-- dump date 20140619_052504 -- class Genbank::misc_feature -- table misc_feature_note -- id note 935697000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 935697000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697000003 Walker A motif; other site 935697000004 ATP binding site [chemical binding]; other site 935697000005 Walker B motif; other site 935697000006 arginine finger; other site 935697000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 935697000008 DnaA box-binding interface [nucleotide binding]; other site 935697000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 935697000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 935697000011 putative DNA binding surface [nucleotide binding]; other site 935697000012 dimer interface [polypeptide binding]; other site 935697000013 beta-clamp/clamp loader binding surface; other site 935697000014 beta-clamp/translesion DNA polymerase binding surface; other site 935697000015 recombination protein F; Reviewed; Region: recF; PRK00064 935697000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 935697000017 Walker A/P-loop; other site 935697000018 ATP binding site [chemical binding]; other site 935697000019 Q-loop/lid; other site 935697000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697000021 ABC transporter signature motif; other site 935697000022 Walker B; other site 935697000023 D-loop; other site 935697000024 H-loop/switch region; other site 935697000025 hypothetical protein; Provisional; Region: PRK00111 935697000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 935697000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697000028 ATP binding site [chemical binding]; other site 935697000029 Mg2+ binding site [ion binding]; other site 935697000030 G-X-G motif; other site 935697000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935697000032 anchoring element; other site 935697000033 dimer interface [polypeptide binding]; other site 935697000034 ATP binding site [chemical binding]; other site 935697000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 935697000036 active site 935697000037 putative metal-binding site [ion binding]; other site 935697000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935697000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 935697000040 metal binding site [ion binding]; metal-binding site 935697000041 DNA gyrase subunit A; Validated; Region: PRK05560 935697000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935697000043 CAP-like domain; other site 935697000044 active site 935697000045 primary dimer interface [polypeptide binding]; other site 935697000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935697000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935697000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935697000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935697000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935697000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935697000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 935697000053 YwiC-like protein; Region: YwiC; pfam14256 935697000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 935697000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 935697000056 putative ligand binding site [chemical binding]; other site 935697000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 935697000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 935697000059 TM-ABC transporter signature motif; other site 935697000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 935697000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 935697000062 Walker A/P-loop; other site 935697000063 ATP binding site [chemical binding]; other site 935697000064 Q-loop/lid; other site 935697000065 ABC transporter signature motif; other site 935697000066 Walker B; other site 935697000067 D-loop; other site 935697000068 H-loop/switch region; other site 935697000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 935697000070 active site 935697000071 Rhomboid family; Region: Rhomboid; pfam01694 935697000072 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 935697000073 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 935697000074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 935697000075 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 935697000076 putative active site [active] 935697000077 catalytic site [active] 935697000078 Mg binding site [ion binding]; other site 935697000079 catalytic loop [active] 935697000080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 935697000081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697000082 Walker A/P-loop; other site 935697000083 ATP binding site [chemical binding]; other site 935697000084 Q-loop/lid; other site 935697000085 ABC transporter signature motif; other site 935697000086 Walker B; other site 935697000087 D-loop; other site 935697000088 H-loop/switch region; other site 935697000089 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 935697000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697000091 ABC-ATPase subunit interface; other site 935697000092 dimer interface [polypeptide binding]; other site 935697000093 putative PBP binding regions; other site 935697000094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697000095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697000096 ABC-ATPase subunit interface; other site 935697000097 dimer interface [polypeptide binding]; other site 935697000098 putative PBP binding regions; other site 935697000099 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935697000100 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 935697000101 siderophore binding site; other site 935697000102 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 935697000103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 935697000104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 935697000105 active site 935697000106 ATP binding site [chemical binding]; other site 935697000107 substrate binding site [chemical binding]; other site 935697000108 activation loop (A-loop); other site 935697000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 935697000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697000111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697000112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697000113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697000114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 935697000115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 935697000116 active site 935697000117 ATP binding site [chemical binding]; other site 935697000118 substrate binding site [chemical binding]; other site 935697000119 activation loop (A-loop); other site 935697000120 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 935697000121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935697000122 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 935697000123 Protein phosphatase 2C; Region: PP2C; pfam00481 935697000124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 935697000125 active site 935697000126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 935697000127 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 935697000128 phosphopeptide binding site; other site 935697000129 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 935697000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 935697000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 935697000132 phosphopeptide binding site; other site 935697000133 CAAX protease self-immunity; Region: Abi; pfam02517 935697000134 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 935697000135 Predicted transcriptional regulators [Transcription]; Region: COG1695 935697000136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 935697000137 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 935697000138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697000139 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 935697000140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 935697000141 Divalent cation transporter; Region: MgtE; pfam01769 935697000142 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 935697000143 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 935697000144 active site 935697000145 catalytic site [active] 935697000146 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 935697000147 Anti-sigma-K factor rskA; Region: RskA; pfam10099 935697000148 RNA polymerase sigma factor; Provisional; Region: PRK12537 935697000149 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697000150 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697000151 DNA binding residues [nucleotide binding] 935697000152 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 935697000153 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 935697000154 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 935697000155 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935697000156 catalytic residues [active] 935697000157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 935697000158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697000159 dimer interface [polypeptide binding]; other site 935697000160 conserved gate region; other site 935697000161 putative PBP binding loops; other site 935697000162 ABC-ATPase subunit interface; other site 935697000163 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 935697000164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697000165 Walker A/P-loop; other site 935697000166 ATP binding site [chemical binding]; other site 935697000167 Q-loop/lid; other site 935697000168 ABC transporter signature motif; other site 935697000169 Walker B; other site 935697000170 D-loop; other site 935697000171 H-loop/switch region; other site 935697000172 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 935697000173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697000174 Coenzyme A binding pocket [chemical binding]; other site 935697000175 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 935697000176 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 935697000177 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 935697000178 putative metal binding site [ion binding]; other site 935697000179 biotin synthase; Validated; Region: PRK06256 935697000180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697000181 FeS/SAM binding site; other site 935697000182 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 935697000183 MepB protein; Region: MepB; cl01985 935697000184 AMP nucleosidase; Provisional; Region: PRK08292 935697000185 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 935697000186 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 935697000187 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 935697000188 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 935697000189 active site 935697000190 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 935697000191 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 935697000192 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 935697000193 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 935697000194 Lipase (class 2); Region: Lipase_2; pfam01674 935697000195 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 935697000196 dimer interface [polypeptide binding]; other site 935697000197 FMN binding site [chemical binding]; other site 935697000198 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 935697000199 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 935697000200 trimer interface [polypeptide binding]; other site 935697000201 putative metal binding site [ion binding]; other site 935697000202 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 935697000203 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 935697000204 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 935697000205 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 935697000206 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 935697000207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697000208 Coenzyme A binding pocket [chemical binding]; other site 935697000209 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 935697000210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 935697000211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935697000212 MarR family; Region: MarR; pfam01047 935697000213 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 935697000214 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 935697000215 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 935697000216 hypothetical protein; Provisional; Region: PRK10621 935697000217 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935697000218 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 935697000219 active site 935697000220 phosphorylation site [posttranslational modification] 935697000221 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 935697000222 active site 935697000223 P-loop; other site 935697000224 phosphorylation site [posttranslational modification] 935697000225 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 935697000226 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 935697000227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697000228 ATP binding site [chemical binding]; other site 935697000229 putative Mg++ binding site [ion binding]; other site 935697000230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697000231 nucleotide binding region [chemical binding]; other site 935697000232 ATP-binding site [chemical binding]; other site 935697000233 Helicase associated domain (HA2); Region: HA2; pfam04408 935697000234 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 935697000235 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 935697000236 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 935697000237 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 935697000238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697000239 NAD(P) binding site [chemical binding]; other site 935697000240 active site 935697000241 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 935697000242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697000243 RNA binding surface [nucleotide binding]; other site 935697000244 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 935697000245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935697000246 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 935697000247 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 935697000248 DNA binding site [nucleotide binding] 935697000249 active site 935697000250 Domain of unknown function (DUF222); Region: DUF222; pfam02720 935697000251 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 935697000252 active site 935697000253 glycerol kinase; Provisional; Region: glpK; PRK00047 935697000254 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 935697000255 nucleotide binding site [chemical binding]; other site 935697000256 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 935697000257 amphipathic channel; other site 935697000258 Asn-Pro-Ala signature motifs; other site 935697000259 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 935697000260 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 935697000261 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 935697000262 active site 935697000263 Zn binding site [ion binding]; other site 935697000264 Protease prsW family; Region: PrsW-protease; pfam13367 935697000265 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 935697000266 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 935697000267 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 935697000268 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 935697000269 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 935697000270 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 935697000271 classical (c) SDRs; Region: SDR_c; cd05233 935697000272 NAD(P) binding site [chemical binding]; other site 935697000273 active site 935697000274 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935697000275 FAD binding domain; Region: FAD_binding_4; pfam01565 935697000276 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 935697000277 Predicted membrane protein [Function unknown]; Region: COG2246 935697000278 GtrA-like protein; Region: GtrA; pfam04138 935697000279 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 935697000280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 935697000281 active site 935697000282 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697000283 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 935697000284 intersubunit interface [polypeptide binding]; other site 935697000285 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 935697000286 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 935697000287 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935697000288 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 935697000289 dimer interface [polypeptide binding]; other site 935697000290 putative PBP binding regions; other site 935697000291 ABC-ATPase subunit interface; other site 935697000292 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935697000293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697000294 ABC-ATPase subunit interface; other site 935697000295 dimer interface [polypeptide binding]; other site 935697000296 putative PBP binding regions; other site 935697000297 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697000298 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 935697000299 intersubunit interface [polypeptide binding]; other site 935697000300 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 935697000301 active site 935697000302 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 935697000303 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 935697000304 Walker A/P-loop; other site 935697000305 ATP binding site [chemical binding]; other site 935697000306 Q-loop/lid; other site 935697000307 ABC transporter signature motif; other site 935697000308 Walker B; other site 935697000309 D-loop; other site 935697000310 H-loop/switch region; other site 935697000311 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 935697000312 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 935697000313 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 935697000314 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 935697000315 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 935697000316 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 935697000317 NAD(P) binding site [chemical binding]; other site 935697000318 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 935697000319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697000321 homodimer interface [polypeptide binding]; other site 935697000322 catalytic residue [active] 935697000323 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 935697000324 transmembrane helices; other site 935697000325 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935697000326 CAT RNA binding domain; Region: CAT_RBD; smart01061 935697000327 PRD domain; Region: PRD; pfam00874 935697000328 PRD domain; Region: PRD; pfam00874 935697000329 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 935697000330 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935697000331 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 935697000332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935697000333 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 935697000334 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 935697000335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935697000336 DNA-binding site [nucleotide binding]; DNA binding site 935697000337 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697000338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697000339 homodimer interface [polypeptide binding]; other site 935697000340 catalytic residue [active] 935697000341 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 935697000342 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 935697000343 active site 935697000344 multimer interface [polypeptide binding]; other site 935697000345 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 935697000346 conserved cys residue [active] 935697000347 prephenate dehydrogenase; Validated; Region: PRK06545 935697000348 prephenate dehydrogenase; Validated; Region: PRK08507 935697000349 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 935697000350 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 935697000351 nucleoside/Zn binding site; other site 935697000352 dimer interface [polypeptide binding]; other site 935697000353 catalytic motif [active] 935697000354 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 935697000355 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 935697000356 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 935697000357 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 935697000358 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 935697000359 active site 935697000360 KMSKS motif; other site 935697000361 fructuronate transporter; Provisional; Region: PRK10034; cl15264 935697000362 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 935697000363 Shikimate kinase; Region: SKI; pfam01202 935697000364 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 935697000365 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 935697000366 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 935697000367 putative NAD(P) binding site [chemical binding]; other site 935697000368 catalytic Zn binding site [ion binding]; other site 935697000369 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 935697000370 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 935697000371 NADP binding site [chemical binding]; other site 935697000372 homodimer interface [polypeptide binding]; other site 935697000373 active site 935697000374 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 935697000375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697000377 homodimer interface [polypeptide binding]; other site 935697000378 catalytic residue [active] 935697000379 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 935697000380 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 935697000381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697000382 Walker A motif; other site 935697000383 ATP binding site [chemical binding]; other site 935697000384 Walker B motif; other site 935697000385 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 935697000386 arginine finger; other site 935697000387 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 935697000388 hypothetical protein; Validated; Region: PRK00153 935697000389 recombination protein RecR; Reviewed; Region: recR; PRK00076 935697000390 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 935697000391 RecR protein; Region: RecR; pfam02132 935697000392 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 935697000393 putative active site [active] 935697000394 putative metal-binding site [ion binding]; other site 935697000395 tetramer interface [polypeptide binding]; other site 935697000396 putative transporter; Provisional; Region: PRK09821 935697000397 GntP family permease; Region: GntP_permease; pfam02447 935697000398 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 935697000399 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 935697000400 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935697000401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 935697000402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935697000403 Transcriptional regulators [Transcription]; Region: FadR; COG2186 935697000404 DNA-binding site [nucleotide binding]; DNA binding site 935697000405 FCD domain; Region: FCD; pfam07729 935697000406 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 935697000407 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 935697000408 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 935697000409 catalytic triad [active] 935697000410 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 935697000411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697000412 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 935697000413 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 935697000414 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 935697000415 active site 935697000416 catalytic site [active] 935697000417 substrate binding site [chemical binding]; other site 935697000418 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 935697000419 2-isopropylmalate synthase; Validated; Region: PRK03739 935697000420 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 935697000421 active site 935697000422 catalytic residues [active] 935697000423 metal binding site [ion binding]; metal-binding site 935697000424 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 935697000425 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 935697000426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697000427 DNA binding residues [nucleotide binding] 935697000428 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 935697000429 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 935697000430 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 935697000431 intersubunit interface [polypeptide binding]; other site 935697000432 active site 935697000433 catalytic residue [active] 935697000434 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 935697000435 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 935697000436 active site 935697000437 substrate binding site [chemical binding]; other site 935697000438 metal binding site [ion binding]; metal-binding site 935697000439 TQXA domain; Region: TQXA_dom; TIGR03934 935697000440 aspartate kinase; Reviewed; Region: PRK06635 935697000441 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 935697000442 putative nucleotide binding site [chemical binding]; other site 935697000443 putative catalytic residues [active] 935697000444 putative Mg ion binding site [ion binding]; other site 935697000445 putative aspartate binding site [chemical binding]; other site 935697000446 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 935697000447 putative allosteric regulatory site; other site 935697000448 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 935697000449 putative allosteric regulatory residue; other site 935697000450 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 935697000451 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935697000452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697000453 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 935697000454 DNA binding residues [nucleotide binding] 935697000455 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 935697000456 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 935697000457 heme binding pocket [chemical binding]; other site 935697000458 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935697000459 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935697000460 Walker A/P-loop; other site 935697000461 ATP binding site [chemical binding]; other site 935697000462 Q-loop/lid; other site 935697000463 ABC transporter signature motif; other site 935697000464 Walker B; other site 935697000465 D-loop; other site 935697000466 H-loop/switch region; other site 935697000467 TOBE domain; Region: TOBE_2; pfam08402 935697000468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697000469 dimer interface [polypeptide binding]; other site 935697000470 conserved gate region; other site 935697000471 ABC-ATPase subunit interface; other site 935697000472 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 935697000473 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 935697000474 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 935697000475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697000476 putative substrate translocation pore; other site 935697000477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935697000478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697000479 active site 935697000480 phosphorylation site [posttranslational modification] 935697000481 intermolecular recognition site; other site 935697000482 dimerization interface [polypeptide binding]; other site 935697000483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935697000484 DNA binding site [nucleotide binding] 935697000485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935697000486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697000487 ATP binding site [chemical binding]; other site 935697000488 Mg2+ binding site [ion binding]; other site 935697000489 G-X-G motif; other site 935697000490 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 935697000491 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 935697000492 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 935697000493 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 935697000494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935697000495 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 935697000496 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 935697000497 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935697000498 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 935697000499 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 935697000500 Predicted membrane protein [Function unknown]; Region: COG1511 935697000501 Predicted membrane protein [Function unknown]; Region: COG1511 935697000502 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 935697000503 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 935697000504 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 935697000505 putative active site [active] 935697000506 putative metal binding site [ion binding]; other site 935697000507 Yqey-like protein; Region: YqeY; pfam09424 935697000508 Transglycosylase; Region: Transgly; pfam00912 935697000509 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 935697000510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 935697000511 PASTA domain; Region: PASTA; pfam03793 935697000512 Transcription factor WhiB; Region: Whib; pfam02467 935697000513 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 935697000514 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 935697000515 homotrimer interaction site [polypeptide binding]; other site 935697000516 putative active site [active] 935697000517 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 935697000518 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 935697000519 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 935697000520 ligand binding site [chemical binding]; other site 935697000521 flexible hinge region; other site 935697000522 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 935697000523 putative switch regulator; other site 935697000524 non-specific DNA interactions [nucleotide binding]; other site 935697000525 DNA binding site [nucleotide binding] 935697000526 sequence specific DNA binding site [nucleotide binding]; other site 935697000527 putative cAMP binding site [chemical binding]; other site 935697000528 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 935697000529 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935697000530 minor groove reading motif; other site 935697000531 helix-hairpin-helix signature motif; other site 935697000532 substrate binding pocket [chemical binding]; other site 935697000533 active site 935697000534 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 935697000535 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935697000536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935697000537 catalytic residues [active] 935697000538 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 935697000539 putative active site [active] 935697000540 putative CoA binding site [chemical binding]; other site 935697000541 nudix motif; other site 935697000542 metal binding site [ion binding]; metal-binding site 935697000543 Colicin V production protein; Region: Colicin_V; pfam02674 935697000544 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 935697000545 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 935697000546 active site 935697000547 substrate binding sites [chemical binding]; other site 935697000548 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 935697000549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 935697000550 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935697000551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697000552 motif II; other site 935697000553 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 935697000554 Type II/IV secretion system protein; Region: T2SE; pfam00437 935697000555 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 935697000556 ATP binding site [chemical binding]; other site 935697000557 Walker A motif; other site 935697000558 hexamer interface [polypeptide binding]; other site 935697000559 Walker B motif; other site 935697000560 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 935697000561 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 935697000562 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 935697000563 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 935697000564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697000565 ATP binding site [chemical binding]; other site 935697000566 putative Mg++ binding site [ion binding]; other site 935697000567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697000568 nucleotide binding region [chemical binding]; other site 935697000569 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 935697000570 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 935697000571 DNA-binding site [nucleotide binding]; DNA binding site 935697000572 RNA-binding motif; other site 935697000573 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 935697000574 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 935697000575 active site 935697000576 interdomain interaction site; other site 935697000577 putative metal-binding site [ion binding]; other site 935697000578 nucleotide binding site [chemical binding]; other site 935697000579 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 935697000580 domain I; other site 935697000581 DNA binding groove [nucleotide binding] 935697000582 phosphate binding site [ion binding]; other site 935697000583 domain II; other site 935697000584 domain III; other site 935697000585 nucleotide binding site [chemical binding]; other site 935697000586 catalytic site [active] 935697000587 domain IV; other site 935697000588 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 935697000589 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 935697000590 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 935697000591 Predicted membrane protein [Function unknown]; Region: COG1297 935697000592 putative oligopeptide transporter, OPT family; Region: TIGR00733 935697000593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935697000594 dimerization interface [polypeptide binding]; other site 935697000595 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 935697000596 cyclase homology domain; Region: CHD; cd07302 935697000597 nucleotidyl binding site; other site 935697000598 metal binding site [ion binding]; metal-binding site 935697000599 dimer interface [polypeptide binding]; other site 935697000600 DNA polymerase III subunit delta'; Validated; Region: PRK07940 935697000601 DNA polymerase III subunit delta'; Validated; Region: PRK08485 935697000602 acyl-CoA synthetase; Validated; Region: PRK07788 935697000603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697000604 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697000605 acyl-activating enzyme (AAE) consensus motif; other site 935697000606 acyl-activating enzyme (AAE) consensus motif; other site 935697000607 AMP binding site [chemical binding]; other site 935697000608 active site 935697000609 CoA binding site [chemical binding]; other site 935697000610 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 935697000611 active site 935697000612 catalytic triad [active] 935697000613 oxyanion hole [active] 935697000614 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935697000615 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935697000616 substrate binding site; other site 935697000617 tetramer interface; other site 935697000618 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 935697000619 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 935697000620 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 935697000621 NADP binding site [chemical binding]; other site 935697000622 active site 935697000623 putative substrate binding site [chemical binding]; other site 935697000624 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 935697000625 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935697000626 NAD binding site [chemical binding]; other site 935697000627 substrate binding site [chemical binding]; other site 935697000628 homodimer interface [polypeptide binding]; other site 935697000629 active site 935697000630 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 935697000631 Zn binding site [ion binding]; other site 935697000632 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 935697000633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935697000634 Putative esterase; Region: Esterase; pfam00756 935697000635 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 935697000636 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 935697000637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935697000638 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935697000639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935697000640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935697000641 non-specific DNA binding site [nucleotide binding]; other site 935697000642 salt bridge; other site 935697000643 sequence-specific DNA binding site [nucleotide binding]; other site 935697000644 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 935697000645 Domain of unknown function (DUF955); Region: DUF955; pfam06114 935697000646 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 935697000647 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 935697000648 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 935697000649 putative Iron-sulfur protein interface [polypeptide binding]; other site 935697000650 proximal heme binding site [chemical binding]; other site 935697000651 distal heme binding site [chemical binding]; other site 935697000652 putative dimer interface [polypeptide binding]; other site 935697000653 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 935697000654 L-aspartate oxidase; Provisional; Region: PRK06175 935697000655 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935697000656 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 935697000657 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 935697000658 Predicted membrane protein [Function unknown]; Region: COG2733 935697000659 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 935697000660 Class I aldolases; Region: Aldolase_Class_I; cl17187 935697000661 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 935697000662 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 935697000663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697000664 FeS/SAM binding site; other site 935697000665 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 935697000666 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 935697000667 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 935697000668 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 935697000669 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 935697000670 FAD binding domain; Region: FAD_binding_4; pfam01565 935697000671 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 935697000672 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 935697000673 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935697000674 acyl-activating enzyme (AAE) consensus motif; other site 935697000675 putative AMP binding site [chemical binding]; other site 935697000676 putative active site [active] 935697000677 putative CoA binding site [chemical binding]; other site 935697000678 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 935697000679 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 935697000680 putative ADP-binding pocket [chemical binding]; other site 935697000681 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697000682 catalytic core [active] 935697000683 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697000684 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 935697000685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935697000686 dimer interface [polypeptide binding]; other site 935697000687 phosphorylation site [posttranslational modification] 935697000688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697000689 ATP binding site [chemical binding]; other site 935697000690 Mg2+ binding site [ion binding]; other site 935697000691 G-X-G motif; other site 935697000692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935697000693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697000694 active site 935697000695 phosphorylation site [posttranslational modification] 935697000696 intermolecular recognition site; other site 935697000697 dimerization interface [polypeptide binding]; other site 935697000698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935697000699 DNA binding site [nucleotide binding] 935697000700 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 935697000701 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 935697000702 DNA binding domain, excisionase family; Region: excise; TIGR01764 935697000703 Thioredoxin; Region: Thioredoxin_4; cl17273 935697000704 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 935697000705 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 935697000706 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 935697000707 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935697000708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697000709 motif II; other site 935697000710 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 935697000711 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 935697000712 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 935697000713 tRNA; other site 935697000714 putative tRNA binding site [nucleotide binding]; other site 935697000715 putative NADP binding site [chemical binding]; other site 935697000716 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 935697000717 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 935697000718 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 935697000719 domain interfaces; other site 935697000720 active site 935697000721 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 935697000722 active site 935697000723 homodimer interface [polypeptide binding]; other site 935697000724 SAM binding site [chemical binding]; other site 935697000725 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 935697000726 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 935697000727 active site 935697000728 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 935697000729 dimer interface [polypeptide binding]; other site 935697000730 active site 935697000731 Schiff base residues; other site 935697000732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935697000733 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 935697000734 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 935697000735 substrate binding site [chemical binding]; other site 935697000736 active site 935697000737 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 935697000738 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 935697000739 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935697000740 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 935697000741 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935697000742 inhibitor-cofactor binding pocket; inhibition site 935697000743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697000744 catalytic residue [active] 935697000745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697000746 catalytic core [active] 935697000747 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935697000748 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935697000749 catalytic residues [active] 935697000750 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 935697000751 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 935697000752 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 935697000753 ResB-like family; Region: ResB; pfam05140 935697000754 Methyltransferase domain; Region: Methyltransf_31; pfam13847 