-- dump date 20140619_052609 -- class Genbank::misc_feature -- table misc_feature_note -- id note 765874000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 765874000003 Walker A motif; other site 765874000004 ATP binding site [chemical binding]; other site 765874000005 Walker B motif; other site 765874000006 arginine finger; other site 765874000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 765874000008 DnaA box-binding interface [nucleotide binding]; other site 765874000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 765874000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 765874000011 putative DNA binding surface [nucleotide binding]; other site 765874000012 dimer interface [polypeptide binding]; other site 765874000013 beta-clamp/clamp loader binding surface; other site 765874000014 beta-clamp/translesion DNA polymerase binding surface; other site 765874000015 recombination protein F; Reviewed; Region: recF; PRK00064 765874000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 765874000017 Walker A/P-loop; other site 765874000018 ATP binding site [chemical binding]; other site 765874000019 Q-loop/lid; other site 765874000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874000021 ABC transporter signature motif; other site 765874000022 Walker B; other site 765874000023 D-loop; other site 765874000024 H-loop/switch region; other site 765874000025 hypothetical protein; Provisional; Region: PRK00111 765874000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 765874000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874000028 ATP binding site [chemical binding]; other site 765874000029 Mg2+ binding site [ion binding]; other site 765874000030 G-X-G motif; other site 765874000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 765874000032 anchoring element; other site 765874000033 dimer interface [polypeptide binding]; other site 765874000034 ATP binding site [chemical binding]; other site 765874000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 765874000036 active site 765874000037 putative metal-binding site [ion binding]; other site 765874000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 765874000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 765874000040 metal binding site [ion binding]; metal-binding site 765874000041 DNA gyrase subunit A; Validated; Region: PRK05560 765874000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 765874000043 CAP-like domain; other site 765874000044 active site 765874000045 primary dimer interface [polypeptide binding]; other site 765874000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765874000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765874000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765874000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765874000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765874000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765874000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 765874000053 YwiC-like protein; Region: YwiC; pfam14256 765874000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 765874000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 765874000056 putative ligand binding site [chemical binding]; other site 765874000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 765874000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 765874000059 TM-ABC transporter signature motif; other site 765874000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 765874000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 765874000062 Walker A/P-loop; other site 765874000063 ATP binding site [chemical binding]; other site 765874000064 Q-loop/lid; other site 765874000065 ABC transporter signature motif; other site 765874000066 Walker B; other site 765874000067 D-loop; other site 765874000068 H-loop/switch region; other site 765874000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 765874000070 active site 765874000071 Rhomboid family; Region: Rhomboid; pfam01694 765874000072 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 765874000073 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 765874000074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 765874000075 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 765874000076 putative active site [active] 765874000077 catalytic site [active] 765874000078 Mg binding site [ion binding]; other site 765874000079 catalytic loop [active] 765874000080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874000081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874000082 Walker A/P-loop; other site 765874000083 ATP binding site [chemical binding]; other site 765874000084 Q-loop/lid; other site 765874000085 ABC transporter signature motif; other site 765874000086 Walker B; other site 765874000087 D-loop; other site 765874000088 H-loop/switch region; other site 765874000089 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 765874000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874000091 ABC-ATPase subunit interface; other site 765874000092 dimer interface [polypeptide binding]; other site 765874000093 putative PBP binding regions; other site 765874000094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874000095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874000096 ABC-ATPase subunit interface; other site 765874000097 dimer interface [polypeptide binding]; other site 765874000098 putative PBP binding regions; other site 765874000099 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 765874000100 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 765874000101 siderophore binding site; other site 765874000102 putative septation inhibitor protein; Reviewed; Region: PRK00159 765874000103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765874000104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765874000105 active site 765874000106 ATP binding site [chemical binding]; other site 765874000107 substrate binding site [chemical binding]; other site 765874000108 activation loop (A-loop); other site 765874000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 765874000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874000111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874000112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874000113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874000114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765874000115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765874000116 active site 765874000117 ATP binding site [chemical binding]; other site 765874000118 substrate binding site [chemical binding]; other site 765874000119 activation loop (A-loop); other site 765874000120 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 765874000121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 765874000122 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 765874000123 Protein phosphatase 2C; Region: PP2C; pfam00481 765874000124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 765874000125 active site 765874000126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765874000127 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 765874000128 phosphopeptide binding site; other site 765874000129 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 