-- dump date   	20140619_052432
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
681645000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
681645000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645000003	Walker A motif; other site
681645000004	ATP binding site [chemical binding]; other site
681645000005	Walker B motif; other site
681645000006	arginine finger; other site
681645000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
681645000008	DnaA box-binding interface [nucleotide binding]; other site
681645000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
681645000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
681645000011	putative DNA binding surface [nucleotide binding]; other site
681645000012	dimer interface [polypeptide binding]; other site
681645000013	beta-clamp/clamp loader binding surface; other site
681645000014	beta-clamp/translesion DNA polymerase binding surface; other site
681645000015	recombination protein F; Reviewed; Region: recF; PRK00064
681645000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
681645000017	Walker A/P-loop; other site
681645000018	ATP binding site [chemical binding]; other site
681645000019	Q-loop/lid; other site
681645000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645000021	ABC transporter signature motif; other site
681645000022	Walker B; other site
681645000023	D-loop; other site
681645000024	H-loop/switch region; other site
681645000025	hypothetical protein; Provisional; Region: PRK00111
681645000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
681645000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645000028	ATP binding site [chemical binding]; other site
681645000029	Mg2+ binding site [ion binding]; other site
681645000030	G-X-G motif; other site
681645000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
681645000032	anchoring element; other site
681645000033	dimer interface [polypeptide binding]; other site
681645000034	ATP binding site [chemical binding]; other site
681645000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
681645000036	active site
681645000037	putative metal-binding site [ion binding]; other site
681645000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
681645000039	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
681645000040	metal binding site [ion binding]; metal-binding site
681645000041	DNA gyrase subunit A; Validated; Region: PRK05560
681645000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
681645000043	CAP-like domain; other site
681645000044	active site
681645000045	primary dimer interface [polypeptide binding]; other site
681645000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
681645000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
681645000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
681645000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
681645000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
681645000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
681645000052	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
681645000053	YwiC-like protein; Region: YwiC; pfam14256
681645000054	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
681645000055	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
681645000056	putative ligand binding site [chemical binding]; other site
681645000057	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
681645000058	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
681645000059	TM-ABC transporter signature motif; other site
681645000060	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
681645000061	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
681645000062	Walker A/P-loop; other site
681645000063	ATP binding site [chemical binding]; other site
681645000064	Q-loop/lid; other site
681645000065	ABC transporter signature motif; other site
681645000066	Walker B; other site
681645000067	D-loop; other site
681645000068	H-loop/switch region; other site
681645000069	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
681645000070	active site
681645000071	Rhomboid family; Region: Rhomboid; pfam01694
681645000072	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
681645000073	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
681645000074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
681645000075	Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576
681645000076	putative active site [active]
681645000077	catalytic site [active]
681645000078	Mg binding site [ion binding]; other site
681645000079	catalytic loop [active]
681645000080	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645000081	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645000082	Walker A/P-loop; other site
681645000083	ATP binding site [chemical binding]; other site
681645000084	Q-loop/lid; other site
681645000085	ABC transporter signature motif; other site
681645000086	Walker B; other site
681645000087	D-loop; other site
681645000088	H-loop/switch region; other site
681645000089	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
681645000090	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645000091	ABC-ATPase subunit  interface; other site
681645000092	dimer interface [polypeptide binding]; other site
681645000093	putative PBP binding regions; other site
681645000094	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645000095	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645000096	ABC-ATPase subunit  interface; other site
681645000097	dimer interface [polypeptide binding]; other site
681645000098	putative PBP binding regions; other site
681645000099	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
681645000100	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
681645000101	siderophore binding site; other site
681645000102	putative septation inhibitor protein; Reviewed; Region: PRK00159
681645000103	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
681645000104	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
681645000105	active site
681645000106	ATP binding site [chemical binding]; other site
681645000107	substrate binding site [chemical binding]; other site
681645000108	activation loop (A-loop); other site
681645000109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
681645000110	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645000111	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645000112	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645000113	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645000114	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
681645000115	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
681645000116	active site
681645000117	ATP binding site [chemical binding]; other site
681645000118	substrate binding site [chemical binding]; other site
681645000119	activation loop (A-loop); other site
681645000120	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
681645000121	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
681645000122	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
681645000123	Protein phosphatase 2C; Region: PP2C; pfam00481
681645000124	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
681645000125	active site
681645000126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
681645000127	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
681645000128	phosphopeptide binding site; other site
681645000129	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
681645000130	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
681645000131	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
681645000132	phosphopeptide binding site; other site
681645000133	CAAX protease self-immunity; Region: Abi; pfam02517
681645000134	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
681645000135	Predicted transcriptional regulators [Transcription]; Region: COG1695
681645000136	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
681645000137	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
681645000138	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645000139	intersubunit interface [polypeptide binding]; other site
681645000140	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645000141	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645000142	Walker A/P-loop; other site
681645000143	ATP binding site [chemical binding]; other site
681645000144	Q-loop/lid; other site
681645000145	ABC transporter signature motif; other site
681645000146	Walker B; other site
681645000147	D-loop; other site
681645000148	H-loop/switch region; other site
681645000149	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645000150	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645000151	ABC-ATPase subunit  interface; other site
681645000152	dimer interface [polypeptide binding]; other site
681645000153	putative PBP binding regions; other site
681645000154	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
681645000155	MgtE intracellular N domain; Region: MgtE_N; smart00924
681645000156	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
681645000157	Divalent cation transporter; Region: MgtE; pfam01769
681645000158	trehalose synthase; Region: treS_nterm; TIGR02456
681645000159	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348
681645000160	active site
681645000161	catalytic site [active]
681645000162	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
681645000163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645000164	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645000165	putative substrate translocation pore; other site
681645000166	Anti-sigma-K factor rskA; Region: RskA; pfam10099
681645000167	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
681645000168	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645000169	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645000170	DNA binding residues [nucleotide binding]
681645000171	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
681645000172	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
681645000173	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
681645000174	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
681645000175	catalytic residues [active]
681645000176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
681645000177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645000178	dimer interface [polypeptide binding]; other site
681645000179	conserved gate region; other site
681645000180	putative PBP binding loops; other site
681645000181	ABC-ATPase subunit interface; other site
681645000182	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
681645000183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645000184	Walker A/P-loop; other site
681645000185	ATP binding site [chemical binding]; other site
681645000186	Q-loop/lid; other site
681645000187	ABC transporter signature motif; other site
681645000188	Walker B; other site
681645000189	D-loop; other site
681645000190	H-loop/switch region; other site
681645000191	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
681645000192	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
681645000193	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
681645000194	putative metal binding site [ion binding]; other site
681645000195	biotin synthase; Validated; Region: PRK06256
681645000196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645000197	FeS/SAM binding site; other site
681645000198	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
681645000199	MepB protein; Region: MepB; cl01985
681645000200	AMP nucleosidase; Provisional; Region: PRK08292
681645000201	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
681645000202	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
681645000203	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
681645000204	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
681645000205	active site
681645000206	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
681645000207	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
681645000208	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
681645000209	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
681645000210	Lipase (class 2); Region: Lipase_2; pfam01674
681645000211	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
681645000212	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
681645000213	trimer interface [polypeptide binding]; other site
681645000214	putative metal binding site [ion binding]; other site
681645000215	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
681645000216	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
681645000217	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
681645000218	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
681645000219	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
681645000220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645000221	Coenzyme A binding pocket [chemical binding]; other site
681645000222	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
681645000223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
681645000224	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
681645000225	MarR family; Region: MarR; pfam01047
681645000226	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
681645000227	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
681645000228	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
681645000229	hypothetical protein; Provisional; Region: PRK10621
681645000230	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
681645000231	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
681645000232	active site
681645000233	phosphorylation site [posttranslational modification]
681645000234	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
681645000235	active site
681645000236	P-loop; other site
681645000237	phosphorylation site [posttranslational modification]
681645000238	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
681645000239	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
681645000240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645000241	ATP binding site [chemical binding]; other site
681645000242	putative Mg++ binding site [ion binding]; other site
681645000243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645000244	nucleotide binding region [chemical binding]; other site
681645000245	ATP-binding site [chemical binding]; other site
681645000246	Helicase associated domain (HA2); Region: HA2; pfam04408
681645000247	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
681645000248	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
681645000249	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
681645000250	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
681645000251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645000252	NAD(P) binding site [chemical binding]; other site
681645000253	active site
681645000254	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
681645000255	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
681645000256	RNA binding surface [nucleotide binding]; other site
681645000257	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
681645000258	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
681645000259	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
681645000260	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
681645000261	DNA binding site [nucleotide binding]
681645000262	active site
681645000263	Domain of unknown function (DUF222); Region: DUF222; pfam02720
681645000264	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
681645000265	active site
681645000266	glycerol kinase; Provisional; Region: glpK; PRK00047
681645000267	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
681645000268	nucleotide binding site [chemical binding]; other site
681645000269	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
681645000270	amphipathic channel; other site
681645000271	Asn-Pro-Ala signature motifs; other site
681645000272	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
681645000273	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
681645000274	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
681645000275	active site
681645000276	Zn binding site [ion binding]; other site
681645000277	Protease prsW family; Region: PrsW-protease; pfam13367
681645000278	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
681645000279	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
681645000280	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
681645000281	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
681645000282	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
681645000283	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
681645000284	classical (c) SDRs; Region: SDR_c; cd05233
681645000285	NAD(P) binding site [chemical binding]; other site
681645000286	active site
681645000287	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
681645000288	FAD binding domain; Region: FAD_binding_4; pfam01565
681645000289	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
681645000290	Predicted membrane protein [Function unknown]; Region: COG2246
681645000291	GtrA-like protein; Region: GtrA; pfam04138
681645000292	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
681645000293	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
681645000294	active site
681645000295	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
681645000296	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
681645000297	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
681645000298	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
681645000299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645000300	ABC-ATPase subunit  interface; other site
681645000301	dimer interface [polypeptide binding]; other site
681645000302	putative PBP binding regions; other site
681645000303	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645000304	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
681645000305	intersubunit interface [polypeptide binding]; other site
681645000306	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
681645000307	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
681645000308	active site
681645000309	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
681645000310	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
681645000311	Walker A/P-loop; other site
681645000312	ATP binding site [chemical binding]; other site
681645000313	Q-loop/lid; other site
681645000314	ABC transporter signature motif; other site
681645000315	Walker B; other site
681645000316	D-loop; other site
681645000317	H-loop/switch region; other site
681645000318	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
681645000319	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
681645000320	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
681645000321	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
681645000322	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
681645000323	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
681645000324	NAD(P) binding site [chemical binding]; other site
681645000325	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
681645000326	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645000327	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645000328	homodimer interface [polypeptide binding]; other site
681645000329	catalytic residue [active]
681645000330	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
681645000331	transmembrane helices; other site
681645000332	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
681645000333	CAT RNA binding domain; Region: CAT_RBD; smart01061
681645000334	PRD domain; Region: PRD; pfam00874
681645000335	PRD domain; Region: PRD; pfam00874
681645000336	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
681645000337	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
681645000338	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
681645000339	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
681645000340	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
681645000341	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
681645000342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
681645000343	DNA-binding site [nucleotide binding]; DNA binding site
681645000344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645000345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645000346	homodimer interface [polypeptide binding]; other site
681645000347	catalytic residue [active]
681645000348	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
681645000349	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
681645000350	active site
681645000351	multimer interface [polypeptide binding]; other site
681645000352	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
681645000353	predicted active site [active]
681645000354	catalytic triad [active]
681645000355	prephenate dehydrogenase; Validated; Region: PRK06545
681645000356	prephenate dehydrogenase; Validated; Region: PRK08507
681645000357	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
681645000358	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
681645000359	nucleoside/Zn binding site; other site
681645000360	dimer interface [polypeptide binding]; other site
681645000361	catalytic motif [active]
681645000362	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
681645000363	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
681645000364	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
681645000365	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
681645000366	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
681645000367	active site
681645000368	KMSKS motif; other site
681645000369	fructuronate transporter; Provisional; Region: PRK10034; cl15264
681645000370	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
681645000371	Shikimate kinase; Region: SKI; pfam01202
681645000372	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
681645000373	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
681645000374	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
681645000375	putative NAD(P) binding site [chemical binding]; other site
681645000376	catalytic Zn binding site [ion binding]; other site
681645000377	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
681645000378	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
681645000379	NADP binding site [chemical binding]; other site
681645000380	homodimer interface [polypeptide binding]; other site
681645000381	active site
681645000382	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
681645000383	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645000384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645000385	homodimer interface [polypeptide binding]; other site
681645000386	catalytic residue [active]
681645000387	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
681645000388	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
681645000389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645000390	Walker A motif; other site
681645000391	ATP binding site [chemical binding]; other site
681645000392	Walker B motif; other site
681645000393	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
681645000394	arginine finger; other site
681645000395	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
681645000396	hypothetical protein; Validated; Region: PRK00153
681645000397	recombination protein RecR; Reviewed; Region: recR; PRK00076
681645000398	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
681645000399	RecR protein; Region: RecR; pfam02132
681645000400	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
681645000401	putative active site [active]
681645000402	putative metal-binding site [ion binding]; other site
681645000403	tetramer interface [polypeptide binding]; other site
681645000404	putative transporter; Provisional; Region: PRK09821
681645000405	GntP family permease; Region: GntP_permease; pfam02447
681645000406	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
681645000407	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
681645000408	Transcriptional regulators [Transcription]; Region: FadR; COG2186
681645000409	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
681645000410	DNA-binding site [nucleotide binding]; DNA binding site
681645000411	FCD domain; Region: FCD; pfam07729
681645000412	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
681645000413	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
681645000414	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
681645000415	catalytic triad [active]
681645000416	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
681645000417	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645000418	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
681645000419	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
681645000420	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
681645000421	active site
681645000422	catalytic site [active]
681645000423	substrate binding site [chemical binding]; other site
681645000424	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
681645000425	2-isopropylmalate synthase; Validated; Region: PRK03739
681645000426	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
681645000427	active site
681645000428	catalytic residues [active]
681645000429	metal binding site [ion binding]; metal-binding site
681645000430	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
681645000431	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
681645000432	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645000433	DNA binding residues [nucleotide binding]
681645000434	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
681645000435	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
681645000436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645000437	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645000438	putative substrate translocation pore; other site
681645000439	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
681645000440	intersubunit interface [polypeptide binding]; other site
681645000441	active site
681645000442	catalytic residue [active]
681645000443	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
681645000444	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
681645000445	active site
681645000446	substrate binding site [chemical binding]; other site
681645000447	metal binding site [ion binding]; metal-binding site
681645000448	TQXA domain; Region: TQXA_dom; TIGR03934
681645000449	Cna protein B-type domain; Region: Cna_B; pfam05738
681645000450	Cna protein B-type domain; Region: Cna_B; pfam05738
681645000451	Cna protein B-type domain; Region: Cna_B; pfam05738
681645000452	aspartate kinase; Reviewed; Region: PRK06635
681645000453	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
681645000454	putative nucleotide binding site [chemical binding]; other site
681645000455	putative catalytic residues [active]
681645000456	putative Mg ion binding site [ion binding]; other site
681645000457	putative aspartate binding site [chemical binding]; other site
681645000458	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
681645000459	putative allosteric regulatory site; other site
681645000460	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
681645000461	putative allosteric regulatory residue; other site
681645000462	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
681645000463	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
681645000464	RNA polymerase sigma factor; Provisional; Region: PRK12535
681645000465	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645000466	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
681645000467	DNA binding residues [nucleotide binding]
681645000468	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
681645000469	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
681645000470	heme binding pocket [chemical binding]; other site
681645000471	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
681645000472	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
681645000473	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
681645000474	Walker A/P-loop; other site
681645000475	ATP binding site [chemical binding]; other site
681645000476	Q-loop/lid; other site
681645000477	ABC transporter signature motif; other site
681645000478	Walker B; other site
681645000479	D-loop; other site
681645000480	H-loop/switch region; other site
681645000481	TOBE domain; Region: TOBE_2; pfam08402
681645000482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645000483	dimer interface [polypeptide binding]; other site
681645000484	conserved gate region; other site
681645000485	ABC-ATPase subunit interface; other site
681645000486	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
681645000487	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
681645000488	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
681645000489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645000490	putative substrate translocation pore; other site
681645000491	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
681645000492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645000493	active site
681645000494	phosphorylation site [posttranslational modification]
681645000495	intermolecular recognition site; other site
681645000496	dimerization interface [polypeptide binding]; other site
681645000497	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
681645000498	DNA binding site [nucleotide binding]
681645000499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
681645000500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
681645000501	dimer interface [polypeptide binding]; other site
681645000502	phosphorylation site [posttranslational modification]
681645000503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645000504	ATP binding site [chemical binding]; other site
681645000505	Mg2+ binding site [ion binding]; other site
681645000506	G-X-G motif; other site
681645000507	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
681645000508	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
681645000509	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
681645000510	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
681645000511	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
681645000512	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
681645000513	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
681645000514	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
681645000515	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
681645000516	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
681645000517	Predicted membrane protein [Function unknown]; Region: COG1511
681645000518	Predicted membrane protein [Function unknown]; Region: COG1511
681645000519	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
681645000520	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
681645000521	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
681645000522	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
681645000523	putative active site [active]
681645000524	putative metal binding site [ion binding]; other site
681645000525	Yqey-like protein; Region: YqeY; pfam09424
681645000526	Transglycosylase; Region: Transgly; pfam00912
681645000527	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
681645000528	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
681645000529	PASTA domain; Region: PASTA; pfam03793
681645000530	Transcription factor WhiB; Region: Whib; pfam02467
681645000531	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
681645000532	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
681645000533	homotrimer interaction site [polypeptide binding]; other site
681645000534	putative active site [active]
681645000535	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
681645000536	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
681645000537	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
681645000538	ligand binding site [chemical binding]; other site
681645000539	flexible hinge region; other site
681645000540	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
681645000541	putative switch regulator; other site
681645000542	non-specific DNA interactions [nucleotide binding]; other site
681645000543	DNA binding site [nucleotide binding]
681645000544	sequence specific DNA binding site [nucleotide binding]; other site
681645000545	putative cAMP binding site [chemical binding]; other site
681645000546	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
681645000547	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
681645000548	minor groove reading motif; other site
681645000549	helix-hairpin-helix signature motif; other site
681645000550	substrate binding pocket [chemical binding]; other site
681645000551	active site
681645000552	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
681645000553	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
681645000554	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
681645000555	catalytic residues [active]
681645000556	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
681645000557	putative active site [active]
681645000558	putative CoA binding site [chemical binding]; other site
681645000559	nudix motif; other site
681645000560	metal binding site [ion binding]; metal-binding site
681645000561	Colicin V production protein; Region: Colicin_V; pfam02674
681645000562	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
681645000563	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
681645000564	active site
681645000565	substrate binding sites [chemical binding]; other site
681645000566	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
681645000567	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
681645000568	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
681645000569	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645000570	motif II; other site
681645000571	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
681645000572	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
681645000573	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
681645000574	ATP binding site [chemical binding]; other site
681645000575	Walker A motif; other site
681645000576	hexamer interface [polypeptide binding]; other site
681645000577	Walker B motif; other site
681645000578	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
681645000579	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
681645000580	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
681645000581	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
681645000582	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645000583	ATP binding site [chemical binding]; other site
681645000584	putative Mg++ binding site [ion binding]; other site
681645000585	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645000586	nucleotide binding region [chemical binding]; other site
681645000587	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
681645000588	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
681645000589	DNA-binding site [nucleotide binding]; DNA binding site
681645000590	RNA-binding motif; other site
681645000591	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
681645000592	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
681645000593	active site
681645000594	interdomain interaction site; other site
681645000595	putative metal-binding site [ion binding]; other site
681645000596	nucleotide binding site [chemical binding]; other site
681645000597	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
681645000598	domain I; other site
681645000599	DNA binding groove [nucleotide binding]
681645000600	phosphate binding site [ion binding]; other site
681645000601	domain II; other site
681645000602	domain III; other site
681645000603	nucleotide binding site [chemical binding]; other site
681645000604	catalytic site [active]
681645000605	domain IV; other site
681645000606	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
681645000607	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
681645000608	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
681645000609	Predicted membrane protein [Function unknown]; Region: COG1297
681645000610	putative oligopeptide transporter, OPT family; Region: TIGR00733
681645000611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
681645000612	dimerization interface [polypeptide binding]; other site
681645000613	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
681645000614	cyclase homology domain; Region: CHD; cd07302
681645000615	nucleotidyl binding site; other site
681645000616	metal binding site [ion binding]; metal-binding site
681645000617	dimer interface [polypeptide binding]; other site
681645000618	DNA polymerase III subunit delta'; Validated; Region: PRK07940
681645000619	DNA polymerase III subunit delta'; Validated; Region: PRK08485
681645000620	acyl-CoA synthetase; Validated; Region: PRK07788
681645000621	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645000622	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645000623	acyl-activating enzyme (AAE) consensus motif; other site
681645000624	acyl-activating enzyme (AAE) consensus motif; other site
681645000625	AMP binding site [chemical binding]; other site
681645000626	active site
681645000627	CoA binding site [chemical binding]; other site
681645000628	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
681645000629	active site
681645000630	catalytic triad [active]
681645000631	oxyanion hole [active]
681645000632	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
681645000633	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
681645000634	substrate binding site; other site
681645000635	tetramer interface; other site
681645000636	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
681645000637	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
681645000638	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
681645000639	NADP binding site [chemical binding]; other site
681645000640	active site
681645000641	putative substrate binding site [chemical binding]; other site
681645000642	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
681645000643	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
681645000644	NAD binding site [chemical binding]; other site
681645000645	substrate binding site [chemical binding]; other site
681645000646	homodimer interface [polypeptide binding]; other site
681645000647	active site
681645000648	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
681645000649	Zn binding site [ion binding]; other site
681645000650	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
681645000651	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
681645000652	Putative esterase; Region: Esterase; pfam00756
681645000653	Peptidase family S64; Region: Peptidase_S64; pfam08192
681645000654	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
681645000655	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
681645000656	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
681645000657	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
681645000658	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
681645000659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
681645000660	non-specific DNA binding site [nucleotide binding]; other site
681645000661	salt bridge; other site
681645000662	sequence-specific DNA binding site [nucleotide binding]; other site
681645000663	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
681645000664	Domain of unknown function (DUF955); Region: DUF955; pfam06114
681645000665	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
681645000666	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
681645000667	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
681645000668	putative Iron-sulfur protein interface [polypeptide binding]; other site
681645000669	proximal heme binding site [chemical binding]; other site
681645000670	distal heme binding site [chemical binding]; other site
681645000671	putative dimer interface [polypeptide binding]; other site
681645000672	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
681645000673	L-aspartate oxidase; Provisional; Region: PRK06175
681645000674	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
681645000675	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
681645000676	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
681645000677	Predicted membrane protein [Function unknown]; Region: COG2733
681645000678	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
681645000679	Class I aldolases; Region: Aldolase_Class_I; cl17187
681645000680	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
681645000681	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
681645000682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645000683	FeS/SAM binding site; other site
681645000684	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
681645000685	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
681645000686	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
681645000687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
681645000688	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
681645000689	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
681645000690	FAD binding domain; Region: FAD_binding_4; pfam01565
681645000691	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
681645000692	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
681645000693	AMP-binding enzyme; Region: AMP-binding; pfam00501
681645000694	acyl-activating enzyme (AAE) consensus motif; other site
681645000695	putative AMP binding site [chemical binding]; other site
681645000696	putative active site [active]
681645000697	putative CoA binding site [chemical binding]; other site
681645000698	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
681645000699	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
681645000700	putative ADP-binding pocket [chemical binding]; other site
681645000701	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645000702	catalytic core [active]
681645000703	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645000704	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
681645000705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
681645000706	dimer interface [polypeptide binding]; other site
681645000707	phosphorylation site [posttranslational modification]
681645000708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645000709	ATP binding site [chemical binding]; other site
681645000710	Mg2+ binding site [ion binding]; other site
681645000711	G-X-G motif; other site
681645000712	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
681645000713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645000714	active site
681645000715	phosphorylation site [posttranslational modification]
681645000716	intermolecular recognition site; other site
681645000717	dimerization interface [polypeptide binding]; other site
681645000718	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
681645000719	DNA binding site [nucleotide binding]
681645000720	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
681645000721	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
681645000722	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
681645000723	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
681645000724	DNA binding domain, excisionase family; Region: excise; TIGR01764
681645000725	Thioredoxin; Region: Thioredoxin_4; cl17273
681645000726	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
681645000727	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
681645000728	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
681645000729	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
681645000730	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645000731	motif II; other site
681645000732	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
681645000733	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
681645000734	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
681645000735	tRNA; other site
681645000736	putative tRNA binding site [nucleotide binding]; other site
681645000737	putative NADP binding site [chemical binding]; other site
681645000738	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
681645000739	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
681645000740	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
681645000741	domain interfaces; other site
681645000742	active site
681645000743	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
681645000744	active site
681645000745	homodimer interface [polypeptide binding]; other site
681645000746	SAM binding site [chemical binding]; other site
681645000747	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
681645000748	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
681645000749	active site
681645000750	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
681645000751	dimer interface [polypeptide binding]; other site
681645000752	active site
681645000753	Schiff base residues; other site
681645000754	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
681645000755	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
681645000756	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
681645000757	substrate binding site [chemical binding]; other site
681645000758	active site
681645000759	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
681645000760	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
681645000761	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
681645000762	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
681645000763	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
681645000764	inhibitor-cofactor binding pocket; inhibition site
681645000765	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645000766	catalytic residue [active]
681645000767	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645000768	catalytic core [active]
681645000769	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
