730	Obg GTPase; Region: Obg; cd01898
1074485004731	G1 box; other site
1074485004732	GTP/Mg2+ binding site [chemical binding]; other site
1074485004733	Switch I region; other site
1074485004734	G2 box; other site
1074485004735	G3 box; other site
1074485004736	Switch II region; other site
1074485004737	G4 box; other site
1074485004738	G5 box; other site
1074485004739	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1074485004740	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1074485004741	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1074485004742	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1074485004743	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074485004744	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1074485004745	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1074485004746	homodimer interface [polypeptide binding]; other site
1074485004747	oligonucleotide binding site [chemical binding]; other site
1074485004748	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1074485004749	active site
1074485004750	multimer interface [polypeptide binding]; other site
1074485004751	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1074485004752	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1074485004753	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1074485004754	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1074485004755	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485004756	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074485004757	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074485004758	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1074485004759	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485004760	active site
1074485004761	HIGH motif; other site
1074485004762	nucleotide binding site [chemical binding]; other site
1074485004763	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1074485004764	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1074485004765	active site
1074485004766	KMSKS motif; other site
1074485004767	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1074485004768	tRNA binding surface [nucleotide binding]; other site
1074485004769	anticodon binding site; other site
1074485004770	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1074485004771	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1074485004772	malate dehydrogenase; Provisional; Region: PRK05442
1074485004773	NAD(P) binding site [chemical binding]; other site
1074485004774	dimer interface [polypeptide binding]; other site
1074485004775	malate binding site [chemical binding]; other site
1074485004776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485004777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485004778	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1074485004779	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
1074485004780	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1074485004781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485004782	Walker A motif; other site
1074485004783	ATP binding site [chemical binding]; other site
1074485004784	Walker B motif; other site
1074485004785	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074485004786	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1074485004787	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1074485004788	glutamine binding [chemical binding]; other site
1074485004789	catalytic triad [active]
1074485004790	hypothetical protein; Validated; Region: PRK09070
1074485004791	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1074485004792	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1074485004793	substrate-cofactor binding pocket; other site
1074485004794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485004795	catalytic residue [active]
1074485004796	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1074485004797	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1074485004798	oligomer interface [polypeptide binding]; other site
1074485004799	active site residues [active]
1074485004800	Clp protease; Region: CLP_protease; pfam00574
1074485004801	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1074485004802	oligomer interface [polypeptide binding]; other site
1074485004803	active site residues [active]
1074485004804	trigger factor; Provisional; Region: tig; PRK01490
1074485004805	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1074485004806	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1074485004807	Pirin-related protein [General function prediction only]; Region: COG1741
1074485004808	Pirin; Region: Pirin; pfam02678
1074485004809	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1074485004810	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1074485004811	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1074485004812	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1074485004813	catalytic residues [active]
1074485004814	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1074485004815	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1074485004816	Zn binding site [ion binding]; other site
1074485004817	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1074485004818	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1074485004819	apolar tunnel; other site
1074485004820	heme binding site [chemical binding]; other site
1074485004821	dimerization interface [polypeptide binding]; other site
1074485004822	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1074485004823	active site
1074485004824	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1074485004825	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1074485004826	dimer interface [polypeptide binding]; other site
1074485004827	ssDNA binding site [nucleotide binding]; other site
1074485004828	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074485004829	YcaO-like family; Region: YcaO; pfam02624
1074485004830	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1074485004831	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1074485004832	NADPH bind site [chemical binding]; other site
1074485004833	Nitroreductase family; Region: Nitroreductase; pfam00881
1074485004834	dimer interface [polypeptide binding]; other site
1074485004835	SpaB C-terminal domain; Region: SpaB_C; pfam14028
1074485004836	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1074485004837	YcaO-like family; Region: YcaO; pfam02624
1074485004838	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1074485004839	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074485004840	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074485004841	Walker A/P-loop; other site
1074485004842	ATP binding site [chemical binding]; other site
1074485004843	Q-loop/lid; other site
1074485004844	ABC transporter signature motif; other site
1074485004845	Walker B; other site
1074485004846	D-loop; other site
1074485004847	H-loop/switch region; other site
1074485004848	Copper resistance protein D; Region: CopD; pfam05425
1074485004849	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1074485004850	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1074485004851	Carbon starvation protein CstA; Region: CstA; pfam02554
1074485004852	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1074485004853	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1074485004854	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
1074485004855	active site
1074485004856	catalytic triad [active]
1074485004857	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1074485004858	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1074485004859	NADP binding site [chemical binding]; other site
1074485004860	dimer interface [polypeptide binding]; other site
1074485004861	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1074485004862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485004863	NAD(P) binding site [chemical binding]; other site
1074485004864	active site
1074485004865	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1074485004866	putative active site [active]
1074485004867	putative substrate binding site [chemical binding]; other site
1074485004868	dimer interface [polypeptide binding]; other site
1074485004869	catalytic site [active]
1074485004870	N-acetylneuraminate lyase; Region: nanA; TIGR00683
1074485004871	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1074485004872	inhibitor site; inhibition site
1074485004873	active site
1074485004874	dimer interface [polypeptide binding]; other site
1074485004875	catalytic residue [active]
1074485004876	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
1074485004877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1074485004878	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1074485004879	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1074485004880	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1074485004881	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1074485004882	catalytic residues [active]
1074485004883	catalytic nucleophile [active]
1074485004884	Presynaptic Site I dimer interface [polypeptide binding]; other site
1074485004885	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1074485004886	Synaptic Flat tetramer interface [polypeptide binding]; other site
1074485004887	Synaptic Site I dimer interface [polypeptide binding]; other site
1074485004888	DNA binding site [nucleotide binding]
1074485004889	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1074485004890	DNA-binding interface [nucleotide binding]; DNA binding site
1074485004891	aldehyde dehydrogenase; Provisional; Region: PRK11903
1074485004892	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1074485004893	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1074485004894	NAD(P) binding site [chemical binding]; other site
1074485004895	substrate binding site [chemical binding]; other site
1074485004896	dimer interface [polypeptide binding]; other site
1074485004897	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1074485004898	Isochorismatase family; Region: Isochorismatase; pfam00857
1074485004899	catalytic triad [active]
1074485004900	metal binding site [ion binding]; metal-binding site
1074485004901	conserved cis-peptide bond; other site
1074485004902	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1074485004903	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1074485004904	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1074485004905	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1074485004906	catalytic triad [active]
1074485004907	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485004908	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485004909	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1074485004910	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1074485004911	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1074485004912	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1074485004913	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1074485004914	phosphate binding site [ion binding]; other site
