-- dump date 20140619_052403 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1087453000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1087453000003 Walker A motif; other site 1087453000004 ATP binding site [chemical binding]; other site 1087453000005 Walker B motif; other site 1087453000006 arginine finger; other site 1087453000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1087453000008 DnaA box-binding interface [nucleotide binding]; other site 1087453000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1087453000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1087453000011 putative DNA binding surface [nucleotide binding]; other site 1087453000012 dimer interface [polypeptide binding]; other site 1087453000013 beta-clamp/clamp loader binding surface; other site 1087453000014 beta-clamp/translesion DNA polymerase binding surface; other site 1087453000015 recombination protein F; Reviewed; Region: recF; PRK00064 1087453000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1087453000017 Walker A/P-loop; other site 1087453000018 ATP binding site [chemical binding]; other site 1087453000019 Q-loop/lid; other site 1087453000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453000021 ABC transporter signature motif; other site 1087453000022 Walker B; other site 1087453000023 D-loop; other site 1087453000024 H-loop/switch region; other site 1087453000025 hypothetical protein; Provisional; Region: PRK00111 1087453000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1087453000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453000028 ATP binding site [chemical binding]; other site 1087453000029 Mg2+ binding site [ion binding]; other site 1087453000030 G-X-G motif; other site 1087453000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1087453000032 anchoring element; other site 1087453000033 dimer interface [polypeptide binding]; other site 1087453000034 ATP binding site [chemical binding]; other site 1087453000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1087453000036 active site 1087453000037 putative metal-binding site [ion binding]; other site 1087453000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1087453000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1087453000040 metal binding site [ion binding]; metal-binding site 1087453000041 DNA gyrase subunit A; Validated; Region: PRK05560 1087453000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1087453000043 CAP-like domain; other site 1087453000044 active site 1087453000045 primary dimer interface [polypeptide binding]; other site 1087453000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087453000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087453000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087453000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087453000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087453000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087453000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1087453000053 YwiC-like protein; Region: YwiC; pfam14256 1087453000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1087453000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1087453000056 putative ligand binding site [chemical binding]; other site 1087453000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1087453000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1087453000059 TM-ABC transporter signature motif; other site 1087453000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1087453000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1087453000062 Walker A/P-loop; other site 1087453000063 ATP binding site [chemical binding]; other site 1087453000064 Q-loop/lid; other site 1087453000065 ABC transporter signature motif; other site 1087453000066 Walker B; other site 1087453000067 D-loop; other site 1087453000068 H-loop/switch region; other site 1087453000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1087453000070 active site 1087453000071 Rhomboid family; Region: Rhomboid; pfam01694 1087453000072 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 1087453000073 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1087453000074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1087453000075 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 1087453000076 putative active site [active] 1087453000077 catalytic site [active] 1087453000078 Mg binding site [ion binding]; other site 1087453000079 catalytic loop [active] 1087453000080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453000081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453000082 Walker A/P-loop; other site 1087453000083 ATP binding site [chemical binding]; other site 1087453000084 Q-loop/lid; other site 1087453000085 ABC transporter signature motif; other site 1087453000086 Walker B; other site 1087453000087 D-loop; other site 1087453000088 H-loop/switch region; other site 1087453000089 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1087453000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453000091 ABC-ATPase subunit interface; other site 1087453000092 dimer interface [polypeptide binding]; other site 1087453000093 putative PBP binding regions; other site 1087453000094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453000095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453000096 ABC-ATPase subunit interface; other site 1087453000097 dimer interface [polypeptide binding]; other site 1087453000098 putative PBP binding regions; other site 1087453000099 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1087453000100 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1087453000101 siderophore binding site; other site 1087453000102 putative septation inhibitor protein; Reviewed; Region: PRK00159 1087453000103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1087453000104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087453000105 active site 1087453000106 ATP binding site [chemical binding]; other site 1087453000107 substrate binding site [chemical binding]; other site 1087453000108 activation loop (A-loop); other site 1087453000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1087453000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453000111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453000112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453000113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453000114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1087453000115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087453000116 active site 1087453000117 ATP binding site [chemical binding]; other site 1087453000118 substrate binding site [chemical binding]; other site 1087453000119 activation loop (A-loop); other site 1087453000120 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1087453000121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1087453000122 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1087453000123 Protein phosphatase 2C; Region: PP2C; pfam00481 1087453000124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1087453000125 active site 1087453000126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1087453000127 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1087453000128 phosphopeptide binding site; other site 1087453000129 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1087453000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1087453000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1087453000132 phosphopeptide binding site; other site 1087453000133 CAAX protease self-immunity; Region: Abi; pfam02517 1087453000134 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1087453000135 Predicted transcriptional regulators [Transcription]; Region: COG1695 1087453000136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1087453000137 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1087453000138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453000139 intersubunit interface [polypeptide binding]; other site 1087453000140 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453000141 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453000142 Walker A/P-loop; other site 1087453000143 ATP binding site [chemical binding]; other site 1087453000144 Q-loop/lid; other site 1087453000145 ABC transporter signature motif; other site 1087453000146 Walker B; other site 1087453000147 D-loop; other site 1087453000148 H-loop/switch region; other site 1087453000149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453000150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453000151 ABC-ATPase subunit interface; other site 1087453000152 dimer interface [polypeptide binding]; other site 1087453000153 putative PBP binding regions; other site 1087453000154 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1087453000155 MgtE intracellular N domain; Region: MgtE_N; smart00924 1087453000156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1087453000157 Divalent cation transporter; Region: MgtE; pfam01769 1087453000158 trehalose synthase; Region: treS_nterm; TIGR02456 1087453000159 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 1087453000160 active site 1087453000161 catalytic site [active] 1087453000162 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1087453000163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453000164 putative substrate translocation pore; other site 1087453000165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453000166 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1087453000167 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1087453000168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453000169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453000170 DNA binding residues [nucleotide binding] 1087453000171 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1087453000172 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1087453000173 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1087453000174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087453000175 catalytic residues [active] 1087453000176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1087453000177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453000178 dimer interface [polypeptide binding]; other site 1087453000179 conserved gate region; other site 1087453000180 putative PBP binding loops; other site 1087453000181 ABC-ATPase subunit interface; other site 1087453000182 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1087453000183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453000184 Walker A/P-loop; other site 1087453000185 ATP binding site [chemical binding]; other site 1087453000186 Q-loop/lid; other site 1087453000187 ABC transporter signature motif; other site 1087453000188 Walker B; other site 1087453000189 D-loop; other site 1087453000190 H-loop/switch region; other site 1087453000191 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1087453000192 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1087453000193 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1087453000194 putative metal binding site [ion binding]; other site 1087453000195 biotin synthase; Validated; Region: PRK06256 1087453000196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453000197 FeS/SAM binding site; other site 1087453000198 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1087453000199 MepB protein; Region: MepB; cl01985 1087453000200 AMP nucleosidase; Provisional; Region: PRK08292 1087453000201 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1087453000202 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1087453000203 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1087453000204 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1087453000205 active site 1087453000206 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1087453000207 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1087453000208 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1087453000209 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1087453000210 Lipase (class 2); Region: Lipase_2; pfam01674 1087453000211 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1087453000212 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1087453000213 trimer interface [polypeptide binding]; other site 1087453000214 putative metal binding site [ion binding]; other site 1087453000215 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087453000216 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1087453000217 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1087453000218 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1087453000219 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1087453000220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453000221 Coenzyme A binding pocket [chemical binding]; other site 1087453000222 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1087453000223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1087453000224 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1087453000225 MarR family; Region: MarR; pfam01047 1087453000226 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1087453000227 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1087453000228 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1087453000229 hypothetical protein; Provisional; Region: PRK10621 1087453000230 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1087453000231 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1087453000232 active site 1087453000233 phosphorylation site [posttranslational modification] 1087453000234 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1087453000235 active site 1087453000236 P-loop; other site 1087453000237 phosphorylation site [posttranslational modification] 1087453000238 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1087453000239 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1087453000240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453000241 ATP binding site [chemical binding]; other site 1087453000242 putative Mg++ binding site [ion binding]; other site 1087453000243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453000244 nucleotide binding region [chemical binding]; other site 1087453000245 ATP-binding site [chemical binding]; other site 1087453000246 Helicase associated domain (HA2); Region: HA2; pfam04408 1087453000247 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1087453000248 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1087453000249 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1087453000250 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1087453000251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453000252 NAD(P) binding site [chemical binding]; other site 1087453000253 active site 1087453000254 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1087453000255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087453000256 RNA binding surface [nucleotide binding]; other site 1087453000257 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1087453000258 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087453000259 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1087453000260 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1087453000261 DNA binding site [nucleotide binding] 1087453000262 active site 1087453000263 glycerol kinase; Provisional; Region: glpK; PRK00047 1087453000264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1087453000265 nucleotide binding site [chemical binding]; other site 1087453000266 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1087453000267 amphipathic channel; other site 1087453000268 Asn-Pro-Ala signature motifs; other site 1087453000269 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1087453000270 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1087453000271 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1087453000272 active site 1087453000273 Zn binding site [ion binding]; other site 1087453000274 Protease prsW family; Region: PrsW-protease; pfam13367 1087453000275 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1087453000276 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1087453000277 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1087453000278 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1087453000279 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1087453000280 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1087453000281 classical (c) SDRs; Region: SDR_c; cd05233 1087453000282 NAD(P) binding site [chemical binding]; other site 1087453000283 active site 1087453000284 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1087453000285 FAD binding domain; Region: FAD_binding_4; pfam01565 1087453000286 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1087453000287 Predicted membrane protein [Function unknown]; Region: COG2246 1087453000288 GtrA-like protein; Region: GtrA; pfam04138 1087453000289 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1087453000290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1087453000291 active site 1087453000292 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1087453000293 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1087453000294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087453000295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087453000296 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087453000297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453000298 ABC-ATPase subunit interface; other site 1087453000299 dimer interface [polypeptide binding]; other site 1087453000300 putative PBP binding regions; other site 1087453000301 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453000302 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1087453000303 intersubunit interface [polypeptide binding]; other site 1087453000304 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1087453000305 active site 1087453000306 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1087453000307 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1087453000308 Walker A/P-loop; other site 1087453000309 ATP binding site [chemical binding]; other site 1087453000310 Q-loop/lid; other site 1087453000311 ABC transporter signature motif; other site 1087453000312 Walker B; other site 1087453000313 D-loop; other site 1087453000314 H-loop/switch region; other site 1087453000315 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1087453000316 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1087453000317 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1087453000318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1087453000319 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1087453000320 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1087453000321 NAD(P) binding site [chemical binding]; other site 1087453000322 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1087453000323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087453000324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453000325 homodimer interface [polypeptide binding]; other site 1087453000326 catalytic residue [active] 1087453000327 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1087453000328 transmembrane helices; other site 1087453000329 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1087453000330 CAT RNA binding domain; Region: CAT_RBD; smart01061 1087453000331 PRD domain; Region: PRD; pfam00874 1087453000332 PRD domain; Region: PRD; pfam00874 1087453000333 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1087453000334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087453000335 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1087453000336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087453000337 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1087453000338 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1087453000339 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1087453000340 active site 1087453000341 multimer interface [polypeptide binding]; other site 1087453000342 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1087453000343 predicted active site [active] 1087453000344 catalytic triad [active] 1087453000345 prephenate dehydrogenase; Validated; Region: PRK06545 1087453000346 prephenate dehydrogenase; Validated; Region: PRK08507 1087453000347 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1087453000348 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1087453000349 nucleoside/Zn binding site; other site 1087453000350 dimer interface [polypeptide binding]; other site 1087453000351 catalytic motif [active] 1087453000352 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1087453000353 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1087453000354 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1087453000355 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1087453000356 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1087453000357 active site 1087453000358 KMSKS motif; other site 1087453000359 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1087453000360 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1087453000361 Shikimate kinase; Region: SKI; pfam01202 1087453000362 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1087453000363 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1087453000364 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1087453000365 putative NAD(P) binding site [chemical binding]; other site 1087453000366 catalytic Zn binding site [ion binding]; other site 1087453000367 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1087453000368 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1087453000369 NADP binding site [chemical binding]; other site 1087453000370 homodimer interface [polypeptide binding]; other site 1087453000371 active site 1087453000372 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1087453000373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087453000374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453000375 homodimer interface [polypeptide binding]; other site 1087453000376 catalytic residue [active] 1087453000377 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1087453000378 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1087453000379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453000380 Walker A motif; other site 1087453000381 ATP binding site [chemical binding]; other site 1087453000382 Walker B motif; other site 1087453000383 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1087453000384 arginine finger; other site 1087453000385 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1087453000386 hypothetical protein; Validated; Region: PRK00153 1087453000387 recombination protein RecR; Reviewed; Region: recR; PRK00076 1087453000388 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1087453000389 RecR protein; Region: RecR; pfam02132 1087453000390 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1087453000391 putative active site [active] 1087453000392 putative metal-binding site [ion binding]; other site 1087453000393 tetramer interface [polypeptide binding]; other site 1087453000394 putative transporter; Provisional; Region: PRK09821 1087453000395 GntP family permease; Region: GntP_permease; pfam02447 1087453000396 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1087453000397 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1087453000398 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1087453000399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087453000400 DNA-binding site [nucleotide binding]; DNA binding site 1087453000401 FCD domain; Region: FCD; pfam07729 1087453000402 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1087453000403 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1087453000404 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1087453000405 catalytic triad [active] 1087453000406 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1087453000407 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453000408 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1087453000409 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1087453000410 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1087453000411 active site 1087453000412 catalytic site [active] 1087453000413 substrate binding site [chemical binding]; other site 1087453000414 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1087453000415 2-isopropylmalate synthase; Validated; Region: PRK03739 1087453000416 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1087453000417 active site 1087453000418 catalytic residues [active] 1087453000419 metal binding site [ion binding]; metal-binding site 1087453000420 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1087453000421 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1087453000422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453000423 DNA binding residues [nucleotide binding] 1087453000424 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1087453000425 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1087453000426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453000427 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453000428 putative substrate translocation pore; other site 1087453000429 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1087453000430 intersubunit interface [polypeptide binding]; other site 1087453000431 active site 1087453000432 catalytic residue [active] 1087453000433 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1087453000434 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1087453000435 active site 1087453000436 substrate binding site [chemical binding]; other site 1087453000437 metal binding site [ion binding]; metal-binding site 1087453000438 TQXA domain; Region: TQXA_dom; TIGR03934 1087453000439 Cna protein B-type domain; Region: Cna_B; pfam05738 1087453000440 Cna protein B-type domain; Region: Cna_B; pfam05738 1087453000441 Cna protein B-type domain; Region: Cna_B; pfam05738 1087453000442 aspartate kinase; Reviewed; Region: PRK06635 1087453000443 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1087453000444 putative nucleotide binding site [chemical binding]; other site 1087453000445 putative catalytic residues [active] 1087453000446 putative Mg ion binding site [ion binding]; other site 1087453000447 putative aspartate binding site [chemical binding]; other site 1087453000448 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1087453000449 putative allosteric regulatory site; other site 1087453000450 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1087453000451 putative allosteric regulatory residue; other site 1087453000452 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1087453000453 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1087453000454 RNA polymerase sigma factor; Provisional; Region: PRK12535 1087453000455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453000456 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1087453000457 DNA binding residues [nucleotide binding] 1087453000458 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1087453000459 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1087453000460 heme binding pocket [chemical binding]; other site 1087453000461 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 1087453000462 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1087453000463 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1087453000464 Walker A/P-loop; other site 1087453000465 ATP binding site [chemical binding]; other site 1087453000466 Q-loop/lid; other site 1087453000467 ABC transporter signature motif; other site 1087453000468 Walker B; other site 1087453000469 D-loop; other site 1087453000470 H-loop/switch region; other site 1087453000471 TOBE domain; Region: TOBE_2; pfam08402 1087453000472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453000473 dimer interface [polypeptide binding]; other site 1087453000474 conserved gate region; other site 1087453000475 ABC-ATPase subunit interface; other site 1087453000476 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1087453000477 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1087453000478 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1087453000479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453000480 putative substrate translocation pore; other site 1087453000481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087453000482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453000483 active site 1087453000484 phosphorylation site [posttranslational modification] 1087453000485 intermolecular recognition site; other site 1087453000486 dimerization interface [polypeptide binding]; other site 1087453000487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087453000488 DNA binding site [nucleotide binding] 1087453000489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087453000490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087453000491 dimer interface [polypeptide binding]; other site 1087453000492 phosphorylation site [posttranslational modification] 1087453000493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453000494 ATP binding site [chemical binding]; other site 1087453000495 Mg2+ binding site [ion binding]; other site 1087453000496 G-X-G motif; other site 1087453000497 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1087453000498 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1087453000499 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1087453000500 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1087453000501 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087453000502 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1087453000503 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1087453000504 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087453000505 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1087453000506 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1087453000507 Predicted membrane protein [Function unknown]; Region: COG1511 1087453000508 Predicted membrane protein [Function unknown]; Region: COG1511 1087453000509 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1087453000510 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1087453000511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453000512 ABC transporter; Region: ABC_tran; pfam00005 1087453000513 Q-loop/lid; other site 1087453000514 ABC transporter signature motif; other site 1087453000515 Walker B; other site 1087453000516 D-loop; other site 1087453000517 H-loop/switch region; other site 1087453000518 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1087453000519 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1087453000520 putative active site [active] 1087453000521 putative metal binding site [ion binding]; other site 1087453000522 Yqey-like protein; Region: YqeY; pfam09424 1087453000523 Transglycosylase; Region: Transgly; pfam00912 1087453000524 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1087453000525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1087453000526 PASTA domain; Region: PASTA; pfam03793 1087453000527 Transcription factor WhiB; Region: Whib; pfam02467 1087453000528 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1087453000529 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1087453000530 homotrimer interaction site [polypeptide binding]; other site 1087453000531 putative active site [active] 1087453000532 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1087453000533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1087453000534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1087453000535 ligand binding site [chemical binding]; other site 1087453000536 flexible hinge region; other site 1087453000537 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1087453000538 putative switch regulator; other site 1087453000539 non-specific DNA interactions [nucleotide binding]; other site 1087453000540 DNA binding site [nucleotide binding] 1087453000541 sequence specific DNA binding site [nucleotide binding]; other site 1087453000542 putative cAMP binding site [chemical binding]; other site 1087453000543 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1087453000544 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1087453000545 minor groove reading motif; other site 1087453000546 helix-hairpin-helix signature motif; other site 1087453000547 substrate binding pocket [chemical binding]; other site 1087453000548 active site 1087453000549 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1087453000550 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1087453000551 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087453000552 catalytic residues [active] 1087453000553 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1087453000554 putative active site [active] 1087453000555 putative CoA binding site [chemical binding]; other site 1087453000556 nudix motif; other site 1087453000557 metal binding site [ion binding]; metal-binding site 1087453000558 Colicin V production protein; Region: Colicin_V; pfam02674 1087453000559 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1087453000560 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1087453000561 active site 1087453000562 substrate binding sites [chemical binding]; other site 1087453000563 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1087453000564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087453000565 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1087453000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453000567 motif II; other site 1087453000568 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1087453000569 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1087453000570 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1087453000571 ATP binding site [chemical binding]; other site 1087453000572 Walker A motif; other site 1087453000573 hexamer interface [polypeptide binding]; other site 1087453000574 Walker B motif; other site 1087453000575 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1087453000576 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1087453000577 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1087453000578 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1087453000579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453000580 ATP binding site [chemical binding]; other site 1087453000581 putative Mg++ binding site [ion binding]; other site 1087453000582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453000583 nucleotide binding region [chemical binding]; other site 1087453000584 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1087453000585 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1087453000586 DNA-binding site [nucleotide binding]; DNA binding site 1087453000587 RNA-binding motif; other site 1087453000588 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1087453000589 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1087453000590 active site 1087453000591 interdomain interaction site; other site 1087453000592 putative metal-binding site [ion binding]; other site 1087453000593 nucleotide binding site [chemical binding]; other site 1087453000594 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1087453000595 domain I; other site 1087453000596 DNA binding groove [nucleotide binding] 1087453000597 phosphate binding site [ion binding]; other site 1087453000598 domain II; other site 1087453000599 domain III; other site 1087453000600 nucleotide binding site [chemical binding]; other site 1087453000601 catalytic site [active] 1087453000602 domain IV; other site 1087453000603 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1087453000604 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1087453000605 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1087453000606 Predicted membrane protein [Function unknown]; Region: COG1297 1087453000607 putative oligopeptide transporter, OPT family; Region: TIGR00733 1087453000608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087453000609 dimerization interface [polypeptide binding]; other site 1087453000610 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1087453000611 cyclase homology domain; Region: CHD; cd07302 1087453000612 nucleotidyl binding site; other site 1087453000613 metal binding site [ion binding]; metal-binding site 1087453000614 dimer interface [polypeptide binding]; other site 1087453000615 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1087453000616 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1087453000617 acyl-CoA synthetase; Validated; Region: PRK07788 1087453000618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453000619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453000620 acyl-activating enzyme (AAE) consensus motif; other site 1087453000621 acyl-activating enzyme (AAE) consensus motif; other site 1087453000622 AMP binding site [chemical binding]; other site 1087453000623 active site 1087453000624 CoA binding site [chemical binding]; other site 1087453000625 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1087453000626 active site 1087453000627 catalytic triad [active] 1087453000628 oxyanion hole [active] 1087453000629 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1087453000630 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1087453000631 substrate binding site; other site 1087453000632 tetramer interface; other site 1087453000633 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1087453000634 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1087453000635 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1087453000636 NADP binding site [chemical binding]; other site 1087453000637 active site 1087453000638 putative substrate binding site [chemical binding]; other site 1087453000639 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1087453000640 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1087453000641 NAD binding site [chemical binding]; other site 1087453000642 substrate binding site [chemical binding]; other site 1087453000643 homodimer interface [polypeptide binding]; other site 1087453000644 active site 1087453000645 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1087453000646 Zn binding site [ion binding]; other site 1087453000647 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1087453000648 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1087453000649 Putative esterase; Region: Esterase; pfam00756 1087453000650 Peptidase family S64; Region: Peptidase_S64; pfam08192 1087453000651 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1087453000652 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1087453000653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087453000654 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1087453000655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1087453000656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1087453000657 non-specific DNA binding site [nucleotide binding]; other site 1087453000658 salt bridge; other site 1087453000659 sequence-specific DNA binding site [nucleotide binding]; other site 1087453000660 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1087453000661 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1087453000662 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1087453000663 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1087453000664 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1087453000665 putative Iron-sulfur protein interface [polypeptide binding]; other site 1087453000666 proximal heme binding site [chemical binding]; other site 1087453000667 distal heme binding site [chemical binding]; other site 1087453000668 putative dimer interface [polypeptide binding]; other site 1087453000669 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1087453000670 L-aspartate oxidase; Provisional; Region: PRK06175 1087453000671 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1087453000672 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1087453000673 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1087453000674 Predicted membrane protein [Function unknown]; Region: COG2733 1087453000675 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1087453000676 Class I aldolases; Region: Aldolase_Class_I; cl17187 1087453000677 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1087453000678 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1087453000679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453000680 FeS/SAM binding site; other site 1087453000681 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1087453000682 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1087453000683 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1087453000684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1087453000685 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1087453000686 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1087453000687 FAD binding domain; Region: FAD_binding_4; pfam01565 1087453000688 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1087453000689 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1087453000690 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1087453000691 acyl-activating enzyme (AAE) consensus motif; other site 1087453000692 putative AMP binding site [chemical binding]; other site 1087453000693 putative active site [active] 1087453000694 putative CoA binding site [chemical binding]; other site 1087453000695 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1087453000696 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1087453000697 putative ADP-binding pocket [chemical binding]; other site 1087453000698 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453000699 catalytic core [active] 1087453000700 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453000701 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1087453000702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087453000703 dimer interface [polypeptide binding]; other site 1087453000704 phosphorylation site [posttranslational modification] 1087453000705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453000706 ATP binding site [chemical binding]; other site 1087453000707 Mg2+ binding site [ion binding]; other site 1087453000708 G-X-G motif; other site 1087453000709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087453000710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453000711 active site 1087453000712 phosphorylation site [posttranslational modification] 1087453000713 intermolecular recognition site; other site 1087453000714 dimerization interface [polypeptide binding]; other site 1087453000715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087453000716 DNA binding site [nucleotide binding] 1087453000717 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1087453000718 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1087453000719 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1087453000720 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1087453000721 DNA binding domain, excisionase family; Region: excise; TIGR01764 1087453000722 Thioredoxin; Region: Thioredoxin_4; cl17273 1087453000723 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1087453000724 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1087453000725 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1087453000726 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1087453000727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453000728 motif II; other site 1087453000729 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1087453000730 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1087453000731 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1087453000732 tRNA; other site 1087453000733 putative tRNA binding site [nucleotide binding]; other site 1087453000734 putative NADP binding site [chemical binding]; other site 1087453000735 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1087453000736 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1087453000737 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1087453000738 domain interfaces; other site 1087453000739 active site 1087453000740 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1087453000741 active site 1087453000742 homodimer interface [polypeptide binding]; other site 1087453000743 SAM binding site [chemical binding]; other site 1087453000744 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1087453000745 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1087453000746 active site 1087453000747 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1087453000748 dimer interface [polypeptide binding]; other site 1087453000749 active site 1087453000750 Schiff base residues; other site 1087453000751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1087453000752 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1087453000753 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1087453000754 substrate binding site [chemical binding]; other site 1087453000755 active site 1087453000756 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1087453000757 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1087453000758 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1087453000759 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1087453000760 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1087453000761 inhibitor-cofactor binding pocket; inhibition site 1087453000762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453000763 catalytic residue [active] 1087453000764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453000765 catalytic core [active] 1087453000766 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1087453000767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087453000768 catalytic residues [active] 1087453000769 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1087453000770 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1087453000771 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1087453000772 ResB-like family; Region: ResB; pfam05140 1087453000773 