681645000770	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
681645000771	catalytic residues [active]
681645000772	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
681645000773	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
681645000774	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
681645000775	ResB-like family; Region: ResB; pfam05140
681645000776	Methyltransferase domain; Region: Methyltransf_31; pfam13847
681645000777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645000778	S-adenosylmethionine binding site [chemical binding]; other site
681645000779	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645000780	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645000781	Walker A/P-loop; other site
681645000782	ATP binding site [chemical binding]; other site
681645000783	Q-loop/lid; other site
681645000784	ABC transporter signature motif; other site
681645000785	Walker B; other site
681645000786	D-loop; other site
681645000787	H-loop/switch region; other site
681645000788	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
681645000789	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645000790	intersubunit interface [polypeptide binding]; other site
681645000791	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
681645000792	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645000793	ABC-ATPase subunit  interface; other site
681645000794	dimer interface [polypeptide binding]; other site
681645000795	putative PBP binding regions; other site
681645000796	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
681645000797	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
681645000798	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
681645000799	UbiA prenyltransferase family; Region: UbiA; pfam01040
681645000800	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
681645000801	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645000802	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645000803	acyl-activating enzyme (AAE) consensus motif; other site
681645000804	acyl-activating enzyme (AAE) consensus motif; other site
681645000805	AMP binding site [chemical binding]; other site
681645000806	active site
681645000807	CoA binding site [chemical binding]; other site
681645000808	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
681645000809	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
681645000810	substrate binding site [chemical binding]; other site
681645000811	oxyanion hole (OAH) forming residues; other site
681645000812	trimer interface [polypeptide binding]; other site
681645000813	O-succinylbenzoate synthase; Provisional; Region: PRK02901
681645000814	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
681645000815	active site
681645000816	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
681645000817	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
681645000818	dimer interface [polypeptide binding]; other site
681645000819	tetramer interface [polypeptide binding]; other site
681645000820	PYR/PP interface [polypeptide binding]; other site
681645000821	TPP binding site [chemical binding]; other site
681645000822	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
681645000823	TPP-binding site; other site
681645000824	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
681645000825	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
681645000826	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
681645000827	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
681645000828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645000829	S-adenosylmethionine binding site [chemical binding]; other site
681645000830	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
681645000831	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
681645000832	NAD(P) binding site [chemical binding]; other site
681645000833	LDH/MDH dimer interface [polypeptide binding]; other site
681645000834	substrate binding site [chemical binding]; other site
681645000835	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
681645000836	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
681645000837	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
681645000838	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
681645000839	substrate binding pocket [chemical binding]; other site
681645000840	chain length determination region; other site
681645000841	substrate-Mg2+ binding site; other site
681645000842	catalytic residues [active]
681645000843	aspartate-rich region 1; other site
681645000844	active site lid residues [active]
681645000845	aspartate-rich region 2; other site
681645000846	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
681645000847	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
681645000848	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
681645000849	putative homodimer interface [polypeptide binding]; other site
681645000850	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
681645000851	heterodimer interface [polypeptide binding]; other site
681645000852	homodimer interface [polypeptide binding]; other site
681645000853	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
681645000854	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
681645000855	23S rRNA interface [nucleotide binding]; other site
681645000856	L7/L12 interface [polypeptide binding]; other site
681645000857	putative thiostrepton binding site; other site
681645000858	L25 interface [polypeptide binding]; other site
681645000859	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
681645000860	mRNA/rRNA interface [nucleotide binding]; other site
681645000861	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
681645000862	trimer interface [polypeptide binding]; other site
681645000863	active site
681645000864	G bulge; other site
681645000865	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
681645000866	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
681645000867	FMN binding site [chemical binding]; other site
681645000868	active site
681645000869	substrate binding site [chemical binding]; other site
681645000870	catalytic residue [active]
681645000871	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
681645000872	23S rRNA interface [nucleotide binding]; other site
681645000873	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
681645000874	50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157
681645000875	L11 interface [polypeptide binding]; other site
681645000876	putative EF-Tu interaction site [polypeptide binding]; other site
681645000877	putative EF-G interaction site [polypeptide binding]; other site
681645000878	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645000879	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
681645000880	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645000881	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645000882	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645000883	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645000884	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
681645000885	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
681645000886	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
681645000887	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
681645000888	ABC-ATPase subunit  interface; other site
681645000889	dimer interface [polypeptide binding]; other site
681645000890	putative PBP binding regions; other site
681645000891	Ethylene insensitive 3; Region: EIN3; cl04813
681645000892	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
681645000893	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
681645000894	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
681645000895	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
681645000896	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
681645000897	RPB1 interaction site [polypeptide binding]; other site
681645000898	RPB10 interaction site [polypeptide binding]; other site
681645000899	RPB11 interaction site [polypeptide binding]; other site
681645000900	RPB3 interaction site [polypeptide binding]; other site
681645000901	RPB12 interaction site [polypeptide binding]; other site
681645000902	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
681645000903	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
681645000904	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
681645000905	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
681645000906	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
681645000907	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
681645000908	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
681645000909	G-loop; other site
681645000910	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
681645000911	DNA binding site [nucleotide binding]
681645000912	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
681645000913	Histidine kinase; Region: HisKA_3; pfam07730
681645000914	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
681645000915	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
681645000916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645000917	active site
681645000918	phosphorylation site [posttranslational modification]
681645000919	intermolecular recognition site; other site
681645000920	dimerization interface [polypeptide binding]; other site
681645000921	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
681645000922	DNA binding residues [nucleotide binding]
681645000923	dimerization interface [polypeptide binding]; other site
681645000924	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
681645000925	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
681645000926	TIGR03943 family protein; Region: TIGR03943
681645000927	Predicted permease; Region: DUF318; cl17795
681645000928	Radical SAM superfamily; Region: Radical_SAM; pfam04055
681645000929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645000930	FeS/SAM binding site; other site
681645000931	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
681645000932	Class III ribonucleotide reductase; Region: RNR_III; cd01675
681645000933	effector binding site; other site
681645000934	active site
681645000935	Zn binding site [ion binding]; other site
681645000936	glycine loop; other site
681645000937	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
681645000938	S17 interaction site [polypeptide binding]; other site
681645000939	S8 interaction site; other site
681645000940	16S rRNA interaction site [nucleotide binding]; other site
681645000941	streptomycin interaction site [chemical binding]; other site
681645000942	23S rRNA interaction site [nucleotide binding]; other site
681645000943	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
681645000944	30S ribosomal protein S7; Validated; Region: PRK05302
681645000945	elongation factor G; Reviewed; Region: PRK00007
681645000946	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
681645000947	G1 box; other site
681645000948	putative GEF interaction site [polypeptide binding]; other site
681645000949	GTP/Mg2+ binding site [chemical binding]; other site
681645000950	Switch I region; other site
681645000951	G2 box; other site
681645000952	G3 box; other site
681645000953	Switch II region; other site
681645000954	G4 box; other site
681645000955	G5 box; other site
681645000956	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
681645000957	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
681645000958	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
681645000959	elongation factor Tu; Reviewed; Region: PRK00049
681645000960	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
681645000961	G1 box; other site
681645000962	GEF interaction site [polypeptide binding]; other site
681645000963	GTP/Mg2+ binding site [chemical binding]; other site
681645000964	Switch I region; other site
681645000965	G2 box; other site
681645000966	G3 box; other site
681645000967	Switch II region; other site
681645000968	G4 box; other site
681645000969	G5 box; other site
681645000970	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
681645000971	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
681645000972	Antibiotic Binding Site [chemical binding]; other site
681645000973	Asp23 family; Region: Asp23; cl00574
681645000974	Asp23 family; Region: Asp23; cl00574
681645000975	Asp23 family; Region: Asp23; pfam03780
681645000976	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
681645000977	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
681645000978	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
681645000979	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
681645000980	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
681645000981	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
681645000982	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
681645000983	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
681645000984	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
681645000985	putative translocon binding site; other site
681645000986	protein-rRNA interface [nucleotide binding]; other site
681645000987	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
681645000988	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
681645000989	G-X-X-G motif; other site
681645000990	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
681645000991	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
681645000992	23S rRNA interface [nucleotide binding]; other site
681645000993	5S rRNA interface [nucleotide binding]; other site
681645000994	putative antibiotic binding site [chemical binding]; other site
681645000995	L25 interface [polypeptide binding]; other site
681645000996	L27 interface [polypeptide binding]; other site
681645000997	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
681645000998	putative translocon interaction site; other site
681645000999	23S rRNA interface [nucleotide binding]; other site
681645001000	signal recognition particle (SRP54) interaction site; other site
681645001001	L23 interface [polypeptide binding]; other site
681645001002	trigger factor interaction site; other site
681645001003	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
681645001004	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
681645001005	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
681645001006	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
681645001007	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645001008	Walker A/P-loop; other site
681645001009	ATP binding site [chemical binding]; other site
681645001010	Q-loop/lid; other site
681645001011	ABC transporter signature motif; other site
681645001012	Walker B; other site
681645001013	D-loop; other site
681645001014	H-loop/switch region; other site
681645001015	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645001016	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645001017	Walker A/P-loop; other site
681645001018	ATP binding site [chemical binding]; other site
681645001019	Q-loop/lid; other site
681645001020	ABC transporter signature motif; other site
681645001021	Walker B; other site
681645001022	D-loop; other site
681645001023	H-loop/switch region; other site
681645001024	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645001025	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
681645001026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001027	dimer interface [polypeptide binding]; other site
681645001028	conserved gate region; other site
681645001029	putative PBP binding loops; other site
681645001030	ABC-ATPase subunit interface; other site
681645001031	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
681645001032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001033	putative PBP binding loops; other site
681645001034	dimer interface [polypeptide binding]; other site
681645001035	ABC-ATPase subunit interface; other site
681645001036	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
681645001037	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
681645001038	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
681645001039	RNA binding site [nucleotide binding]; other site
681645001040	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
681645001041	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
681645001042	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
681645001043	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
681645001044	serine transporter; Region: stp; TIGR00814
681645001045	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
681645001046	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
681645001047	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
681645001048	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
681645001049	active site
681645001050	homotetramer interface [polypeptide binding]; other site
681645001051	homodimer interface [polypeptide binding]; other site
681645001052	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
681645001053	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
681645001054	active site
681645001055	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
681645001056	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
681645001057	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
681645001058	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
681645001059	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
681645001060	5S rRNA interface [nucleotide binding]; other site
681645001061	23S rRNA interface [nucleotide binding]; other site
681645001062	L5 interface [polypeptide binding]; other site
681645001063	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
681645001064	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
681645001065	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
681645001066	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
681645001067	23S rRNA binding site [nucleotide binding]; other site
681645001068	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
681645001069	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
681645001070	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
681645001071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001072	dimer interface [polypeptide binding]; other site
681645001073	conserved gate region; other site
681645001074	putative PBP binding loops; other site
681645001075	ABC-ATPase subunit interface; other site
681645001076	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
681645001077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001078	dimer interface [polypeptide binding]; other site
681645001079	conserved gate region; other site
681645001080	putative PBP binding loops; other site
681645001081	ABC-ATPase subunit interface; other site
681645001082	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
681645001083	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
681645001084	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
681645001085	Walker A/P-loop; other site
681645001086	ATP binding site [chemical binding]; other site
681645001087	Q-loop/lid; other site
681645001088	ABC transporter signature motif; other site
681645001089	Walker B; other site
681645001090	D-loop; other site
681645001091	H-loop/switch region; other site
681645001092	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
681645001093	SecY translocase; Region: SecY; pfam00344
681645001094	adenylate kinase; Reviewed; Region: adk; PRK00279
681645001095	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
681645001096	AMP-binding site [chemical binding]; other site
681645001097	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
681645001098	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
681645001099	catalytic site [active]
681645001100	BNR repeat-like domain; Region: BNR_2; pfam13088
681645001101	Asp-box motif; other site
681645001102	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
681645001103	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
681645001104	rRNA binding site [nucleotide binding]; other site
681645001105	predicted 30S ribosome binding site; other site
681645001106	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
681645001107	30S ribosomal protein S13; Region: bact_S13; TIGR03631
681645001108	30S ribosomal protein S11; Validated; Region: PRK05309
681645001109	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
681645001110	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
681645001111	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
681645001112	RNA binding surface [nucleotide binding]; other site
681645001113	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
681645001114	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
681645001115	alphaNTD - beta interaction site [polypeptide binding]; other site
681645001116	alphaNTD homodimer interface [polypeptide binding]; other site
681645001117	alphaNTD - beta' interaction site [polypeptide binding]; other site
681645001118	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
681645001119	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
681645001120	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
681645001121	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
681645001122	dimerization interface 3.5A [polypeptide binding]; other site
681645001123	active site
681645001124	Protein of unknown function (DUF690); Region: DUF690; cl04939
681645001125	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
681645001126	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
681645001127	active site
681645001128	catalytic residues [active]
681645001129	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
681645001130	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
681645001131	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
681645001132	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
681645001133	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
681645001134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645001135	Walker A/P-loop; other site
681645001136	ATP binding site [chemical binding]; other site
681645001137	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
681645001138	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
681645001139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
681645001140	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
681645001141	23S rRNA interface [nucleotide binding]; other site
681645001142	L3 interface [polypeptide binding]; other site
681645001143	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
681645001144	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
681645001145	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
681645001146	active site
681645001147	substrate binding site [chemical binding]; other site
681645001148	metal binding site [ion binding]; metal-binding site
681645001149	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
681645001150	alanine racemase; Reviewed; Region: alr; PRK00053
681645001151	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
681645001152	active site
681645001153	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
681645001154	dimer interface [polypeptide binding]; other site
681645001155	substrate binding site [chemical binding]; other site
681645001156	catalytic residues [active]
681645001157	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
681645001158	Predicted permease [General function prediction only]; Region: COG2985
681645001159	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
681645001160	TrkA-C domain; Region: TrkA_C; pfam02080
681645001161	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
681645001162	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
681645001163	Glycoprotease family; Region: Peptidase_M22; pfam00814
681645001164	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
681645001165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645001166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
681645001167	Coenzyme A binding pocket [chemical binding]; other site
681645001168	UGMP family protein; Validated; Region: PRK09604
681645001169	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
681645001170	oligomerisation interface [polypeptide binding]; other site
681645001171	mobile loop; other site
681645001172	roof hairpin; other site
681645001173	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
681645001174	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
681645001175	ring oligomerisation interface [polypeptide binding]; other site
681645001176	ATP/Mg binding site [chemical binding]; other site
681645001177	stacking interactions; other site
681645001178	hinge regions; other site
681645001179	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
681645001180	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645001181	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645001182	DNA binding residues [nucleotide binding]
681645001183	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
681645001184	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
681645001185	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
681645001186	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
681645001187	active site
681645001188	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
681645001189	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
681645001190	phosphate binding site [ion binding]; other site
681645001191	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
681645001192	GMP synthase; Reviewed; Region: guaA; PRK00074
681645001193	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
681645001194	AMP/PPi binding site [chemical binding]; other site
681645001195	candidate oxyanion hole; other site
681645001196	catalytic triad [active]
681645001197	potential glutamine specificity residues [chemical binding]; other site
681645001198	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
681645001199	ATP Binding subdomain [chemical binding]; other site
681645001200	Ligand Binding sites [chemical binding]; other site
681645001201	Dimerization subdomain; other site
681645001202	PspC domain; Region: PspC; cl00864
681645001203	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
681645001204	PspC domain; Region: PspC; pfam04024
681645001205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
681645001206	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
681645001207	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
681645001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645001209	active site
681645001210	phosphorylation site [posttranslational modification]
681645001211	intermolecular recognition site; other site
681645001212	dimerization interface [polypeptide binding]; other site
681645001213	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
681645001214	dimerization interface [polypeptide binding]; other site
681645001215	DNA binding residues [nucleotide binding]
681645001216	AMIN domain; Region: AMIN; pfam11741
681645001217	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
681645001218	putative dimer interface [polypeptide binding]; other site
681645001219	putative [2Fe-2S] cluster binding site [ion binding]; other site
681645001220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001221	dimer interface [polypeptide binding]; other site
681645001222	conserved gate region; other site
681645001223	ABC-ATPase subunit interface; other site
681645001224	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
681645001225	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
681645001226	Walker A/P-loop; other site
681645001227	ATP binding site [chemical binding]; other site
681645001228	Q-loop/lid; other site
681645001229	ABC transporter signature motif; other site
681645001230	Walker B; other site
681645001231	D-loop; other site
681645001232	H-loop/switch region; other site
681645001233	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
681645001234	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
681645001235	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
681645001236	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645001237	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
681645001238	intersubunit interface [polypeptide binding]; other site
681645001239	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
681645001240	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
681645001241	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
681645001242	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645001243	ABC-ATPase subunit  interface; other site
681645001244	dimer interface [polypeptide binding]; other site
681645001245	putative PBP binding regions; other site
681645001246	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
681645001247	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
681645001248	ABC-ATPase subunit  interface; other site
681645001249	dimer interface [polypeptide binding]; other site
681645001250	putative PBP binding regions; other site
681645001251	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
681645001252	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
681645001253	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
681645001254	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
681645001255	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
681645001256	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
681645001257	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
681645001258	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
681645001259	homodimer interface [polypeptide binding]; other site
681645001260	NADP binding site [chemical binding]; other site
681645001261	substrate binding site [chemical binding]; other site
681645001262	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
681645001263	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
681645001264	active site
681645001265	Htaa; Region: HtaA; pfam04213
681645001266	Htaa; Region: HtaA; pfam04213
681645001267	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
681645001268	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645001269	intersubunit interface [polypeptide binding]; other site
681645001270	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645001271	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645001272	ABC-ATPase subunit  interface; other site
681645001273	dimer interface [polypeptide binding]; other site
681645001274	putative PBP binding regions; other site
681645001275	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
681645001276	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645001277	Walker A/P-loop; other site
681645001278	ATP binding site [chemical binding]; other site
681645001279	Q-loop/lid; other site
681645001280	ABC transporter signature motif; other site
681645001281	Walker B; other site
681645001282	D-loop; other site
681645001283	H-loop/switch region; other site
681645001284	Htaa; Region: HtaA; pfam04213
681645001285	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
681645001286	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
681645001287	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
681645001288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645001289	putative substrate translocation pore; other site
681645001290	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
681645001291	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
681645001292	DNA binding residues [nucleotide binding]
681645001293	dimer interface [polypeptide binding]; other site
681645001294	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
681645001295	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
681645001296	putative catalytic site [active]
681645001297	putative metal binding site [ion binding]; other site
681645001298	putative phosphate binding site [ion binding]; other site
681645001299	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
681645001300	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
681645001301	active site
681645001302	HIGH motif; other site
681645001303	dimer interface [polypeptide binding]; other site
681645001304	KMSKS motif; other site
681645001305	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
681645001306	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
681645001307	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
681645001308	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
681645001309	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
681645001310	NlpC/P60 family; Region: NLPC_P60; pfam00877
681645001311	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645001312	active site
681645001313	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
681645001314	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
681645001315	non-specific DNA binding site [nucleotide binding]; other site
681645001316	salt bridge; other site
681645001317	sequence-specific DNA binding site [nucleotide binding]; other site
681645001318	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
681645001319	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
681645001320	active site
681645001321	substrate binding site [chemical binding]; other site
681645001322	metal binding site [ion binding]; metal-binding site
681645001323	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
681645001324	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
681645001325	metal binding site [ion binding]; metal-binding site
681645001326	putative dimer interface [polypeptide binding]; other site
681645001327	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
681645001328	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
681645001329	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
681645001330	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
681645001331	pyruvate carboxylase; Reviewed; Region: PRK12999
681645001332	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
681645001333	ATP-grasp domain; Region: ATP-grasp_4; cl17255
681645001334	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
681645001335	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
681645001336	active site
681645001337	catalytic residues [active]
681645001338	metal binding site [ion binding]; metal-binding site
681645001339	homodimer binding site [polypeptide binding]; other site
681645001340	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
681645001341	carboxyltransferase (CT) interaction site; other site
681645001342	biotinylation site [posttranslational modification]; other site
681645001343	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645001344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645001345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645001346	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
681645001347	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
681645001348	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
681645001349	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
681645001350	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
681645001351	carboxyltransferase (CT) interaction site; other site
681645001352	biotinylation site [posttranslational modification]; other site
681645001353	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
681645001354	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
681645001355	active site residue [active]
681645001356	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
681645001357	active site residue [active]
681645001358	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
681645001359	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
681645001360	Maf-like protein; Region: Maf; pfam02545
681645001361	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
681645001362	active site
681645001363	dimer interface [polypeptide binding]; other site
681645001364	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
681645001365	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
681645001366	substrate binding site [chemical binding]; other site
681645001367	ATP binding site [chemical binding]; other site
681645001368	Transcriptional regulators [Transcription]; Region: PurR; COG1609
681645001369	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
681645001370	DNA binding site [nucleotide binding]
681645001371	domain linker motif; other site
681645001372	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
681645001373	putative ligand binding site [chemical binding]; other site
681645001374	dimerization interface [polypeptide binding]; other site
681645001375	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
681645001376	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
681645001377	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
681645001378	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
681645001379	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
681645001380	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
681645001381	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
681645001382	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
681645001383	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
681645001384	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
681645001385	ATP-grasp domain; Region: ATP-grasp; pfam02222
681645001386	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
681645001387	Uncharacterized conserved protein [Function unknown]; Region: COG1434
681645001388	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
681645001389	putative active site [active]
681645001390	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
681645001391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001392	dimer interface [polypeptide binding]; other site
681645001393	conserved gate region; other site
681645001394	putative PBP binding loops; other site
681645001395	ABC-ATPase subunit interface; other site
681645001396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001397	dimer interface [polypeptide binding]; other site
681645001398	conserved gate region; other site
681645001399	putative PBP binding loops; other site
681645001400	ABC-ATPase subunit interface; other site
681645001401	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
681645001402	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
681645001403	TIGR03089 family protein; Region: TIGR03089
681645001404	Transcriptional regulator [Transcription]; Region: LytR; COG1316
681645001405	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
681645001406	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
681645001407	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
681645001408	Probable Catalytic site; other site
681645001409	metal-binding site
681645001410	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
681645001411	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
681645001412	active site
681645001413	Substrate binding site; other site
681645001414	Mg++ binding site; other site
681645001415	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
681645001416	putative trimer interface [polypeptide binding]; other site
681645001417	putative CoA binding site [chemical binding]; other site
681645001418	Transcription factor WhiB; Region: Whib; pfam02467
681645001419	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
681645001420	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
681645001421	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
681645001422	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
681645001423	active site
681645001424	substrate binding site [chemical binding]; other site
681645001425	metal binding site [ion binding]; metal-binding site
681645001426	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
681645001427	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
681645001428	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
681645001429	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
681645001430	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
681645001431	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
681645001432	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
681645001433	homotetramer interface [polypeptide binding]; other site
681645001434	ligand binding site [chemical binding]; other site
681645001435	catalytic site [active]
681645001436	NAD binding site [chemical binding]; other site
681645001437	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
681645001438	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
681645001439	TMP-binding site; other site
681645001440	ATP-binding site [chemical binding]; other site
681645001441	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
681645001442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645001443	active site
681645001444	phosphorylation site [posttranslational modification]
681645001445	intermolecular recognition site; other site
681645001446	dimerization interface [polypeptide binding]; other site
681645001447	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
681645001448	DNA binding site [nucleotide binding]
681645001449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
681645001450	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
681645001451	dimerization interface [polypeptide binding]; other site
681645001452	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
681645001453	dimer interface [polypeptide binding]; other site
681645001454	phosphorylation site [posttranslational modification]
681645001455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645001456	ATP binding site [chemical binding]; other site
681645001457	Mg2+ binding site [ion binding]; other site
681645001458	G-X-G motif; other site
681645001459	lipoprotein LpqB; Provisional; Region: PRK13616
681645001460	Sporulation and spore germination; Region: Germane; pfam10646
681645001461	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
681645001462	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645001463	active site
681645001464	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
681645001465	30S subunit binding site; other site
681645001466	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
681645001467	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
681645001468	ATP binding site [chemical binding]; other site
681645001469	putative Mg++ binding site [ion binding]; other site
681645001470	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
681645001471	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
681645001472	nucleotide binding region [chemical binding]; other site
681645001473	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
681645001474	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
681645001475	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
681645001476	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
681645001477	FAD binding pocket [chemical binding]; other site
681645001478	FAD binding motif [chemical binding]; other site
681645001479	phosphate binding motif [ion binding]; other site
681645001480	beta-alpha-beta structure motif; other site
681645001481	NAD binding pocket [chemical binding]; other site
681645001482	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
681645001483	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
681645001484	catalytic loop [active]
681645001485	iron binding site [ion binding]; other site
681645001486	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
681645001487	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
681645001488	putative di-iron ligands [ion binding]; other site
681645001489	Predicted GTPases [General function prediction only]; Region: COG1162
681645001490	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
681645001491	GTPase/Zn-binding domain interface [polypeptide binding]; other site
681645001492	GTP/Mg2+ binding site [chemical binding]; other site
681645001493	G4 box; other site
681645001494	G5 box; other site
681645001495	G1 box; other site
681645001496	Switch I region; other site
681645001497	G2 box; other site
681645001498	G3 box; other site
681645001499	Switch II region; other site
681645001500	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
681645001501	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
681645001502	hinge; other site
681645001503	active site
681645001504	Uncharacterized conserved protein [Function unknown]; Region: COG2135
681645001505	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
681645001506	putative deacylase active site [active]
681645001507	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
681645001508	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645001509	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645001510	DNA binding residues [nucleotide binding]
681645001511	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
681645001512	Transcription factor WhiB; Region: Whib; pfam02467
681645001513	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
681645001514	active site
681645001515	catalytic triad [active]
681645001516	oxyanion hole [active]
681645001517	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
681645001518	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
681645001519	DEAD-like helicases superfamily; Region: DEXDc; smart00487
681645001520	ATP binding site [chemical binding]; other site
681645001521	Mg++ binding site [ion binding]; other site
681645001522	motif III; other site
681645001523	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645001524	nucleotide binding region [chemical binding]; other site
681645001525	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
681645001526	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
681645001527	TIGR02569 family protein; Region: TIGR02569_actnb
681645001528	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
681645001529	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
681645001530	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
681645001531	Part of AAA domain; Region: AAA_19; pfam13245
681645001532	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
681645001533	Ion channel; Region: Ion_trans_2; pfam07885
681645001534	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