765874000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765874000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 765874000132 phosphopeptide binding site; other site 765874000133 CAAX protease self-immunity; Region: Abi; pfam02517 765874000134 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 765874000135 Predicted transcriptional regulators [Transcription]; Region: COG1695 765874000136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 765874000137 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 765874000138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874000139 intersubunit interface [polypeptide binding]; other site 765874000140 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874000141 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874000142 Walker A/P-loop; other site 765874000143 ATP binding site [chemical binding]; other site 765874000144 Q-loop/lid; other site 765874000145 ABC transporter signature motif; other site 765874000146 Walker B; other site 765874000147 D-loop; other site 765874000148 H-loop/switch region; other site 765874000149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874000150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874000151 ABC-ATPase subunit interface; other site 765874000152 dimer interface [polypeptide binding]; other site 765874000153 putative PBP binding regions; other site 765874000154 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765874000155 MgtE intracellular N domain; Region: MgtE_N; smart00924 765874000156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765874000157 Divalent cation transporter; Region: MgtE; pfam01769 765874000158 trehalose synthase; Region: treS_nterm; TIGR02456 765874000159 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 765874000160 active site 765874000161 catalytic site [active] 765874000162 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 765874000163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874000164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874000165 putative substrate translocation pore; other site 765874000166 Anti-sigma-K factor rskA; Region: RskA; pfam10099 765874000167 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 765874000168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874000169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874000170 DNA binding residues [nucleotide binding] 765874000171 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 765874000172 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 765874000173 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 765874000174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765874000175 catalytic residues [active] 765874000176 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 765874000177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874000178 dimer interface [polypeptide binding]; other site 765874000179 conserved gate region; other site 765874000180 putative PBP binding loops; other site 765874000181 ABC-ATPase subunit interface; other site 765874000182 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 765874000183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874000184 Walker A/P-loop; other site 765874000185 ATP binding site [chemical binding]; other site 765874000186 Q-loop/lid; other site 765874000187 ABC transporter signature motif; other site 765874000188 Walker B; other site 765874000189 D-loop; other site 765874000190 H-loop/switch region; other site 765874000191 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 765874000192 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 765874000193 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 765874000194 putative metal binding site [ion binding]; other site 765874000195 biotin synthase; Validated; Region: PRK06256 765874000196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874000197 FeS/SAM binding site; other site 765874000198 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 765874000199 MepB protein; Region: MepB; cl01985 765874000200 AMP nucleosidase; Provisional; Region: PRK08292 765874000201 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 765874000202 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 765874000203 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 765874000204 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 765874000205 active site 765874000206 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 765874000207 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 765874000208 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 765874000209 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 765874000210 Lipase (class 2); Region: Lipase_2; pfam01674 765874000211 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 765874000212 dimer interface [polypeptide binding]; other site 765874000213 FMN binding site [chemical binding]; other site 765874000214 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 765874000215 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 765874000216 trimer interface [polypeptide binding]; other site 765874000217 putative metal binding site [ion binding]; other site 765874000218 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 765874000219 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 765874000220 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 765874000221 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 765874000222 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765874000223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874000224 Coenzyme A binding pocket [chemical binding]; other site 765874000225 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 765874000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 765874000227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 765874000228 MarR family; Region: MarR; pfam01047 765874000229 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 765874000230 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 765874000231 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 765874000232 hypothetical protein; Provisional; Region: PRK10621 765874000233 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 765874000234 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765874000235 active site 765874000236 phosphorylation site [posttranslational modification] 765874000237 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 765874000238 active site 765874000239 P-loop; other site 765874000240 phosphorylation site [posttranslational modification] 765874000241 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 765874000242 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 765874000243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874000244 ATP binding site [chemical binding]; other site 765874000245 putative Mg++ binding site [ion binding]; other site 765874000246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874000247 nucleotide binding region [chemical binding]; other site 765874000248 ATP-binding site [chemical binding]; other site 765874000249 Helicase associated domain (HA2); Region: HA2; pfam04408 765874000250 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 765874000251 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 765874000252 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 765874000253 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 