935697000755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697000756 S-adenosylmethionine binding site [chemical binding]; other site 935697000757 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 935697000758 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697000759 Walker A/P-loop; other site 935697000760 ATP binding site [chemical binding]; other site 935697000761 Q-loop/lid; other site 935697000762 ABC transporter signature motif; other site 935697000763 Walker B; other site 935697000764 D-loop; other site 935697000765 H-loop/switch region; other site 935697000766 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 935697000767 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697000768 intersubunit interface [polypeptide binding]; other site 935697000769 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 935697000770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697000771 ABC-ATPase subunit interface; other site 935697000772 dimer interface [polypeptide binding]; other site 935697000773 putative PBP binding regions; other site 935697000774 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 935697000775 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 935697000776 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 935697000777 UbiA prenyltransferase family; Region: UbiA; pfam01040 935697000778 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 935697000779 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697000780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697000781 acyl-activating enzyme (AAE) consensus motif; other site 935697000782 acyl-activating enzyme (AAE) consensus motif; other site 935697000783 AMP binding site [chemical binding]; other site 935697000784 active site 935697000785 CoA binding site [chemical binding]; other site 935697000786 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 935697000787 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 935697000788 substrate binding site [chemical binding]; other site 935697000789 oxyanion hole (OAH) forming residues; other site 935697000790 trimer interface [polypeptide binding]; other site 935697000791 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 935697000792 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 935697000793 O-succinylbenzoate synthase; Provisional; Region: PRK02901 935697000794 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 935697000795 active site 935697000796 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 935697000797 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 935697000798 dimer interface [polypeptide binding]; other site 935697000799 tetramer interface [polypeptide binding]; other site 935697000800 PYR/PP interface [polypeptide binding]; other site 935697000801 TPP binding site [chemical binding]; other site 935697000802 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 935697000803 TPP-binding site; other site 935697000804 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 935697000805 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 935697000806 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935697000807 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 935697000808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697000809 S-adenosylmethionine binding site [chemical binding]; other site 935697000810 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 935697000811 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 935697000812 NAD(P) binding site [chemical binding]; other site 935697000813 LDH/MDH dimer interface [polypeptide binding]; other site 935697000814 substrate binding site [chemical binding]; other site 935697000815 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 935697000816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935697000817 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935697000818 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935697000819 substrate binding pocket [chemical binding]; other site 935697000820 chain length determination region; other site 935697000821 substrate-Mg2+ binding site; other site 935697000822 catalytic residues [active] 935697000823 aspartate-rich region 1; other site 935697000824 active site lid residues [active] 935697000825 aspartate-rich region 2; other site 935697000826 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 935697000827 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 935697000828 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 935697000829 putative homodimer interface [polypeptide binding]; other site 935697000830 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 935697000831 heterodimer interface [polypeptide binding]; other site 935697000832 homodimer interface [polypeptide binding]; other site 935697000833 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 935697000834 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 935697000835 23S rRNA interface [nucleotide binding]; other site 935697000836 L7/L12 interface [polypeptide binding]; other site 935697000837 putative thiostrepton binding site; other site 935697000838 L25 interface [polypeptide binding]; other site 935697000839 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 935697000840 mRNA/rRNA interface [nucleotide binding]; other site 935697000841 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 935697000842 trimer interface [polypeptide binding]; other site 935697000843 active site 935697000844 G bulge; other site 935697000845 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 935697000846 trimer interface [polypeptide binding]; other site 935697000847 active site 935697000848 G bulge; other site 935697000849 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 935697000850 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 935697000851 FMN binding site [chemical binding]; other site 935697000852 active site 935697000853 substrate binding site [chemical binding]; other site 935697000854 catalytic residue [active] 935697000855 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 935697000856 L11 interface [polypeptide binding]; other site 935697000857 putative EF-Tu interaction site [polypeptide binding]; other site 935697000858 putative EF-G interaction site [polypeptide binding]; other site 935697000859 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 935697000860 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 935697000861 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697000862 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 935697000863 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697000864 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 935697000865 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 935697000866 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 935697000867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 935697000868 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935697000869 ABC-ATPase subunit interface; other site 935697000870 dimer interface [polypeptide binding]; other site 935697000871 putative PBP binding regions; other site 935697000872 Ethylene insensitive 3; Region: EIN3; cl04813 935697000873 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 935697000874 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 935697000875 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 935697000876 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 935697000877 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935697000878 RPB1 interaction site [polypeptide binding]; other site 935697000879 RPB10 interaction site [polypeptide binding]; other site 935697000880 RPB11 interaction site [polypeptide binding]; other site 935697000881 RPB3 interaction site [polypeptide binding]; other site 935697000882 RPB12 interaction site [polypeptide binding]; other site 935697000883 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 935697000884 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 935697000885 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 935697000886 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 935697000887 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 935697000888 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 935697000889 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 935697000890 G-loop; other site 935697000891 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 935697000892 DNA binding site [nucleotide binding] 935697000893 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 935697000894 Histidine kinase; Region: HisKA_3; pfam07730 935697000895 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 935697000896 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 935697000897 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 935697000898 Walker A/P-loop; other site 935697000899 ATP binding site [chemical binding]; other site 935697000900 Q-loop/lid; other site 935697000901 ABC transporter signature motif; other site 935697000902 Walker B; other site 935697000903 D-loop; other site 935697000904 H-loop/switch region; other site 935697000905 TIGR03943 family protein; Region: TIGR03943 935697000906 Predicted permease; Region: DUF318; cl17795 935697000907 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 935697000908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697000909 FeS/SAM binding site; other site 935697000910 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 935697000911 Class III ribonucleotide reductase; Region: RNR_III; cd01675 935697000912 effector binding site; other site 935697000913 active site 935697000914 Zn binding site [ion binding]; other site 935697000915 glycine loop; other site 935697000916 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 935697000917 S17 interaction site [polypeptide binding]; other site 935697000918 S8 interaction site; other site 935697000919 16S rRNA interaction site [nucleotide binding]; other site 935697000920 streptomycin interaction site [chemical binding]; other site 935697000921 23S rRNA interaction site [nucleotide binding]; other site 935697000922 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 935697000923 30S ribosomal protein S7; Validated; Region: PRK05302 935697000924 elongation factor G; Reviewed; Region: PRK00007 935697000925 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 935697000926 G1 box; other site 935697000927 putative GEF interaction site [polypeptide binding]; other site 935697000928 GTP/Mg2+ binding site [chemical binding]; other site 935697000929 Switch I region; other site 935697000930 G2 box; other site 935697000931 G3 box; other site 935697000932 Switch II region; other site 935697000933 G4 box; other site 935697000934 G5 box; other site 935697000935 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 935697000936 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 935697000937 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 935697000938 elongation factor Tu; Reviewed; Region: PRK00049 935697000939 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935697000940 G1 box; other site 935697000941 GEF interaction site [polypeptide binding]; other site 935697000942 GTP/Mg2+ binding site [chemical binding]; other site 935697000943 Switch I region; other site 935697000944 G2 box; other site 935697000945 G3 box; other site 935697000946 Switch II region; other site 935697000947 G4 box; other site 935697000948 G5 box; other site 935697000949 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935697000950 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935697000951 Antibiotic Binding Site [chemical binding]; other site 935697000952 Asp23 family; Region: Asp23; cl00574 935697000953 Asp23 family; Region: Asp23; cl00574 935697000954 Asp23 family; Region: Asp23; pfam03780 935697000955 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 935697000956 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 935697000957 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 935697000958 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 935697000959 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 935697000960 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 935697000961 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 935697000962 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 935697000963 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 935697000964 putative translocon binding site; other site 935697000965 protein-rRNA interface [nucleotide binding]; other site 935697000966 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 935697000967 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 935697000968 G-X-X-G motif; other site 935697000969 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 935697000970 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 935697000971 23S rRNA interface [nucleotide binding]; other site 935697000972 5S rRNA interface [nucleotide binding]; other site 935697000973 putative antibiotic binding site [chemical binding]; other site 935697000974 L25 interface [polypeptide binding]; other site 935697000975 L27 interface [polypeptide binding]; other site 935697000976 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 935697000977 putative translocon interaction site; other site 935697000978 23S rRNA interface [nucleotide binding]; other site 935697000979 signal recognition particle (SRP54) interaction site; other site 935697000980 L23 interface [polypeptide binding]; other site 935697000981 trigger factor interaction site; other site 935697000982 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 935697000983 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 935697000984 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 935697000985 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 935697000986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697000987 Walker A/P-loop; other site 935697000988 ATP binding site [chemical binding]; other site 935697000989 Q-loop/lid; other site 935697000990 ABC transporter signature motif; other site 935697000991 Walker B; other site 935697000992 D-loop; other site 935697000993 H-loop/switch region; other site 935697000994 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697000995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697000996 Walker A/P-loop; other site 935697000997 ATP binding site [chemical binding]; other site 935697000998 Q-loop/lid; other site 935697000999 ABC transporter signature motif; other site 935697001000 Walker B; other site 935697001001 D-loop; other site 935697001002 H-loop/switch region; other site 935697001003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697001004 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 935697001005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001006 dimer interface [polypeptide binding]; other site 935697001007 conserved gate region; other site 935697001008 putative PBP binding loops; other site 935697001009 ABC-ATPase subunit interface; other site 935697001010 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697001011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001012 putative PBP binding loops; other site 935697001013 dimer interface [polypeptide binding]; other site 935697001014 ABC-ATPase subunit interface; other site 935697001015 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 935697001016 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 935697001017 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 935697001018 RNA binding site [nucleotide binding]; other site 935697001019 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 935697001020 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 935697001021 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 935697001022 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 935697001023 serine transporter; Region: stp; TIGR00814 935697001024 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 935697001025 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 935697001026 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 935697001027 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 935697001028 active site 935697001029 homotetramer interface [polypeptide binding]; other site 935697001030 homodimer interface [polypeptide binding]; other site 935697001031 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 935697001032 MPT binding site; other site 935697001033 trimer interface [polypeptide binding]; other site 935697001034 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 935697001035 MoaE homodimer interface [polypeptide binding]; other site 935697001036 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935697001037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001038 dimer interface [polypeptide binding]; other site 935697001039 conserved gate region; other site 935697001040 putative PBP binding loops; other site 935697001041 ABC-ATPase subunit interface; other site 935697001042 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 935697001043 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 935697001044 dimer interface [polypeptide binding]; other site 935697001045 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 935697001046 putative functional site; other site 935697001047 putative MPT binding site; other site 935697001048 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 935697001049 dimer interface [polypeptide binding]; other site 935697001050 trimer interface [polypeptide binding]; other site 935697001051 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 935697001052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697001053 FeS/SAM binding site; other site 935697001054 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 935697001055 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 935697001056 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 935697001057 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935697001058 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935697001059 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 935697001060 5S rRNA interface [nucleotide binding]; other site 935697001061 23S rRNA interface [nucleotide binding]; other site 935697001062 L5 interface [polypeptide binding]; other site 935697001063 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 935697001064 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 935697001065 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 935697001066 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 935697001067 23S rRNA binding site [nucleotide binding]; other site 935697001068 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 935697001069 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 935697001070 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 935697001071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001072 dimer interface [polypeptide binding]; other site 935697001073 conserved gate region; other site 935697001074 putative PBP binding loops; other site 935697001075 ABC-ATPase subunit interface; other site 935697001076 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 935697001077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001078 dimer interface [polypeptide binding]; other site 935697001079 conserved gate region; other site 935697001080 putative PBP binding loops; other site 935697001081 ABC-ATPase subunit interface; other site 935697001082 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 935697001083 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 935697001084 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 935697001085 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 935697001086 Walker A/P-loop; other site 935697001087 ATP binding site [chemical binding]; other site 935697001088 Q-loop/lid; other site 935697001089 ABC transporter signature motif; other site 935697001090 Walker B; other site 935697001091 D-loop; other site 935697001092 H-loop/switch region; other site 935697001093 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 935697001094 SecY translocase; Region: SecY; pfam00344 935697001095 adenylate kinase; Reviewed; Region: adk; PRK00279 935697001096 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 935697001097 AMP-binding site [chemical binding]; other site 935697001098 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 935697001099 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 935697001100 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 935697001101 rRNA binding site [nucleotide binding]; other site 935697001102 predicted 30S ribosome binding site; other site 935697001103 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 935697001104 30S ribosomal protein S13; Region: bact_S13; TIGR03631 935697001105 30S ribosomal protein S11; Validated; Region: PRK05309 935697001106 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 935697001107 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 935697001108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697001109 RNA binding surface [nucleotide binding]; other site 935697001110 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 935697001111 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 935697001112 alphaNTD - beta interaction site [polypeptide binding]; other site 935697001113 alphaNTD homodimer interface [polypeptide binding]; other site 935697001114 alphaNTD - beta' interaction site [polypeptide binding]; other site 935697001115 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 935697001116 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 935697001117 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 935697001118 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 935697001119 dimerization interface 3.5A [polypeptide binding]; other site 935697001120 active site 935697001121 Protein of unknown function (DUF690); Region: DUF690; cl04939 935697001122 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 935697001123 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 935697001124 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 935697001125 active site 935697001126 catalytic residues [active] 935697001127 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 935697001128 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 935697001129 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935697001130 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 935697001131 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935697001132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697001133 Walker A/P-loop; other site 935697001134 ATP binding site [chemical binding]; other site 935697001135 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 935697001136 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 935697001137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 935697001138 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 935697001139 23S rRNA interface [nucleotide binding]; other site 935697001140 L3 interface [polypeptide binding]; other site 935697001141 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 935697001142 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 935697001143 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 935697001144 active site 935697001145 substrate binding site [chemical binding]; other site 935697001146 metal binding site [ion binding]; metal-binding site 935697001147 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 935697001148 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 935697001149 alanine racemase; Reviewed; Region: alr; PRK00053 935697001150 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 935697001151 active site 935697001152 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935697001153 dimer interface [polypeptide binding]; other site 935697001154 substrate binding site [chemical binding]; other site 935697001155 catalytic residues [active] 935697001156 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 935697001157 Predicted permease [General function prediction only]; Region: COG2985 935697001158 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 935697001159 TrkA-C domain; Region: TrkA_C; pfam02080 935697001160 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 935697001161 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 935697001162 Glycoprotease family; Region: Peptidase_M22; pfam00814 935697001163 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 935697001164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697001165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 935697001166 Coenzyme A binding pocket [chemical binding]; other site 935697001167 UGMP family protein; Validated; Region: PRK09604 935697001168 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 935697001169 oligomerisation interface [polypeptide binding]; other site 935697001170 mobile loop; other site 935697001171 roof hairpin; other site 935697001172 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 935697001173 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 935697001174 ring oligomerisation interface [polypeptide binding]; other site 935697001175 ATP/Mg binding site [chemical binding]; other site 935697001176 stacking interactions; other site 935697001177 hinge regions; other site 935697001178 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 935697001179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697001180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697001181 DNA binding residues [nucleotide binding] 935697001182 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 935697001183 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935697001184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 935697001185 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 935697001186 active site 935697001187 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 935697001188 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935697001189 phosphate binding site [ion binding]; other site 935697001190 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 935697001191 GMP synthase; Reviewed; Region: guaA; PRK00074 935697001192 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 935697001193 AMP/PPi binding site [chemical binding]; other site 935697001194 candidate oxyanion hole; other site 935697001195 catalytic triad [active] 935697001196 potential glutamine specificity residues [chemical binding]; other site 935697001197 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 935697001198 ATP Binding subdomain [chemical binding]; other site 935697001199 Ligand Binding sites [chemical binding]; other site 935697001200 Dimerization subdomain; other site 935697001201 PspC domain; Region: PspC; cl00864 935697001202 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 935697001203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935697001204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697001205 active site 935697001206 phosphorylation site [posttranslational modification] 935697001207 intermolecular recognition site; other site 935697001208 dimerization interface [polypeptide binding]; other site 935697001209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935697001210 dimerization interface [polypeptide binding]; other site 935697001211 DNA binding residues [nucleotide binding] 935697001212 AMIN domain; Region: AMIN; pfam11741 935697001213 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 935697001214 putative dimer interface [polypeptide binding]; other site 935697001215 putative [2Fe-2S] cluster binding site [ion binding]; other site 935697001216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001217 dimer interface [polypeptide binding]; other site 935697001218 conserved gate region; other site 935697001219 ABC-ATPase subunit interface; other site 935697001220 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 935697001221 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 935697001222 Walker A/P-loop; other site 935697001223 ATP binding site [chemical binding]; other site 935697001224 Q-loop/lid; other site 935697001225 ABC transporter signature motif; other site 935697001226 Walker B; other site 935697001227 D-loop; other site 935697001228 H-loop/switch region; other site 935697001229 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 935697001230 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 935697001231 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 935697001232 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 935697001233 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697001234 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 935697001235 intersubunit interface [polypeptide binding]; other site 935697001236 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 935697001237 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 935697001238 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935697001239 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697001240 ABC-ATPase subunit interface; other site 935697001241 dimer interface [polypeptide binding]; other site 935697001242 putative PBP binding regions; other site 935697001243 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935697001244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 935697001245 dimer interface [polypeptide binding]; other site 935697001246 putative PBP binding regions; other site 935697001247 ABC-ATPase subunit interface; other site 935697001248 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 935697001249 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 935697001250 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 935697001251 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 935697001252 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 935697001253 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 935697001254 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 935697001255 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 935697001256 homodimer interface [polypeptide binding]; other site 935697001257 NADP binding site [chemical binding]; other site 935697001258 substrate binding site [chemical binding]; other site 935697001259 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 935697001260 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 935697001261 active site 935697001262 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 935697001263 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 935697001264 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 935697001265 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697001266 intersubunit interface [polypeptide binding]; other site 935697001267 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697001268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697001269 dimer interface [polypeptide binding]; other site 935697001270 putative PBP binding regions; other site 935697001271 ABC-ATPase subunit interface; other site 935697001272 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 935697001273 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697001274 Walker A/P-loop; other site 935697001275 ATP binding site [chemical binding]; other site 935697001276 Q-loop/lid; other site 935697001277 ABC transporter signature motif; other site 935697001278 Walker B; other site 935697001279 D-loop; other site 935697001280 H-loop/switch region; other site 935697001281 Htaa; Region: HtaA; pfam04213 935697001282 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 935697001283 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935697001284 homodimer interface [polypeptide binding]; other site 935697001285 substrate-cofactor binding pocket; other site 935697001286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697001287 catalytic residue [active] 935697001288 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 935697001289 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 935697001290 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 935697001291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697001292 putative substrate translocation pore; other site 935697001293 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 935697001294 putative catalytic site [active] 935697001295 putative metal binding site [ion binding]; other site 935697001296 putative phosphate binding site [ion binding]; other site 935697001297 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 935697001298 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 935697001299 active site 935697001300 HIGH motif; other site 935697001301 dimer interface [polypeptide binding]; other site 935697001302 KMSKS motif; other site 935697001303 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 935697001304 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 935697001305 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935697001306 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 935697001307 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935697001308 NlpC/P60 family; Region: NLPC_P60; pfam00877 935697001309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697001310 active site 935697001311 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935697001312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935697001313 non-specific DNA binding site [nucleotide binding]; other site 935697001314 salt bridge; other site 935697001315 sequence-specific DNA binding site [nucleotide binding]; other site 935697001316 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 935697001317 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 935697001318 active site 935697001319 substrate binding site [chemical binding]; other site 935697001320 metal binding site [ion binding]; metal-binding site 935697001321 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 935697001322 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 935697001323 metal binding site [ion binding]; metal-binding site 935697001324 putative dimer interface [polypeptide binding]; other site 935697001325 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 935697001326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935697001327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935697001328 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935697001329 pyruvate carboxylase; Reviewed; Region: PRK12999 935697001330 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935697001331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935697001332 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 935697001333 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 935697001334 active site 935697001335 catalytic residues [active] 935697001336 metal binding site [ion binding]; metal-binding site 935697001337 homodimer binding site [polypeptide binding]; other site 935697001338 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935697001339 carboxyltransferase (CT) interaction site; other site 935697001340 biotinylation site [posttranslational modification]; other site 935697001341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935697001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697001344 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 935697001345 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935697001346 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935697001347 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 935697001348 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935697001349 carboxyltransferase (CT) interaction site; other site 935697001350 biotinylation site [posttranslational modification]; other site 935697001351 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 935697001352 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 935697001353 active site residue [active] 935697001354 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 935697001355 active site residue [active] 935697001356 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 935697001357 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 935697001358 Maf-like protein; Region: Maf; pfam02545 935697001359 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935697001360 active site 935697001361 dimer interface [polypeptide binding]; other site 935697001362 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 935697001363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 935697001364 substrate binding site [chemical binding]; other site 935697001365 ATP binding site [chemical binding]; other site 935697001366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 935697001367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 935697001368 DNA binding site [nucleotide binding] 935697001369 domain linker motif; other site 935697001370 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 935697001371 putative ligand binding site [chemical binding]; other site 935697001372 dimerization interface [polypeptide binding]; other site 935697001373 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 935697001374 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 935697001375 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935697001376 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 935697001377 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 935697001378 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935697001379 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 935697001380 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 935697001381 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 935697001382 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 935697001383 ATP-grasp domain; Region: ATP-grasp; pfam02222 935697001384 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 935697001385 Uncharacterized conserved protein [Function unknown]; Region: COG1434 935697001386 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 935697001387 putative active site [active] 935697001388 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 935697001389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001390 dimer interface [polypeptide binding]; other site 935697001391 conserved gate region; other site 935697001392 putative PBP binding loops; other site 935697001393 ABC-ATPase subunit interface; other site 935697001394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001395 dimer interface [polypeptide binding]; other site 935697001396 conserved gate region; other site 935697001397 putative PBP binding loops; other site 935697001398 ABC-ATPase subunit interface; other site 935697001399 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 935697001400 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 935697001401 TIGR03089 family protein; Region: TIGR03089 935697001402 Transcriptional regulator [Transcription]; Region: LytR; COG1316 935697001403 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 935697001404 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 935697001405 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 935697001406 Probable Catalytic site; other site 935697001407 metal-binding site 935697001408 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 935697001409 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 935697001410 active site 935697001411 Substrate binding site; other site 935697001412 Mg++ binding site; other site 935697001413 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935697001414 putative trimer interface [polypeptide binding]; other site 935697001415 putative CoA binding site [chemical binding]; other site 935697001416 Transcription factor WhiB; Region: Whib; pfam02467 935697001417 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 935697001418 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 935697001419 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 935697001420 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 935697001421 active site 935697001422 substrate binding site [chemical binding]; other site 935697001423 metal binding site [ion binding]; metal-binding site 935697001424 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 935697001425 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 935697001426 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 935697001427 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 935697001428 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 935697001429 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 935697001430 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 935697001431 homotetramer interface [polypeptide binding]; other site 935697001432 ligand binding site [chemical binding]; other site 935697001433 catalytic site [active] 935697001434 NAD binding site [chemical binding]; other site 935697001435 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 935697001436 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 935697001437 TMP-binding site; other site 935697001438 ATP-binding site [chemical binding]; other site 935697001439 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935697001440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697001441 active site 935697001442 phosphorylation site [posttranslational modification] 935697001443 intermolecular recognition site; other site 935697001444 dimerization interface [polypeptide binding]; other site 935697001445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935697001446 DNA binding site [nucleotide binding] 935697001447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935697001448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935697001449 dimerization interface [polypeptide binding]; other site 935697001450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935697001451 dimer interface [polypeptide binding]; other site 935697001452 phosphorylation site [posttranslational modification] 935697001453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697001454 ATP binding site [chemical binding]; other site 935697001455 Mg2+ binding site [ion binding]; other site 935697001456 G-X-G motif; other site 935697001457 lipoprotein LpqB; Provisional; Region: PRK13616 935697001458 Sporulation and spore germination; Region: Germane; pfam10646 935697001459 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 935697001460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697001461 active site 935697001462 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 935697001463 30S subunit binding site; other site 935697001464 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 935697001465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 935697001466 ATP binding site [chemical binding]; other site 935697001467 putative Mg++ binding site [ion binding]; other site 935697001468 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 935697001469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 935697001470 nucleotide binding region [chemical binding]; other site 935697001471 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 935697001472 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 935697001473 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 935697001474 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 935697001475 putative di-iron ligands [ion binding]; other site 935697001476 Predicted GTPases [General function prediction only]; Region: COG1162 935697001477 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 935697001478 GTPase/Zn-binding domain interface [polypeptide binding]; other site 935697001479 GTP/Mg2+ binding site [chemical binding]; other site 935697001480 G4 box; other site 935697001481 G5 box; other site 935697001482 G1 box; other site 935697001483 Switch I region; other site 935697001484 G2 box; other site 935697001485 G3 box; other site 935697001486 Switch II region; other site 935697001487 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 935697001488 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 935697001489 active site 935697001490 hinge; other site 935697001491 Uncharacterized conserved protein [Function unknown]; Region: COG2135 935697001492 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 935697001493 putative deacylase active site [active] 935697001494 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 935697001495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697001496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697001497 DNA binding residues [nucleotide binding] 935697001498 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 935697001499 Transcription factor WhiB; Region: Whib; pfam02467 935697001500 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 935697001501 active site 935697001502 catalytic triad [active] 935697001503 oxyanion hole [active] 935697001504 PQQ-like domain; Region: PQQ_2; pfam13360 935697001505 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935697001506 