681645001535	TrkA-N domain; Region: TrkA_N; pfam02254
681645001536	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
681645001537	putative NADH binding site [chemical binding]; other site
681645001538	putative active site [active]
681645001539	nudix motif; other site
681645001540	putative metal binding site [ion binding]; other site
681645001541	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
681645001542	Part of AAA domain; Region: AAA_19; pfam13245
681645001543	Family description; Region: UvrD_C_2; pfam13538
681645001544	HRDC domain; Region: HRDC; pfam00570
681645001545	Protein of unknown function DUF45; Region: DUF45; cl00636
681645001546	putative hydrolase; Region: TIGR03624
681645001547	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
681645001548	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
681645001549	hypothetical protein; Validated; Region: PRK00068
681645001550	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
681645001551	Abi-like protein; Region: Abi_2; pfam07751
681645001552	Predicted helicase [General function prediction only]; Region: COG4889
681645001553	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
681645001554	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645001555	ATP binding site [chemical binding]; other site
681645001556	putative Mg++ binding site [ion binding]; other site
681645001557	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645001558	ATP-binding site [chemical binding]; other site
681645001559	Methyltransferase domain; Region: Methyltransf_26; pfam13659
681645001560	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
681645001561	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
681645001562	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
681645001563	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
681645001564	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
681645001565	Predicted membrane protein [Function unknown]; Region: COG2311
681645001566	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
681645001567	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645001568	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
681645001569	acyl-activating enzyme (AAE) consensus motif; other site
681645001570	AMP binding site [chemical binding]; other site
681645001571	active site
681645001572	CoA binding site [chemical binding]; other site
681645001573	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
681645001574	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
681645001575	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
681645001576	putative trimer interface [polypeptide binding]; other site
681645001577	putative CoA binding site [chemical binding]; other site
681645001578	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
681645001579	putative trimer interface [polypeptide binding]; other site
681645001580	putative CoA binding site [chemical binding]; other site
681645001581	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
681645001582	oxaloacetate decarboxylase; Provisional; Region: PRK12330
681645001583	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
681645001584	active site
681645001585	catalytic residues [active]
681645001586	metal binding site [ion binding]; metal-binding site
681645001587	homodimer binding site [polypeptide binding]; other site
681645001588	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
681645001589	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
681645001590	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
681645001591	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
681645001592	carboxyltransferase (CT) interaction site; other site
681645001593	biotinylation site [posttranslational modification]; other site
681645001594	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
681645001595	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
681645001596	active site
681645001597	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
681645001598	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
681645001599	active site
681645001600	peptide chain release factor 2; Validated; Region: prfB; PRK00578
681645001601	This domain is found in peptide chain release factors; Region: PCRF; smart00937
681645001602	RF-1 domain; Region: RF-1; pfam00472
681645001603	topology modulation protein; Provisional; Region: PRK07261
681645001604	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
681645001605	active site
681645001606	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
681645001607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645001608	Walker A/P-loop; other site
681645001609	ATP binding site [chemical binding]; other site
681645001610	Q-loop/lid; other site
681645001611	ABC transporter signature motif; other site
681645001612	Walker B; other site
681645001613	D-loop; other site
681645001614	H-loop/switch region; other site
681645001615	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
681645001616	FtsX-like permease family; Region: FtsX; pfam02687
681645001617	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
681645001618	SmpB-tmRNA interface; other site
681645001619	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
681645001620	active site clefts [active]
681645001621	zinc binding site [ion binding]; other site
681645001622	dimer interface [polypeptide binding]; other site
681645001623	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
681645001624	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645001625	intersubunit interface [polypeptide binding]; other site
681645001626	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645001627	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645001628	ABC-ATPase subunit  interface; other site
681645001629	dimer interface [polypeptide binding]; other site
681645001630	putative PBP binding regions; other site
681645001631	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645001632	ABC-ATPase subunit  interface; other site
681645001633	dimer interface [polypeptide binding]; other site
681645001634	putative PBP binding regions; other site
681645001635	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
681645001636	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645001637	Walker A/P-loop; other site
681645001638	ATP binding site [chemical binding]; other site
681645001639	Q-loop/lid; other site
681645001640	ABC transporter signature motif; other site
681645001641	Walker B; other site
681645001642	D-loop; other site
681645001643	H-loop/switch region; other site
681645001644	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
681645001645	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
681645001646	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
681645001647	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645001648	ATP binding site [chemical binding]; other site
681645001649	putative Mg++ binding site [ion binding]; other site
681645001650	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645001651	nucleotide binding region [chemical binding]; other site
681645001652	ATP-binding site [chemical binding]; other site
681645001653	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
681645001654	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
681645001655	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
681645001656	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
681645001657	DNA-binding site [nucleotide binding]; DNA binding site
681645001658	RNA-binding motif; other site
681645001659	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
681645001660	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
681645001661	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
681645001662	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
681645001663	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
681645001664	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
681645001665	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
681645001666	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
681645001667	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
681645001668	catalytic residue [active]
681645001669	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
681645001670	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
681645001671	dimer interface [polypeptide binding]; other site
681645001672	active site
681645001673	citrylCoA binding site [chemical binding]; other site
681645001674	NADH binding [chemical binding]; other site
681645001675	cationic pore residues; other site
681645001676	oxalacetate/citrate binding site [chemical binding]; other site
681645001677	coenzyme A binding site [chemical binding]; other site
681645001678	catalytic triad [active]
681645001679	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
681645001680	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
681645001681	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
681645001682	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
681645001683	E-class dimer interface [polypeptide binding]; other site
681645001684	P-class dimer interface [polypeptide binding]; other site
681645001685	active site
681645001686	Cu2+ binding site [ion binding]; other site
681645001687	Zn2+ binding site [ion binding]; other site
681645001688	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
681645001689	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
681645001690	active site
681645001691	catalytic tetrad [active]
681645001692	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
681645001693	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
681645001694	substrate binding site [chemical binding]; other site
681645001695	oxyanion hole (OAH) forming residues; other site
681645001696	trimer interface [polypeptide binding]; other site
681645001697	Protein of unknown function, DUF485; Region: DUF485; pfam04341
681645001698	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
681645001699	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
681645001700	Na binding site [ion binding]; other site
681645001701	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
681645001702	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
681645001703	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
681645001704	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
681645001705	multidrug efflux protein NorA; Provisional; Region: PRK00187
681645001706	cation binding site [ion binding]; other site
681645001707	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
681645001708	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
681645001709	dimer interface [polypeptide binding]; other site
681645001710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645001711	catalytic residue [active]
681645001712	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
681645001713	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
681645001714	catalytic residue [active]
681645001715	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
681645001716	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
681645001717	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
681645001718	substrate binding pocket [chemical binding]; other site
681645001719	active site
681645001720	iron coordination sites [ion binding]; other site
681645001721	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
681645001722	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
681645001723	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
681645001724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001725	dimer interface [polypeptide binding]; other site
681645001726	conserved gate region; other site
681645001727	putative PBP binding loops; other site
681645001728	ABC-ATPase subunit interface; other site
681645001729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
681645001730	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
681645001731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645001732	Walker A/P-loop; other site
681645001733	ATP binding site [chemical binding]; other site
681645001734	Q-loop/lid; other site
681645001735	ABC transporter signature motif; other site
681645001736	Walker B; other site
681645001737	D-loop; other site
681645001738	H-loop/switch region; other site
681645001739	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645001740	Walker A/P-loop; other site
681645001741	ATP binding site [chemical binding]; other site
681645001742	Q-loop/lid; other site
681645001743	ABC transporter signature motif; other site
681645001744	Walker B; other site
681645001745	D-loop; other site
681645001746	H-loop/switch region; other site
681645001747	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
681645001748	active site
681645001749	SAM binding site [chemical binding]; other site
681645001750	homodimer interface [polypeptide binding]; other site
681645001751	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
681645001752	catalytic residues [active]
681645001753	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
681645001754	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
681645001755	folate binding site [chemical binding]; other site
681645001756	NADP+ binding site [chemical binding]; other site
681645001757	thymidylate synthase; Reviewed; Region: thyA; PRK01827
681645001758	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
681645001759	dimerization interface [polypeptide binding]; other site
681645001760	active site
681645001761	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
681645001762	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
681645001763	active site
681645001764	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645001765	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
681645001766	ATP binding site [chemical binding]; other site
681645001767	putative Mg++ binding site [ion binding]; other site
681645001768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645001769	nucleotide binding region [chemical binding]; other site
681645001770	ATP-binding site [chemical binding]; other site
681645001771	DEAD/H associated; Region: DEAD_assoc; pfam08494
681645001772	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
681645001773	active site
681645001774	SUMO-1 interface [polypeptide binding]; other site
681645001775	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
681645001776	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
681645001777	putative DNA binding site [nucleotide binding]; other site
681645001778	putative catalytic residues [active]
681645001779	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
681645001780	hypothetical protein; Provisional; Region: PRK11770
681645001781	Domain of unknown function (DUF307); Region: DUF307; pfam03733
681645001782	Domain of unknown function (DUF307); Region: DUF307; pfam03733
681645001783	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
681645001784	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
681645001785	active site
681645001786	dimer interface [polypeptide binding]; other site
681645001787	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
681645001788	dimer interface [polypeptide binding]; other site
681645001789	active site
681645001790	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
681645001791	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
681645001792	tetramerization interface [polypeptide binding]; other site
681645001793	NAD(P) binding site [chemical binding]; other site
681645001794	catalytic residues [active]
681645001795	hypothetical protein; Provisional; Region: PRK07857
681645001796	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
681645001797	Part of AAA domain; Region: AAA_19; pfam13245
681645001798	Family description; Region: UvrD_C_2; pfam13538
681645001799	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
681645001800	Peptidase family M23; Region: Peptidase_M23; pfam01551
681645001801	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
681645001802	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
681645001803	active site
681645001804	substrate binding site [chemical binding]; other site
681645001805	cosubstrate binding site; other site
681645001806	catalytic site [active]
681645001807	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
681645001808	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
681645001809	purine monophosphate binding site [chemical binding]; other site
681645001810	dimer interface [polypeptide binding]; other site
681645001811	putative catalytic residues [active]
681645001812	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
681645001813	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
681645001814	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
681645001815	Walker A/P-loop; other site
681645001816	ATP binding site [chemical binding]; other site
681645001817	Q-loop/lid; other site
681645001818	ABC transporter signature motif; other site
681645001819	Walker B; other site
681645001820	D-loop; other site
681645001821	H-loop/switch region; other site
681645001822	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
681645001823	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
681645001824	substrate binding pocket [chemical binding]; other site
681645001825	membrane-bound complex binding site; other site
681645001826	hinge residues; other site
681645001827	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
681645001828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001829	dimer interface [polypeptide binding]; other site
681645001830	conserved gate region; other site
681645001831	putative PBP binding loops; other site
681645001832	ABC-ATPase subunit interface; other site
681645001833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645001834	dimer interface [polypeptide binding]; other site
681645001835	conserved gate region; other site
681645001836	putative PBP binding loops; other site
681645001837	ABC-ATPase subunit interface; other site
681645001838	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
681645001839	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645001840	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645001841	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
681645001842	30S ribosomal protein S18; Provisional; Region: PRK13401
681645001843	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
681645001844	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
681645001845	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
681645001846	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
681645001847	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
681645001848	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
681645001849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645001850	active site
681645001851	phosphorylation site [posttranslational modification]
681645001852	intermolecular recognition site; other site
681645001853	dimerization interface [polypeptide binding]; other site
681645001854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
681645001855	DNA binding site [nucleotide binding]
681645001856	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
681645001857	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
681645001858	dimerization interface [polypeptide binding]; other site
681645001859	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
681645001860	dimer interface [polypeptide binding]; other site
681645001861	phosphorylation site [posttranslational modification]
681645001862	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645001863	ATP binding site [chemical binding]; other site
681645001864	Mg2+ binding site [ion binding]; other site
681645001865	G-X-G motif; other site
681645001866	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
681645001867	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
681645001868	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
681645001869	protein binding site [polypeptide binding]; other site
681645001870	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
681645001871	MPT binding site; other site
681645001872	trimer interface [polypeptide binding]; other site
681645001873	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
681645001874	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
681645001875	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
681645001876	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
681645001877	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
681645001878	active site
681645001879	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
681645001880	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
681645001881	dimer interface [polypeptide binding]; other site
681645001882	putative functional site; other site
681645001883	putative MPT binding site; other site
681645001884	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
681645001885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645001886	Coenzyme A binding pocket [chemical binding]; other site
681645001887	Predicted membrane protein [Function unknown]; Region: COG2259
681645001888	Predicted integral membrane protein [Function unknown]; Region: COG5660
681645001889	Putative zinc-finger; Region: zf-HC2; pfam13490
681645001890	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
681645001891	BCCT family transporter; Region: BCCT; pfam02028
681645001892	Uncharacterized membrane protein [Function unknown]; Region: COG3949
681645001893	Predicted methyltransferases [General function prediction only]; Region: COG0313
681645001894	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
681645001895	putative SAM binding site [chemical binding]; other site
681645001896	putative homodimer interface [polypeptide binding]; other site
681645001897	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
681645001898	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
681645001899	active site
681645001900	HIGH motif; other site
681645001901	KMSKS motif; other site
681645001902	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
681645001903	tRNA binding surface [nucleotide binding]; other site
681645001904	anticodon binding site; other site
681645001905	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
681645001906	active site
681645001907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
681645001908	Domain of unknown function (DUF348); Region: DUF348; pfam03990
681645001909	Domain of unknown function (DUF348); Region: DUF348; pfam03990
681645001910	G5 domain; Region: G5; pfam07501
681645001911	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
681645001912	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
681645001913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645001914	S-adenosylmethionine binding site [chemical binding]; other site
681645001915	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
681645001916	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
681645001917	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645001918	ABC transporter; Region: ABC_tran_2; pfam12848
681645001919	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645001920	Uncharacterized conserved protein [Function unknown]; Region: COG1359
681645001921	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
681645001922	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
681645001923	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
681645001924	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
681645001925	substrate binding site [chemical binding]; other site
681645001926	oxyanion hole (OAH) forming residues; other site
681645001927	trimer interface [polypeptide binding]; other site
681645001928	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
681645001929	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
681645001930	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
681645001931	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
681645001932	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
681645001933	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
681645001934	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
681645001935	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
681645001936	G1 box; other site
681645001937	putative GEF interaction site [polypeptide binding]; other site
681645001938	GTP/Mg2+ binding site [chemical binding]; other site
681645001939	Switch I region; other site
681645001940	G2 box; other site
681645001941	G3 box; other site
681645001942	Switch II region; other site
681645001943	G4 box; other site
681645001944	G5 box; other site
681645001945	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
681645001946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645001947	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
681645001948	NAD(P) binding site [chemical binding]; other site
681645001949	active site
681645001950	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
681645001951	putative active site [active]
681645001952	catalytic residue [active]
681645001953	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
681645001954	FMN binding site [chemical binding]; other site
681645001955	substrate binding site [chemical binding]; other site
681645001956	putative catalytic residue [active]
681645001957	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
681645001958	putative active site [active]
681645001959	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
681645001960	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
681645001961	5S rRNA interface [nucleotide binding]; other site
681645001962	CTC domain interface [polypeptide binding]; other site
681645001963	L16 interface [polypeptide binding]; other site
681645001964	pullulanase, type I; Region: pulA_typeI; TIGR02104
681645001965	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
681645001966	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
681645001967	Ca binding site [ion binding]; other site
681645001968	active site
681645001969	catalytic site [active]
681645001970	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
681645001971	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
681645001972	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645001973	active site
681645001974	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
681645001975	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
681645001976	Substrate binding site; other site
681645001977	Mg++ binding site; other site
681645001978	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
681645001979	active site
681645001980	substrate binding site [chemical binding]; other site
681645001981	CoA binding site [chemical binding]; other site
681645001982	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
681645001983	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
681645001984	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
681645001985	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
681645001986	gating phenylalanine in ion channel; other site
681645001987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645001988	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645001989	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
681645001990	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
681645001991	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645001992	ATP binding site [chemical binding]; other site
681645001993	putative Mg++ binding site [ion binding]; other site
681645001994	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645001995	nucleotide binding region [chemical binding]; other site
681645001996	ATP-binding site [chemical binding]; other site
681645001997	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
681645001998	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
681645001999	Spore germination protein; Region: Spore_permease; cl17796
681645002000	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
681645002001	homodimer interface [polypeptide binding]; other site
681645002002	metal binding site [ion binding]; metal-binding site
681645002003	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
681645002004	N-acetyl-D-glucosamine binding site [chemical binding]; other site
681645002005	enolase; Provisional; Region: eno; PRK00077
681645002006	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
681645002007	dimer interface [polypeptide binding]; other site
681645002008	metal binding site [ion binding]; metal-binding site
681645002009	substrate binding pocket [chemical binding]; other site
681645002010	Septum formation initiator; Region: DivIC; pfam04977
681645002011	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
681645002012	Uncharacterized conserved protein [Function unknown]; Region: COG1507
681645002013	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
681645002014	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
681645002015	Helix-turn-helix domain; Region: HTH_18; pfam12833
681645002016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
681645002017	Bax inhibitor 1 like; Region: BaxI_1; cl17691
681645002018	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
681645002019	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
681645002020	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
681645002021	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
681645002022	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
681645002023	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
681645002024	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
681645002025	catalytic residue [active]
681645002026	putative FPP diphosphate  binding site; other site
681645002027	putative FPP binding hydrophobic cleft; other site
681645002028	dimer interface [polypeptide binding]; other site
681645002029	putative IPP diphosphate binding site; other site
681645002030	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
681645002031	pantothenate kinase; Provisional; Region: PRK05439
681645002032	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
681645002033	ATP-binding site [chemical binding]; other site
681645002034	CoA-binding site [chemical binding]; other site
681645002035	Mg2+-binding site [ion binding]; other site
681645002036	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
681645002037	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
681645002038	dimer interface [polypeptide binding]; other site
681645002039	active site
681645002040	glycine-pyridoxal phosphate binding site [chemical binding]; other site
681645002041	folate binding site [chemical binding]; other site
681645002042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645002043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645002044	putative substrate translocation pore; other site
681645002045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645002046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645002047	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
681645002048	dimerization interface [polypeptide binding]; other site
681645002049	Transcriptional regulator [Transcription]; Region: LysR; COG0583
681645002050	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
681645002051	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
681645002052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645002053	Coenzyme A binding pocket [chemical binding]; other site
681645002054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645002055	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
681645002056	putative substrate translocation pore; other site
681645002057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645002058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645002059	fumarate hydratase; Reviewed; Region: fumC; PRK00485
681645002060	Class II fumarases; Region: Fumarase_classII; cd01362
681645002061	active site
681645002062	tetramer interface [polypeptide binding]; other site
681645002063	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
681645002064	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
681645002065	putative active site [active]
681645002066	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
681645002067	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
681645002068	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
681645002069	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
681645002070	generic binding surface II; other site
681645002071	generic binding surface I; other site
681645002072	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
681645002073	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
681645002074	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
681645002075	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
681645002076	Domain of unknown function DUF20; Region: UPF0118; pfam01594
681645002077	GTP-binding protein YchF; Reviewed; Region: PRK09601
681645002078	YchF GTPase; Region: YchF; cd01900
681645002079	G1 box; other site
681645002080	GTP/Mg2+ binding site [chemical binding]; other site
681645002081	Switch I region; other site
681645002082	G2 box; other site
681645002083	Switch II region; other site
681645002084	G3 box; other site
681645002085	G4 box; other site
681645002086	G5 box; other site
681645002087	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
681645002088	Protein of unknown function, DUF488; Region: DUF488; pfam04343
681645002089	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
681645002090	PhnA protein; Region: PhnA; pfam03831
681645002091	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
681645002092	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
681645002093	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002094	Walker A/P-loop; other site
681645002095	ATP binding site [chemical binding]; other site
681645002096	Q-loop/lid; other site
681645002097	ABC transporter signature motif; other site
681645002098	Walker B; other site
681645002099	D-loop; other site
681645002100	H-loop/switch region; other site
681645002101	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
681645002102	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
681645002103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002104	Walker A/P-loop; other site
681645002105	ATP binding site [chemical binding]; other site
681645002106	Q-loop/lid; other site
681645002107	ABC transporter signature motif; other site
681645002108	Walker B; other site
681645002109	D-loop; other site
681645002110	H-loop/switch region; other site
681645002111	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002112	Walker A/P-loop; other site
681645002113	ATP binding site [chemical binding]; other site
681645002114	Q-loop/lid; other site
681645002115	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
681645002116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002117	Walker A/P-loop; other site
681645002118	ATP binding site [chemical binding]; other site
681645002119	Q-loop/lid; other site
681645002120	ABC transporter; Region: ABC_tran; pfam00005
681645002121	ABC transporter signature motif; other site
681645002122	Walker B; other site
681645002123	D-loop; other site
681645002124	H-loop/switch region; other site
681645002125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
681645002126	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
681645002127	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
681645002128	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
681645002129	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
681645002130	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
681645002131	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
681645002132	Walker A/P-loop; other site
681645002133	ATP binding site [chemical binding]; other site
681645002134	Q-loop/lid; other site
681645002135	ABC transporter signature motif; other site
681645002136	Walker B; other site
681645002137	D-loop; other site
681645002138	H-loop/switch region; other site
681645002139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002140	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
681645002141	Walker A/P-loop; other site
681645002142	ATP binding site [chemical binding]; other site
681645002143	Q-loop/lid; other site
681645002144	ABC transporter signature motif; other site
681645002145	Walker B; other site
681645002146	D-loop; other site
681645002147	H-loop/switch region; other site
681645002148	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
681645002149	hypothetical protein; Provisional; Region: PRK06547
681645002150	Predicted kinase [General function prediction only]; Region: COG0645
681645002151	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
681645002152	nudix motif; other site
681645002153	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
681645002154	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
681645002155	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
681645002156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645002157	dimer interface [polypeptide binding]; other site
681645002158	conserved gate region; other site
681645002159	ABC-ATPase subunit interface; other site
681645002160	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
681645002161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645002162	dimer interface [polypeptide binding]; other site
681645002163	conserved gate region; other site
681645002164	putative PBP binding loops; other site
681645002165	ABC-ATPase subunit interface; other site
681645002166	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
681645002167	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645002168	Walker A/P-loop; other site
681645002169	ATP binding site [chemical binding]; other site
681645002170	Q-loop/lid; other site
681645002171	ABC transporter signature motif; other site
681645002172	Walker B; other site
681645002173	D-loop; other site
681645002174	H-loop/switch region; other site
681645002175	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645002176	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645002177	Walker A/P-loop; other site
681645002178	ATP binding site [chemical binding]; other site
681645002179	Q-loop/lid; other site
681645002180	ABC transporter signature motif; other site
681645002181	Walker B; other site
681645002182	D-loop; other site
681645002183	H-loop/switch region; other site
681645002184	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645002185	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
681645002186	cleavage site
681645002187	active site
681645002188	substrate binding sites [chemical binding]; other site
681645002189	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
681645002190	ArsC family; Region: ArsC; pfam03960
681645002191	catalytic residues [active]
681645002192	Protein of unknown function (DUF402); Region: DUF402; cl00979
681645002193	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
681645002194	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
681645002195	G1 box; other site
681645002196	GTP/Mg2+ binding site [chemical binding]; other site
681645002197	G2 box; other site
681645002198	Switch I region; other site
681645002199	G3 box; other site
681645002200	Switch II region; other site
681645002201	G4 box; other site
681645002202	G5 box; other site
681645002203	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
681645002204	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
681645002205	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
681645002206	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
681645002207	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
681645002208	Ferredoxin [Energy production and conversion]; Region: COG1146
681645002209	4Fe-4S binding domain; Region: Fer4; pfam00037
681645002210	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
681645002211	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645002212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645002213	homodimer interface [polypeptide binding]; other site
681645002214	catalytic residue [active]
681645002215	Predicted membrane protein [Function unknown]; Region: COG2246
681645002216	GtrA-like protein; Region: GtrA; pfam04138
681645002217	Domain of unknown function (DUF222); Region: DUF222; pfam02720
681645002218	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
681645002219	active site
681645002220	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
681645002221	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
681645002222	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
681645002223	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
681645002224	putative trimer interface [polypeptide binding]; other site
681645002225	putative CoA binding site [chemical binding]; other site
681645002226	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
681645002227	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
681645002228	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
681645002229	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
681645002230	putative trimer interface [polypeptide binding]; other site
681645002231	putative CoA binding site [chemical binding]; other site
681645002232	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
681645002233	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
681645002234	metal binding site [ion binding]; metal-binding site
681645002235	putative dimer interface [polypeptide binding]; other site
681645002236	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
681645002237	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
681645002238	dihydropteroate synthase; Region: DHPS; TIGR01496
681645002239	substrate binding pocket [chemical binding]; other site
681645002240	dimer interface [polypeptide binding]; other site
681645002241	inhibitor binding site; inhibition site
681645002242	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
681645002243	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
681645002244	Ligand binding site; other site
681645002245	Putative Catalytic site; other site
681645002246	DXD motif; other site
681645002247	DivIVA domain; Region: DivI1A_domain; TIGR03544
681645002248	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
681645002249	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
681645002250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002251	S-adenosylmethionine binding site [chemical binding]; other site
681645002252	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
681645002253	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
681645002254	active site
681645002255	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
681645002256	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
681645002257	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
681645002258	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
681645002259	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
681645002260	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
681645002261	ligand binding site; other site
681645002262	oligomer interface; other site
681645002263	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
681645002264	dimer interface [polypeptide binding]; other site
681645002265	N-terminal domain interface [polypeptide binding]; other site
681645002266	sulfate 1 binding site; other site
681645002267	Methyltransferase domain; Region: Methyltransf_24; pfam13578
681645002268	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
681645002269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645002270	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645002271	DNA binding residues [nucleotide binding]
681645002272	sec-independent translocase; Provisional; Region: tatB; PRK00182
681645002273	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
681645002274	Domain of unknown function DUF59; Region: DUF59; pfam01883
681645002275	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
681645002276	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
681645002277	Predicted membrane protein [Function unknown]; Region: COG4420
681645002278	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
681645002279	MgtE intracellular N domain; Region: MgtE_N; smart00924
681645002280	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
681645002281	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
681645002282	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
681645002283	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
681645002284	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
681645002285	TPP-binding site [chemical binding]; other site
681645002286	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
681645002287	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
681645002288	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
681645002289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002290	Walker A/P-loop; other site
681645002291	ATP binding site [chemical binding]; other site
681645002292	Q-loop/lid; other site
681645002293	ABC transporter signature motif; other site
681645002294	Walker B; other site
681645002295	D-loop; other site
681645002296	H-loop/switch region; other site
681645002297	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
681645002298	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
681645002299	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002300	Walker A/P-loop; other site
681645002301	ATP binding site [chemical binding]; other site
681645002302	Q-loop/lid; other site
681645002303	ABC transporter signature motif; other site
681645002304	Walker B; other site
681645002305	D-loop; other site
681645002306	H-loop/switch region; other site
681645002307	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
681645002308	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
681645002309	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
681645002310	shikimate binding site; other site
681645002311	NAD(P) binding site [chemical binding]; other site
681645002312	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
681645002313	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
681645002314	substrate binding pocket [chemical binding]; other site