1074485004915	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1074485004916	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1074485004917	active site 2 [active]
1074485004918	active site 1 [active]
1074485004919	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1074485004920	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1074485004921	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1074485004922	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1074485004923	putative NAD(P) binding site [chemical binding]; other site
1074485004924	active site
1074485004925	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1074485004926	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1074485004927	active site
1074485004928	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074485004929	Histidine kinase; Region: HisKA_3; pfam07730
1074485004930	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074485004931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074485004932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485004933	active site
1074485004934	phosphorylation site [posttranslational modification]
1074485004935	intermolecular recognition site; other site
1074485004936	dimerization interface [polypeptide binding]; other site
1074485004937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074485004938	DNA binding residues [nucleotide binding]
1074485004939	dimerization interface [polypeptide binding]; other site
1074485004940	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1074485004941	CAAX protease self-immunity; Region: Abi; pfam02517
1074485004942	Glucitol operon activator protein (GutM); Region: GutM; cl01890
1074485004943	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1074485004944	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1074485004945	active site
1074485004946	dimerization interface [polypeptide binding]; other site
1074485004947	ribonuclease PH; Reviewed; Region: rph; PRK00173
1074485004948	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1074485004949	hexamer interface [polypeptide binding]; other site
1074485004950	active site
1074485004951	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1074485004952	glutamate racemase; Provisional; Region: PRK00865
1074485004953	Rhomboid family; Region: Rhomboid; pfam01694
1074485004954	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1074485004955	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1074485004956	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1074485004957	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1074485004958	active site
1074485004959	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1074485004960	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1074485004961	ATP binding site [chemical binding]; other site
1074485004962	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074485004963	putative Mg++ binding site [ion binding]; other site
1074485004964	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1074485004965	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074485004966	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1074485004967	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1074485004968	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1074485004969	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1074485004970	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485004971	motif II; other site
1074485004972	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1074485004973	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
1074485004974	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1074485004975	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1074485004976	D-pathway; other site
1074485004977	Putative ubiquinol binding site [chemical binding]; other site
1074485004978	Low-spin heme (heme b) binding site [chemical binding]; other site
1074485004979	Putative water exit pathway; other site
1074485004980	Binuclear center (heme o3/CuB) [ion binding]; other site
1074485004981	K-pathway; other site
1074485004982	Putative proton exit pathway; other site
1074485004983	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1074485004984	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1074485004985	dimer interface [polypeptide binding]; other site
1074485004986	putative radical transfer pathway; other site
1074485004987	diiron center [ion binding]; other site
1074485004988	tyrosyl radical; other site
1074485004989	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1074485004990	Ferritin-like domain; Region: Ferritin; pfam00210
1074485004991	ferroxidase diiron center [ion binding]; other site
1074485004992	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1074485004993	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1074485004994	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1074485004995	active site
1074485004996	dimer interface [polypeptide binding]; other site
1074485004997	catalytic residues [active]
1074485004998	effector binding site; other site
1074485004999	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1074485005000	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1074485005001	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1074485005002	catalytic residues [active]
1074485005003	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1074485005004	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1074485005005	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1074485005006	homodimer interface [polypeptide binding]; other site
1074485005007	NAD binding pocket [chemical binding]; other site
1074485005008	ATP binding pocket [chemical binding]; other site
1074485005009	Mg binding site [ion binding]; other site
1074485005010	active-site loop [active]
1074485005011	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1074485005012	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1074485005013	dimerization interface [polypeptide binding]; other site
1074485005014	putative DNA binding site [nucleotide binding]; other site
1074485005015	putative Zn2+ binding site [ion binding]; other site
1074485005016	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1074485005017	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074485005018	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1074485005019	Thioredoxin; Region: Thioredoxin_4; cl17273
1074485005020	Predicted membrane protein [Function unknown]; Region: COG2259
1074485005021	phosphoglucomutase; Validated; Region: PRK07564
1074485005022	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1074485005023	active site
1074485005024	substrate binding site [chemical binding]; other site
1074485005025	metal binding site [ion binding]; metal-binding site
1074485005026	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
1074485005027	CrcB-like protein; Region: CRCB; pfam02537
1074485005028	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074485005029	FtsX-like permease family; Region: FtsX; pfam02687
1074485005030	FtsX-like permease family; Region: FtsX; pfam02687
1074485005031	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074485005032	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074485005033	Walker A/P-loop; other site
1074485005034	ATP binding site [chemical binding]; other site
1074485005035	Q-loop/lid; other site
1074485005036	ABC transporter signature motif; other site
1074485005037	Walker B; other site
1074485005038	D-loop; other site
1074485005039	H-loop/switch region; other site
1074485005040	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1074485005041	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1074485005042	hinge; other site
1074485005043	active site
1074485005044	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1074485005045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074485005046	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074485005047	DNA binding residues [nucleotide binding]
1074485005048	dimerization interface [polypeptide binding]; other site
1074485005049	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1074485005050	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074485005051	dimer interface [polypeptide binding]; other site
1074485005052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485005053	catalytic residue [active]
1074485005054	serine O-acetyltransferase; Region: cysE; TIGR01172
1074485005055	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1074485005056	trimer interface [polypeptide binding]; other site
1074485005057	active site
1074485005058	substrate binding site [chemical binding]; other site
1074485005059	CoA binding site [chemical binding]; other site
1074485005060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485005061	Coenzyme A binding pocket [chemical binding]; other site
1074485005062	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
1074485005063	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
1074485005064	putative active site [active]
1074485005065	metal binding site [ion binding]; metal-binding site
1074485005066	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1074485005067	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1074485005068	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1074485005069	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074485005070	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1074485005071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485005072	Walker A/P-loop; other site
1074485005073	ATP binding site [chemical binding]; other site
1074485005074	Q-loop/lid; other site
1074485005075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485005076	ABC transporter signature motif; other site
1074485005077	ABC transporter signature motif; other site
1074485005078	Walker B; other site
1074485005079	Walker B; other site
1074485005080	D-loop; other site
1074485005081	D-loop; other site
1074485005082	H-loop/switch region; other site
1074485005083	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1074485005084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074485005085	Walker A/P-loop; other site
1074485005086	ATP binding site [chemical binding]; other site
1074485005087	Q-loop/lid; other site
1074485005088	ABC transporter signature motif; other site
1074485005089	Walker B; other site
1074485005090	D-loop; other site
1074485005091	H-loop/switch region; other site
1074485005092	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1074485005093	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1074485005094	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1074485005095	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1074485005096	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1074485005097	FMN binding site [chemical binding]; other site
1074485005098	active site
1074485005099	catalytic residues [active]
1074485005100	substrate binding site [chemical binding]; other site
1074485005101	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1074485005102	PhoU domain; Region: PhoU; pfam01895