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1087453000774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453000775 S-adenosylmethionine binding site [chemical binding]; other site 1087453000776 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453000777 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453000778 Walker A/P-loop; other site 1087453000779 ATP binding site [chemical binding]; other site 1087453000780 Q-loop/lid; other site 1087453000781 ABC transporter signature motif; other site 1087453000782 Walker B; other site 1087453000783 D-loop; other site 1087453000784 H-loop/switch region; other site 1087453000785 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1087453000786 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453000787 intersubunit interface [polypeptide binding]; other site 1087453000788 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1087453000789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453000790 ABC-ATPase subunit interface; other site 1087453000791 dimer interface [polypeptide binding]; other site 1087453000792 putative PBP binding regions; other site 1087453000793 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1087453000794 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1087453000795 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1087453000796 UbiA prenyltransferase family; Region: UbiA; pfam01040 1087453000797 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1087453000798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453000799 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453000800 acyl-activating enzyme (AAE) consensus motif; other site 1087453000801 acyl-activating enzyme (AAE) consensus motif; other site 1087453000802 AMP binding site [chemical binding]; other site 1087453000803 active site 1087453000804 CoA binding site [chemical binding]; other site 1087453000805 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1087453000806 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1087453000807 substrate binding site [chemical binding]; other site 1087453000808 oxyanion hole (OAH) forming residues; other site 1087453000809 trimer interface [polypeptide binding]; other site 1087453000810 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1087453000811 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1087453000812 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1087453000813 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1087453000814 active site 1087453000815 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1087453000816 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1087453000817 dimer interface [polypeptide binding]; other site 1087453000818 tetramer interface [polypeptide binding]; other site 1087453000819 PYR/PP interface [polypeptide binding]; other site 1087453000820 TPP binding site [chemical binding]; other site 1087453000821 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1087453000822 TPP-binding site; other site 1087453000823 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1087453000824 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087453000825 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1087453000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453000827 S-adenosylmethionine binding site [chemical binding]; other site 1087453000828 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1087453000829 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1087453000830 NAD(P) binding site [chemical binding]; other site 1087453000831 LDH/MDH dimer interface [polypeptide binding]; other site 1087453000832 substrate binding site [chemical binding]; other site 1087453000833 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1087453000834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087453000835 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1087453000836 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1087453000837 substrate binding pocket [chemical binding]; other site 1087453000838 chain length determination region; other site 1087453000839 substrate-Mg2+ binding site; other site 1087453000840 catalytic residues [active] 1087453000841 aspartate-rich region 1; other site 1087453000842 active site lid residues [active] 1087453000843 aspartate-rich region 2; other site 1087453000844 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1087453000845 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1087453000846 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1087453000847 putative homodimer interface [polypeptide binding]; other site 1087453000848 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1087453000849 heterodimer interface [polypeptide binding]; other site 1087453000850 homodimer interface [polypeptide binding]; other site 1087453000851 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1087453000852 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1087453000853 23S rRNA interface [nucleotide binding]; other site 1087453000854 L7/L12 interface [polypeptide binding]; other site 1087453000855 putative thiostrepton binding site; other site 1087453000856 L25 interface [polypeptide binding]; other site 1087453000857 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1087453000858 mRNA/rRNA interface [nucleotide binding]; other site 1087453000859 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1087453000860 trimer interface [polypeptide binding]; other site 1087453000861 active site 1087453000862 G bulge; other site 1087453000863 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1087453000864 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1087453000865 FMN binding site [chemical binding]; other site 1087453000866 active site 1087453000867 substrate binding site [chemical binding]; other site 1087453000868 catalytic residue [active] 1087453000869 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1087453000870 23S rRNA interface [nucleotide binding]; other site 1087453000871 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1087453000872 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 1087453000873 L11 interface [polypeptide binding]; other site 1087453000874 putative EF-Tu interaction site [polypeptide binding]; other site 1087453000875 putative EF-G interaction site [polypeptide binding]; other site 1087453000876 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453000877 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1087453000878 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453000879 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453000880 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453000881 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453000882 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1087453000883 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1087453000884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087453000885 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087453000886 ABC-ATPase subunit interface; other site 1087453000887 dimer interface [polypeptide binding]; other site 1087453000888 putative PBP binding regions; other site 1087453000889 Ethylene insensitive 3; Region: EIN3; cl04813 1087453000890 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1087453000891 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1087453000892 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1087453000893 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1087453000894 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1087453000895 RPB1 interaction site [polypeptide binding]; other site 1087453000896 RPB10 interaction site [polypeptide binding]; other site 1087453000897 RPB11 interaction site [polypeptide binding]; other site 1087453000898 RPB3 interaction site [polypeptide binding]; other site 1087453000899 RPB12 interaction site [polypeptide binding]; other site 1087453000900 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1087453000901 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1087453000902 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1087453000903 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1087453000904 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1087453000905 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1087453000906 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1087453000907 G-loop; other site 1087453000908 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1087453000909 DNA binding site [nucleotide binding] 1087453000910 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1087453000911 Histidine kinase; Region: HisKA_3; pfam07730 1087453000912 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087453000913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087453000914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453000915 active site 1087453000916 phosphorylation site [posttranslational modification] 1087453000917 intermolecular recognition site; other site 1087453000918 dimerization interface [polypeptide binding]; other site 1087453000919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087453000920 DNA binding residues [nucleotide binding] 1087453000921 dimerization interface [polypeptide binding]; other site 1087453000922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087453000923 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1087453000924 Walker A/P-loop; other site 1087453000925 ATP binding site [chemical binding]; other site 1087453000926 Q-loop/lid; other site 1087453000927 ABC transporter signature motif; other site 1087453000928 Walker B; other site 1087453000929 D-loop; other site 1087453000930 H-loop/switch region; other site 1087453000931 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1087453000932 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1087453000933 TIGR03943 family protein; Region: TIGR03943 1087453000934 Predicted permease; Region: DUF318; cl17795 1087453000935 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1087453000936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453000937 FeS/SAM binding site; other site 1087453000938 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1087453000939 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1087453000940 effector binding site; other site 1087453000941 active site 1087453000942 Zn binding site [ion binding]; other site 1087453000943 glycine loop; other site 1087453000944 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1087453000945 S17 interaction site [polypeptide binding]; other site 1087453000946 S8 interaction site; other site 1087453000947 16S rRNA interaction site [nucleotide binding]; other site 1087453000948 streptomycin interaction site [chemical binding]; other site 1087453000949 23S rRNA interaction site [nucleotide binding]; other site 1087453000950 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1087453000951 30S ribosomal protein S7; Validated; Region: PRK05302 1087453000952 elongation factor G; Reviewed; Region: PRK00007 1087453000953 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1087453000954 G1 box; other site 1087453000955 putative GEF interaction site [polypeptide binding]; other site 1087453000956 GTP/Mg2+ binding site [chemical binding]; other site 1087453000957 Switch I region; other site 1087453000958 G2 box; other site 1087453000959 G3 box; other site 1087453000960 Switch II region; other site 1087453000961 G4 box; other site 1087453000962 G5 box; other site 1087453000963 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1087453000964 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1087453000965 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1087453000966 elongation factor Tu; Reviewed; Region: PRK00049 1087453000967 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1087453000968 G1 box; other site 1087453000969 GEF interaction site [polypeptide binding]; other site 1087453000970 GTP/Mg2+ binding site [chemical binding]; other site 1087453000971 Switch I region; other site 1087453000972 G2 box; other site 1087453000973 G3 box; other site 1087453000974 Switch II region; other site 1087453000975 G4 box; other site 1087453000976 G5 box; other site 1087453000977 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1087453000978 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1087453000979 Antibiotic Binding Site [chemical binding]; other site 1087453000980 Asp23 family; Region: Asp23; cl00574 1087453000981 Asp23 family; Region: Asp23; cl00574 1087453000982 Asp23 family; Region: Asp23; pfam03780 1087453000983 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1087453000984 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1087453000985 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1087453000986 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1087453000987 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1087453000988 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1087453000989 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1087453000990 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1087453000991 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1087453000992 putative translocon binding site; other site 1087453000993 protein-rRNA interface [nucleotide binding]; other site 1087453000994 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1087453000995 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1087453000996 G-X-X-G motif; other site 1087453000997 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1087453000998 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1087453000999 23S rRNA interface [nucleotide binding]; other site 1087453001000 5S rRNA interface [nucleotide binding]; other site 1087453001001 putative antibiotic binding site [chemical binding]; other site 1087453001002 L25 interface [polypeptide binding]; other site 1087453001003 L27 interface [polypeptide binding]; other site 1087453001004 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1087453001005 putative translocon interaction site; other site 1087453001006 23S rRNA interface [nucleotide binding]; other site 1087453001007 signal recognition particle (SRP54) interaction site; other site 1087453001008 L23 interface [polypeptide binding]; other site 1087453001009 trigger factor interaction site; other site 1087453001010 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1087453001011 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1087453001012 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1087453001013 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1087453001014 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453001015 Walker A/P-loop; other site 1087453001016 ATP binding site [chemical binding]; other site 1087453001017 Q-loop/lid; other site 1087453001018 ABC transporter signature motif; other site 1087453001019 Walker B; other site 1087453001020 D-loop; other site 1087453001021 H-loop/switch region; other site 1087453001022 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453001023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453001024 Walker A/P-loop; other site 1087453001025 ATP binding site [chemical binding]; other site 1087453001026 Q-loop/lid; other site 1087453001027 ABC transporter signature motif; other site 1087453001028 Walker B; other site 1087453001029 D-loop; other site 1087453001030 H-loop/switch region; other site 1087453001031 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453001032 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1087453001033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001034 dimer interface [polypeptide binding]; other site 1087453001035 conserved gate region; other site 1087453001036 putative PBP binding loops; other site 1087453001037 ABC-ATPase subunit interface; other site 1087453001038 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453001039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001040 putative PBP binding loops; other site 1087453001041 dimer interface [polypeptide binding]; other site 1087453001042 ABC-ATPase subunit interface; other site 1087453001043 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1087453001044 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1087453001045 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1087453001046 RNA binding site [nucleotide binding]; other site 1087453001047 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1087453001048 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1087453001049 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1087453001050 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1087453001051 serine transporter; Region: stp; TIGR00814 1087453001052 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1087453001053 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1087453001054 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1087453001055 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1087453001056 active site 1087453001057 homotetramer interface [polypeptide binding]; other site 1087453001058 homodimer interface [polypeptide binding]; other site 1087453001059 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1087453001060 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1087453001061 active site 1087453001062 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1087453001063 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1087453001064 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1087453001065 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1087453001066 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1087453001067 5S rRNA interface [nucleotide binding]; other site 1087453001068 23S rRNA interface [nucleotide binding]; other site 1087453001069 L5 interface [polypeptide binding]; other site 1087453001070 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1087453001071 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1087453001072 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1087453001073 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1087453001074 23S rRNA binding site [nucleotide binding]; other site 1087453001075 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1087453001076 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1087453001077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1087453001078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001079 dimer interface [polypeptide binding]; other site 1087453001080 conserved gate region; other site 1087453001081 putative PBP binding loops; other site 1087453001082 ABC-ATPase subunit interface; other site 1087453001083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1087453001084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001085 dimer interface [polypeptide binding]; other site 1087453001086 conserved gate region; other site 1087453001087 putative PBP binding loops; other site 1087453001088 ABC-ATPase subunit interface; other site 1087453001089 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1087453001090 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1087453001091 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1087453001092 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1087453001093 Walker A/P-loop; other site 1087453001094 ATP binding site [chemical binding]; other site 1087453001095 Q-loop/lid; other site 1087453001096 ABC transporter signature motif; other site 1087453001097 Walker B; other site 1087453001098 D-loop; other site 1087453001099 H-loop/switch region; other site 1087453001100 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1087453001101 SecY translocase; Region: SecY; pfam00344 1087453001102 adenylate kinase; Reviewed; Region: adk; PRK00279 1087453001103 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1087453001104 AMP-binding site [chemical binding]; other site 1087453001105 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1087453001106 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1087453001107 catalytic site [active] 1087453001108 BNR repeat-like domain; Region: BNR_2; pfam13088 1087453001109 Asp-box motif; other site 1087453001110 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1087453001111 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1087453001112 rRNA binding site [nucleotide binding]; other site 1087453001113 predicted 30S ribosome binding site; other site 1087453001114 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1087453001115 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1087453001116 30S ribosomal protein S11; Validated; Region: PRK05309 1087453001117 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1087453001118 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1087453001119 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087453001120 RNA binding surface [nucleotide binding]; other site 1087453001121 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1087453001122 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1087453001123 alphaNTD - beta interaction site [polypeptide binding]; other site 1087453001124 alphaNTD homodimer interface [polypeptide binding]; other site 1087453001125 alphaNTD - beta' interaction site [polypeptide binding]; other site 1087453001126 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1087453001127 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1087453001128 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1087453001129 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1087453001130 dimerization interface 3.5A [polypeptide binding]; other site 1087453001131 active site 1087453001132 Protein of unknown function (DUF690); Region: DUF690; cl04939 1087453001133 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1087453001134 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1087453001135 active site 1087453001136 catalytic residues [active] 1087453001137 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1087453001138 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1087453001139 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1087453001140 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1087453001141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453001142 Walker A/P-loop; other site 1087453001143 ATP binding site [chemical binding]; other site 1087453001144 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1087453001145 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1087453001146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1087453001147 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1087453001148 23S rRNA interface [nucleotide binding]; other site 1087453001149 L3 interface [polypeptide binding]; other site 1087453001150 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1087453001151 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1087453001152 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1087453001153 active site 1087453001154 substrate binding site [chemical binding]; other site 1087453001155 metal binding site [ion binding]; metal-binding site 1087453001156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1087453001157 alanine racemase; Reviewed; Region: alr; PRK00053 1087453001158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1087453001159 active site 1087453001160 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087453001161 dimer interface [polypeptide binding]; other site 1087453001162 substrate binding site [chemical binding]; other site 1087453001163 catalytic residues [active] 1087453001164 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1087453001165 Predicted permease [General function prediction only]; Region: COG2985 1087453001166 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1087453001167 TrkA-C domain; Region: TrkA_C; pfam02080 1087453001168 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1087453001169 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1087453001170 Glycoprotease family; Region: Peptidase_M22; pfam00814 1087453001171 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1087453001172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453001173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1087453001174 Coenzyme A binding pocket [chemical binding]; other site 1087453001175 UGMP family protein; Validated; Region: PRK09604 1087453001176 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1087453001177 oligomerisation interface [polypeptide binding]; other site 1087453001178 mobile loop; other site 1087453001179 roof hairpin; other site 1087453001180 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1087453001181 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1087453001182 ring oligomerisation interface [polypeptide binding]; other site 1087453001183 ATP/Mg binding site [chemical binding]; other site 1087453001184 stacking interactions; other site 1087453001185 hinge regions; other site 1087453001186 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1087453001187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453001188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453001189 DNA binding residues [nucleotide binding] 1087453001190 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1087453001191 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1087453001192 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1087453001193 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1087453001194 active site 1087453001195 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1087453001196 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1087453001197 phosphate binding site [ion binding]; other site 1087453001198 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1087453001199 GMP synthase; Reviewed; Region: guaA; PRK00074 1087453001200 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1087453001201 AMP/PPi binding site [chemical binding]; other site 1087453001202 candidate oxyanion hole; other site 1087453001203 catalytic triad [active] 1087453001204 potential glutamine specificity residues [chemical binding]; other site 1087453001205 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1087453001206 ATP Binding subdomain [chemical binding]; other site 1087453001207 Ligand Binding sites [chemical binding]; other site 1087453001208 Dimerization subdomain; other site 1087453001209 PspC domain; Region: PspC; cl00864 1087453001210 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1087453001211 PspC domain; Region: PspC; pfam04024 1087453001212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087453001213 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087453001214 ATP binding site [chemical binding]; other site 1087453001215 Mg2+ binding site [ion binding]; other site 1087453001216 G-X-G motif; other site 1087453001217 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087453001218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453001219 active site 1087453001220 phosphorylation site [posttranslational modification] 1087453001221 intermolecular recognition site; other site 1087453001222 dimerization interface [polypeptide binding]; other site 1087453001223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087453001224 dimerization interface [polypeptide binding]; other site 1087453001225 DNA binding residues [nucleotide binding] 1087453001226 AMIN domain; Region: AMIN; pfam11741 1087453001227 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1087453001228 putative dimer interface [polypeptide binding]; other site 1087453001229 putative [2Fe-2S] cluster binding site [ion binding]; other site 1087453001230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001231 dimer interface [polypeptide binding]; other site 1087453001232 conserved gate region; other site 1087453001233 ABC-ATPase subunit interface; other site 1087453001234 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1087453001235 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1087453001236 Walker A/P-loop; other site 1087453001237 ATP binding site [chemical binding]; other site 1087453001238 Q-loop/lid; other site 1087453001239 ABC transporter signature motif; other site 1087453001240 Walker B; other site 1087453001241 D-loop; other site 1087453001242 H-loop/switch region; other site 1087453001243 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1087453001244 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1087453001245 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1087453001246 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1087453001247 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453001248 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1087453001249 intersubunit interface [polypeptide binding]; other site 1087453001250 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1087453001251 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1087453001252 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087453001253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453001254 ABC-ATPase subunit interface; other site 1087453001255 dimer interface [polypeptide binding]; other site 1087453001256 putative PBP binding regions; other site 1087453001257 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087453001258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087453001259 ABC-ATPase subunit interface; other site 1087453001260 dimer interface [polypeptide binding]; other site 1087453001261 putative PBP binding regions; other site 1087453001262 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1087453001263 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1087453001264 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1087453001265 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1087453001266 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1087453001267 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1087453001268 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1087453001269 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1087453001270 homodimer interface [polypeptide binding]; other site 1087453001271 NADP binding site [chemical binding]; other site 1087453001272 substrate binding site [chemical binding]; other site 1087453001273 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1087453001274 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087453001275 active site 1087453001276 Htaa; Region: HtaA; pfam04213 1087453001277 Htaa; Region: HtaA; pfam04213 1087453001278 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1087453001279 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453001280 intersubunit interface [polypeptide binding]; other site 1087453001281 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453001282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453001283 ABC-ATPase subunit interface; other site 1087453001284 dimer interface [polypeptide binding]; other site 1087453001285 putative PBP binding regions; other site 1087453001286 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1087453001287 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453001288 Walker A/P-loop; other site 1087453001289 ATP binding site [chemical binding]; other site 1087453001290 Q-loop/lid; other site 1087453001291 ABC transporter signature motif; other site 1087453001292 Walker B; other site 1087453001293 D-loop; other site 1087453001294 H-loop/switch region; other site 1087453001295 Htaa; Region: HtaA; pfam04213 1087453001296 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1087453001297 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1087453001298 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1087453001299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453001300 putative substrate translocation pore; other site 1087453001301 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1087453001302 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1087453001303 DNA binding residues [nucleotide binding] 1087453001304 dimer interface [polypeptide binding]; other site 1087453001305 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1087453001306 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1087453001307 putative catalytic site [active] 1087453001308 putative metal binding site [ion binding]; other site 1087453001309 putative phosphate binding site [ion binding]; other site 1087453001310 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1087453001311 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1087453001312 active site 1087453001313 HIGH motif; other site 1087453001314 dimer interface [polypeptide binding]; other site 1087453001315 KMSKS motif; other site 1087453001316 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1087453001317 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1087453001318 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1087453001319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1087453001320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453001321 active site 1087453001322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1087453001323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1087453001324 non-specific DNA binding site [nucleotide binding]; other site 1087453001325 salt bridge; other site 1087453001326 sequence-specific DNA binding site [nucleotide binding]; other site 1087453001327 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1087453001328 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1087453001329 active site 1087453001330 substrate binding site [chemical binding]; other site 1087453001331 metal binding site [ion binding]; metal-binding site 1087453001332 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1087453001333 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1087453001334 metal binding site [ion binding]; metal-binding site 1087453001335 putative dimer interface [polypeptide binding]; other site 1087453001336 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1087453001337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087453001338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087453001339 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1087453001340 pyruvate carboxylase; Reviewed; Region: PRK12999 1087453001341 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087453001342 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087453001343 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1087453001344 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1087453001345 active site 1087453001346 catalytic residues [active] 1087453001347 metal binding site [ion binding]; metal-binding site 1087453001348 homodimer binding site [polypeptide binding]; other site 1087453001349 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087453001350 carboxyltransferase (CT) interaction site; other site 1087453001351 biotinylation site [posttranslational modification]; other site 1087453001352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453001353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453001354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453001355 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1087453001356 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087453001357 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1087453001358 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1087453001359 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087453001360 carboxyltransferase (CT) interaction site; other site 1087453001361 biotinylation site [posttranslational modification]; other site 1087453001362 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1087453001363 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1087453001364 active site residue [active] 1087453001365 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1087453001366 active site residue [active] 1087453001367 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1087453001368 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1087453001369 Maf-like protein; Region: Maf; pfam02545 1087453001370 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1087453001371 active site 1087453001372 dimer interface [polypeptide binding]; other site 1087453001373 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1087453001374 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1087453001375 substrate binding site [chemical binding]; other site 1087453001376 ATP binding site [chemical binding]; other site 1087453001377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1087453001378 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1087453001379 DNA binding site [nucleotide binding] 1087453001380 domain linker motif; other site 1087453001381 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1087453001382 putative ligand binding site [chemical binding]; other site 1087453001383 dimerization interface [polypeptide binding]; other site 1087453001384 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1087453001385 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1087453001386 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087453001387 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087453001388 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1087453001389 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087453001390 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087453001391 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1087453001392 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1087453001393 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1087453001394 ATP-grasp domain; Region: ATP-grasp; pfam02222 1087453001395 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1087453001396 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1087453001397 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1087453001398 putative active site [active] 1087453001399 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1087453001400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001401 dimer interface [polypeptide binding]; other site 1087453001402 conserved gate region; other site 1087453001403 putative PBP binding loops; other site 1087453001404 ABC-ATPase subunit interface; other site 1087453001405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001406 dimer interface [polypeptide binding]; other site 1087453001407 conserved gate region; other site 1087453001408 putative PBP binding loops; other site 1087453001409 ABC-ATPase subunit interface; other site 1087453001410 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1087453001411 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1087453001412 TIGR03089 family protein; Region: TIGR03089 1087453001413 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1087453001414 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1087453001415 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1087453001416 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1087453001417 Probable Catalytic site; other site 1087453001418 metal-binding site 1087453001419 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1087453001420 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1087453001421 active site 1087453001422 Substrate binding site; other site 1087453001423 Mg++ binding site; other site 1087453001424 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087453001425 putative trimer interface [polypeptide binding]; other site 1087453001426 putative CoA binding site [chemical binding]; other site 1087453001427 Transcription factor WhiB; Region: Whib; pfam02467 1087453001428 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1087453001429 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1087453001430 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1087453001431 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1087453001432 active site 1087453001433 substrate binding site [chemical binding]; other site 1087453001434 metal binding site [ion binding]; metal-binding site 1087453001435 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1087453001436 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1087453001437 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1087453001438 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1087453001439 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1087453001440 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1087453001441 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1087453001442 homotetramer interface [polypeptide binding]; other site 1087453001443 ligand binding site [chemical binding]; other site 1087453001444 catalytic site [active] 1087453001445 NAD binding site [chemical binding]; other site 1087453001446 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1087453001447 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1087453001448 TMP-binding site; other site 1087453001449 ATP-binding site [chemical binding]; other site 1087453001450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087453001451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453001452 active site 1087453001453 phosphorylation site [posttranslational modification] 1087453001454 intermolecular recognition site; other site 1087453001455 dimerization interface [polypeptide binding]; other site 1087453001456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087453001457 DNA binding site [nucleotide binding] 1087453001458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087453001459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087453001460 dimerization interface [polypeptide binding]; other site 1087453001461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087453001462 dimer interface [polypeptide binding]; other site 1087453001463 phosphorylation site [posttranslational modification] 1087453001464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453001465 ATP binding site [chemical binding]; other site 1087453001466 Mg2+ binding site [ion binding]; other site 1087453001467 G-X-G motif; other site 1087453001468 lipoprotein LpqB; Provisional; Region: PRK13616 1087453001469 Sporulation and spore germination; Region: Germane; pfam10646 1087453001470 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1087453001471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453001472 active site 1087453001473 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1087453001474 30S subunit binding site; other site 1087453001475 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1087453001476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1087453001477 ATP binding site [chemical binding]; other site 1087453001478 putative Mg++ binding site [ion binding]; other site 1087453001479 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1087453001480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1087453001481 nucleotide binding region [chemical binding]; other site 1087453001482 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1087453001483 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1087453001484 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1087453001485 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1087453001486 FAD binding pocket [chemical binding]; other site 1087453001487 FAD binding motif [chemical binding]; other site 1087453001488 phosphate binding motif [ion binding]; other site 1087453001489 beta-alpha-beta structure motif; other site 1087453001490 NAD binding pocket [chemical binding]; other site 1087453001491 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1087453001492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1087453001493 catalytic loop [active] 1087453001494 iron binding site [ion binding]; other site 1087453001495 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1087453001496 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1087453001497 putative di-iron ligands [ion binding]; other site 1087453001498 Predicted GTPases [General function prediction only]; Region: COG1162 1087453001499 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1087453001500 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1087453001501 GTP/Mg2+ binding site [chemical binding]; other site 1087453001502 G4 box; other site 1087453001503 G5 box; other site 1087453001504 G1 box; other site 1087453001505 Switch I region; other site 1087453001506 G2 box; other site 1087453001507 G3 box; other site 1087453001508 Switch II region; other site 1087453001509 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1087453001510 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1087453001511 hinge; other site 1087453001512 active site 1087453001513 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1087453001514 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1087453001515 putative deacylase active site [active] 1087453001516 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1087453001517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453001518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453001519 DNA binding residues [nucleotide binding] 1087453001520 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1087453001521 Transcription factor WhiB; Region: Whib; pfam02467 1087453001522 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1087453001523 active site 1087453001524 catalytic triad [active] 1087453001525 oxyanion hole [active] 1087453001526 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1087453001527 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1087453001528 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1087453001529 ATP binding site [chemical binding]; other site 1087453001530 Mg++ binding site [ion binding]; other site 1087453001531 motif III; other site 1087453001532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453001533 nucleotide binding region [chemical binding]; other site 1087453001534 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1087453001535 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1087453001536 TIGR02569 family protein; Region: TIGR02569_actnb 1087453001537 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1087453001538 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1087453001539 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1087453001540 Part of AAA domain; Region: AAA_19; pfam13245 1087453001541 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1087453001542 