765874000254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874000255 NAD(P) binding site [chemical binding]; other site 765874000256 active site 765874000257 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 765874000258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765874000259 RNA binding surface [nucleotide binding]; other site 765874000260 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 765874000261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765874000262 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 765874000263 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765874000264 DNA binding site [nucleotide binding] 765874000265 active site 765874000266 Domain of unknown function (DUF222); Region: DUF222; pfam02720 765874000267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 765874000268 active site 765874000269 glycerol kinase; Provisional; Region: glpK; PRK00047 765874000270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 765874000271 nucleotide binding site [chemical binding]; other site 765874000272 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 765874000273 amphipathic channel; other site 765874000274 Asn-Pro-Ala signature motifs; other site 765874000275 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 765874000276 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 765874000277 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 765874000278 active site 765874000279 Zn binding site [ion binding]; other site 765874000280 Protease prsW family; Region: PrsW-protease; pfam13367 765874000281 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 765874000282 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 765874000283 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 765874000284 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 765874000285 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 765874000286 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 765874000287 classical (c) SDRs; Region: SDR_c; cd05233 765874000288 NAD(P) binding site [chemical binding]; other site 765874000289 active site 765874000290 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 765874000291 FAD binding domain; Region: FAD_binding_4; pfam01565 765874000292 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 765874000293 Predicted membrane protein [Function unknown]; Region: COG2246 765874000294 GtrA-like protein; Region: GtrA; pfam04138 765874000295 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 765874000296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765874000297 active site 765874000298 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874000299 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765874000300 intersubunit interface [polypeptide binding]; other site 765874000301 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 765874000302 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 765874000303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765874000304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765874000305 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765874000306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874000307 ABC-ATPase subunit interface; other site 765874000308 dimer interface [polypeptide binding]; other site 765874000309 putative PBP binding regions; other site 765874000310 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874000311 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765874000312 intersubunit interface [polypeptide binding]; other site 765874000313 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 765874000314 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 765874000315 active site 765874000316 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 765874000317 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 765874000318 Walker A/P-loop; other site 765874000319 ATP binding site [chemical binding]; other site 765874000320 Q-loop/lid; other site 765874000321 ABC transporter signature motif; other site 765874000322 Walker B; other site 765874000323 D-loop; other site 765874000324 H-loop/switch region; other site 765874000325 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 765874000326 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 765874000327 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 765874000328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765874000329 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 765874000330 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 765874000331 NAD(P) binding site [chemical binding]; other site 765874000332 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 765874000333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874000334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874000335 homodimer interface [polypeptide binding]; other site 765874000336 catalytic residue [active] 765874000337 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 765874000338 transmembrane helices; other site 765874000339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 765874000340 CAT RNA binding domain; Region: CAT_RBD; smart01061 765874000341 PRD domain; Region: PRD; pfam00874 765874000342 PRD domain; Region: PRD; pfam00874 765874000343 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 765874000344 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 765874000345 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 765874000346 active site turn [active] 765874000347 phosphorylation site [posttranslational modification] 765874000348 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 765874000349 HPr interaction site; other site 765874000350 glycerol kinase (GK) interaction site [polypeptide binding]; other site 765874000351 active site 765874000352 phosphorylation site [posttranslational modification] 765874000353 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 765874000354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765874000355 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 765874000356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765874000357 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 765874000358 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 765874000359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874000360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874000361 homodimer interface [polypeptide binding]; other site 765874000362 catalytic residue [active] 765874000363 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 765874000364 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 765874000365 active site 765874000366 multimer interface [polypeptide binding]; other site 765874000367 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 765874000368 predicted active site [active] 765874000369 catalytic triad [active] 765874000370 prephenate dehydrogenase; Validated; Region: PRK06545 765874000371 prephenate dehydrogenase; Validated; Region: PRK08507 765874000372 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 765874000373 nucleoside/Zn binding site; other site 765874000374 dimer interface [polypeptide binding]; other site 765874000375 catalytic motif [active] 765874000376 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 765874000377 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 765874000378 