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935697001507 ATP binding site [chemical binding]; other site 935697001508 Mg++ binding site [ion binding]; other site 935697001509 motif III; other site 935697001510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697001511 nucleotide binding region [chemical binding]; other site 935697001512 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 935697001513 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 935697001514 TIGR02569 family protein; Region: TIGR02569_actnb 935697001515 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 935697001516 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 935697001517 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 935697001518 Part of AAA domain; Region: AAA_19; pfam13245 935697001519 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 935697001520 Ion channel; Region: Ion_trans_2; pfam07885 935697001521 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 935697001522 TrkA-N domain; Region: TrkA_N; pfam02254 935697001523 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 935697001524 putative NADH binding site [chemical binding]; other site 935697001525 putative active site [active] 935697001526 nudix motif; other site 935697001527 putative metal binding site [ion binding]; other site 935697001528 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 935697001529 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 935697001530 Family description; Region: UvrD_C_2; pfam13538 935697001531 HRDC domain; Region: HRDC; pfam00570 935697001532 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 935697001533 Protein of unknown function DUF45; Region: DUF45; cl00636 935697001534 putative hydrolase; Region: TIGR03624 935697001535 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 935697001536 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935697001537 hypothetical protein; Validated; Region: PRK00068 935697001538 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 935697001539 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 935697001540 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 935697001541 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 935697001542 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 935697001543 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 935697001544 Predicted membrane protein [Function unknown]; Region: COG2311 935697001545 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 935697001546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697001547 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 935697001548 acyl-activating enzyme (AAE) consensus motif; other site 935697001549 AMP binding site [chemical binding]; other site 935697001550 active site 935697001551 CoA binding site [chemical binding]; other site 935697001552 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 935697001553 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 935697001554 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935697001555 putative trimer interface [polypeptide binding]; other site 935697001556 putative CoA binding site [chemical binding]; other site 935697001557 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935697001558 putative trimer interface [polypeptide binding]; other site 935697001559 putative CoA binding site [chemical binding]; other site 935697001560 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 935697001561 oxaloacetate decarboxylase; Provisional; Region: PRK12330 935697001562 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 935697001563 active site 935697001564 catalytic residues [active] 935697001565 metal binding site [ion binding]; metal-binding site 935697001566 homodimer binding site [polypeptide binding]; other site 935697001567 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 935697001568 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935697001569 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 935697001570 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935697001571 carboxyltransferase (CT) interaction site; other site 935697001572 biotinylation site [posttranslational modification]; other site 935697001573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935697001574 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 935697001575 active site 935697001576 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 935697001577 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935697001578 active site 935697001579 peptide chain release factor 2; Validated; Region: prfB; PRK00578 935697001580 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935697001581 RF-1 domain; Region: RF-1; pfam00472 935697001582 topology modulation protein; Provisional; Region: PRK07261 935697001583 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 935697001584 active site 935697001585 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 935697001586 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 935697001587 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 935697001588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697001589 Walker A/P-loop; other site 935697001590 ATP binding site [chemical binding]; other site 935697001591 Q-loop/lid; other site 935697001592 ABC transporter signature motif; other site 935697001593 Walker B; other site 935697001594 D-loop; other site 935697001595 H-loop/switch region; other site 935697001596 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 935697001597 FtsX-like permease family; Region: FtsX; pfam02687 935697001598 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 935697001599 SmpB-tmRNA interface; other site 935697001600 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 935697001601 active site clefts [active] 935697001602 zinc binding site [ion binding]; other site 935697001603 dimer interface [polypeptide binding]; other site 935697001604 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935697001605 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697001606 intersubunit interface [polypeptide binding]; other site 935697001607 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697001608 ABC-ATPase subunit interface; other site 935697001609 dimer interface [polypeptide binding]; other site 935697001610 putative PBP binding regions; other site 935697001611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697001612 ABC-ATPase subunit interface; other site 935697001613 dimer interface [polypeptide binding]; other site 935697001614 putative PBP binding regions; other site 935697001615 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 935697001616 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697001617 Walker A/P-loop; other site 935697001618 ATP binding site [chemical binding]; other site 935697001619 Q-loop/lid; other site 935697001620 ABC transporter signature motif; other site 935697001621 Walker B; other site 935697001622 D-loop; other site 935697001623 H-loop/switch region; other site 935697001624 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 935697001625 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 935697001626 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 935697001627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697001628 ATP binding site [chemical binding]; other site 935697001629 putative Mg++ binding site [ion binding]; other site 935697001630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697001631 nucleotide binding region [chemical binding]; other site 935697001632 ATP-binding site [chemical binding]; other site 935697001633 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 935697001634 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 935697001635 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 935697001636 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 935697001637 DNA-binding site [nucleotide binding]; DNA binding site 935697001638 RNA-binding motif; other site 935697001639 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 935697001640 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 935697001641 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 935697001642 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935697001643 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935697001644 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 935697001645 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 935697001646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935697001647 catalytic residue [active] 935697001648 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 935697001649 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935697001650 dimer interface [polypeptide binding]; other site 935697001651 active site 935697001652 citrylCoA binding site [chemical binding]; other site 935697001653 NADH binding [chemical binding]; other site 935697001654 cationic pore residues; other site 935697001655 oxalacetate/citrate binding site [chemical binding]; other site 935697001656 coenzyme A binding site [chemical binding]; other site 935697001657 catalytic triad [active] 935697001658 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935697001659 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 935697001660 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 935697001661 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 935697001662 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 935697001663 E-class dimer interface [polypeptide binding]; other site 935697001664 P-class dimer interface [polypeptide binding]; other site 935697001665 active site 935697001666 Cu2+ binding site [ion binding]; other site 935697001667 Zn2+ binding site [ion binding]; other site 935697001668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 935697001669 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 935697001670 active site 935697001671 catalytic tetrad [active] 935697001672 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 935697001673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 935697001674 substrate binding site [chemical binding]; other site 935697001675 oxyanion hole (OAH) forming residues; other site 935697001676 trimer interface [polypeptide binding]; other site 935697001677 Protein of unknown function, DUF485; Region: DUF485; pfam04341 935697001678 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 935697001679 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 935697001680 Na binding site [ion binding]; other site 935697001681 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935697001682 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 935697001683 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 935697001684 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 935697001685 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 935697001686 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 935697001687 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 935697001688 multidrug efflux protein NorA; Provisional; Region: PRK00187 935697001689 cation binding site [ion binding]; other site 935697001690 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 935697001691 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 935697001692 dimer interface [polypeptide binding]; other site 935697001693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697001694 catalytic residue [active] 935697001695 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 935697001696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935697001697 catalytic residue [active] 935697001698 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 935697001699 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 935697001700 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 935697001701 substrate binding pocket [chemical binding]; other site 935697001702 active site 935697001703 iron coordination sites [ion binding]; other site 935697001704 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 935697001705 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 935697001706 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697001707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001708 dimer interface [polypeptide binding]; other site 935697001709 conserved gate region; other site 935697001710 putative PBP binding loops; other site 935697001711 ABC-ATPase subunit interface; other site 935697001712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 935697001713 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 935697001714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697001715 Walker A/P-loop; other site 935697001716 ATP binding site [chemical binding]; other site 935697001717 Q-loop/lid; other site 935697001718 ABC transporter signature motif; other site 935697001719 Walker B; other site 935697001720 D-loop; other site 935697001721 H-loop/switch region; other site 935697001722 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697001723 Walker A/P-loop; other site 935697001724 ATP binding site [chemical binding]; other site 935697001725 Q-loop/lid; other site 935697001726 ABC transporter signature motif; other site 935697001727 Walker B; other site 935697001728 D-loop; other site 935697001729 H-loop/switch region; other site 935697001730 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 935697001731 active site 935697001732 SAM binding site [chemical binding]; other site 935697001733 homodimer interface [polypeptide binding]; other site 935697001734 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 935697001735 catalytic residues [active] 935697001736 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 935697001737 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 935697001738 folate binding site [chemical binding]; other site 935697001739 NADP+ binding site [chemical binding]; other site 935697001740 thymidylate synthase; Reviewed; Region: thyA; PRK01827 935697001741 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 935697001742 dimerization interface [polypeptide binding]; other site 935697001743 active site 935697001744 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 935697001745 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935697001746 active site 935697001747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697001748 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 935697001749 ATP binding site [chemical binding]; other site 935697001750 putative Mg++ binding site [ion binding]; other site 935697001751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697001752 nucleotide binding region [chemical binding]; other site 935697001753 ATP-binding site [chemical binding]; other site 935697001754 DEAD/H associated; Region: DEAD_assoc; pfam08494 935697001755 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 935697001756 active site 935697001757 SUMO-1 interface [polypeptide binding]; other site 935697001758 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 935697001759 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 935697001760 putative DNA binding site [nucleotide binding]; other site 935697001761 putative catalytic residues [active] 935697001762 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 935697001763 hypothetical protein; Provisional; Region: PRK11770 935697001764 Domain of unknown function (DUF307); Region: DUF307; pfam03733 935697001765 Domain of unknown function (DUF307); Region: DUF307; pfam03733 935697001766 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935697001767 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935697001768 active site 935697001769 dimer interface [polypeptide binding]; other site 935697001770 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935697001771 dimer interface [polypeptide binding]; other site 935697001772 active site 935697001773 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935697001774 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 935697001775 tetramerization interface [polypeptide binding]; other site 935697001776 NAD(P) binding site [chemical binding]; other site 935697001777 catalytic residues [active] 935697001778 hypothetical protein; Provisional; Region: PRK07857 935697001779 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 935697001780 Part of AAA domain; Region: AAA_19; pfam13245 935697001781 Family description; Region: UvrD_C_2; pfam13538 935697001782 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 935697001783 Peptidase family M23; Region: Peptidase_M23; pfam01551 935697001784 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 935697001785 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 935697001786 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 935697001787 active site 935697001788 substrate binding site [chemical binding]; other site 935697001789 cosubstrate binding site; other site 935697001790 catalytic site [active] 935697001791 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 935697001792 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 935697001793 purine monophosphate binding site [chemical binding]; other site 935697001794 dimer interface [polypeptide binding]; other site 935697001795 putative catalytic residues [active] 935697001796 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 935697001797 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935697001798 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935697001799 Walker A/P-loop; other site 935697001800 ATP binding site [chemical binding]; other site 935697001801 Q-loop/lid; other site 935697001802 ABC transporter signature motif; other site 935697001803 Walker B; other site 935697001804 D-loop; other site 935697001805 H-loop/switch region; other site 935697001806 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 935697001807 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935697001808 substrate binding pocket [chemical binding]; other site 935697001809 membrane-bound complex binding site; other site 935697001810 hinge residues; other site 935697001811 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 935697001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001813 dimer interface [polypeptide binding]; other site 935697001814 conserved gate region; other site 935697001815 putative PBP binding loops; other site 935697001816 ABC-ATPase subunit interface; other site 935697001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697001818 dimer interface [polypeptide binding]; other site 935697001819 conserved gate region; other site 935697001820 putative PBP binding loops; other site 935697001821 ABC-ATPase subunit interface; other site 935697001822 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 935697001823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697001824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697001825 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 935697001826 30S ribosomal protein S18; Provisional; Region: PRK13401 935697001827 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 935697001828 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 935697001829 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 935697001830 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 935697001831 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 935697001832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935697001833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697001834 active site 935697001835 phosphorylation site [posttranslational modification] 935697001836 intermolecular recognition site; other site 935697001837 dimerization interface [polypeptide binding]; other site 935697001838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935697001839 DNA binding site [nucleotide binding] 935697001840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935697001841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935697001842 dimerization interface [polypeptide binding]; other site 935697001843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935697001844 dimer interface [polypeptide binding]; other site 935697001845 phosphorylation site [posttranslational modification] 935697001846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697001847 ATP binding site [chemical binding]; other site 935697001848 Mg2+ binding site [ion binding]; other site 935697001849 G-X-G motif; other site 935697001850 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 935697001851 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 935697001852 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935697001853 protein binding site [polypeptide binding]; other site 935697001854 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 935697001855 MPT binding site; other site 935697001856 trimer interface [polypeptide binding]; other site 935697001857 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 935697001858 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 935697001859 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 935697001860 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 935697001861 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 935697001862 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 935697001863 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 935697001864 active site 935697001865 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 935697001866 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 935697001867 dimer interface [polypeptide binding]; other site 935697001868 putative functional site; other site 935697001869 putative MPT binding site; other site 935697001870 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 935697001871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 935697001872 Predicted membrane protein [Function unknown]; Region: COG2259 935697001873 Predicted integral membrane protein [Function unknown]; Region: COG5660 935697001874 Putative zinc-finger; Region: zf-HC2; pfam13490 935697001875 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 935697001876 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 935697001877 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 935697001878 BCCT family transporter; Region: BCCT; pfam02028 935697001879 Uncharacterized membrane protein [Function unknown]; Region: COG3949 935697001880 Predicted methyltransferases [General function prediction only]; Region: COG0313 935697001881 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 935697001882 putative SAM binding site [chemical binding]; other site 935697001883 putative homodimer interface [polypeptide binding]; other site 935697001884 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 935697001885 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 935697001886 active site 935697001887 HIGH motif; other site 935697001888 KMSKS motif; other site 935697001889 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 935697001890 tRNA binding surface [nucleotide binding]; other site 935697001891 anticodon binding site; other site 935697001892 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935697001893 active site 935697001894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 935697001895 Domain of unknown function (DUF348); Region: DUF348; pfam03990 935697001896 Domain of unknown function (DUF348); Region: DUF348; pfam03990 935697001897 G5 domain; Region: G5; pfam07501 935697001898 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 935697001899 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 935697001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697001901 S-adenosylmethionine binding site [chemical binding]; other site 935697001902 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 935697001903 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 935697001904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697001905 ABC transporter; Region: ABC_tran_2; pfam12848 935697001906 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697001907 Uncharacterized conserved protein [Function unknown]; Region: COG1359 935697001908 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 935697001909 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 935697001910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697001911 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 935697001912 active site 935697001913 motif I; other site 935697001914 motif II; other site 935697001915 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935697001916 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 935697001917 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935697001918 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935697001919 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 935697001920 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 935697001921 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 935697001922 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 935697001923 G1 box; other site 935697001924 putative GEF interaction site [polypeptide binding]; other site 935697001925 GTP/Mg2+ binding site [chemical binding]; other site 935697001926 Switch I region; other site 935697001927 G2 box; other site 935697001928 G3 box; other site 935697001929 Switch II region; other site 935697001930 G4 box; other site 935697001931 G5 box; other site 935697001932 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 935697001933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697001934 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 935697001935 NAD(P) binding site [chemical binding]; other site 935697001936 active site 935697001937 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 935697001938 putative active site [active] 935697001939 catalytic residue [active] 935697001940 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 935697001941 FMN binding site [chemical binding]; other site 935697001942 substrate binding site [chemical binding]; other site 935697001943 putative catalytic residue [active] 935697001944 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 935697001945 putative active site [active] 935697001946 catalytic residue [active] 935697001947 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 935697001948 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 935697001949 5S rRNA interface [nucleotide binding]; other site 935697001950 CTC domain interface [polypeptide binding]; other site 935697001951 L16 interface [polypeptide binding]; other site 935697001952 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 935697001953 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 935697001954 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697001955 active site 935697001956 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 935697001957 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 935697001958 Substrate binding site; other site 935697001959 Mg++ binding site; other site 935697001960 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 935697001961 active site 935697001962 substrate binding site [chemical binding]; other site 935697001963 CoA binding site [chemical binding]; other site 935697001964 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 935697001965 gating phenylalanine in ion channel; other site 935697001966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697001967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697001968 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 935697001969 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 935697001970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697001971 ATP binding site [chemical binding]; other site 935697001972 putative Mg++ binding site [ion binding]; other site 935697001973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697001974 nucleotide binding region [chemical binding]; other site 935697001975 ATP-binding site [chemical binding]; other site 935697001976 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 935697001977 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 935697001978 Spore germination protein; Region: Spore_permease; cl17796 935697001979 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935697001980 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935697001981 enolase; Provisional; Region: eno; PRK00077 935697001982 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 935697001983 dimer interface [polypeptide binding]; other site 935697001984 metal binding site [ion binding]; metal-binding site 935697001985 substrate binding pocket [chemical binding]; other site 935697001986 Septum formation initiator; Region: DivIC; pfam04977 935697001987 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 935697001988 Uncharacterized conserved protein [Function unknown]; Region: COG1507 935697001989 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 935697001990 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 935697001991 Helix-turn-helix domain; Region: HTH_18; pfam12833 935697001992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 935697001993 Bax inhibitor 1 like; Region: BaxI_1; cl17691 935697001994 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 935697001995 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935697001996 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935697001997 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 935697001998 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 935697001999 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 935697002000 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 935697002001 catalytic residue [active] 935697002002 putative FPP diphosphate binding site; other site 935697002003 putative FPP binding hydrophobic cleft; other site 935697002004 dimer interface [polypeptide binding]; other site 935697002005 putative IPP diphosphate binding site; other site 935697002006 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 935697002007 pantothenate kinase; Provisional; Region: PRK05439 935697002008 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 935697002009 ATP-binding site [chemical binding]; other site 935697002010 CoA-binding site [chemical binding]; other site 935697002011 Mg2+-binding site [ion binding]; other site 935697002012 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 935697002013 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 935697002014 dimer interface [polypeptide binding]; other site 935697002015 active site 935697002016 glycine-pyridoxal phosphate binding site [chemical binding]; other site 935697002017 folate binding site [chemical binding]; other site 935697002018 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935697002019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002020 putative substrate translocation pore; other site 935697002021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697002022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697002023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935697002024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 935697002025 dimerization interface [polypeptide binding]; other site 935697002026 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 935697002027 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 935697002028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697002029 Coenzyme A binding pocket [chemical binding]; other site 935697002030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002031 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 935697002032 putative substrate translocation pore; other site 935697002033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697002035 fumarate hydratase; Reviewed; Region: fumC; PRK00485 935697002036 Class II fumarases; Region: Fumarase_classII; cd01362 935697002037 active site 935697002038 tetramer interface [polypeptide binding]; other site 935697002039 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 935697002040 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 935697002041 putative active site [active] 935697002042 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 935697002043 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 935697002044 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 935697002045 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 935697002046 generic binding surface II; other site 935697002047 generic binding surface I; other site 935697002048 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 935697002049 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 935697002050 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 935697002051 Domain of unknown function DUF20; Region: UPF0118; pfam01594 935697002052 GTP-binding protein YchF; Reviewed; Region: PRK09601 935697002053 YchF GTPase; Region: YchF; cd01900 935697002054 G1 box; other site 935697002055 GTP/Mg2+ binding site [chemical binding]; other site 935697002056 Switch I region; other site 935697002057 G2 box; other site 935697002058 Switch II region; other site 935697002059 G3 box; other site 935697002060 G4 box; other site 935697002061 G5 box; other site 935697002062 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 935697002063 Protein of unknown function, DUF488; Region: DUF488; pfam04343 935697002064 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 935697002065 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 935697002066 PhnA protein; Region: PhnA; pfam03831 935697002067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 935697002068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935697002069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002070 Walker A/P-loop; other site 935697002071 ATP binding site [chemical binding]; other site 935697002072 Q-loop/lid; other site 935697002073 ABC transporter signature motif; other site 935697002074 Walker B; other site 935697002075 D-loop; other site 935697002076 H-loop/switch region; other site 935697002077 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 935697002078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935697002079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002080 Walker A/P-loop; other site 935697002081 ATP binding site [chemical binding]; other site 935697002082 Q-loop/lid; other site 935697002083 ABC transporter signature motif; other site 935697002084 Walker B; other site 935697002085 D-loop; other site 935697002086 H-loop/switch region; other site 935697002087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002088 Walker A/P-loop; other site 935697002089 ATP binding site [chemical binding]; other site 935697002090 Q-loop/lid; other site 935697002091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935697002092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002093 Walker A/P-loop; other site 935697002094 ATP binding site [chemical binding]; other site 935697002095 Q-loop/lid; other site 935697002096 ABC transporter; Region: ABC_tran; pfam00005 935697002097 ABC transporter signature motif; other site 935697002098 Walker B; other site 935697002099 D-loop; other site 935697002100 H-loop/switch region; other site 935697002101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 935697002102 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 935697002103 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 935697002104 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 935697002105 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 935697002106 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 935697002107 hypothetical protein; Provisional; Region: PRK06547 935697002108 AAA domain; Region: AAA_18; pfam13238 935697002109 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 935697002110 nudix motif; other site 935697002111 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 935697002112 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 935697002113 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697002114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697002115 dimer interface [polypeptide binding]; other site 935697002116 conserved gate region; other site 935697002117 ABC-ATPase subunit interface; other site 935697002118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 935697002119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697002120 dimer interface [polypeptide binding]; other site 935697002121 conserved gate region; other site 935697002122 putative PBP binding loops; other site 935697002123 ABC-ATPase subunit interface; other site 935697002124 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 935697002125 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697002126 Walker A/P-loop; other site 935697002127 ATP binding site [chemical binding]; other site 935697002128 Q-loop/lid; other site 935697002129 ABC transporter signature motif; other site 935697002130 Walker B; other site 935697002131 D-loop; other site 935697002132 H-loop/switch region; other site 935697002133 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697002134 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697002135 Walker A/P-loop; other site 935697002136 ATP binding site [chemical binding]; other site 935697002137 Q-loop/lid; other site 935697002138 ABC transporter signature motif; other site 935697002139 Walker B; other site 935697002140 D-loop; other site 935697002141 H-loop/switch region; other site 935697002142 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697002143 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 935697002144 cleavage site 935697002145 active site 935697002146 substrate binding sites [chemical binding]; other site 935697002147 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 935697002148 ArsC family; Region: ArsC; pfam03960 935697002149 catalytic residues [active] 935697002150 Protein of unknown function (DUF402); Region: DUF402; cl00979 935697002151 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 935697002152 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 935697002153 G1 box; other site 935697002154 GTP/Mg2+ binding site [chemical binding]; other site 935697002155 G2 box; other site 935697002156 Switch I region; other site 935697002157 G3 box; other site 935697002158 Switch II region; other site 935697002159 G4 box; other site 935697002160 G5 box; other site 935697002161 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 935697002162 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 935697002163 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 935697002164 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 935697002165 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 935697002166 Ferredoxin [Energy production and conversion]; Region: COG1146 935697002167 4Fe-4S binding domain; Region: Fer4; pfam00037 935697002168 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 935697002169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697002170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697002171 homodimer interface [polypeptide binding]; other site 935697002172 catalytic residue [active] 935697002173 Predicted membrane protein [Function unknown]; Region: COG2246 935697002174 GtrA-like protein; Region: GtrA; pfam04138 935697002175 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 935697002176 active site 935697002177 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 935697002178 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 935697002179 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 935697002180 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 935697002181 putative trimer interface [polypeptide binding]; other site 935697002182 putative CoA binding site [chemical binding]; other site 935697002183 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 935697002184 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 935697002185 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 935697002186 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935697002187 putative trimer interface [polypeptide binding]; other site 935697002188 putative CoA binding site [chemical binding]; other site 935697002189 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 935697002190 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 935697002191 metal binding site [ion binding]; metal-binding site 935697002192 putative dimer interface [polypeptide binding]; other site 935697002193 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 935697002194 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 935697002195 dihydropteroate synthase; Region: DHPS; TIGR01496 935697002196 substrate binding pocket [chemical binding]; other site 935697002197 dimer interface [polypeptide binding]; other site 935697002198 inhibitor binding site; inhibition site 935697002199 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935697002200 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 935697002201 Ligand binding site; other site 935697002202 Putative Catalytic site; other site 935697002203 DXD motif; other site 935697002204 DivIVA domain; Region: DivI1A_domain; TIGR03544 935697002205 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 935697002206 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 935697002207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002208 S-adenosylmethionine binding site [chemical binding]; other site 935697002209 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 935697002210 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 935697002211 active site 935697002212 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 935697002213 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 935697002214 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 935697002215 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935697002216 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 935697002217 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 935697002218 ligand binding site; other site 935697002219 oligomer interface; other site 935697002220 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 935697002221 dimer interface [polypeptide binding]; other site 935697002222 N-terminal domain interface [polypeptide binding]; other site 935697002223 sulfate 1 binding site; other site 935697002224 Methyltransferase domain; Region: Methyltransf_24; pfam13578 935697002225 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 935697002226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697002227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697002228 DNA binding residues [nucleotide binding] 935697002229 sec-independent translocase; Provisional; Region: tatB; PRK00182 935697002230 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 935697002231 Domain of unknown function DUF59; Region: DUF59; pfam01883 935697002232 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 935697002233 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 935697002234 Predicted membrane protein [Function unknown]; Region: COG4420 935697002235 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 935697002236 MgtE intracellular N domain; Region: MgtE_N; smart00924 935697002237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 935697002238 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 935697002239 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 935697002240 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935697002241 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 935697002242 TPP-binding site [chemical binding]; other site 935697002243 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 935697002244 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 935697002245 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935697002246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002247 Walker A/P-loop; other site 935697002248 ATP binding site [chemical binding]; other site 935697002249 Q-loop/lid; other site 935697002250 ABC transporter signature motif; other site 935697002251 Walker B; other site 935697002252 D-loop; other site 935697002253 H-loop/switch region; other site 935697002254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 935697002255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935697002256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002257 Walker A/P-loop; other site 935697002258 ATP binding site [chemical binding]; other site 935697002259 Q-loop/lid; other site 935697002260 ABC transporter signature motif; other site 935697002261 Walker B; other site 935697002262 D-loop; other site 935697002263 H-loop/switch region; other site 935697002264 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 935697002265 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 935697002266 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 935697002267 shikimate binding site; other site 935697002268 NAD(P) binding site [chemical binding]; other site 935697002269 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 