Ion channel; Region: Ion_trans_2; pfam07885 1087453001543 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1087453001544 TrkA-N domain; Region: TrkA_N; pfam02254 1087453001545 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1087453001546 putative NADH binding site [chemical binding]; other site 1087453001547 putative active site [active] 1087453001548 nudix motif; other site 1087453001549 putative metal binding site [ion binding]; other site 1087453001550 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1087453001551 Part of AAA domain; Region: AAA_19; pfam13245 1087453001552 Family description; Region: UvrD_C_2; pfam13538 1087453001553 HRDC domain; Region: HRDC; pfam00570 1087453001554 Protein of unknown function DUF45; Region: DUF45; cl00636 1087453001555 putative hydrolase; Region: TIGR03624 1087453001556 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1087453001557 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1087453001558 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1087453001559 hypothetical protein; Validated; Region: PRK00068 1087453001560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1087453001561 sequence-specific DNA binding site [nucleotide binding]; other site 1087453001562 salt bridge; other site 1087453001563 Abi-like protein; Region: Abi_2; pfam07751 1087453001564 Predicted helicase [General function prediction only]; Region: COG4889 1087453001565 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1087453001566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453001567 ATP binding site [chemical binding]; other site 1087453001568 putative Mg++ binding site [ion binding]; other site 1087453001569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453001570 ATP-binding site [chemical binding]; other site 1087453001571 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1087453001572 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1087453001573 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1087453001574 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1087453001575 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1087453001576 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1087453001577 Predicted membrane protein [Function unknown]; Region: COG2311 1087453001578 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1087453001579 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453001580 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1087453001581 acyl-activating enzyme (AAE) consensus motif; other site 1087453001582 AMP binding site [chemical binding]; other site 1087453001583 active site 1087453001584 CoA binding site [chemical binding]; other site 1087453001585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1087453001586 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1087453001587 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087453001588 putative trimer interface [polypeptide binding]; other site 1087453001589 putative CoA binding site [chemical binding]; other site 1087453001590 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087453001591 putative trimer interface [polypeptide binding]; other site 1087453001592 putative CoA binding site [chemical binding]; other site 1087453001593 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087453001594 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1087453001595 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1087453001596 active site 1087453001597 catalytic residues [active] 1087453001598 metal binding site [ion binding]; metal-binding site 1087453001599 homodimer binding site [polypeptide binding]; other site 1087453001600 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1087453001601 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087453001602 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087453001603 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087453001604 carboxyltransferase (CT) interaction site; other site 1087453001605 biotinylation site [posttranslational modification]; other site 1087453001606 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087453001607 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1087453001608 active site 1087453001609 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1087453001610 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087453001611 active site 1087453001612 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1087453001613 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1087453001614 RF-1 domain; Region: RF-1; pfam00472 1087453001615 topology modulation protein; Provisional; Region: PRK07261 1087453001616 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1087453001617 active site 1087453001618 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1087453001619 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1087453001620 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1087453001621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453001622 Walker A/P-loop; other site 1087453001623 ATP binding site [chemical binding]; other site 1087453001624 Q-loop/lid; other site 1087453001625 ABC transporter signature motif; other site 1087453001626 Walker B; other site 1087453001627 D-loop; other site 1087453001628 H-loop/switch region; other site 1087453001629 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1087453001630 FtsX-like permease family; Region: FtsX; pfam02687 1087453001631 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1087453001632 SmpB-tmRNA interface; other site 1087453001633 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1087453001634 active site clefts [active] 1087453001635 zinc binding site [ion binding]; other site 1087453001636 dimer interface [polypeptide binding]; other site 1087453001637 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1087453001638 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453001639 intersubunit interface [polypeptide binding]; other site 1087453001640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453001641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453001642 ABC-ATPase subunit interface; other site 1087453001643 dimer interface [polypeptide binding]; other site 1087453001644 putative PBP binding regions; other site 1087453001645 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453001646 ABC-ATPase subunit interface; other site 1087453001647 dimer interface [polypeptide binding]; other site 1087453001648 putative PBP binding regions; other site 1087453001649 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1087453001650 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453001651 Walker A/P-loop; other site 1087453001652 ATP binding site [chemical binding]; other site 1087453001653 Q-loop/lid; other site 1087453001654 ABC transporter signature motif; other site 1087453001655 Walker B; other site 1087453001656 D-loop; other site 1087453001657 H-loop/switch region; other site 1087453001658 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1087453001659 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1087453001660 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1087453001661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453001662 ATP binding site [chemical binding]; other site 1087453001663 putative Mg++ binding site [ion binding]; other site 1087453001664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453001665 nucleotide binding region [chemical binding]; other site 1087453001666 ATP-binding site [chemical binding]; other site 1087453001667 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1087453001668 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1087453001669 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1087453001670 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1087453001671 DNA-binding site [nucleotide binding]; DNA binding site 1087453001672 RNA-binding motif; other site 1087453001673 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1087453001674 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1087453001675 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1087453001676 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1087453001677 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087453001678 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087453001679 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1087453001680 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1087453001681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087453001682 catalytic residue [active] 1087453001683 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1087453001684 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1087453001685 dimer interface [polypeptide binding]; other site 1087453001686 active site 1087453001687 citrylCoA binding site [chemical binding]; other site 1087453001688 NADH binding [chemical binding]; other site 1087453001689 cationic pore residues; other site 1087453001690 oxalacetate/citrate binding site [chemical binding]; other site 1087453001691 coenzyme A binding site [chemical binding]; other site 1087453001692 catalytic triad [active] 1087453001693 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1087453001694 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087453001695 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1087453001696 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1087453001697 E-class dimer interface [polypeptide binding]; other site 1087453001698 P-class dimer interface [polypeptide binding]; other site 1087453001699 active site 1087453001700 Cu2+ binding site [ion binding]; other site 1087453001701 Zn2+ binding site [ion binding]; other site 1087453001702 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1087453001703 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1087453001704 active site 1087453001705 catalytic tetrad [active] 1087453001706 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1087453001707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1087453001708 substrate binding site [chemical binding]; other site 1087453001709 oxyanion hole (OAH) forming residues; other site 1087453001710 trimer interface [polypeptide binding]; other site 1087453001711 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1087453001712 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1087453001713 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1087453001714 Na binding site [ion binding]; other site 1087453001715 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1087453001716 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1087453001717 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1087453001718 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1087453001719 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1087453001720 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1087453001721 multidrug efflux protein NorA; Provisional; Region: PRK00187 1087453001722 cation binding site [ion binding]; other site 1087453001723 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1087453001724 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1087453001725 dimer interface [polypeptide binding]; other site 1087453001726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453001727 catalytic residue [active] 1087453001728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1087453001729 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087453001730 catalytic residue [active] 1087453001731 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1087453001732 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1087453001733 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1087453001734 substrate binding pocket [chemical binding]; other site 1087453001735 active site 1087453001736 iron coordination sites [ion binding]; other site 1087453001737 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1087453001738 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1087453001739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453001740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001741 dimer interface [polypeptide binding]; other site 1087453001742 conserved gate region; other site 1087453001743 putative PBP binding loops; other site 1087453001744 ABC-ATPase subunit interface; other site 1087453001745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1087453001746 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1087453001747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453001748 Walker A/P-loop; other site 1087453001749 ATP binding site [chemical binding]; other site 1087453001750 Q-loop/lid; other site 1087453001751 ABC transporter signature motif; other site 1087453001752 Walker B; other site 1087453001753 D-loop; other site 1087453001754 H-loop/switch region; other site 1087453001755 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453001756 Walker A/P-loop; other site 1087453001757 ATP binding site [chemical binding]; other site 1087453001758 Q-loop/lid; other site 1087453001759 ABC transporter signature motif; other site 1087453001760 Walker B; other site 1087453001761 D-loop; other site 1087453001762 H-loop/switch region; other site 1087453001763 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1087453001764 active site 1087453001765 SAM binding site [chemical binding]; other site 1087453001766 homodimer interface [polypeptide binding]; other site 1087453001767 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1087453001768 catalytic residues [active] 1087453001769 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1087453001770 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1087453001771 folate binding site [chemical binding]; other site 1087453001772 NADP+ binding site [chemical binding]; other site 1087453001773 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1087453001774 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1087453001775 dimerization interface [polypeptide binding]; other site 1087453001776 active site 1087453001777 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1087453001778 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087453001779 active site 1087453001780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453001781 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1087453001782 ATP binding site [chemical binding]; other site 1087453001783 putative Mg++ binding site [ion binding]; other site 1087453001784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453001785 nucleotide binding region [chemical binding]; other site 1087453001786 ATP-binding site [chemical binding]; other site 1087453001787 DEAD/H associated; Region: DEAD_assoc; pfam08494 1087453001788 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1087453001789 active site 1087453001790 SUMO-1 interface [polypeptide binding]; other site 1087453001791 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1087453001792 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1087453001793 putative DNA binding site [nucleotide binding]; other site 1087453001794 catalytic residue [active] 1087453001795 putative H2TH interface [polypeptide binding]; other site 1087453001796 putative catalytic residues [active] 1087453001797 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1087453001798 hypothetical protein; Provisional; Region: PRK11770 1087453001799 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1087453001800 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1087453001801 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1087453001802 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1087453001803 active site 1087453001804 dimer interface [polypeptide binding]; other site 1087453001805 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1087453001806 dimer interface [polypeptide binding]; other site 1087453001807 active site 1087453001808 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1087453001809 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1087453001810 tetramerization interface [polypeptide binding]; other site 1087453001811 NAD(P) binding site [chemical binding]; other site 1087453001812 catalytic residues [active] 1087453001813 hypothetical protein; Provisional; Region: PRK07857 1087453001814 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1087453001815 Part of AAA domain; Region: AAA_19; pfam13245 1087453001816 Family description; Region: UvrD_C_2; pfam13538 1087453001817 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1087453001818 Peptidase family M23; Region: Peptidase_M23; pfam01551 1087453001819 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1087453001820 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1087453001821 active site 1087453001822 substrate binding site [chemical binding]; other site 1087453001823 cosubstrate binding site; other site 1087453001824 catalytic site [active] 1087453001825 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1087453001826 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1087453001827 purine monophosphate binding site [chemical binding]; other site 1087453001828 dimer interface [polypeptide binding]; other site 1087453001829 putative catalytic residues [active] 1087453001830 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1087453001831 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1087453001832 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1087453001833 Walker A/P-loop; other site 1087453001834 ATP binding site [chemical binding]; other site 1087453001835 Q-loop/lid; other site 1087453001836 ABC transporter signature motif; other site 1087453001837 Walker B; other site 1087453001838 D-loop; other site 1087453001839 H-loop/switch region; other site 1087453001840 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1087453001841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1087453001842 substrate binding pocket [chemical binding]; other site 1087453001843 membrane-bound complex binding site; other site 1087453001844 hinge residues; other site 1087453001845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1087453001846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001847 dimer interface [polypeptide binding]; other site 1087453001848 conserved gate region; other site 1087453001849 putative PBP binding loops; other site 1087453001850 ABC-ATPase subunit interface; other site 1087453001851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453001852 dimer interface [polypeptide binding]; other site 1087453001853 conserved gate region; other site 1087453001854 putative PBP binding loops; other site 1087453001855 ABC-ATPase subunit interface; other site 1087453001856 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1087453001857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453001858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453001859 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1087453001860 30S ribosomal protein S18; Provisional; Region: PRK13401 1087453001861 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1087453001862 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1087453001863 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1087453001864 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1087453001865 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1087453001866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087453001867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453001868 active site 1087453001869 phosphorylation site [posttranslational modification] 1087453001870 intermolecular recognition site; other site 1087453001871 dimerization interface [polypeptide binding]; other site 1087453001872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087453001873 DNA binding site [nucleotide binding] 1087453001874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087453001875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087453001876 dimerization interface [polypeptide binding]; other site 1087453001877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087453001878 dimer interface [polypeptide binding]; other site 1087453001879 phosphorylation site [posttranslational modification] 1087453001880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453001881 ATP binding site [chemical binding]; other site 1087453001882 Mg2+ binding site [ion binding]; other site 1087453001883 G-X-G motif; other site 1087453001884 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1087453001885 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1087453001886 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1087453001887 protein binding site [polypeptide binding]; other site 1087453001888 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1087453001889 MPT binding site; other site 1087453001890 trimer interface [polypeptide binding]; other site 1087453001891 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1087453001892 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1087453001893 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1087453001894 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1087453001895 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1087453001896 active site 1087453001897 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1087453001898 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1087453001899 dimer interface [polypeptide binding]; other site 1087453001900 putative functional site; other site 1087453001901 putative MPT binding site; other site 1087453001902 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1087453001903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453001904 Coenzyme A binding pocket [chemical binding]; other site 1087453001905 Predicted membrane protein [Function unknown]; Region: COG2259 1087453001906 Predicted integral membrane protein [Function unknown]; Region: COG5660 1087453001907 Putative zinc-finger; Region: zf-HC2; pfam13490 1087453001908 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1087453001909 BCCT family transporter; Region: BCCT; pfam02028 1087453001910 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1087453001911 Predicted methyltransferases [General function prediction only]; Region: COG0313 1087453001912 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1087453001913 putative SAM binding site [chemical binding]; other site 1087453001914 putative homodimer interface [polypeptide binding]; other site 1087453001915 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1087453001916 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1087453001917 active site 1087453001918 HIGH motif; other site 1087453001919 KMSKS motif; other site 1087453001920 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1087453001921 tRNA binding surface [nucleotide binding]; other site 1087453001922 anticodon binding site; other site 1087453001923 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1087453001924 active site 1087453001925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1087453001926 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1087453001927 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1087453001928 G5 domain; Region: G5; pfam07501 1087453001929 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1087453001930 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1087453001931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453001932 S-adenosylmethionine binding site [chemical binding]; other site 1087453001933 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1087453001934 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1087453001935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453001936 ABC transporter; Region: ABC_tran_2; pfam12848 1087453001937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453001938 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1087453001939 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1087453001940 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1087453001941 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1087453001942 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1087453001943 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1087453001944 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1087453001945 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1087453001946 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1087453001947 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1087453001948 G1 box; other site 1087453001949 putative GEF interaction site [polypeptide binding]; other site 1087453001950 GTP/Mg2+ binding site [chemical binding]; other site 1087453001951 Switch I region; other site 1087453001952 G2 box; other site 1087453001953 G3 box; other site 1087453001954 Switch II region; other site 1087453001955 G4 box; other site 1087453001956 G5 box; other site 1087453001957 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1087453001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453001959 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1087453001960 NAD(P) binding site [chemical binding]; other site 1087453001961 active site 1087453001962 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1087453001963 putative active site [active] 1087453001964 catalytic residue [active] 1087453001965 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1087453001966 FMN binding site [chemical binding]; other site 1087453001967 substrate binding site [chemical binding]; other site 1087453001968 putative catalytic residue [active] 1087453001969 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1087453001970 putative active site [active] 1087453001971 catalytic residue [active] 1087453001972 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1087453001973 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1087453001974 5S rRNA interface [nucleotide binding]; other site 1087453001975 CTC domain interface [polypeptide binding]; other site 1087453001976 L16 interface [polypeptide binding]; other site 1087453001977 pullulanase, type I; Region: pulA_typeI; TIGR02104 1087453001978 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1087453001979 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1087453001980 Ca binding site [ion binding]; other site 1087453001981 active site 1087453001982 catalytic site [active] 1087453001983 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1087453001984 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1087453001985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453001986 active site 1087453001987 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1087453001988 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1087453001989 Substrate binding site; other site 1087453001990 Mg++ binding site; other site 1087453001991 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1087453001992 active site 1087453001993 substrate binding site [chemical binding]; other site 1087453001994 CoA binding site [chemical binding]; other site 1087453001995 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1087453001996 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1087453001997 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1087453001998 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1087453001999 gating phenylalanine in ion channel; other site 1087453002000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453002001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453002002 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1087453002003 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1087453002004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453002005 ATP binding site [chemical binding]; other site 1087453002006 putative Mg++ binding site [ion binding]; other site 1087453002007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002008 nucleotide binding region [chemical binding]; other site 1087453002009 ATP-binding site [chemical binding]; other site 1087453002010 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1087453002011 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1087453002012 Spore germination protein; Region: Spore_permease; cl17796 1087453002013 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1087453002014 homodimer interface [polypeptide binding]; other site 1087453002015 metal binding site [ion binding]; metal-binding site 1087453002016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1087453002017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1087453002018 enolase; Provisional; Region: eno; PRK00077 1087453002019 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1087453002020 dimer interface [polypeptide binding]; other site 1087453002021 metal binding site [ion binding]; metal-binding site 1087453002022 substrate binding pocket [chemical binding]; other site 1087453002023 Septum formation initiator; Region: DivIC; pfam04977 1087453002024 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1087453002025 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1087453002026 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1087453002027 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1087453002028 Helix-turn-helix domain; Region: HTH_18; pfam12833 1087453002029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1087453002030 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1087453002031 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1087453002032 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1087453002033 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1087453002034 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1087453002035 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1087453002036 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1087453002037 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1087453002038 catalytic residue [active] 1087453002039 putative FPP diphosphate binding site; other site 1087453002040 putative FPP binding hydrophobic cleft; other site 1087453002041 dimer interface [polypeptide binding]; other site 1087453002042 putative IPP diphosphate binding site; other site 1087453002043 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1087453002044 pantothenate kinase; Provisional; Region: PRK05439 1087453002045 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1087453002046 ATP-binding site [chemical binding]; other site 1087453002047 CoA-binding site [chemical binding]; other site 1087453002048 Mg2+-binding site [ion binding]; other site 1087453002049 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1087453002050 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1087453002051 dimer interface [polypeptide binding]; other site 1087453002052 active site 1087453002053 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1087453002054 folate binding site [chemical binding]; other site 1087453002055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453002056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453002057 putative substrate translocation pore; other site 1087453002058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453002059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453002060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1087453002061 dimerization interface [polypeptide binding]; other site 1087453002062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1087453002063 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1087453002064 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1087453002065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453002066 Coenzyme A binding pocket [chemical binding]; other site 1087453002067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453002068 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1087453002069 putative substrate translocation pore; other site 1087453002070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453002071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453002072 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1087453002073 Class II fumarases; Region: Fumarase_classII; cd01362 1087453002074 active site 1087453002075 tetramer interface [polypeptide binding]; other site 1087453002076 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1087453002077 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1087453002078 putative active site [active] 1087453002079 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1087453002080 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1087453002081 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1087453002082 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1087453002083 generic binding surface II; other site 1087453002084 generic binding surface I; other site 1087453002085 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1087453002086 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1087453002087 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087453002088 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1087453002089 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1087453002090 GTP-binding protein YchF; Reviewed; Region: PRK09601 1087453002091 YchF GTPase; Region: YchF; cd01900 1087453002092 G1 box; other site 1087453002093 GTP/Mg2+ binding site [chemical binding]; other site 1087453002094 Switch I region; other site 1087453002095 G2 box; other site 1087453002096 Switch II region; other site 1087453002097 G3 box; other site 1087453002098 G4 box; other site 1087453002099 G5 box; other site 1087453002100 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1087453002101 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1087453002102 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1087453002103 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1087453002104 PhnA protein; Region: PhnA; pfam03831 1087453002105 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1087453002106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087453002107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453002108 Walker A/P-loop; other site 1087453002109 ATP binding site [chemical binding]; other site 1087453002110 Q-loop/lid; other site 1087453002111 ABC transporter signature motif; other site 1087453002112 Walker B; other site 1087453002113 D-loop; other site 1087453002114 H-loop/switch region; other site 1087453002115 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1087453002116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087453002117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453002118 Walker A/P-loop; other site 1087453002119 ATP binding site [chemical binding]; other site 1087453002120 Q-loop/lid; other site 1087453002121 ABC transporter signature motif; other site 1087453002122 Walker B; other site 1087453002123 D-loop; other site 1087453002124 H-loop/switch region; other site 1087453002125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1087453002126 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1087453002127 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1087453002128 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1087453002129 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1087453002130 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1087453002131 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1087453002132 Walker A/P-loop; other site 1087453002133 ATP binding site [chemical binding]; other site 1087453002134 Q-loop/lid; other site 1087453002135 ABC transporter signature motif; other site 1087453002136 Walker B; other site 1087453002137 D-loop; other site 1087453002138 H-loop/switch region; other site 1087453002139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453002140 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1087453002141 Walker A/P-loop; other site 1087453002142 ATP binding site [chemical binding]; other site 1087453002143 Q-loop/lid; other site 1087453002144 ABC transporter signature motif; other site 1087453002145 Walker B; other site 1087453002146 D-loop; other site 1087453002147 H-loop/switch region; other site 1087453002148 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1087453002149 hypothetical protein; Provisional; Region: PRK06547 1087453002150 Predicted kinase [General function prediction only]; Region: COG0645 1087453002151 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1087453002152 nudix motif; other site 1087453002153 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1087453002154 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1087453002155 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453002156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453002157 dimer interface [polypeptide binding]; other site 1087453002158 conserved gate region; other site 1087453002159 ABC-ATPase subunit interface; other site 1087453002160 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1087453002161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453002162 dimer interface [polypeptide binding]; other site 1087453002163 conserved gate region; other site 1087453002164 putative PBP binding loops; other site 1087453002165 ABC-ATPase subunit interface; other site 1087453002166 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1087453002167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453002168 Walker A/P-loop; other site 1087453002169 ATP binding site [chemical binding]; other site 1087453002170 Q-loop/lid; other site 1087453002171 ABC transporter signature motif; other site 1087453002172 Walker B; other site 1087453002173 D-loop; other site 1087453002174 H-loop/switch region; other site 1087453002175 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453002176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453002177 Walker A/P-loop; other site 1087453002178 ATP binding site [chemical binding]; other site 1087453002179 Q-loop/lid; other site 1087453002180 ABC transporter signature motif; other site 1087453002181 Walker B; other site 1087453002182 D-loop; other site 1087453002183 H-loop/switch region; other site 1087453002184 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453002185 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1087453002186 cleavage site 1087453002187 active site 1087453002188 substrate binding sites [chemical binding]; other site 1087453002189 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1087453002190 ArsC family; Region: ArsC; pfam03960 1087453002191 catalytic residues [active] 1087453002192 Protein of unknown function (DUF402); Region: DUF402; cl00979 1087453002193 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1087453002194 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1087453002195 G1 box; other site 1087453002196 GTP/Mg2+ binding site [chemical binding]; other site 1087453002197 G2 box; other site 1087453002198 Switch I region; other site 1087453002199 G3 box; other site 1087453002200 Switch II region; other site 1087453002201 G4 box; other site 1087453002202 G5 box; other site 1087453002203 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1087453002204 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1087453002205 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1087453002206 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1087453002207 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1087453002208 Ferredoxin [Energy production and conversion]; Region: COG1146 1087453002209 4Fe-4S binding domain; Region: Fer4; pfam00037 1087453002210 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1087453002211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087453002212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453002213 homodimer interface [polypeptide binding]; other site 1087453002214 catalytic residue [active] 1087453002215 Predicted membrane protein [Function unknown]; Region: COG2246 1087453002216 GtrA-like protein; Region: GtrA; pfam04138 1087453002217 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1087453002218 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087453002219 active site 1087453002220 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087453002221 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1087453002222 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1087453002223 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1087453002224 putative trimer interface [polypeptide binding]; other site 1087453002225 putative CoA binding site [chemical binding]; other site 1087453002226 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087453002227 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1087453002228 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1087453002229 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087453002230 putative trimer interface [polypeptide binding]; other site 1087453002231 putative CoA binding site [chemical binding]; other site 1087453002232 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1087453002233 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1087453002234 metal binding site [ion binding]; metal-binding site 1087453002235 putative dimer interface [polypeptide binding]; other site 1087453002236 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1087453002237 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1087453002238 dihydropteroate synthase; Region: DHPS; TIGR01496 1087453002239 substrate binding pocket [chemical binding]; other site 1087453002240 dimer interface [polypeptide binding]; other site 1087453002241 inhibitor binding site; inhibition site 1087453002242 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1087453002243 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1087453002244 Ligand binding site; other site 1087453002245 Putative Catalytic site; other site 1087453002246 DXD motif; other site 1087453002247 DivIVA domain; Region: DivI1A_domain; TIGR03544 1087453002248 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1087453002249 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1087453002250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002251 S-adenosylmethionine binding site [chemical binding]; other site 1087453002252 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1087453002253 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1087453002254 active site 1087453002255 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1087453002256 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1087453002257 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1087453002258 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087453002259 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1087453002260 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1087453002261 ligand binding site; other site 1087453002262 oligomer interface; other site 1087453002263 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1087453002264 dimer interface [polypeptide binding]; other site 1087453002265 N-terminal domain interface [polypeptide binding]; other site 1087453002266 sulfate 1 binding site; other site 1087453002267 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1087453002268 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1087453002269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453002270 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453002271 DNA binding residues [nucleotide binding] 1087453002272 sec-independent translocase; Provisional; Region: tatB; PRK00182 1087453002273 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1087453002274 Domain of unknown function DUF59; Region: DUF59; pfam01883 1087453002275 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1087453002276 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1087453002277 Predicted membrane protein [Function unknown]; Region: COG4420 1087453002278 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1087453002279 MgtE intracellular N domain; Region: MgtE_N; smart00924 1087453002280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1087453002281 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1087453002282 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1087453002283 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1087453002284 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1087453002285 TPP-binding site [chemical binding]; other site 1087453002286 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1087453002287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1087453002288 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087453002289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453002290 Walker A/P-loop; other site 1087453002291 ATP binding site [chemical binding]; other site 1087453002292 Q-loop/lid; other site 1087453002293 ABC transporter signature motif; other site 1087453002294 Walker B; other site 1087453002295 D-loop; other site 1087453002296 H-loop/switch region; other site 1087453002297 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1087453002298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087453002299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453002300 Walker A/P-loop; other site 1087453002301 ATP binding site [chemical binding]; other site 1087453002302 Q-loop/lid; other site 1087453002303 ABC transporter signature motif; other site 1087453002304 Walker B; other site 1087453002305 D-loop; other site 1087453002306 H-loop/switch region; other site 1087453002307 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1087453002308 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1087453002309 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1087453002310 shikimate binding site; other site 1087453002311 NAD(P) binding site [chemical binding]; other site 1087453002312 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1087453002313 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1087453002314 substrate binding pocket [chemical binding]; other site 1087453002315 catalytic triad [active] 1087453002316 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1087453002317 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1087453002318 active site 1087453002319 catalytic residues [active] 1087453002320 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1087453002321 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1087453002322 Na binding site [ion binding]; other site 1087453002323 