681645002315	catalytic triad [active]
681645002316	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
681645002317	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
681645002318	active site
681645002319	catalytic residues [active]
681645002320	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
681645002321	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
681645002322	Na binding site [ion binding]; other site
681645002323	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
681645002324	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
681645002325	nucleotide binding site/active site [active]
681645002326	HIT family signature motif; other site
681645002327	catalytic residue [active]
681645002328	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
681645002329	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
681645002330	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
681645002331	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
681645002332	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
681645002333	ATP binding site [chemical binding]; other site
681645002334	Mg++ binding site [ion binding]; other site
681645002335	motif III; other site
681645002336	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645002337	nucleotide binding region [chemical binding]; other site
681645002338	ATP-binding site [chemical binding]; other site
681645002339	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
681645002340	putative RNA binding site [nucleotide binding]; other site
681645002341	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
681645002342	dimer interface [polypeptide binding]; other site
681645002343	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
681645002344	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
681645002345	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
681645002346	Na binding site [ion binding]; other site
681645002347	SNF2 Helicase protein; Region: DUF3670; pfam12419
681645002348	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
681645002349	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645002350	ATP binding site [chemical binding]; other site
681645002351	putative Mg++ binding site [ion binding]; other site
681645002352	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645002353	nucleotide binding region [chemical binding]; other site
681645002354	ATP-binding site [chemical binding]; other site
681645002355	Uncharacterized conserved protein [Function unknown]; Region: COG4279
681645002356	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
681645002357	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
681645002358	active site
681645002359	metal binding site [ion binding]; metal-binding site
681645002360	DNA binding site [nucleotide binding]
681645002361	AAA domain; Region: AAA_23; pfam13476
681645002362	Uncharacterized conserved protein [Function unknown]; Region: COG2353
681645002363	Transcriptional regulators [Transcription]; Region: MarR; COG1846
681645002364	MarR family; Region: MarR_2; pfam12802
681645002365	PspC domain; Region: PspC; pfam04024
681645002366	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
681645002367	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
681645002368	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
681645002369	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
681645002370	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
681645002371	Cysteine-rich domain; Region: CCG; pfam02754
681645002372	Cysteine-rich domain; Region: CCG; pfam02754
681645002373	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
681645002374	L-lactate permease; Region: Lactate_perm; cl00701
681645002375	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
681645002376	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
681645002377	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
681645002378	active site
681645002379	HIGH motif; other site
681645002380	KMSK motif region; other site
681645002381	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
681645002382	tRNA binding surface [nucleotide binding]; other site
681645002383	anticodon binding site; other site
681645002384	diaminopimelate decarboxylase; Region: lysA; TIGR01048
681645002385	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
681645002386	active site
681645002387	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
681645002388	substrate binding site [chemical binding]; other site
681645002389	catalytic residues [active]
681645002390	dimer interface [polypeptide binding]; other site
681645002391	homoserine dehydrogenase; Provisional; Region: PRK06349
681645002392	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
681645002393	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
681645002394	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
681645002395	homoserine kinase; Provisional; Region: PRK01212
681645002396	Predicted transcriptional regulator [Transcription]; Region: COG2345
681645002397	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
681645002398	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
681645002399	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645002400	acyl-activating enzyme (AAE) consensus motif; other site
681645002401	AMP binding site [chemical binding]; other site
681645002402	active site
681645002403	CoA binding site [chemical binding]; other site
681645002404	transcription termination factor Rho; Provisional; Region: PRK12678
681645002405	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
681645002406	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
681645002407	RNA binding site [nucleotide binding]; other site
681645002408	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
681645002409	multimer interface [polypeptide binding]; other site
681645002410	Walker A motif; other site
681645002411	ATP binding site [chemical binding]; other site
681645002412	Walker B motif; other site
681645002413	peptide chain release factor 1; Validated; Region: prfA; PRK00591
681645002414	This domain is found in peptide chain release factors; Region: PCRF; smart00937
681645002415	RF-1 domain; Region: RF-1; pfam00472
681645002416	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
681645002417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002418	S-adenosylmethionine binding site [chemical binding]; other site
681645002419	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
681645002420	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
681645002421	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
681645002422	Mg++ binding site [ion binding]; other site
681645002423	putative catalytic motif [active]
681645002424	substrate binding site [chemical binding]; other site
681645002425	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
681645002426	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
681645002427	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
681645002428	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
681645002429	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
681645002430	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
681645002431	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
681645002432	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
681645002433	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
681645002434	beta subunit interaction interface [polypeptide binding]; other site
681645002435	Walker A motif; other site
681645002436	ATP binding site [chemical binding]; other site
681645002437	Walker B motif; other site
681645002438	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
681645002439	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
681645002440	core domain interface [polypeptide binding]; other site
681645002441	delta subunit interface [polypeptide binding]; other site
681645002442	epsilon subunit interface [polypeptide binding]; other site
681645002443	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
681645002444	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
681645002445	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
681645002446	alpha subunit interaction interface [polypeptide binding]; other site
681645002447	Walker A motif; other site
681645002448	ATP binding site [chemical binding]; other site
681645002449	Walker B motif; other site
681645002450	inhibitor binding site; inhibition site
681645002451	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
681645002452	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
681645002453	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
681645002454	gamma subunit interface [polypeptide binding]; other site
681645002455	epsilon subunit interface [polypeptide binding]; other site
681645002456	LBP interface [polypeptide binding]; other site
681645002457	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
681645002458	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
681645002459	hypothetical protein; Provisional; Region: PRK03298
681645002460	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
681645002461	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
681645002462	dimer interface [polypeptide binding]; other site
681645002463	substrate binding site [chemical binding]; other site
681645002464	metal binding site [ion binding]; metal-binding site
681645002465	Domain of unknown function DUF77; Region: DUF77; pfam01910
681645002466	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
681645002467	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
681645002468	glycogen branching enzyme; Provisional; Region: PRK05402
681645002469	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
681645002470	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
681645002471	active site
681645002472	catalytic site [active]
681645002473	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
681645002474	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
681645002475	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
681645002476	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
681645002477	active site
681645002478	catalytic site [active]
681645002479	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645002480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645002481	Walker A/P-loop; other site
681645002482	ATP binding site [chemical binding]; other site
681645002483	ABC transporter signature motif; other site
681645002484	Walker B; other site
681645002485	D-loop; other site
681645002486	H-loop/switch region; other site
681645002487	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
681645002488	Ligand binding site [chemical binding]; other site
681645002489	Electron transfer flavoprotein domain; Region: ETF; pfam01012
681645002490	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
681645002491	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
681645002492	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
681645002493	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
681645002494	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
681645002495	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
681645002496	catalytic residue [active]
681645002497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002498	S-adenosylmethionine binding site [chemical binding]; other site
681645002499	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
681645002500	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
681645002501	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
681645002502	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
681645002503	active site
681645002504	catalytic site [active]
681645002505	substrate binding site [chemical binding]; other site
681645002506	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
681645002507	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
681645002508	nucleotide binding pocket [chemical binding]; other site
681645002509	K-X-D-G motif; other site
681645002510	catalytic site [active]
681645002511	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
681645002512	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
681645002513	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
681645002514	Dimer interface [polypeptide binding]; other site
681645002515	BRCT sequence motif; other site
681645002516	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
681645002517	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
681645002518	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
681645002519	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
681645002520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
681645002521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645002522	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645002523	putative substrate translocation pore; other site
681645002524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645002525	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645002526	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645002527	ABC-ATPase subunit  interface; other site
681645002528	dimer interface [polypeptide binding]; other site
681645002529	putative PBP binding regions; other site
681645002530	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645002531	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645002532	Walker A/P-loop; other site
681645002533	ATP binding site [chemical binding]; other site
681645002534	Q-loop/lid; other site
681645002535	ABC transporter signature motif; other site
681645002536	Walker B; other site
681645002537	D-loop; other site
681645002538	H-loop/switch region; other site
681645002539	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
681645002540	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
681645002541	putative ligand binding residues [chemical binding]; other site
681645002542	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
681645002543	phosphofructokinase; Region: PFK_mixed; TIGR02483
681645002544	active site
681645002545	ADP/pyrophosphate binding site [chemical binding]; other site
681645002546	dimerization interface [polypeptide binding]; other site
681645002547	allosteric effector site; other site
681645002548	fructose-1,6-bisphosphate binding site; other site
681645002549	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
681645002550	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
681645002551	GatB domain; Region: GatB_Yqey; smart00845
681645002552	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
681645002553	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
681645002554	active site
681645002555	catalytic tetrad [active]
681645002556	Lysine efflux permease [General function prediction only]; Region: COG1279
681645002557	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
681645002558	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
681645002559	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
681645002560	dimerization interface [polypeptide binding]; other site
681645002561	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
681645002562	Predicted membrane protein [Function unknown]; Region: COG2259
681645002563	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
681645002564	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
681645002565	Mechanosensitive ion channel; Region: MS_channel; pfam00924
681645002566	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
681645002567	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
681645002568	putative valine binding site [chemical binding]; other site
681645002569	dimer interface [polypeptide binding]; other site
681645002570	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
681645002571	ketol-acid reductoisomerase; Provisional; Region: PRK05479
681645002572	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
681645002573	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
681645002574	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
681645002575	Uncharacterized conserved protein [Function unknown]; Region: COG1479
681645002576	Protein of unknown function DUF262; Region: DUF262; pfam03235
681645002577	Uncharacterized conserved protein [Function unknown]; Region: COG3472
681645002578	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
681645002579	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
681645002580	ligand binding site [chemical binding]; other site
681645002581	NAD binding site [chemical binding]; other site
681645002582	dimerization interface [polypeptide binding]; other site
681645002583	catalytic site [active]
681645002584	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
681645002585	putative L-serine binding site [chemical binding]; other site
681645002586	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
681645002587	tartrate dehydrogenase; Region: TTC; TIGR02089
681645002588	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
681645002589	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
681645002590	ligand binding site [chemical binding]; other site
681645002591	flexible hinge region; other site
681645002592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
681645002593	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
681645002594	metal binding triad; other site
681645002595	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
681645002596	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
681645002597	active site
681645002598	catalytic site [active]
681645002599	substrate binding site [chemical binding]; other site
681645002600	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
681645002601	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
681645002602	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
681645002603	isochorismate synthase DhbC; Validated; Region: PRK06923
681645002604	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
681645002605	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
681645002606	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645002607	HIGH motif; other site
681645002608	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
681645002609	active site
681645002610	KMSKS motif; other site
681645002611	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
681645002612	Cutinase; Region: Cutinase; pfam01083
681645002613	biotin synthase; Region: bioB; TIGR00433
681645002614	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645002615	FeS/SAM binding site; other site
681645002616	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
681645002617	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
681645002618	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
681645002619	Zn2+ binding site [ion binding]; other site
681645002620	Mg2+ binding site [ion binding]; other site
681645002621	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
681645002622	Transcriptional regulator [Transcription]; Region: IclR; COG1414
681645002623	Bacterial transcriptional regulator; Region: IclR; pfam01614
681645002624	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
681645002625	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
681645002626	substrate binding site [chemical binding]; other site
681645002627	ligand binding site [chemical binding]; other site
681645002628	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
681645002629	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
681645002630	substrate binding site [chemical binding]; other site
681645002631	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
681645002632	active site
681645002633	Ap6A binding site [chemical binding]; other site
681645002634	nudix motif; other site
681645002635	metal binding site [ion binding]; metal-binding site
681645002636	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645002637	catalytic core [active]
681645002638	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
681645002639	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
681645002640	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
681645002641	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
681645002642	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
681645002643	ATP-grasp domain; Region: ATP-grasp_4; cl17255
681645002644	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
681645002645	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
681645002646	thiamine monophosphate kinase; Provisional; Region: PRK05731
681645002647	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
681645002648	ATP binding site [chemical binding]; other site
681645002649	dimerization interface [polypeptide binding]; other site
681645002650	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
681645002651	ligand binding site [chemical binding]; other site
681645002652	active site
681645002653	UGI interface [polypeptide binding]; other site
681645002654	catalytic site [active]
681645002655	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
681645002656	DAK2 domain; Region: Dak2; pfam02734
681645002657	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
681645002658	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
681645002659	generic binding surface II; other site
681645002660	ssDNA binding site; other site
681645002661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645002662	ATP binding site [chemical binding]; other site
681645002663	putative Mg++ binding site [ion binding]; other site
681645002664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645002665	nucleotide binding region [chemical binding]; other site
681645002666	ATP-binding site [chemical binding]; other site
681645002667	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
681645002668	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
681645002669	carboxyltransferase (CT) interaction site; other site
681645002670	biotinylation site [posttranslational modification]; other site
681645002671	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
681645002672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002673	S-adenosylmethionine binding site [chemical binding]; other site
681645002674	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
681645002675	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
681645002676	active site
681645002677	(T/H)XGH motif; other site
681645002678	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
681645002679	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
681645002680	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
681645002681	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
681645002682	Walker A/P-loop; other site
681645002683	ATP binding site [chemical binding]; other site
681645002684	Q-loop/lid; other site
681645002685	ABC transporter signature motif; other site
681645002686	Walker B; other site
681645002687	D-loop; other site
681645002688	H-loop/switch region; other site
681645002689	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
681645002690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645002691	dimer interface [polypeptide binding]; other site
681645002692	conserved gate region; other site
681645002693	putative PBP binding loops; other site
681645002694	ABC-ATPase subunit interface; other site
681645002695	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
681645002696	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
681645002697	substrate binding pocket [chemical binding]; other site
681645002698	membrane-bound complex binding site; other site
681645002699	hinge residues; other site
681645002700	Domain of unknown function (DUF368); Region: DUF368; pfam04018
681645002701	DNA polymerase I; Provisional; Region: PRK05755
681645002702	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
681645002703	active site
681645002704	metal binding site 1 [ion binding]; metal-binding site
681645002705	putative 5' ssDNA interaction site; other site
681645002706	metal binding site 3; metal-binding site
681645002707	metal binding site 2 [ion binding]; metal-binding site
681645002708	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
681645002709	putative DNA binding site [nucleotide binding]; other site
681645002710	putative metal binding site [ion binding]; other site
681645002711	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
681645002712	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
681645002713	active site
681645002714	DNA binding site [nucleotide binding]
681645002715	catalytic site [active]
681645002716	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
681645002717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002718	S-adenosylmethionine binding site [chemical binding]; other site
681645002719	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
681645002720	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
681645002721	RNA binding site [nucleotide binding]; other site
681645002722	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
681645002723	RNA binding site [nucleotide binding]; other site
681645002724	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
681645002725	RNA binding site [nucleotide binding]; other site
681645002726	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
681645002727	RNA binding site [nucleotide binding]; other site
681645002728	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
681645002729	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
681645002730	active site turn [active]
681645002731	phosphorylation site [posttranslational modification]
681645002732	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
681645002733	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
681645002734	HPr interaction site; other site
681645002735	glycerol kinase (GK) interaction site [polypeptide binding]; other site
681645002736	active site
681645002737	phosphorylation site [posttranslational modification]
681645002738	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
681645002739	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
681645002740	CoA-binding site [chemical binding]; other site
681645002741	ATP-binding [chemical binding]; other site
681645002742	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
681645002743	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645002744	FeS/SAM binding site; other site
681645002745	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
681645002746	excinuclease ABC subunit B; Provisional; Region: PRK05298
681645002747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645002748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645002749	nucleotide binding region [chemical binding]; other site
681645002750	ATP-binding site [chemical binding]; other site
681645002751	Ultra-violet resistance protein B; Region: UvrB; pfam12344
681645002752	UvrB/uvrC motif; Region: UVR; pfam02151
681645002753	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
681645002754	Ligand Binding Site [chemical binding]; other site
681645002755	Predicted membrane protein [Function unknown]; Region: COG2259
681645002756	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
681645002757	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
681645002758	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
681645002759	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
681645002760	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
681645002761	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
681645002762	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
681645002763	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
681645002764	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
681645002765	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
681645002766	23S rRNA binding site [nucleotide binding]; other site
681645002767	L21 binding site [polypeptide binding]; other site
681645002768	L13 binding site [polypeptide binding]; other site
681645002769	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
681645002770	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
681645002771	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
681645002772	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
681645002773	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
681645002774	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
681645002775	dimer interface [polypeptide binding]; other site
681645002776	motif 1; other site
681645002777	active site
681645002778	motif 2; other site
681645002779	motif 3; other site
681645002780	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
681645002781	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
681645002782	putative tRNA-binding site [nucleotide binding]; other site
681645002783	B3/4 domain; Region: B3_4; pfam03483
681645002784	tRNA synthetase B5 domain; Region: B5; smart00874
681645002785	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
681645002786	dimer interface [polypeptide binding]; other site
681645002787	motif 1; other site
681645002788	motif 3; other site
681645002789	motif 2; other site
681645002790	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
681645002791	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
681645002792	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
681645002793	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
681645002794	heterotetramer interface [polypeptide binding]; other site
681645002795	active site pocket [active]
681645002796	cleavage site
681645002797	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
681645002798	feedback inhibition sensing region; other site
681645002799	homohexameric interface [polypeptide binding]; other site
681645002800	nucleotide binding site [chemical binding]; other site
681645002801	N-acetyl-L-glutamate binding site [chemical binding]; other site
681645002802	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
681645002803	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
681645002804	inhibitor-cofactor binding pocket; inhibition site
681645002805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645002806	catalytic residue [active]
681645002807	ornithine carbamoyltransferase; Provisional; Region: PRK00779
681645002808	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
681645002809	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
681645002810	arginine repressor; Provisional; Region: PRK03341
681645002811	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
681645002812	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
681645002813	argininosuccinate synthase; Provisional; Region: PRK13820
681645002814	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
681645002815	ANP binding site [chemical binding]; other site
681645002816	Substrate Binding Site II [chemical binding]; other site
681645002817	Substrate Binding Site I [chemical binding]; other site
681645002818	argininosuccinate lyase; Provisional; Region: PRK00855
681645002819	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
681645002820	active sites [active]
681645002821	tetramer interface [polypeptide binding]; other site
681645002822	Uncharacterized conserved protein [Function unknown]; Region: COG2835
681645002823	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
681645002824	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
681645002825	active site
681645002826	HIGH motif; other site
681645002827	dimer interface [polypeptide binding]; other site
681645002828	KMSKS motif; other site
681645002829	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
681645002830	RNA binding surface [nucleotide binding]; other site
681645002831	transcription termination factor Rho; Provisional; Region: PRK12678
681645002832	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
681645002833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645002834	active site
681645002835	motif I; other site
681645002836	motif II; other site
681645002837	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645002838	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
681645002839	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
681645002840	RNA binding surface [nucleotide binding]; other site
681645002841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002842	S-adenosylmethionine binding site [chemical binding]; other site
681645002843	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
681645002844	ATP-NAD kinase; Region: NAD_kinase; pfam01513
681645002845	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
681645002846	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
681645002847	Walker A/P-loop; other site
681645002848	ATP binding site [chemical binding]; other site
681645002849	Q-loop/lid; other site
681645002850	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
681645002851	ABC transporter signature motif; other site
681645002852	Walker B; other site
681645002853	D-loop; other site
681645002854	H-loop/switch region; other site
681645002855	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
681645002856	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
681645002857	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
681645002858	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
681645002859	dimer interface [polypeptide binding]; other site
681645002860	ADP-ribose binding site [chemical binding]; other site
681645002861	active site
681645002862	nudix motif; other site
681645002863	metal binding site [ion binding]; metal-binding site
681645002864	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
681645002865	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
681645002866	active site
681645002867	Int/Topo IB signature motif; other site
681645002868	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
681645002869	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
681645002870	P-loop; other site
681645002871	Magnesium ion binding site [ion binding]; other site
681645002872	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
681645002873	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
681645002874	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
681645002875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645002876	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
681645002877	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
681645002878	inhibitor-cofactor binding pocket; inhibition site
681645002879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645002880	catalytic residue [active]
681645002881	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
681645002882	AAA domain; Region: AAA_26; pfam13500
681645002883	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
681645002884	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
681645002885	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
681645002886	RNA binding surface [nucleotide binding]; other site
681645002887	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
681645002888	active site
681645002889	cytidylate kinase; Provisional; Region: cmk; PRK00023
681645002890	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
681645002891	CMP-binding site; other site
681645002892	The sites determining sugar specificity; other site
681645002893	GTP-binding protein Der; Reviewed; Region: PRK03003
681645002894	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
681645002895	G1 box; other site
681645002896	GTP/Mg2+ binding site [chemical binding]; other site
681645002897	Switch I region; other site
681645002898	G2 box; other site
681645002899	Switch II region; other site
681645002900	G3 box; other site
681645002901	G4 box; other site
681645002902	G5 box; other site
681645002903	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
681645002904	G1 box; other site
681645002905	GTP/Mg2+ binding site [chemical binding]; other site
681645002906	Switch I region; other site
681645002907	G2 box; other site
681645002908	G3 box; other site
681645002909	Switch II region; other site
681645002910	G4 box; other site
681645002911	G5 box; other site
681645002912	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
681645002913	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
681645002914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002915	S-adenosylmethionine binding site [chemical binding]; other site
681645002916	Predicted esterase [General function prediction only]; Region: COG0627
681645002917	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
681645002918	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
681645002919	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645002920	intersubunit interface [polypeptide binding]; other site
681645002921	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645002922	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645002923	dimer interface [polypeptide binding]; other site
681645002924	ABC-ATPase subunit  interface; other site
681645002925	putative PBP binding regions; other site
681645002926	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645002927	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645002928	ABC-ATPase subunit  interface; other site
681645002929	dimer interface [polypeptide binding]; other site
681645002930	putative PBP binding regions; other site
681645002931	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645002932	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645002933	Walker A/P-loop; other site
681645002934	ATP binding site [chemical binding]; other site
681645002935	Q-loop/lid; other site
681645002936	ABC transporter signature motif; other site
681645002937	Walker B; other site
681645002938	D-loop; other site
681645002939	H-loop/switch region; other site
681645002940	IucA / IucC family; Region: IucA_IucC; pfam04183
681645002941	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
681645002942	IucA / IucC family; Region: IucA_IucC; pfam04183
681645002943	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
681645002944	H+ Antiporter protein; Region: 2A0121; TIGR00900
681645002945	hypothetical protein; Provisional; Region: PRK01842
681645002946	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
681645002947	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
681645002948	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
681645002949	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
681645002950	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
681645002951	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645002952	nucleotide binding region [chemical binding]; other site
681645002953	ATP-binding site [chemical binding]; other site
681645002954	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
681645002955	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
681645002956	phosphopeptide binding site; other site
681645002957	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
681645002958	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
681645002959	DNA binding residues [nucleotide binding]
681645002960	Bifunctional nuclease; Region: DNase-RNase; pfam02577
681645002961	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
681645002962	DNA binding residues [nucleotide binding]
681645002963	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
681645002964	putative dimer interface [polypeptide binding]; other site
681645002965	Domain of unknown function DUF21; Region: DUF21; pfam01595
681645002966	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
681645002967	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
681645002968	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
681645002969	Domain of unknown function DUF21; Region: DUF21; pfam01595
681645002970	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
681645002971	Transporter associated domain; Region: CorC_HlyC; smart01091
681645002972	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
681645002973	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
681645002974	ATP binding site [chemical binding]; other site
681645002975	putative Mg++ binding site [ion binding]; other site
681645002976	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645002977	nucleotide binding region [chemical binding]; other site
681645002978	ATP-binding site [chemical binding]; other site
681645002979	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
681645002980	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
681645002981	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
681645002982	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
681645002983	CoenzymeA binding site [chemical binding]; other site
681645002984	subunit interaction site [polypeptide binding]; other site
681645002985	PHB binding site; other site
681645002986	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
681645002987	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
681645002988	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
681645002989	oligomer interface [polypeptide binding]; other site
681645002990	metal binding site [ion binding]; metal-binding site
681645002991	metal binding site [ion binding]; metal-binding site
681645002992	putative Cl binding site [ion binding]; other site
681645002993	basic sphincter; other site
681645002994	hydrophobic gate; other site
681645002995	periplasmic entrance; other site
681645002996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645002997	S-adenosylmethionine binding site [chemical binding]; other site
681645002998	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
681645002999	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
681645003000	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
681645003001	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
681645003002	metabolite-proton symporter; Region: 2A0106; TIGR00883
681645003003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645003004	putative substrate translocation pore; other site
681645003005	YceI-like domain; Region: YceI; pfam04264
681645003006	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
681645003007	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
681645003008	Ligand binding site; other site
681645003009	Putative Catalytic site; other site
681645003010	DXD motif; other site
681645003011	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
681645003012	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
681645003013	putative active site [active]
681645003014	catalytic triad [active]
681645003015	putative dimer interface [polypeptide binding]; other site
681645003016	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
681645003017	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
681645003018	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
681645003019	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
681645003020	precorrin-3B synthase; Region: CobG; TIGR02435
681645003021	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
681645003022	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
681645003023	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
681645003024	Precorrin-8X methylmutase; Region: CbiC; pfam02570
681645003025	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
681645003026	active site
681645003027	SAM binding site [chemical binding]; other site
681645003028	homodimer interface [polypeptide binding]; other site
681645003029	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
681645003030	active site
681645003031	SAM binding site [chemical binding]; other site
681645003032	homodimer interface [polypeptide binding]; other site
681645003033	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
681645003034	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
681645003035	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
681645003036	active site
681645003037	SAM binding site [chemical binding]; other site
681645003038	homodimer interface [polypeptide binding]; other site
681645003039	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
681645003040	active site
681645003041	putative homodimer interface [polypeptide binding]; other site
681645003042	SAM binding site [chemical binding]; other site
681645003043	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
681645003044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645003045	S-adenosylmethionine binding site [chemical binding]; other site
681645003046	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
681645003047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645003048	NAD(P) binding site [chemical binding]; other site
681645003049	active site
681645003050	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
681645003051	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
681645003052	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
681645003053	active site
681645003054	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
681645003055	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645003056	ATP binding site [chemical binding]; other site
681645003057	putative Mg++ binding site [ion binding]; other site
681645003058	helicase superfamily c-terminal domain; Region: HELICc; smart00490
681645003059	nucleotide binding region [chemical binding]; other site
681645003060	ATP-binding site [chemical binding]; other site
681645003061	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
681645003062	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
681645003063	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
681645003064	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
681645003065	Predicted transcriptional regulator [Transcription]; Region: COG2378
681645003066	WYL domain; Region: WYL; pfam13280
681645003067	Predicted transcriptional regulator [Transcription]; Region: COG2378
681645003068	WYL domain; Region: WYL; pfam13280
681645003069	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
681645003070	Pup-like protein; Region: Pup; pfam05639
681645003071	Pup-ligase protein; Region: Pup_ligase; cl15463
681645003072	proteasome ATPase; Region: pup_AAA; TIGR03689
681645003073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645003074	Walker A motif; other site
681645003075	ATP binding site [chemical binding]; other site
681645003076	Walker B motif; other site
681645003077	arginine finger; other site
681645003078	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