935697002270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 935697002271 substrate binding pocket [chemical binding]; other site 935697002272 catalytic triad [active] 935697002273 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 935697002274 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 935697002275 active site 935697002276 catalytic residues [active] 935697002277 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 935697002278 putative transporter; Provisional; Region: PRK10484 935697002279 Na binding site [ion binding]; other site 935697002280 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 935697002281 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 935697002282 nucleotide binding site/active site [active] 935697002283 HIT family signature motif; other site 935697002284 catalytic residue [active] 935697002285 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 935697002286 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 935697002287 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 935697002288 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 935697002289 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935697002290 ATP binding site [chemical binding]; other site 935697002291 Mg++ binding site [ion binding]; other site 935697002292 motif III; other site 935697002293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697002294 nucleotide binding region [chemical binding]; other site 935697002295 ATP-binding site [chemical binding]; other site 935697002296 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 935697002297 putative RNA binding site [nucleotide binding]; other site 935697002298 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 935697002299 dimer interface [polypeptide binding]; other site 935697002300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935697002301 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 935697002302 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 935697002303 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 935697002304 Na binding site [ion binding]; other site 935697002305 SNF2 Helicase protein; Region: DUF3670; pfam12419 935697002306 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 935697002307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697002308 ATP binding site [chemical binding]; other site 935697002309 putative Mg++ binding site [ion binding]; other site 935697002310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697002311 nucleotide binding region [chemical binding]; other site 935697002312 ATP-binding site [chemical binding]; other site 935697002313 Uncharacterized conserved protein [Function unknown]; Region: COG4279 935697002314 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 935697002315 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 935697002316 active site 935697002317 metal binding site [ion binding]; metal-binding site 935697002318 DNA binding site [nucleotide binding] 935697002319 AAA domain; Region: AAA_23; pfam13476 935697002320 Uncharacterized conserved protein [Function unknown]; Region: COG2353 935697002321 Transcriptional regulators [Transcription]; Region: MarR; COG1846 935697002322 MarR family; Region: MarR_2; pfam12802 935697002323 PspC domain; Region: PspC; pfam04024 935697002324 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 935697002325 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 935697002326 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 935697002327 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 935697002328 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935697002329 Cysteine-rich domain; Region: CCG; pfam02754 935697002330 Cysteine-rich domain; Region: CCG; pfam02754 935697002331 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 935697002332 L-lactate permease; Region: Lactate_perm; cl00701 935697002333 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 935697002334 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 935697002335 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 935697002336 active site 935697002337 HIGH motif; other site 935697002338 KMSK motif region; other site 935697002339 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 935697002340 tRNA binding surface [nucleotide binding]; other site 935697002341 anticodon binding site; other site 935697002342 diaminopimelate decarboxylase; Region: lysA; TIGR01048 935697002343 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 935697002344 active site 935697002345 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935697002346 substrate binding site [chemical binding]; other site 935697002347 catalytic residues [active] 935697002348 dimer interface [polypeptide binding]; other site 935697002349 homoserine dehydrogenase; Provisional; Region: PRK06349 935697002350 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 935697002351 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 935697002352 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 935697002353 homoserine kinase; Provisional; Region: PRK01212 935697002354 Predicted transcriptional regulator [Transcription]; Region: COG2345 935697002355 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 935697002356 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 935697002357 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697002358 acyl-activating enzyme (AAE) consensus motif; other site 935697002359 AMP binding site [chemical binding]; other site 935697002360 active site 935697002361 CoA binding site [chemical binding]; other site 935697002362 peptide chain release factor 1; Validated; Region: prfA; PRK00591 935697002363 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935697002364 RF-1 domain; Region: RF-1; pfam00472 935697002365 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 935697002366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002367 S-adenosylmethionine binding site [chemical binding]; other site 935697002368 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 935697002369 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 935697002370 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 935697002371 Mg++ binding site [ion binding]; other site 935697002372 putative catalytic motif [active] 935697002373 substrate binding site [chemical binding]; other site 935697002374 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 935697002375 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 935697002376 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 935697002377 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 935697002378 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 935697002379 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 935697002380 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 935697002381 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935697002382 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 935697002383 beta subunit interaction interface [polypeptide binding]; other site 935697002384 Walker A motif; other site 935697002385 ATP binding site [chemical binding]; other site 935697002386 Walker B motif; other site 935697002387 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935697002388 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 935697002389 core domain interface [polypeptide binding]; other site 935697002390 delta subunit interface [polypeptide binding]; other site 935697002391 epsilon subunit interface [polypeptide binding]; other site 935697002392 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 935697002393 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935697002394 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 935697002395 alpha subunit interaction interface [polypeptide binding]; other site 935697002396 Walker A motif; other site 935697002397 ATP binding site [chemical binding]; other site 935697002398 Walker B motif; other site 935697002399 inhibitor binding site; inhibition site 935697002400 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935697002401 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 935697002402 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 935697002403 gamma subunit interface [polypeptide binding]; other site 935697002404 epsilon subunit interface [polypeptide binding]; other site 935697002405 LBP interface [polypeptide binding]; other site 935697002406 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 935697002407 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 935697002408 hypothetical protein; Provisional; Region: PRK03298 935697002409 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 935697002410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935697002411 dimer interface [polypeptide binding]; other site 935697002412 substrate binding site [chemical binding]; other site 935697002413 metal binding site [ion binding]; metal-binding site 935697002414 Domain of unknown function DUF77; Region: DUF77; pfam01910 935697002415 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 935697002416 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 935697002417 glycogen branching enzyme; Provisional; Region: PRK05402 935697002418 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 935697002419 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 935697002420 active site 935697002421 catalytic site [active] 935697002422 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 935697002423 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 935697002424 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 935697002425 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 935697002426 active site 935697002427 catalytic site [active] 935697002428 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 935697002429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697002430 Walker A/P-loop; other site 935697002431 ATP binding site [chemical binding]; other site 935697002432 ABC transporter signature motif; other site 935697002433 Walker B; other site 935697002434 D-loop; other site 935697002435 H-loop/switch region; other site 935697002436 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 935697002437 Ligand binding site [chemical binding]; other site 935697002438 Electron transfer flavoprotein domain; Region: ETF; pfam01012 935697002439 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 935697002440 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 935697002441 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 935697002442 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 935697002443 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 935697002444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935697002445 catalytic residue [active] 935697002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002447 S-adenosylmethionine binding site [chemical binding]; other site 935697002448 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 935697002449 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 935697002450 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 935697002451 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 935697002452 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 935697002453 active site 935697002454 catalytic site [active] 935697002455 substrate binding site [chemical binding]; other site 935697002456 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 935697002457 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 935697002458 nucleotide binding pocket [chemical binding]; other site 935697002459 K-X-D-G motif; other site 935697002460 catalytic site [active] 935697002461 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 935697002462 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 935697002463 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 935697002464 Dimer interface [polypeptide binding]; other site 935697002465 BRCT sequence motif; other site 935697002466 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 935697002467 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 935697002468 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 935697002469 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 935697002470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 935697002471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935697002473 putative substrate translocation pore; other site 935697002474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002475 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697002476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697002477 ABC-ATPase subunit interface; other site 935697002478 dimer interface [polypeptide binding]; other site 935697002479 putative PBP binding regions; other site 935697002480 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697002481 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 935697002482 Walker A/P-loop; other site 935697002483 ATP binding site [chemical binding]; other site 935697002484 Q-loop/lid; other site 935697002485 ABC transporter signature motif; other site 935697002486 Walker B; other site 935697002487 D-loop; other site 935697002488 H-loop/switch region; other site 935697002489 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 935697002490 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 935697002491 putative ligand binding residues [chemical binding]; other site 935697002492 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 935697002493 phosphofructokinase; Region: PFK_mixed; TIGR02483 935697002494 active site 935697002495 ADP/pyrophosphate binding site [chemical binding]; other site 935697002496 dimerization interface [polypeptide binding]; other site 935697002497 allosteric effector site; other site 935697002498 fructose-1,6-bisphosphate binding site; other site 935697002499 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 935697002500 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 935697002501 GatB domain; Region: GatB_Yqey; smart00845 935697002502 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 935697002503 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 935697002504 active site 935697002505 catalytic tetrad [active] 935697002506 Lysine efflux permease [General function prediction only]; Region: COG1279 935697002507 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 935697002508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935697002509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 935697002510 dimerization interface [polypeptide binding]; other site 935697002511 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 935697002512 Predicted membrane protein [Function unknown]; Region: COG2259 935697002513 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 935697002514 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 935697002515 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935697002516 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935697002517 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 935697002518 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 935697002519 PYR/PP interface [polypeptide binding]; other site 935697002520 dimer interface [polypeptide binding]; other site 935697002521 TPP binding site [chemical binding]; other site 935697002522 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 935697002523 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 935697002524 TPP-binding site [chemical binding]; other site 935697002525 dimer interface [polypeptide binding]; other site 935697002526 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 935697002527 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 935697002528 putative valine binding site [chemical binding]; other site 935697002529 dimer interface [polypeptide binding]; other site 935697002530 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 935697002531 ketol-acid reductoisomerase; Provisional; Region: PRK05479 935697002532 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 935697002533 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 935697002534 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 935697002535 Uncharacterized conserved protein [Function unknown]; Region: COG1479 935697002536 Protein of unknown function DUF262; Region: DUF262; pfam03235 935697002537 Uncharacterized conserved protein [Function unknown]; Region: COG3472 935697002538 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 935697002539 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 935697002540 ligand binding site [chemical binding]; other site 935697002541 NAD binding site [chemical binding]; other site 935697002542 dimerization interface [polypeptide binding]; other site 935697002543 catalytic site [active] 935697002544 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 935697002545 putative L-serine binding site [chemical binding]; other site 935697002546 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 935697002547 tartrate dehydrogenase; Region: TTC; TIGR02089 935697002548 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 935697002549 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 935697002550 ligand binding site [chemical binding]; other site 935697002551 flexible hinge region; other site 935697002552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 935697002553 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935697002554 metal binding triad; other site 935697002555 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 935697002556 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 935697002557 active site 935697002558 catalytic site [active] 935697002559 substrate binding site [chemical binding]; other site 935697002560 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 935697002561 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 935697002562 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 935697002563 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 935697002564 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 935697002565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697002566 HIGH motif; other site 935697002567 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935697002568 active site 935697002569 KMSKS motif; other site 935697002570 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 935697002571 Cutinase; Region: Cutinase; pfam01083 935697002572 biotin synthase; Region: bioB; TIGR00433 935697002573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697002574 FeS/SAM binding site; other site 935697002575 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 935697002576 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935697002577 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935697002578 Zn2+ binding site [ion binding]; other site 935697002579 Mg2+ binding site [ion binding]; other site 935697002580 Transcriptional regulator [Transcription]; Region: IclR; COG1414 935697002581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935697002582 putative DNA binding site [nucleotide binding]; other site 935697002583 putative Zn2+ binding site [ion binding]; other site 935697002584 Bacterial transcriptional regulator; Region: IclR; pfam01614 935697002585 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 935697002586 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 935697002587 substrate binding site [chemical binding]; other site 935697002588 ligand binding site [chemical binding]; other site 935697002589 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 935697002590 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 935697002591 substrate binding site [chemical binding]; other site 935697002592 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 935697002593 active site 935697002594 Ap6A binding site [chemical binding]; other site 935697002595 nudix motif; other site 935697002596 metal binding site [ion binding]; metal-binding site 935697002597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697002598 catalytic core [active] 935697002599 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 935697002600 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 935697002601 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 935697002602 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 935697002603 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 935697002604 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935697002605 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 935697002606 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 935697002607 thiamine monophosphate kinase; Provisional; Region: PRK05731 935697002608 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 935697002609 ATP binding site [chemical binding]; other site 935697002610 dimerization interface [polypeptide binding]; other site 935697002611 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 935697002612 ligand binding site [chemical binding]; other site 935697002613 active site 935697002614 UGI interface [polypeptide binding]; other site 935697002615 catalytic site [active] 935697002616 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 935697002617 DAK2 domain; Region: Dak2; pfam02734 935697002618 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 935697002619 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 935697002620 generic binding surface II; other site 935697002621 ssDNA binding site; other site 935697002622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697002623 ATP binding site [chemical binding]; other site 935697002624 putative Mg++ binding site [ion binding]; other site 935697002625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697002626 nucleotide binding region [chemical binding]; other site 935697002627 ATP-binding site [chemical binding]; other site 935697002628 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 935697002629 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935697002630 carboxyltransferase (CT) interaction site; other site 935697002631 biotinylation site [posttranslational modification]; other site 935697002632 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 935697002633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002634 S-adenosylmethionine binding site [chemical binding]; other site 935697002635 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 935697002636 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 935697002637 active site 935697002638 (T/H)XGH motif; other site 935697002639 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935697002640 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 935697002641 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935697002642 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935697002643 Walker A/P-loop; other site 935697002644 ATP binding site [chemical binding]; other site 935697002645 Q-loop/lid; other site 935697002646 ABC transporter signature motif; other site 935697002647 Walker B; other site 935697002648 D-loop; other site 935697002649 H-loop/switch region; other site 935697002650 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 935697002651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697002652 dimer interface [polypeptide binding]; other site 935697002653 conserved gate region; other site 935697002654 putative PBP binding loops; other site 935697002655 ABC-ATPase subunit interface; other site 935697002656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935697002657 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935697002658 substrate binding pocket [chemical binding]; other site 935697002659 membrane-bound complex binding site; other site 935697002660 hinge residues; other site 935697002661 Domain of unknown function (DUF368); Region: DUF368; pfam04018 935697002662 DNA polymerase I; Provisional; Region: PRK05755 935697002663 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 935697002664 active site 935697002665 metal binding site 1 [ion binding]; metal-binding site 935697002666 putative 5' ssDNA interaction site; other site 935697002667 metal binding site 3; metal-binding site 935697002668 metal binding site 2 [ion binding]; metal-binding site 935697002669 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 935697002670 putative DNA binding site [nucleotide binding]; other site 935697002671 putative metal binding site [ion binding]; other site 935697002672 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 935697002673 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 935697002674 active site 935697002675 DNA binding site [nucleotide binding] 935697002676 catalytic site [active] 935697002677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002678 S-adenosylmethionine binding site [chemical binding]; other site 935697002679 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 935697002680 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 935697002681 RNA binding site [nucleotide binding]; other site 935697002682 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 935697002683 RNA binding site [nucleotide binding]; other site 935697002684 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 935697002685 RNA binding site [nucleotide binding]; other site 935697002686 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 935697002687 RNA binding site [nucleotide binding]; other site 935697002688 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 935697002689 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 935697002690 active site turn [active] 935697002691 phosphorylation site [posttranslational modification] 935697002692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 935697002693 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 935697002694 HPr interaction site; other site 935697002695 glycerol kinase (GK) interaction site [polypeptide binding]; other site 935697002696 active site 935697002697 phosphorylation site [posttranslational modification] 935697002698 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 935697002699 ATP-binding [chemical binding]; other site 935697002700 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 935697002701 CoA-binding site [chemical binding]; other site 935697002702 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 935697002703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697002704 FeS/SAM binding site; other site 935697002705 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 935697002706 excinuclease ABC subunit B; Provisional; Region: PRK05298 935697002707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697002708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697002709 nucleotide binding region [chemical binding]; other site 935697002710 ATP-binding site [chemical binding]; other site 935697002711 Ultra-violet resistance protein B; Region: UvrB; pfam12344 935697002712 UvrB/uvrC motif; Region: UVR; pfam02151 935697002713 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935697002714 Ligand Binding Site [chemical binding]; other site 935697002715 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 935697002716 Part of AAA domain; Region: AAA_19; pfam13245 935697002717 Family description; Region: UvrD_C_2; pfam13538 935697002718 Predicted membrane protein [Function unknown]; Region: COG2259 935697002719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 935697002720 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 935697002721 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935697002722 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 935697002723 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 935697002724 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 935697002725 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 935697002726 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 935697002727 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 935697002728 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 935697002729 23S rRNA binding site [nucleotide binding]; other site 935697002730 L21 binding site [polypeptide binding]; other site 935697002731 L13 binding site [polypeptide binding]; other site 935697002732 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935697002733 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 935697002734 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935697002735 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 935697002736 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 935697002737 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 935697002738 dimer interface [polypeptide binding]; other site 935697002739 motif 1; other site 935697002740 active site 935697002741 motif 2; other site 935697002742 motif 3; other site 935697002743 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 935697002744 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 935697002745 putative tRNA-binding site [nucleotide binding]; other site 935697002746 B3/4 domain; Region: B3_4; pfam03483 935697002747 tRNA synthetase B5 domain; Region: B5; smart00874 935697002748 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 935697002749 dimer interface [polypeptide binding]; other site 935697002750 motif 1; other site 935697002751 motif 3; other site 935697002752 motif 2; other site 935697002753 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 935697002754 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 935697002755 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935697002756 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 935697002757 feedback inhibition sensing region; other site 935697002758 homohexameric interface [polypeptide binding]; other site 935697002759 nucleotide binding site [chemical binding]; other site 935697002760 N-acetyl-L-glutamate binding site [chemical binding]; other site 935697002761 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 935697002762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935697002763 inhibitor-cofactor binding pocket; inhibition site 935697002764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697002765 catalytic residue [active] 935697002766 ornithine carbamoyltransferase; Provisional; Region: PRK00779 935697002767 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935697002768 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935697002769 arginine repressor; Provisional; Region: PRK03341 935697002770 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 935697002771 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 935697002772 argininosuccinate synthase; Provisional; Region: PRK13820 935697002773 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 935697002774 ANP binding site [chemical binding]; other site 935697002775 Substrate Binding Site II [chemical binding]; other site 935697002776 Substrate Binding Site I [chemical binding]; other site 935697002777 argininosuccinate lyase; Provisional; Region: PRK00855 935697002778 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 935697002779 active sites [active] 935697002780 tetramer interface [polypeptide binding]; other site 935697002781 Uncharacterized conserved protein [Function unknown]; Region: COG2835 935697002782 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 935697002783 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 935697002784 active site 935697002785 HIGH motif; other site 935697002786 dimer interface [polypeptide binding]; other site 935697002787 KMSKS motif; other site 935697002788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697002789 RNA binding surface [nucleotide binding]; other site 935697002790 transcription termination factor Rho; Provisional; Region: PRK12678 935697002791 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 935697002792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697002793 active site 935697002794 motif I; other site 935697002795 motif II; other site 935697002796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697002797 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 935697002798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697002799 RNA binding surface [nucleotide binding]; other site 935697002800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002801 S-adenosylmethionine binding site [chemical binding]; other site 935697002802 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 935697002803 ATP-NAD kinase; Region: NAD_kinase; pfam01513 935697002804 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 935697002805 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935697002806 Walker A/P-loop; other site 935697002807 ATP binding site [chemical binding]; other site 935697002808 Q-loop/lid; other site 935697002809 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935697002810 ABC transporter signature motif; other site 935697002811 Walker B; other site 935697002812 D-loop; other site 935697002813 H-loop/switch region; other site 935697002814 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 935697002815 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 935697002816 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 935697002817 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 935697002818 dimer interface [polypeptide binding]; other site 935697002819 ADP-ribose binding site [chemical binding]; other site 935697002820 active site 935697002821 nudix motif; other site 935697002822 metal binding site [ion binding]; metal-binding site 935697002823 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 935697002824 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935697002825 active site 935697002826 Int/Topo IB signature motif; other site 935697002827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 935697002828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935697002829 P-loop; other site 935697002830 Magnesium ion binding site [ion binding]; other site 935697002831 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 935697002832 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 935697002833 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 935697002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935697002836 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 935697002837 inhibitor-cofactor binding pocket; inhibition site 935697002838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697002839 catalytic residue [active] 935697002840 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 935697002841 AAA domain; Region: AAA_26; pfam13500 935697002842 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 935697002843 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935697002844 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697002845 RNA binding surface [nucleotide binding]; other site 935697002846 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 935697002847 active site 935697002848 cytidylate kinase; Provisional; Region: cmk; PRK00023 935697002849 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 935697002850 CMP-binding site; other site 935697002851 The sites determining sugar specificity; other site 935697002852 GTP-binding protein Der; Reviewed; Region: PRK03003 935697002853 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 935697002854 G1 box; other site 935697002855 GTP/Mg2+ binding site [chemical binding]; other site 935697002856 Switch I region; other site 935697002857 G2 box; other site 935697002858 Switch II region; other site 935697002859 G3 box; other site 935697002860 G4 box; other site 935697002861 G5 box; other site 935697002862 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 935697002863 G1 box; other site 935697002864 GTP/Mg2+ binding site [chemical binding]; other site 935697002865 Switch I region; other site 935697002866 G2 box; other site 935697002867 G3 box; other site 935697002868 Switch II region; other site 935697002869 G4 box; other site 935697002870 G5 box; other site 935697002871 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 935697002872 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 935697002873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002874 S-adenosylmethionine binding site [chemical binding]; other site 935697002875 Putative esterase; Region: Esterase; pfam00756 935697002876 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 935697002877 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 935697002878 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697002879 intersubunit interface [polypeptide binding]; other site 935697002880 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697002881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697002882 dimer interface [polypeptide binding]; other site 935697002883 ABC-ATPase subunit interface; other site 935697002884 putative PBP binding regions; other site 935697002885 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697002886 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697002887 ABC-ATPase subunit interface; other site 935697002888 dimer interface [polypeptide binding]; other site 935697002889 putative PBP binding regions; other site 935697002890 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 935697002891 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697002892 Walker A/P-loop; other site 935697002893 ATP binding site [chemical binding]; other site 935697002894 Q-loop/lid; other site 935697002895 ABC transporter signature motif; other site 935697002896 Walker B; other site 935697002897 D-loop; other site 935697002898 H-loop/switch region; other site 935697002899 IucA / IucC family; Region: IucA_IucC; pfam04183 935697002900 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 935697002901 IucA / IucC family; Region: IucA_IucC; pfam04183 935697002902 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 935697002903 H+ Antiporter protein; Region: 2A0121; TIGR00900 935697002904 hypothetical protein; Provisional; Region: PRK01842 935697002905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 935697002906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 935697002907 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 935697002908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 935697002909 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 935697002910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697002911 nucleotide binding region [chemical binding]; other site 935697002912 ATP-binding site [chemical binding]; other site 935697002913 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 935697002914 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 935697002915 phosphopeptide binding site; other site 935697002916 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 935697002917 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 935697002918 DNA binding residues [nucleotide binding] 935697002919 Bifunctional nuclease; Region: DNase-RNase; pfam02577 935697002920 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 935697002921 DNA binding residues [nucleotide binding] 935697002922 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 935697002923 putative dimer interface [polypeptide binding]; other site 935697002924 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 935697002925 metal ion-dependent adhesion site (MIDAS); other site 935697002926 Domain of unknown function DUF21; Region: DUF21; pfam01595 935697002927 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 935697002928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935697002929 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 935697002930 Domain of unknown function DUF21; Region: DUF21; pfam01595 935697002931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935697002932 Transporter associated domain; Region: CorC_HlyC; smart01091 935697002933 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 935697002934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 935697002935 ATP binding site [chemical binding]; other site 935697002936 putative Mg++ binding site [ion binding]; other site 935697002937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697002938 nucleotide binding region [chemical binding]; other site 935697002939 ATP-binding site [chemical binding]; other site 935697002940 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935697002941 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 935697002942 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 935697002943 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 935697002944 CoenzymeA binding site [chemical binding]; other site 935697002945 subunit interaction site [polypeptide binding]; other site 935697002946 PHB binding site; other site 935697002947 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 935697002948 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 935697002949 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 935697002950 oligomer interface [polypeptide binding]; other site 935697002951 metal binding site [ion binding]; metal-binding site 935697002952 metal binding site [ion binding]; metal-binding site 935697002953 putative Cl binding site [ion binding]; other site 935697002954 basic sphincter; other site 935697002955 hydrophobic gate; other site 935697002956 periplasmic entrance; other site 935697002957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697002958 S-adenosylmethionine binding site [chemical binding]; other site 935697002959 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 935697002960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935697002961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935697002962 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 935697002963 metabolite-proton symporter; Region: 2A0106; TIGR00883 935697002964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697002965 putative substrate translocation pore; other site 935697002966 YceI-like domain; Region: YceI; pfam04264 935697002967 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 935697002968 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 935697002969 Ligand binding site; other site 935697002970 Putative Catalytic site; other site 935697002971 DXD motif; other site 935697002972 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 935697002973 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 935697002974 putative active site [active] 935697002975 catalytic triad [active] 935697002976 putative dimer interface [polypeptide binding]; other site 935697002977 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 935697002978 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 935697002979 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 935697002980 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 935697002981 precorrin-3B synthase; Region: CobG; TIGR02435 935697002982 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935697002983 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935697002984 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 935697002985 Precorrin-8X methylmutase; Region: CbiC; pfam02570 935697002986 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 935697002987 active site 935697002988 SAM binding site [chemical binding]; other site 935697002989 homodimer interface [polypeptide binding]; other site 935697002990 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 935697002991 active site 935697002992 SAM binding site [chemical binding]; other site 935697002993 homodimer interface [polypeptide binding]; other site 935697002994 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 935697002995 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 935697002996 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 935697002997 active site 935697002998 SAM binding site [chemical binding]; other site 935697002999 homodimer interface [polypeptide binding]; other site 935697003000 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 935697003001 active site 935697003002 putative homodimer interface [polypeptide binding]; other site 935697003003 SAM binding site [chemical binding]; other site 935697003004 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 935697003005 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 935697003006 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 935697003007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697003008 NAD(P) binding site [chemical binding]; other site 935697003009 active site 935697003010 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 935697003011 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935697003012 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 935697003013 active site 935697003014 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 935697003015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697003016 ATP binding site [chemical binding]; other site 935697003017 putative Mg++ binding site [ion binding]; other site 935697003018 helicase superfamily