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1087453002324 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1087453002325 nucleotide binding site/active site [active] 1087453002326 HIT family signature motif; other site 1087453002327 catalytic residue [active] 1087453002328 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1087453002329 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1087453002330 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1087453002331 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1087453002332 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1087453002333 ATP binding site [chemical binding]; other site 1087453002334 Mg++ binding site [ion binding]; other site 1087453002335 motif III; other site 1087453002336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002337 nucleotide binding region [chemical binding]; other site 1087453002338 ATP-binding site [chemical binding]; other site 1087453002339 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1087453002340 putative RNA binding site [nucleotide binding]; other site 1087453002341 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1087453002342 dimer interface [polypeptide binding]; other site 1087453002343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087453002344 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1087453002345 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1087453002346 Na binding site [ion binding]; other site 1087453002347 SNF2 Helicase protein; Region: DUF3670; pfam12419 1087453002348 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1087453002349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453002350 ATP binding site [chemical binding]; other site 1087453002351 putative Mg++ binding site [ion binding]; other site 1087453002352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002353 nucleotide binding region [chemical binding]; other site 1087453002354 ATP-binding site [chemical binding]; other site 1087453002355 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1087453002356 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1087453002357 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1087453002358 active site 1087453002359 metal binding site [ion binding]; metal-binding site 1087453002360 DNA binding site [nucleotide binding] 1087453002361 AAA domain; Region: AAA_23; pfam13476 1087453002362 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1087453002363 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1087453002364 MarR family; Region: MarR_2; pfam12802 1087453002365 PspC domain; Region: PspC; pfam04024 1087453002366 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1087453002367 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1087453002368 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1087453002369 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1087453002370 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1087453002371 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1087453002372 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1087453002373 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1087453002374 Cysteine-rich domain; Region: CCG; pfam02754 1087453002375 Cysteine-rich domain; Region: CCG; pfam02754 1087453002376 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1087453002377 L-lactate permease; Region: Lactate_perm; cl00701 1087453002378 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1087453002379 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1087453002380 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1087453002381 active site 1087453002382 HIGH motif; other site 1087453002383 KMSK motif region; other site 1087453002384 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1087453002385 tRNA binding surface [nucleotide binding]; other site 1087453002386 anticodon binding site; other site 1087453002387 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1087453002388 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1087453002389 active site 1087453002390 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087453002391 substrate binding site [chemical binding]; other site 1087453002392 catalytic residues [active] 1087453002393 dimer interface [polypeptide binding]; other site 1087453002394 homoserine dehydrogenase; Provisional; Region: PRK06349 1087453002395 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1087453002396 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1087453002397 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1087453002398 homoserine kinase; Provisional; Region: PRK01212 1087453002399 Predicted transcriptional regulator [Transcription]; Region: COG2345 1087453002400 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 1087453002401 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1087453002402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453002403 acyl-activating enzyme (AAE) consensus motif; other site 1087453002404 AMP binding site [chemical binding]; other site 1087453002405 active site 1087453002406 CoA binding site [chemical binding]; other site 1087453002407 transcription termination factor Rho; Provisional; Region: PRK12678 1087453002408 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1087453002409 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1087453002410 RNA binding site [nucleotide binding]; other site 1087453002411 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1087453002412 multimer interface [polypeptide binding]; other site 1087453002413 Walker A motif; other site 1087453002414 ATP binding site [chemical binding]; other site 1087453002415 Walker B motif; other site 1087453002416 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1087453002417 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1087453002418 RF-1 domain; Region: RF-1; pfam00472 1087453002419 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1087453002420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002421 S-adenosylmethionine binding site [chemical binding]; other site 1087453002422 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1087453002423 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1087453002424 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1087453002425 Mg++ binding site [ion binding]; other site 1087453002426 putative catalytic motif [active] 1087453002427 substrate binding site [chemical binding]; other site 1087453002428 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1087453002429 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1087453002430 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1087453002431 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1087453002432 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1087453002433 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1087453002434 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1087453002435 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1087453002436 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1087453002437 beta subunit interaction interface [polypeptide binding]; other site 1087453002438 Walker A motif; other site 1087453002439 ATP binding site [chemical binding]; other site 1087453002440 Walker B motif; other site 1087453002441 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1087453002442 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1087453002443 core domain interface [polypeptide binding]; other site 1087453002444 delta subunit interface [polypeptide binding]; other site 1087453002445 epsilon subunit interface [polypeptide binding]; other site 1087453002446 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1087453002447 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1087453002448 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1087453002449 alpha subunit interaction interface [polypeptide binding]; other site 1087453002450 Walker A motif; other site 1087453002451 ATP binding site [chemical binding]; other site 1087453002452 Walker B motif; other site 1087453002453 inhibitor binding site; inhibition site 1087453002454 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1087453002455 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1087453002456 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1087453002457 gamma subunit interface [polypeptide binding]; other site 1087453002458 epsilon subunit interface [polypeptide binding]; other site 1087453002459 LBP interface [polypeptide binding]; other site 1087453002460 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1087453002461 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1087453002462 hypothetical protein; Provisional; Region: PRK03298 1087453002463 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1087453002464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087453002465 dimer interface [polypeptide binding]; other site 1087453002466 substrate binding site [chemical binding]; other site 1087453002467 metal binding site [ion binding]; metal-binding site 1087453002468 Domain of unknown function DUF77; Region: DUF77; pfam01910 1087453002469 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1087453002470 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1087453002471 glycogen branching enzyme; Provisional; Region: PRK05402 1087453002472 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1087453002473 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1087453002474 active site 1087453002475 catalytic site [active] 1087453002476 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1087453002477 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1087453002478 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1087453002479 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1087453002480 active site 1087453002481 catalytic site [active] 1087453002482 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453002483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453002484 Walker A/P-loop; other site 1087453002485 ATP binding site [chemical binding]; other site 1087453002486 ABC transporter signature motif; other site 1087453002487 Walker B; other site 1087453002488 D-loop; other site 1087453002489 H-loop/switch region; other site 1087453002490 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1087453002491 Ligand binding site [chemical binding]; other site 1087453002492 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1087453002493 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1087453002494 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1087453002495 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1087453002496 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1087453002497 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1087453002498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087453002499 catalytic residue [active] 1087453002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002501 S-adenosylmethionine binding site [chemical binding]; other site 1087453002502 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1087453002503 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1087453002504 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1087453002505 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1087453002506 active site 1087453002507 catalytic site [active] 1087453002508 substrate binding site [chemical binding]; other site 1087453002509 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1087453002510 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1087453002511 nucleotide binding pocket [chemical binding]; other site 1087453002512 K-X-D-G motif; other site 1087453002513 catalytic site [active] 1087453002514 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1087453002515 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1087453002516 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1087453002517 Dimer interface [polypeptide binding]; other site 1087453002518 BRCT sequence motif; other site 1087453002519 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1087453002520 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1087453002521 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1087453002522 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1087453002523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1087453002524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453002525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453002526 putative substrate translocation pore; other site 1087453002527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453002528 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453002529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453002530 ABC-ATPase subunit interface; other site 1087453002531 dimer interface [polypeptide binding]; other site 1087453002532 putative PBP binding regions; other site 1087453002533 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453002534 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1087453002535 Walker A/P-loop; other site 1087453002536 ATP binding site [chemical binding]; other site 1087453002537 Q-loop/lid; other site 1087453002538 ABC transporter signature motif; other site 1087453002539 Walker B; other site 1087453002540 D-loop; other site 1087453002541 H-loop/switch region; other site 1087453002542 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1087453002543 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1087453002544 putative ligand binding residues [chemical binding]; other site 1087453002545 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1087453002546 phosphofructokinase; Region: PFK_mixed; TIGR02483 1087453002547 active site 1087453002548 ADP/pyrophosphate binding site [chemical binding]; other site 1087453002549 dimerization interface [polypeptide binding]; other site 1087453002550 allosteric effector site; other site 1087453002551 fructose-1,6-bisphosphate binding site; other site 1087453002552 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1087453002553 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1087453002554 GatB domain; Region: GatB_Yqey; smart00845 1087453002555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1087453002556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1087453002557 active site 1087453002558 catalytic tetrad [active] 1087453002559 Lysine efflux permease [General function prediction only]; Region: COG1279 1087453002560 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1087453002561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1087453002562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1087453002563 dimerization interface [polypeptide binding]; other site 1087453002564 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1087453002565 Predicted membrane protein [Function unknown]; Region: COG2259 1087453002566 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1087453002567 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1087453002568 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1087453002569 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1087453002570 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1087453002571 putative valine binding site [chemical binding]; other site 1087453002572 dimer interface [polypeptide binding]; other site 1087453002573 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1087453002574 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1087453002575 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1087453002576 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1087453002577 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1087453002578 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1087453002579 Protein of unknown function DUF262; Region: DUF262; pfam03235 1087453002580 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1087453002581 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1087453002582 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1087453002583 ligand binding site [chemical binding]; other site 1087453002584 NAD binding site [chemical binding]; other site 1087453002585 dimerization interface [polypeptide binding]; other site 1087453002586 catalytic site [active] 1087453002587 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1087453002588 putative L-serine binding site [chemical binding]; other site 1087453002589 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1087453002590 tartrate dehydrogenase; Region: TTC; TIGR02089 1087453002591 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1087453002592 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1087453002593 ligand binding site [chemical binding]; other site 1087453002594 flexible hinge region; other site 1087453002595 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1087453002596 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087453002597 metal binding triad; other site 1087453002598 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1087453002599 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1087453002600 active site 1087453002601 catalytic site [active] 1087453002602 substrate binding site [chemical binding]; other site 1087453002603 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1087453002604 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1087453002605 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1087453002606 isochorismate synthase DhbC; Validated; Region: PRK06923 1087453002607 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1087453002608 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1087453002609 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453002610 HIGH motif; other site 1087453002611 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1087453002612 active site 1087453002613 KMSKS motif; other site 1087453002614 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1087453002615 Cutinase; Region: Cutinase; pfam01083 1087453002616 biotin synthase; Region: bioB; TIGR00433 1087453002617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453002618 FeS/SAM binding site; other site 1087453002619 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1087453002620 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1087453002621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087453002622 Zn2+ binding site [ion binding]; other site 1087453002623 Mg2+ binding site [ion binding]; other site 1087453002624 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1087453002625 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1087453002626 Bacterial transcriptional regulator; Region: IclR; pfam01614 1087453002627 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1087453002628 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1087453002629 substrate binding site [chemical binding]; other site 1087453002630 ligand binding site [chemical binding]; other site 1087453002631 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1087453002632 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1087453002633 substrate binding site [chemical binding]; other site 1087453002634 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1087453002635 active site 1087453002636 Ap6A binding site [chemical binding]; other site 1087453002637 nudix motif; other site 1087453002638 metal binding site [ion binding]; metal-binding site 1087453002639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453002640 catalytic core [active] 1087453002641 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1087453002642 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1087453002643 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1087453002644 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1087453002645 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1087453002646 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087453002647 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1087453002648 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1087453002649 thiamine monophosphate kinase; Provisional; Region: PRK05731 1087453002650 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1087453002651 ATP binding site [chemical binding]; other site 1087453002652 dimerization interface [polypeptide binding]; other site 1087453002653 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1087453002654 ligand binding site [chemical binding]; other site 1087453002655 active site 1087453002656 UGI interface [polypeptide binding]; other site 1087453002657 catalytic site [active] 1087453002658 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1087453002659 DAK2 domain; Region: Dak2; pfam02734 1087453002660 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1087453002661 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1087453002662 generic binding surface II; other site 1087453002663 ssDNA binding site; other site 1087453002664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453002665 ATP binding site [chemical binding]; other site 1087453002666 putative Mg++ binding site [ion binding]; other site 1087453002667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002668 nucleotide binding region [chemical binding]; other site 1087453002669 ATP-binding site [chemical binding]; other site 1087453002670 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1087453002671 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087453002672 carboxyltransferase (CT) interaction site; other site 1087453002673 biotinylation site [posttranslational modification]; other site 1087453002674 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1087453002675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002676 S-adenosylmethionine binding site [chemical binding]; other site 1087453002677 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1087453002678 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1087453002679 active site 1087453002680 (T/H)XGH motif; other site 1087453002681 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1087453002682 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1087453002683 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1087453002684 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1087453002685 Walker A/P-loop; other site 1087453002686 ATP binding site [chemical binding]; other site 1087453002687 Q-loop/lid; other site 1087453002688 ABC transporter signature motif; other site 1087453002689 Walker B; other site 1087453002690 D-loop; other site 1087453002691 H-loop/switch region; other site 1087453002692 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1087453002693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453002694 dimer interface [polypeptide binding]; other site 1087453002695 conserved gate region; other site 1087453002696 putative PBP binding loops; other site 1087453002697 ABC-ATPase subunit interface; other site 1087453002698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1087453002699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1087453002700 substrate binding pocket [chemical binding]; other site 1087453002701 membrane-bound complex binding site; other site 1087453002702 hinge residues; other site 1087453002703 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1087453002704 DNA polymerase I; Provisional; Region: PRK05755 1087453002705 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1087453002706 active site 1087453002707 metal binding site 1 [ion binding]; metal-binding site 1087453002708 putative 5' ssDNA interaction site; other site 1087453002709 metal binding site 3; metal-binding site 1087453002710 metal binding site 2 [ion binding]; metal-binding site 1087453002711 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1087453002712 putative DNA binding site [nucleotide binding]; other site 1087453002713 putative metal binding site [ion binding]; other site 1087453002714 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1087453002715 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1087453002716 active site 1087453002717 DNA binding site [nucleotide binding] 1087453002718 catalytic site [active] 1087453002719 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1087453002720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002721 S-adenosylmethionine binding site [chemical binding]; other site 1087453002722 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1087453002723 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1087453002724 RNA binding site [nucleotide binding]; other site 1087453002725 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1087453002726 RNA binding site [nucleotide binding]; other site 1087453002727 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1087453002728 RNA binding site [nucleotide binding]; other site 1087453002729 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1087453002730 RNA binding site [nucleotide binding]; other site 1087453002731 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1087453002732 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1087453002733 active site turn [active] 1087453002734 phosphorylation site [posttranslational modification] 1087453002735 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1087453002736 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1087453002737 HPr interaction site; other site 1087453002738 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1087453002739 active site 1087453002740 phosphorylation site [posttranslational modification] 1087453002741 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1087453002742 ATP-binding [chemical binding]; other site 1087453002743 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1087453002744 CoA-binding site [chemical binding]; other site 1087453002745 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1087453002746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453002747 FeS/SAM binding site; other site 1087453002748 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1087453002749 excinuclease ABC subunit B; Provisional; Region: PRK05298 1087453002750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453002751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002752 nucleotide binding region [chemical binding]; other site 1087453002753 ATP-binding site [chemical binding]; other site 1087453002754 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1087453002755 UvrB/uvrC motif; Region: UVR; pfam02151 1087453002756 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087453002757 Ligand Binding Site [chemical binding]; other site 1087453002758 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1087453002759 Part of AAA domain; Region: AAA_19; pfam13245 1087453002760 Family description; Region: UvrD_C_2; pfam13538 1087453002761 Predicted membrane protein [Function unknown]; Region: COG2259 1087453002762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1087453002763 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1087453002764 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1087453002765 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1087453002766 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1087453002767 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1087453002768 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1087453002769 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1087453002770 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1087453002771 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1087453002772 23S rRNA binding site [nucleotide binding]; other site 1087453002773 L21 binding site [polypeptide binding]; other site 1087453002774 L13 binding site [polypeptide binding]; other site 1087453002775 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087453002776 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1087453002777 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087453002778 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1087453002779 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1087453002780 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1087453002781 dimer interface [polypeptide binding]; other site 1087453002782 motif 1; other site 1087453002783 active site 1087453002784 motif 2; other site 1087453002785 motif 3; other site 1087453002786 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1087453002787 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1087453002788 putative tRNA-binding site [nucleotide binding]; other site 1087453002789 B3/4 domain; Region: B3_4; pfam03483 1087453002790 tRNA synthetase B5 domain; Region: B5; smart00874 1087453002791 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1087453002792 dimer interface [polypeptide binding]; other site 1087453002793 motif 1; other site 1087453002794 motif 3; other site 1087453002795 motif 2; other site 1087453002796 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1087453002797 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1087453002798 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1087453002799 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1087453002800 feedback inhibition sensing region; other site 1087453002801 homohexameric interface [polypeptide binding]; other site 1087453002802 nucleotide binding site [chemical binding]; other site 1087453002803 N-acetyl-L-glutamate binding site [chemical binding]; other site 1087453002804 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1087453002805 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1087453002806 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1087453002807 arginine repressor; Provisional; Region: PRK03341 1087453002808 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1087453002809 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1087453002810 argininosuccinate synthase; Provisional; Region: PRK13820 1087453002811 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1087453002812 ANP binding site [chemical binding]; other site 1087453002813 Substrate Binding Site II [chemical binding]; other site 1087453002814 Substrate Binding Site I [chemical binding]; other site 1087453002815 argininosuccinate lyase; Provisional; Region: PRK00855 1087453002816 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1087453002817 active sites [active] 1087453002818 tetramer interface [polypeptide binding]; other site 1087453002819 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1087453002820 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1087453002821 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1087453002822 active site 1087453002823 HIGH motif; other site 1087453002824 dimer interface [polypeptide binding]; other site 1087453002825 KMSKS motif; other site 1087453002826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087453002827 RNA binding surface [nucleotide binding]; other site 1087453002828 transcription termination factor Rho; Provisional; Region: PRK12678 1087453002829 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1087453002830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453002831 active site 1087453002832 motif I; other site 1087453002833 motif II; other site 1087453002834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453002835 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1087453002836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087453002837 RNA binding surface [nucleotide binding]; other site 1087453002838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002839 S-adenosylmethionine binding site [chemical binding]; other site 1087453002840 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1087453002841 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1087453002842 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1087453002843 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1087453002844 Walker A/P-loop; other site 1087453002845 ATP binding site [chemical binding]; other site 1087453002846 Q-loop/lid; other site 1087453002847 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1087453002848 ABC transporter signature motif; other site 1087453002849 Walker B; other site 1087453002850 D-loop; other site 1087453002851 H-loop/switch region; other site 1087453002852 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1087453002853 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1087453002854 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1087453002855 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1087453002856 dimer interface [polypeptide binding]; other site 1087453002857 ADP-ribose binding site [chemical binding]; other site 1087453002858 active site 1087453002859 nudix motif; other site 1087453002860 metal binding site [ion binding]; metal-binding site 1087453002861 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1087453002862 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1087453002863 active site 1087453002864 Int/Topo IB signature motif; other site 1087453002865 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1087453002866 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1087453002867 P-loop; other site 1087453002868 Magnesium ion binding site [ion binding]; other site 1087453002869 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1087453002870 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1087453002871 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1087453002872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453002873 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1087453002874 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1087453002875 inhibitor-cofactor binding pocket; inhibition site 1087453002876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453002877 catalytic residue [active] 1087453002878 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1087453002879 AAA domain; Region: AAA_26; pfam13500 1087453002880 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1087453002881 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1087453002882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087453002883 RNA binding surface [nucleotide binding]; other site 1087453002884 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1087453002885 active site 1087453002886 cytidylate kinase; Provisional; Region: cmk; PRK00023 1087453002887 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1087453002888 CMP-binding site; other site 1087453002889 The sites determining sugar specificity; other site 1087453002890 GTP-binding protein Der; Reviewed; Region: PRK03003 1087453002891 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1087453002892 G1 box; other site 1087453002893 GTP/Mg2+ binding site [chemical binding]; other site 1087453002894 Switch I region; other site 1087453002895 G2 box; other site 1087453002896 Switch II region; other site 1087453002897 G3 box; other site 1087453002898 G4 box; other site 1087453002899 G5 box; other site 1087453002900 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1087453002901 G1 box; other site 1087453002902 GTP/Mg2+ binding site [chemical binding]; other site 1087453002903 Switch I region; other site 1087453002904 G2 box; other site 1087453002905 G3 box; other site 1087453002906 Switch II region; other site 1087453002907 G4 box; other site 1087453002908 G5 box; other site 1087453002909 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1087453002910 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1087453002911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002912 S-adenosylmethionine binding site [chemical binding]; other site 1087453002913 Predicted esterase [General function prediction only]; Region: COG0627 1087453002914 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1087453002915 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1087453002916 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453002917 intersubunit interface [polypeptide binding]; other site 1087453002918 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453002919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453002920 dimer interface [polypeptide binding]; other site 1087453002921 ABC-ATPase subunit interface; other site 1087453002922 putative PBP binding regions; other site 1087453002923 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453002924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453002925 ABC-ATPase subunit interface; other site 1087453002926 dimer interface [polypeptide binding]; other site 1087453002927 putative PBP binding regions; other site 1087453002928 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453002929 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453002930 Walker A/P-loop; other site 1087453002931 ATP binding site [chemical binding]; other site 1087453002932 Q-loop/lid; other site 1087453002933 ABC transporter signature motif; other site 1087453002934 Walker B; other site 1087453002935 D-loop; other site 1087453002936 H-loop/switch region; other site 1087453002937 IucA / IucC family; Region: IucA_IucC; pfam04183 1087453002938 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1087453002939 IucA / IucC family; Region: IucA_IucC; pfam04183 1087453002940 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1087453002941 H+ Antiporter protein; Region: 2A0121; TIGR00900 1087453002942 hypothetical protein; Provisional; Region: PRK01842 1087453002943 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1087453002944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087453002945 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1087453002946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1087453002947 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1087453002948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002949 nucleotide binding region [chemical binding]; other site 1087453002950 ATP-binding site [chemical binding]; other site 1087453002951 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1087453002952 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1087453002953 phosphopeptide binding site; other site 1087453002954 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1087453002955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1087453002956 DNA binding residues [nucleotide binding] 1087453002957 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1087453002958 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1087453002959 DNA binding residues [nucleotide binding] 1087453002960 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1087453002961 putative dimer interface [polypeptide binding]; other site 1087453002962 Domain of unknown function DUF21; Region: DUF21; pfam01595 1087453002963 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1087453002964 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1087453002965 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1087453002966 Domain of unknown function DUF21; Region: DUF21; pfam01595 1087453002967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1087453002968 Transporter associated domain; Region: CorC_HlyC; smart01091 1087453002969 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1087453002970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1087453002971 ATP binding site [chemical binding]; other site 1087453002972 putative Mg++ binding site [ion binding]; other site 1087453002973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453002974 nucleotide binding region [chemical binding]; other site 1087453002975 ATP-binding site [chemical binding]; other site 1087453002976 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1087453002977 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1087453002978 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1087453002979 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1087453002980 CoenzymeA binding site [chemical binding]; other site 1087453002981 subunit interaction site [polypeptide binding]; other site 1087453002982 PHB binding site; other site 1087453002983 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1087453002984 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1087453002985 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1087453002986 oligomer interface [polypeptide binding]; other site 1087453002987 metal binding site [ion binding]; metal-binding site 1087453002988 metal binding site [ion binding]; metal-binding site 1087453002989 putative Cl binding site [ion binding]; other site 1087453002990 basic sphincter; other site 1087453002991 hydrophobic gate; other site 1087453002992 periplasmic entrance; other site 1087453002993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453002994 S-adenosylmethionine binding site [chemical binding]; other site 1087453002995 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1087453002996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087453002997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087453002998 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1087453002999 metabolite-proton symporter; Region: 2A0106; TIGR00883 1087453003000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453003001 putative substrate translocation pore; other site 1087453003002 YceI-like domain; Region: YceI; pfam04264 1087453003003 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1087453003004 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1087453003005 Ligand binding site; other site 1087453003006 Putative Catalytic site; other site 1087453003007 DXD motif; other site 1087453003008 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1087453003009 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1087453003010 putative active site [active] 1087453003011 catalytic triad [active] 1087453003012 putative dimer interface [polypeptide binding]; other site 1087453003013 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1087453003014 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1087453003015 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1087453003016 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1087453003017 precorrin-3B synthase; Region: CobG; TIGR02435 1087453003018 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1087453003019 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1087453003020 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1087453003021 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1087453003022 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1087453003023 active site 1087453003024 SAM binding site [chemical binding]; other site 1087453003025 homodimer interface [polypeptide binding]; other site 1087453003026 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1087453003027 active site 1087453003028 SAM binding site [chemical binding]; other site 1087453003029 homodimer interface [polypeptide binding]; other site 1087453003030 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1087453003031 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1087453003032 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1087453003033 active site 1087453003034 SAM binding site [chemical binding]; other site 1087453003035 homodimer interface [polypeptide binding]; other site 1087453003036 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1087453003037 active site 1087453003038 putative homodimer interface [polypeptide binding]; other site 1087453003039 SAM binding site [chemical binding]; other site 1087453003040 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1087453003041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453003042 S-adenosylmethionine binding site [chemical binding]; other site 1087453003043 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1087453003044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453003045 NAD(P) binding site [chemical binding]; other site 1087453003046 active site 1087453003047 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1087453003048 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1087453003049 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1087453003050 active site 1087453003051 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1087453003052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453003053 ATP binding site [chemical binding]; other site 1087453003054 putative Mg++ binding site [ion binding]; other site 1087453003055 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1087453003056 nucleotide binding region [chemical binding]; other site 1087453003057 ATP-binding site [chemical binding]; other site 1087453003058 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1087453003059 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1087453003060 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1087453003061 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1087453003062 Predicted transcriptional regulator [Transcription]; Region: COG2378 1087453003063 WYL domain; Region: WYL; pfam13280 1087453003064 Predicted transcriptional regulator [Transcription]; Region: COG2378 1087453003065 WYL domain; Region: WYL; pfam13280 1087453003066 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1087453003067 Pup-like protein; Region: Pup; pfam05639 1087453003068 Pup-ligase protein; Region: Pup_ligase; cl15463 1087453003069 proteasome ATPase; Region: pup_AAA; TIGR03689 1087453003070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453003071 Walker A motif; other site 1087453003072 ATP binding site [chemical binding]; other site 1087453003073 Walker B motif; other site 1087453003074 arginine finger; other site 1087453003075 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1087453003076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1087453003077 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1087453003078 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1087453003079 active site 1087453003080 metal binding site [ion binding]; metal-binding site 1087453003081 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1087453003082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1087453003083 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1087453003084 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1087453003085 Potassium binding sites [ion binding]; other site 1087453003086 Cesium cation binding sites [ion binding]; other site 1087453003087 