1074485005103	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1074485005104	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1074485005105	Walker A/P-loop; other site
1074485005106	ATP binding site [chemical binding]; other site
1074485005107	Q-loop/lid; other site
1074485005108	ABC transporter signature motif; other site
1074485005109	Walker B; other site
1074485005110	D-loop; other site
1074485005111	H-loop/switch region; other site
1074485005112	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1074485005113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485005114	dimer interface [polypeptide binding]; other site
1074485005115	conserved gate region; other site
1074485005116	putative PBP binding loops; other site
1074485005117	ABC-ATPase subunit interface; other site
1074485005118	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1074485005119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485005120	dimer interface [polypeptide binding]; other site
1074485005121	conserved gate region; other site
1074485005122	putative PBP binding loops; other site
1074485005123	ABC-ATPase subunit interface; other site
1074485005124	PBP superfamily domain; Region: PBP_like_2; cl17296
1074485005125	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1074485005126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485005127	Coenzyme A binding pocket [chemical binding]; other site
1074485005128	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1074485005129	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1074485005130	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1074485005131	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1074485005132	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1074485005133	heme-binding site [chemical binding]; other site
1074485005134	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1074485005135	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1074485005136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485005137	catalytic residue [active]
1074485005138	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1074485005139	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1074485005140	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1074485005141	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1074485005142	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1074485005143	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1074485005144	dimerization interface [polypeptide binding]; other site
1074485005145	putative ATP binding site [chemical binding]; other site
1074485005146	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1074485005147	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1074485005148	active site
1074485005149	tetramer interface [polypeptide binding]; other site
1074485005150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485005151	active site
1074485005152	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1074485005153	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1074485005154	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1074485005155	dimer interface [polypeptide binding]; other site
1074485005156	putative radical transfer pathway; other site
1074485005157	diiron center [ion binding]; other site
1074485005158	tyrosyl radical; other site
1074485005159	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1074485005160	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1074485005161	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1074485005162	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1074485005163	dimerization interface [polypeptide binding]; other site
1074485005164	ATP binding site [chemical binding]; other site
1074485005165	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1074485005166	dimerization interface [polypeptide binding]; other site
1074485005167	ATP binding site [chemical binding]; other site
1074485005168	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1074485005169	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1074485005170	putative active site [active]
1074485005171	catalytic triad [active]
1074485005172	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1074485005173	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1074485005174	catalytic residues [active]
1074485005175	dimer interface [polypeptide binding]; other site
1074485005176	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1074485005177	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1074485005178	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1074485005179	ATP binding site [chemical binding]; other site
1074485005180	active site
1074485005181	substrate binding site [chemical binding]; other site
1074485005182	adenylosuccinate lyase; Region: purB; TIGR00928
1074485005183	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1074485005184	tetramer interface [polypeptide binding]; other site
1074485005185	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1074485005186	TrkA-N domain; Region: TrkA_N; pfam02254
1074485005187	TrkA-C domain; Region: TrkA_C; pfam02080
1074485005188	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1074485005189	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1074485005190	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1074485005191	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1074485005192	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1074485005193	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1074485005194	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1074485005195	nucleotide binding site/active site [active]
1074485005196	HIT family signature motif; other site
1074485005197	catalytic residue [active]
1074485005198	PGAP1-like protein; Region: PGAP1; pfam07819
1074485005199	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1074485005200	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074485005201	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074485005202	dimerization interface [polypeptide binding]; other site
1074485005203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074485005204	dimer interface [polypeptide binding]; other site
1074485005205	phosphorylation site [posttranslational modification]
1074485005206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485005207	ATP binding site [chemical binding]; other site
1074485005208	Mg2+ binding site [ion binding]; other site
1074485005209	G-X-G motif; other site
1074485005210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074485005211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485005212	active site
1074485005213	phosphorylation site [posttranslational modification]
1074485005214	intermolecular recognition site; other site
1074485005215	dimerization interface [polypeptide binding]; other site
1074485005216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074485005217	DNA binding site [nucleotide binding]
1074485005218	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1074485005219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005220	putative substrate translocation pore; other site
1074485005221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485005222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485005223	Predicted esterase [General function prediction only]; Region: COG0627
1074485005224	S-formylglutathione hydrolase; Region: PLN02442
1074485005225	xanthine permease; Region: pbuX; TIGR03173
1074485005226	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
1074485005227	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1074485005228	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1074485005229	putative active site [active]
1074485005230	pyruvate dehydrogenase; Provisional; Region: PRK06546
1074485005231	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1074485005232	PYR/PP interface [polypeptide binding]; other site
1074485005233	tetramer interface [polypeptide binding]; other site
1074485005234	dimer interface [polypeptide binding]; other site
1074485005235	TPP binding site [chemical binding]; other site
1074485005236	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074485005237	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1074485005238	TPP-binding site [chemical binding]; other site
1074485005239	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1074485005240	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1074485005241	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1074485005242	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1074485005243	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1074485005244	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1074485005245	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1074485005246	active site
1074485005247	homotetramer interface [polypeptide binding]; other site
1074485005248	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1074485005249	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1074485005250	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074485005251	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074485005252	DNA binding site [nucleotide binding]
1074485005253	domain linker motif; other site
1074485005254	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
1074485005255	putative dimerization interface [polypeptide binding]; other site
1074485005256	putative ligand binding site [chemical binding]; other site
1074485005257	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1074485005258	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074485005259	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1074485005260	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074485005261	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1074485005262	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485005263	active site
1074485005264	HIGH motif; other site
1074485005265	nucleotide binding site [chemical binding]; other site
1074485005266	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1074485005267	KMSKS motif; other site
1074485005268	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1074485005269	tRNA binding surface [nucleotide binding]; other site
1074485005270	anticodon binding site; other site
1074485005271	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1074485005272	homotrimer interaction site [polypeptide binding]; other site
1074485005273	zinc binding site [ion binding]; other site
1074485005274	CDP-binding sites; other site
1074485005275	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1074485005276	substrate binding site; other site
1074485005277	dimer interface; other site
1074485005278	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1074485005279	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1074485005280	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1074485005281	Walker A motif; other site
1074485005282	ATP binding site [chemical binding]; other site
1074485005283	Walker B motif; other site