c-terminal domain; Region: HELICc; smart00490 935697003019 nucleotide binding region [chemical binding]; other site 935697003020 ATP-binding site [chemical binding]; other site 935697003021 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 935697003022 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 935697003023 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 935697003024 Predicted transcriptional regulator [Transcription]; Region: COG2378 935697003025 WYL domain; Region: WYL; pfam13280 935697003026 Predicted transcriptional regulator [Transcription]; Region: COG2378 935697003027 WYL domain; Region: WYL; pfam13280 935697003028 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 935697003029 Pup-like protein; Region: Pup; pfam05639 935697003030 Pup-ligase protein; Region: Pup_ligase; cl15463 935697003031 proteasome ATPase; Region: pup_AAA; TIGR03689 935697003032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697003033 Walker A motif; other site 935697003034 ATP binding site [chemical binding]; other site 935697003035 Walker B motif; other site 935697003036 arginine finger; other site 935697003037 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 935697003038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935697003039 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 935697003040 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 935697003041 active site 935697003042 metal binding site [ion binding]; metal-binding site 935697003043 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 935697003044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 935697003045 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 935697003046 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 935697003047 Potassium binding sites [ion binding]; other site 935697003048 Cesium cation binding sites [ion binding]; other site 935697003049 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 935697003050 Aspartase; Region: Aspartase; cd01357 935697003051 active sites [active] 935697003052 tetramer interface [polypeptide binding]; other site 935697003053 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 935697003054 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 935697003055 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 935697003056 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 935697003057 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 935697003058 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 935697003059 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 935697003060 homodimer interface [polypeptide binding]; other site 935697003061 putative metal binding site [ion binding]; other site 935697003062 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 935697003063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697003064 motif II; other site 935697003065 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 935697003066 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 935697003067 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 935697003068 substrate binding pocket [chemical binding]; other site 935697003069 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 935697003070 B12 binding site [chemical binding]; other site 935697003071 cobalt ligand [ion binding]; other site 935697003072 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 935697003073 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 935697003074 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697003075 active site 935697003076 HIGH motif; other site 935697003077 nucleotide binding site [chemical binding]; other site 935697003078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697003079 active site 935697003080 KMSKS motif; other site 935697003081 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 935697003082 tRNA binding surface [nucleotide binding]; other site 935697003083 anticodon binding site; other site 935697003084 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 935697003085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 935697003086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 935697003087 active site 935697003088 catalytic tetrad [active] 935697003089 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 935697003090 substrate binding site [chemical binding]; other site 935697003091 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 935697003092 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 935697003093 dimerization domain swap beta strand [polypeptide binding]; other site 935697003094 regulatory protein interface [polypeptide binding]; other site 935697003095 active site 935697003096 regulatory phosphorylation site [posttranslational modification]; other site 935697003097 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 935697003098 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 935697003099 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 935697003100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697003101 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 935697003102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697003103 NAD(P) binding site [chemical binding]; other site 935697003104 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 935697003105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697003106 NAD(P) binding site [chemical binding]; other site 935697003107 active site 935697003108 membrane ATPase/protein kinase; Provisional; Region: PRK09435 935697003109 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 935697003110 Walker A; other site 935697003111 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 935697003112 G4 box; other site 935697003113 G5 box; other site 935697003114 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 935697003115 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 935697003116 active site 935697003117 substrate binding site [chemical binding]; other site 935697003118 coenzyme B12 binding site [chemical binding]; other site 935697003119 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 935697003120 B12 binding site [chemical binding]; other site 935697003121 cobalt ligand [ion binding]; other site 935697003122 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 935697003123 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 935697003124 heterodimer interface [polypeptide binding]; other site 935697003125 substrate interaction site [chemical binding]; other site 935697003126 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 935697003127 Uncharacterized conserved protein [Function unknown]; Region: COG0398 935697003128 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 935697003129 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 935697003130 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 935697003131 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 935697003132 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 935697003133 ferrochelatase; Reviewed; Region: hemH; PRK00035 935697003134 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 935697003135 C-terminal domain interface [polypeptide binding]; other site 935697003136 active site 935697003137 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 935697003138 active site 935697003139 N-terminal domain interface [polypeptide binding]; other site 935697003140 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935697003141 NlpC/P60 family; Region: NLPC_P60; pfam00877 935697003142 pyruvate carboxylase subunit A; Validated; Region: PRK07178 935697003143 aconitate hydratase; Validated; Region: PRK09277 935697003144 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 935697003145 substrate binding site [chemical binding]; other site 935697003146 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 935697003147 ligand binding site [chemical binding]; other site 935697003148 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 935697003149 substrate binding site [chemical binding]; other site 935697003150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697003151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697003152 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 935697003153 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 935697003154 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 935697003155 catalytic triad [active] 935697003156 conserved cys residue [active] 935697003157 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 935697003158 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 935697003159 AAA ATPase domain; Region: AAA_16; pfam13191 935697003160 AAA domain; Region: AAA_22; pfam13401 935697003161 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 935697003162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697003163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697003164 Walker A/P-loop; other site 935697003165 ATP binding site [chemical binding]; other site 935697003166 Q-loop/lid; other site 935697003167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697003168 ABC transporter signature motif; other site 935697003169 Walker B; other site 935697003170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697003171 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 935697003172 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 935697003173 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 935697003174 trimerization site [polypeptide binding]; other site 935697003175 active site 935697003176 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 935697003177 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 935697003178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935697003179 catalytic residue [active] 935697003180 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 935697003181 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 935697003182 Walker A/P-loop; other site 935697003183 ATP binding site [chemical binding]; other site 935697003184 Q-loop/lid; other site 935697003185 ABC transporter signature motif; other site 935697003186 Walker B; other site 935697003187 D-loop; other site 935697003188 H-loop/switch region; other site 935697003189 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 935697003190 FeS assembly protein SufD; Region: sufD; TIGR01981 935697003191 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 935697003192 FeS assembly protein SufB; Region: sufB; TIGR01980 935697003193 Predicted transcriptional regulator [Transcription]; Region: COG2345 935697003194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935697003195 putative DNA binding site [nucleotide binding]; other site 935697003196 putative Zn2+ binding site [ion binding]; other site 935697003197 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 935697003198 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 935697003199 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 935697003200 Walker A/P-loop; other site 935697003201 ATP binding site [chemical binding]; other site 935697003202 Q-loop/lid; other site 935697003203 ABC transporter signature motif; other site 935697003204 Walker B; other site 935697003205 D-loop; other site 935697003206 H-loop/switch region; other site 935697003207 ABC-2 type transporter; Region: ABC2_membrane; cl17235 935697003208 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 935697003209 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 935697003210 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 935697003211 UbiA prenyltransferase family; Region: UbiA; pfam01040 935697003212 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 935697003213 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 935697003214 TPP-binding site [chemical binding]; other site 935697003215 dimer interface [polypeptide binding]; other site 935697003216 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935697003217 PYR/PP interface [polypeptide binding]; other site 935697003218 dimer interface [polypeptide binding]; other site 935697003219 TPP binding site [chemical binding]; other site 935697003220 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935697003221 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 935697003222 putative active site [active] 935697003223 transaldolase; Provisional; Region: PRK03903 935697003224 catalytic residue [active] 935697003225 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 935697003226 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 935697003227 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 935697003228 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 935697003229 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 935697003230 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 935697003231 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 935697003232 putative active site [active] 935697003233 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 935697003234 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 935697003235 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 935697003236 triosephosphate isomerase; Provisional; Region: PRK14567 935697003237 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 935697003238 substrate binding site [chemical binding]; other site 935697003239 dimer interface [polypeptide binding]; other site 935697003240 catalytic triad [active] 935697003241 Phosphoglycerate kinase; Region: PGK; pfam00162 935697003242 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 935697003243 substrate binding site [chemical binding]; other site 935697003244 hinge regions; other site 935697003245 ADP binding site [chemical binding]; other site 935697003246 catalytic site [active] 935697003247 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 935697003248 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 935697003249 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935697003250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 935697003251 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 935697003252 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 935697003253 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 935697003254 phosphate binding site [ion binding]; other site 935697003255 putative substrate binding pocket [chemical binding]; other site 935697003256 dimer interface [polypeptide binding]; other site 935697003257 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 935697003258 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 935697003259 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 935697003260 GIY-YIG motif/motif A; other site 935697003261 active site 935697003262 catalytic site [active] 935697003263 putative DNA binding site [nucleotide binding]; other site 935697003264 metal binding site [ion binding]; metal-binding site 935697003265 UvrB/uvrC motif; Region: UVR; pfam02151 935697003266 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 935697003267 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 935697003268 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 935697003269 homopentamer interface [polypeptide binding]; other site 935697003270 active site 935697003271 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 935697003272 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 935697003273 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 935697003274 dimerization interface [polypeptide binding]; other site 935697003275 active site 935697003276 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 935697003277 Lumazine binding domain; Region: Lum_binding; pfam00677 935697003278 Lumazine binding domain; Region: Lum_binding; pfam00677 935697003279 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 935697003280 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 935697003281 catalytic motif [active] 935697003282 Zn binding site [ion binding]; other site 935697003283 RibD C-terminal domain; Region: RibD_C; pfam01872 935697003284 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 935697003285 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 935697003286 substrate binding site [chemical binding]; other site 935697003287 hexamer interface [polypeptide binding]; other site 935697003288 metal binding site [ion binding]; metal-binding site 935697003289 16S rRNA methyltransferase B; Provisional; Region: PRK14902 935697003290 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 935697003291 putative RNA binding site [nucleotide binding]; other site 935697003292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697003293 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 935697003294 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 935697003295 putative active site [active] 935697003296 substrate binding site [chemical binding]; other site 935697003297 putative cosubstrate binding site; other site 935697003298 catalytic site [active] 935697003299 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 935697003300 substrate binding site [chemical binding]; other site 935697003301 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 935697003302 active site 935697003303 catalytic residues [active] 935697003304 metal binding site [ion binding]; metal-binding site 935697003305 primosome assembly protein PriA; Provisional; Region: PRK14873 935697003306 S-adenosylmethionine synthetase; Validated; Region: PRK05250 935697003307 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 935697003308 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 935697003309 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 935697003310 Flavoprotein; Region: Flavoprotein; pfam02441 935697003311 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 935697003312 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 935697003313 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 935697003314 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 935697003315 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 935697003316 catalytic site [active] 935697003317 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 935697003318 active site 935697003319 dimer interface [polypeptide binding]; other site 935697003320 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 935697003321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935697003322 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935697003323 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 935697003324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935697003325 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935697003326 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 935697003327 substrate binding site [chemical binding]; other site 935697003328 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 935697003329 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 935697003330 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 935697003331 catalytic site [active] 935697003332 subunit interface [polypeptide binding]; other site 935697003333 dihydroorotase; Validated; Region: pyrC; PRK09357 935697003334 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 935697003335 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 935697003336 active site 935697003337 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 935697003338 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935697003339 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935697003340 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 935697003341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697003342 active site 935697003343 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 935697003344 putative hydrophobic ligand binding site [chemical binding]; other site 935697003345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697003346 TIGR01777 family protein; Region: yfcH 935697003347 NAD(P) binding site [chemical binding]; other site 935697003348 active site 935697003349 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 935697003350 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 935697003351 elongation factor P; Validated; Region: PRK00529 935697003352 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 935697003353 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 935697003354 RNA binding site [nucleotide binding]; other site 935697003355 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 935697003356 RNA binding site [nucleotide binding]; other site 935697003357 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 935697003358 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935697003359 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 935697003360 active site 935697003361 Dehydroquinase class II; Region: DHquinase_II; pfam01220 935697003362 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 935697003363 trimer interface [polypeptide binding]; other site 935697003364 active site 935697003365 dimer interface [polypeptide binding]; other site 935697003366 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 935697003367 active site 935697003368 dimer interface [polypeptide binding]; other site 935697003369 metal binding site [ion binding]; metal-binding site 935697003370 shikimate kinase; Reviewed; Region: aroK; PRK00131 935697003371 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 935697003372 ADP binding site [chemical binding]; other site 935697003373 magnesium binding site [ion binding]; other site 935697003374 putative shikimate binding site; other site 935697003375 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 935697003376 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 935697003377 Tetramer interface [polypeptide binding]; other site 935697003378 active site 935697003379 FMN-binding site [chemical binding]; other site 935697003380 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 935697003381 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 935697003382 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 935697003383 shikimate binding site; other site 935697003384 NAD(P) binding site [chemical binding]; other site 935697003385 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 935697003386 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 935697003387 dimerization interface [polypeptide binding]; other site 935697003388 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 935697003389 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 935697003390 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 935697003391 motif 1; other site 935697003392 active site 935697003393 motif 2; other site 935697003394 motif 3; other site 935697003395 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 935697003396 DHHA1 domain; Region: DHHA1; pfam02272 935697003397 recombination factor protein RarA; Reviewed; Region: PRK13342 935697003398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697003399 Walker A motif; other site 935697003400 ATP binding site [chemical binding]; other site 935697003401 Walker B motif; other site 935697003402 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 935697003403 Phosphotransferase enzyme family; Region: APH; pfam01636 935697003404 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 935697003405 substrate binding site [chemical binding]; other site 935697003406 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 935697003407 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 935697003408 dimer interface [polypeptide binding]; other site 935697003409 anticodon binding site; other site 935697003410 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935697003411 homodimer interface [polypeptide binding]; other site 935697003412 motif 1; other site 935697003413 active site 935697003414 motif 2; other site 935697003415 GAD domain; Region: GAD; pfam02938 935697003416 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935697003417 active site 935697003418 motif 3; other site 935697003419 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935697003420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697003421 ATP binding site [chemical binding]; other site 935697003422 putative Mg++ binding site [ion binding]; other site 935697003423 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 935697003424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697003425 nucleotide binding region [chemical binding]; other site 935697003426 ATP-binding site [chemical binding]; other site 935697003427 Predicted membrane protein [Function unknown]; Region: COG1511 935697003428 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 935697003429 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 935697003430 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 935697003431 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 935697003432 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 935697003433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697003434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697003435 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 935697003436 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 935697003437 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 935697003438 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 935697003439 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 935697003440 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 935697003441 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 935697003442 putative active site [active] 935697003443 putative catalytic site [active] 935697003444 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 935697003445 CoA-transferase family III; Region: CoA_transf_3; pfam02515 935697003446 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 935697003447 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 935697003448 dimer interface [polypeptide binding]; other site 935697003449 motif 1; other site 935697003450 active site 935697003451 motif 2; other site 935697003452 motif 3; other site 935697003453 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 935697003454 anticodon binding site; other site 935697003455 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 935697003456 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 935697003457 dimer interface [polypeptide binding]; other site 935697003458 catalytic triad [active] 935697003459 peroxidatic and resolving cysteines [active] 935697003460 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 935697003461 active site 935697003462 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935697003463 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935697003464 Zn2+ binding site [ion binding]; other site 935697003465 Mg2+ binding site [ion binding]; other site 935697003466 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935697003467 synthetase active site [active] 935697003468 NTP binding site [chemical binding]; other site 935697003469 metal binding site [ion binding]; metal-binding site 935697003470 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935697003471 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 935697003472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697003473 active site 935697003474 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 935697003475 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 935697003476 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 935697003477 Protein export membrane protein; Region: SecD_SecF; pfam02355 935697003478 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 935697003479 Protein export membrane protein; Region: SecD_SecF; cl14618 935697003480 Preprotein translocase subunit; Region: YajC; pfam02699 935697003481 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 935697003482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697003483 Walker A motif; other site 935697003484 ATP binding site [chemical binding]; other site 935697003485 Walker B motif; other site 935697003486 arginine finger; other site 935697003487 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 935697003488 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 935697003489 RuvA N terminal domain; Region: RuvA_N; pfam01330 935697003490 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 935697003491 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 935697003492 active site 935697003493 putative DNA-binding cleft [nucleotide binding]; other site 935697003494 dimer interface [polypeptide binding]; other site 935697003495 hypothetical protein; Validated; Region: PRK00110 935697003496 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 935697003497 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 935697003498 active site 935697003499 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 935697003500 catalytic triad [active] 935697003501 dimer interface [polypeptide binding]; other site 935697003502 Protein of unknown function (DUF998); Region: DUF998; pfam06197 935697003503 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 935697003504 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 935697003505 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 935697003506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935697003507 catalytic residue [active] 935697003508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935697003509 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935697003510 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935697003511 putative acyl-acceptor binding pocket; other site 935697003512 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 935697003513 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 935697003514 nucleotide binding site/active site [active] 935697003515 HIT family signature motif; other site 935697003516 catalytic residue [active] 935697003517 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 935697003518 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 935697003519 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 935697003520 active site 935697003521 dimer interface [polypeptide binding]; other site 935697003522 motif 1; other site 935697003523 motif 2; other site 935697003524 motif 3; other site 935697003525 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 935697003526 anticodon binding site; other site 935697003527 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 935697003528 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 935697003529 Protein of unknown function (DUF461); Region: DUF461; pfam04314 935697003530 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 935697003531 hypothetical protein; Provisional; Region: PRK14059 935697003532 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 935697003533 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 935697003534 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 935697003535 SelR domain; Region: SelR; pfam01641 935697003536 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 935697003537 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 935697003538 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 935697003539 catalytic site [active] 935697003540 putative active site [active] 935697003541 putative substrate binding site [chemical binding]; other site 935697003542 HRDC domain; Region: HRDC; pfam00570 935697003543 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 935697003544 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 935697003545 TPP-binding site; other site 935697003546 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935697003547 PYR/PP interface [polypeptide binding]; other site 935697003548 dimer interface [polypeptide binding]; other site 935697003549 TPP binding site [chemical binding]; other site 935697003550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935697003551 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 935697003552 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 935697003553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697003554 S-adenosylmethionine binding site [chemical binding]; other site 935697003555 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 935697003556 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 935697003557 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935697003558 trimer interface [polypeptide binding]; other site 935697003559 active site 935697003560 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 935697003561 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 935697003562 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935697003563 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 935697003564 active site 935697003565 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 935697003566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 935697003567 nucleotide binding site [chemical binding]; other site 935697003568 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 935697003569 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935697003570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697003571 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 935697003572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697003573 DNA binding residues [nucleotide binding] 935697003574 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 935697003575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697003576 ATP binding site [chemical binding]; other site 935697003577 putative Mg++ binding site [ion binding]; other site 935697003578 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 935697003579 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 935697003580 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 935697003581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697003582 S-adenosylmethionine binding site [chemical binding]; other site 935697003583 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 935697003584 putative active site [active] 935697003585 dimerization interface [polypeptide binding]; other site 935697003586 putative tRNAtyr binding site [nucleotide binding]; other site 935697003587 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 935697003588 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935697003589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697003590 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 935697003591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697003592 DNA binding residues [nucleotide binding] 935697003593 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 935697003594 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 935697003595 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 935697003596 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 935697003597 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 935697003598 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 935697003599 NAD binding site [chemical binding]; other site 935697003600 homodimer interface [polypeptide binding]; other site 935697003601 active site 935697003602 substrate binding site [chemical binding]; other site 935697003603 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 935697003604 PAC2 family; Region: PAC2; pfam09754 935697003605 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 935697003606 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 935697003607 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935697003608 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 935697003609 dimer interface [polypeptide binding]; other site 935697003610 decamer (pentamer of dimers) interface [polypeptide binding]; other site 935697003611 catalytic triad [active] 935697003612 peroxidatic and resolving cysteines [active] 935697003613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935697003614 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 935697003615 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 935697003616 dimerization interface [polypeptide binding]; other site 935697003617 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 935697003618 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 935697003619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697003620 ATP binding site [chemical binding]; other site 935697003621 putative Mg++ binding site [ion binding]; other site 935697003622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935697003623 nucleotide binding region [chemical binding]; other site 935697003624 ATP-binding site [chemical binding]; other site 935697003625 Helicase associated domain (HA2); Region: HA2; pfam04408 935697003626 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 935697003627 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935697003628 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 935697003629 ATP cone domain; Region: ATP-cone; pfam03477 935697003630 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 935697003631 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 935697003632 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 935697003633 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 935697003634 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 935697003635 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935697003636 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935697003637 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 935697003638 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 935697003639 putative substrate binding site [chemical binding]; other site 935697003640 putative ATP binding site [chemical binding]; other site 935697003641 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 935697003642 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 935697003643 active site 935697003644 phosphorylation site [posttranslational modification] 935697003645 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 935697003646 active site 935697003647 P-loop; other site 935697003648 phosphorylation site [posttranslational modification] 935697003649 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 935697003650 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 935697003651 dimerization domain swap beta strand [polypeptide binding]; other site 935697003652 regulatory protein interface [polypeptide binding]; other site 935697003653 active site 935697003654 regulatory phosphorylation site [posttranslational modification]; other site 935697003655 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 935697003656 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 935697003657 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 935697003658 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 935697003659 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 935697003660 GTPases [General function prediction only]; Region: HflX; COG2262 935697003661 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 935697003662 HflX GTPase family; Region: HflX; cd01878 935697003663 G1 box; other site 935697003664 GTP/Mg2+ binding site [chemical binding]; other site 935697003665 Switch I region; other site 935697003666 G2 box; other site 935697003667 G3 box; other site 935697003668 Switch II region; other site 935697003669 G4 box; other site 935697003670 G5 box; other site 935697003671 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 935697003672 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935697003673 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935697003674 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 935697003675 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 935697003676 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 935697003677 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 935697003678 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 935697003679 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 935697003680 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 935697003681 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 935697003682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697003683 FeS/SAM binding site; other site 935697003684 recombination regulator RecX; Reviewed; Region: recX; PRK00117 935697003685 recombinase A; Provisional; Region: recA; PRK09354 935697003686 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 935697003687 hexamer interface [polypeptide binding]; other site 935697003688 Walker A motif; other site 935697003689 ATP binding site [chemical binding]; other site 935697003690 Walker B motif; other site 935697003691 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 935697003692 BioY family; Region: BioY; pfam02632 935697003693 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 935697003694 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 935697003695 Walker A/P-loop; other site 935697003696 ATP binding site [chemical binding]; other site 935697003697 Q-loop/lid; other site 935697003698 ABC transporter signature motif; other site 935697003699 Walker B; other site 935697003700 D-loop; other site 935697003701 H-loop/switch region; other site 935697003702 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 935697003703 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 935697003704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935697003705 sequence-specific DNA binding site [nucleotide binding]; other site 935697003706 salt bridge; other site 935697003707 Competence-damaged protein; Region: CinA; pfam02464 935697003708 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 935697003709 YCII-related domain; Region: YCII; cl00999 935697003710 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 935697003711 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 935697003712 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935697003713 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935697003714 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 935697003715 TIGR03085 family protein; Region: TIGR03085 935697003716 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 935697003717 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 935697003718 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 935697003719 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 935697003720 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 935697003721 dimer interface [polypeptide binding]; other site 935697003722 active site 935697003723 catalytic residue [active] 935697003724 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 935697003725 dihydrodipicolinate reductase; Provisional; Region: PRK00048 935697003726 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 935697003727 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 935697003728 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 935697003729 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 935697003730 oligomer interface [polypeptide binding]; other site 935697003731 RNA binding site [nucleotide binding]; other site 935697003732 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 935697003733 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 935697003734 RNase E interface [polypeptide binding]; other site 935697003735 trimer interface [polypeptide binding]; other site 935697003736 active site 935697003737 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 935697003738 putative nucleic acid binding region [nucleotide binding]; other site 935697003739 G-X-X-G motif; other site 935697003740 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 935697003741 RNA binding site [nucleotide binding]; other site 935697003742 domain interface; other site 935697003743 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 935697003744 16S/18S rRNA binding site [nucleotide binding]; other site 935697003745 S13e-L30e interaction site [polypeptide binding]; other site 935697003746 25S rRNA binding site [nucleotide binding]; other site 935697003747 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 935697003748 active site 935697003749 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 935697003750 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 935697003751 active site 935697003752 Riboflavin kinase; Region: Flavokinase; smart00904 935697003753 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 935697003754 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 935697003755 RNA binding site [nucleotide binding]; other site 935697003756 active site 935697003757 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 935697003758 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 935697003759 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 935697003760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 935697003761 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 935697003762 active site 935697003763 metal binding site [ion binding]; metal-binding site 935697003764 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 935697003765 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 935697003766 DHH family; Region: DHH; pfam01368 