681645003079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
681645003080	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
681645003081	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
681645003082	active site
681645003083	metal binding site [ion binding]; metal-binding site
681645003084	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
681645003085	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
681645003086	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
681645003087	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
681645003088	Potassium binding sites [ion binding]; other site
681645003089	Cesium cation binding sites [ion binding]; other site
681645003090	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
681645003091	Aspartase; Region: Aspartase; cd01357
681645003092	active sites [active]
681645003093	tetramer interface [polypeptide binding]; other site
681645003094	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
681645003095	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
681645003096	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
681645003097	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
681645003098	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
681645003099	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
681645003100	homodimer interface [polypeptide binding]; other site
681645003101	putative metal binding site [ion binding]; other site
681645003102	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
681645003103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645003104	motif II; other site
681645003105	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
681645003106	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
681645003107	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
681645003108	substrate binding pocket [chemical binding]; other site
681645003109	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
681645003110	B12 binding site [chemical binding]; other site
681645003111	cobalt ligand [ion binding]; other site
681645003112	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
681645003113	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
681645003114	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645003115	active site
681645003116	HIGH motif; other site
681645003117	nucleotide binding site [chemical binding]; other site
681645003118	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645003119	active site
681645003120	KMSKS motif; other site
681645003121	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
681645003122	tRNA binding surface [nucleotide binding]; other site
681645003123	anticodon binding site; other site
681645003124	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
681645003125	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
681645003126	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
681645003127	active site
681645003128	catalytic tetrad [active]
681645003129	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
681645003130	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
681645003131	quinone interaction residues [chemical binding]; other site
681645003132	active site
681645003133	catalytic residues [active]
681645003134	FMN binding site [chemical binding]; other site
681645003135	substrate binding site [chemical binding]; other site
681645003136	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
681645003137	substrate binding site [chemical binding]; other site
681645003138	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
681645003139	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
681645003140	dimerization domain swap beta strand [polypeptide binding]; other site
681645003141	regulatory protein interface [polypeptide binding]; other site
681645003142	active site
681645003143	regulatory phosphorylation site [posttranslational modification]; other site
681645003144	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
681645003145	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
681645003146	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
681645003147	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
681645003148	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645003149	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
681645003150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645003151	NAD(P) binding site [chemical binding]; other site
681645003152	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
681645003153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645003154	NAD(P) binding site [chemical binding]; other site
681645003155	active site
681645003156	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
681645003157	GTP/Mg2+ binding site [chemical binding]; other site
681645003158	G4 box; other site
681645003159	membrane ATPase/protein kinase; Provisional; Region: PRK09435
681645003160	G5 box; other site
681645003161	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
681645003162	Walker A; other site
681645003163	G1 box; other site
681645003164	Switch I region; other site
681645003165	G2 box; other site
681645003166	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
681645003167	G4 box; other site
681645003168	G5 box; other site
681645003169	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
681645003170	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
681645003171	active site
681645003172	substrate binding site [chemical binding]; other site
681645003173	coenzyme B12 binding site [chemical binding]; other site
681645003174	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
681645003175	B12 binding site [chemical binding]; other site
681645003176	cobalt ligand [ion binding]; other site
681645003177	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
681645003178	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
681645003179	heterodimer interface [polypeptide binding]; other site
681645003180	substrate interaction site [chemical binding]; other site
681645003181	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
681645003182	Uncharacterized conserved protein [Function unknown]; Region: COG0398
681645003183	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
681645003184	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
681645003185	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
681645003186	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
681645003187	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
681645003188	ferrochelatase; Reviewed; Region: hemH; PRK00035
681645003189	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
681645003190	C-terminal domain interface [polypeptide binding]; other site
681645003191	active site
681645003192	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
681645003193	active site
681645003194	N-terminal domain interface [polypeptide binding]; other site
681645003195	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
681645003196	NlpC/P60 family; Region: NLPC_P60; pfam00877
681645003197	pyruvate carboxylase subunit A; Validated; Region: PRK07178
681645003198	aconitate hydratase; Validated; Region: PRK09277
681645003199	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
681645003200	substrate binding site [chemical binding]; other site
681645003201	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
681645003202	ligand binding site [chemical binding]; other site
681645003203	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
681645003204	substrate binding site [chemical binding]; other site
681645003205	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
681645003206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645003207	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
681645003208	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128
681645003209	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
681645003210	catalytic triad [active]
681645003211	conserved cys residue [active]
681645003212	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
681645003213	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
681645003214	AAA ATPase domain; Region: AAA_16; pfam13191
681645003215	AAA domain; Region: AAA_22; pfam13401
681645003216	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
681645003217	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645003218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645003219	Walker A/P-loop; other site
681645003220	ATP binding site [chemical binding]; other site
681645003221	Q-loop/lid; other site
681645003222	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645003223	ABC transporter signature motif; other site
681645003224	Walker B; other site
681645003225	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645003226	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
681645003227	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
681645003228	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
681645003229	trimerization site [polypeptide binding]; other site
681645003230	active site
681645003231	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
681645003232	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
681645003233	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
681645003234	catalytic residue [active]
681645003235	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
681645003236	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
681645003237	Walker A/P-loop; other site
681645003238	ATP binding site [chemical binding]; other site
681645003239	Q-loop/lid; other site
681645003240	ABC transporter signature motif; other site
681645003241	Walker B; other site
681645003242	D-loop; other site
681645003243	H-loop/switch region; other site
681645003244	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
681645003245	FeS assembly protein SufD; Region: sufD; TIGR01981
681645003246	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
681645003247	FeS assembly protein SufB; Region: sufB; TIGR01980
681645003248	Predicted transcriptional regulator [Transcription]; Region: COG2345
681645003249	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
681645003250	putative DNA binding site [nucleotide binding]; other site
681645003251	putative Zn2+ binding site [ion binding]; other site
681645003252	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
681645003253	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
681645003254	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
681645003255	Walker A/P-loop; other site
681645003256	ATP binding site [chemical binding]; other site
681645003257	Q-loop/lid; other site
681645003258	ABC transporter signature motif; other site
681645003259	Walker B; other site
681645003260	D-loop; other site
681645003261	H-loop/switch region; other site
681645003262	ABC-2 type transporter; Region: ABC2_membrane; cl17235
681645003263	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
681645003264	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
681645003265	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
681645003266	UbiA prenyltransferase family; Region: UbiA; pfam01040
681645003267	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
681645003268	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
681645003269	TPP-binding site [chemical binding]; other site
681645003270	dimer interface [polypeptide binding]; other site
681645003271	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
681645003272	PYR/PP interface [polypeptide binding]; other site
681645003273	dimer interface [polypeptide binding]; other site
681645003274	TPP binding site [chemical binding]; other site
681645003275	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
681645003276	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
681645003277	putative active site [active]
681645003278	transaldolase; Provisional; Region: PRK03903
681645003279	catalytic residue [active]
681645003280	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
681645003281	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
681645003282	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
681645003283	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
681645003284	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
681645003285	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
681645003286	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
681645003287	putative active site [active]
681645003288	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
681645003289	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
681645003290	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
681645003291	triosephosphate isomerase; Provisional; Region: PRK14567
681645003292	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
681645003293	substrate binding site [chemical binding]; other site
681645003294	dimer interface [polypeptide binding]; other site
681645003295	catalytic triad [active]
681645003296	Phosphoglycerate kinase; Region: PGK; pfam00162
681645003297	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
681645003298	substrate binding site [chemical binding]; other site
681645003299	hinge regions; other site
681645003300	ADP binding site [chemical binding]; other site
681645003301	catalytic site [active]
681645003302	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
681645003303	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
681645003304	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
681645003305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
681645003306	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
681645003307	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
681645003308	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
681645003309	phosphate binding site [ion binding]; other site
681645003310	putative substrate binding pocket [chemical binding]; other site
681645003311	dimer interface [polypeptide binding]; other site
681645003312	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
681645003313	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
681645003314	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
681645003315	GIY-YIG motif/motif A; other site
681645003316	active site
681645003317	catalytic site [active]
681645003318	putative DNA binding site [nucleotide binding]; other site
681645003319	metal binding site [ion binding]; metal-binding site
681645003320	UvrB/uvrC motif; Region: UVR; pfam02151
681645003321	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
681645003322	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
681645003323	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
681645003324	homopentamer interface [polypeptide binding]; other site
681645003325	active site
681645003326	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
681645003327	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
681645003328	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
681645003329	dimerization interface [polypeptide binding]; other site
681645003330	active site
681645003331	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
681645003332	Lumazine binding domain; Region: Lum_binding; pfam00677
681645003333	Lumazine binding domain; Region: Lum_binding; pfam00677
681645003334	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
681645003335	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
681645003336	catalytic motif [active]
681645003337	Zn binding site [ion binding]; other site
681645003338	RibD C-terminal domain; Region: RibD_C; pfam01872
681645003339	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
681645003340	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
681645003341	substrate binding site [chemical binding]; other site
681645003342	hexamer interface [polypeptide binding]; other site
681645003343	metal binding site [ion binding]; metal-binding site
681645003344	16S rRNA methyltransferase B; Provisional; Region: PRK14902
681645003345	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
681645003346	putative RNA binding site [nucleotide binding]; other site
681645003347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645003348	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
681645003349	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
681645003350	putative active site [active]
681645003351	substrate binding site [chemical binding]; other site
681645003352	putative cosubstrate binding site; other site
681645003353	catalytic site [active]
681645003354	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
681645003355	substrate binding site [chemical binding]; other site
681645003356	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
681645003357	active site
681645003358	catalytic residues [active]
681645003359	metal binding site [ion binding]; metal-binding site
681645003360	primosome assembly protein PriA; Provisional; Region: PRK14873
681645003361	S-adenosylmethionine synthetase; Validated; Region: PRK05250
681645003362	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
681645003363	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
681645003364	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
681645003365	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
681645003366	Flavoprotein; Region: Flavoprotein; pfam02441
681645003367	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
681645003368	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
681645003369	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
681645003370	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
681645003371	catalytic site [active]
681645003372	G-X2-G-X-G-K; other site
681645003373	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
681645003374	active site
681645003375	dimer interface [polypeptide binding]; other site
681645003376	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
681645003377	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
681645003378	ATP-grasp domain; Region: ATP-grasp_4; cl17255
681645003379	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
681645003380	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
681645003381	ATP-grasp domain; Region: ATP-grasp_4; cl17255
681645003382	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
681645003383	IMP binding site; other site
681645003384	dimer interface [polypeptide binding]; other site
681645003385	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
681645003386	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
681645003387	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
681645003388	catalytic site [active]
681645003389	subunit interface [polypeptide binding]; other site
681645003390	dihydroorotase; Validated; Region: pyrC; PRK09357
681645003391	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
681645003392	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
681645003393	active site
681645003394	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
681645003395	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
681645003396	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
681645003397	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
681645003398	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645003399	active site
681645003400	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
681645003401	putative hydrophobic ligand binding site [chemical binding]; other site
681645003402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645003403	TIGR01777 family protein; Region: yfcH
681645003404	NAD(P) binding site [chemical binding]; other site
681645003405	active site
681645003406	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
681645003407	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
681645003408	putative RNA binding site [nucleotide binding]; other site
681645003409	elongation factor P; Validated; Region: PRK00529
681645003410	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
681645003411	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
681645003412	RNA binding site [nucleotide binding]; other site
681645003413	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
681645003414	RNA binding site [nucleotide binding]; other site
681645003415	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
681645003416	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
681645003417	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
681645003418	active site
681645003419	Dehydroquinase class II; Region: DHquinase_II; pfam01220
681645003420	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
681645003421	trimer interface [polypeptide binding]; other site
681645003422	active site
681645003423	dimer interface [polypeptide binding]; other site
681645003424	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
681645003425	active site
681645003426	dimer interface [polypeptide binding]; other site
681645003427	metal binding site [ion binding]; metal-binding site
681645003428	shikimate kinase; Reviewed; Region: aroK; PRK00131
681645003429	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
681645003430	ADP binding site [chemical binding]; other site
681645003431	magnesium binding site [ion binding]; other site
681645003432	putative shikimate binding site; other site
681645003433	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
681645003434	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
681645003435	Tetramer interface [polypeptide binding]; other site
681645003436	active site
681645003437	FMN-binding site [chemical binding]; other site
681645003438	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
681645003439	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
681645003440	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
681645003441	shikimate binding site; other site
681645003442	NAD(P) binding site [chemical binding]; other site
681645003443	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
681645003444	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
681645003445	dimerization interface [polypeptide binding]; other site
681645003446	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
681645003447	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
681645003448	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
681645003449	motif 1; other site
681645003450	active site
681645003451	motif 2; other site
681645003452	motif 3; other site
681645003453	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
681645003454	DHHA1 domain; Region: DHHA1; pfam02272
681645003455	recombination factor protein RarA; Reviewed; Region: PRK13342
681645003456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645003457	Walker A motif; other site
681645003458	ATP binding site [chemical binding]; other site
681645003459	Walker B motif; other site
681645003460	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
681645003461	Phosphotransferase enzyme family; Region: APH; pfam01636
681645003462	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
681645003463	substrate binding site [chemical binding]; other site
681645003464	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
681645003465	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
681645003466	dimer interface [polypeptide binding]; other site
681645003467	anticodon binding site; other site
681645003468	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
681645003469	homodimer interface [polypeptide binding]; other site
681645003470	motif 1; other site
681645003471	active site
681645003472	motif 2; other site
681645003473	GAD domain; Region: GAD; pfam02938
681645003474	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
681645003475	active site
681645003476	motif 3; other site
681645003477	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
681645003478	DEAD-like helicases superfamily; Region: DEXDc; smart00487
681645003479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645003480	ATP binding site [chemical binding]; other site
681645003481	putative Mg++ binding site [ion binding]; other site
681645003482	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645003483	nucleotide binding region [chemical binding]; other site
681645003484	ATP-binding site [chemical binding]; other site
681645003485	Predicted membrane protein [Function unknown]; Region: COG1511
681645003486	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
681645003487	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
681645003488	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
681645003489	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
681645003490	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
681645003491	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645003492	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645003493	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
681645003494	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
681645003495	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
681645003496	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
681645003497	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
681645003498	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
681645003499	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
681645003500	putative active site [active]
681645003501	putative catalytic site [active]
681645003502	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
681645003503	CoA-transferase family III; Region: CoA_transf_3; pfam02515
681645003504	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
681645003505	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
681645003506	dimer interface [polypeptide binding]; other site
681645003507	motif 1; other site
681645003508	active site
681645003509	motif 2; other site
681645003510	motif 3; other site
681645003511	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
681645003512	anticodon binding site; other site
681645003513	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
681645003514	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
681645003515	dimer interface [polypeptide binding]; other site
681645003516	catalytic triad [active]
681645003517	peroxidatic and resolving cysteines [active]
681645003518	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
681645003519	active site
681645003520	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
681645003521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
681645003522	Zn2+ binding site [ion binding]; other site
681645003523	Mg2+ binding site [ion binding]; other site
681645003524	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
681645003525	synthetase active site [active]
681645003526	NTP binding site [chemical binding]; other site
681645003527	metal binding site [ion binding]; metal-binding site
681645003528	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
681645003529	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
681645003530	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645003531	active site
681645003532	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
681645003533	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
681645003534	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
681645003535	Protein export membrane protein; Region: SecD_SecF; pfam02355
681645003536	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
681645003537	Protein export membrane protein; Region: SecD_SecF; cl14618
681645003538	Preprotein translocase subunit; Region: YajC; pfam02699
681645003539	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
681645003540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645003541	Walker A motif; other site
681645003542	ATP binding site [chemical binding]; other site
681645003543	Walker B motif; other site
681645003544	arginine finger; other site
681645003545	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
681645003546	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
681645003547	RuvA N terminal domain; Region: RuvA_N; pfam01330
681645003548	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
681645003549	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
681645003550	active site
681645003551	putative DNA-binding cleft [nucleotide binding]; other site
681645003552	dimer interface [polypeptide binding]; other site
681645003553	hypothetical protein; Validated; Region: PRK00110
681645003554	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
681645003555	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
681645003556	active site
681645003557	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
681645003558	catalytic triad [active]
681645003559	dimer interface [polypeptide binding]; other site
681645003560	Protein of unknown function (DUF998); Region: DUF998; pfam06197
681645003561	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
681645003562	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
681645003563	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
681645003564	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
681645003565	catalytic residue [active]
681645003566	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
681645003567	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
681645003568	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
681645003569	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
681645003570	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
681645003571	putative acyl-acceptor binding pocket; other site
681645003572	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
681645003573	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
681645003574	nucleotide binding site/active site [active]
681645003575	HIT family signature motif; other site
681645003576	catalytic residue [active]
681645003577	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
681645003578	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
681645003579	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
681645003580	active site
681645003581	dimer interface [polypeptide binding]; other site
681645003582	motif 1; other site
681645003583	motif 2; other site
681645003584	motif 3; other site
681645003585	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
681645003586	anticodon binding site; other site
681645003587	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
681645003588	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
681645003589	Protein of unknown function (DUF461); Region: DUF461; pfam04314
681645003590	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
681645003591	hypothetical protein; Provisional; Region: PRK14059
681645003592	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
681645003593	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
681645003594	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
681645003595	SelR domain; Region: SelR; pfam01641
681645003596	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
681645003597	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
681645003598	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
681645003599	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
681645003600	catalytic site [active]
681645003601	putative active site [active]
681645003602	putative substrate binding site [chemical binding]; other site
681645003603	HRDC domain; Region: HRDC; pfam00570
681645003604	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
681645003605	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
681645003606	TPP-binding site; other site
681645003607	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
681645003608	PYR/PP interface [polypeptide binding]; other site
681645003609	dimer interface [polypeptide binding]; other site
681645003610	TPP binding site [chemical binding]; other site
681645003611	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
681645003612	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
681645003613	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
681645003614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645003615	S-adenosylmethionine binding site [chemical binding]; other site
681645003616	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
681645003617	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
681645003618	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
681645003619	trimer interface [polypeptide binding]; other site
681645003620	active site
681645003621	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
681645003622	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
681645003623	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
681645003624	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
681645003625	nucleotide binding site [chemical binding]; other site
681645003626	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
681645003627	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
681645003628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645003629	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
681645003630	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645003631	DNA binding residues [nucleotide binding]
681645003632	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
681645003633	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645003634	ATP binding site [chemical binding]; other site
681645003635	putative Mg++ binding site [ion binding]; other site
681645003636	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
681645003637	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
681645003638	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
681645003639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645003640	S-adenosylmethionine binding site [chemical binding]; other site
681645003641	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
681645003642	putative active site [active]
681645003643	dimerization interface [polypeptide binding]; other site
681645003644	putative tRNAtyr binding site [nucleotide binding]; other site
681645003645	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
681645003646	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
681645003647	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645003648	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
681645003649	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645003650	DNA binding residues [nucleotide binding]
681645003651	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
681645003652	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
681645003653	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
681645003654	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
681645003655	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
681645003656	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
681645003657	NAD binding site [chemical binding]; other site
681645003658	homodimer interface [polypeptide binding]; other site
681645003659	active site
681645003660	substrate binding site [chemical binding]; other site
681645003661	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
681645003662	PAC2 family; Region: PAC2; pfam09754
681645003663	DEAD-like helicases superfamily; Region: DEXDc; smart00487
681645003664	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645003665	ATP binding site [chemical binding]; other site
681645003666	putative Mg++ binding site [ion binding]; other site
681645003667	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645003668	nucleotide binding region [chemical binding]; other site
681645003669	ATP-binding site [chemical binding]; other site
681645003670	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
681645003671	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
681645003672	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
681645003673	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
681645003674	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
681645003675	dimer interface [polypeptide binding]; other site
681645003676	decamer (pentamer of dimers) interface [polypeptide binding]; other site
681645003677	catalytic triad [active]
681645003678	peroxidatic and resolving cysteines [active]
681645003679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
681645003680	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
681645003681	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
681645003682	dimerization interface [polypeptide binding]; other site
681645003683	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
681645003684	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
681645003685	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645003686	ATP binding site [chemical binding]; other site
681645003687	putative Mg++ binding site [ion binding]; other site
681645003688	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
681645003689	nucleotide binding region [chemical binding]; other site
681645003690	ATP-binding site [chemical binding]; other site
681645003691	Helicase associated domain (HA2); Region: HA2; pfam04408
681645003692	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
681645003693	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
681645003694	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
681645003695	ATP cone domain; Region: ATP-cone; pfam03477
681645003696	LexA repressor; Validated; Region: PRK00215
681645003697	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
681645003698	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
681645003699	Catalytic site [active]
681645003700	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
681645003701	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
681645003702	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
681645003703	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
681645003704	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
681645003705	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
681645003706	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
681645003707	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
681645003708	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
681645003709	DNA-binding site [nucleotide binding]; DNA binding site
681645003710	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
681645003711	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
681645003712	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
681645003713	putative substrate binding site [chemical binding]; other site
681645003714	putative ATP binding site [chemical binding]; other site
681645003715	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
681645003716	active site
681645003717	phosphorylation site [posttranslational modification]
681645003718	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
681645003719	active site
681645003720	P-loop; other site
681645003721	phosphorylation site [posttranslational modification]
681645003722	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
681645003723	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
681645003724	dimerization domain swap beta strand [polypeptide binding]; other site
681645003725	regulatory protein interface [polypeptide binding]; other site
681645003726	active site
681645003727	regulatory phosphorylation site [posttranslational modification]; other site
681645003728	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
681645003729	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
681645003730	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
681645003731	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
681645003732	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
681645003733	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
681645003734	GTPases [General function prediction only]; Region: HflX; COG2262
681645003735	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
681645003736	HflX GTPase family; Region: HflX; cd01878
681645003737	G1 box; other site
681645003738	GTP/Mg2+ binding site [chemical binding]; other site
681645003739	Switch I region; other site
681645003740	G2 box; other site
681645003741	G3 box; other site
681645003742	Switch II region; other site
681645003743	G4 box; other site
681645003744	G5 box; other site
681645003745	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
681645003746	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
681645003747	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
681645003748	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
681645003749	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
681645003750	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
681645003751	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
681645003752	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
681645003753	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
681645003754	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
681645003755	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645003756	FeS/SAM binding site; other site
681645003757	recombination regulator RecX; Reviewed; Region: recX; PRK00117
681645003758	recombinase A; Provisional; Region: recA; PRK09354
681645003759	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
681645003760	hexamer interface [polypeptide binding]; other site
681645003761	Walker A motif; other site
681645003762	ATP binding site [chemical binding]; other site
681645003763	Walker B motif; other site
681645003764	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
681645003765	BioY family; Region: BioY; pfam02632
681645003766	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
681645003767	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
681645003768	Walker A/P-loop; other site
681645003769	ATP binding site [chemical binding]; other site
681645003770	Q-loop/lid; other site
681645003771	ABC transporter signature motif; other site
681645003772	Walker B; other site
681645003773	D-loop; other site
681645003774	H-loop/switch region; other site
681645003775	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
681645003776	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
681645003777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
681645003778	sequence-specific DNA binding site [nucleotide binding]; other site
681645003779	salt bridge; other site
681645003780	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
681645003781	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
681645003782	YCII-related domain; Region: YCII; cl00999
681645003783	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
681645003784	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
681645003785	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
681645003786	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
681645003787	TIGR03085 family protein; Region: TIGR03085
681645003788	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
681645003789	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
681645003790	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
681645003791	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
681645003792	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
681645003793	dimer interface [polypeptide binding]; other site
681645003794	active site
681645003795	catalytic residue [active]
681645003796	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
681645003797	dihydrodipicolinate reductase; Provisional; Region: PRK00048
681645003798	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
681645003799	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
681645003800	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
681645003801	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
681645003802	oligomer interface [polypeptide binding]; other site
681645003803	RNA binding site [nucleotide binding]; other site
681645003804	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
681645003805	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
681645003806	RNase E interface [polypeptide binding]; other site
681645003807	trimer interface [polypeptide binding]; other site
681645003808	active site
681645003809	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
681645003810	putative nucleic acid binding region [nucleotide binding]; other site
681645003811	G-X-X-G motif; other site
681645003812	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
681645003813	RNA binding site [nucleotide binding]; other site
681645003814	domain interface; other site
681645003815	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
681645003816	16S/18S rRNA binding site [nucleotide binding]; other site
681645003817	S13e-L30e interaction site [polypeptide binding]; other site
681645003818	25S rRNA binding site [nucleotide binding]; other site
681645003819	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
681645003820	active site
681645003821	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
681645003822	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
681645003823	active site
681645003824	Riboflavin kinase; Region: Flavokinase; smart00904
681645003825	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
681645003826	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
681645003827	RNA binding site [nucleotide binding]; other site
681645003828	active site
681645003829	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
681645003830	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
681645003831	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
681645003832	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
681645003833	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
681645003834	active site
681645003835	metal binding site [ion binding]; metal-binding site
681645003836	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
681645003837	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
681645003838	DHH family; Region: DHH; pfam01368
681645003839	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
681645003840	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
681645003841	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
681645003842	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
681645003843	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
681645003844	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