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 765874000379 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 765874000380 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 765874000381 active site 765874000382 HIGH motif; other site 765874000383 nucleotide binding site [chemical binding]; other site 765874000384 active site 765874000385 KMSKS motif; other site 765874000386 fructuronate transporter; Provisional; Region: PRK10034; cl15264 765874000387 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 765874000388 Shikimate kinase; Region: SKI; pfam01202 765874000389 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 765874000390 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 765874000391 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 765874000392 putative NAD(P) binding site [chemical binding]; other site 765874000393 catalytic Zn binding site [ion binding]; other site 765874000394 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 765874000395 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 765874000396 NADP binding site [chemical binding]; other site 765874000397 homodimer interface [polypeptide binding]; other site 765874000398 active site 765874000399 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 765874000400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874000401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874000402 homodimer interface [polypeptide binding]; other site 765874000403 catalytic residue [active] 765874000404 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 765874000405 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 765874000406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874000407 Walker A motif; other site 765874000408 ATP binding site [chemical binding]; other site 765874000409 Walker B motif; other site 765874000410 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765874000411 arginine finger; other site 765874000412 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 765874000413 hypothetical protein; Validated; Region: PRK00153 765874000414 recombination protein RecR; Reviewed; Region: recR; PRK00076 765874000415 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 765874000416 RecR protein; Region: RecR; pfam02132 765874000417 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 765874000418 putative active site [active] 765874000419 putative metal-binding site [ion binding]; other site 765874000420 tetramer interface [polypeptide binding]; other site 765874000421 putative transporter; Provisional; Region: PRK09821 765874000422 GntP family permease; Region: GntP_permease; pfam02447 765874000423 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 765874000424 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 765874000425 Protein of unknown function, DUF1537; Region: DUF1537; pfam07005 765874000426 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 765874000427 Transcriptional regulators [Transcription]; Region: FadR; COG2186 765874000428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 765874000429 DNA-binding site [nucleotide binding]; DNA binding site 765874000430 FCD domain; Region: FCD; pfam07729 765874000431 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 765874000432 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 765874000433 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 765874000434 catalytic triad [active] 765874000435 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 765874000436 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874000437 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 765874000438 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 765874000439 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765874000440 active site 765874000441 catalytic site [active] 765874000442 substrate binding site [chemical binding]; other site 765874000443 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 765874000444 potential frameshift: common BLAST hit: gi|38232888|ref|NP_938655.1| nitroreductase 765874000445 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 765874000446 FMN binding site [chemical binding]; other site 765874000447 NADPH bind site [chemical binding]; other site 765874000448 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 765874000449 FMN binding site [chemical binding]; other site 765874000450 2-isopropylmalate synthase; Validated; Region: PRK03739 765874000451 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 765874000452 active site 765874000453 catalytic residues [active] 765874000454 metal binding site [ion binding]; metal-binding site 765874000455 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 765874000456 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 765874000457 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874000458 DNA binding residues [nucleotide binding] 765874000459 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 765874000460 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 765874000461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874000462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874000463 putative substrate translocation pore; other site 765874000464 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 765874000465 intersubunit interface [polypeptide binding]; other site 765874000466 active site 765874000467 catalytic residue [active] 765874000468 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 765874000469 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 765874000470 active site 765874000471 substrate binding site [chemical binding]; other site 765874000472 metal binding site [ion binding]; metal-binding site 765874000473 TQXA domain; Region: TQXA_dom; TIGR03934 765874000474 Cna protein B-type domain; Region: Cna_B; pfam05738 765874000475 Cna protein B-type domain; Region: Cna_B; pfam05738 765874000476 Cna protein B-type domain; Region: Cna_B; pfam05738 765874000477 aspartate kinase; Reviewed; Region: PRK06635 765874000478 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 765874000479 putative nucleotide binding site [chemical binding]; other site 765874000480 putative catalytic residues [active] 765874000481 putative Mg ion binding site [ion binding]; other site 765874000482 putative aspartate binding site [chemical binding]; other site 765874000483 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 765874000484 putative allosteric regulatory site; other site 765874000485 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 765874000486 putative allosteric regulatory residue; other site 765874000487 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 765874000488 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 765874000489 RNA polymerase sigma factor; Provisional; Region: PRK12535 765874000490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874000491 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 765874000492 DNA binding residues [nucleotide binding] 765874000493 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 765874000494 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 765874000495 heme binding pocket [chemical binding]; other site 765874000496 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 765874000497 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 765874000498 Walker A/P-loop; other site 765874000499 