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1087453003088 Aspartase; Region: Aspartase; cd01357 1087453003089 active sites [active] 1087453003090 tetramer interface [polypeptide binding]; other site 1087453003091 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1087453003092 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1087453003093 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1087453003094 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1087453003095 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1087453003096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1087453003097 homodimer interface [polypeptide binding]; other site 1087453003098 putative metal binding site [ion binding]; other site 1087453003099 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1087453003100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453003101 motif II; other site 1087453003102 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1087453003103 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1087453003104 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1087453003105 substrate binding pocket [chemical binding]; other site 1087453003106 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1087453003107 B12 binding site [chemical binding]; other site 1087453003108 cobalt ligand [ion binding]; other site 1087453003109 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1087453003110 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1087453003111 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453003112 active site 1087453003113 HIGH motif; other site 1087453003114 nucleotide binding site [chemical binding]; other site 1087453003115 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453003116 active site 1087453003117 KMSKS motif; other site 1087453003118 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1087453003119 tRNA binding surface [nucleotide binding]; other site 1087453003120 anticodon binding site; other site 1087453003121 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1087453003122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1087453003123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1087453003124 active site 1087453003125 catalytic tetrad [active] 1087453003126 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1087453003127 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1087453003128 quinone interaction residues [chemical binding]; other site 1087453003129 active site 1087453003130 catalytic residues [active] 1087453003131 FMN binding site [chemical binding]; other site 1087453003132 substrate binding site [chemical binding]; other site 1087453003133 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1087453003134 substrate binding site [chemical binding]; other site 1087453003135 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1087453003136 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1087453003137 dimerization domain swap beta strand [polypeptide binding]; other site 1087453003138 regulatory protein interface [polypeptide binding]; other site 1087453003139 active site 1087453003140 regulatory phosphorylation site [posttranslational modification]; other site 1087453003141 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1087453003142 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1087453003143 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1087453003144 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1087453003145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453003146 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1087453003147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453003148 NAD(P) binding site [chemical binding]; other site 1087453003149 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1087453003150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453003151 NAD(P) binding site [chemical binding]; other site 1087453003152 active site 1087453003153 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1087453003154 GTP/Mg2+ binding site [chemical binding]; other site 1087453003155 G4 box; other site 1087453003156 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1087453003157 G5 box; other site 1087453003158 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1087453003159 Walker A; other site 1087453003160 G1 box; other site 1087453003161 Switch I region; other site 1087453003162 G2 box; other site 1087453003163 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1087453003164 G4 box; other site 1087453003165 G5 box; other site 1087453003166 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1087453003167 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1087453003168 active site 1087453003169 substrate binding site [chemical binding]; other site 1087453003170 coenzyme B12 binding site [chemical binding]; other site 1087453003171 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1087453003172 B12 binding site [chemical binding]; other site 1087453003173 cobalt ligand [ion binding]; other site 1087453003174 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1087453003175 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1087453003176 heterodimer interface [polypeptide binding]; other site 1087453003177 substrate interaction site [chemical binding]; other site 1087453003178 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1087453003179 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1087453003180 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1087453003181 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1087453003182 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1087453003183 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1087453003184 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1087453003185 ferrochelatase; Reviewed; Region: hemH; PRK00035 1087453003186 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1087453003187 C-terminal domain interface [polypeptide binding]; other site 1087453003188 active site 1087453003189 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1087453003190 active site 1087453003191 N-terminal domain interface [polypeptide binding]; other site 1087453003192 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1087453003193 NlpC/P60 family; Region: NLPC_P60; pfam00877 1087453003194 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1087453003195 aconitate hydratase; Validated; Region: PRK09277 1087453003196 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1087453003197 substrate binding site [chemical binding]; other site 1087453003198 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1087453003199 ligand binding site [chemical binding]; other site 1087453003200 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1087453003201 substrate binding site [chemical binding]; other site 1087453003202 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1087453003203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453003204 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1087453003205 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 1087453003206 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1087453003207 catalytic triad [active] 1087453003208 conserved cys residue [active] 1087453003209 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1087453003210 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1087453003211 AAA ATPase domain; Region: AAA_16; pfam13191 1087453003212 AAA domain; Region: AAA_22; pfam13401 1087453003213 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1087453003214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453003215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453003216 Walker A/P-loop; other site 1087453003217 ATP binding site [chemical binding]; other site 1087453003218 Q-loop/lid; other site 1087453003219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453003220 ABC transporter signature motif; other site 1087453003221 Walker B; other site 1087453003222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453003223 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1087453003224 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1087453003225 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1087453003226 trimerization site [polypeptide binding]; other site 1087453003227 active site 1087453003228 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1087453003229 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1087453003230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087453003231 catalytic residue [active] 1087453003232 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1087453003233 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1087453003234 Walker A/P-loop; other site 1087453003235 ATP binding site [chemical binding]; other site 1087453003236 Q-loop/lid; other site 1087453003237 ABC transporter signature motif; other site 1087453003238 Walker B; other site 1087453003239 D-loop; other site 1087453003240 H-loop/switch region; other site 1087453003241 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1087453003242 FeS assembly protein SufD; Region: sufD; TIGR01981 1087453003243 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1087453003244 FeS assembly protein SufB; Region: sufB; TIGR01980 1087453003245 Predicted transcriptional regulator [Transcription]; Region: COG2345 1087453003246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087453003247 putative DNA binding site [nucleotide binding]; other site 1087453003248 putative Zn2+ binding site [ion binding]; other site 1087453003249 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1087453003250 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087453003251 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087453003252 Walker A/P-loop; other site 1087453003253 ATP binding site [chemical binding]; other site 1087453003254 Q-loop/lid; other site 1087453003255 ABC transporter signature motif; other site 1087453003256 Walker B; other site 1087453003257 D-loop; other site 1087453003258 H-loop/switch region; other site 1087453003259 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1087453003260 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1087453003261 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1087453003262 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1087453003263 UbiA prenyltransferase family; Region: UbiA; pfam01040 1087453003264 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1087453003265 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1087453003266 TPP-binding site [chemical binding]; other site 1087453003267 dimer interface [polypeptide binding]; other site 1087453003268 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1087453003269 PYR/PP interface [polypeptide binding]; other site 1087453003270 dimer interface [polypeptide binding]; other site 1087453003271 TPP binding site [chemical binding]; other site 1087453003272 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1087453003273 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1087453003274 putative active site [active] 1087453003275 transaldolase; Provisional; Region: PRK03903 1087453003276 catalytic residue [active] 1087453003277 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1087453003278 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1087453003279 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1087453003280 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1087453003281 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1087453003282 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1087453003283 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1087453003284 putative active site [active] 1087453003285 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1087453003286 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1087453003287 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1087453003288 triosephosphate isomerase; Provisional; Region: PRK14567 1087453003289 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1087453003290 substrate binding site [chemical binding]; other site 1087453003291 dimer interface [polypeptide binding]; other site 1087453003292 catalytic triad [active] 1087453003293 Phosphoglycerate kinase; Region: PGK; pfam00162 1087453003294 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1087453003295 substrate binding site [chemical binding]; other site 1087453003296 hinge regions; other site 1087453003297 ADP binding site [chemical binding]; other site 1087453003298 catalytic site [active] 1087453003299 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1087453003300 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1087453003301 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1087453003302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1087453003303 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1087453003304 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1087453003305 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1087453003306 phosphate binding site [ion binding]; other site 1087453003307 putative substrate binding pocket [chemical binding]; other site 1087453003308 dimer interface [polypeptide binding]; other site 1087453003309 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1087453003310 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1087453003311 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1087453003312 GIY-YIG motif/motif A; other site 1087453003313 active site 1087453003314 catalytic site [active] 1087453003315 putative DNA binding site [nucleotide binding]; other site 1087453003316 metal binding site [ion binding]; metal-binding site 1087453003317 UvrB/uvrC motif; Region: UVR; pfam02151 1087453003318 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1087453003319 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1087453003320 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1087453003321 homopentamer interface [polypeptide binding]; other site 1087453003322 active site 1087453003323 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1087453003324 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1087453003325 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1087453003326 dimerization interface [polypeptide binding]; other site 1087453003327 active site 1087453003328 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1087453003329 Lumazine binding domain; Region: Lum_binding; pfam00677 1087453003330 Lumazine binding domain; Region: Lum_binding; pfam00677 1087453003331 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1087453003332 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1087453003333 catalytic motif [active] 1087453003334 Zn binding site [ion binding]; other site 1087453003335 RibD C-terminal domain; Region: RibD_C; pfam01872 1087453003336 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1087453003337 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1087453003338 substrate binding site [chemical binding]; other site 1087453003339 hexamer interface [polypeptide binding]; other site 1087453003340 metal binding site [ion binding]; metal-binding site 1087453003341 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1087453003342 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1087453003343 putative RNA binding site [nucleotide binding]; other site 1087453003344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453003345 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1087453003346 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1087453003347 putative active site [active] 1087453003348 substrate binding site [chemical binding]; other site 1087453003349 putative cosubstrate binding site; other site 1087453003350 catalytic site [active] 1087453003351 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1087453003352 substrate binding site [chemical binding]; other site 1087453003353 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1087453003354 active site 1087453003355 catalytic residues [active] 1087453003356 metal binding site [ion binding]; metal-binding site 1087453003357 primosome assembly protein PriA; Provisional; Region: PRK14873 1087453003358 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1087453003359 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1087453003360 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1087453003361 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1087453003362 Flavoprotein; Region: Flavoprotein; pfam02441 1087453003363 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1087453003364 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1087453003365 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1087453003366 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1087453003367 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1087453003368 catalytic site [active] 1087453003369 G-X2-G-X-G-K; other site 1087453003370 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1087453003371 active site 1087453003372 dimer interface [polypeptide binding]; other site 1087453003373 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1087453003374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087453003375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087453003376 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1087453003377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087453003378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087453003379 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1087453003380 IMP binding site; other site 1087453003381 dimer interface [polypeptide binding]; other site 1087453003382 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1087453003383 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1087453003384 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1087453003385 catalytic site [active] 1087453003386 subunit interface [polypeptide binding]; other site 1087453003387 dihydroorotase; Validated; Region: pyrC; PRK09357 1087453003388 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1087453003389 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1087453003390 active site 1087453003391 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1087453003392 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1087453003393 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1087453003394 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1087453003395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453003396 active site 1087453003397 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1087453003398 putative hydrophobic ligand binding site [chemical binding]; other site 1087453003399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453003400 TIGR01777 family protein; Region: yfcH 1087453003401 NAD(P) binding site [chemical binding]; other site 1087453003402 active site 1087453003403 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1087453003404 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1087453003405 putative RNA binding site [nucleotide binding]; other site 1087453003406 elongation factor P; Validated; Region: PRK00529 1087453003407 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1087453003408 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1087453003409 RNA binding site [nucleotide binding]; other site 1087453003410 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1087453003411 RNA binding site [nucleotide binding]; other site 1087453003412 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1087453003413 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1087453003414 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1087453003415 active site 1087453003416 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1087453003417 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1087453003418 trimer interface [polypeptide binding]; other site 1087453003419 active site 1087453003420 dimer interface [polypeptide binding]; other site 1087453003421 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1087453003422 active site 1087453003423 dimer interface [polypeptide binding]; other site 1087453003424 metal binding site [ion binding]; metal-binding site 1087453003425 shikimate kinase; Reviewed; Region: aroK; PRK00131 1087453003426 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1087453003427 ADP binding site [chemical binding]; other site 1087453003428 magnesium binding site [ion binding]; other site 1087453003429 putative shikimate binding site; other site 1087453003430 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1087453003431 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1087453003432 Tetramer interface [polypeptide binding]; other site 1087453003433 active site 1087453003434 FMN-binding site [chemical binding]; other site 1087453003435 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1087453003436 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1087453003437 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1087453003438 shikimate binding site; other site 1087453003439 NAD(P) binding site [chemical binding]; other site 1087453003440 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1087453003441 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1087453003442 dimerization interface [polypeptide binding]; other site 1087453003443 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1087453003444 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1087453003445 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1087453003446 motif 1; other site 1087453003447 active site 1087453003448 motif 2; other site 1087453003449 motif 3; other site 1087453003450 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1087453003451 DHHA1 domain; Region: DHHA1; pfam02272 1087453003452 recombination factor protein RarA; Reviewed; Region: PRK13342 1087453003453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453003454 Walker A motif; other site 1087453003455 ATP binding site [chemical binding]; other site 1087453003456 Walker B motif; other site 1087453003457 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1087453003458 Phosphotransferase enzyme family; Region: APH; pfam01636 1087453003459 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1087453003460 substrate binding site [chemical binding]; other site 1087453003461 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1087453003462 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1087453003463 dimer interface [polypeptide binding]; other site 1087453003464 anticodon binding site; other site 1087453003465 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1087453003466 homodimer interface [polypeptide binding]; other site 1087453003467 motif 1; other site 1087453003468 active site 1087453003469 motif 2; other site 1087453003470 GAD domain; Region: GAD; pfam02938 1087453003471 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087453003472 active site 1087453003473 motif 3; other site 1087453003474 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1087453003475 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1087453003476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453003477 ATP binding site [chemical binding]; other site 1087453003478 putative Mg++ binding site [ion binding]; other site 1087453003479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453003480 nucleotide binding region [chemical binding]; other site 1087453003481 ATP-binding site [chemical binding]; other site 1087453003482 Predicted membrane protein [Function unknown]; Region: COG1511 1087453003483 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1087453003484 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1087453003485 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1087453003486 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1087453003487 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1087453003488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453003489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453003490 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1087453003491 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1087453003492 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1087453003493 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1087453003494 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1087453003495 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1087453003496 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1087453003497 putative active site [active] 1087453003498 putative catalytic site [active] 1087453003499 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1087453003500 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1087453003501 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1087453003502 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1087453003503 dimer interface [polypeptide binding]; other site 1087453003504 motif 1; other site 1087453003505 active site 1087453003506 motif 2; other site 1087453003507 motif 3; other site 1087453003508 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1087453003509 anticodon binding site; other site 1087453003510 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1087453003511 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1087453003512 dimer interface [polypeptide binding]; other site 1087453003513 catalytic triad [active] 1087453003514 peroxidatic and resolving cysteines [active] 1087453003515 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1087453003516 active site 1087453003517 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1087453003518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087453003519 Zn2+ binding site [ion binding]; other site 1087453003520 Mg2+ binding site [ion binding]; other site 1087453003521 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1087453003522 synthetase active site [active] 1087453003523 NTP binding site [chemical binding]; other site 1087453003524 metal binding site [ion binding]; metal-binding site 1087453003525 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1087453003526 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1087453003527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453003528 active site 1087453003529 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087453003530 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1087453003531 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1087453003532 Protein export membrane protein; Region: SecD_SecF; pfam02355 1087453003533 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1087453003534 Protein export membrane protein; Region: SecD_SecF; cl14618 1087453003535 Preprotein translocase subunit; Region: YajC; pfam02699 1087453003536 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1087453003537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453003538 Walker A motif; other site 1087453003539 ATP binding site [chemical binding]; other site 1087453003540 Walker B motif; other site 1087453003541 arginine finger; other site 1087453003542 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1087453003543 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1087453003544 RuvA N terminal domain; Region: RuvA_N; pfam01330 1087453003545 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1087453003546 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1087453003547 active site 1087453003548 putative DNA-binding cleft [nucleotide binding]; other site 1087453003549 dimer interface [polypeptide binding]; other site 1087453003550 hypothetical protein; Validated; Region: PRK00110 1087453003551 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1087453003552 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1087453003553 active site 1087453003554 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1087453003555 catalytic triad [active] 1087453003556 dimer interface [polypeptide binding]; other site 1087453003557 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1087453003558 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1087453003559 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1087453003560 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1087453003561 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087453003562 catalytic residue [active] 1087453003563 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087453003564 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087453003565 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1087453003566 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1087453003567 putative acyl-acceptor binding pocket; other site 1087453003568 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1087453003569 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1087453003570 nucleotide binding site/active site [active] 1087453003571 HIT family signature motif; other site 1087453003572 catalytic residue [active] 1087453003573 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1087453003574 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1087453003575 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1087453003576 active site 1087453003577 dimer interface [polypeptide binding]; other site 1087453003578 motif 1; other site 1087453003579 motif 2; other site 1087453003580 motif 3; other site 1087453003581 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1087453003582 anticodon binding site; other site 1087453003583 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1087453003584 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1087453003585 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1087453003586 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1087453003587 hypothetical protein; Provisional; Region: PRK14059 1087453003588 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1087453003589 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1087453003590 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1087453003591 SelR domain; Region: SelR; pfam01641 1087453003592 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1087453003593 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1087453003594 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1087453003595 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1087453003596 catalytic site [active] 1087453003597 putative active site [active] 1087453003598 putative substrate binding site [chemical binding]; other site 1087453003599 HRDC domain; Region: HRDC; pfam00570 1087453003600 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1087453003601 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1087453003602 TPP-binding site; other site 1087453003603 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1087453003604 PYR/PP interface [polypeptide binding]; other site 1087453003605 dimer interface [polypeptide binding]; other site 1087453003606 TPP binding site [chemical binding]; other site 1087453003607 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1087453003608 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1087453003609 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1087453003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453003611 S-adenosylmethionine binding site [chemical binding]; other site 1087453003612 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1087453003613 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1087453003614 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1087453003615 trimer interface [polypeptide binding]; other site 1087453003616 active site 1087453003617 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1087453003618 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1087453003619 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087453003620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1087453003621 nucleotide binding site [chemical binding]; other site 1087453003622 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1087453003623 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1087453003624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453003625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1087453003626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453003627 DNA binding residues [nucleotide binding] 1087453003628 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1087453003629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453003630 ATP binding site [chemical binding]; other site 1087453003631 putative Mg++ binding site [ion binding]; other site 1087453003632 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1087453003633 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1087453003634 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1087453003635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453003636 S-adenosylmethionine binding site [chemical binding]; other site 1087453003637 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1087453003638 putative active site [active] 1087453003639 dimerization interface [polypeptide binding]; other site 1087453003640 putative tRNAtyr binding site [nucleotide binding]; other site 1087453003641 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1087453003642 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1087453003643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453003644 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1087453003645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453003646 DNA binding residues [nucleotide binding] 1087453003647 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1087453003648 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1087453003649 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1087453003650 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1087453003651 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1087453003652 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1087453003653 NAD binding site [chemical binding]; other site 1087453003654 homodimer interface [polypeptide binding]; other site 1087453003655 active site 1087453003656 substrate binding site [chemical binding]; other site 1087453003657 PAC2 family; Region: PAC2; pfam09754 1087453003658 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1087453003659 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1087453003660 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1087453003661 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1087453003662 dimer interface [polypeptide binding]; other site 1087453003663 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1087453003664 catalytic triad [active] 1087453003665 peroxidatic and resolving cysteines [active] 1087453003666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1087453003667 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1087453003668 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1087453003669 dimerization interface [polypeptide binding]; other site 1087453003670 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1087453003671 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1087453003672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453003673 ATP binding site [chemical binding]; other site 1087453003674 putative Mg++ binding site [ion binding]; other site 1087453003675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087453003676 nucleotide binding region [chemical binding]; other site 1087453003677 ATP-binding site [chemical binding]; other site 1087453003678 Helicase associated domain (HA2); Region: HA2; pfam04408 1087453003679 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1087453003680 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1087453003681 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1087453003682 ATP cone domain; Region: ATP-cone; pfam03477 1087453003683 LexA repressor; Validated; Region: PRK00215 1087453003684 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1087453003685 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1087453003686 Catalytic site [active] 1087453003687 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1087453003688 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1087453003689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1087453003690 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1087453003691 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1087453003692 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1087453003693 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1087453003694 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1087453003695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087453003696 DNA-binding site [nucleotide binding]; DNA binding site 1087453003697 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1087453003698 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1087453003699 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1087453003700 putative substrate binding site [chemical binding]; other site 1087453003701 putative ATP binding site [chemical binding]; other site 1087453003702 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1087453003703 active site 1087453003704 phosphorylation site [posttranslational modification] 1087453003705 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1087453003706 active site 1087453003707 P-loop; other site 1087453003708 phosphorylation site [posttranslational modification] 1087453003709 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1087453003710 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1087453003711 dimerization domain swap beta strand [polypeptide binding]; other site 1087453003712 regulatory protein interface [polypeptide binding]; other site 1087453003713 active site 1087453003714 regulatory phosphorylation site [posttranslational modification]; other site 1087453003715 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1087453003716 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1087453003717 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1087453003718 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1087453003719 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1087453003720 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1087453003721 GTPases [General function prediction only]; Region: HflX; COG2262 1087453003722 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1087453003723 HflX GTPase family; Region: HflX; cd01878 1087453003724 G1 box; other site 1087453003725 GTP/Mg2+ binding site [chemical binding]; other site 1087453003726 Switch I region; other site 1087453003727 G2 box; other site 1087453003728 G3 box; other site 1087453003729 Switch II region; other site 1087453003730 G4 box; other site 1087453003731 G5 box; other site 1087453003732 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1087453003733 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1087453003734 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1087453003735 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1087453003736 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1087453003737 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1087453003738 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1087453003739 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1087453003740 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1087453003741 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1087453003742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453003743 FeS/SAM binding site; other site 1087453003744 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1087453003745 recombinase A; Provisional; Region: recA; PRK09354 1087453003746 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1087453003747 hexamer interface [polypeptide binding]; other site 1087453003748 Walker A motif; other site 1087453003749 ATP binding site [chemical binding]; other site 1087453003750 Walker B motif; other site 1087453003751 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1087453003752 BioY family; Region: BioY; pfam02632 1087453003753 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1087453003754 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1087453003755 Walker A/P-loop; other site 1087453003756 ATP binding site [chemical binding]; other site 1087453003757 Q-loop/lid; other site 1087453003758 ABC transporter signature motif; other site 1087453003759 Walker B; other site 1087453003760 D-loop; other site 1087453003761 H-loop/switch region; other site 1087453003762 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1087453003763 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1087453003764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1087453003765 sequence-specific DNA binding site [nucleotide binding]; other site 1087453003766 salt bridge; other site 1087453003767 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1087453003768 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1087453003769 YCII-related domain; Region: YCII; cl00999 1087453003770 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1087453003771 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1087453003772 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1087453003773 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1087453003774 TIGR03085 family protein; Region: TIGR03085 1087453003775 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1087453003776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1087453003777 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1087453003778 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1087453003779 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1087453003780 dimer interface [polypeptide binding]; other site 1087453003781 active site 1087453003782 catalytic residue [active] 1087453003783 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1087453003784 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1087453003785 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1087453003786 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1087453003787 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1087453003788 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1087453003789 oligomer interface [polypeptide binding]; other site 1087453003790 RNA binding site [nucleotide binding]; other site 1087453003791 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1087453003792 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1087453003793 RNase E interface [polypeptide binding]; other site 1087453003794 trimer interface [polypeptide binding]; other site 1087453003795 active site 1087453003796 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1087453003797 putative nucleic acid binding region [nucleotide binding]; other site 1087453003798 G-X-X-G motif; other site 1087453003799 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1087453003800 RNA binding site [nucleotide binding]; other site 1087453003801 domain interface; other site 1087453003802 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1087453003803 16S/18S rRNA binding site [nucleotide binding]; other site 1087453003804 S13e-L30e interaction site [polypeptide binding]; other site 1087453003805 25S rRNA binding site [nucleotide binding]; other site 1087453003806 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1087453003807 active site 1087453003808 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1087453003809 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1087453003810 active site 1087453003811 Riboflavin kinase; Region: Flavokinase; smart00904 1087453003812 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1087453003813 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1087453003814 RNA binding site [nucleotide binding]; other site 1087453003815 active site 1087453003816 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1087453003817 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1087453003818 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1087453003819 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1087453003820 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1087453003821 active site 1087453003822 metal binding site [ion binding]; metal-binding site 1087453003823 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1087453003824 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1087453003825 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1087453003826 DHH family; Region: DHH; pfam01368 1087453003827 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1087453003828 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1087453003829 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1087453003830 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1087453003831 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1087453003832 G1 box; other site 1087453003833 putative GEF interaction site [polypeptide binding]; other site 1087453003834 GTP/Mg2+ binding site [chemical binding]; other site 1087453003835 Switch I region; other site 1087453003836 G2 box; other site 1087453003837 G3 box; other site 1087453003838 Switch II region; other site 1087453003839 G4 box; other site 1087453003840 G5 box; other site 1087453003841 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1087453003842 Translation-initiation factor 2; Region: IF-2; pfam11987 1087453003843 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1087453003844 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1087453003845 putative RNA binding cleft [nucleotide binding]; other site 1087453003846 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1087453003847 NusA N-terminal domain; Region: NusA_N; pfam08529 1087453003848 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1087453003849 RNA binding site [nucleotide binding]; other site 1087453003850 homodimer interface [polypeptide binding]; other site 1087453003851 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1087453003852 G-X-X-G motif; other site 1087453003853 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1087453003854 G-X-X-G motif; other site 1087453003855 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1087453003856 Sm and related proteins; Region: Sm_like; cl00259 1087453003857 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1087453003858 