681645003845	G1 box; other site
681645003846	putative GEF interaction site [polypeptide binding]; other site
681645003847	GTP/Mg2+ binding site [chemical binding]; other site
681645003848	Switch I region; other site
681645003849	G2 box; other site
681645003850	G3 box; other site
681645003851	Switch II region; other site
681645003852	G4 box; other site
681645003853	G5 box; other site
681645003854	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
681645003855	Translation-initiation factor 2; Region: IF-2; pfam11987
681645003856	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
681645003857	Protein of unknown function (DUF448); Region: DUF448; pfam04296
681645003858	putative RNA binding cleft [nucleotide binding]; other site
681645003859	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
681645003860	NusA N-terminal domain; Region: NusA_N; pfam08529
681645003861	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
681645003862	RNA binding site [nucleotide binding]; other site
681645003863	homodimer interface [polypeptide binding]; other site
681645003864	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
681645003865	G-X-X-G motif; other site
681645003866	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
681645003867	G-X-X-G motif; other site
681645003868	ribosome maturation protein RimP; Reviewed; Region: PRK00092
681645003869	Sm and related proteins; Region: Sm_like; cl00259
681645003870	prolyl-tRNA synthetase; Provisional; Region: PRK09194
681645003871	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
681645003872	dimer interface [polypeptide binding]; other site
681645003873	motif 1; other site
681645003874	active site
681645003875	motif 2; other site
681645003876	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
681645003877	putative deacylase active site [active]
681645003878	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
681645003879	active site
681645003880	motif 3; other site
681645003881	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
681645003882	anticodon binding site; other site
681645003883	hypothetical protein; Validated; Region: PRK02101
681645003884	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
681645003885	active site
681645003886	SAM binding site [chemical binding]; other site
681645003887	homodimer interface [polypeptide binding]; other site
681645003888	hypothetical protein; Validated; Region: PRK00029
681645003889	Uncharacterized conserved protein [Function unknown]; Region: COG0397
681645003890	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
681645003891	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
681645003892	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
681645003893	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
681645003894	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
681645003895	DNA binding site [nucleotide binding]
681645003896	active site
681645003897	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
681645003898	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
681645003899	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
681645003900	catalytic triad [active]
681645003901	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
681645003902	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
681645003903	homodimer interface [polypeptide binding]; other site
681645003904	Walker A motif; other site
681645003905	ATP binding site [chemical binding]; other site
681645003906	hydroxycobalamin binding site [chemical binding]; other site
681645003907	Walker B motif; other site
681645003908	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
681645003909	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
681645003910	metal ion-dependent adhesion site (MIDAS); other site
681645003911	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
681645003912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645003913	Walker A motif; other site
681645003914	ATP binding site [chemical binding]; other site
681645003915	Walker B motif; other site
681645003916	arginine finger; other site
681645003917	malate:quinone oxidoreductase; Validated; Region: PRK05257
681645003918	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
681645003919	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
681645003920	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
681645003921	mycothione reductase; Reviewed; Region: PRK07846
681645003922	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
681645003923	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
681645003924	cobyric acid synthase; Provisional; Region: PRK00784
681645003925	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
681645003926	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
681645003927	catalytic triad [active]
681645003928	methionine aminopeptidase; Provisional; Region: PRK12318
681645003929	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
681645003930	active site
681645003931	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
681645003932	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
681645003933	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
681645003934	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
681645003935	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
681645003936	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
681645003937	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
681645003938	active site
681645003939	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
681645003940	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
681645003941	putative substrate binding region [chemical binding]; other site
681645003942	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
681645003943	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
681645003944	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
681645003945	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
681645003946	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
681645003947	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
681645003948	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
681645003949	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
681645003950	ribosome recycling factor; Reviewed; Region: frr; PRK00083
681645003951	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
681645003952	hinge region; other site
681645003953	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
681645003954	putative nucleotide binding site [chemical binding]; other site
681645003955	uridine monophosphate binding site [chemical binding]; other site
681645003956	homohexameric interface [polypeptide binding]; other site
681645003957	elongation factor Ts; Provisional; Region: tsf; PRK09377
681645003958	UBA/TS-N domain; Region: UBA; pfam00627
681645003959	Elongation factor TS; Region: EF_TS; pfam00889
681645003960	Elongation factor TS; Region: EF_TS; pfam00889
681645003961	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
681645003962	rRNA interaction site [nucleotide binding]; other site
681645003963	S8 interaction site; other site
681645003964	putative laminin-1 binding site; other site
681645003965	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
681645003966	Peptidase family M23; Region: Peptidase_M23; pfam01551
681645003967	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
681645003968	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
681645003969	active site
681645003970	DNA binding site [nucleotide binding]
681645003971	Int/Topo IB signature motif; other site
681645003972	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
681645003973	DNA protecting protein DprA; Region: dprA; TIGR00732
681645003974	hypothetical protein; Reviewed; Region: PRK12497
681645003975	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
681645003976	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
681645003977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645003978	Walker A motif; other site
681645003979	ATP binding site [chemical binding]; other site
681645003980	Walker B motif; other site
681645003981	arginine finger; other site
681645003982	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
681645003983	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
681645003984	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
681645003985	RNA/DNA hybrid binding site [nucleotide binding]; other site
681645003986	active site
681645003987	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
681645003988	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
681645003989	Catalytic site [active]
681645003990	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
681645003991	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
681645003992	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
681645003993	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
681645003994	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
681645003995	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
681645003996	RNA binding site [nucleotide binding]; other site
681645003997	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
681645003998	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
681645003999	active site
681645004000	P-loop; other site
681645004001	phosphorylation site [posttranslational modification]
681645004002	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
681645004003	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
681645004004	active site
681645004005	phosphorylation site [posttranslational modification]
681645004006	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
681645004007	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
681645004008	RimM N-terminal domain; Region: RimM; pfam01782
681645004009	PRC-barrel domain; Region: PRC; pfam05239
681645004010	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
681645004011	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
681645004012	signal recognition particle protein; Provisional; Region: PRK10867
681645004013	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
681645004014	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
681645004015	P loop; other site
681645004016	GTP binding site [chemical binding]; other site
681645004017	Signal peptide binding domain; Region: SRP_SPB; pfam02978
681645004018	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
681645004019	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
681645004020	metal binding triad; other site
681645004021	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
681645004022	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
681645004023	Zn2+ binding site [ion binding]; other site
681645004024	Mg2+ binding site [ion binding]; other site
681645004025	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
681645004026	Nitrogen regulatory protein P-II; Region: P-II; smart00938
681645004027	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
681645004028	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
681645004029	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
681645004030	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
681645004031	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
681645004032	Walker A/P-loop; other site
681645004033	ATP binding site [chemical binding]; other site
681645004034	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
681645004035	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
681645004036	ABC transporter signature motif; other site
681645004037	Walker B; other site
681645004038	D-loop; other site
681645004039	H-loop/switch region; other site
681645004040	Acylphosphatase; Region: Acylphosphatase; cl00551
681645004041	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
681645004042	amino acid carrier protein; Region: agcS; TIGR00835
681645004043	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
681645004044	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
681645004045	DNA binding site [nucleotide binding]
681645004046	catalytic residue [active]
681645004047	H2TH interface [polypeptide binding]; other site
681645004048	putative catalytic residues [active]
681645004049	turnover-facilitating residue; other site
681645004050	intercalation triad [nucleotide binding]; other site
681645004051	8OG recognition residue [nucleotide binding]; other site
681645004052	putative reading head residues; other site
681645004053	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
681645004054	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
681645004055	ribonuclease III; Reviewed; Region: rnc; PRK00102
681645004056	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
681645004057	dimerization interface [polypeptide binding]; other site
681645004058	active site
681645004059	metal binding site [ion binding]; metal-binding site
681645004060	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
681645004061	dsRNA binding site [nucleotide binding]; other site
681645004062	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
681645004063	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
681645004064	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
681645004065	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
681645004066	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
681645004067	hexamer interface [polypeptide binding]; other site
681645004068	ligand binding site [chemical binding]; other site
681645004069	putative active site [active]
681645004070	NAD(P) binding site [chemical binding]; other site
681645004071	glutamate dehydrogenase; Provisional; Region: PRK09414
681645004072	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
681645004073	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
681645004074	NAD(P) binding site [chemical binding]; other site
681645004075	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
681645004076	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
681645004077	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
681645004078	nucleotide binding site/active site [active]
681645004079	HIT family signature motif; other site
681645004080	catalytic residue [active]
681645004081	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
681645004082	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
681645004083	metal binding site [ion binding]; metal-binding site
681645004084	putative dimer interface [polypeptide binding]; other site
681645004085	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
681645004086	homodimer interface [polypeptide binding]; other site
681645004087	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
681645004088	active site pocket [active]
681645004089	Electron transfer DM13; Region: DM13; pfam10517
681645004090	pyruvate kinase; Provisional; Region: PRK06247
681645004091	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
681645004092	domain interfaces; other site
681645004093	active site
681645004094	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
681645004095	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
681645004096	active site
681645004097	ribulose/triose binding site [chemical binding]; other site
681645004098	phosphate binding site [ion binding]; other site
681645004099	substrate (anthranilate) binding pocket [chemical binding]; other site
681645004100	product (indole) binding pocket [chemical binding]; other site
681645004101	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
681645004102	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
681645004103	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
681645004104	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
681645004105	substrate binding site [chemical binding]; other site
681645004106	glutamase interaction surface [polypeptide binding]; other site
681645004107	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
681645004108	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
681645004109	active site
681645004110	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
681645004111	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
681645004112	catalytic residues [active]
681645004113	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
681645004114	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
681645004115	putative active site [active]
681645004116	oxyanion strand; other site
681645004117	catalytic triad [active]
681645004118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645004119	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645004120	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
681645004121	putative active site pocket [active]
681645004122	4-fold oligomerization interface [polypeptide binding]; other site
681645004123	metal binding residues [ion binding]; metal-binding site
681645004124	3-fold/trimer interface [polypeptide binding]; other site
681645004125	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
681645004126	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645004127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645004128	homodimer interface [polypeptide binding]; other site
681645004129	catalytic residue [active]
681645004130	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
681645004131	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
681645004132	NAD binding site [chemical binding]; other site
681645004133	dimerization interface [polypeptide binding]; other site
681645004134	product binding site; other site
681645004135	substrate binding site [chemical binding]; other site
681645004136	zinc binding site [ion binding]; other site
681645004137	catalytic residues [active]
681645004138	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
681645004139	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
681645004140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645004141	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
681645004142	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
681645004143	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
681645004144	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
681645004145	active site
681645004146	catalytic site [active]
681645004147	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
681645004148	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
681645004149	active site
681645004150	catalytic site [active]
681645004151	substrate binding site [chemical binding]; other site
681645004152	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
681645004153	Dimer interface [polypeptide binding]; other site
681645004154	BRCT sequence motif; other site
681645004155	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
681645004156	synthetase active site [active]
681645004157	NTP binding site [chemical binding]; other site
681645004158	metal binding site [ion binding]; metal-binding site
681645004159	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
681645004160	RNA binding surface [nucleotide binding]; other site
681645004161	Uncharacterized conserved protein [Function unknown]; Region: COG1739
681645004162	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
681645004163	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
681645004164	threonine dehydratase; Validated; Region: PRK08639
681645004165	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
681645004166	tetramer interface [polypeptide binding]; other site
681645004167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645004168	catalytic residue [active]
681645004169	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
681645004170	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
681645004171	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
681645004172	active site
681645004173	PHP Thumb interface [polypeptide binding]; other site
681645004174	metal binding site [ion binding]; metal-binding site
681645004175	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
681645004176	generic binding surface I; other site
681645004177	generic binding surface II; other site
681645004178	Predicted permeases [General function prediction only]; Region: RarD; COG2962
681645004179	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
681645004180	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
681645004181	RNA binding surface [nucleotide binding]; other site
681645004182	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
681645004183	active site
681645004184	lipoprotein signal peptidase; Provisional; Region: PRK14764
681645004185	lipoprotein signal peptidase; Provisional; Region: PRK14787
681645004186	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
681645004187	active site
681645004188	homotetramer interface [polypeptide binding]; other site
681645004189	homodimer interface [polypeptide binding]; other site
681645004190	DNA polymerase IV; Provisional; Region: PRK03348
681645004191	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
681645004192	active site
681645004193	DNA binding site [nucleotide binding]
681645004194	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
681645004195	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
681645004196	HIGH motif; other site
681645004197	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
681645004198	active site
681645004199	KMSKS motif; other site
681645004200	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
681645004201	tRNA binding surface [nucleotide binding]; other site
681645004202	anticodon binding site; other site
681645004203	DivIVA protein; Region: DivIVA; pfam05103
681645004204	DivIVA domain; Region: DivI1A_domain; TIGR03544
681645004205	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
681645004206	YGGT family; Region: YGGT; pfam02325
681645004207	Protein of unknown function (DUF552); Region: DUF552; cl00775
681645004208	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
681645004209	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
681645004210	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
681645004211	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
681645004212	nucleotide binding site [chemical binding]; other site
681645004213	SulA interaction site; other site
681645004214	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
681645004215	Cell division protein FtsQ; Region: FtsQ; pfam03799
681645004216	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
681645004217	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
681645004218	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645004219	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
681645004220	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
681645004221	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
681645004222	homodimer interface [polypeptide binding]; other site
681645004223	active site
681645004224	cell division protein FtsW; Region: ftsW; TIGR02614
681645004225	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
681645004226	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645004227	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
681645004228	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
681645004229	Mg++ binding site [ion binding]; other site
681645004230	putative catalytic motif [active]
681645004231	putative substrate binding site [chemical binding]; other site
681645004232	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
681645004233	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
681645004234	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645004235	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
681645004236	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
681645004237	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
681645004238	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645004239	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
681645004240	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
681645004241	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
681645004242	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
681645004243	MraW methylase family; Region: Methyltransf_5; cl17771
681645004244	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
681645004245	cell division protein MraZ; Reviewed; Region: PRK00326
681645004246	MraZ protein; Region: MraZ; pfam02381
681645004247	MraZ protein; Region: MraZ; pfam02381
681645004248	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
681645004249	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
681645004250	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
681645004251	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
681645004252	FAD binding site [chemical binding]; other site
681645004253	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
681645004254	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
681645004255	substrate binding pocket [chemical binding]; other site
681645004256	chain length determination region; other site
681645004257	substrate-Mg2+ binding site; other site
681645004258	catalytic residues [active]
681645004259	aspartate-rich region 1; other site
681645004260	active site lid residues [active]
681645004261	aspartate-rich region 2; other site
681645004262	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
681645004263	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
681645004264	Catalytic domain of Protein Kinases; Region: PKc; cd00180
681645004265	active site
681645004266	ATP binding site [chemical binding]; other site
681645004267	substrate binding site [chemical binding]; other site
681645004268	activation loop (A-loop); other site
681645004269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
681645004270	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645004271	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645004272	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645004273	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
681645004274	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
681645004275	Predicted membrane protein [Function unknown]; Region: COG4763
681645004276	Acyltransferase family; Region: Acyl_transf_3; pfam01757
681645004277	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
681645004278	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
681645004279	putative acyl-acceptor binding pocket; other site
681645004280	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
681645004281	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
681645004282	nucleotide binding site [chemical binding]; other site
681645004283	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
681645004284	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
681645004285	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
681645004286	NlpC/P60 family; Region: NLPC_P60; pfam00877
681645004287	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
681645004288	NlpC/P60 family; Region: NLPC_P60; pfam00877
681645004289	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
681645004290	heme bH binding site [chemical binding]; other site
681645004291	intrachain domain interface; other site
681645004292	heme bL binding site [chemical binding]; other site
681645004293	interchain domain interface [polypeptide binding]; other site
681645004294	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
681645004295	Qo binding site; other site
681645004296	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
681645004297	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
681645004298	iron-sulfur cluster [ion binding]; other site
681645004299	[2Fe-2S] cluster binding site [ion binding]; other site
681645004300	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
681645004301	Cytochrome c; Region: Cytochrom_C; pfam00034
681645004302	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
681645004303	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
681645004304	Subunit I/III interface [polypeptide binding]; other site
681645004305	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
681645004306	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
681645004307	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
681645004308	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
681645004309	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
681645004310	active site
681645004311	dimer interface [polypeptide binding]; other site
681645004312	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
681645004313	Ligand Binding Site [chemical binding]; other site
681645004314	Molecular Tunnel; other site
681645004315	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
681645004316	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
681645004317	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
681645004318	homotrimer interface [polypeptide binding]; other site
681645004319	Walker A motif; other site
681645004320	GTP binding site [chemical binding]; other site
681645004321	Walker B motif; other site
681645004322	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
681645004323	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
681645004324	putative dimer interface [polypeptide binding]; other site
681645004325	active site pocket [active]
681645004326	putative cataytic base [active]
681645004327	cobalamin synthase; Reviewed; Region: cobS; PRK00235
681645004328	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
681645004329	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
681645004330	homodimer interface [polypeptide binding]; other site
681645004331	substrate-cofactor binding pocket; other site
681645004332	catalytic residue [active]
681645004333	multifunctional aminopeptidase A; Provisional; Region: PRK00913
681645004334	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
681645004335	interface (dimer of trimers) [polypeptide binding]; other site
681645004336	Substrate-binding/catalytic site; other site
681645004337	Zn-binding sites [ion binding]; other site
681645004338	glycine dehydrogenase; Provisional; Region: PRK05367
681645004339	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
681645004340	tetramer interface [polypeptide binding]; other site
681645004341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645004342	catalytic residue [active]
681645004343	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
681645004344	tetramer interface [polypeptide binding]; other site
681645004345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645004346	catalytic residue [active]
681645004347	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
681645004348	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
681645004349	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
681645004350	lipoyl attachment site [posttranslational modification]; other site
681645004351	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
681645004352	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
681645004353	active site
681645004354	lipoate-protein ligase B; Provisional; Region: PRK14345
681645004355	lipoyl synthase; Provisional; Region: PRK05481
681645004356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645004357	FeS/SAM binding site; other site
681645004358	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
681645004359	RDD family; Region: RDD; pfam06271
681645004360	glutamine synthetase, type I; Region: GlnA; TIGR00653
681645004361	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
681645004362	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
681645004363	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
681645004364	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
681645004365	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
681645004366	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
681645004367	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
681645004368	DNA methylase; Region: N6_N4_Mtase; pfam01555
681645004369	DNA methylase; Region: N6_N4_Mtase; cl17433
681645004370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645004371	AAA domain; Region: AAA_21; pfam13304
681645004372	Walker A/P-loop; other site
681645004373	ATP binding site [chemical binding]; other site
681645004374	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
681645004375	putative active site [active]
681645004376	putative metal-binding site [ion binding]; other site
681645004377	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
681645004378	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
681645004379	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
681645004380	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
681645004381	HsdM N-terminal domain; Region: HsdM_N; pfam12161
681645004382	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
681645004383	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
681645004384	Walker A/P-loop; other site
681645004385	ATP binding site [chemical binding]; other site
681645004386	Q-loop/lid; other site
681645004387	ABC transporter signature motif; other site
681645004388	Walker B; other site
681645004389	D-loop; other site
681645004390	H-loop/switch region; other site
681645004391	Htaa; Region: HtaA; pfam04213
681645004392	Htaa; Region: HtaA; pfam04213
681645004393	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
681645004394	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
681645004395	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
681645004396	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
681645004397	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
681645004398	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
681645004399	active site
681645004400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
681645004401	Predicted permease [General function prediction only]; Region: COG2056
681645004402	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
681645004403	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
681645004404	nudix motif; other site
681645004405	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
681645004406	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
681645004407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645004408	catalytic residue [active]
681645004409	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
681645004410	active site
681645004411	catalytic site [active]
681645004412	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
681645004413	heme binding pocket [chemical binding]; other site
681645004414	heme ligand [chemical binding]; other site
681645004415	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
681645004416	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
681645004417	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
681645004418	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
681645004419	putative active site; other site
681645004420	putative metal binding residues [ion binding]; other site
681645004421	signature motif; other site
681645004422	putative triphosphate binding site [ion binding]; other site
681645004423	CHAD domain; Region: CHAD; pfam05235
681645004424	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
681645004425	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
681645004426	RNB domain; Region: RNB; pfam00773
681645004427	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
681645004428	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
681645004429	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
681645004430	RNA/DNA hybrid binding site [nucleotide binding]; other site
681645004431	active site
681645004432	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645004433	catalytic core [active]
681645004434	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
681645004435	Putative zinc ribbon domain; Region: DUF164; pfam02591
681645004436	Uncharacterized conserved protein [Function unknown]; Region: COG0327
681645004437	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
681645004438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
681645004439	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
681645004440	hypothetical protein; Provisional; Region: PRK07908
681645004441	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645004442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645004443	homodimer interface [polypeptide binding]; other site
681645004444	catalytic residue [active]
681645004445	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
681645004446	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645004447	motif II; other site
681645004448	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
681645004449	Low molecular weight phosphatase family; Region: LMWPc; cd00115
681645004450	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
681645004451	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
681645004452	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
681645004453	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
681645004454	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
681645004455	dimer interface [polypeptide binding]; other site
681645004456	TPP-binding site [chemical binding]; other site
681645004457	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
681645004458	Serine hydrolase; Region: Ser_hydrolase; cl17834
681645004459	Phosphopantetheine attachment site; Region: PP-binding; cl09936
681645004460	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
681645004461	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645004462	active site
681645004463	motif I; other site
681645004464	motif II; other site
681645004465	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645004466	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
681645004467	Beta-lactamase; Region: Beta-lactamase; pfam00144
681645004468	Predicted membrane protein [Function unknown]; Region: COG2860
681645004469	UPF0126 domain; Region: UPF0126; pfam03458
681645004470	UPF0126 domain; Region: UPF0126; pfam03458
681645004471	DNA primase; Validated; Region: dnaG; PRK05667
681645004472	CHC2 zinc finger; Region: zf-CHC2; pfam01807
681645004473	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
681645004474	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
681645004475	active site
681645004476	metal binding site [ion binding]; metal-binding site
681645004477	interdomain interaction site; other site
681645004478	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
681645004479	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
681645004480	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
681645004481	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
681645004482	glutaminase active site [active]
681645004483	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
681645004484	dimer interface [polypeptide binding]; other site
681645004485	active site
681645004486	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
681645004487	dimer interface [polypeptide binding]; other site
681645004488	active site
681645004489	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
681645004490	active site
681645004491	barstar interaction site; other site
681645004492	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
681645004493	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
681645004494	Zn2+ binding site [ion binding]; other site
681645004495	Mg2+ binding site [ion binding]; other site
681645004496	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
681645004497	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
681645004498	putative active site [active]
681645004499	Repair protein; Region: Repair_PSII; pfam04536
681645004500	glycyl-tRNA synthetase; Provisional; Region: PRK04173
681645004501	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
681645004502	motif 1; other site
681645004503	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
681645004504	active site
681645004505	motif 2; other site
681645004506	motif 3; other site
681645004507	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
681645004508	anticodon binding site; other site
681645004509	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
681645004510	putative DNA binding site [nucleotide binding]; other site
681645004511	putative Zn2+ binding site [ion binding]; other site
681645004512	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
681645004513	metal binding site 2 [ion binding]; metal-binding site
681645004514	putative DNA binding helix; other site
681645004515	metal binding site 1 [ion binding]; metal-binding site
681645004516	dimer interface [polypeptide binding]; other site
681645004517	structural Zn2+ binding site [ion binding]; other site
681645004518	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
681645004519	diiron binding motif [ion binding]; other site
681645004520	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
681645004521	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
681645004522	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
681645004523	catalytic residue [active]
681645004524	putative FPP diphosphate  binding site; other site
681645004525	putative FPP binding hydrophobic cleft; other site
681645004526	dimer interface [polypeptide binding]; other site
681645004527	putative IPP diphosphate binding site; other site
681645004528	Recombination protein O N terminal; Region: RecO_N; pfam11967
681645004529	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
681645004530	Recombination protein O C terminal; Region: RecO_C; pfam02565
681645004531	GTPase Era; Reviewed; Region: era; PRK00089
681645004532	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
681645004533	G1 box; other site
681645004534	GTP/Mg2+ binding site [chemical binding]; other site
681645004535	Switch I region; other site
681645004536	G2 box; other site
681645004537	Switch II region; other site
681645004538	G3 box; other site
681645004539	G4 box; other site
681645004540	G5 box; other site
681645004541	KH domain; Region: KH_2; pfam07650
681645004542	pyridoxamine kinase; Validated; Region: PRK05756
681645004543	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
681645004544	dimer interface [polypeptide binding]; other site
681645004545	pyridoxal binding site [chemical binding]; other site
681645004546	ATP binding site [chemical binding]; other site
681645004547	Domain of unknown function DUF21; Region: DUF21; pfam01595
681645004548	FOG: CBS domain [General function prediction only]; Region: COG0517
681645004549	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
681645004550	Transporter associated domain; Region: CorC_HlyC; smart01091
681645004551	metal-binding heat shock protein; Provisional; Region: PRK00016
681645004552	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
681645004553	PhoH-like protein; Region: PhoH; pfam02562
681645004554	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
681645004555	RNA methyltransferase, RsmE family; Region: TIGR00046
681645004556	chaperone protein DnaJ; Provisional; Region: PRK14278
681645004557	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
681645004558	HSP70 interaction site [polypeptide binding]; other site
681645004559	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
681645004560	Zn binding sites [ion binding]; other site
681645004561	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
681645004562	dimer interface [polypeptide binding]; other site
681645004563	coproporphyrinogen III oxidase; Validated; Region: PRK05628
681645004564	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
681645004565	FeS/SAM binding site; other site
681645004566	HemN C-terminal domain; Region: HemN_C; pfam06969
681645004567	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
681645004568	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
681645004569	acyl-activating enzyme (AAE) consensus motif; other site
681645004570	putative AMP binding site [chemical binding]; other site
681645004571	putative active site [active]
681645004572	putative CoA binding site [chemical binding]; other site
681645004573	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
681645004574	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
681645004575	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
681645004576	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
681645004577	active site
681645004578	Zn binding site [ion binding]; other site
681645004579	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
681645004580	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
681645004581	substrate binding pocket [chemical binding]; other site
681645004582	catalytic triad [active]
681645004583	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
681645004584	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
681645004585	active site
681645004586	metal binding site [ion binding]; metal-binding site
681645004587	nudix motif; other site
681645004588	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
681645004589	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
681645004590	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
681645004591	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
681645004592	active site
681645004593	BCCT family transporter; Region: BCCT; pfam02028
681645004594	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
681645004595	Predicted permeases [General function prediction only]; Region: COG0679
681645004596	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
681645004597	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
681645004598	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
681645004599	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645004600	dimer interface [polypeptide binding]; other site
681645004601	conserved gate region; other site
681645004602	putative PBP binding loops; other site
681645004603	ABC-ATPase subunit interface; other site
681645004604	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
681645004605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645004606	dimer interface [polypeptide binding]; other site
681645004607	conserved gate region; other site
681645004608	putative PBP binding loops; other site
681645004609	ABC-ATPase subunit interface; other site
681645004610	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
681645004611	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645004612	Walker A/P-loop; other site