935697003767 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 935697003768 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 935697003769 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935697003770 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935697003771 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 935697003772 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 935697003773 G1 box; other site 935697003774 putative GEF interaction site [polypeptide binding]; other site 935697003775 GTP/Mg2+ binding site [chemical binding]; other site 935697003776 Switch I region; other site 935697003777 G2 box; other site 935697003778 G3 box; other site 935697003779 Switch II region; other site 935697003780 G4 box; other site 935697003781 G5 box; other site 935697003782 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 935697003783 Translation-initiation factor 2; Region: IF-2; pfam11987 935697003784 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 935697003785 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 935697003786 putative RNA binding cleft [nucleotide binding]; other site 935697003787 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 935697003788 NusA N-terminal domain; Region: NusA_N; pfam08529 935697003789 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 935697003790 RNA binding site [nucleotide binding]; other site 935697003791 homodimer interface [polypeptide binding]; other site 935697003792 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 935697003793 G-X-X-G motif; other site 935697003794 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 935697003795 G-X-X-G motif; other site 935697003796 ribosome maturation protein RimP; Reviewed; Region: PRK00092 935697003797 Sm and related proteins; Region: Sm_like; cl00259 935697003798 heptamer interface [polypeptide binding]; other site 935697003799 Sm1 motif; other site 935697003800 hexamer interface [polypeptide binding]; other site 935697003801 RNA binding site [nucleotide binding]; other site 935697003802 Sm2 motif; other site 935697003803 prolyl-tRNA synthetase; Provisional; Region: PRK09194 935697003804 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 935697003805 dimer interface [polypeptide binding]; other site 935697003806 motif 1; other site 935697003807 active site 935697003808 motif 2; other site 935697003809 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 935697003810 putative deacylase active site [active] 935697003811 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935697003812 active site 935697003813 motif 3; other site 935697003814 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 935697003815 anticodon binding site; other site 935697003816 hypothetical protein; Validated; Region: PRK02101 935697003817 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 935697003818 active site 935697003819 SAM binding site [chemical binding]; other site 935697003820 homodimer interface [polypeptide binding]; other site 935697003821 hypothetical protein; Validated; Region: PRK00029 935697003822 Uncharacterized conserved protein [Function unknown]; Region: COG0397 935697003823 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 935697003824 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 935697003825 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 935697003826 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 935697003827 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 935697003828 DNA binding site [nucleotide binding] 935697003829 active site 935697003830 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 935697003831 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 935697003832 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 935697003833 catalytic triad [active] 935697003834 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 935697003835 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 935697003836 homodimer interface [polypeptide binding]; other site 935697003837 Walker A motif; other site 935697003838 ATP binding site [chemical binding]; other site 935697003839 hydroxycobalamin binding site [chemical binding]; other site 935697003840 Walker B motif; other site 935697003841 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 935697003842 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 935697003843 metal ion-dependent adhesion site (MIDAS); other site 935697003844 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 935697003845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697003846 Walker A motif; other site 935697003847 ATP binding site [chemical binding]; other site 935697003848 Walker B motif; other site 935697003849 arginine finger; other site 935697003850 malate:quinone oxidoreductase; Validated; Region: PRK05257 935697003851 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 935697003852 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 935697003853 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 935697003854 mycothione reductase; Reviewed; Region: PRK07846 935697003855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935697003856 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935697003857 cobyric acid synthase; Provisional; Region: PRK00784 935697003858 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 935697003859 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 935697003860 catalytic triad [active] 935697003861 methionine aminopeptidase; Provisional; Region: PRK12318 935697003862 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 935697003863 active site 935697003864 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 935697003865 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935697003866 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 935697003867 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935697003868 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935697003869 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 935697003870 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 935697003871 active site 935697003872 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935697003873 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 935697003874 putative substrate binding region [chemical binding]; other site 935697003875 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 935697003876 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 935697003877 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 935697003878 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 935697003879 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 935697003880 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 935697003881 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 935697003882 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 935697003883 ribosome recycling factor; Reviewed; Region: frr; PRK00083 935697003884 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 935697003885 hinge region; other site 935697003886 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 935697003887 putative nucleotide binding site [chemical binding]; other site 935697003888 uridine monophosphate binding site [chemical binding]; other site 935697003889 homohexameric interface [polypeptide binding]; other site 935697003890 elongation factor Ts; Provisional; Region: tsf; PRK09377 935697003891 UBA/TS-N domain; Region: UBA; pfam00627 935697003892 Elongation factor TS; Region: EF_TS; pfam00889 935697003893 Elongation factor TS; Region: EF_TS; pfam00889 935697003894 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 935697003895 rRNA interaction site [nucleotide binding]; other site 935697003896 S8 interaction site; other site 935697003897 putative laminin-1 binding site; other site 935697003898 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 935697003899 Peptidase family M23; Region: Peptidase_M23; pfam01551 935697003900 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 935697003901 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 935697003902 active site 935697003903 DNA binding site [nucleotide binding] 935697003904 Int/Topo IB signature motif; other site 935697003905 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 935697003906 DNA protecting protein DprA; Region: dprA; TIGR00732 935697003907 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 935697003908 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 935697003909 RNA/DNA hybrid binding site [nucleotide binding]; other site 935697003910 active site 935697003911 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 935697003912 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935697003913 Catalytic site [active] 935697003914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935697003915 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 935697003916 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 935697003917 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 935697003918 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 935697003919 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 935697003920 RNA binding site [nucleotide binding]; other site 935697003921 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 935697003922 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 935697003923 active site 935697003924 P-loop; other site 935697003925 phosphorylation site [posttranslational modification] 935697003926 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 935697003927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 935697003928 active site 935697003929 phosphorylation site [posttranslational modification] 935697003930 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 935697003931 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 935697003932 RimM N-terminal domain; Region: RimM; pfam01782 935697003933 PRC-barrel domain; Region: PRC; pfam05239 935697003934 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 935697003935 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 935697003936 signal recognition particle protein; Provisional; Region: PRK10867 935697003937 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 935697003938 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935697003939 P loop; other site 935697003940 GTP binding site [chemical binding]; other site 935697003941 Signal peptide binding domain; Region: SRP_SPB; pfam02978 935697003942 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 935697003943 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935697003944 metal binding triad; other site 935697003945 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935697003946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935697003947 Zn2+ binding site [ion binding]; other site 935697003948 Mg2+ binding site [ion binding]; other site 935697003949 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 935697003950 Nitrogen regulatory protein P-II; Region: P-II; smart00938 935697003951 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 935697003952 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 935697003953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 935697003954 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 935697003955 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935697003956 Walker A/P-loop; other site 935697003957 ATP binding site [chemical binding]; other site 935697003958 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 935697003959 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935697003960 ABC transporter signature motif; other site 935697003961 Walker B; other site 935697003962 D-loop; other site 935697003963 H-loop/switch region; other site 935697003964 Acylphosphatase; Region: Acylphosphatase; cl00551 935697003965 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935697003966 amino acid carrier protein; Region: agcS; TIGR00835 935697003967 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 935697003968 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 935697003969 DNA binding site [nucleotide binding] 935697003970 catalytic residue [active] 935697003971 H2TH interface [polypeptide binding]; other site 935697003972 putative catalytic residues [active] 935697003973 turnover-facilitating residue; other site 935697003974 intercalation triad [nucleotide binding]; other site 935697003975 8OG recognition residue [nucleotide binding]; other site 935697003976 putative reading head residues; other site 935697003977 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 935697003978 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935697003979 ribonuclease III; Reviewed; Region: rnc; PRK00102 935697003980 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 935697003981 dimerization interface [polypeptide binding]; other site 935697003982 active site 935697003983 metal binding site [ion binding]; metal-binding site 935697003984 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 935697003985 dsRNA binding site [nucleotide binding]; other site 935697003986 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 935697003987 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 935697003988 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 935697003989 RibD C-terminal domain; Region: RibD_C; cl17279 935697003990 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 935697003991 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 935697003992 hexamer interface [polypeptide binding]; other site 935697003993 ligand binding site [chemical binding]; other site 935697003994 putative active site [active] 935697003995 NAD(P) binding site [chemical binding]; other site 935697003996 glutamate dehydrogenase; Provisional; Region: PRK09414 935697003997 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935697003998 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 935697003999 NAD(P) binding site [chemical binding]; other site 935697004000 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 935697004001 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 935697004002 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 935697004003 nucleotide binding site/active site [active] 935697004004 HIT family signature motif; other site 935697004005 catalytic residue [active] 935697004006 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 935697004007 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 935697004008 metal binding site [ion binding]; metal-binding site 935697004009 putative dimer interface [polypeptide binding]; other site 935697004010 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 935697004011 homodimer interface [polypeptide binding]; other site 935697004012 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 935697004013 active site pocket [active] 935697004014 Electron transfer DM13; Region: DM13; pfam10517 935697004015 pyruvate kinase; Provisional; Region: PRK06247 935697004016 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 935697004017 domain interfaces; other site 935697004018 active site 935697004019 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 935697004020 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 935697004021 active site 935697004022 ribulose/triose binding site [chemical binding]; other site 935697004023 phosphate binding site [ion binding]; other site 935697004024 substrate (anthranilate) binding pocket [chemical binding]; other site 935697004025 product (indole) binding pocket [chemical binding]; other site 935697004026 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 935697004027 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 935697004028 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 935697004029 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935697004030 substrate binding site [chemical binding]; other site 935697004031 glutamase interaction surface [polypeptide binding]; other site 935697004032 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 935697004033 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935697004034 active site 935697004035 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 935697004036 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935697004037 catalytic residues [active] 935697004038 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 935697004039 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 935697004040 putative active site [active] 935697004041 oxyanion strand; other site 935697004042 catalytic triad [active] 935697004043 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 935697004044 putative active site pocket [active] 935697004045 4-fold oligomerization interface [polypeptide binding]; other site 935697004046 metal binding residues [ion binding]; metal-binding site 935697004047 3-fold/trimer interface [polypeptide binding]; other site 935697004048 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 935697004049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697004050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004051 homodimer interface [polypeptide binding]; other site 935697004052 catalytic residue [active] 935697004053 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 935697004054 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 935697004055 NAD binding site [chemical binding]; other site 935697004056 dimerization interface [polypeptide binding]; other site 935697004057 product binding site; other site 935697004058 substrate binding site [chemical binding]; other site 935697004059 zinc binding site [ion binding]; other site 935697004060 catalytic residues [active] 935697004061 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 935697004062 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 935697004063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697004064 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 935697004065 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 935697004066 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 935697004067 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 935697004068 active site 935697004069 catalytic site [active] 935697004070 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 935697004071 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 935697004072 active site 935697004073 catalytic site [active] 935697004074 substrate binding site [chemical binding]; other site 935697004075 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 935697004076 Dimer interface [polypeptide binding]; other site 935697004077 BRCT sequence motif; other site 935697004078 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935697004079 synthetase active site [active] 935697004080 NTP binding site [chemical binding]; other site 935697004081 metal binding site [ion binding]; metal-binding site 935697004082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697004083 RNA binding surface [nucleotide binding]; other site 935697004084 Uncharacterized conserved protein [Function unknown]; Region: COG1739 935697004085 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 935697004086 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 935697004087 threonine dehydratase; Validated; Region: PRK08639 935697004088 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 935697004089 tetramer interface [polypeptide binding]; other site 935697004090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004091 catalytic residue [active] 935697004092 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 935697004093 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 935697004094 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 935697004095 active site 935697004096 PHP Thumb interface [polypeptide binding]; other site 935697004097 metal binding site [ion binding]; metal-binding site 935697004098 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 935697004099 generic binding surface I; other site 935697004100 generic binding surface II; other site 935697004101 Predicted permeases [General function prediction only]; Region: RarD; COG2962 935697004102 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935697004103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935697004104 RNA binding surface [nucleotide binding]; other site 935697004105 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935697004106 active site 935697004107 lipoprotein signal peptidase; Provisional; Region: PRK14764 935697004108 lipoprotein signal peptidase; Provisional; Region: PRK14787 935697004109 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 935697004110 active site 935697004111 homotetramer interface [polypeptide binding]; other site 935697004112 homodimer interface [polypeptide binding]; other site 935697004113 DNA polymerase IV; Provisional; Region: PRK03348 935697004114 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 935697004115 active site 935697004116 DNA binding site [nucleotide binding] 935697004117 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 935697004118 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 935697004119 HIGH motif; other site 935697004120 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 935697004121 active site 935697004122 KMSKS motif; other site 935697004123 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 935697004124 tRNA binding surface [nucleotide binding]; other site 935697004125 anticodon binding site; other site 935697004126 DivIVA protein; Region: DivIVA; pfam05103 935697004127 DivIVA domain; Region: DivI1A_domain; TIGR03544 935697004128 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 935697004129 YGGT family; Region: YGGT; pfam02325 935697004130 Protein of unknown function (DUF552); Region: DUF552; cl00775 935697004131 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 935697004132 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 935697004133 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 935697004134 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 935697004135 nucleotide binding site [chemical binding]; other site 935697004136 SulA interaction site; other site 935697004137 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 935697004138 Cell division protein FtsQ; Region: FtsQ; pfam03799 935697004139 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 935697004140 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935697004141 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697004142 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935697004143 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 935697004144 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 935697004145 homodimer interface [polypeptide binding]; other site 935697004146 active site 935697004147 cell division protein FtsW; Region: ftsW; TIGR02614 935697004148 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 935697004149 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697004150 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 935697004151 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 935697004152 Mg++ binding site [ion binding]; other site 935697004153 putative catalytic motif [active] 935697004154 putative substrate binding site [chemical binding]; other site 935697004155 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 935697004156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935697004157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697004158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935697004159 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 935697004160 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935697004161 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697004162 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935697004163 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 935697004164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 935697004165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935697004166 MraW methylase family; Region: Methyltransf_5; cl17771 935697004167 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 935697004168 cell division protein MraZ; Reviewed; Region: PRK00326 935697004169 MraZ protein; Region: MraZ; pfam02381 935697004170 MraZ protein; Region: MraZ; pfam02381 935697004171 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 935697004172 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 935697004173 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 935697004174 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 935697004175 FAD binding site [chemical binding]; other site 935697004176 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935697004177 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935697004178 substrate binding pocket [chemical binding]; other site 935697004179 chain length determination region; other site 935697004180 substrate-Mg2+ binding site; other site 935697004181 catalytic residues [active] 935697004182 aspartate-rich region 1; other site 935697004183 active site lid residues [active] 935697004184 aspartate-rich region 2; other site 935697004185 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 935697004186 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 935697004187 Catalytic domain of Protein Kinases; Region: PKc; cd00180 935697004188 active site 935697004189 ATP binding site [chemical binding]; other site 935697004190 substrate binding site [chemical binding]; other site 935697004191 activation loop (A-loop); other site 935697004192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 935697004193 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697004194 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697004195 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697004196 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697004197 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 935697004198 Predicted membrane protein [Function unknown]; Region: COG4763 935697004199 Acyltransferase family; Region: Acyl_transf_3; pfam01757 935697004200 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 935697004201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 935697004202 nucleotide binding site [chemical binding]; other site 935697004203 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935697004204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935697004205 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935697004206 NlpC/P60 family; Region: NLPC_P60; pfam00877 935697004207 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935697004208 NlpC/P60 family; Region: NLPC_P60; pfam00877 935697004209 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 935697004210 heme bH binding site [chemical binding]; other site 935697004211 intrachain domain interface; other site 935697004212 heme bL binding site [chemical binding]; other site 935697004213 interchain domain interface [polypeptide binding]; other site 935697004214 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 935697004215 Qo binding site; other site 935697004216 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 935697004217 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 935697004218 iron-sulfur cluster [ion binding]; other site 935697004219 [2Fe-2S] cluster binding site [ion binding]; other site 935697004220 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 935697004221 Cytochrome c; Region: Cytochrom_C; pfam00034 935697004222 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 935697004223 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 935697004224 Subunit I/III interface [polypeptide binding]; other site 935697004225 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 935697004226 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 935697004227 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 935697004228 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 935697004229 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 935697004230 active site 935697004231 dimer interface [polypeptide binding]; other site 935697004232 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 935697004233 Ligand Binding Site [chemical binding]; other site 935697004234 Molecular Tunnel; other site 935697004235 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 935697004236 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 935697004237 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 935697004238 homotrimer interface [polypeptide binding]; other site 935697004239 Walker A motif; other site 935697004240 GTP binding site [chemical binding]; other site 935697004241 Walker B motif; other site 935697004242 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 935697004243 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 935697004244 putative dimer interface [polypeptide binding]; other site 935697004245 active site pocket [active] 935697004246 putative cataytic base [active] 935697004247 cobalamin synthase; Reviewed; Region: cobS; PRK00235 935697004248 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 935697004249 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 935697004250 homodimer interface [polypeptide binding]; other site 935697004251 substrate-cofactor binding pocket; other site 935697004252 catalytic residue [active] 935697004253 multifunctional aminopeptidase A; Provisional; Region: PRK00913 935697004254 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 935697004255 interface (dimer of trimers) [polypeptide binding]; other site 935697004256 Substrate-binding/catalytic site; other site 935697004257 Zn-binding sites [ion binding]; other site 935697004258 glycine dehydrogenase; Provisional; Region: PRK05367 935697004259 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935697004260 tetramer interface [polypeptide binding]; other site 935697004261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004262 catalytic residue [active] 935697004263 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935697004264 tetramer interface [polypeptide binding]; other site 935697004265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004266 catalytic residue [active] 935697004267 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 935697004268 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 935697004269 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 935697004270 lipoyl attachment site [posttranslational modification]; other site 935697004271 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 935697004272 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935697004273 active site 935697004274 lipoate-protein ligase B; Provisional; Region: PRK14345 935697004275 lipoyl synthase; Provisional; Region: PRK05481 935697004276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697004277 FeS/SAM binding site; other site 935697004278 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 935697004279 RDD family; Region: RDD; pfam06271 935697004280 glutamine synthetase, type I; Region: GlnA; TIGR00653 935697004281 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 935697004282 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 935697004283 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 935697004284 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 935697004285 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935697004286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935697004287 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935697004288 Htaa; Region: HtaA; pfam04213 935697004289 Htaa; Region: HtaA; pfam04213 935697004290 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 935697004291 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 935697004292 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 935697004293 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 935697004294 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 935697004295 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 935697004296 active site 935697004297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 935697004298 Predicted permease [General function prediction only]; Region: COG2056 935697004299 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 935697004300 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 935697004301 nudix motif; other site 935697004302 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 935697004303 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 935697004304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004305 catalytic residue [active] 935697004306 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 935697004307 active site 935697004308 catalytic site [active] 935697004309 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 935697004310 heme binding pocket [chemical binding]; other site 935697004311 heme ligand [chemical binding]; other site 935697004312 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 935697004313 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935697004314 metal binding triad; other site 935697004315 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935697004316 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935697004317 metal binding triad; other site 935697004318 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935697004319 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 935697004320 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 935697004321 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 935697004322 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 935697004323 putative active site; other site 935697004324 putative metal binding residues [ion binding]; other site 935697004325 signature motif; other site 935697004326 putative triphosphate binding site [ion binding]; other site 935697004327 CHAD domain; Region: CHAD; pfam05235 935697004328 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 935697004329 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 935697004330 RNB domain; Region: RNB; pfam00773 935697004331 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 935697004332 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 935697004333 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 935697004334 RNA/DNA hybrid binding site [nucleotide binding]; other site 935697004335 active site 935697004336 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697004337 catalytic core [active] 935697004338 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 935697004339 Putative zinc ribbon domain; Region: DUF164; pfam02591 935697004340 Uncharacterized conserved protein [Function unknown]; Region: COG0327 935697004341 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 935697004342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 935697004343 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 935697004344 hypothetical protein; Provisional; Region: PRK07908 935697004345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697004346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004347 homodimer interface [polypeptide binding]; other site 935697004348 catalytic residue [active] 935697004349 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935697004350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697004351 motif II; other site 935697004352 Low molecular weight phosphatase family; Region: LMWPc; cl00105 935697004353 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 935697004354 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 935697004355 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 935697004356 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 935697004357 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 935697004358 dimer interface [polypeptide binding]; other site 935697004359 TPP-binding site [chemical binding]; other site 935697004360 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 935697004361 Serine hydrolase; Region: Ser_hydrolase; cl17834 935697004362 Phosphopantetheine attachment site; Region: PP-binding; cl09936 935697004363 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 935697004364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697004365 active site 935697004366 motif I; other site 935697004367 motif II; other site 935697004368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697004369 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 935697004370 Beta-lactamase; Region: Beta-lactamase; pfam00144 935697004371 Predicted membrane protein [Function unknown]; Region: COG2860 935697004372 UPF0126 domain; Region: UPF0126; pfam03458 935697004373 UPF0126 domain; Region: UPF0126; pfam03458 935697004374 DNA primase; Validated; Region: dnaG; PRK05667 935697004375 CHC2 zinc finger; Region: zf-CHC2; pfam01807 935697004376 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 935697004377 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 935697004378 active site 935697004379 metal binding site [ion binding]; metal-binding site 935697004380 interdomain interaction site; other site 935697004381 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 935697004382 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 935697004383 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 935697004384 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 935697004385 glutaminase active site [active] 935697004386 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 935697004387 dimer interface [polypeptide binding]; other site 935697004388 active site 935697004389 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 935697004390 dimer interface [polypeptide binding]; other site 935697004391 active site 935697004392 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 935697004393 active site 935697004394 barstar interaction site; other site 935697004395 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 935697004396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935697004397 Zn2+ binding site [ion binding]; other site 935697004398 Mg2+ binding site [ion binding]; other site 935697004399 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 935697004400 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 935697004401 putative active site [active] 935697004402 Repair protein; Region: Repair_PSII; pfam04536 935697004403 glycyl-tRNA synthetase; Provisional; Region: PRK04173 935697004404 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935697004405 motif 1; other site 935697004406 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 935697004407 active site 935697004408 motif 2; other site 935697004409 motif 3; other site 935697004410 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 935697004411 anticodon binding site; other site 935697004412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935697004413 putative DNA binding site [nucleotide binding]; other site 935697004414 putative Zn2+ binding site [ion binding]; other site 935697004415 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 935697004416 metal binding site 2 [ion binding]; metal-binding site 935697004417 putative DNA binding helix; other site 935697004418 metal binding site 1 [ion binding]; metal-binding site 935697004419 dimer interface [polypeptide binding]; other site 935697004420 structural Zn2+ binding site [ion binding]; other site 935697004421 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 935697004422 diiron binding motif [ion binding]; other site 935697004423 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 935697004424 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 935697004425 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 935697004426 putative FPP binding hydrophobic cleft; other site 935697004427 dimer interface [polypeptide binding]; other site 935697004428 putative IPP diphosphate binding site; other site 935697004429 Recombination protein O N terminal; Region: RecO_N; pfam11967 935697004430 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 935697004431 Recombination protein O C terminal; Region: RecO_C; pfam02565 935697004432 GTPase Era; Reviewed; Region: era; PRK00089 935697004433 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 935697004434 G1 box; other site 935697004435 GTP/Mg2+ binding site [chemical binding]; other site 935697004436 Switch I region; other site 935697004437 G2 box; other site 935697004438 Switch II region; other site 935697004439 G3 box; other site 935697004440 G4 box; other site 935697004441 G5 box; other site 935697004442 KH domain; Region: KH_2; pfam07650 935697004443 pyridoxamine kinase; Validated; Region: PRK05756 935697004444 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 935697004445 dimer interface [polypeptide binding]; other site 935697004446 pyridoxal binding site [chemical binding]; other site 935697004447 ATP binding site [chemical binding]; other site 935697004448 Domain of unknown function DUF21; Region: DUF21; pfam01595 935697004449 FOG: CBS domain [General function prediction only]; Region: COG0517 935697004450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935697004451 Transporter associated domain; Region: CorC_HlyC; smart01091 935697004452 metal-binding heat shock protein; Provisional; Region: PRK00016 935697004453 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 935697004454 PhoH-like protein; Region: PhoH; pfam02562 935697004455 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 935697004456 RNA methyltransferase, RsmE family; Region: TIGR00046 935697004457 chaperone protein DnaJ; Provisional; Region: PRK14278 935697004458 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935697004459 HSP70 interaction site [polypeptide binding]; other site 935697004460 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 935697004461 Zn binding sites [ion binding]; other site 935697004462 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 935697004463 dimer interface [polypeptide binding]; other site 935697004464 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 935697004465 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 935697004466 coproporphyrinogen III oxidase; Validated; Region: PRK05628 935697004467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935697004468 FeS/SAM binding site; other site 935697004469 HemN C-terminal domain; Region: HemN_C; pfam06969 935697004470 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 935697004471 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 935697004472 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 935697004473 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 935697004474 substrate binding pocket [chemical binding]; other site 935697004475 catalytic triad [active] 935697004476 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 935697004477 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 935697004478 active site 935697004479 metal binding site [ion binding]; metal-binding site 935697004480 nudix motif; other site 935697004481 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 935697004482 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 935697004483 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 935697004484 BCCT family transporter; Region: BCCT; pfam02028 935697004485 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 935697004486 Predicted permeases [General function prediction only]; Region: COG0679 935697004487 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 935697004488 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 935697004489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697004490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697004491 dimer interface [polypeptide binding]; other site 935697004492 conserved gate region; other site 935697004493 putative PBP binding loops; other site 935697004494 ABC-ATPase subunit interface; other site 935697004495 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 935697004496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697004497 dimer interface [polypeptide binding]; other site 935697004498 conserved gate region; other site 935697004499 putative PBP binding loops; other site 935697004500 ABC-ATPase subunit interface; other site 935697004501 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 935697004502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697004503 Walker A/P-loop; other site 935697004504 ATP binding site [chemical binding]; other site 935697004505 Q-loop/lid; other site 935697004506 ABC transporter signature motif; other site 935697004507 Walker B; other site 935697004508 D-loop; other site 935697004509 H-loop/switch region; other site 935697004510 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697004511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697004512 Walker A/P-loop; other site 935697004513 ATP binding site [chemical binding]; other site 935697004514 Q-loop/lid; other site 935697004515 ABC transporter signature motif; other site 935697004516 Walker B; other site 935697004517 D-loop; other site 935697004518 H-loop/switch