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1087453003859 dimer interface [polypeptide binding]; other site 1087453003860 motif 1; other site 1087453003861 active site 1087453003862 motif 2; other site 1087453003863 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1087453003864 putative deacylase active site [active] 1087453003865 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087453003866 active site 1087453003867 motif 3; other site 1087453003868 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1087453003869 anticodon binding site; other site 1087453003870 hypothetical protein; Validated; Region: PRK02101 1087453003871 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1087453003872 active site 1087453003873 SAM binding site [chemical binding]; other site 1087453003874 homodimer interface [polypeptide binding]; other site 1087453003875 hypothetical protein; Validated; Region: PRK00029 1087453003876 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1087453003877 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1087453003878 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1087453003879 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1087453003880 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1087453003881 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1087453003882 DNA binding site [nucleotide binding] 1087453003883 active site 1087453003884 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1087453003885 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1087453003886 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1087453003887 catalytic triad [active] 1087453003888 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1087453003889 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1087453003890 homodimer interface [polypeptide binding]; other site 1087453003891 Walker A motif; other site 1087453003892 ATP binding site [chemical binding]; other site 1087453003893 hydroxycobalamin binding site [chemical binding]; other site 1087453003894 Walker B motif; other site 1087453003895 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1087453003896 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1087453003897 metal ion-dependent adhesion site (MIDAS); other site 1087453003898 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1087453003899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453003900 Walker A motif; other site 1087453003901 ATP binding site [chemical binding]; other site 1087453003902 Walker B motif; other site 1087453003903 arginine finger; other site 1087453003904 malate:quinone oxidoreductase; Validated; Region: PRK05257 1087453003905 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1087453003906 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1087453003907 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087453003908 mycothione reductase; Reviewed; Region: PRK07846 1087453003909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087453003910 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1087453003911 cobyric acid synthase; Provisional; Region: PRK00784 1087453003912 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1087453003913 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1087453003914 catalytic triad [active] 1087453003915 methionine aminopeptidase; Provisional; Region: PRK12318 1087453003916 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1087453003917 active site 1087453003918 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1087453003919 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1087453003920 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1087453003921 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1087453003922 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1087453003923 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1087453003924 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1087453003925 active site 1087453003926 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1087453003927 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1087453003928 putative substrate binding region [chemical binding]; other site 1087453003929 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1087453003930 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1087453003931 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1087453003932 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1087453003933 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1087453003934 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1087453003935 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1087453003936 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1087453003937 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1087453003938 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1087453003939 hinge region; other site 1087453003940 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1087453003941 putative nucleotide binding site [chemical binding]; other site 1087453003942 uridine monophosphate binding site [chemical binding]; other site 1087453003943 homohexameric interface [polypeptide binding]; other site 1087453003944 elongation factor Ts; Provisional; Region: tsf; PRK09377 1087453003945 UBA/TS-N domain; Region: UBA; pfam00627 1087453003946 Elongation factor TS; Region: EF_TS; pfam00889 1087453003947 Elongation factor TS; Region: EF_TS; pfam00889 1087453003948 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1087453003949 rRNA interaction site [nucleotide binding]; other site 1087453003950 S8 interaction site; other site 1087453003951 putative laminin-1 binding site; other site 1087453003952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1087453003953 Peptidase family M23; Region: Peptidase_M23; pfam01551 1087453003954 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1087453003955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1087453003956 active site 1087453003957 DNA binding site [nucleotide binding] 1087453003958 Int/Topo IB signature motif; other site 1087453003959 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1087453003960 DNA protecting protein DprA; Region: dprA; TIGR00732 1087453003961 hypothetical protein; Reviewed; Region: PRK12497 1087453003962 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1087453003963 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1087453003964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453003965 Walker A motif; other site 1087453003966 ATP binding site [chemical binding]; other site 1087453003967 Walker B motif; other site 1087453003968 arginine finger; other site 1087453003969 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1087453003970 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1087453003971 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1087453003972 RNA/DNA hybrid binding site [nucleotide binding]; other site 1087453003973 active site 1087453003974 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1087453003975 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1087453003976 Catalytic site [active] 1087453003977 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1087453003978 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1087453003979 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1087453003980 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1087453003981 active site 1087453003982 P-loop; other site 1087453003983 phosphorylation site [posttranslational modification] 1087453003984 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1087453003985 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1087453003986 active site 1087453003987 phosphorylation site [posttranslational modification] 1087453003988 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1087453003989 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1087453003990 RimM N-terminal domain; Region: RimM; pfam01782 1087453003991 PRC-barrel domain; Region: PRC; pfam05239 1087453003992 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1087453003993 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1087453003994 signal recognition particle protein; Provisional; Region: PRK10867 1087453003995 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1087453003996 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1087453003997 P loop; other site 1087453003998 GTP binding site [chemical binding]; other site 1087453003999 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1087453004000 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1087453004001 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087453004002 metal binding triad; other site 1087453004003 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1087453004004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087453004005 Zn2+ binding site [ion binding]; other site 1087453004006 Mg2+ binding site [ion binding]; other site 1087453004007 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1087453004008 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1087453004009 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1087453004010 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1087453004011 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1087453004012 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1087453004013 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1087453004014 Walker A/P-loop; other site 1087453004015 ATP binding site [chemical binding]; other site 1087453004016 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1087453004017 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1087453004018 ABC transporter signature motif; other site 1087453004019 Walker B; other site 1087453004020 D-loop; other site 1087453004021 H-loop/switch region; other site 1087453004022 Acylphosphatase; Region: Acylphosphatase; cl00551 1087453004023 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1087453004024 amino acid carrier protein; Region: agcS; TIGR00835 1087453004025 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1087453004026 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1087453004027 DNA binding site [nucleotide binding] 1087453004028 catalytic residue [active] 1087453004029 H2TH interface [polypeptide binding]; other site 1087453004030 putative catalytic residues [active] 1087453004031 turnover-facilitating residue; other site 1087453004032 intercalation triad [nucleotide binding]; other site 1087453004033 8OG recognition residue [nucleotide binding]; other site 1087453004034 putative reading head residues; other site 1087453004035 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1087453004036 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1087453004037 ribonuclease III; Reviewed; Region: rnc; PRK00102 1087453004038 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1087453004039 dimerization interface [polypeptide binding]; other site 1087453004040 active site 1087453004041 metal binding site [ion binding]; metal-binding site 1087453004042 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1087453004043 dsRNA binding site [nucleotide binding]; other site 1087453004044 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1087453004045 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1087453004046 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1087453004047 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1087453004048 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1087453004049 hexamer interface [polypeptide binding]; other site 1087453004050 ligand binding site [chemical binding]; other site 1087453004051 putative active site [active] 1087453004052 NAD(P) binding site [chemical binding]; other site 1087453004053 glutamate dehydrogenase; Provisional; Region: PRK09414 1087453004054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1087453004055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1087453004056 NAD(P) binding site [chemical binding]; other site 1087453004057 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1087453004058 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1087453004059 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1087453004060 nucleotide binding site/active site [active] 1087453004061 HIT family signature motif; other site 1087453004062 catalytic residue [active] 1087453004063 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1087453004064 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1087453004065 metal binding site [ion binding]; metal-binding site 1087453004066 putative dimer interface [polypeptide binding]; other site 1087453004067 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1087453004068 homodimer interface [polypeptide binding]; other site 1087453004069 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1087453004070 active site pocket [active] 1087453004071 Electron transfer DM13; Region: DM13; pfam10517 1087453004072 pyruvate kinase; Provisional; Region: PRK06247 1087453004073 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1087453004074 domain interfaces; other site 1087453004075 active site 1087453004076 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1087453004077 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1087453004078 active site 1087453004079 ribulose/triose binding site [chemical binding]; other site 1087453004080 phosphate binding site [ion binding]; other site 1087453004081 substrate (anthranilate) binding pocket [chemical binding]; other site 1087453004082 product (indole) binding pocket [chemical binding]; other site 1087453004083 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1087453004084 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1087453004085 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1087453004086 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1087453004087 substrate binding site [chemical binding]; other site 1087453004088 glutamase interaction surface [polypeptide binding]; other site 1087453004089 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1087453004090 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087453004091 active site 1087453004092 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1087453004093 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1087453004094 catalytic residues [active] 1087453004095 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1087453004096 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1087453004097 putative active site [active] 1087453004098 oxyanion strand; other site 1087453004099 catalytic triad [active] 1087453004100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453004101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453004102 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1087453004103 putative active site pocket [active] 1087453004104 4-fold oligomerization interface [polypeptide binding]; other site 1087453004105 metal binding residues [ion binding]; metal-binding site 1087453004106 3-fold/trimer interface [polypeptide binding]; other site 1087453004107 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1087453004108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087453004109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453004110 homodimer interface [polypeptide binding]; other site 1087453004111 catalytic residue [active] 1087453004112 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1087453004113 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1087453004114 NAD binding site [chemical binding]; other site 1087453004115 dimerization interface [polypeptide binding]; other site 1087453004116 product binding site; other site 1087453004117 substrate binding site [chemical binding]; other site 1087453004118 zinc binding site [ion binding]; other site 1087453004119 catalytic residues [active] 1087453004120 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1087453004121 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1087453004122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453004123 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1087453004124 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1087453004125 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1087453004126 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1087453004127 active site 1087453004128 catalytic site [active] 1087453004129 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1087453004130 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1087453004131 active site 1087453004132 catalytic site [active] 1087453004133 substrate binding site [chemical binding]; other site 1087453004134 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1087453004135 Dimer interface [polypeptide binding]; other site 1087453004136 BRCT sequence motif; other site 1087453004137 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1087453004138 synthetase active site [active] 1087453004139 NTP binding site [chemical binding]; other site 1087453004140 metal binding site [ion binding]; metal-binding site 1087453004141 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087453004142 RNA binding surface [nucleotide binding]; other site 1087453004143 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1087453004144 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1087453004145 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1087453004146 threonine dehydratase; Validated; Region: PRK08639 1087453004147 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1087453004148 tetramer interface [polypeptide binding]; other site 1087453004149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453004150 catalytic residue [active] 1087453004151 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1087453004152 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1087453004153 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1087453004154 active site 1087453004155 PHP Thumb interface [polypeptide binding]; other site 1087453004156 metal binding site [ion binding]; metal-binding site 1087453004157 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1087453004158 generic binding surface I; other site 1087453004159 generic binding surface II; other site 1087453004160 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1087453004161 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1087453004162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1087453004163 RNA binding surface [nucleotide binding]; other site 1087453004164 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1087453004165 active site 1087453004166 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1087453004167 lipoprotein signal peptidase; Provisional; Region: PRK14787 1087453004168 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1087453004169 active site 1087453004170 homodimer interface [polypeptide binding]; other site 1087453004171 homotetramer interface [polypeptide binding]; other site 1087453004172 DNA polymerase IV; Provisional; Region: PRK03348 1087453004173 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1087453004174 active site 1087453004175 DNA binding site [nucleotide binding] 1087453004176 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1087453004177 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1087453004178 HIGH motif; other site 1087453004179 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1087453004180 active site 1087453004181 KMSKS motif; other site 1087453004182 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1087453004183 tRNA binding surface [nucleotide binding]; other site 1087453004184 anticodon binding site; other site 1087453004185 DivIVA protein; Region: DivIVA; pfam05103 1087453004186 DivIVA domain; Region: DivI1A_domain; TIGR03544 1087453004187 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1087453004188 YGGT family; Region: YGGT; pfam02325 1087453004189 Protein of unknown function (DUF552); Region: DUF552; cl00775 1087453004190 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1087453004191 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1087453004192 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1087453004193 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1087453004194 nucleotide binding site [chemical binding]; other site 1087453004195 SulA interaction site; other site 1087453004196 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1087453004197 Cell division protein FtsQ; Region: FtsQ; pfam03799 1087453004198 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1087453004199 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1087453004200 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453004201 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087453004202 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1087453004203 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1087453004204 homodimer interface [polypeptide binding]; other site 1087453004205 active site 1087453004206 cell division protein FtsW; Region: ftsW; TIGR02614 1087453004207 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1087453004208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453004209 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1087453004210 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1087453004211 Mg++ binding site [ion binding]; other site 1087453004212 putative catalytic motif [active] 1087453004213 putative substrate binding site [chemical binding]; other site 1087453004214 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1087453004215 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1087453004216 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453004217 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087453004218 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1087453004219 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1087453004220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453004221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087453004222 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1087453004223 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1087453004224 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1087453004225 MraW methylase family; Region: Methyltransf_5; cl17771 1087453004226 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1087453004227 cell division protein MraZ; Reviewed; Region: PRK00326 1087453004228 MraZ protein; Region: MraZ; pfam02381 1087453004229 MraZ protein; Region: MraZ; pfam02381 1087453004230 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1087453004231 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1087453004232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1087453004233 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1087453004234 FAD binding site [chemical binding]; other site 1087453004235 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1087453004236 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1087453004237 substrate binding pocket [chemical binding]; other site 1087453004238 chain length determination region; other site 1087453004239 substrate-Mg2+ binding site; other site 1087453004240 catalytic residues [active] 1087453004241 aspartate-rich region 1; other site 1087453004242 active site lid residues [active] 1087453004243 aspartate-rich region 2; other site 1087453004244 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1087453004245 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087453004246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1087453004247 active site 1087453004248 ATP binding site [chemical binding]; other site 1087453004249 substrate binding site [chemical binding]; other site 1087453004250 activation loop (A-loop); other site 1087453004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1087453004252 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453004253 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453004254 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453004255 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087453004256 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1087453004257 Predicted membrane protein [Function unknown]; Region: COG4763 1087453004258 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1087453004259 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1087453004260 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1087453004261 putative acyl-acceptor binding pocket; other site 1087453004262 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087453004263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1087453004264 nucleotide binding site [chemical binding]; other site 1087453004265 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087453004266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087453004267 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1087453004268 NlpC/P60 family; Region: NLPC_P60; pfam00877 1087453004269 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1087453004270 NlpC/P60 family; Region: NLPC_P60; pfam00877 1087453004271 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1087453004272 heme bH binding site [chemical binding]; other site 1087453004273 intrachain domain interface; other site 1087453004274 heme bL binding site [chemical binding]; other site 1087453004275 interchain domain interface [polypeptide binding]; other site 1087453004276 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1087453004277 Qo binding site; other site 1087453004278 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1087453004279 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1087453004280 iron-sulfur cluster [ion binding]; other site 1087453004281 [2Fe-2S] cluster binding site [ion binding]; other site 1087453004282 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1087453004283 Cytochrome c; Region: Cytochrom_C; pfam00034 1087453004284 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1087453004285 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1087453004286 Subunit I/III interface [polypeptide binding]; other site 1087453004287 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1087453004288 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1087453004289 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1087453004290 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1087453004291 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1087453004292 active site 1087453004293 dimer interface [polypeptide binding]; other site 1087453004294 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1087453004295 Ligand Binding Site [chemical binding]; other site 1087453004296 Molecular Tunnel; other site 1087453004297 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1087453004298 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1087453004299 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1087453004300 homotrimer interface [polypeptide binding]; other site 1087453004301 Walker A motif; other site 1087453004302 GTP binding site [chemical binding]; other site 1087453004303 Walker B motif; other site 1087453004304 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1087453004305 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1087453004306 putative dimer interface [polypeptide binding]; other site 1087453004307 active site pocket [active] 1087453004308 putative cataytic base [active] 1087453004309 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1087453004310 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1087453004311 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1087453004312 homodimer interface [polypeptide binding]; other site 1087453004313 substrate-cofactor binding pocket; other site 1087453004314 catalytic residue [active] 1087453004315 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1087453004316 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1087453004317 interface (dimer of trimers) [polypeptide binding]; other site 1087453004318 Substrate-binding/catalytic site; other site 1087453004319 Zn-binding sites [ion binding]; other site 1087453004320 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1087453004321 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1087453004322 E3 interaction surface; other site 1087453004323 lipoyl attachment site [posttranslational modification]; other site 1087453004324 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1087453004325 E3 interaction surface; other site 1087453004326 lipoyl attachment site [posttranslational modification]; other site 1087453004327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1087453004328 E3 interaction surface; other site 1087453004329 lipoyl attachment site [posttranslational modification]; other site 1087453004330 e3 binding domain; Region: E3_binding; pfam02817 1087453004331 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1087453004332 glycine dehydrogenase; Provisional; Region: PRK05367 1087453004333 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1087453004334 tetramer interface [polypeptide binding]; other site 1087453004335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453004336 catalytic residue [active] 1087453004337 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1087453004338 tetramer interface [polypeptide binding]; other site 1087453004339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453004340 catalytic residue [active] 1087453004341 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1087453004342 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1087453004343 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1087453004344 lipoyl attachment site [posttranslational modification]; other site 1087453004345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1087453004346 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087453004347 active site 1087453004348 lipoate-protein ligase B; Provisional; Region: PRK14345 1087453004349 lipoyl synthase; Provisional; Region: PRK05481 1087453004350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453004351 FeS/SAM binding site; other site 1087453004352 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1087453004353 RDD family; Region: RDD; pfam06271 1087453004354 glutamine synthetase, type I; Region: GlnA; TIGR00653 1087453004355 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1087453004356 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1087453004357 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1087453004358 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1087453004359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453004360 DNA binding residues [nucleotide binding] 1087453004361 AAA domain; Region: AAA_23; pfam13476 1087453004362 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1087453004363 DNA methylase; Region: N6_N4_Mtase; pfam01555 1087453004364 DNA methylase; Region: N6_N4_Mtase; cl17433 1087453004365 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1087453004366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453004367 AAA domain; Region: AAA_21; pfam13304 1087453004368 Walker A/P-loop; other site 1087453004369 ATP binding site [chemical binding]; other site 1087453004370 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1087453004371 putative active site [active] 1087453004372 putative metal-binding site [ion binding]; other site 1087453004373 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1087453004374 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1087453004375 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1087453004376 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1087453004377 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1087453004378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087453004379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087453004380 Walker A/P-loop; other site 1087453004381 ATP binding site [chemical binding]; other site 1087453004382 Q-loop/lid; other site 1087453004383 ABC transporter signature motif; other site 1087453004384 Walker B; other site 1087453004385 D-loop; other site 1087453004386 H-loop/switch region; other site 1087453004387 Htaa; Region: HtaA; pfam04213 1087453004388 Htaa; Region: HtaA; pfam04213 1087453004389 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1087453004390 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1087453004391 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1087453004392 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1087453004393 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1087453004394 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1087453004395 active site 1087453004396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1087453004397 Predicted permease [General function prediction only]; Region: COG2056 1087453004398 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1087453004399 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1087453004400 nudix motif; other site 1087453004401 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1087453004402 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1087453004403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453004404 catalytic residue [active] 1087453004405 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1087453004406 active site 1087453004407 catalytic site [active] 1087453004408 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1087453004409 heme binding pocket [chemical binding]; other site 1087453004410 heme ligand [chemical binding]; other site 1087453004411 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1087453004412 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087453004413 metal binding triad; other site 1087453004414 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1087453004415 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087453004416 metal binding triad; other site 1087453004417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1087453004418 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1087453004419 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1087453004420 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1087453004421 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1087453004422 putative active site; other site 1087453004423 putative metal binding residues [ion binding]; other site 1087453004424 signature motif; other site 1087453004425 putative triphosphate binding site [ion binding]; other site 1087453004426 CHAD domain; Region: CHAD; pfam05235 1087453004427 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1087453004428 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1087453004429 RNB domain; Region: RNB; pfam00773 1087453004430 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1087453004431 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1087453004432 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1087453004433 RNA/DNA hybrid binding site [nucleotide binding]; other site 1087453004434 active site 1087453004435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453004436 catalytic core [active] 1087453004437 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1087453004438 Putative zinc ribbon domain; Region: DUF164; pfam02591 1087453004439 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1087453004440 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1087453004441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1087453004442 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1087453004443 hypothetical protein; Provisional; Region: PRK07908 1087453004444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087453004445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453004446 homodimer interface [polypeptide binding]; other site 1087453004447 catalytic residue [active] 1087453004448 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1087453004449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453004450 motif II; other site 1087453004451 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1087453004452 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1087453004453 active site 1087453004454 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1087453004455 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1087453004456 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1087453004457 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1087453004458 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1087453004459 dimer interface [polypeptide binding]; other site 1087453004460 TPP-binding site [chemical binding]; other site 1087453004461 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1087453004462 Serine hydrolase; Region: Ser_hydrolase; cl17834 1087453004463 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1087453004464 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1087453004465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453004466 active site 1087453004467 motif I; other site 1087453004468 motif II; other site 1087453004469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453004470 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1087453004471 Beta-lactamase; Region: Beta-lactamase; pfam00144 1087453004472 Predicted membrane protein [Function unknown]; Region: COG2860 1087453004473 UPF0126 domain; Region: UPF0126; pfam03458 1087453004474 UPF0126 domain; Region: UPF0126; pfam03458 1087453004475 DNA primase; Validated; Region: dnaG; PRK05667 1087453004476 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1087453004477 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1087453004478 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1087453004479 active site 1087453004480 metal binding site [ion binding]; metal-binding site 1087453004481 interdomain interaction site; other site 1087453004482 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1087453004483 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1087453004484 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1087453004485 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1087453004486 glutaminase active site [active] 1087453004487 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1087453004488 dimer interface [polypeptide binding]; other site 1087453004489 active site 1087453004490 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1087453004491 dimer interface [polypeptide binding]; other site 1087453004492 active site 1087453004493 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1087453004494 active site 1087453004495 barstar interaction site; other site 1087453004496 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1087453004497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087453004498 Zn2+ binding site [ion binding]; other site 1087453004499 Mg2+ binding site [ion binding]; other site 1087453004500 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1087453004501 Repair protein; Region: Repair_PSII; pfam04536 1087453004502 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1087453004503 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087453004504 motif 1; other site 1087453004505 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1087453004506 active site 1087453004507 motif 2; other site 1087453004508 motif 3; other site 1087453004509 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1087453004510 anticodon binding site; other site 1087453004511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087453004512 putative DNA binding site [nucleotide binding]; other site 1087453004513 putative Zn2+ binding site [ion binding]; other site 1087453004514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1087453004515 metal binding site 2 [ion binding]; metal-binding site 1087453004516 putative DNA binding helix; other site 1087453004517 metal binding site 1 [ion binding]; metal-binding site 1087453004518 dimer interface [polypeptide binding]; other site 1087453004519 structural Zn2+ binding site [ion binding]; other site 1087453004520 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1087453004521 diiron binding motif [ion binding]; other site 1087453004522 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1087453004523 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1087453004524 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1087453004525 catalytic residue [active] 1087453004526 putative FPP diphosphate binding site; other site 1087453004527 putative FPP binding hydrophobic cleft; other site 1087453004528 dimer interface [polypeptide binding]; other site 1087453004529 putative IPP diphosphate binding site; other site 1087453004530 Recombination protein O N terminal; Region: RecO_N; pfam11967 1087453004531 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1087453004532 Recombination protein O C terminal; Region: RecO_C; pfam02565 1087453004533 GTPase Era; Reviewed; Region: era; PRK00089 1087453004534 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1087453004535 G1 box; other site 1087453004536 GTP/Mg2+ binding site [chemical binding]; other site 1087453004537 Switch I region; other site 1087453004538 G2 box; other site 1087453004539 Switch II region; other site 1087453004540 G3 box; other site 1087453004541 G4 box; other site 1087453004542 G5 box; other site 1087453004543 KH domain; Region: KH_2; pfam07650 1087453004544 pyridoxamine kinase; Validated; Region: PRK05756 1087453004545 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1087453004546 dimer interface [polypeptide binding]; other site 1087453004547 pyridoxal binding site [chemical binding]; other site 1087453004548 ATP binding site [chemical binding]; other site 1087453004549 Domain of unknown function DUF21; Region: DUF21; pfam01595 1087453004550 FOG: CBS domain [General function prediction only]; Region: COG0517 1087453004551 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1087453004552 Transporter associated domain; Region: CorC_HlyC; cl08393 1087453004553 metal-binding heat shock protein; Provisional; Region: PRK00016 1087453004554 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1087453004555 PhoH-like protein; Region: PhoH; pfam02562 1087453004556 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1087453004557 RNA methyltransferase, RsmE family; Region: TIGR00046 1087453004558 chaperone protein DnaJ; Provisional; Region: PRK14278 1087453004559 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1087453004560 HSP70 interaction site [polypeptide binding]; other site 1087453004561 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1087453004562 Zn binding sites [ion binding]; other site 1087453004563 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1087453004564 dimer interface [polypeptide binding]; other site 1087453004565 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1087453004566 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1087453004567 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1087453004568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087453004569 FeS/SAM binding site; other site 1087453004570 HemN C-terminal domain; Region: HemN_C; pfam06969 1087453004571 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1087453004572 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1087453004573 acyl-activating enzyme (AAE) consensus motif; other site 1087453004574 putative AMP binding site [chemical binding]; other site 1087453004575 putative active site [active] 1087453004576 putative CoA binding site [chemical binding]; other site 1087453004577 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1087453004578 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1087453004579 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1087453004580 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1087453004581 active site 1087453004582 Zn binding site [ion binding]; other site 1087453004583 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1087453004584 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1087453004585 substrate binding pocket [chemical binding]; other site 1087453004586 catalytic triad [active] 1087453004587 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1087453004588 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1087453004589 active site 1087453004590 metal binding site [ion binding]; metal-binding site 1087453004591 nudix motif; other site 1087453004592 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1087453004593 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1087453004594 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1087453004595 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087453004596 active site 1087453004597 BCCT family transporter; Region: BCCT; pfam02028 1087453004598 Predicted permeases [General function prediction only]; Region: COG0679 1087453004599 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087453004600 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1087453004601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453004602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453004603 dimer interface [polypeptide binding]; other site 1087453004604 conserved gate region; other site 1087453004605 putative PBP binding loops; other site 1087453004606 ABC-ATPase subunit interface; other site 1087453004607 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1087453004608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453004609 dimer interface [polypeptide binding]; other site 1087453004610 conserved gate region; other site 1087453004611 putative PBP binding loops; other site 1087453004612 ABC-ATPase subunit interface; other site 1087453004613 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1087453004614 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453004615 Walker A/P-loop; other site 1087453004616 ATP binding site [chemical binding]; other site 1087453004617 Q-loop/lid; other site 1087453004618 ABC transporter signature motif; other site 1087453004619 Walker B; other site 1087453004620 D-loop; other site 1087453004621 H-loop/switch region; other site 1087453004622 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453004623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453004624 Walker A/P-loop; other site 1087453004625 ATP binding site [chemical binding]; other site 1087453004626 Q-loop/lid; other site 1087453004627 ABC transporter signature motif; other