1074485005284	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1074485005285	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1074485005286	active site clefts [active]
1074485005287	zinc binding site [ion binding]; other site
1074485005288	dimer interface [polypeptide binding]; other site
1074485005289	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074485005290	endonuclease III; Region: ENDO3c; smart00478
1074485005291	minor groove reading motif; other site
1074485005292	helix-hairpin-helix signature motif; other site
1074485005293	substrate binding pocket [chemical binding]; other site
1074485005294	active site
1074485005295	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
1074485005296	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1074485005297	Clp amino terminal domain; Region: Clp_N; pfam02861
1074485005298	Clp amino terminal domain; Region: Clp_N; pfam02861
1074485005299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485005300	Walker A motif; other site
1074485005301	ATP binding site [chemical binding]; other site
1074485005302	Walker B motif; other site
1074485005303	arginine finger; other site
1074485005304	UvrB/uvrC motif; Region: UVR; pfam02151
1074485005305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485005306	Walker A motif; other site
1074485005307	ATP binding site [chemical binding]; other site
1074485005308	Walker B motif; other site
1074485005309	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1074485005310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005311	putative substrate translocation pore; other site
1074485005312	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1074485005313	active site
1074485005314	tetramer interface [polypeptide binding]; other site
1074485005315	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1074485005316	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074485005317	CAAX protease self-immunity; Region: Abi; pfam02517
1074485005318	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1074485005319	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1074485005320	dimer interface [polypeptide binding]; other site
1074485005321	putative anticodon binding site; other site
1074485005322	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074485005323	motif 1; other site
1074485005324	dimer interface [polypeptide binding]; other site
1074485005325	active site
1074485005326	motif 2; other site
1074485005327	motif 3; other site
1074485005328	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1074485005329	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1074485005330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1074485005331	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074485005332	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1074485005333	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1074485005334	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1074485005335	NAD(P) binding site [chemical binding]; other site
1074485005336	catalytic residues [active]
1074485005337	BCCT family transporter; Region: BCCT; cl00569
1074485005338	choline dehydrogenase; Validated; Region: PRK02106
1074485005339	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1074485005340	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1074485005341	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485005342	active site
1074485005343	nucleotide binding site [chemical binding]; other site
1074485005344	HIGH motif; other site
1074485005345	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485005346	KMSKS motif; other site
1074485005347	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1074485005348	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1074485005349	catalytic center binding site [active]
1074485005350	ATP binding site [chemical binding]; other site
1074485005351	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1074485005352	homooctamer interface [polypeptide binding]; other site
1074485005353	active site
1074485005354	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1074485005355	dihydropteroate synthase; Region: DHPS; TIGR01496
1074485005356	substrate binding pocket [chemical binding]; other site
1074485005357	dimer interface [polypeptide binding]; other site
1074485005358	inhibitor binding site; inhibition site
1074485005359	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1074485005360	GTP cyclohydrolase I; Provisional; Region: PLN03044
1074485005361	homodecamer interface [polypeptide binding]; other site
1074485005362	active site
1074485005363	putative catalytic site residues [active]
1074485005364	zinc binding site [ion binding]; other site
1074485005365	GTP-CH-I/GFRP interaction surface; other site
1074485005366	FtsH Extracellular; Region: FtsH_ext; pfam06480
1074485005367	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1074485005368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485005369	Walker A motif; other site
1074485005370	ATP binding site [chemical binding]; other site
1074485005371	Walker B motif; other site
1074485005372	arginine finger; other site
1074485005373	Peptidase family M41; Region: Peptidase_M41; pfam01434
1074485005374	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485005375	active site
1074485005376	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1074485005377	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1074485005378	Ligand Binding Site [chemical binding]; other site
1074485005379	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1074485005380	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1074485005381	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1074485005382	dimer interface [polypeptide binding]; other site
1074485005383	substrate binding site [chemical binding]; other site
1074485005384	metal binding sites [ion binding]; metal-binding site
1074485005385	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074485005386	active site residue [active]
1074485005387	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1074485005388	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074485005389	Secretory lipase; Region: LIP; pfam03583
1074485005390	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1074485005391	MarR family; Region: MarR_2; pfam12802
1074485005392	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074485005393	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1074485005394	acyl-activating enzyme (AAE) consensus motif; other site
1074485005395	AMP binding site [chemical binding]; other site
1074485005396	active site
1074485005397	CoA binding site [chemical binding]; other site
1074485005398	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1074485005399	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1074485005400	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074485005401	putative trimer interface [polypeptide binding]; other site
1074485005402	putative CoA binding site [chemical binding]; other site
1074485005403	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074485005404	putative trimer interface [polypeptide binding]; other site
1074485005405	putative CoA binding site [chemical binding]; other site
1074485005406	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1074485005407	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1074485005408	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1074485005409	ring oligomerisation interface [polypeptide binding]; other site
1074485005410	ATP/Mg binding site [chemical binding]; other site
1074485005411	stacking interactions; other site
1074485005412	hinge regions; other site
1074485005413	hypothetical protein; Provisional; Region: PRK07907
1074485005414	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1074485005415	active site
1074485005416	metal binding site [ion binding]; metal-binding site
1074485005417	dimer interface [polypeptide binding]; other site
1074485005418	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1074485005419	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074485005420	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1074485005421	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1074485005422	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1074485005423	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1074485005424	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1074485005425	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074485005426	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1074485005427	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
1074485005428	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
1074485005429	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1074485005430	carboxylate-amine ligase; Provisional; Region: PRK13517
1074485005431	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1074485005432	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1074485005433	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1074485005434	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1074485005435	active site
1074485005436	catalytic residues [active]
1074485005437	metal binding site [ion binding]; metal-binding site
1074485005438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074485005439	Coenzyme A binding pocket [chemical binding]; other site
1074485005440	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1074485005441	putative catalytic site [active]
1074485005442	putative phosphate binding site [ion binding]; other site
1074485005443	active site
1074485005444	metal binding site A [ion binding]; metal-binding site
1074485005445	DNA binding site [nucleotide binding]
1074485005446	putative AP binding site [nucleotide binding]; other site
1074485005447	putative metal binding site B [ion binding]; other site
1074485005448	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1074485005449	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1074485005450	putative active site [active]
1074485005451	catalytic site [active]
1074485005452	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1074485005453	putative active site [active]
1074485005454	catalytic site [active]
1074485005455	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1074485005456	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074485005457	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1074485005458	Walker A/P-loop; other site
1074485005459	ATP binding site [chemical binding]; other site
1074485005460	Q-loop/lid; other site
1074485005461	ABC transporter signature motif; other site
1074485005462	Walker B; other site
1074485005463	D-loop; other site
1074485005464	H-loop/switch region; other site
1074485005465	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1074485005466	nudix motif; other site
1074485005467	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1074485005468	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1074485005469	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074485005470	substrate binding pocket [chemical binding]; other site
1074485005471	membrane-bound complex binding site; other site