681645004613	ATP binding site [chemical binding]; other site
681645004614	Q-loop/lid; other site
681645004615	ABC transporter signature motif; other site
681645004616	Walker B; other site
681645004617	D-loop; other site
681645004618	H-loop/switch region; other site
681645004619	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645004620	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645004621	Walker A/P-loop; other site
681645004622	ATP binding site [chemical binding]; other site
681645004623	Q-loop/lid; other site
681645004624	ABC transporter signature motif; other site
681645004625	Walker B; other site
681645004626	D-loop; other site
681645004627	H-loop/switch region; other site
681645004628	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645004629	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
681645004630	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
681645004631	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
681645004632	catalytic residue [active]
681645004633	Sulphur transport; Region: Sulf_transp; pfam04143
681645004634	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
681645004635	CPxP  motif; other site
681645004636	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645004637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645004638	putative substrate translocation pore; other site
681645004639	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645004640	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
681645004641	Walker A/P-loop; other site
681645004642	ATP binding site [chemical binding]; other site
681645004643	Q-loop/lid; other site
681645004644	ABC transporter signature motif; other site
681645004645	Walker B; other site
681645004646	D-loop; other site
681645004647	H-loop/switch region; other site
681645004648	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
681645004649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645004650	Walker A/P-loop; other site
681645004651	ATP binding site [chemical binding]; other site
681645004652	Q-loop/lid; other site
681645004653	ABC transporter signature motif; other site
681645004654	Walker B; other site
681645004655	D-loop; other site
681645004656	H-loop/switch region; other site
681645004657	GTP-binding protein LepA; Provisional; Region: PRK05433
681645004658	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
681645004659	G1 box; other site
681645004660	putative GEF interaction site [polypeptide binding]; other site
681645004661	GTP/Mg2+ binding site [chemical binding]; other site
681645004662	Switch I region; other site
681645004663	G2 box; other site
681645004664	G3 box; other site
681645004665	Switch II region; other site
681645004666	G4 box; other site
681645004667	G5 box; other site
681645004668	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
681645004669	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
681645004670	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
681645004671	PemK-like protein; Region: PemK; pfam02452
681645004672	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
681645004673	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
681645004674	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
681645004675	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
681645004676	hypothetical protein; Validated; Region: PRK05629
681645004677	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
681645004678	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
681645004679	Competence protein; Region: Competence; pfam03772
681645004680	comEA protein; Region: comE; TIGR01259
681645004681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
681645004682	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
681645004683	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645004684	catalytic core [active]
681645004685	Oligomerisation domain; Region: Oligomerisation; pfam02410
681645004686	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
681645004687	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
681645004688	active site
681645004689	(T/H)XGH motif; other site
681645004690	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
681645004691	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
681645004692	putative catalytic cysteine [active]
681645004693	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
681645004694	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
681645004695	putative ligand binding site [chemical binding]; other site
681645004696	putative NAD binding site [chemical binding]; other site
681645004697	catalytic site [active]
681645004698	Protein of unknown function (DUF454); Region: DUF454; cl01063
681645004699	Predicted permease [General function prediction only]; Region: COG2985
681645004700	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
681645004701	TrkA-C domain; Region: TrkA_C; pfam02080
681645004702	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
681645004703	gamma-glutamyl kinase; Provisional; Region: PRK05429
681645004704	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
681645004705	nucleotide binding site [chemical binding]; other site
681645004706	homotetrameric interface [polypeptide binding]; other site
681645004707	putative phosphate binding site [ion binding]; other site
681645004708	putative allosteric binding site; other site
681645004709	PUA domain; Region: PUA; pfam01472
681645004710	GTPase CgtA; Reviewed; Region: obgE; PRK12296
681645004711	GTP1/OBG; Region: GTP1_OBG; pfam01018
681645004712	Obg GTPase; Region: Obg; cd01898
681645004713	G1 box; other site
681645004714	GTP/Mg2+ binding site [chemical binding]; other site
681645004715	Switch I region; other site
681645004716	G2 box; other site
681645004717	G3 box; other site
681645004718	Switch II region; other site
681645004719	G4 box; other site
681645004720	G5 box; other site
681645004721	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
681645004722	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
681645004723	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
681645004724	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
681645004725	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
681645004726	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
681645004727	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
681645004728	homodimer interface [polypeptide binding]; other site
681645004729	oligonucleotide binding site [chemical binding]; other site
681645004730	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
681645004731	active site
681645004732	multimer interface [polypeptide binding]; other site
681645004733	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
681645004734	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
681645004735	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
681645004736	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
681645004737	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645004738	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
681645004739	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
681645004740	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
681645004741	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645004742	active site
681645004743	HIGH motif; other site
681645004744	nucleotide binding site [chemical binding]; other site
681645004745	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
681645004746	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
681645004747	active site
681645004748	KMSKS motif; other site
681645004749	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
681645004750	tRNA binding surface [nucleotide binding]; other site
681645004751	anticodon binding site; other site
681645004752	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
681645004753	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
681645004754	malate dehydrogenase; Provisional; Region: PRK05442
681645004755	NAD(P) binding site [chemical binding]; other site
681645004756	dimer interface [polypeptide binding]; other site
681645004757	malate binding site [chemical binding]; other site
681645004758	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645004759	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645004760	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
681645004761	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
681645004762	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
681645004763	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645004764	Walker A motif; other site
681645004765	ATP binding site [chemical binding]; other site
681645004766	Walker B motif; other site
681645004767	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
681645004768	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
681645004769	Glutamine amidotransferase class-I; Region: GATase; pfam00117
681645004770	glutamine binding [chemical binding]; other site
681645004771	catalytic triad [active]
681645004772	hypothetical protein; Validated; Region: PRK09070
681645004773	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
681645004774	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
681645004775	Aminotransferase class IV; Region: Aminotran_4; pfam01063
681645004776	substrate-cofactor binding pocket; other site
681645004777	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
681645004778	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
681645004779	oligomer interface [polypeptide binding]; other site
681645004780	active site residues [active]
681645004781	Clp protease; Region: CLP_protease; pfam00574
681645004782	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
681645004783	oligomer interface [polypeptide binding]; other site
681645004784	active site residues [active]
681645004785	trigger factor; Provisional; Region: tig; PRK01490
681645004786	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
681645004787	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
681645004788	Pirin-related protein [General function prediction only]; Region: COG1741
681645004789	Pirin; Region: Pirin; pfam02678
681645004790	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
681645004791	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
681645004792	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
681645004793	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
681645004794	catalytic residues [active]
681645004795	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
681645004796	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
681645004797	Zn binding site [ion binding]; other site
681645004798	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
681645004799	Mechanosensitive ion channel; Region: MS_channel; pfam00924
681645004800	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
681645004801	apolar tunnel; other site
681645004802	heme binding site [chemical binding]; other site
681645004803	dimerization interface [polypeptide binding]; other site
681645004804	Protein of unknown function, DUF606; Region: DUF606; pfam04657
681645004805	Protein of unknown function, DUF606; Region: DUF606; pfam04657
681645004806	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
681645004807	active site
681645004808	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
681645004809	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645004810	Walker A/P-loop; other site
681645004811	ATP binding site [chemical binding]; other site
681645004812	Q-loop/lid; other site
681645004813	ABC transporter signature motif; other site
681645004814	Walker B; other site
681645004815	D-loop; other site
681645004816	H-loop/switch region; other site
681645004817	ABC transporter; Region: ABC_tran_2; pfam12848
681645004818	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
681645004819	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
681645004820	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
681645004821	dimer interface [polypeptide binding]; other site
681645004822	ssDNA binding site [nucleotide binding]; other site
681645004823	tetramer (dimer of dimers) interface [polypeptide binding]; other site
681645004824	YcaO-like family; Region: YcaO; pfam02624
681645004825	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
681645004826	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
681645004827	FMN binding site [chemical binding]; other site
681645004828	dimer interface [polypeptide binding]; other site
681645004829	Nitroreductase family; Region: Nitroreductase; pfam00881
681645004830	dimer interface [polypeptide binding]; other site
681645004831	SpaB C-terminal domain; Region: SpaB_C; pfam14028
681645004832	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
681645004833	YcaO-like family; Region: YcaO; pfam02624
681645004834	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
681645004835	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
681645004836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
681645004837	Walker A/P-loop; other site
681645004838	ATP binding site [chemical binding]; other site
681645004839	Q-loop/lid; other site
681645004840	ABC transporter signature motif; other site
681645004841	Walker B; other site
681645004842	D-loop; other site
681645004843	H-loop/switch region; other site
681645004844	Copper resistance protein D; Region: CopD; pfam05425
681645004845	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
681645004846	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
681645004847	Carbon starvation protein CstA; Region: CstA; pfam02554
681645004848	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
681645004849	Protein of unknown function (DUF466); Region: DUF466; pfam04328
681645004850	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
681645004851	active site
681645004852	catalytic triad [active]
681645004853	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
681645004854	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
681645004855	NADP binding site [chemical binding]; other site
681645004856	dimer interface [polypeptide binding]; other site
681645004857	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
681645004858	classical (c) SDRs; Region: SDR_c; cd05233
681645004859	NAD(P) binding site [chemical binding]; other site
681645004860	active site
681645004861	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
681645004862	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
681645004863	catalytic site [active]
681645004864	putative active site [active]
681645004865	putative substrate binding site [chemical binding]; other site
681645004866	dimer interface [polypeptide binding]; other site
681645004867	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
681645004868	N-acetylneuraminate lyase; Provisional; Region: PRK04147
681645004869	inhibitor site; inhibition site
681645004870	active site
681645004871	dimer interface [polypeptide binding]; other site
681645004872	catalytic residue [active]
681645004873	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
681645004874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
681645004875	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
681645004876	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
681645004877	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
681645004878	Prostaglandin dehydrogenases; Region: PGDH; cd05288
681645004879	NAD(P) binding site [chemical binding]; other site
681645004880	substrate binding site [chemical binding]; other site
681645004881	dimer interface [polypeptide binding]; other site
681645004882	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
681645004883	Isochorismatase family; Region: Isochorismatase; pfam00857
681645004884	catalytic triad [active]
681645004885	metal binding site [ion binding]; metal-binding site
681645004886	conserved cis-peptide bond; other site
681645004887	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
681645004888	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
681645004889	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
681645004890	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
681645004891	catalytic triad [active]
681645004892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645004893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645004894	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
681645004895	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
681645004896	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
681645004897	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
681645004898	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
681645004899	phosphate binding site [ion binding]; other site
681645004900	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
681645004901	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
681645004902	active site 2 [active]
681645004903	active site 1 [active]
681645004904	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
681645004905	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
681645004906	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
681645004907	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
681645004908	putative NAD(P) binding site [chemical binding]; other site
681645004909	active site
681645004910	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
681645004911	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
681645004912	active site
681645004913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
681645004914	Histidine kinase; Region: HisKA_3; pfam07730
681645004915	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
681645004916	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
681645004917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645004918	active site
681645004919	phosphorylation site [posttranslational modification]
681645004920	intermolecular recognition site; other site
681645004921	dimerization interface [polypeptide binding]; other site
681645004922	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
681645004923	DNA binding residues [nucleotide binding]
681645004924	dimerization interface [polypeptide binding]; other site
681645004925	Protein of unknown function (DUF418); Region: DUF418; pfam04235
681645004926	CAAX protease self-immunity; Region: Abi; pfam02517
681645004927	Glucitol operon activator protein (GutM); Region: GutM; cl01890
681645004928	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
681645004929	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
681645004930	active site
681645004931	dimerization interface [polypeptide binding]; other site
681645004932	ribonuclease PH; Reviewed; Region: rph; PRK00173
681645004933	Ribonuclease PH; Region: RNase_PH_bact; cd11362
681645004934	hexamer interface [polypeptide binding]; other site
681645004935	active site
681645004936	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
681645004937	glutamate racemase; Provisional; Region: PRK00865
681645004938	Rhomboid family; Region: Rhomboid; pfam01694
681645004939	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
681645004940	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
681645004941	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
681645004942	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
681645004943	active site
681645004944	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
681645004945	DEAD/DEAH box helicase; Region: DEAD; pfam00270
681645004946	ATP binding site [chemical binding]; other site
681645004947	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
681645004948	putative Mg++ binding site [ion binding]; other site
681645004949	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
681645004950	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
681645004951	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
681645004952	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
681645004953	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
681645004954	phosphoserine phosphatase SerB; Region: serB; TIGR00338
681645004955	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645004956	motif II; other site
681645004957	Winged helix-turn helix; Region: HTH_29; pfam13551
681645004958	Helix-turn-helix domain; Region: HTH_28; pfam13518
681645004959	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
681645004960	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
681645004961	D-pathway; other site
681645004962	Putative ubiquinol binding site [chemical binding]; other site
681645004963	Low-spin heme (heme b) binding site [chemical binding]; other site
681645004964	Putative water exit pathway; other site
681645004965	Binuclear center (heme o3/CuB) [ion binding]; other site
681645004966	K-pathway; other site
681645004967	Putative proton exit pathway; other site
681645004968	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
681645004969	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
681645004970	dimer interface [polypeptide binding]; other site
681645004971	putative radical transfer pathway; other site
681645004972	diiron center [ion binding]; other site
681645004973	tyrosyl radical; other site
681645004974	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
681645004975	Ferritin-like domain; Region: Ferritin; pfam00210
681645004976	ferroxidase diiron center [ion binding]; other site
681645004977	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
681645004978	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
681645004979	Class I ribonucleotide reductase; Region: RNR_I; cd01679
681645004980	active site
681645004981	dimer interface [polypeptide binding]; other site
681645004982	catalytic residues [active]
681645004983	effector binding site; other site
681645004984	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
681645004985	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
681645004986	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
681645004987	catalytic residues [active]
681645004988	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
681645004989	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
681645004990	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
681645004991	homodimer interface [polypeptide binding]; other site
681645004992	NAD binding pocket [chemical binding]; other site
681645004993	ATP binding pocket [chemical binding]; other site
681645004994	Mg binding site [ion binding]; other site
681645004995	active-site loop [active]
681645004996	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
681645004997	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
681645004998	dimerization interface [polypeptide binding]; other site
681645004999	putative DNA binding site [nucleotide binding]; other site
681645005000	putative Zn2+ binding site [ion binding]; other site
681645005001	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
681645005002	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
681645005003	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
681645005004	hinge; other site
681645005005	active site
681645005006	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
681645005007	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
681645005008	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
681645005009	DNA binding residues [nucleotide binding]
681645005010	dimerization interface [polypeptide binding]; other site
681645005011	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
681645005012	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
681645005013	dimer interface [polypeptide binding]; other site
681645005014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645005015	catalytic residue [active]
681645005016	serine O-acetyltransferase; Region: cysE; TIGR01172
681645005017	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
681645005018	trimer interface [polypeptide binding]; other site
681645005019	active site
681645005020	substrate binding site [chemical binding]; other site
681645005021	CoA binding site [chemical binding]; other site
681645005022	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645005023	Coenzyme A binding pocket [chemical binding]; other site
681645005024	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
681645005025	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
681645005026	putative active site [active]
681645005027	metal binding site [ion binding]; metal-binding site
681645005028	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
681645005029	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
681645005030	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
681645005031	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
681645005032	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
681645005033	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645005034	Walker A/P-loop; other site
681645005035	ATP binding site [chemical binding]; other site
681645005036	Q-loop/lid; other site
681645005037	ABC transporter signature motif; other site
681645005038	Walker B; other site
681645005039	D-loop; other site
681645005040	H-loop/switch region; other site
681645005041	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
681645005042	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645005043	Walker A/P-loop; other site
681645005044	ATP binding site [chemical binding]; other site
681645005045	Q-loop/lid; other site
681645005046	ABC transporter signature motif; other site
681645005047	Walker B; other site
681645005048	D-loop; other site
681645005049	H-loop/switch region; other site
681645005050	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
681645005051	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
681645005052	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
681645005053	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
681645005054	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
681645005055	FMN binding site [chemical binding]; other site
681645005056	active site
681645005057	catalytic residues [active]
681645005058	substrate binding site [chemical binding]; other site
681645005059	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
681645005060	PhoU domain; Region: PhoU; pfam01895
681645005061	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
681645005062	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
681645005063	Walker A/P-loop; other site
681645005064	ATP binding site [chemical binding]; other site
681645005065	Q-loop/lid; other site
681645005066	ABC transporter signature motif; other site
681645005067	Walker B; other site
681645005068	D-loop; other site
681645005069	H-loop/switch region; other site
681645005070	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
681645005071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645005072	dimer interface [polypeptide binding]; other site
681645005073	conserved gate region; other site
681645005074	putative PBP binding loops; other site
681645005075	ABC-ATPase subunit interface; other site
681645005076	PBP superfamily domain; Region: PBP_like_2; cl17296
681645005077	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
681645005078	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645005079	Coenzyme A binding pocket [chemical binding]; other site
681645005080	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
681645005081	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
681645005082	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
681645005083	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
681645005084	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
681645005085	heme-binding site [chemical binding]; other site
681645005086	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
681645005087	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
681645005088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645005089	catalytic residue [active]
681645005090	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
681645005091	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
681645005092	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
681645005093	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
681645005094	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
681645005095	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
681645005096	dimerization interface [polypeptide binding]; other site
681645005097	putative ATP binding site [chemical binding]; other site
681645005098	amidophosphoribosyltransferase; Provisional; Region: PRK07847
681645005099	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
681645005100	active site
681645005101	tetramer interface [polypeptide binding]; other site
681645005102	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645005103	active site
681645005104	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
681645005105	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
681645005106	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
681645005107	dimer interface [polypeptide binding]; other site
681645005108	putative radical transfer pathway; other site
681645005109	diiron center [ion binding]; other site
681645005110	tyrosyl radical; other site
681645005111	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
681645005112	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
681645005113	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
681645005114	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
681645005115	dimerization interface [polypeptide binding]; other site
681645005116	ATP binding site [chemical binding]; other site
681645005117	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
681645005118	dimerization interface [polypeptide binding]; other site
681645005119	ATP binding site [chemical binding]; other site
681645005120	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
681645005121	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
681645005122	putative active site [active]
681645005123	catalytic triad [active]
681645005124	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
681645005125	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
681645005126	catalytic residues [active]
681645005127	dimer interface [polypeptide binding]; other site
681645005128	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
681645005129	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
681645005130	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
681645005131	ATP binding site [chemical binding]; other site
681645005132	active site
681645005133	substrate binding site [chemical binding]; other site
681645005134	adenylosuccinate lyase; Region: purB; TIGR00928
681645005135	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
681645005136	tetramer interface [polypeptide binding]; other site
681645005137	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
681645005138	TrkA-N domain; Region: TrkA_N; pfam02254
681645005139	TrkA-C domain; Region: TrkA_C; pfam02080
681645005140	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
681645005141	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
681645005142	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
681645005143	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
681645005144	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
681645005145	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
681645005146	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
681645005147	nucleotide binding site/active site [active]
681645005148	HIT family signature motif; other site
681645005149	catalytic residue [active]
681645005150	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
681645005151	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
681645005152	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
681645005153	dimerization interface [polypeptide binding]; other site
681645005154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
681645005155	dimer interface [polypeptide binding]; other site
681645005156	phosphorylation site [posttranslational modification]
681645005157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645005158	ATP binding site [chemical binding]; other site
681645005159	Mg2+ binding site [ion binding]; other site
681645005160	G-X-G motif; other site
681645005161	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
681645005162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645005163	active site
681645005164	phosphorylation site [posttranslational modification]
681645005165	intermolecular recognition site; other site
681645005166	dimerization interface [polypeptide binding]; other site
681645005167	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
681645005168	DNA binding site [nucleotide binding]
681645005169	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645005170	Predicted esterase [General function prediction only]; Region: COG0627
681645005171	S-formylglutathione hydrolase; Region: PLN02442
681645005172	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
681645005173	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
681645005174	putative active site [active]
681645005175	pyruvate dehydrogenase; Provisional; Region: PRK06546
681645005176	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
681645005177	PYR/PP interface [polypeptide binding]; other site
681645005178	tetramer interface [polypeptide binding]; other site
681645005179	dimer interface [polypeptide binding]; other site
681645005180	TPP binding site [chemical binding]; other site
681645005181	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
681645005182	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
681645005183	TPP-binding site [chemical binding]; other site
681645005184	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
681645005185	Uncharacterized conserved protein [Function unknown]; Region: COG3610
681645005186	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
681645005187	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
681645005188	active site
681645005189	homotetramer interface [polypeptide binding]; other site
681645005190	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
681645005191	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
681645005192	Transcriptional regulators [Transcription]; Region: PurR; COG1609
681645005193	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
681645005194	DNA binding site [nucleotide binding]
681645005195	domain linker motif; other site
681645005196	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
681645005197	putative dimerization interface [polypeptide binding]; other site
681645005198	putative ligand binding site [chemical binding]; other site
681645005199	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
681645005200	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
681645005201	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
681645005202	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
681645005203	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
681645005204	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645005205	active site
681645005206	HIGH motif; other site
681645005207	nucleotide binding site [chemical binding]; other site
681645005208	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
681645005209	KMSKS motif; other site
681645005210	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
681645005211	tRNA binding surface [nucleotide binding]; other site
681645005212	anticodon binding site; other site
681645005213	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
681645005214	homotrimer interaction site [polypeptide binding]; other site
681645005215	zinc binding site [ion binding]; other site
681645005216	CDP-binding sites; other site
681645005217	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
681645005218	substrate binding site; other site
681645005219	dimer interface; other site
681645005220	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
681645005221	DNA repair protein RadA; Provisional; Region: PRK11823
681645005222	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
681645005223	Walker A motif; other site
681645005224	ATP binding site [chemical binding]; other site
681645005225	Walker B motif; other site
681645005226	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
681645005227	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
681645005228	active site clefts [active]
681645005229	zinc binding site [ion binding]; other site
681645005230	dimer interface [polypeptide binding]; other site
681645005231	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
681645005232	endonuclease III; Region: ENDO3c; smart00478
681645005233	minor groove reading motif; other site
681645005234	helix-hairpin-helix signature motif; other site
681645005235	substrate binding pocket [chemical binding]; other site
681645005236	active site
681645005237	Uncharacterized conserved protein [Function unknown]; Region: COG2966
681645005238	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
681645005239	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
681645005240	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
681645005241	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
681645005242	Clp amino terminal domain; Region: Clp_N; pfam02861
681645005243	Clp amino terminal domain; Region: Clp_N; pfam02861
681645005244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645005245	Walker A motif; other site
681645005246	ATP binding site [chemical binding]; other site
681645005247	Walker B motif; other site
681645005248	arginine finger; other site
681645005249	UvrB/uvrC motif; Region: UVR; pfam02151
681645005250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645005251	Walker A motif; other site
681645005252	ATP binding site [chemical binding]; other site
681645005253	Walker B motif; other site
681645005254	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
681645005255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645005256	putative substrate translocation pore; other site
681645005257	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
681645005258	active site
681645005259	tetramer interface [polypeptide binding]; other site
681645005260	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
681645005261	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
681645005262	CAAX protease self-immunity; Region: Abi; pfam02517
681645005263	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
681645005264	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
681645005265	dimer interface [polypeptide binding]; other site
681645005266	putative anticodon binding site; other site
681645005267	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
681645005268	motif 1; other site
681645005269	dimer interface [polypeptide binding]; other site
681645005270	active site
681645005271	motif 2; other site
681645005272	motif 3; other site
681645005273	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
681645005274	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
681645005275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
681645005276	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
681645005277	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
681645005278	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
681645005279	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
681645005280	NAD(P) binding site [chemical binding]; other site
681645005281	catalytic residues [active]
681645005282	choline dehydrogenase; Validated; Region: PRK02106
681645005283	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
681645005284	pantoate--beta-alanine ligase; Region: panC; TIGR00018
681645005285	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645005286	active site
681645005287	nucleotide binding site [chemical binding]; other site
681645005288	HIGH motif; other site
681645005289	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645005290	KMSKS motif; other site
681645005291	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
681645005292	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
681645005293	catalytic center binding site [active]
681645005294	ATP binding site [chemical binding]; other site
681645005295	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
681645005296	homooctamer interface [polypeptide binding]; other site
681645005297	active site
681645005298	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
681645005299	dihydropteroate synthase; Region: DHPS; TIGR01496
681645005300	substrate binding pocket [chemical binding]; other site
681645005301	dimer interface [polypeptide binding]; other site
681645005302	inhibitor binding site; inhibition site
681645005303	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
681645005304	GTP cyclohydrolase I; Provisional; Region: PLN03044
681645005305	homodecamer interface [polypeptide binding]; other site
681645005306	active site
681645005307	putative catalytic site residues [active]
681645005308	zinc binding site [ion binding]; other site
681645005309	GTP-CH-I/GFRP interaction surface; other site
681645005310	FtsH Extracellular; Region: FtsH_ext; pfam06480
681645005311	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
681645005312	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645005313	Walker A motif; other site
681645005314	ATP binding site [chemical binding]; other site
681645005315	Walker B motif; other site
681645005316	arginine finger; other site
681645005317	Peptidase family M41; Region: Peptidase_M41; pfam01434
681645005318	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645005319	active site
681645005320	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
681645005321	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
681645005322	Ligand Binding Site [chemical binding]; other site
681645005323	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
681645005324	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
681645005325	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
681645005326	dimer interface [polypeptide binding]; other site
681645005327	substrate binding site [chemical binding]; other site
681645005328	metal binding sites [ion binding]; metal-binding site
681645005329	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
681645005330	active site residue [active]
681645005331	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
681645005332	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
681645005333	Secretory lipase; Region: LIP; pfam03583
681645005334	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
681645005335	MarR family; Region: MarR_2; pfam12802
681645005336	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
681645005337	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
681645005338	acyl-activating enzyme (AAE) consensus motif; other site
681645005339	AMP binding site [chemical binding]; other site
681645005340	active site
681645005341	CoA binding site [chemical binding]; other site
681645005342	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
681645005343	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
681645005344	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
681645005345	putative trimer interface [polypeptide binding]; other site
681645005346	putative CoA binding site [chemical binding]; other site
681645005347	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
681645005348	putative trimer interface [polypeptide binding]; other site
681645005349	putative CoA binding site [chemical binding]; other site
681645005350	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
681645005351	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
681645005352	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
681645005353	ring oligomerisation interface [polypeptide binding]; other site
681645005354	ATP/Mg binding site [chemical binding]; other site
681645005355	stacking interactions; other site
681645005356	hinge regions; other site
681645005357	hypothetical protein; Provisional; Region: PRK07907
681645005358	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
681645005359	active site
681645005360	metal binding site [ion binding]; metal-binding site
681645005361	dimer interface [polypeptide binding]; other site
681645005362	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
681645005363	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
681645005364	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
681645005365	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
681645005366	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
681645005367	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
681645005368	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
681645005369	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
681645005370	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
681645005371	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
681645005372	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
681645005373	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
681645005374	carboxylate-amine ligase; Provisional; Region: PRK13517
681645005375	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
681645005376	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
681645005377	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
681645005378	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
681645005379	active site
681645005380	catalytic residues [active]
681645005381	metal binding site [ion binding]; metal-binding site
681645005382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
681645005383	Coenzyme A binding pocket [chemical binding]; other site
681645005384	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
681645005385	putative catalytic site [active]
681645005386	putative phosphate binding site [ion binding]; other site
681645005387	active site
681645005388	metal binding site A [ion binding]; metal-binding site
681645005389	DNA binding site [nucleotide binding]
681645005390	putative AP binding site [nucleotide binding]; other site
681645005391	putative metal binding site B [ion binding]; other site
681645005392	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
681645005393	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