region; other site 935697004519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697004520 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 935697004521 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 935697004522 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935697004523 catalytic residue [active] 935697004524 Sulphur transport; Region: Sulf_transp; pfam04143 935697004525 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 935697004526 CPxP motif; other site 935697004527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697004528 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 935697004529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 935697004530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 935697004531 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 935697004532 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 935697004533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935697004534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697004535 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 935697004536 Walker A/P-loop; other site 935697004537 ATP binding site [chemical binding]; other site 935697004538 Q-loop/lid; other site 935697004539 ABC transporter signature motif; other site 935697004540 Walker B; other site 935697004541 D-loop; other site 935697004542 H-loop/switch region; other site 935697004543 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 935697004544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697004545 Walker A/P-loop; other site 935697004546 ATP binding site [chemical binding]; other site 935697004547 Q-loop/lid; other site 935697004548 ABC transporter signature motif; other site 935697004549 Walker B; other site 935697004550 D-loop; other site 935697004551 H-loop/switch region; other site 935697004552 GTP-binding protein LepA; Provisional; Region: PRK05433 935697004553 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 935697004554 G1 box; other site 935697004555 putative GEF interaction site [polypeptide binding]; other site 935697004556 GTP/Mg2+ binding site [chemical binding]; other site 935697004557 Switch I region; other site 935697004558 G2 box; other site 935697004559 G3 box; other site 935697004560 Switch II region; other site 935697004561 G4 box; other site 935697004562 G5 box; other site 935697004563 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 935697004564 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 935697004565 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 935697004566 PemK-like protein; Region: PemK; pfam02452 935697004567 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 935697004568 LysE type translocator; Region: LysE; cl00565 935697004569 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 935697004570 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 935697004571 hypothetical protein; Validated; Region: PRK05629 935697004572 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 935697004573 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 935697004574 Competence protein; Region: Competence; pfam03772 935697004575 comEA protein; Region: comE; TIGR01259 935697004576 Helix-hairpin-helix motif; Region: HHH; pfam00633 935697004577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 935697004578 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 935697004579 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697004580 catalytic core [active] 935697004581 Oligomerisation domain; Region: Oligomerisation; pfam02410 935697004582 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 935697004583 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 935697004584 active site 935697004585 (T/H)XGH motif; other site 935697004586 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 935697004587 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 935697004588 putative catalytic cysteine [active] 935697004589 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 935697004590 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 935697004591 putative ligand binding site [chemical binding]; other site 935697004592 putative NAD binding site [chemical binding]; other site 935697004593 catalytic site [active] 935697004594 Protein of unknown function (DUF454); Region: DUF454; cl01063 935697004595 Predicted permease [General function prediction only]; Region: COG2985 935697004596 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 935697004597 TrkA-C domain; Region: TrkA_C; pfam02080 935697004598 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 935697004599 GTPase CgtA; Reviewed; Region: obgE; PRK12296 935697004600 GTP1/OBG; Region: GTP1_OBG; pfam01018 935697004601 Obg GTPase; Region: Obg; cd01898 935697004602 G1 box; other site 935697004603 GTP/Mg2+ binding site [chemical binding]; other site 935697004604 Switch I region; other site 935697004605 G2 box; other site 935697004606 G3 box; other site 935697004607 Switch II region; other site 935697004608 G4 box; other site 935697004609 G5 box; other site 935697004610 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 935697004611 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 935697004612 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 935697004613 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 935697004614 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935697004615 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 935697004616 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935697004617 homodimer interface [polypeptide binding]; other site 935697004618 oligonucleotide binding site [chemical binding]; other site 935697004619 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 935697004620 active site 935697004621 multimer interface [polypeptide binding]; other site 935697004622 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 935697004623 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 935697004624 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 935697004625 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 935697004626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697004627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935697004628 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935697004629 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 935697004630 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697004631 active site 935697004632 HIGH motif; other site 935697004633 nucleotide binding site [chemical binding]; other site 935697004634 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935697004635 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935697004636 active site 935697004637 KMSKS motif; other site 935697004638 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 935697004639 tRNA binding surface [nucleotide binding]; other site 935697004640 anticodon binding site; other site 935697004641 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 935697004642 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 935697004643 malate dehydrogenase; Provisional; Region: PRK05442 935697004644 NAD(P) binding site [chemical binding]; other site 935697004645 dimer interface [polypeptide binding]; other site 935697004646 malate binding site [chemical binding]; other site 935697004647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697004648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697004649 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 935697004650 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 935697004651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697004652 Walker A motif; other site 935697004653 ATP binding site [chemical binding]; other site 935697004654 Walker B motif; other site 935697004655 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 935697004656 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 935697004657 Glutamine amidotransferase class-I; Region: GATase; pfam00117 935697004658 glutamine binding [chemical binding]; other site 935697004659 catalytic triad [active] 935697004660 hypothetical protein; Validated; Region: PRK09070 935697004661 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 935697004662 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 935697004663 Aminotransferase class IV; Region: Aminotran_4; pfam01063 935697004664 substrate-cofactor binding pocket; other site 935697004665 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 935697004666 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 935697004667 oligomer interface [polypeptide binding]; other site 935697004668 active site residues [active] 935697004669 Clp protease; Region: CLP_protease; pfam00574 935697004670 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 935697004671 oligomer interface [polypeptide binding]; other site 935697004672 active site residues [active] 935697004673 trigger factor; Provisional; Region: tig; PRK01490 935697004674 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935697004675 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 935697004676 Pirin-related protein [General function prediction only]; Region: COG1741 935697004677 Pirin; Region: Pirin; pfam02678 935697004678 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 935697004679 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 935697004680 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 935697004681 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 935697004682 catalytic residues [active] 935697004683 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 935697004684 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 935697004685 Zn binding site [ion binding]; other site 935697004686 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935697004687 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 935697004688 apolar tunnel; other site 935697004689 heme binding site [chemical binding]; other site 935697004690 dimerization interface [polypeptide binding]; other site 935697004691 Protein of unknown function, DUF606; Region: DUF606; pfam04657 935697004692 Protein of unknown function, DUF606; Region: DUF606; pfam04657 935697004693 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 935697004694 active site 935697004695 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 935697004696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697004697 Walker A/P-loop; other site 935697004698 ATP binding site [chemical binding]; other site 935697004699 Q-loop/lid; other site 935697004700 ABC transporter signature motif; other site 935697004701 Walker B; other site 935697004702 D-loop; other site 935697004703 H-loop/switch region; other site 935697004704 ABC transporter; Region: ABC_tran_2; pfam12848 935697004705 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935697004706 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 935697004707 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 935697004708 dimer interface [polypeptide binding]; other site 935697004709 ssDNA binding site [nucleotide binding]; other site 935697004710 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935697004711 YcaO-like family; Region: YcaO; pfam02624 935697004712 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 935697004713 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 935697004714 NADPH bind site [chemical binding]; other site 935697004715 Nitroreductase family; Region: Nitroreductase; pfam00881 935697004716 dimer interface [polypeptide binding]; other site 935697004717 SpaB C-terminal domain; Region: SpaB_C; pfam14028 935697004718 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 935697004719 YcaO-like family; Region: YcaO; pfam02624 935697004720 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 935697004721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 935697004722 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 935697004723 Walker A/P-loop; other site 935697004724 ATP binding site [chemical binding]; other site 935697004725 Q-loop/lid; other site 935697004726 ABC transporter signature motif; other site 935697004727 Walker B; other site 935697004728 D-loop; other site 935697004729 H-loop/switch region; other site 935697004730 Copper resistance protein D; Region: CopD; pfam05425 935697004731 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 935697004732 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 935697004733 Carbon starvation protein CstA; Region: CstA; pfam02554 935697004734 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 935697004735 Protein of unknown function (DUF466); Region: DUF466; pfam04328 935697004736 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 935697004737 active site 935697004738 catalytic triad [active] 935697004739 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 935697004740 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 935697004741 NADP binding site [chemical binding]; other site 935697004742 dimer interface [polypeptide binding]; other site 935697004743 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 935697004744 classical (c) SDRs; Region: SDR_c; cd05233 935697004745 NAD(P) binding site [chemical binding]; other site 935697004746 active site 935697004747 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 935697004748 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 935697004749 catalytic site [active] 935697004750 putative active site [active] 935697004751 putative substrate binding site [chemical binding]; other site 935697004752 dimer interface [polypeptide binding]; other site 935697004753 N-acetylneuraminate lyase; Region: nanA; TIGR00683 935697004754 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 935697004755 inhibitor site; inhibition site 935697004756 active site 935697004757 dimer interface [polypeptide binding]; other site 935697004758 catalytic residue [active] 935697004759 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 935697004760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 935697004761 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 935697004762 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 935697004763 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 935697004764 Prostaglandin dehydrogenases; Region: PGDH; cd05288 935697004765 NAD(P) binding site [chemical binding]; other site 935697004766 substrate binding site [chemical binding]; other site 935697004767 dimer interface [polypeptide binding]; other site 935697004768 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 935697004769 Isochorismatase family; Region: Isochorismatase; pfam00857 935697004770 catalytic triad [active] 935697004771 metal binding site [ion binding]; metal-binding site 935697004772 conserved cis-peptide bond; other site 935697004773 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 935697004774 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 935697004775 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935697004776 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 935697004777 catalytic triad [active] 935697004778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697004779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697004780 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 935697004781 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 935697004782 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 935697004783 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 935697004784 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935697004785 phosphate binding site [ion binding]; other site 935697004786 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 935697004787 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 935697004788 active site 2 [active] 935697004789 active site 1 [active] 935697004790 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 935697004791 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 935697004792 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 935697004793 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 935697004794 putative NAD(P) binding site [chemical binding]; other site 935697004795 active site 935697004796 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 935697004797 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 935697004798 active site 935697004799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 935697004800 Histidine kinase; Region: HisKA_3; pfam07730 935697004801 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 935697004802 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935697004803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697004804 active site 935697004805 phosphorylation site [posttranslational modification] 935697004806 intermolecular recognition site; other site 935697004807 dimerization interface [polypeptide binding]; other site 935697004808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935697004809 DNA binding residues [nucleotide binding] 935697004810 dimerization interface [polypeptide binding]; other site 935697004811 Protein of unknown function (DUF418); Region: DUF418; pfam04235 935697004812 Glucitol operon activator protein (GutM); Region: GutM; cl01890 935697004813 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 935697004814 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 935697004815 active site 935697004816 dimerization interface [polypeptide binding]; other site 935697004817 ribonuclease PH; Reviewed; Region: rph; PRK00173 935697004818 Ribonuclease PH; Region: RNase_PH_bact; cd11362 935697004819 hexamer interface [polypeptide binding]; other site 935697004820 active site 935697004821 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 935697004822 glutamate racemase; Provisional; Region: PRK00865 935697004823 Rhomboid family; Region: Rhomboid; pfam01694 935697004824 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 935697004825 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 935697004826 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 935697004827 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 935697004828 active site 935697004829 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 935697004830 DEAD/DEAH box helicase; Region: DEAD; pfam00270 935697004831 ATP binding site [chemical binding]; other site 935697004832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935697004833 putative Mg++ binding site [ion binding]; other site 935697004834 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 935697004835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935697004836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 935697004837 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 935697004838 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 935697004839 phosphoserine phosphatase SerB; Region: serB; TIGR00338 935697004840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697004841 motif II; other site 935697004842 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 935697004843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 935697004844 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 935697004845 D-pathway; other site 935697004846 Putative ubiquinol binding site [chemical binding]; other site 935697004847 Low-spin heme (heme b) binding site [chemical binding]; other site 935697004848 Putative water exit pathway; other site 935697004849 Binuclear center (heme o3/CuB) [ion binding]; other site 935697004850 K-pathway; other site 935697004851 Putative proton exit pathway; other site 935697004852 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 935697004853 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 935697004854 dimer interface [polypeptide binding]; other site 935697004855 putative radical transfer pathway; other site 935697004856 diiron center [ion binding]; other site 935697004857 tyrosyl radical; other site 935697004858 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 935697004859 Ferritin-like domain; Region: Ferritin; pfam00210 935697004860 ferroxidase diiron center [ion binding]; other site 935697004861 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 935697004862 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 935697004863 Class I ribonucleotide reductase; Region: RNR_I; cd01679 935697004864 active site 935697004865 dimer interface [polypeptide binding]; other site 935697004866 catalytic residues [active] 935697004867 effector binding site; other site 935697004868 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 935697004869 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 935697004870 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 935697004871 catalytic residues [active] 935697004872 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 935697004873 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 935697004874 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 935697004875 homodimer interface [polypeptide binding]; other site 935697004876 NAD binding pocket [chemical binding]; other site 935697004877 ATP binding pocket [chemical binding]; other site 935697004878 Mg binding site [ion binding]; other site 935697004879 active-site loop [active] 935697004880 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 935697004881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935697004882 dimerization interface [polypeptide binding]; other site 935697004883 putative DNA binding site [nucleotide binding]; other site 935697004884 putative Zn2+ binding site [ion binding]; other site 935697004885 tRNA dimethylallyltransferase; Region: PLN02748 935697004886 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 935697004887 Thioredoxin; Region: Thioredoxin_4; cl17273 935697004888 Predicted membrane protein [Function unknown]; Region: COG2259 935697004889 phosphoglucomutase; Validated; Region: PRK07564 935697004890 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 935697004891 active site 935697004892 substrate binding site [chemical binding]; other site 935697004893 metal binding site [ion binding]; metal-binding site 935697004894 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 935697004895 CrcB-like protein; Region: CRCB; pfam02537 935697004896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935697004897 FtsX-like permease family; Region: FtsX; pfam02687 935697004898 FtsX-like permease family; Region: FtsX; pfam02687 935697004899 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935697004900 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 935697004901 Walker A/P-loop; other site 935697004902 ATP binding site [chemical binding]; other site 935697004903 Q-loop/lid; other site 935697004904 ABC transporter signature motif; other site 935697004905 Walker B; other site 935697004906 D-loop; other site 935697004907 H-loop/switch region; other site 935697004908 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 935697004909 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 935697004910 hinge; other site 935697004911 active site 935697004912 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 935697004913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935697004914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935697004915 DNA binding residues [nucleotide binding] 935697004916 dimerization interface [polypeptide binding]; other site 935697004917 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 935697004918 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 935697004919 dimer interface [polypeptide binding]; other site 935697004920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697004921 catalytic residue [active] 935697004922 serine O-acetyltransferase; Region: cysE; TIGR01172 935697004923 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 935697004924 trimer interface [polypeptide binding]; other site 935697004925 active site 935697004926 substrate binding site [chemical binding]; other site 935697004927 CoA binding site [chemical binding]; other site 935697004928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697004929 Coenzyme A binding pocket [chemical binding]; other site 935697004930 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 935697004931 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 935697004932 putative active site [active] 935697004933 metal binding site [ion binding]; metal-binding site 935697004934 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 935697004935 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 935697004936 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 935697004937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935697004938 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 935697004939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697004940 Walker A/P-loop; other site 935697004941 ATP binding site [chemical binding]; other site 935697004942 Q-loop/lid; other site 935697004943 ABC transporter signature motif; other site 935697004944 Walker B; other site 935697004945 D-loop; other site 935697004946 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 935697004947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935697004948 Walker A/P-loop; other site 935697004949 ATP binding site [chemical binding]; other site 935697004950 Q-loop/lid; other site 935697004951 ABC transporter signature motif; other site 935697004952 Walker B; other site 935697004953 D-loop; other site 935697004954 H-loop/switch region; other site 935697004955 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 935697004956 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 935697004957 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 935697004958 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 935697004959 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935697004960 FMN binding site [chemical binding]; other site 935697004961 active site 935697004962 catalytic residues [active] 935697004963 substrate binding site [chemical binding]; other site 935697004964 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 935697004965 PhoU domain; Region: PhoU; pfam01895 935697004966 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 935697004967 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 935697004968 Walker A/P-loop; other site 935697004969 ATP binding site [chemical binding]; other site 935697004970 Q-loop/lid; other site 935697004971 ABC transporter signature motif; other site 935697004972 Walker B; other site 935697004973 D-loop; other site 935697004974 H-loop/switch region; other site 935697004975 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 935697004976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697004977 dimer interface [polypeptide binding]; other site 935697004978 conserved gate region; other site 935697004979 putative PBP binding loops; other site 935697004980 ABC-ATPase subunit interface; other site 935697004981 PBP superfamily domain; Region: PBP_like_2; cl17296 935697004982 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 935697004983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697004984 Coenzyme A binding pocket [chemical binding]; other site 935697004985 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 935697004986 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 935697004987 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 935697004988 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 935697004989 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 935697004990 heme-binding site [chemical binding]; other site 935697004991 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 935697004992 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 935697004993 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 935697004994 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 935697004995 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 935697004996 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 935697004997 dimerization interface [polypeptide binding]; other site 935697004998 putative ATP binding site [chemical binding]; other site 935697004999 amidophosphoribosyltransferase; Provisional; Region: PRK07847 935697005000 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 935697005001 active site 935697005002 tetramer interface [polypeptide binding]; other site 935697005003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697005004 active site 935697005005 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 935697005006 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 935697005007 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 935697005008 dimer interface [polypeptide binding]; other site 935697005009 putative radical transfer pathway; other site 935697005010 diiron center [ion binding]; other site 935697005011 tyrosyl radical; other site 935697005012 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 935697005013 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 935697005014 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 935697005015 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 935697005016 dimerization interface [polypeptide binding]; other site 935697005017 ATP binding site [chemical binding]; other site 935697005018 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 935697005019 dimerization interface [polypeptide binding]; other site 935697005020 ATP binding site [chemical binding]; other site 935697005021 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 935697005022 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 935697005023 putative active site [active] 935697005024 catalytic triad [active] 935697005025 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 935697005026 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 935697005027 catalytic residues [active] 935697005028 dimer interface [polypeptide binding]; other site 935697005029 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 935697005030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935697005031 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 935697005032 ATP binding site [chemical binding]; other site 935697005033 active site 935697005034 substrate binding site [chemical binding]; other site 935697005035 adenylosuccinate lyase; Region: purB; TIGR00928 935697005036 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 935697005037 tetramer interface [polypeptide binding]; other site 935697005038 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 935697005039 TrkA-N domain; Region: TrkA_N; pfam02254 935697005040 TrkA-C domain; Region: TrkA_C; pfam02080 935697005041 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 935697005042 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 935697005043 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 935697005044 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 935697005045 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 935697005046 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 935697005047 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 935697005048 nucleotide binding site/active site [active] 935697005049 HIT family signature motif; other site 935697005050 catalytic residue [active] 935697005051 PGAP1-like protein; Region: PGAP1; pfam07819 935697005052 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 935697005053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935697005054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935697005055 dimerization interface [polypeptide binding]; other site 935697005056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935697005057 dimer interface [polypeptide binding]; other site 935697005058 phosphorylation site [posttranslational modification] 935697005059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697005060 ATP binding site [chemical binding]; other site 935697005061 Mg2+ binding site [ion binding]; other site 935697005062 G-X-G motif; other site 935697005063 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935697005064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697005065 active site 935697005066 phosphorylation site [posttranslational modification] 935697005067 intermolecular recognition site; other site 935697005068 dimerization interface [polypeptide binding]; other site 935697005069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935697005070 DNA binding site [nucleotide binding] 935697005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697005072 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 935697005073 putative substrate translocation pore; other site 935697005074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697005075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697005076 Predicted esterase [General function prediction only]; Region: COG0627 935697005077 S-formylglutathione hydrolase; Region: PLN02442 935697005078 xanthine permease; Region: pbuX; TIGR03173 935697005079 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 935697005080 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 935697005081 putative active site [active] 935697005082 pyruvate dehydrogenase; Provisional; Region: PRK06546 935697005083 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 935697005084 PYR/PP interface [polypeptide binding]; other site 935697005085 tetramer interface [polypeptide binding]; other site 935697005086 dimer interface [polypeptide binding]; other site 935697005087 TPP binding site [chemical binding]; other site 935697005088 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 935697005089 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 935697005090 TPP-binding site [chemical binding]; other site 935697005091 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 935697005092 Uncharacterized conserved protein [Function unknown]; Region: COG3610 935697005093 Uncharacterized conserved protein [Function unknown]; Region: COG2966 935697005094 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 935697005095 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 935697005096 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 935697005097 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 935697005098 active site 935697005099 homotetramer interface [polypeptide binding]; other site 935697005100 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 935697005101 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 935697005102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 935697005103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 935697005104 DNA binding site [nucleotide binding] 935697005105 domain linker motif; other site 935697005106 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 935697005107 putative dimerization interface [polypeptide binding]; other site 935697005108 putative ligand binding site [chemical binding]; other site 935697005109 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 935697005110 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935697005111 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 935697005112 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935697005113 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 935697005114 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697005115 active site 935697005116 HIGH motif; other site 935697005117 nucleotide binding site [chemical binding]; other site 935697005118 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935697005119 KMSKS motif; other site 935697005120 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 935697005121 tRNA binding surface [nucleotide binding]; other site 935697005122 anticodon binding site; other site 935697005123 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 935697005124 homotrimer interaction site [polypeptide binding]; other site 935697005125 zinc binding site [ion binding]; other site 935697005126 CDP-binding sites; other site 935697005127 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 935697005128 substrate binding site; other site 935697005129 dimer interface; other site 935697005130 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 935697005131 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935697005132 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935697005133 Walker A motif; other site 935697005134 ATP binding site [chemical binding]; other site 935697005135 Walker B motif; other site 935697005136 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935697005137 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 935697005138 active site clefts [active] 935697005139 zinc binding site [ion binding]; other site 935697005140 dimer interface [polypeptide binding]; other site 935697005141 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935697005142 endonuclease III; Region: ENDO3c; smart00478 935697005143 minor groove reading motif; other site 935697005144 helix-hairpin-helix signature motif; other site 935697005145 substrate binding pocket [chemical binding]; other site 935697005146 active site 935697005147 Uncharacterized conserved protein [Function unknown]; Region: COG2966 935697005148 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 935697005149 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 935697005150 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 935697005151 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 935697005152 Clp amino terminal domain; Region: Clp_N; pfam02861 935697005153 Clp amino terminal domain; Region: Clp_N; pfam02861 935697005154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697005155 Walker A motif; other site 935697005156 ATP binding site [chemical binding]; other site 935697005157 Walker B motif; other site 935697005158 arginine finger; other site 935697005159 UvrB/uvrC motif; Region: UVR; pfam02151 935697005160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697005161 Walker A motif; other site 935697005162 ATP binding site [chemical binding]; other site 935697005163 Walker B motif; other site 935697005164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935697005165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697005166 putative substrate translocation pore; other site 935697005167 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 935697005168 active site 935697005169 tetramer interface [polypeptide binding]; other site 935697005170 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 935697005171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 935697005172 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 935697005173 CAAX protease self-immunity; Region: Abi; pfam02517 935697005174 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 935697005175 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 935697005176 dimer interface [polypeptide binding]; other site 935697005177 putative anticodon binding site; other site 935697005178 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935697005179 motif 1; other site 935697005180 dimer interface [polypeptide binding]; other site 935697005181 active site 935697005182 motif 2; other site 935697005183 motif 3; other site 935697005184 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 935697005185 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 935697005186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 935697005187 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 935697005188 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 935697005189 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 935697005190 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935697005191 NAD(P) binding site [chemical binding]; other site 935697005192 catalytic residues [active] 935697005193 BCCT family transporter; Region: BCCT; cl00569 935697005194 choline dehydrogenase; Validated; Region: PRK02106 935697005195 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 935697005196 pantoate--beta-alanine ligase; Region: panC; TIGR00018 935697005197 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697005198 active site 935697005199 nucleotide binding site [chemical binding]; other site 935697005200 HIGH motif; other site 935697005201 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697005202 KMSKS motif; other site 935697005203 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 935697005204 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 935697005205 catalytic center binding site [active] 935697005206 ATP binding site [chemical binding]; other site 935697005207 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 935697005208 homooctamer interface [polypeptide binding]; other site 935697005209 active site 935697005210 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 935697005211 dihydropteroate synthase; Region: DHPS; TIGR01496 935697005212 substrate binding pocket [chemical binding]; other site 935697005213 dimer interface [polypeptide binding]; other site 935697005214 inhibitor binding site; inhibition site 935697005215 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 935697005216 GTP cyclohydrolase I; Provisional; Region: PLN03044 935697005217 homodecamer interface [polypeptide binding]; other site 935697005218 active site 935697005219 putative catalytic site residues [active] 935697005220 zinc binding site [ion binding]; other site 935697005221 GTP-CH-I/GFRP interaction surface; other site 935697005222 FtsH Extracellular; Region: FtsH_ext; pfam06480 935697005223 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 935697005224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935697005225 Walker A motif; other site 935697005226 ATP binding site [chemical binding]; other site 935697005227 Walker B motif; other site 935697005228 arginine finger; other site 935697005229 Peptidase family M41; Region: Peptidase_M41; pfam01434 935697005230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697005231 active site 935697005232 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 935697005233 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 935697005234 Ligand Binding Site [chemical binding]; other site 935697005235 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 935697005236 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 935697005237 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 935697005238 dimer interface [polypeptide binding]; other site 935697005239 substrate binding site [chemical binding]; other site 935697005240 metal binding sites [ion binding]; metal-binding site 935697005241 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 935697005242 active site residue [active] 935697005243 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 935697005244 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 935697005245 Secretory lipase; Region: LIP; pfam03583 935697005246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935697005247 MarR family; Region: MarR_2; pfam12802 935697005248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 935697005249 acyl-activating enzyme (AAE) consensus motif; other site 935697005250 AMP binding site [chemical binding]; other site 935697005251 active site 935697005252 CoA binding site [chemical binding]; other site 935697005253 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 935697005254 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 935697005255 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 935697005256 active site 935697005257 trimer interface [polypeptide binding]; other site 935697005258 substrate binding site [chemical binding]; other site 935697005259 CoA binding site [chemical binding]; other site 935697005260 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935697005261 putative trimer interface [polypeptide binding]; other site 935697005262 putative CoA binding site [chemical binding]; other site 935697005263 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 935697005264 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 935697005265 ring oligomerisation interface [polypeptide binding]; other site 935697005266 ATP/Mg binding site [chemical binding]; other site 935697005267 stacking interactions; other site 935697005268 hinge regions; other site 935697005269 hypothetical protein; Provisional; Region: PRK07907 935697005270 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 935697005271 active site 935697005272 metal binding site [ion binding]; metal-binding site 935697005273 dimer interface [polypeptide binding]; other site 935697005274 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 935697005275 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935697005276 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 935697005277 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 935697005278 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 935697005279 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 935697005280 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 935697005281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935697005282 