1074485005472	hinge residues; other site
1074485005473	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1074485005474	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1074485005475	active site
1074485005476	ATP binding site [chemical binding]; other site
1074485005477	substrate binding site [chemical binding]; other site
1074485005478	activation loop (A-loop); other site
1074485005479	propionate/acetate kinase; Provisional; Region: PRK12379
1074485005480	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1074485005481	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1074485005482	ferredoxin-NADP+ reductase; Region: PLN02852
1074485005483	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074485005484	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074485005485	Coenzyme A binding pocket [chemical binding]; other site
1074485005486	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1074485005487	active site
1074485005488	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1074485005489	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074485005490	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
1074485005491	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485005492	active site
1074485005493	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1074485005494	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1074485005495	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1074485005496	catalytic residues [active]
1074485005497	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1074485005498	ResB-like family; Region: ResB; pfam05140
1074485005499	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1074485005500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074485005501	TPR motif; other site
1074485005502	TPR repeat; Region: TPR_11; pfam13414
1074485005503	binding surface
1074485005504	Cytochrome c552; Region: Cytochrom_C552; pfam02335
1074485005505	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1074485005506	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
1074485005507	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1074485005508	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1074485005509	GDP-binding site [chemical binding]; other site
1074485005510	ACT binding site; other site
1074485005511	IMP binding site; other site
1074485005512	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1074485005513	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074485005514	Walker A/P-loop; other site
1074485005515	ATP binding site [chemical binding]; other site
1074485005516	Q-loop/lid; other site
1074485005517	ABC transporter signature motif; other site
1074485005518	Walker B; other site
1074485005519	D-loop; other site
1074485005520	H-loop/switch region; other site
1074485005521	Predicted transcriptional regulators [Transcription]; Region: COG1695
1074485005522	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1074485005523	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1074485005524	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1074485005525	active site
1074485005526	intersubunit interface [polypeptide binding]; other site
1074485005527	zinc binding site [ion binding]; other site
1074485005528	Na+ binding site [ion binding]; other site
1074485005529	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
1074485005530	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074485005531	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074485005532	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074485005533	active site
1074485005534	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1074485005535	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1074485005536	active site residue [active]
1074485005537	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1074485005538	active site residue [active]
1074485005539	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1074485005540	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1074485005541	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1074485005542	active site
1074485005543	catalytic site [active]
1074485005544	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1074485005545	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1074485005546	Clp amino terminal domain; Region: Clp_N; pfam02861
1074485005547	Clp amino terminal domain; Region: Clp_N; pfam02861
1074485005548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485005549	Walker A motif; other site
1074485005550	ATP binding site [chemical binding]; other site
1074485005551	Walker B motif; other site
1074485005552	arginine finger; other site
1074485005553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074485005554	Walker A motif; other site
1074485005555	ATP binding site [chemical binding]; other site
1074485005556	Walker B motif; other site
1074485005557	arginine finger; other site
1074485005558	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1074485005559	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1074485005560	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074485005561	Walker A/P-loop; other site
1074485005562	ATP binding site [chemical binding]; other site
1074485005563	Q-loop/lid; other site
1074485005564	ABC transporter signature motif; other site
1074485005565	Walker B; other site
1074485005566	D-loop; other site
1074485005567	H-loop/switch region; other site
1074485005568	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1074485005569	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1074485005570	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1074485005571	FAD binding pocket [chemical binding]; other site
1074485005572	conserved FAD binding motif [chemical binding]; other site
1074485005573	phosphate binding motif [ion binding]; other site
1074485005574	beta-alpha-beta structure motif; other site
1074485005575	NAD binding pocket [chemical binding]; other site
1074485005576	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074485005577	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074485005578	FtsX-like permease family; Region: FtsX; pfam02687
1074485005579	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074485005580	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074485005581	Walker A/P-loop; other site
1074485005582	ATP binding site [chemical binding]; other site
1074485005583	Q-loop/lid; other site
1074485005584	ABC transporter signature motif; other site
1074485005585	Walker B; other site
1074485005586	D-loop; other site
1074485005587	H-loop/switch region; other site
1074485005588	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1074485005589	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1074485005590	putative active site [active]
1074485005591	catalytic triad [active]
1074485005592	putative dimer interface [polypeptide binding]; other site
1074485005593	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1074485005594	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1074485005595	NAD binding site [chemical binding]; other site
1074485005596	substrate binding site [chemical binding]; other site
1074485005597	catalytic Zn binding site [ion binding]; other site
1074485005598	tetramer interface [polypeptide binding]; other site
1074485005599	structural Zn binding site [ion binding]; other site
1074485005600	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1074485005601	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1074485005602	NAD(P) binding site [chemical binding]; other site
1074485005603	catalytic residues [active]
1074485005604	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
1074485005605	active site
1074485005606	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1074485005607	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1074485005608	DNA binding residues [nucleotide binding]
1074485005609	chaperone protein DnaJ; Provisional; Region: PRK14279
1074485005610	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1074485005611	HSP70 interaction site [polypeptide binding]; other site
1074485005612	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1074485005613	Zn binding sites [ion binding]; other site
1074485005614	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1074485005615	dimer interface [polypeptide binding]; other site
1074485005616	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1074485005617	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1074485005618	dimer interface [polypeptide binding]; other site
1074485005619	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1074485005620	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1074485005621	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1074485005622	nucleotide binding site [chemical binding]; other site
1074485005623	NEF interaction site [polypeptide binding]; other site
1074485005624	SBD interface [polypeptide binding]; other site
1074485005625	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1074485005626	active site
1074485005627	catalytic site [active]
1074485005628	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1074485005629	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1074485005630	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485005631	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
1074485005632	Walker A/P-loop; other site
1074485005633	ATP binding site [chemical binding]; other site
1074485005634	Q-loop/lid; other site
1074485005635	ABC transporter signature motif; other site
1074485005636	Walker B; other site
1074485005637	D-loop; other site
1074485005638	H-loop/switch region; other site
1074485005639	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074485005640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485005641	dimer interface [polypeptide binding]; other site
1074485005642	conserved gate region; other site
1074485005643	putative PBP binding loops; other site
1074485005644	ABC-ATPase subunit interface; other site
1074485005645	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1074485005646	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485005647	Walker A/P-loop; other site
1074485005648	ATP binding site [chemical binding]; other site
1074485005649	Q-loop/lid; other site
1074485005650	ABC transporter signature motif; other site
1074485005651	Walker B; other site
1074485005652	D-loop; other site
1074485005653	H-loop/switch region; other site
1074485005654	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485005655	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485005656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485005657	dimer interface [polypeptide binding]; other site
1074485005658	conserved gate region; other site
1074485005659	putative PBP binding loops; other site
1074485005660	ABC-ATPase subunit interface; other site
1074485005661	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074485005662	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1074485005663	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1074485005664	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1074485005665	adrenodoxin reductase; Provisional; Region: PTZ00188