site 1087453004628 Walker B; other site 1087453004629 D-loop; other site 1087453004630 H-loop/switch region; other site 1087453004631 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453004632 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1087453004633 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1087453004634 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087453004635 catalytic residue [active] 1087453004636 Sulphur transport; Region: Sulf_transp; pfam04143 1087453004637 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1087453004638 CPxP motif; other site 1087453004639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453004640 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1087453004641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1087453004642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1087453004643 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1087453004644 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087453004645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453004646 putative substrate translocation pore; other site 1087453004647 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087453004648 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1087453004649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453004650 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1087453004651 Walker A/P-loop; other site 1087453004652 ATP binding site [chemical binding]; other site 1087453004653 Q-loop/lid; other site 1087453004654 ABC transporter signature motif; other site 1087453004655 Walker B; other site 1087453004656 D-loop; other site 1087453004657 H-loop/switch region; other site 1087453004658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1087453004659 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453004660 Walker A/P-loop; other site 1087453004661 ATP binding site [chemical binding]; other site 1087453004662 Q-loop/lid; other site 1087453004663 ABC transporter signature motif; other site 1087453004664 Walker B; other site 1087453004665 D-loop; other site 1087453004666 H-loop/switch region; other site 1087453004667 GTP-binding protein LepA; Provisional; Region: PRK05433 1087453004668 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1087453004669 G1 box; other site 1087453004670 putative GEF interaction site [polypeptide binding]; other site 1087453004671 GTP/Mg2+ binding site [chemical binding]; other site 1087453004672 Switch I region; other site 1087453004673 G2 box; other site 1087453004674 G3 box; other site 1087453004675 Switch II region; other site 1087453004676 G4 box; other site 1087453004677 G5 box; other site 1087453004678 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1087453004679 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1087453004680 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1087453004681 PemK-like protein; Region: PemK; pfam02452 1087453004682 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1087453004683 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1087453004684 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1087453004685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1087453004686 hypothetical protein; Validated; Region: PRK05629 1087453004687 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1087453004688 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1087453004689 Competence protein; Region: Competence; pfam03772 1087453004690 comEA protein; Region: comE; TIGR01259 1087453004691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1087453004692 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1087453004693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453004694 catalytic core [active] 1087453004695 Oligomerisation domain; Region: Oligomerisation; pfam02410 1087453004696 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1087453004697 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1087453004698 active site 1087453004699 (T/H)XGH motif; other site 1087453004700 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1087453004701 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1087453004702 putative catalytic cysteine [active] 1087453004703 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1087453004704 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1087453004705 putative ligand binding site [chemical binding]; other site 1087453004706 putative NAD binding site [chemical binding]; other site 1087453004707 catalytic site [active] 1087453004708 Protein of unknown function (DUF454); Region: DUF454; cl01063 1087453004709 Predicted permease [General function prediction only]; Region: COG2985 1087453004710 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1087453004711 TrkA-C domain; Region: TrkA_C; pfam02080 1087453004712 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1087453004713 gamma-glutamyl kinase; Provisional; Region: PRK05429 1087453004714 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1087453004715 nucleotide binding site [chemical binding]; other site 1087453004716 homotetrameric interface [polypeptide binding]; other site 1087453004717 putative phosphate binding site [ion binding]; other site 1087453004718 putative allosteric binding site; other site 1087453004719 PUA domain; Region: PUA; pfam01472 1087453004720 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1087453004721 GTP1/OBG; Region: GTP1_OBG; pfam01018 1087453004722 Obg GTPase; Region: Obg; cd01898 1087453004723 G1 box; other site 1087453004724 GTP/Mg2+ binding site [chemical binding]; other site 1087453004725 Switch I region; other site 1087453004726 G2 box; other site 1087453004727 G3 box; other site 1087453004728 Switch II region; other site 1087453004729 G4 box; other site 1087453004730 G5 box; other site 1087453004731 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1087453004732 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1087453004733 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1087453004734 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1087453004735 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1087453004736 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1087453004737 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1087453004738 homodimer interface [polypeptide binding]; other site 1087453004739 oligonucleotide binding site [chemical binding]; other site 1087453004740 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1087453004741 active site 1087453004742 multimer interface [polypeptide binding]; other site 1087453004743 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1087453004744 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1087453004745 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1087453004746 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1087453004747 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453004748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087453004749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087453004750 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1087453004751 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453004752 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1087453004753 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1087453004754 active site 1087453004755 KMSKS motif; other site 1087453004756 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1087453004757 tRNA binding surface [nucleotide binding]; other site 1087453004758 anticodon binding site; other site 1087453004759 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1087453004760 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1087453004761 malate dehydrogenase; Provisional; Region: PRK05442 1087453004762 NAD(P) binding site [chemical binding]; other site 1087453004763 dimer interface [polypeptide binding]; other site 1087453004764 malate binding site [chemical binding]; other site 1087453004765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453004766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453004767 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1087453004768 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1087453004769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453004770 Walker A motif; other site 1087453004771 ATP binding site [chemical binding]; other site 1087453004772 Walker B motif; other site 1087453004773 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1087453004774 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1087453004775 glutamine binding [chemical binding]; other site 1087453004776 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1087453004777 catalytic triad [active] 1087453004778 hypothetical protein; Validated; Region: PRK09070 1087453004779 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1087453004780 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1087453004781 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1087453004782 substrate-cofactor binding pocket; other site 1087453004783 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1087453004784 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1087453004785 oligomer interface [polypeptide binding]; other site 1087453004786 active site residues [active] 1087453004787 Clp protease; Region: CLP_protease; pfam00574 1087453004788 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1087453004789 oligomer interface [polypeptide binding]; other site 1087453004790 active site residues [active] 1087453004791 trigger factor; Provisional; Region: tig; PRK01490 1087453004792 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1087453004793 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1087453004794 Pirin-related protein [General function prediction only]; Region: COG1741 1087453004795 Pirin; Region: Pirin; pfam02678 1087453004796 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1087453004797 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1087453004798 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1087453004799 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1087453004800 catalytic residues [active] 1087453004801 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1087453004802 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1087453004803 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1087453004804 apolar tunnel; other site 1087453004805 heme binding site [chemical binding]; other site 1087453004806 dimerization interface [polypeptide binding]; other site 1087453004807 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1087453004808 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1087453004809 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1087453004810 active site 1087453004811 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1087453004812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453004813 Walker A/P-loop; other site 1087453004814 ATP binding site [chemical binding]; other site 1087453004815 Q-loop/lid; other site 1087453004816 ABC transporter signature motif; other site 1087453004817 Walker B; other site 1087453004818 D-loop; other site 1087453004819 H-loop/switch region; other site 1087453004820 ABC transporter; Region: ABC_tran_2; pfam12848 1087453004821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087453004822 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1087453004823 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1087453004824 dimer interface [polypeptide binding]; other site 1087453004825 ssDNA binding site [nucleotide binding]; other site 1087453004826 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1087453004827 YcaO-like family; Region: YcaO; pfam02624 1087453004828 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1087453004829 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1087453004830 FMN binding site [chemical binding]; other site 1087453004831 dimer interface [polypeptide binding]; other site 1087453004832 Nitroreductase family; Region: Nitroreductase; pfam00881 1087453004833 dimer interface [polypeptide binding]; other site 1087453004834 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1087453004835 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1087453004836 YcaO-like family; Region: YcaO; pfam02624 1087453004837 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1087453004838 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087453004839 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087453004840 Walker A/P-loop; other site 1087453004841 ATP binding site [chemical binding]; other site 1087453004842 Q-loop/lid; other site 1087453004843 ABC transporter signature motif; other site 1087453004844 Walker B; other site 1087453004845 D-loop; other site 1087453004846 H-loop/switch region; other site 1087453004847 Copper resistance protein D; Region: CopD; pfam05425 1087453004848 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1087453004849 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1087453004850 Carbon starvation protein CstA; Region: CstA; pfam02554 1087453004851 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1087453004852 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1087453004853 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1087453004854 active site 1087453004855 catalytic triad [active] 1087453004856 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1087453004857 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1087453004858 NADP binding site [chemical binding]; other site 1087453004859 dimer interface [polypeptide binding]; other site 1087453004860 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1087453004861 classical (c) SDRs; Region: SDR_c; cd05233 1087453004862 NAD(P) binding site [chemical binding]; other site 1087453004863 active site 1087453004864 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1087453004865 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1087453004866 catalytic site [active] 1087453004867 putative active site [active] 1087453004868 putative substrate binding site [chemical binding]; other site 1087453004869 dimer interface [polypeptide binding]; other site 1087453004870 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1087453004871 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1087453004872 inhibitor site; inhibition site 1087453004873 active site 1087453004874 dimer interface [polypeptide binding]; other site 1087453004875 catalytic residue [active] 1087453004876 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1087453004877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1087453004878 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1087453004879 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1087453004880 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1087453004881 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1087453004882 NAD(P) binding site [chemical binding]; other site 1087453004883 substrate binding site [chemical binding]; other site 1087453004884 dimer interface [polypeptide binding]; other site 1087453004885 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1087453004886 Isochorismatase family; Region: Isochorismatase; pfam00857 1087453004887 catalytic triad [active] 1087453004888 metal binding site [ion binding]; metal-binding site 1087453004889 conserved cis-peptide bond; other site 1087453004890 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1087453004891 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1087453004892 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1087453004893 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1087453004894 catalytic triad [active] 1087453004895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453004896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453004897 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1087453004898 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1087453004899 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1087453004900 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1087453004901 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1087453004902 phosphate binding site [ion binding]; other site 1087453004903 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1087453004904 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1087453004905 active site 2 [active] 1087453004906 active site 1 [active] 1087453004907 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1087453004908 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1087453004909 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1087453004910 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1087453004911 putative NAD(P) binding site [chemical binding]; other site 1087453004912 active site 1087453004913 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1087453004914 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1087453004915 active site 1087453004916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087453004917 Histidine kinase; Region: HisKA_3; pfam07730 1087453004918 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087453004919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087453004920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453004921 active site 1087453004922 phosphorylation site [posttranslational modification] 1087453004923 intermolecular recognition site; other site 1087453004924 dimerization interface [polypeptide binding]; other site 1087453004925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087453004926 DNA binding residues [nucleotide binding] 1087453004927 dimerization interface [polypeptide binding]; other site 1087453004928 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1087453004929 CAAX protease self-immunity; Region: Abi; pfam02517 1087453004930 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1087453004931 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1087453004932 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1087453004933 active site 1087453004934 dimerization interface [polypeptide binding]; other site 1087453004935 ribonuclease PH; Reviewed; Region: rph; PRK00173 1087453004936 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1087453004937 hexamer interface [polypeptide binding]; other site 1087453004938 active site 1087453004939 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1087453004940 glutamate racemase; Provisional; Region: PRK00865 1087453004941 Rhomboid family; Region: Rhomboid; pfam01694 1087453004942 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1087453004943 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1087453004944 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1087453004945 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1087453004946 active site 1087453004947 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1087453004948 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1087453004949 ATP binding site [chemical binding]; other site 1087453004950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087453004951 putative Mg++ binding site [ion binding]; other site 1087453004952 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1087453004953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1087453004954 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1087453004955 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1087453004956 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1087453004957 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1087453004958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453004959 motif II; other site 1087453004960 Winged helix-turn helix; Region: HTH_29; pfam13551 1087453004961 Helix-turn-helix domain; Region: HTH_28; pfam13518 1087453004962 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1087453004963 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1087453004964 D-pathway; other site 1087453004965 Putative ubiquinol binding site [chemical binding]; other site 1087453004966 Low-spin heme (heme b) binding site [chemical binding]; other site 1087453004967 Putative water exit pathway; other site 1087453004968 Binuclear center (heme o3/CuB) [ion binding]; other site 1087453004969 K-pathway; other site 1087453004970 Putative proton exit pathway; other site 1087453004971 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1087453004972 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1087453004973 dimer interface [polypeptide binding]; other site 1087453004974 putative radical transfer pathway; other site 1087453004975 diiron center [ion binding]; other site 1087453004976 tyrosyl radical; other site 1087453004977 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1087453004978 Ferritin-like domain; Region: Ferritin; pfam00210 1087453004979 ferroxidase diiron center [ion binding]; other site 1087453004980 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1087453004981 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1087453004982 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1087453004983 active site 1087453004984 dimer interface [polypeptide binding]; other site 1087453004985 catalytic residues [active] 1087453004986 effector binding site; other site 1087453004987 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1087453004988 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1087453004989 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1087453004990 catalytic residues [active] 1087453004991 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1087453004992 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1087453004993 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1087453004994 homodimer interface [polypeptide binding]; other site 1087453004995 NAD binding pocket [chemical binding]; other site 1087453004996 ATP binding pocket [chemical binding]; other site 1087453004997 Mg binding site [ion binding]; other site 1087453004998 active-site loop [active] 1087453004999 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1087453005000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087453005001 dimerization interface [polypeptide binding]; other site 1087453005002 putative DNA binding site [nucleotide binding]; other site 1087453005003 putative Zn2+ binding site [ion binding]; other site 1087453005004 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1087453005005 Thioredoxin; Region: Thioredoxin_4; cl17273 1087453005006 Predicted membrane protein [Function unknown]; Region: COG2259 1087453005007 phosphoglucomutase; Validated; Region: PRK07564 1087453005008 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1087453005009 active site 1087453005010 substrate binding site [chemical binding]; other site 1087453005011 metal binding site [ion binding]; metal-binding site 1087453005012 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 1087453005013 CrcB-like protein; Region: CRCB; pfam02537 1087453005014 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1087453005015 FtsX-like permease family; Region: FtsX; pfam02687 1087453005016 FtsX-like permease family; Region: FtsX; pfam02687 1087453005017 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087453005018 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087453005019 Walker A/P-loop; other site 1087453005020 ATP binding site [chemical binding]; other site 1087453005021 Q-loop/lid; other site 1087453005022 ABC transporter signature motif; other site 1087453005023 Walker B; other site 1087453005024 D-loop; other site 1087453005025 H-loop/switch region; other site 1087453005026 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1087453005027 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1087453005028 active site 1087453005029 hinge; other site 1087453005030 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1087453005031 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087453005032 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087453005033 DNA binding residues [nucleotide binding] 1087453005034 dimerization interface [polypeptide binding]; other site 1087453005035 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1087453005036 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1087453005037 dimer interface [polypeptide binding]; other site 1087453005038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453005039 catalytic residue [active] 1087453005040 serine O-acetyltransferase; Region: cysE; TIGR01172 1087453005041 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1087453005042 trimer interface [polypeptide binding]; other site 1087453005043 active site 1087453005044 substrate binding site [chemical binding]; other site 1087453005045 CoA binding site [chemical binding]; other site 1087453005046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453005047 Coenzyme A binding pocket [chemical binding]; other site 1087453005048 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1087453005049 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1087453005050 putative active site [active] 1087453005051 metal binding site [ion binding]; metal-binding site 1087453005052 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1087453005053 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1087453005054 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1087453005055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087453005056 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1087453005057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453005058 Walker A/P-loop; other site 1087453005059 ATP binding site [chemical binding]; other site 1087453005060 Q-loop/lid; other site 1087453005061 ABC transporter signature motif; other site 1087453005062 Walker B; other site 1087453005063 D-loop; other site 1087453005064 H-loop/switch region; other site 1087453005065 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1087453005066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453005067 Walker A/P-loop; other site 1087453005068 ATP binding site [chemical binding]; other site 1087453005069 Q-loop/lid; other site 1087453005070 ABC transporter signature motif; other site 1087453005071 Walker B; other site 1087453005072 D-loop; other site 1087453005073 H-loop/switch region; other site 1087453005074 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1087453005075 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1087453005076 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1087453005077 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1087453005078 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1087453005079 FMN binding site [chemical binding]; other site 1087453005080 active site 1087453005081 catalytic residues [active] 1087453005082 substrate binding site [chemical binding]; other site 1087453005083 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1087453005084 PhoU domain; Region: PhoU; pfam01895 1087453005085 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1087453005086 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1087453005087 Walker A/P-loop; other site 1087453005088 ATP binding site [chemical binding]; other site 1087453005089 Q-loop/lid; other site 1087453005090 ABC transporter signature motif; other site 1087453005091 Walker B; other site 1087453005092 D-loop; other site 1087453005093 H-loop/switch region; other site 1087453005094 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1087453005095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453005096 dimer interface [polypeptide binding]; other site 1087453005097 conserved gate region; other site 1087453005098 putative PBP binding loops; other site 1087453005099 ABC-ATPase subunit interface; other site 1087453005100 PBP superfamily domain; Region: PBP_like_2; cl17296 1087453005101 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1087453005102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453005103 Coenzyme A binding pocket [chemical binding]; other site 1087453005104 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1087453005105 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1087453005106 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1087453005107 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1087453005108 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1087453005109 heme-binding site [chemical binding]; other site 1087453005110 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1087453005111 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1087453005112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453005113 catalytic residue [active] 1087453005114 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1087453005115 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1087453005116 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1087453005117 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1087453005118 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1087453005119 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1087453005120 dimerization interface [polypeptide binding]; other site 1087453005121 putative ATP binding site [chemical binding]; other site 1087453005122 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1087453005123 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1087453005124 active site 1087453005125 tetramer interface [polypeptide binding]; other site 1087453005126 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453005127 active site 1087453005128 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1087453005129 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1087453005130 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1087453005131 dimer interface [polypeptide binding]; other site 1087453005132 putative radical transfer pathway; other site 1087453005133 diiron center [ion binding]; other site 1087453005134 tyrosyl radical; other site 1087453005135 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1087453005136 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1087453005137 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1087453005138 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1087453005139 dimerization interface [polypeptide binding]; other site 1087453005140 ATP binding site [chemical binding]; other site 1087453005141 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1087453005142 dimerization interface [polypeptide binding]; other site 1087453005143 ATP binding site [chemical binding]; other site 1087453005144 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1087453005145 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1087453005146 putative active site [active] 1087453005147 catalytic triad [active] 1087453005148 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1087453005149 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1087453005150 catalytic residues [active] 1087453005151 dimer interface [polypeptide binding]; other site 1087453005152 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1087453005153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1087453005154 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1087453005155 ATP binding site [chemical binding]; other site 1087453005156 active site 1087453005157 substrate binding site [chemical binding]; other site 1087453005158 adenylosuccinate lyase; Region: purB; TIGR00928 1087453005159 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1087453005160 tetramer interface [polypeptide binding]; other site 1087453005161 TrkA-N domain; Region: TrkA_N; pfam02254 1087453005162 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1087453005163 TrkA-C domain; Region: TrkA_C; pfam02080 1087453005164 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1087453005165 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1087453005166 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1087453005167 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1087453005168 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1087453005169 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1087453005170 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1087453005171 nucleotide binding site/active site [active] 1087453005172 HIT family signature motif; other site 1087453005173 catalytic residue [active] 1087453005174 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1087453005175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087453005176 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087453005177 dimerization interface [polypeptide binding]; other site 1087453005178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087453005179 dimer interface [polypeptide binding]; other site 1087453005180 phosphorylation site [posttranslational modification] 1087453005181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453005182 ATP binding site [chemical binding]; other site 1087453005183 Mg2+ binding site [ion binding]; other site 1087453005184 G-X-G motif; other site 1087453005185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087453005186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453005187 active site 1087453005188 phosphorylation site [posttranslational modification] 1087453005189 intermolecular recognition site; other site 1087453005190 dimerization interface [polypeptide binding]; other site 1087453005191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087453005192 DNA binding site [nucleotide binding] 1087453005193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453005194 Predicted esterase [General function prediction only]; Region: COG0627 1087453005195 S-formylglutathione hydrolase; Region: PLN02442 1087453005196 xanthine permease; Region: pbuX; TIGR03173 1087453005197 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1087453005198 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1087453005199 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1087453005200 putative active site [active] 1087453005201 pyruvate dehydrogenase; Provisional; Region: PRK06546 1087453005202 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1087453005203 PYR/PP interface [polypeptide binding]; other site 1087453005204 tetramer interface [polypeptide binding]; other site 1087453005205 dimer interface [polypeptide binding]; other site 1087453005206 TPP binding site [chemical binding]; other site 1087453005207 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1087453005208 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1087453005209 TPP-binding site [chemical binding]; other site 1087453005210 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1087453005211 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1087453005212 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1087453005213 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1087453005214 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1087453005215 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1087453005216 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1087453005217 active site 1087453005218 homotetramer interface [polypeptide binding]; other site 1087453005219 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1087453005220 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1087453005221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1087453005222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1087453005223 DNA binding site [nucleotide binding] 1087453005224 domain linker motif; other site 1087453005225 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1087453005226 putative dimerization interface [polypeptide binding]; other site 1087453005227 putative ligand binding site [chemical binding]; other site 1087453005228 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1087453005229 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087453005230 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1087453005231 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087453005232 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1087453005233 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453005234 active site 1087453005235 HIGH motif; other site 1087453005236 nucleotide binding site [chemical binding]; other site 1087453005237 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1087453005238 KMSKS motif; other site 1087453005239 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1087453005240 tRNA binding surface [nucleotide binding]; other site 1087453005241 anticodon binding site; other site 1087453005242 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1087453005243 homotrimer interaction site [polypeptide binding]; other site 1087453005244 zinc binding site [ion binding]; other site 1087453005245 CDP-binding sites; other site 1087453005246 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1087453005247 substrate binding site; other site 1087453005248 dimer interface; other site 1087453005249 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1087453005250 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1087453005251 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1087453005252 Walker A motif; other site 1087453005253 ATP binding site [chemical binding]; other site 1087453005254 Walker B motif; other site 1087453005255 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1087453005256 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1087453005257 active site clefts [active] 1087453005258 zinc binding site [ion binding]; other site 1087453005259 dimer interface [polypeptide binding]; other site 1087453005260 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1087453005261 endonuclease III; Region: ENDO3c; smart00478 1087453005262 minor groove reading motif; other site 1087453005263 helix-hairpin-helix signature motif; other site 1087453005264 substrate binding pocket [chemical binding]; other site 1087453005265 active site 1087453005266 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1087453005267 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1087453005268 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1087453005269 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1087453005270 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1087453005271 Clp amino terminal domain; Region: Clp_N; pfam02861 1087453005272 Clp amino terminal domain; Region: Clp_N; pfam02861 1087453005273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453005274 Walker A motif; other site 1087453005275 ATP binding site [chemical binding]; other site 1087453005276 Walker B motif; other site 1087453005277 arginine finger; other site 1087453005278 UvrB/uvrC motif; Region: UVR; pfam02151 1087453005279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453005280 Walker A motif; other site 1087453005281 ATP binding site [chemical binding]; other site 1087453005282 Walker B motif; other site 1087453005283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1087453005284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453005285 putative substrate translocation pore; other site 1087453005286 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1087453005287 active site 1087453005288 tetramer interface [polypeptide binding]; other site 1087453005289 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087453005290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1087453005291 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1087453005292 CAAX protease self-immunity; Region: Abi; pfam02517 1087453005293 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1087453005294 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1087453005295 dimer interface [polypeptide binding]; other site 1087453005296 putative anticodon binding site; other site 1087453005297 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087453005298 motif 1; other site 1087453005299 dimer interface [polypeptide binding]; other site 1087453005300 active site 1087453005301 motif 2; other site 1087453005302 motif 3; other site 1087453005303 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1087453005304 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1087453005305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1087453005306 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1087453005307 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1087453005308 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1087453005309 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1087453005310 NAD(P) binding site [chemical binding]; other site 1087453005311 catalytic residues [active] 1087453005312 BCCT family transporter; Region: BCCT; cl00569 1087453005313 choline dehydrogenase; Validated; Region: PRK02106 1087453005314 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1087453005315 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1087453005316 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453005317 active site 1087453005318 nucleotide binding site [chemical binding]; other site 1087453005319 HIGH motif; other site 1087453005320 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453005321 KMSKS motif; other site 1087453005322 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1087453005323 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1087453005324 catalytic center binding site [active] 1087453005325 ATP binding site [chemical binding]; other site 1087453005326 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1087453005327 homooctamer interface [polypeptide binding]; other site 1087453005328 active site 1087453005329 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1087453005330 dihydropteroate synthase; Region: DHPS; TIGR01496 1087453005331 substrate binding pocket [chemical binding]; other site 1087453005332 dimer interface [polypeptide binding]; other site 1087453005333 inhibitor binding site; inhibition site 1087453005334 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1087453005335 GTP cyclohydrolase I; Provisional; Region: PLN03044 1087453005336 homodecamer interface [polypeptide binding]; other site 1087453005337 active site 1087453005338 putative catalytic site residues [active] 1087453005339 zinc binding site [ion binding]; other site 1087453005340 GTP-CH-I/GFRP interaction surface; other site 1087453005341 FtsH Extracellular; Region: FtsH_ext; pfam06480 1087453005342 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1087453005343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453005344 Walker A motif; other site 1087453005345 ATP binding site [chemical binding]; other site 1087453005346 Walker B motif; other site 1087453005347 arginine finger; other site 1087453005348 Peptidase family M41; Region: Peptidase_M41; pfam01434 1087453005349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453005350 active site 1087453005351 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1087453005352 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1087453005353 Ligand Binding Site [chemical binding]; other site 1087453005354 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1087453005355 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1087453005356 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1087453005357 dimer interface [polypeptide binding]; other site 1087453005358 substrate binding site [chemical binding]; other site 1087453005359 metal binding sites [ion binding]; metal-binding site 1087453005360 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1087453005361 active site residue [active] 1087453005362 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1087453005363 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1087453005364 Secretory lipase; Region: LIP; pfam03583 1087453005365 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1087453005366 MarR family; Region: MarR_2; pfam12802 1087453005367 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087453005368 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1087453005369 acyl-activating enzyme (AAE) consensus motif; other site 1087453005370 AMP binding site [chemical binding]; other site 1087453005371 active site 1087453005372 CoA binding site [chemical binding]; other site 1087453005373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1087453005374 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1087453005375 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087453005376 putative trimer interface [polypeptide binding]; other site 1087453005377 putative CoA binding site [chemical binding]; other site 1087453005378 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087453005379 putative trimer interface [polypeptide binding]; other site 1087453005380 putative CoA binding site [chemical binding]; other site 1087453005381 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1087453005382 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1087453005383 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1087453005384 ring oligomerisation interface [polypeptide binding]; other site 1087453005385 ATP/Mg binding site [chemical binding]; other site 1087453005386 stacking interactions; other site 1087453005387 hinge regions; other site 1087453005388 hypothetical protein; Provisional; Region: PRK07907 1087453005389 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1087453005390 active site 1087453005391 metal binding site [ion binding]; metal-binding site 1087453005392 dimer interface [polypeptide binding]; other site 1087453005393 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1087453005394 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087453005395 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1087453005396 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1087453005397 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1087453005398 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1087453005399 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1087453005400 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087453005401 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1087453005402 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1087453005403 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1087453005404 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1087453005405 carboxylate-amine ligase; Provisional; Region: PRK13517 1087453005406 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1087453005407 