681645005394	putative active site [active]
681645005395	catalytic site [active]
681645005396	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
681645005397	putative active site [active]
681645005398	catalytic site [active]
681645005399	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
681645005400	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
681645005401	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
681645005402	Walker A/P-loop; other site
681645005403	ATP binding site [chemical binding]; other site
681645005404	Q-loop/lid; other site
681645005405	ABC transporter signature motif; other site
681645005406	Walker B; other site
681645005407	D-loop; other site
681645005408	H-loop/switch region; other site
681645005409	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
681645005410	nudix motif; other site
681645005411	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
681645005412	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
681645005413	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
681645005414	substrate binding pocket [chemical binding]; other site
681645005415	membrane-bound complex binding site; other site
681645005416	hinge residues; other site
681645005417	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
681645005418	Catalytic domain of Protein Kinases; Region: PKc; cd00180
681645005419	active site
681645005420	ATP binding site [chemical binding]; other site
681645005421	substrate binding site [chemical binding]; other site
681645005422	activation loop (A-loop); other site
681645005423	propionate/acetate kinase; Provisional; Region: PRK12379
681645005424	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
681645005425	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
681645005426	ferredoxin-NADP+ reductase; Region: PLN02852
681645005427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
681645005428	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
681645005429	Coenzyme A binding pocket [chemical binding]; other site
681645005430	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
681645005431	active site
681645005432	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
681645005433	ATP-grasp domain; Region: ATP-grasp_4; cl17255
681645005434	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645005435	active site
681645005436	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
681645005437	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
681645005438	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
681645005439	catalytic residues [active]
681645005440	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
681645005441	ResB-like family; Region: ResB; pfam05140
681645005442	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
681645005443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
681645005444	TPR motif; other site
681645005445	TPR repeat; Region: TPR_11; pfam13414
681645005446	binding surface
681645005447	Cytochrome c552; Region: Cytochrom_C552; pfam02335
681645005448	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
681645005449	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
681645005450	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
681645005451	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
681645005452	GDP-binding site [chemical binding]; other site
681645005453	ACT binding site; other site
681645005454	IMP binding site; other site
681645005455	Predicted membrane protein [Function unknown]; Region: COG4129
681645005456	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
681645005457	Predicted membrane protein [Function unknown]; Region: COG4129
681645005458	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
681645005459	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
681645005460	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
681645005461	Walker A/P-loop; other site
681645005462	ATP binding site [chemical binding]; other site
681645005463	Q-loop/lid; other site
681645005464	ABC transporter signature motif; other site
681645005465	Walker B; other site
681645005466	D-loop; other site
681645005467	H-loop/switch region; other site
681645005468	Predicted transcriptional regulators [Transcription]; Region: COG1695
681645005469	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
681645005470	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
681645005471	Cna protein B-type domain; Region: Cna_B; pfam05738
681645005472	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
681645005473	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
681645005474	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
681645005475	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
681645005476	active site
681645005477	intersubunit interface [polypeptide binding]; other site
681645005478	zinc binding site [ion binding]; other site
681645005479	Na+ binding site [ion binding]; other site
681645005480	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
681645005481	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
681645005482	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
681645005483	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
681645005484	active site
681645005485	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
681645005486	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
681645005487	Gram positive anchor; Region: Gram_pos_anchor; cl15427
681645005488	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
681645005489	active site
681645005490	catalytic site [active]
681645005491	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
681645005492	Cna protein B-type domain; Region: Cna_B; pfam05738
681645005493	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
681645005494	active site
681645005495	catalytic site [active]
681645005496	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
681645005497	Clp amino terminal domain; Region: Clp_N; pfam02861
681645005498	Clp amino terminal domain; Region: Clp_N; pfam02861
681645005499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645005500	Walker A motif; other site
681645005501	ATP binding site [chemical binding]; other site
681645005502	Walker B motif; other site
681645005503	arginine finger; other site
681645005504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
681645005505	Walker A motif; other site
681645005506	ATP binding site [chemical binding]; other site
681645005507	Walker B motif; other site
681645005508	arginine finger; other site
681645005509	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
681645005510	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
681645005511	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
681645005512	Walker A/P-loop; other site
681645005513	ATP binding site [chemical binding]; other site
681645005514	Q-loop/lid; other site
681645005515	ABC transporter signature motif; other site
681645005516	Walker B; other site
681645005517	D-loop; other site
681645005518	H-loop/switch region; other site
681645005519	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
681645005520	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
681645005521	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
681645005522	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
681645005523	FAD binding pocket [chemical binding]; other site
681645005524	conserved FAD binding motif [chemical binding]; other site
681645005525	phosphate binding motif [ion binding]; other site
681645005526	beta-alpha-beta structure motif; other site
681645005527	NAD binding pocket [chemical binding]; other site
681645005528	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
681645005529	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
681645005530	FtsX-like permease family; Region: FtsX; pfam02687
681645005531	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
681645005532	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
681645005533	Walker A/P-loop; other site
681645005534	ATP binding site [chemical binding]; other site
681645005535	Q-loop/lid; other site
681645005536	ABC transporter signature motif; other site
681645005537	Walker B; other site
681645005538	D-loop; other site
681645005539	H-loop/switch region; other site
681645005540	HlyD family secretion protein; Region: HlyD_3; pfam13437
681645005541	Predicted amidohydrolase [General function prediction only]; Region: COG0388
681645005542	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
681645005543	putative active site [active]
681645005544	catalytic triad [active]
681645005545	putative dimer interface [polypeptide binding]; other site
681645005546	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
681645005547	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
681645005548	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
681645005549	NAD binding site [chemical binding]; other site
681645005550	substrate binding site [chemical binding]; other site
681645005551	catalytic Zn binding site [ion binding]; other site
681645005552	tetramer interface [polypeptide binding]; other site
681645005553	structural Zn binding site [ion binding]; other site
681645005554	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
681645005555	active site
681645005556	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
681645005557	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
681645005558	DNA binding residues [nucleotide binding]
681645005559	chaperone protein DnaJ; Provisional; Region: PRK14279
681645005560	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
681645005561	HSP70 interaction site [polypeptide binding]; other site
681645005562	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
681645005563	Zn binding sites [ion binding]; other site
681645005564	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
681645005565	dimer interface [polypeptide binding]; other site
681645005566	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
681645005567	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
681645005568	dimer interface [polypeptide binding]; other site
681645005569	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
681645005570	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
681645005571	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
681645005572	nucleotide binding site [chemical binding]; other site
681645005573	NEF interaction site [polypeptide binding]; other site
681645005574	SBD interface [polypeptide binding]; other site
681645005575	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
681645005576	active site
681645005577	catalytic site [active]
681645005578	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
681645005579	Domain of unknown function DUF20; Region: UPF0118; pfam01594
681645005580	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645005581	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
681645005582	Walker A/P-loop; other site
681645005583	ATP binding site [chemical binding]; other site
681645005584	Q-loop/lid; other site
681645005585	ABC transporter signature motif; other site
681645005586	Walker B; other site
681645005587	D-loop; other site
681645005588	H-loop/switch region; other site
681645005589	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
681645005590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645005591	putative PBP binding loops; other site
681645005592	dimer interface [polypeptide binding]; other site
681645005593	ABC-ATPase subunit interface; other site
681645005594	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
681645005595	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645005596	Walker A/P-loop; other site
681645005597	ATP binding site [chemical binding]; other site
681645005598	Q-loop/lid; other site
681645005599	ABC transporter signature motif; other site
681645005600	Walker B; other site
681645005601	D-loop; other site
681645005602	H-loop/switch region; other site
681645005603	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645005604	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
681645005605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645005606	dimer interface [polypeptide binding]; other site
681645005607	conserved gate region; other site
681645005608	putative PBP binding loops; other site
681645005609	ABC-ATPase subunit interface; other site
681645005610	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
681645005611	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
681645005612	adrenodoxin reductase; Provisional; Region: PTZ00188
681645005613	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
681645005614	4Fe-4S binding domain; Region: Fer4; cl02805
681645005615	4Fe-4S binding domain; Region: Fer4; pfam00037
681645005616	Cysteine-rich domain; Region: CCG; pfam02754
681645005617	Cysteine-rich domain; Region: CCG; pfam02754
681645005618	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
681645005619	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
681645005620	dimerization interface [polypeptide binding]; other site
681645005621	putative DNA binding site [nucleotide binding]; other site
681645005622	putative Zn2+ binding site [ion binding]; other site
681645005623	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645005624	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645005625	Walker A/P-loop; other site
681645005626	ATP binding site [chemical binding]; other site
681645005627	Q-loop/lid; other site
681645005628	ABC transporter signature motif; other site
681645005629	Walker B; other site
681645005630	D-loop; other site
681645005631	H-loop/switch region; other site
681645005632	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
681645005633	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645005634	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645005635	putative PBP binding regions; other site
681645005636	ABC-ATPase subunit  interface; other site
681645005637	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
681645005638	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
681645005639	intersubunit interface [polypeptide binding]; other site
681645005640	UreD urease accessory protein; Region: UreD; cl00530
681645005641	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
681645005642	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
681645005643	UreF; Region: UreF; pfam01730
681645005644	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
681645005645	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
681645005646	dimer interface [polypeptide binding]; other site
681645005647	catalytic residues [active]
681645005648	urease subunit alpha; Reviewed; Region: ureC; PRK13207
681645005649	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
681645005650	subunit interactions [polypeptide binding]; other site
681645005651	active site
681645005652	flap region; other site
681645005653	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
681645005654	gamma-beta subunit interface [polypeptide binding]; other site
681645005655	alpha-beta subunit interface [polypeptide binding]; other site
681645005656	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
681645005657	alpha-gamma subunit interface [polypeptide binding]; other site
681645005658	beta-gamma subunit interface [polypeptide binding]; other site
681645005659	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
681645005660	EamA-like transporter family; Region: EamA; pfam00892
681645005661	EamA-like transporter family; Region: EamA; pfam00892
681645005662	aminotransferase AlaT; Validated; Region: PRK09265
681645005663	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
681645005664	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645005665	homodimer interface [polypeptide binding]; other site
681645005666	catalytic residue [active]
681645005667	YibE/F-like protein; Region: YibE_F; pfam07907
681645005668	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
681645005669	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
681645005670	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
681645005671	dimer interface [polypeptide binding]; other site
681645005672	putative anticodon binding site; other site
681645005673	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
681645005674	motif 1; other site
681645005675	dimer interface [polypeptide binding]; other site
681645005676	active site
681645005677	motif 2; other site
681645005678	motif 3; other site
681645005679	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
681645005680	Protein of unknown function (DUF998); Region: DUF998; pfam06197
681645005681	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
681645005682	trimer interface [polypeptide binding]; other site
681645005683	active site
681645005684	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
681645005685	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
681645005686	NAD(P) binding site [chemical binding]; other site
681645005687	catalytic residues [active]
681645005688	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
681645005689	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
681645005690	VanW like protein; Region: VanW; pfam04294
681645005691	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
681645005692	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
681645005693	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
681645005694	Acyltransferase family; Region: Acyl_transf_3; pfam01757
681645005695	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
681645005696	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
681645005697	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
681645005698	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
681645005699	active site
681645005700	substrate-binding site [chemical binding]; other site
681645005701	metal-binding site [ion binding]
681645005702	GTP binding site [chemical binding]; other site
681645005703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
681645005704	S-adenosylmethionine binding site [chemical binding]; other site
681645005705	LabA_like proteins; Region: LabA_like; cd06167
681645005706	putative metal binding site [ion binding]; other site
681645005707	MMPL family; Region: MMPL; pfam03176
681645005708	MMPL family; Region: MMPL; pfam03176
681645005709	Predicted integral membrane protein [Function unknown]; Region: COG0392
681645005710	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
681645005711	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
681645005712	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
681645005713	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
681645005714	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
681645005715	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
681645005716	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
681645005717	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
681645005718	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
681645005719	active site
681645005720	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
681645005721	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
681645005722	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
681645005723	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
681645005724	acyl-activating enzyme (AAE) consensus motif; other site
681645005725	active site
681645005726	Cutinase; Region: Cutinase; pfam01083
681645005727	Putative esterase; Region: Esterase; pfam00756
681645005728	S-formylglutathione hydrolase; Region: PLN02442
681645005729	LGFP repeat; Region: LGFP; pfam08310
681645005730	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
681645005731	LGFP repeat; Region: LGFP; pfam08310
681645005732	LGFP repeat; Region: LGFP; pfam08310
681645005733	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
681645005734	Predicted esterase [General function prediction only]; Region: COG0627
681645005735	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
681645005736	UbiA prenyltransferase family; Region: UbiA; pfam01040
681645005737	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
681645005738	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
681645005739	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
681645005740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
681645005741	Repair protein; Region: Repair_PSII; pfam04536
681645005742	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
681645005743	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
681645005744	active site
681645005745	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
681645005746	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
681645005747	active site
681645005748	catalytic site [active]
681645005749	metal binding site [ion binding]; metal-binding site
681645005750	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
681645005751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645005752	putative substrate translocation pore; other site
681645005753	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
681645005754	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
681645005755	UDP-galactopyranose mutase; Region: GLF; pfam03275
681645005756	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
681645005757	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
681645005758	Walker A/P-loop; other site
681645005759	ATP binding site [chemical binding]; other site
681645005760	Q-loop/lid; other site
681645005761	ABC transporter signature motif; other site
681645005762	Walker B; other site
681645005763	D-loop; other site
681645005764	H-loop/switch region; other site
681645005765	FecCD transport family; Region: FecCD; pfam01032
681645005766	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
681645005767	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
681645005768	putative PBP binding regions; other site
681645005769	ABC-ATPase subunit  interface; other site
681645005770	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
681645005771	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
681645005772	putative binding site residues; other site
681645005773	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
681645005774	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
681645005775	amidase catalytic site [active]
681645005776	Zn binding residues [ion binding]; other site
681645005777	substrate binding site [chemical binding]; other site
681645005778	LGFP repeat; Region: LGFP; pfam08310
681645005779	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645005780	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
681645005781	active site
681645005782	motif I; other site
681645005783	motif II; other site
681645005784	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
681645005785	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
681645005786	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
681645005787	putative acyl-acceptor binding pocket; other site
681645005788	seryl-tRNA synthetase; Provisional; Region: PRK05431
681645005789	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
681645005790	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
681645005791	dimer interface [polypeptide binding]; other site
681645005792	active site
681645005793	motif 1; other site
681645005794	motif 2; other site
681645005795	motif 3; other site
681645005796	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
681645005797	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
681645005798	DNA-binding site [nucleotide binding]; DNA binding site
681645005799	UTRA domain; Region: UTRA; pfam07702
681645005800	Septum formation; Region: Septum_form; pfam13845
681645005801	Septum formation; Region: Septum_form; pfam13845
681645005802	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
681645005803	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
681645005804	catalytic core [active]
681645005805	Prephenate dehydratase; Region: PDT; pfam00800
681645005806	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
681645005807	putative L-Phe binding site [chemical binding]; other site
681645005808	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
681645005809	Amidase; Region: Amidase; cl11426
681645005810	CAAX protease self-immunity; Region: Abi; pfam02517
681645005811	Transcriptional regulator [Transcription]; Region: LytR; COG1316
681645005812	Htaa; Region: HtaA; pfam04213
681645005813	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
681645005814	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
681645005815	putative active site [active]
681645005816	catalytic site [active]
681645005817	putative metal binding site [ion binding]; other site
681645005818	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
681645005819	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
681645005820	Nucleoside recognition; Region: Gate; pfam07670
681645005821	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
681645005822	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
681645005823	active site
681645005824	catalytic motif [active]
681645005825	Zn binding site [ion binding]; other site
681645005826	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
681645005827	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
681645005828	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
681645005829	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
681645005830	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
681645005831	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
681645005832	tetramer (dimer of dimers) interface [polypeptide binding]; other site
681645005833	NAD binding site [chemical binding]; other site
681645005834	dimer interface [polypeptide binding]; other site
681645005835	substrate binding site [chemical binding]; other site
681645005836	methionine sulfoxide reductase A; Provisional; Region: PRK00058
681645005837	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
681645005838	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
681645005839	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
681645005840	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
681645005841	Predicted flavoprotein [General function prediction only]; Region: COG0431
681645005842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645005843	putative substrate translocation pore; other site
681645005844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
681645005845	Abi-like protein; Region: Abi_2; pfam07751
681645005846	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
681645005847	homodimer interface [polypeptide binding]; other site
681645005848	chemical substrate binding site [chemical binding]; other site
681645005849	oligomer interface [polypeptide binding]; other site
681645005850	metal binding site [ion binding]; metal-binding site
681645005851	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
681645005852	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
681645005853	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
681645005854	Lsr2; Region: Lsr2; pfam11774
681645005855	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
681645005856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645005857	active site
681645005858	phosphorylation site [posttranslational modification]
681645005859	intermolecular recognition site; other site
681645005860	dimerization interface [polypeptide binding]; other site
681645005861	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
681645005862	DNA binding residues [nucleotide binding]
681645005863	dimerization interface [polypeptide binding]; other site
681645005864	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
681645005865	Histidine kinase; Region: HisKA_3; pfam07730
681645005866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
681645005867	ATP binding site [chemical binding]; other site
681645005868	Mg2+ binding site [ion binding]; other site
681645005869	G-X-G motif; other site
681645005870	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
681645005871	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
681645005872	active site
681645005873	catalytic site [active]
681645005874	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
681645005875	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
681645005876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
681645005877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
681645005878	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
681645005879	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
681645005880	Ligand Binding Site [chemical binding]; other site
681645005881	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
681645005882	Ligand Binding Site [chemical binding]; other site
681645005883	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
681645005884	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
681645005885	active site
681645005886	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
681645005887	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
681645005888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
681645005889	Walker A/P-loop; other site
681645005890	ATP binding site [chemical binding]; other site
681645005891	Q-loop/lid; other site
681645005892	ABC transporter signature motif; other site
681645005893	Walker B; other site
681645005894	D-loop; other site
681645005895	H-loop/switch region; other site
681645005896	Predicted transcriptional regulators [Transcription]; Region: COG1725
681645005897	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
681645005898	DNA-binding site [nucleotide binding]; DNA binding site
681645005899	LabA_like proteins; Region: LabA_like; cd06167
681645005900	putative metal binding site [ion binding]; other site
681645005901	Uncharacterized conserved protein [Function unknown]; Region: COG1432
681645005902	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
681645005903	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
681645005904	catalytic residues [active]
681645005905	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
681645005906	metal-binding site [ion binding]
681645005907	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
681645005908	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
681645005909	metal-binding site [ion binding]
681645005910	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
681645005911	benzoate transport; Region: 2A0115; TIGR00895
681645005912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645005913	putative substrate translocation pore; other site
681645005914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
681645005915	replicative DNA helicase; Provisional; Region: PRK05636
681645005916	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
681645005917	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
681645005918	Walker A motif; other site
681645005919	ATP binding site [chemical binding]; other site
681645005920	Walker B motif; other site
681645005921	DNA binding loops [nucleotide binding]
681645005922	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
681645005923	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
681645005924	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
681645005925	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
681645005926	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
681645005927	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
681645005928	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
681645005929	dimer interface [polypeptide binding]; other site
681645005930	ssDNA binding site [nucleotide binding]; other site
681645005931	tetramer (dimer of dimers) interface [polypeptide binding]; other site
681645005932	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
681645005933	Predicted integral membrane protein [Function unknown]; Region: COG5650
681645005934	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
681645005935	Transglycosylase; Region: Transgly; pfam00912
681645005936	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
681645005937	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
681645005938	MarR family; Region: MarR; pfam01047
681645005939	MarR family; Region: MarR_2; cl17246
681645005940	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
681645005941	Ligand Binding Site [chemical binding]; other site
681645005942	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
681645005943	Ligand Binding Site [chemical binding]; other site
681645005944	short chain dehydrogenase; Provisional; Region: PRK08219
681645005945	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
681645005946	NAD(P) binding site [chemical binding]; other site
681645005947	active site
681645005948	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
681645005949	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
681645005950	active site residue [active]
681645005951	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
681645005952	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
681645005953	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
681645005954	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
681645005955	dimerization interface [polypeptide binding]; other site
681645005956	DPS ferroxidase diiron center [ion binding]; other site
681645005957	ion pore; other site
681645005958	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
681645005959	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
681645005960	putative DNA binding site [nucleotide binding]; other site
681645005961	catalytic residue [active]
681645005962	putative H2TH interface [polypeptide binding]; other site
681645005963	putative catalytic residues [active]
681645005964	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
681645005965	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
681645005966	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
681645005967	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
681645005968	putative substrate binding site [chemical binding]; other site
681645005969	putative ATP binding site [chemical binding]; other site
681645005970	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
681645005971	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
681645005972	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
681645005973	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
681645005974	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
681645005975	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
681645005976	HIGH motif; other site
681645005977	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
681645005978	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645005979	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
681645005980	active site
681645005981	KMSKS motif; other site
681645005982	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
681645005983	tRNA binding surface [nucleotide binding]; other site
681645005984	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
681645005985	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
681645005986	Walker A/P-loop; other site
681645005987	ATP binding site [chemical binding]; other site
681645005988	Q-loop/lid; other site
681645005989	ABC transporter signature motif; other site
681645005990	Walker B; other site
681645005991	D-loop; other site
681645005992	H-loop/switch region; other site
681645005993	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
681645005994	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
681645005995	FtsX-like permease family; Region: FtsX; pfam02687
681645005996	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645005997	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645005998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
681645005999	Histidine kinase; Region: HisKA_3; pfam07730
681645006000	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
681645006001	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
681645006002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
681645006003	active site
681645006004	phosphorylation site [posttranslational modification]
681645006005	intermolecular recognition site; other site
681645006006	dimerization interface [polypeptide binding]; other site
681645006007	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
681645006008	DNA binding residues [nucleotide binding]
681645006009	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645006010	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
681645006011	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645006012	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
681645006013	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
681645006014	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
681645006015	active site
681645006016	trimer interface [polypeptide binding]; other site
681645006017	allosteric site; other site
681645006018	active site lid [active]
681645006019	hexamer (dimer of trimers) interface [polypeptide binding]; other site
681645006020	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
681645006021	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
681645006022	active site
681645006023	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
681645006024	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
681645006025	putative active site cavity [active]
681645006026	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
681645006027	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
681645006028	nucleotide binding site [chemical binding]; other site
681645006029	Transcriptional regulators [Transcription]; Region: FadR; COG2186
681645006030	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
681645006031	DNA-binding site [nucleotide binding]; DNA binding site
681645006032	FCD domain; Region: FCD; pfam07729
681645006033	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
681645006034	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
681645006035	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
681645006036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645006037	dimer interface [polypeptide binding]; other site
681645006038	conserved gate region; other site
681645006039	putative PBP binding loops; other site
681645006040	ABC-ATPase subunit interface; other site
681645006041	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
681645006042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
681645006043	dimer interface [polypeptide binding]; other site
681645006044	conserved gate region; other site
681645006045	putative PBP binding loops; other site
681645006046	ABC-ATPase subunit interface; other site
681645006047	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
681645006048	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645006049	Walker A/P-loop; other site
681645006050	ATP binding site [chemical binding]; other site
681645006051	Q-loop/lid; other site
681645006052	ABC transporter signature motif; other site
681645006053	Walker B; other site
681645006054	D-loop; other site
681645006055	H-loop/switch region; other site
681645006056	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
681645006057	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
681645006058	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
681645006059	Walker A/P-loop; other site
681645006060	ATP binding site [chemical binding]; other site
681645006061	Q-loop/lid; other site
681645006062	ABC transporter signature motif; other site
681645006063	Walker B; other site
681645006064	D-loop; other site
681645006065	H-loop/switch region; other site
681645006066	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
681645006067	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
681645006068	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
681645006069	inhibitor site; inhibition site
681645006070	active site
681645006071	dimer interface [polypeptide binding]; other site
681645006072	catalytic residue [active]
681645006073	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
681645006074	active site
681645006075	catalytic residues [active]
681645006076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
681645006077	hypothetical protein; Provisional; Region: PRK13663
681645006078	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
681645006079	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
681645006080	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
681645006081	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
681645006082	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
681645006083	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
681645006084	substrate binding pocket [chemical binding]; other site
681645006085	substrate-Mg2+ binding site; other site
681645006086	aspartate-rich region 1; other site
681645006087	aspartate-rich region 2; other site
681645006088	phytoene desaturase; Region: crtI_fam; TIGR02734
681645006089	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
681645006090	SdpI/YhfL protein family; Region: SdpI; pfam13630
681645006091	anthranilate synthase component I; Provisional; Region: PRK13564
681645006092	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
681645006093	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
681645006094	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
681645006095	Glutamine amidotransferase class-I; Region: GATase; pfam00117
681645006096	glutamine binding [chemical binding]; other site
681645006097	catalytic triad [active]
681645006098	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
681645006099	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
681645006100	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
681645006101	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
681645006102	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
681645006103	active site
681645006104	ribulose/triose binding site [chemical binding]; other site
681645006105	phosphate binding site [ion binding]; other site
681645006106	substrate (anthranilate) binding pocket [chemical binding]; other site
681645006107	product (indole) binding pocket [chemical binding]; other site
681645006108	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
681645006109	active site
681645006110	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
681645006111	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
681645006112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
681645006113	catalytic residue [active]
681645006114	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
681645006115	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
681645006116	substrate binding site [chemical binding]; other site
681645006117	active site
681645006118	catalytic residues [active]
681645006119	heterodimer interface [polypeptide binding]; other site
681645006120	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
681645006121	iron-sulfur cluster [ion binding]; other site
681645006122	[2Fe-2S] cluster binding site [ion binding]; other site
681645006123	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
681645006124	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
681645006125	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
681645006126	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
681645006127	hypothetical protein; Validated; Region: PRK00228
681645006128	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
681645006129	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
681645006130	active site
681645006131	NTP binding site [chemical binding]; other site
681645006132	metal binding triad [ion binding]; metal-binding site
681645006133	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
681645006134	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
681645006135	Zn2+ binding site [ion binding]; other site
681645006136	Mg2+ binding site [ion binding]; other site
681645006137	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
681645006138	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
681645006139	active site
681645006140	Ap6A binding site [chemical binding]; other site
681645006141	nudix motif; other site
681645006142	metal binding site [ion binding]; metal-binding site
681645006143	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
681645006144	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
681645006145	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
681645006146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
681645006147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
681645006148	DNA binding residues [nucleotide binding]
681645006149	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
681645006150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
681645006151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
681645006152	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
681645006153	catalytic residues [active]
681645006154	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
681645006155	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
681645006156	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
681645006157	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
681645006158	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
681645006159	active site
681645006160	metal binding site [ion binding]; metal-binding site
681645006161	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
681645006162	ParB-like nuclease domain; Region: ParBc; pfam02195
681645006163	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
681645006164	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
681645006165	P-loop; other site
681645006166	Magnesium ion binding site [ion binding]; other site
681645006167	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
681645006168	Magnesium ion binding site [ion binding]; other site
681645006169	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
681645006170	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
681645006171	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
681645006172	Haemolytic domain; Region: Haemolytic; pfam01809
681645006173	ribonuclease P; Reviewed; Region: rnpA; PRK03459
681645006174	Ribosomal protein L34; Region: Ribosomal_L34; cl00370