1074485005666	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1074485005667	4Fe-4S binding domain; Region: Fer4; cl02805
1074485005668	4Fe-4S binding domain; Region: Fer4; pfam00037
1074485005669	Cysteine-rich domain; Region: CCG; pfam02754
1074485005670	Cysteine-rich domain; Region: CCG; pfam02754
1074485005671	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1074485005672	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1074485005673	dimerization interface [polypeptide binding]; other site
1074485005674	putative DNA binding site [nucleotide binding]; other site
1074485005675	putative Zn2+ binding site [ion binding]; other site
1074485005676	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074485005677	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485005678	Walker A/P-loop; other site
1074485005679	ATP binding site [chemical binding]; other site
1074485005680	Q-loop/lid; other site
1074485005681	ABC transporter signature motif; other site
1074485005682	Walker B; other site
1074485005683	D-loop; other site
1074485005684	H-loop/switch region; other site
1074485005685	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1074485005686	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485005687	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485005688	putative PBP binding regions; other site
1074485005689	ABC-ATPase subunit  interface; other site
1074485005690	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1074485005691	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074485005692	intersubunit interface [polypeptide binding]; other site
1074485005693	UreD urease accessory protein; Region: UreD; cl00530
1074485005694	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074485005695	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1074485005696	UreF; Region: UreF; pfam01730
1074485005697	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1074485005698	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1074485005699	dimer interface [polypeptide binding]; other site
1074485005700	catalytic residues [active]
1074485005701	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1074485005702	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1074485005703	subunit interactions [polypeptide binding]; other site
1074485005704	active site
1074485005705	flap region; other site
1074485005706	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1074485005707	gamma-beta subunit interface [polypeptide binding]; other site
1074485005708	alpha-beta subunit interface [polypeptide binding]; other site
1074485005709	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1074485005710	alpha-gamma subunit interface [polypeptide binding]; other site
1074485005711	beta-gamma subunit interface [polypeptide binding]; other site
1074485005712	aminotransferase AlaT; Validated; Region: PRK09265
1074485005713	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074485005714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485005715	homodimer interface [polypeptide binding]; other site
1074485005716	catalytic residue [active]
1074485005717	YibE/F-like protein; Region: YibE_F; pfam07907
1074485005718	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
1074485005719	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1074485005720	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1074485005721	dimer interface [polypeptide binding]; other site
1074485005722	putative anticodon binding site; other site
1074485005723	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074485005724	motif 1; other site
1074485005725	dimer interface [polypeptide binding]; other site
1074485005726	active site
1074485005727	motif 2; other site
1074485005728	motif 3; other site
1074485005729	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1074485005730	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1074485005731	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1074485005732	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1074485005733	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1074485005734	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1074485005735	trimer interface [polypeptide binding]; other site
1074485005736	active site
1074485005737	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1074485005738	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1074485005739	NAD(P) binding site [chemical binding]; other site
1074485005740	catalytic residues [active]
1074485005741	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
1074485005742	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1074485005743	VanW like protein; Region: VanW; pfam04294
1074485005744	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1074485005745	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1074485005746	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
1074485005747	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1074485005748	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1074485005749	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074485005750	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1074485005751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485005752	S-adenosylmethionine binding site [chemical binding]; other site
1074485005753	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1074485005754	active site
1074485005755	substrate-binding site [chemical binding]; other site
1074485005756	metal-binding site [ion binding]
1074485005757	GTP binding site [chemical binding]; other site
1074485005758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074485005759	S-adenosylmethionine binding site [chemical binding]; other site
1074485005760	LabA_like proteins; Region: LabA_like; cd06167
1074485005761	putative metal binding site [ion binding]; other site
1074485005762	MMPL family; Region: MMPL; pfam03176
1074485005763	MMPL family; Region: MMPL; pfam03176
1074485005764	Predicted integral membrane protein [Function unknown]; Region: COG0392
1074485005765	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1074485005766	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1074485005767	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1074485005768	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1074485005769	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1074485005770	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
1074485005771	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1074485005772	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1074485005773	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1074485005774	active site
1074485005775	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1074485005776	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1074485005777	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1074485005778	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1074485005779	acyl-activating enzyme (AAE) consensus motif; other site
1074485005780	active site
1074485005781	Cutinase; Region: Cutinase; pfam01083
1074485005782	Putative esterase; Region: Esterase; pfam00756
1074485005783	S-formylglutathione hydrolase; Region: PLN02442
1074485005784	LGFP repeat; Region: LGFP; pfam08310
1074485005785	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1074485005786	LGFP repeat; Region: LGFP; pfam08310
1074485005787	LGFP repeat; Region: LGFP; pfam08310
1074485005788	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1074485005789	Predicted esterase [General function prediction only]; Region: COG0627
1074485005790	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1074485005791	UbiA prenyltransferase family; Region: UbiA; pfam01040
1074485005792	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1074485005793	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1074485005794	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1074485005795	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1074485005796	Repair protein; Region: Repair_PSII; pfam04536
1074485005797	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1074485005798	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1074485005799	active site
1074485005800	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1074485005801	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074485005802	active site
1074485005803	catalytic site [active]
1074485005804	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1074485005805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005806	putative substrate translocation pore; other site
1074485005807	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1074485005808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074485005809	UDP-galactopyranose mutase; Region: GLF; pfam03275
1074485005810	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074485005811	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074485005812	Walker A/P-loop; other site
1074485005813	ATP binding site [chemical binding]; other site
1074485005814	Q-loop/lid; other site
1074485005815	ABC transporter signature motif; other site
1074485005816	Walker B; other site
1074485005817	D-loop; other site
1074485005818	H-loop/switch region; other site
1074485005819	FecCD transport family; Region: FecCD; pfam01032
1074485005820	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074485005821	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074485005822	putative PBP binding regions; other site
1074485005823	ABC-ATPase subunit  interface; other site
1074485005824	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074485005825	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1074485005826	putative binding site residues; other site
1074485005827	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1074485005828	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1074485005829	amidase catalytic site [active]
1074485005830	Zn binding residues [ion binding]; other site
1074485005831	substrate binding site [chemical binding]; other site
1074485005832	LGFP repeat; Region: LGFP; pfam08310
1074485005833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485005834	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1074485005835	active site
1074485005836	motif I; other site
1074485005837	motif II; other site
1074485005838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074485005839	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1074485005840	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1074485005841	putative acyl-acceptor binding pocket; other site
1074485005842	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1074485005843	seryl-tRNA synthetase; Provisional; Region: PRK05431
1074485005844	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1074485005845	dimer interface [polypeptide binding]; other site
1074485005846	active site
1074485005847	motif 1; other site
1074485005848	motif 2; other site
1074485005849	motif 3; other site