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 935697005283 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 935697005284 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 935697005285 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 935697005286 carboxylate-amine ligase; Provisional; Region: PRK13517 935697005287 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 935697005288 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 935697005289 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 935697005290 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 935697005291 active site 935697005292 catalytic residues [active] 935697005293 metal binding site [ion binding]; metal-binding site 935697005294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935697005295 Coenzyme A binding pocket [chemical binding]; other site 935697005296 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 935697005297 putative catalytic site [active] 935697005298 putative phosphate binding site [ion binding]; other site 935697005299 active site 935697005300 metal binding site A [ion binding]; metal-binding site 935697005301 DNA binding site [nucleotide binding] 935697005302 putative AP binding site [nucleotide binding]; other site 935697005303 putative metal binding site B [ion binding]; other site 935697005304 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 935697005305 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 935697005306 putative active site [active] 935697005307 catalytic site [active] 935697005308 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 935697005309 putative active site [active] 935697005310 catalytic site [active] 935697005311 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 935697005312 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 935697005313 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 935697005314 Walker A/P-loop; other site 935697005315 ATP binding site [chemical binding]; other site 935697005316 Q-loop/lid; other site 935697005317 ABC transporter signature motif; other site 935697005318 Walker B; other site 935697005319 D-loop; other site 935697005320 H-loop/switch region; other site 935697005321 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 935697005322 nudix motif; other site 935697005323 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 935697005324 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935697005325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935697005326 substrate binding pocket [chemical binding]; other site 935697005327 membrane-bound complex binding site; other site 935697005328 hinge residues; other site 935697005329 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 935697005330 Catalytic domain of Protein Kinases; Region: PKc; cd00180 935697005331 active site 935697005332 ATP binding site [chemical binding]; other site 935697005333 substrate binding site [chemical binding]; other site 935697005334 activation loop (A-loop); other site 935697005335 propionate/acetate kinase; Provisional; Region: PRK12379 935697005336 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935697005337 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 935697005338 ferredoxin-NADP+ reductase; Region: PLN02852 935697005339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935697005340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 935697005341 Coenzyme A binding pocket [chemical binding]; other site 935697005342 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 935697005343 active site 935697005344 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935697005345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697005346 active site 935697005347 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 935697005348 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935697005349 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935697005350 catalytic residues [active] 935697005351 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 935697005352 ResB-like family; Region: ResB; pfam05140 935697005353 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 935697005354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935697005355 TPR motif; other site 935697005356 TPR repeat; Region: TPR_11; pfam13414 935697005357 binding surface 935697005358 Cytochrome c552; Region: Cytochrom_C552; pfam02335 935697005359 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 935697005360 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 935697005361 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 935697005362 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 935697005363 GDP-binding site [chemical binding]; other site 935697005364 ACT binding site; other site 935697005365 IMP binding site; other site 935697005366 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 935697005367 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 935697005368 Walker A/P-loop; other site 935697005369 ATP binding site [chemical binding]; other site 935697005370 Q-loop/lid; other site 935697005371 ABC transporter signature motif; other site 935697005372 Walker B; other site 935697005373 D-loop; other site 935697005374 H-loop/switch region; other site 935697005375 Predicted transcriptional regulators [Transcription]; Region: COG1695 935697005376 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 935697005377 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 935697005378 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 935697005379 active site 935697005380 intersubunit interface [polypeptide binding]; other site 935697005381 zinc binding site [ion binding]; other site 935697005382 Na+ binding site [ion binding]; other site 935697005383 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 935697005384 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935697005385 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935697005386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935697005387 active site 935697005388 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 935697005389 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 935697005390 active site residue [active] 935697005391 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 935697005392 active site residue [active] 935697005393 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 935697005394 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 935697005395 active site 935697005396 catalytic site [active] 935697005397 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 935697005398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 935697005399 Walker A/P-loop; other site 935697005400 ATP binding site [chemical binding]; other site 935697005401 Q-loop/lid; other site 935697005402 ABC transporter signature motif; other site 935697005403 Walker B; other site 935697005404 D-loop; other site 935697005405 H-loop/switch region; other site 935697005406 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 935697005407 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935697005408 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935697005409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935697005410 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935697005411 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 935697005412 FAD binding pocket [chemical binding]; other site 935697005413 conserved FAD binding motif [chemical binding]; other site 935697005414 phosphate binding motif [ion binding]; other site 935697005415 beta-alpha-beta structure motif; other site 935697005416 NAD binding pocket [chemical binding]; other site 935697005417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935697005418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 935697005419 FtsX-like permease family; Region: FtsX; pfam02687 935697005420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 935697005421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935697005422 Walker A/P-loop; other site 935697005423 ATP binding site [chemical binding]; other site 935697005424 Q-loop/lid; other site 935697005425 ABC transporter signature motif; other site 935697005426 Walker B; other site 935697005427 D-loop; other site 935697005428 H-loop/switch region; other site 935697005429 HlyD family secretion protein; Region: HlyD_3; pfam13437 935697005430 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 935697005431 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 935697005432 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 935697005433 NAD binding site [chemical binding]; other site 935697005434 substrate binding site [chemical binding]; other site 935697005435 catalytic Zn binding site [ion binding]; other site 935697005436 tetramer interface [polypeptide binding]; other site 935697005437 structural Zn binding site [ion binding]; other site 935697005438 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 935697005439 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935697005440 NAD(P) binding site [chemical binding]; other site 935697005441 catalytic residues [active] 935697005442 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 935697005443 active site 935697005444 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 935697005445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 935697005446 DNA binding residues [nucleotide binding] 935697005447 chaperone protein DnaJ; Provisional; Region: PRK14279 935697005448 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935697005449 HSP70 interaction site [polypeptide binding]; other site 935697005450 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 935697005451 Zn binding sites [ion binding]; other site 935697005452 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 935697005453 dimer interface [polypeptide binding]; other site 935697005454 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 935697005455 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 935697005456 dimer interface [polypeptide binding]; other site 935697005457 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 935697005458 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 935697005459 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 935697005460 nucleotide binding site [chemical binding]; other site 935697005461 NEF interaction site [polypeptide binding]; other site 935697005462 SBD interface [polypeptide binding]; other site 935697005463 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 935697005464 Domain of unknown function DUF20; Region: UPF0118; pfam01594 935697005465 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697005466 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 935697005467 Walker A/P-loop; other site 935697005468 ATP binding site [chemical binding]; other site 935697005469 Q-loop/lid; other site 935697005470 ABC transporter signature motif; other site 935697005471 Walker B; other site 935697005472 D-loop; other site 935697005473 H-loop/switch region; other site 935697005474 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 935697005475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697005476 putative PBP binding loops; other site 935697005477 dimer interface [polypeptide binding]; other site 935697005478 ABC-ATPase subunit interface; other site 935697005479 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 935697005480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697005481 Walker A/P-loop; other site 935697005482 ATP binding site [chemical binding]; other site 935697005483 Q-loop/lid; other site 935697005484 ABC transporter signature motif; other site 935697005485 Walker B; other site 935697005486 D-loop; other site 935697005487 H-loop/switch region; other site 935697005488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697005489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697005490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697005491 dimer interface [polypeptide binding]; other site 935697005492 conserved gate region; other site 935697005493 putative PBP binding loops; other site 935697005494 ABC-ATPase subunit interface; other site 935697005495 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 935697005496 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 935697005497 adrenodoxin reductase; Provisional; Region: PTZ00188 935697005498 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935697005499 4Fe-4S binding domain; Region: Fer4; cl02805 935697005500 4Fe-4S binding domain; Region: Fer4; pfam00037 935697005501 Cysteine-rich domain; Region: CCG; pfam02754 935697005502 Cysteine-rich domain; Region: CCG; pfam02754 935697005503 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 935697005504 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935697005505 dimerization interface [polypeptide binding]; other site 935697005506 putative DNA binding site [nucleotide binding]; other site 935697005507 putative Zn2+ binding site [ion binding]; other site 935697005508 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 935697005509 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697005510 Walker A/P-loop; other site 935697005511 ATP binding site [chemical binding]; other site 935697005512 Q-loop/lid; other site 935697005513 ABC transporter signature motif; other site 935697005514 Walker B; other site 935697005515 D-loop; other site 935697005516 H-loop/switch region; other site 935697005517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 935697005518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697005519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697005520 putative PBP binding regions; other site 935697005521 ABC-ATPase subunit interface; other site 935697005522 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 935697005523 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 935697005524 intersubunit interface [polypeptide binding]; other site 935697005525 UreD urease accessory protein; Region: UreD; cl00530 935697005526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 935697005527 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 935697005528 UreF; Region: UreF; pfam01730 935697005529 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 935697005530 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 935697005531 dimer interface [polypeptide binding]; other site 935697005532 catalytic residues [active] 935697005533 urease subunit alpha; Reviewed; Region: ureC; PRK13207 935697005534 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 935697005535 subunit interactions [polypeptide binding]; other site 935697005536 active site 935697005537 flap region; other site 935697005538 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 935697005539 gamma-beta subunit interface [polypeptide binding]; other site 935697005540 alpha-beta subunit interface [polypeptide binding]; other site 935697005541 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 935697005542 alpha-gamma subunit interface [polypeptide binding]; other site 935697005543 beta-gamma subunit interface [polypeptide binding]; other site 935697005544 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935697005545 EamA-like transporter family; Region: EamA; pfam00892 935697005546 EamA-like transporter family; Region: EamA; pfam00892 935697005547 aminotransferase AlaT; Validated; Region: PRK09265 935697005548 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935697005549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697005550 homodimer interface [polypeptide binding]; other site 935697005551 catalytic residue [active] 935697005552 YibE/F-like protein; Region: YibE_F; pfam07907 935697005553 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 935697005554 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 935697005555 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 935697005556 dimer interface [polypeptide binding]; other site 935697005557 putative anticodon binding site; other site 935697005558 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935697005559 motif 1; other site 935697005560 dimer interface [polypeptide binding]; other site 935697005561 active site 935697005562 motif 2; other site 935697005563 motif 3; other site 935697005564 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 935697005565 Protein of unknown function (DUF998); Region: DUF998; pfam06197 935697005566 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 935697005567 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 935697005568 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 935697005569 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935697005570 trimer interface [polypeptide binding]; other site 935697005571 active site 935697005572 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935697005573 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 935697005574 NAD(P) binding site [chemical binding]; other site 935697005575 catalytic residues [active] 935697005576 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 935697005577 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 935697005578 VanW like protein; Region: VanW; pfam04294 935697005579 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 935697005580 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 935697005581 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 935697005582 Acyltransferase family; Region: Acyl_transf_3; pfam01757 935697005583 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 935697005584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935697005585 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935697005586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697005587 S-adenosylmethionine binding site [chemical binding]; other site 935697005588 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 935697005589 active site 935697005590 substrate-binding site [chemical binding]; other site 935697005591 metal-binding site [ion binding] 935697005592 GTP binding site [chemical binding]; other site 935697005593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935697005594 S-adenosylmethionine binding site [chemical binding]; other site 935697005595 LabA_like proteins; Region: LabA_like; cd06167 935697005596 putative metal binding site [ion binding]; other site 935697005597 Predicted integral membrane protein [Function unknown]; Region: COG0392 935697005598 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 935697005599 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 935697005600 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935697005601 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 935697005602 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 935697005603 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935697005604 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 935697005605 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 935697005606 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 935697005607 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 935697005608 active site 935697005609 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 935697005610 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 935697005611 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 935697005612 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 935697005613 acyl-activating enzyme (AAE) consensus motif; other site 935697005614 active site 935697005615 Cutinase; Region: Cutinase; pfam01083 935697005616 Putative esterase; Region: Esterase; pfam00756 935697005617 S-formylglutathione hydrolase; Region: PLN02442 935697005618 LGFP repeat; Region: LGFP; pfam08310 935697005619 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 935697005620 LGFP repeat; Region: LGFP; pfam08310 935697005621 LGFP repeat; Region: LGFP; pfam08310 935697005622 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 935697005623 Predicted esterase [General function prediction only]; Region: COG0627 935697005624 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 935697005625 UbiA prenyltransferase family; Region: UbiA; pfam01040 935697005626 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 935697005627 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 935697005628 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 935697005629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 935697005630 Repair protein; Region: Repair_PSII; pfam04536 935697005631 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 935697005632 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 935697005633 active site 935697005634 catalytic site [active] 935697005635 metal binding site [ion binding]; metal-binding site 935697005636 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 935697005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697005638 putative substrate translocation pore; other site 935697005639 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 935697005640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935697005641 UDP-galactopyranose mutase; Region: GLF; pfam03275 935697005642 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 935697005643 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935697005644 Walker A/P-loop; other site 935697005645 ATP binding site [chemical binding]; other site 935697005646 Q-loop/lid; other site 935697005647 ABC transporter signature motif; other site 935697005648 Walker B; other site 935697005649 D-loop; other site 935697005650 H-loop/switch region; other site 935697005651 FecCD transport family; Region: FecCD; pfam01032 935697005652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935697005653 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935697005654 putative PBP binding regions; other site 935697005655 ABC-ATPase subunit interface; other site 935697005656 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 935697005657 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 935697005658 putative binding site residues; other site 935697005659 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 935697005660 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 935697005661 amidase catalytic site [active] 935697005662 Zn binding residues [ion binding]; other site 935697005663 substrate binding site [chemical binding]; other site 935697005664 LGFP repeat; Region: LGFP; pfam08310 935697005665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697005666 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 935697005667 active site 935697005668 motif I; other site 935697005669 motif II; other site 935697005670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935697005671 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935697005672 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935697005673 putative acyl-acceptor binding pocket; other site 935697005674 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 935697005675 seryl-tRNA synthetase; Provisional; Region: PRK05431 935697005676 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 935697005677 dimer interface [polypeptide binding]; other site 935697005678 active site 935697005679 motif 1; other site 935697005680 motif 2; other site 935697005681 motif 3; other site 935697005682 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 935697005683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935697005684 DNA-binding site [nucleotide binding]; DNA binding site 935697005685 UTRA domain; Region: UTRA; pfam07702 935697005686 Septum formation; Region: Septum_form; pfam13845 935697005687 Septum formation; Region: Septum_form; pfam13845 935697005688 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 935697005689 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935697005690 catalytic core [active] 935697005691 prephenate dehydratase; Provisional; Region: PRK11898 935697005692 Prephenate dehydratase; Region: PDT; pfam00800 935697005693 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 935697005694 putative L-Phe binding site [chemical binding]; other site 935697005695 Amidase; Region: Amidase; cl11426 935697005696 CAAX protease self-immunity; Region: Abi; pfam02517 935697005697 Transcriptional regulator [Transcription]; Region: LytR; COG1316 935697005698 Htaa; Region: HtaA; pfam04213 935697005699 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935697005700 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935697005701 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 935697005702 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 935697005703 catalytic triad [active] 935697005704 catalytic triad [active] 935697005705 oxyanion hole [active] 935697005706 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 935697005707 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 935697005708 putative active site [active] 935697005709 catalytic site [active] 935697005710 putative metal binding site [ion binding]; other site 935697005711 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 935697005712 active site 935697005713 catalytic motif [active] 935697005714 Zn binding site [ion binding]; other site 935697005715 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 935697005716 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 935697005717 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 935697005718 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 935697005719 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 935697005720 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 935697005721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935697005722 NAD binding site [chemical binding]; other site 935697005723 dimer interface [polypeptide binding]; other site 935697005724 substrate binding site [chemical binding]; other site 935697005725 methionine sulfoxide reductase A; Provisional; Region: PRK00058 935697005726 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 935697005727 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 935697005728 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 935697005729 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 935697005730 Predicted flavoprotein [General function prediction only]; Region: COG0431 935697005731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935697005732 putative substrate translocation pore; other site 935697005733 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 935697005734 Abi-like protein; Region: Abi_2; pfam07751 935697005735 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 935697005736 homodimer interface [polypeptide binding]; other site 935697005737 chemical substrate binding site [chemical binding]; other site 935697005738 oligomer interface [polypeptide binding]; other site 935697005739 metal binding site [ion binding]; metal-binding site 935697005740 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 935697005741 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 935697005742 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 935697005743 Lsr2; Region: Lsr2; pfam11774 935697005744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935697005745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697005746 active site 935697005747 phosphorylation site [posttranslational modification] 935697005748 intermolecular recognition site; other site 935697005749 dimerization interface [polypeptide binding]; other site 935697005750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935697005751 DNA binding residues [nucleotide binding] 935697005752 dimerization interface [polypeptide binding]; other site 935697005753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 935697005754 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 935697005755 Histidine kinase; Region: HisKA_3; pfam07730 935697005756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935697005757 ATP binding site [chemical binding]; other site 935697005758 Mg2+ binding site [ion binding]; other site 935697005759 G-X-G motif; other site 935697005760 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 935697005761 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 935697005762 active site 935697005763 catalytic site [active] 935697005764 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 935697005765 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 935697005766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935697005767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935697005768 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 935697005769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935697005770 Ligand Binding Site [chemical binding]; other site 935697005771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935697005772 Ligand Binding Site [chemical binding]; other site 935697005773 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 935697005774 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935697005775 active site 935697005776 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 935697005777 Predicted transcriptional regulators [Transcription]; Region: COG1725 935697005778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935697005779 DNA-binding site [nucleotide binding]; DNA binding site 935697005780 LabA_like proteins; Region: LabA_like; cd06167 935697005781 putative metal binding site [ion binding]; other site 935697005782 Uncharacterized conserved protein [Function unknown]; Region: COG1432 935697005783 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 935697005784 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 935697005785 catalytic residues [active] 935697005786 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935697005787 metal-binding site [ion binding] 935697005788 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935697005789 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935697005790 metal-binding site [ion binding] 935697005791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935697005792 replicative DNA helicase; Provisional; Region: PRK05636 935697005793 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 935697005794 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 935697005795 Walker A motif; other site 935697005796 ATP binding site [chemical binding]; other site 935697005797 Walker B motif; other site 935697005798 DNA binding loops [nucleotide binding] 935697005799 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 935697005800 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 935697005801 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 935697005802 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 935697005803 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 935697005804 dimer interface [polypeptide binding]; other site 935697005805 ssDNA binding site [nucleotide binding]; other site 935697005806 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935697005807 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 935697005808 Predicted integral membrane protein [Function unknown]; Region: COG5650 935697005809 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 935697005810 Transglycosylase; Region: Transgly; pfam00912 935697005811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 935697005812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935697005813 MarR family; Region: MarR; pfam01047 935697005814 MarR family; Region: MarR_2; cl17246 935697005815 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935697005816 Ligand Binding Site [chemical binding]; other site 935697005817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935697005818 Ligand Binding Site [chemical binding]; other site 935697005819 short chain dehydrogenase; Provisional; Region: PRK08219 935697005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935697005821 NAD(P) binding site [chemical binding]; other site 935697005822 active site 935697005823 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 935697005824 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 935697005825 active site residue [active] 935697005826 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 935697005827 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 935697005828 dimerization interface [polypeptide binding]; other site 935697005829 DPS ferroxidase diiron center [ion binding]; other site 935697005830 ion pore; other site 935697005831 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 935697005832 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 935697005833 putative DNA binding site [nucleotide binding]; other site 935697005834 catalytic residue [active] 935697005835 putative H2TH interface [polypeptide binding]; other site 935697005836 putative catalytic residues [active] 935697005837 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 935697005838 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935697005839 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 935697005840 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 935697005841 putative substrate binding site [chemical binding]; other site 935697005842 putative ATP binding site [chemical binding]; other site 935697005843 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 935697005844 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 935697005845 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 935697005846 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 935697005847 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 935697005848 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 935697005849 HIGH motif; other site 935697005850 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935697005851 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697005852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935697005853 active site 935697005854 KMSKS motif; other site 935697005855 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 935697005856 tRNA binding surface [nucleotide binding]; other site 935697005857 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 935697005858 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935697005859 Walker A/P-loop; other site 935697005860 ATP binding site [chemical binding]; other site 935697005861 Q-loop/lid; other site 935697005862 ABC transporter signature motif; other site 935697005863 Walker B; other site 935697005864 D-loop; other site 935697005865 H-loop/switch region; other site 935697005866 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935697005867 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 935697005868 FtsX-like permease family; Region: FtsX; pfam02687 935697005869 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 935697005870 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 935697005871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 935697005872 Histidine kinase; Region: HisKA_3; pfam07730 935697005873 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 935697005874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935697005875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935697005876 active site 935697005877 phosphorylation site [posttranslational modification] 935697005878 intermolecular recognition site; other site 935697005879 dimerization interface [polypeptide binding]; other site 935697005880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935697005881 DNA binding residues [nucleotide binding] 935697005882 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 935697005883 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 935697005884 active site 935697005885 trimer interface [polypeptide binding]; other site 935697005886 allosteric site; other site 935697005887 active site lid [active] 935697005888 hexamer (dimer of trimers) interface [polypeptide binding]; other site 935697005889 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 935697005890 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 935697005891 active site 935697005892 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 935697005893 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 935697005894 putative active site cavity [active] 935697005895 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 935697005896 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 935697005897 nucleotide binding site [chemical binding]; other site 935697005898 Transcriptional regulators [Transcription]; Region: FadR; COG2186 935697005899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935697005900 DNA-binding site [nucleotide binding]; DNA binding site 935697005901 FCD domain; Region: FCD; pfam07729 935697005902 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 935697005903 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 935697005904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 935697005905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697005906 dimer interface [polypeptide binding]; other site 935697005907 conserved gate region; other site 935697005908 putative PBP binding loops; other site 935697005909 ABC-ATPase subunit interface; other site 935697005910 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 935697005911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935697005912 dimer interface [polypeptide binding]; other site 935697005913 conserved gate region; other site 935697005914 putative PBP binding loops; other site 935697005915 ABC-ATPase subunit interface; other site 935697005916 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 935697005917 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697005918 Walker A/P-loop; other site 935697005919 ATP binding site [chemical binding]; other site 935697005920 Q-loop/lid; other site 935697005921 ABC transporter signature motif; other site 935697005922 Walker B; other site 935697005923 D-loop; other site 935697005924 H-loop/switch region; other site 935697005925 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 935697005926 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 935697005927 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 935697005928 Walker A/P-loop; other site 935697005929 ATP binding site [chemical binding]; other site 935697005930 Q-loop/lid; other site 935697005931 ABC transporter signature motif; other site 935697005932 Walker B; other site 935697005933 D-loop; other site 935697005934 H-loop/switch region; other site 935697005935 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 935697005936 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 935697005937 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 935697005938 inhibitor site; inhibition site 935697005939 active site 935697005940 dimer interface [polypeptide binding]; other site 935697005941 catalytic residue [active] 935697005942 CAAX protease self-immunity; Region: Abi; pfam02517 935697005943 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 935697005944 active site 935697005945 catalytic residues [active] 935697005946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 935697005947 hypothetical protein; Provisional; Region: PRK13663 935697005948 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 935697005949 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 935697005950 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 935697005951 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 935697005952 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 935697005953 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 935697005954 substrate binding pocket [chemical binding]; other site 935697005955 substrate-Mg2+ binding site; other site 935697005956 aspartate-rich region 1; other site 935697005957 aspartate-rich region 2; other site 935697005958 phytoene desaturase; Region: crtI_fam; TIGR02734 935697005959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935697005960 SdpI/YhfL protein family; Region: SdpI; pfam13630 935697005961 anthranilate synthase component I; Provisional; Region: PRK13564 935697005962 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 935697005963 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 935697005964 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 935697005965 Glutamine amidotransferase class-I; Region: GATase; pfam00117 935697005966 glutamine binding [chemical binding]; other site 935697005967 catalytic triad [active] 935697005968 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 935697005969 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 935697005970 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 935697005971 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 935697005972 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 935697005973 active site 935697005974 ribulose/triose binding site [chemical binding]; other site 935697005975 phosphate binding site [ion binding]; other site 935697005976 substrate (anthranilate) binding pocket [chemical binding]; other site 935697005977 product (indole) binding pocket [chemical binding]; other site 935697005978 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 935697005979 active site 935697005980 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 935697005981 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 935697005982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935697005983 catalytic residue [active] 935697005984 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 935697005985 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 935697005986 substrate binding site [chemical binding]; other site 935697005987 active site 935697005988 catalytic residues [active] 935697005989 heterodimer interface [polypeptide binding]; other site 935697005990 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 935697005991 iron-sulfur cluster [ion binding]; other site 935697005992 [2Fe-2S] cluster binding site [ion binding]; other site 935697005993 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 935697005994 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 935697005995 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 935697005996 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 935697005997 hypothetical protein; Validated; Region: PRK00228 935697005998 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 935697005999 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935697006000 active site 935697006001 NTP binding site [chemical binding]; other site 935697006002 metal binding triad [ion binding]; metal-binding site 935697006003 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935697006004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935697006005 Zn2+ binding site [ion binding]; other site 935697006006 Mg2+ binding site [ion binding]; other site 935697006007 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 935697006008 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 935697006009 active site 935697006010 Ap6A binding site [chemical binding]; other site 935697006011 nudix motif; other site 935697006012 metal binding site [ion binding]; metal-binding site 935697006013 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 935697006014 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 935697006015 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 935697006016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935697006017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935697006018 DNA binding residues [nucleotide binding] 935697006019 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 935697006020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935697006021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935697006022 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 935697006023 catalytic residues [active] 935697006024 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 935697006025 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 935697006026 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 935697006027 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935697006028 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935697006029 active site 935697006030 metal binding site [ion binding]; metal-binding site 935697006031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 935697006032 ParB-like nuclease domain; Region: ParBc; pfam02195 935697006033 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 935697006034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935697006035 P-loop; other site 935697006036 Magnesium ion binding site [ion binding]; other site 935697006037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935697006038 Magnesium ion binding site [ion binding]; other site 935697006039 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 935697006040 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 935697006041 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 935697006042 Haemolytic domain; Region: Haemolytic; pfam01809 935697006043 ribonuclease P; Reviewed; Region: rnpA; PRK03459 935697006044 Ribosomal protein L34; Region: Ribosomal_L34; cl00370