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1087453005408 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1087453005409 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1087453005410 active site 1087453005411 catalytic residues [active] 1087453005412 metal binding site [ion binding]; metal-binding site 1087453005413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087453005414 Coenzyme A binding pocket [chemical binding]; other site 1087453005415 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1087453005416 putative catalytic site [active] 1087453005417 putative phosphate binding site [ion binding]; other site 1087453005418 active site 1087453005419 metal binding site A [ion binding]; metal-binding site 1087453005420 DNA binding site [nucleotide binding] 1087453005421 putative AP binding site [nucleotide binding]; other site 1087453005422 putative metal binding site B [ion binding]; other site 1087453005423 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1087453005424 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1087453005425 putative active site [active] 1087453005426 catalytic site [active] 1087453005427 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1087453005428 putative active site [active] 1087453005429 catalytic site [active] 1087453005430 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1087453005431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087453005432 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1087453005433 Walker A/P-loop; other site 1087453005434 ATP binding site [chemical binding]; other site 1087453005435 Q-loop/lid; other site 1087453005436 ABC transporter signature motif; other site 1087453005437 Walker B; other site 1087453005438 D-loop; other site 1087453005439 H-loop/switch region; other site 1087453005440 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1087453005441 nudix motif; other site 1087453005442 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1087453005443 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1087453005444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1087453005445 substrate binding pocket [chemical binding]; other site 1087453005446 membrane-bound complex binding site; other site 1087453005447 hinge residues; other site 1087453005448 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087453005449 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1087453005450 active site 1087453005451 ATP binding site [chemical binding]; other site 1087453005452 substrate binding site [chemical binding]; other site 1087453005453 activation loop (A-loop); other site 1087453005454 propionate/acetate kinase; Provisional; Region: PRK12379 1087453005455 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1087453005456 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1087453005457 ferredoxin-NADP+ reductase; Region: PLN02852 1087453005458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087453005459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1087453005460 Coenzyme A binding pocket [chemical binding]; other site 1087453005461 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087453005462 active site 1087453005463 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1087453005464 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087453005465 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453005466 active site 1087453005467 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1087453005468 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087453005469 catalytic residues [active] 1087453005470 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1087453005471 ResB-like family; Region: ResB; pfam05140 1087453005472 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1087453005473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1087453005474 TPR motif; other site 1087453005475 TPR repeat; Region: TPR_11; pfam13414 1087453005476 binding surface 1087453005477 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1087453005478 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1087453005479 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1087453005480 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1087453005481 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1087453005482 GDP-binding site [chemical binding]; other site 1087453005483 ACT binding site; other site 1087453005484 IMP binding site; other site 1087453005485 Predicted membrane protein [Function unknown]; Region: COG4129 1087453005486 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1087453005487 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1087453005488 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087453005489 Walker A/P-loop; other site 1087453005490 ATP binding site [chemical binding]; other site 1087453005491 Q-loop/lid; other site 1087453005492 ABC transporter signature motif; other site 1087453005493 Walker B; other site 1087453005494 D-loop; other site 1087453005495 H-loop/switch region; other site 1087453005496 Predicted transcriptional regulators [Transcription]; Region: COG1695 1087453005497 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1087453005498 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1087453005499 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1087453005500 active site 1087453005501 intersubunit interface [polypeptide binding]; other site 1087453005502 zinc binding site [ion binding]; other site 1087453005503 Na+ binding site [ion binding]; other site 1087453005504 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1087453005505 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087453005506 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087453005507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087453005508 active site 1087453005509 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1087453005510 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1087453005511 Gram positive anchor; Region: Gram_pos_anchor; cl15427 1087453005512 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1087453005513 active site 1087453005514 catalytic site [active] 1087453005515 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1087453005516 Cna protein B-type domain; Region: Cna_B; pfam05738 1087453005517 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1087453005518 active site 1087453005519 catalytic site [active] 1087453005520 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1087453005521 Clp amino terminal domain; Region: Clp_N; pfam02861 1087453005522 Clp amino terminal domain; Region: Clp_N; pfam02861 1087453005523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453005524 Walker A motif; other site 1087453005525 ATP binding site [chemical binding]; other site 1087453005526 Walker B motif; other site 1087453005527 arginine finger; other site 1087453005528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087453005529 Walker A motif; other site 1087453005530 ATP binding site [chemical binding]; other site 1087453005531 Walker B motif; other site 1087453005532 arginine finger; other site 1087453005533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1087453005534 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1087453005535 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087453005536 Walker A/P-loop; other site 1087453005537 ATP binding site [chemical binding]; other site 1087453005538 Q-loop/lid; other site 1087453005539 ABC transporter signature motif; other site 1087453005540 Walker B; other site 1087453005541 D-loop; other site 1087453005542 H-loop/switch region; other site 1087453005543 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1087453005544 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1087453005545 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1087453005546 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1087453005547 FAD binding pocket [chemical binding]; other site 1087453005548 conserved FAD binding motif [chemical binding]; other site 1087453005549 phosphate binding motif [ion binding]; other site 1087453005550 beta-alpha-beta structure motif; other site 1087453005551 NAD binding pocket [chemical binding]; other site 1087453005552 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1087453005553 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1087453005554 FtsX-like permease family; Region: FtsX; pfam02687 1087453005555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087453005556 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087453005557 Walker A/P-loop; other site 1087453005558 ATP binding site [chemical binding]; other site 1087453005559 Q-loop/lid; other site 1087453005560 ABC transporter signature motif; other site 1087453005561 Walker B; other site 1087453005562 D-loop; other site 1087453005563 H-loop/switch region; other site 1087453005564 HlyD family secretion protein; Region: HlyD_3; pfam13437 1087453005565 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1087453005566 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1087453005567 active site 1087453005568 catalytic triad [active] 1087453005569 dimer interface [polypeptide binding]; other site 1087453005570 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1087453005571 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1087453005572 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1087453005573 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1087453005574 NAD binding site [chemical binding]; other site 1087453005575 substrate binding site [chemical binding]; other site 1087453005576 catalytic Zn binding site [ion binding]; other site 1087453005577 tetramer interface [polypeptide binding]; other site 1087453005578 structural Zn binding site [ion binding]; other site 1087453005579 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1087453005580 active site 1087453005581 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1087453005582 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1087453005583 DNA binding residues [nucleotide binding] 1087453005584 chaperone protein DnaJ; Provisional; Region: PRK14279 1087453005585 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1087453005586 HSP70 interaction site [polypeptide binding]; other site 1087453005587 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1087453005588 Zn binding sites [ion binding]; other site 1087453005589 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1087453005590 dimer interface [polypeptide binding]; other site 1087453005591 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1087453005592 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1087453005593 dimer interface [polypeptide binding]; other site 1087453005594 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1087453005595 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1087453005596 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1087453005597 nucleotide binding site [chemical binding]; other site 1087453005598 NEF interaction site [polypeptide binding]; other site 1087453005599 SBD interface [polypeptide binding]; other site 1087453005600 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1087453005601 active site 1087453005602 catalytic site [active] 1087453005603 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1087453005604 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1087453005605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453005606 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1087453005607 Walker A/P-loop; other site 1087453005608 ATP binding site [chemical binding]; other site 1087453005609 Q-loop/lid; other site 1087453005610 ABC transporter signature motif; other site 1087453005611 Walker B; other site 1087453005612 D-loop; other site 1087453005613 H-loop/switch region; other site 1087453005614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453005616 dimer interface [polypeptide binding]; other site 1087453005617 conserved gate region; other site 1087453005618 putative PBP binding loops; other site 1087453005619 ABC-ATPase subunit interface; other site 1087453005620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1087453005621 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1087453005622 adrenodoxin reductase; Provisional; Region: PTZ00188 1087453005623 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1087453005624 4Fe-4S binding domain; Region: Fer4; cl02805 1087453005625 4Fe-4S binding domain; Region: Fer4; pfam00037 1087453005626 Cysteine-rich domain; Region: CCG; pfam02754 1087453005627 Cysteine-rich domain; Region: CCG; pfam02754 1087453005628 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1087453005629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087453005630 dimerization interface [polypeptide binding]; other site 1087453005631 putative DNA binding site [nucleotide binding]; other site 1087453005632 putative Zn2+ binding site [ion binding]; other site 1087453005633 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453005634 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453005635 Walker A/P-loop; other site 1087453005636 ATP binding site [chemical binding]; other site 1087453005637 Q-loop/lid; other site 1087453005638 ABC transporter signature motif; other site 1087453005639 Walker B; other site 1087453005640 D-loop; other site 1087453005641 H-loop/switch region; other site 1087453005642 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087453005643 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453005644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453005645 putative PBP binding regions; other site 1087453005646 ABC-ATPase subunit interface; other site 1087453005647 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1087453005648 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087453005649 intersubunit interface [polypeptide binding]; other site 1087453005650 UreD urease accessory protein; Region: UreD; cl00530 1087453005651 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1087453005652 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1087453005653 UreF; Region: UreF; pfam01730 1087453005654 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1087453005655 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1087453005656 dimer interface [polypeptide binding]; other site 1087453005657 catalytic residues [active] 1087453005658 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1087453005659 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1087453005660 subunit interactions [polypeptide binding]; other site 1087453005661 active site 1087453005662 flap region; other site 1087453005663 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1087453005664 gamma-beta subunit interface [polypeptide binding]; other site 1087453005665 alpha-beta subunit interface [polypeptide binding]; other site 1087453005666 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1087453005667 alpha-gamma subunit interface [polypeptide binding]; other site 1087453005668 beta-gamma subunit interface [polypeptide binding]; other site 1087453005669 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1087453005670 EamA-like transporter family; Region: EamA; pfam00892 1087453005671 EamA-like transporter family; Region: EamA; pfam00892 1087453005672 aminotransferase AlaT; Validated; Region: PRK09265 1087453005673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087453005674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453005675 homodimer interface [polypeptide binding]; other site 1087453005676 catalytic residue [active] 1087453005677 YibE/F-like protein; Region: YibE_F; pfam07907 1087453005678 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1087453005679 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1087453005680 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1087453005681 dimer interface [polypeptide binding]; other site 1087453005682 putative anticodon binding site; other site 1087453005683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087453005684 motif 1; other site 1087453005685 dimer interface [polypeptide binding]; other site 1087453005686 active site 1087453005687 motif 2; other site 1087453005688 motif 3; other site 1087453005689 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1087453005690 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1087453005691 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1087453005692 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1087453005693 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1087453005694 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1087453005695 trimer interface [polypeptide binding]; other site 1087453005696 active site 1087453005697 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1087453005698 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1087453005699 NAD(P) binding site [chemical binding]; other site 1087453005700 catalytic residues [active] 1087453005701 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1087453005702 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1087453005703 VanW like protein; Region: VanW; pfam04294 1087453005704 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1087453005705 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1087453005706 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1087453005707 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1087453005708 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1087453005709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087453005710 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087453005711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453005712 S-adenosylmethionine binding site [chemical binding]; other site 1087453005713 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1087453005714 active site 1087453005715 substrate-binding site [chemical binding]; other site 1087453005716 metal-binding site [ion binding] 1087453005717 GTP binding site [chemical binding]; other site 1087453005718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087453005719 S-adenosylmethionine binding site [chemical binding]; other site 1087453005720 LabA_like proteins; Region: LabA_like; cd06167 1087453005721 putative metal binding site [ion binding]; other site 1087453005722 MMPL family; Region: MMPL; pfam03176 1087453005723 MMPL family; Region: MMPL; pfam03176 1087453005724 Predicted integral membrane protein [Function unknown]; Region: COG0392 1087453005725 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1087453005726 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1087453005727 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1087453005728 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1087453005729 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087453005730 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1087453005731 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1087453005732 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1087453005733 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1087453005734 active site 1087453005735 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1087453005736 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1087453005737 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1087453005738 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1087453005739 acyl-activating enzyme (AAE) consensus motif; other site 1087453005740 active site 1087453005741 Cutinase; Region: Cutinase; pfam01083 1087453005742 Putative esterase; Region: Esterase; pfam00756 1087453005743 S-formylglutathione hydrolase; Region: PLN02442 1087453005744 LGFP repeat; Region: LGFP; pfam08310 1087453005745 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1087453005746 LGFP repeat; Region: LGFP; pfam08310 1087453005747 LGFP repeat; Region: LGFP; pfam08310 1087453005748 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1087453005749 Predicted esterase [General function prediction only]; Region: COG0627 1087453005750 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1087453005751 UbiA prenyltransferase family; Region: UbiA; pfam01040 1087453005752 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1087453005753 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1087453005754 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1087453005755 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1087453005756 Repair protein; Region: Repair_PSII; pfam04536 1087453005757 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1087453005758 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1087453005759 active site 1087453005760 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1087453005761 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1087453005762 active site 1087453005763 catalytic site [active] 1087453005764 metal binding site [ion binding]; metal-binding site 1087453005765 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1087453005766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453005767 putative substrate translocation pore; other site 1087453005768 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1087453005769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1087453005770 UDP-galactopyranose mutase; Region: GLF; pfam03275 1087453005771 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087453005772 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087453005773 Walker A/P-loop; other site 1087453005774 ATP binding site [chemical binding]; other site 1087453005775 Q-loop/lid; other site 1087453005776 ABC transporter signature motif; other site 1087453005777 Walker B; other site 1087453005778 D-loop; other site 1087453005779 H-loop/switch region; other site 1087453005780 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087453005781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087453005782 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087453005783 putative PBP binding regions; other site 1087453005784 ABC-ATPase subunit interface; other site 1087453005785 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1087453005786 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1087453005787 putative binding site residues; other site 1087453005788 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1087453005789 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1087453005790 amidase catalytic site [active] 1087453005791 Zn binding residues [ion binding]; other site 1087453005792 substrate binding site [chemical binding]; other site 1087453005793 LGFP repeat; Region: LGFP; pfam08310 1087453005794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453005795 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1087453005796 active site 1087453005797 motif I; other site 1087453005798 motif II; other site 1087453005799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087453005800 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1087453005801 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1087453005802 putative acyl-acceptor binding pocket; other site 1087453005803 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1087453005804 seryl-tRNA synthetase; Provisional; Region: PRK05431 1087453005805 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1087453005806 dimer interface [polypeptide binding]; other site 1087453005807 active site 1087453005808 motif 1; other site 1087453005809 motif 2; other site 1087453005810 motif 3; other site 1087453005811 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1087453005812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087453005813 DNA-binding site [nucleotide binding]; DNA binding site 1087453005814 UTRA domain; Region: UTRA; pfam07702 1087453005815 Septum formation; Region: Septum_form; pfam13845 1087453005816 Septum formation; Region: Septum_form; pfam13845 1087453005817 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1087453005818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087453005819 catalytic core [active] 1087453005820 Prephenate dehydratase; Region: PDT; pfam00800 1087453005821 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1087453005822 putative L-Phe binding site [chemical binding]; other site 1087453005823 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1087453005824 Amidase; Region: Amidase; cl11426 1087453005825 CAAX protease self-immunity; Region: Abi; pfam02517 1087453005826 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1087453005827 Htaa; Region: HtaA; pfam04213 1087453005828 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1087453005829 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1087453005830 putative active site [active] 1087453005831 putative metal binding site [ion binding]; other site 1087453005832 catalytic site [active] 1087453005833 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1087453005834 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1087453005835 Nucleoside recognition; Region: Gate; pfam07670 1087453005836 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1087453005837 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1087453005838 active site 1087453005839 catalytic motif [active] 1087453005840 Zn binding site [ion binding]; other site 1087453005841 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1087453005842 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1087453005843 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1087453005844 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1087453005845 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1087453005846 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1087453005847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1087453005848 NAD binding site [chemical binding]; other site 1087453005849 dimer interface [polypeptide binding]; other site 1087453005850 substrate binding site [chemical binding]; other site 1087453005851 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1087453005852 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1087453005853 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1087453005854 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1087453005855 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1087453005856 Predicted flavoprotein [General function prediction only]; Region: COG0431 1087453005857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453005858 putative substrate translocation pore; other site 1087453005859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087453005860 Abi-like protein; Region: Abi_2; pfam07751 1087453005861 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1087453005862 homodimer interface [polypeptide binding]; other site 1087453005863 chemical substrate binding site [chemical binding]; other site 1087453005864 oligomer interface [polypeptide binding]; other site 1087453005865 metal binding site [ion binding]; metal-binding site 1087453005866 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1087453005867 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1087453005868 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1087453005869 Lsr2; Region: Lsr2; pfam11774 1087453005870 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087453005871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453005872 active site 1087453005873 phosphorylation site [posttranslational modification] 1087453005874 intermolecular recognition site; other site 1087453005875 dimerization interface [polypeptide binding]; other site 1087453005876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087453005877 DNA binding residues [nucleotide binding] 1087453005878 dimerization interface [polypeptide binding]; other site 1087453005879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087453005880 Histidine kinase; Region: HisKA_3; pfam07730 1087453005881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087453005882 ATP binding site [chemical binding]; other site 1087453005883 Mg2+ binding site [ion binding]; other site 1087453005884 G-X-G motif; other site 1087453005885 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1087453005886 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1087453005887 active site 1087453005888 catalytic site [active] 1087453005889 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1087453005890 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1087453005891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087453005892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087453005893 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1087453005894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087453005895 Ligand Binding Site [chemical binding]; other site 1087453005896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087453005897 Ligand Binding Site [chemical binding]; other site 1087453005898 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1087453005899 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1087453005900 active site 1087453005901 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1087453005902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087453005903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087453005904 Walker A/P-loop; other site 1087453005905 ATP binding site [chemical binding]; other site 1087453005906 Q-loop/lid; other site 1087453005907 ABC transporter signature motif; other site 1087453005908 Walker B; other site 1087453005909 D-loop; other site 1087453005910 H-loop/switch region; other site 1087453005911 Predicted transcriptional regulators [Transcription]; Region: COG1725 1087453005912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087453005913 DNA-binding site [nucleotide binding]; DNA binding site 1087453005914 LabA_like proteins; Region: LabA_like; cd06167 1087453005915 putative metal binding site [ion binding]; other site 1087453005916 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1087453005917 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1087453005918 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1087453005919 catalytic residues [active] 1087453005920 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1087453005921 metal-binding site [ion binding] 1087453005922 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1087453005923 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1087453005924 metal-binding site [ion binding] 1087453005925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1087453005926 benzoate transport; Region: 2A0115; TIGR00895 1087453005927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453005928 putative substrate translocation pore; other site 1087453005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087453005930 replicative DNA helicase; Provisional; Region: PRK05636 1087453005931 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1087453005932 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1087453005933 Walker A motif; other site 1087453005934 ATP binding site [chemical binding]; other site 1087453005935 Walker B motif; other site 1087453005936 DNA binding loops [nucleotide binding] 1087453005937 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1087453005938 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1087453005939 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1087453005940 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1087453005941 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1087453005942 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1087453005943 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1087453005944 dimer interface [polypeptide binding]; other site 1087453005945 ssDNA binding site [nucleotide binding]; other site 1087453005946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1087453005947 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1087453005948 Predicted integral membrane protein [Function unknown]; Region: COG5650 1087453005949 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1087453005950 Transglycosylase; Region: Transgly; pfam00912 1087453005951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1087453005952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1087453005953 MarR family; Region: MarR; pfam01047 1087453005954 MarR family; Region: MarR_2; cl17246 1087453005955 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087453005956 Ligand Binding Site [chemical binding]; other site 1087453005957 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087453005958 Ligand Binding Site [chemical binding]; other site 1087453005959 short chain dehydrogenase; Provisional; Region: PRK08219 1087453005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087453005961 NAD(P) binding site [chemical binding]; other site 1087453005962 active site 1087453005963 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1087453005964 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1087453005965 active site residue [active] 1087453005966 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1087453005967 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1087453005968 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1087453005969 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1087453005970 dimerization interface [polypeptide binding]; other site 1087453005971 DPS ferroxidase diiron center [ion binding]; other site 1087453005972 ion pore; other site 1087453005973 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1087453005974 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1087453005975 putative DNA binding site [nucleotide binding]; other site 1087453005976 catalytic residue [active] 1087453005977 putative H2TH interface [polypeptide binding]; other site 1087453005978 putative catalytic residues [active] 1087453005979 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1087453005980 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1087453005981 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1087453005982 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1087453005983 putative substrate binding site [chemical binding]; other site 1087453005984 putative ATP binding site [chemical binding]; other site 1087453005985 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1087453005986 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1087453005987 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1087453005988 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1087453005989 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1087453005990 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1087453005991 HIGH motif; other site 1087453005992 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1087453005993 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453005994 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087453005995 active site 1087453005996 KMSKS motif; other site 1087453005997 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1087453005998 tRNA binding surface [nucleotide binding]; other site 1087453005999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087453006000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087453006001 Walker A/P-loop; other site 1087453006002 ATP binding site [chemical binding]; other site 1087453006003 Q-loop/lid; other site 1087453006004 ABC transporter signature motif; other site 1087453006005 Walker B; other site 1087453006006 D-loop; other site 1087453006007 H-loop/switch region; other site 1087453006008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1087453006009 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1087453006010 FtsX-like permease family; Region: FtsX; pfam02687 1087453006011 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453006012 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453006013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087453006014 Histidine kinase; Region: HisKA_3; pfam07730 1087453006015 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087453006016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087453006017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087453006018 active site 1087453006019 phosphorylation site [posttranslational modification] 1087453006020 intermolecular recognition site; other site 1087453006021 dimerization interface [polypeptide binding]; other site 1087453006022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087453006023 DNA binding residues [nucleotide binding] 1087453006024 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453006025 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1087453006026 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453006027 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087453006028 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1087453006029 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1087453006030 active site 1087453006031 trimer interface [polypeptide binding]; other site 1087453006032 allosteric site; other site 1087453006033 active site lid [active] 1087453006034 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1087453006035 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1087453006036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1087453006037 active site 1087453006038 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1087453006039 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1087453006040 putative active site cavity [active] 1087453006041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087453006042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1087453006043 nucleotide binding site [chemical binding]; other site 1087453006044 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1087453006045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087453006046 DNA-binding site [nucleotide binding]; DNA binding site 1087453006047 FCD domain; Region: FCD; pfam07729 1087453006048 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087453006049 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1087453006050 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087453006051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453006052 dimer interface [polypeptide binding]; other site 1087453006053 conserved gate region; other site 1087453006054 putative PBP binding loops; other site 1087453006055 ABC-ATPase subunit interface; other site 1087453006056 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1087453006057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087453006058 dimer interface [polypeptide binding]; other site 1087453006059 conserved gate region; other site 1087453006060 putative PBP binding loops; other site 1087453006061 ABC-ATPase subunit interface; other site 1087453006062 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1087453006063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453006064 Walker A/P-loop; other site 1087453006065 ATP binding site [chemical binding]; other site 1087453006066 Q-loop/lid; other site 1087453006067 ABC transporter signature motif; other site 1087453006068 Walker B; other site 1087453006069 D-loop; other site 1087453006070 H-loop/switch region; other site 1087453006071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1087453006072 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1087453006073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087453006074 Walker A/P-loop; other site 1087453006075 ATP binding site [chemical binding]; other site 1087453006076 Q-loop/lid; other site 1087453006077 ABC transporter signature motif; other site 1087453006078 Walker B; other site 1087453006079 D-loop; other site 1087453006080 H-loop/switch region; other site 1087453006081 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087453006082 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1087453006083 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1087453006084 inhibitor site; inhibition site 1087453006085 active site 1087453006086 dimer interface [polypeptide binding]; other site 1087453006087 catalytic residue [active] 1087453006088 CAAX protease self-immunity; Region: Abi; cl00558 1087453006089 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1087453006090 active site 1087453006091 catalytic residues [active] 1087453006092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1087453006093 hypothetical protein; Provisional; Region: PRK13663 1087453006094 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1087453006095 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1087453006096 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1087453006097 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1087453006098 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1087453006099 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1087453006100 substrate binding pocket [chemical binding]; other site 1087453006101 substrate-Mg2+ binding site; other site 1087453006102 aspartate-rich region 1; other site 1087453006103 aspartate-rich region 2; other site 1087453006104 phytoene desaturase; Region: crtI_fam; TIGR02734 1087453006105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1087453006106 SdpI/YhfL protein family; Region: SdpI; pfam13630 1087453006107 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1087453006108 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1087453006109 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1087453006110 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1087453006111 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1087453006112 glutamine binding [chemical binding]; other site 1087453006113 catalytic triad [active] 1087453006114 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1087453006115 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1087453006116 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1087453006117 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1087453006118 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1087453006119 active site 1087453006120 ribulose/triose binding site [chemical binding]; other site 1087453006121 phosphate binding site [ion binding]; other site 1087453006122 substrate (anthranilate) binding pocket [chemical binding]; other site 1087453006123 product (indole) binding pocket [chemical binding]; other site 1087453006124 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1087453006125 active site 1087453006126 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1087453006127 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1087453006128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087453006129 catalytic residue [active] 1087453006130 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1087453006131 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1087453006132 substrate binding site [chemical binding]; other site 1087453006133 active site 1087453006134 catalytic residues [active] 1087453006135 heterodimer interface [polypeptide binding]; other site 1087453006136 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1087453006137 iron-sulfur cluster [ion binding]; other site 1087453006138 [2Fe-2S] cluster binding site [ion binding]; other site 1087453006139 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1087453006140 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1087453006141 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1087453006142 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1087453006143 hypothetical protein; Validated; Region: PRK00228 1087453006144 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1087453006145 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1087453006146 active site 1087453006147 NTP binding site [chemical binding]; other site 1087453006148 metal binding triad [ion binding]; metal-binding site 1087453006149 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1087453006150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087453006151 Zn2+ binding site [ion binding]; other site 1087453006152 Mg2+ binding site [ion binding]; other site 1087453006153 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1087453006154 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1087453006155 active site 1087453006156 Ap6A binding site [chemical binding]; other site 1087453006157 nudix motif; other site 1087453006158 metal binding site [ion binding]; metal-binding site 1087453006159 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1087453006160 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1087453006161 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1087453006162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087453006163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087453006164 DNA binding residues [nucleotide binding] 1087453006165 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1087453006166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087453006167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087453006168 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1087453006169 catalytic residues [active] 1087453006170 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1087453006171 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1087453006172 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1087453006173 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1087453006174 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1087453006175 active site 1087453006176 metal binding site [ion binding]; metal-binding site 1087453006177 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1087453006178 ParB-like nuclease domain; Region: ParBc; pfam02195 1087453006179 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1087453006180 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1087453006181 P-loop; other site 1087453006182 Magnesium ion binding site [ion binding]; other site 1087453006183 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1087453006184 Magnesium ion binding site [ion binding]; other site 1087453006185 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1087453006186 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1087453006187 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1087453006188 Haemolytic domain; Region: Haemolytic; pfam01809 1087453006189 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1087453006190 Ribosomal protein L34; Region: Ribosomal_L34; cl00370