1074485005850	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074485005851	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074485005852	DNA-binding site [nucleotide binding]; DNA binding site
1074485005853	UTRA domain; Region: UTRA; pfam07702
1074485005854	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1074485005855	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074485005856	catalytic core [active]
1074485005857	prephenate dehydratase; Provisional; Region: PRK11898
1074485005858	Prephenate dehydratase; Region: PDT; pfam00800
1074485005859	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1074485005860	putative L-Phe binding site [chemical binding]; other site
1074485005861	Amidase; Region: Amidase; cl11426
1074485005862	CAAX protease self-immunity; Region: Abi; pfam02517
1074485005863	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1074485005864	Htaa; Region: HtaA; pfam04213
1074485005865	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1074485005866	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1074485005867	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1074485005868	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1074485005869	catalytic triad [active]
1074485005870	catalytic triad [active]
1074485005871	oxyanion hole [active]
1074485005872	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074485005873	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1074485005874	putative active site [active]
1074485005875	catalytic site [active]
1074485005876	putative metal binding site [ion binding]; other site
1074485005877	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1074485005878	active site
1074485005879	catalytic motif [active]
1074485005880	Zn binding site [ion binding]; other site
1074485005881	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1074485005882	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1074485005883	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1074485005884	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1074485005885	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1074485005886	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1074485005887	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074485005888	NAD binding site [chemical binding]; other site
1074485005889	dimer interface [polypeptide binding]; other site
1074485005890	substrate binding site [chemical binding]; other site
1074485005891	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1074485005892	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1074485005893	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1074485005894	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1074485005895	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074485005896	Predicted flavoprotein [General function prediction only]; Region: COG0431
1074485005897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005898	putative substrate translocation pore; other site
1074485005899	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1074485005900	Abi-like protein; Region: Abi_2; pfam07751
1074485005901	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1074485005902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005904	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1074485005905	homodimer interface [polypeptide binding]; other site
1074485005906	chemical substrate binding site [chemical binding]; other site
1074485005907	oligomer interface [polypeptide binding]; other site
1074485005908	metal binding site [ion binding]; metal-binding site
1074485005909	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1074485005910	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1074485005911	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1074485005912	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074485005913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485005914	active site
1074485005915	phosphorylation site [posttranslational modification]
1074485005916	intermolecular recognition site; other site
1074485005917	dimerization interface [polypeptide binding]; other site
1074485005918	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074485005919	DNA binding residues [nucleotide binding]
1074485005920	dimerization interface [polypeptide binding]; other site
1074485005921	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074485005922	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
1074485005923	Histidine kinase; Region: HisKA_3; pfam07730
1074485005924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074485005925	ATP binding site [chemical binding]; other site
1074485005926	Mg2+ binding site [ion binding]; other site
1074485005927	G-X-G motif; other site
1074485005928	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
1074485005929	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
1074485005930	active site
1074485005931	catalytic site [active]
1074485005932	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
1074485005933	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1074485005934	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074485005935	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074485005936	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1074485005937	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074485005938	Ligand Binding Site [chemical binding]; other site
1074485005939	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074485005940	Ligand Binding Site [chemical binding]; other site
1074485005941	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1074485005942	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074485005943	active site
1074485005944	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1074485005945	Predicted transcriptional regulators [Transcription]; Region: COG1725
1074485005946	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074485005947	DNA-binding site [nucleotide binding]; DNA binding site
1074485005948	LabA_like proteins; Region: LabA_like; cd06167
1074485005949	putative metal binding site [ion binding]; other site
1074485005950	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1074485005951	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1074485005952	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1074485005953	catalytic residues [active]
1074485005954	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074485005955	metal-binding site [ion binding]
1074485005956	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074485005957	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074485005958	metal-binding site [ion binding]
1074485005959	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074485005960	benzoate transport; Region: 2A0115; TIGR00895
1074485005961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005962	putative substrate translocation pore; other site
1074485005963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074485005964	replicative DNA helicase; Provisional; Region: PRK05636
1074485005965	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1074485005966	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1074485005967	Walker A motif; other site
1074485005968	ATP binding site [chemical binding]; other site
1074485005969	Walker B motif; other site
1074485005970	DNA binding loops [nucleotide binding]
1074485005971	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1074485005972	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1074485005973	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1074485005974	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1074485005975	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1074485005976	dimer interface [polypeptide binding]; other site
1074485005977	ssDNA binding site [nucleotide binding]; other site
1074485005978	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074485005979	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1074485005980	Predicted integral membrane protein [Function unknown]; Region: COG5650
1074485005981	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1074485005982	Transglycosylase; Region: Transgly; pfam00912
1074485005983	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1074485005984	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1074485005985	MarR family; Region: MarR; pfam01047
1074485005986	MarR family; Region: MarR_2; cl17246
1074485005987	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074485005988	Ligand Binding Site [chemical binding]; other site
1074485005989	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074485005990	Ligand Binding Site [chemical binding]; other site
1074485005991	short chain dehydrogenase; Provisional; Region: PRK08219
1074485005992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074485005993	NAD(P) binding site [chemical binding]; other site
1074485005994	active site
1074485005995	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1074485005996	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1074485005997	active site residue [active]
1074485005998	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1074485005999	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1074485006000	dimerization interface [polypeptide binding]; other site
1074485006001	DPS ferroxidase diiron center [ion binding]; other site
1074485006002	ion pore; other site
1074485006003	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1074485006004	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1074485006005	putative DNA binding site [nucleotide binding]; other site
1074485006006	catalytic residue [active]
1074485006007	putative H2TH interface [polypeptide binding]; other site
1074485006008	putative catalytic residues [active]
1074485006009	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1074485006010	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1074485006011	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
1074485006012	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1074485006013	putative substrate binding site [chemical binding]; other site
1074485006014	putative ATP binding site [chemical binding]; other site
1074485006015	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
1074485006016	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1074485006017	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1074485006018	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1074485006019	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1074485006020	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1074485006021	HIGH motif; other site
1074485006022	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1074485006023	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485006024	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074485006025	active site
1074485006026	KMSKS motif; other site
1074485006027	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1074485006028	tRNA binding surface [nucleotide binding]; other site
1074485006029	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074485006030	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074485006031	Walker A/P-loop; other site
1074485006032	ATP binding site [chemical binding]; other site
1074485006033	Q-loop/lid; other site
1074485006034	ABC transporter signature motif; other site
1074485006035	Walker B; other site
1074485006036	D-loop; other site
1074485006037	H-loop/switch region; other site
1074485006038	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074485006039	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074485006040	FtsX-like permease family; Region: FtsX; pfam02687
1074485006041	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1074485006042	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1074485006043	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074485006044	Histidine kinase; Region: HisKA_3; pfam07730
1074485006045	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074485006046	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074485006047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074485006048	active site
1074485006049	phosphorylation site [posttranslational modification]
1074485006050	intermolecular recognition site; other site
1074485006051	dimerization interface [polypeptide binding]; other site
1074485006052	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074485006053	DNA binding residues [nucleotide binding]
1074485006054	dimerization interface [polypeptide binding]; other site
1074485006055	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1074485006056	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1074485006057	active site
1074485006058	trimer interface [polypeptide binding]; other site
1074485006059	allosteric site; other site
1074485006060	active site lid [active]
1074485006061	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1074485006062	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1074485006063	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1074485006064	active site
1074485006065	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1074485006066	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1074485006067	putative active site cavity [active]
1074485006068	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1074485006069	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1074485006070	nucleotide binding site [chemical binding]; other site
1074485006071	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1074485006072	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074485006073	DNA-binding site [nucleotide binding]; DNA binding site
1074485006074	FCD domain; Region: FCD; pfam07729
1074485006075	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074485006076	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1074485006077	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074485006078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485006079	dimer interface [polypeptide binding]; other site
1074485006080	conserved gate region; other site
1074485006081	putative PBP binding loops; other site
1074485006082	ABC-ATPase subunit interface; other site
1074485006083	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074485006084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074485006085	dimer interface [polypeptide binding]; other site
1074485006086	conserved gate region; other site
1074485006087	putative PBP binding loops; other site
1074485006088	ABC-ATPase subunit interface; other site
1074485006089	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1074485006090	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485006091	Walker A/P-loop; other site
1074485006092	ATP binding site [chemical binding]; other site
1074485006093	Q-loop/lid; other site
1074485006094	ABC transporter signature motif; other site
1074485006095	Walker B; other site
1074485006096	D-loop; other site
1074485006097	H-loop/switch region; other site
1074485006098	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1074485006099	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1074485006100	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074485006101	Walker A/P-loop; other site
1074485006102	ATP binding site [chemical binding]; other site
1074485006103	Q-loop/lid; other site
1074485006104	ABC transporter signature motif; other site
1074485006105	Walker B; other site
1074485006106	D-loop; other site
1074485006107	H-loop/switch region; other site
1074485006108	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074485006109	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1074485006110	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1074485006111	inhibitor site; inhibition site
1074485006112	active site
1074485006113	dimer interface [polypeptide binding]; other site
1074485006114	catalytic residue [active]
1074485006115	CAAX protease self-immunity; Region: Abi; pfam02517
1074485006116	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1074485006117	active site
1074485006118	catalytic residues [active]
1074485006119	choline-sulfatase; Region: chol_sulfatase; TIGR03417
1074485006120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1074485006121	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
1074485006122	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
1074485006123	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1074485006124	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074485006125	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1074485006126	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1074485006127	substrate binding pocket [chemical binding]; other site
1074485006128	substrate-Mg2+ binding site; other site
1074485006129	aspartate-rich region 1; other site
1074485006130	aspartate-rich region 2; other site
1074485006131	phytoene desaturase; Region: crtI_fam; TIGR02734
1074485006132	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074485006133	SdpI/YhfL protein family; Region: SdpI; pfam13630
1074485006134	anthranilate synthase component I; Provisional; Region: PRK13564
1074485006135	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1074485006136	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1074485006137	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1074485006138	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1074485006139	glutamine binding [chemical binding]; other site
1074485006140	catalytic triad [active]
1074485006141	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1074485006142	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1074485006143	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1074485006144	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1074485006145	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1074485006146	active site
1074485006147	ribulose/triose binding site [chemical binding]; other site
1074485006148	phosphate binding site [ion binding]; other site
1074485006149	substrate (anthranilate) binding pocket [chemical binding]; other site
1074485006150	product (indole) binding pocket [chemical binding]; other site
1074485006151	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1074485006152	active site
1074485006153	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1074485006154	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1074485006155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074485006156	catalytic residue [active]
1074485006157	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1074485006158	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1074485006159	substrate binding site [chemical binding]; other site
1074485006160	active site
1074485006161	catalytic residues [active]
1074485006162	heterodimer interface [polypeptide binding]; other site
1074485006163	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1074485006164	iron-sulfur cluster [ion binding]; other site
1074485006165	[2Fe-2S] cluster binding site [ion binding]; other site
1074485006166	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1074485006167	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1074485006168	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1074485006169	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1074485006170	hypothetical protein; Validated; Region: PRK00228
1074485006171	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1074485006172	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1074485006173	active site
1074485006174	NTP binding site [chemical binding]; other site
1074485006175	metal binding triad [ion binding]; metal-binding site
1074485006176	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1074485006177	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074485006178	Zn2+ binding site [ion binding]; other site
1074485006179	Mg2+ binding site [ion binding]; other site
1074485006180	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1074485006181	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1074485006182	active site
1074485006183	Ap6A binding site [chemical binding]; other site
1074485006184	nudix motif; other site
1074485006185	metal binding site [ion binding]; metal-binding site
1074485006186	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1074485006187	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1074485006188	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1074485006189	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074485006190	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074485006191	DNA binding residues [nucleotide binding]
1074485006192	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1074485006193	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074485006194	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074485006195	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1074485006196	catalytic residues [active]
1074485006197	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1074485006198	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1074485006199	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1074485006200	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1074485006201	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1074485006202	active site
1074485006203	metal binding site [ion binding]; metal-binding site
1074485006204	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1074485006205	ParB-like nuclease domain; Region: ParBc; pfam02195
1074485006206	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1074485006207	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1074485006208	P-loop; other site
1074485006209	Magnesium ion binding site [ion binding]; other site
1074485006210	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1074485006211	Magnesium ion binding site [ion binding]; other site
1074485006212	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1074485006213	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1074485006214	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
1074485006215	Haemolytic domain; Region: Haemolytic; pfam01809
1074485006216	ribonuclease P; Reviewed; Region: rnpA; PRK03459
1074485006217	Ribosomal protein L34; Region: Ribosomal_L34; cl00370