ATP binding site [chemical binding]; other site 765874000500 Q-loop/lid; other site 765874000501 ABC transporter signature motif; other site 765874000502 Walker B; other site 765874000503 D-loop; other site 765874000504 H-loop/switch region; other site 765874000505 TOBE domain; Region: TOBE_2; pfam08402 765874000506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874000507 dimer interface [polypeptide binding]; other site 765874000508 conserved gate region; other site 765874000509 ABC-ATPase subunit interface; other site 765874000510 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 765874000511 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 765874000512 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 765874000513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874000514 putative substrate translocation pore; other site 765874000515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765874000516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874000517 active site 765874000518 phosphorylation site [posttranslational modification] 765874000519 intermolecular recognition site; other site 765874000520 dimerization interface [polypeptide binding]; other site 765874000521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765874000522 DNA binding site [nucleotide binding] 765874000523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 765874000524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765874000525 dimer interface [polypeptide binding]; other site 765874000526 phosphorylation site [posttranslational modification] 765874000527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874000528 ATP binding site [chemical binding]; other site 765874000529 Mg2+ binding site [ion binding]; other site 765874000530 G-X-G motif; other site 765874000531 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 765874000532 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 765874000533 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 765874000534 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 765874000535 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765874000536 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 765874000537 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 765874000538 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765874000539 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 765874000540 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 765874000541 Predicted membrane protein [Function unknown]; Region: COG1511 765874000542 Predicted membrane protein [Function unknown]; Region: COG1511 765874000543 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 765874000544 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 765874000545 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 765874000546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874000547 Walker A/P-loop; other site 765874000548 ATP binding site [chemical binding]; other site 765874000549 Q-loop/lid; other site 765874000550 ABC transporter signature motif; other site 765874000551 Walker B; other site 765874000552 D-loop; other site 765874000553 H-loop/switch region; other site 765874000554 potential frameshift: common BLAST hit: gi|172041606|ref|YP_001801320.1| transposase for insertion sequence 765874000555 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765874000556 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765874000557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 765874000558 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 765874000559 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765874000560 putative active site [active] 765874000561 putative metal binding site [ion binding]; other site 765874000562 Yqey-like protein; Region: YqeY; pfam09424 765874000563 Transglycosylase; Region: Transgly; pfam00912 765874000564 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 765874000565 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 765874000566 PASTA domain; Region: PASTA; pfam03793 765874000567 Transcription factor WhiB; Region: Whib; pfam02467 765874000568 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 765874000569 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 765874000570 homotrimer interaction site [polypeptide binding]; other site 765874000571 putative active site [active] 765874000572 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 765874000573 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 765874000574 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 765874000575 ligand binding site [chemical binding]; other site 765874000576 flexible hinge region; other site 765874000577 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 765874000578 putative switch regulator; other site 765874000579 non-specific DNA interactions [nucleotide binding]; other site 765874000580 DNA binding site [nucleotide binding] 765874000581 sequence specific DNA binding site [nucleotide binding]; other site 765874000582 putative cAMP binding site [chemical binding]; other site 765874000583 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 765874000584 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765874000585 minor groove reading motif; other site 765874000586 helix-hairpin-helix signature motif; other site 765874000587 substrate binding pocket [chemical binding]; other site 765874000588 active site 765874000589 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 765874000590 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 765874000591 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765874000592 catalytic residues [active] 765874000593 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 765874000594 putative active site [active] 765874000595 putative CoA binding site [chemical binding]; other site 765874000596 nudix motif; other site 765874000597 metal binding site [ion binding]; metal-binding site 765874000598 Colicin V production protein; Region: Colicin_V; pfam02674 765874000599 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 765874000600 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 765874000601 active site 765874000602 substrate binding sites [chemical binding]; other site 765874000603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 765874000604 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 765874000605 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 765874000606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874000607 motif II; other site 765874000608 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 765874000609 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 765874000610 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 765874000611 ATP binding site [chemical binding]; other site 765874000612 Walker A motif; other site 765874000613 hexamer interface [polypeptide binding]; other site 765874000614 Walker B motif; other site 765874000615 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 765874000616 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 765874000617 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 765874000618 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 765874000619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874000620 ATP binding site [chemical binding]; other site 765874000621 putative Mg++ binding site [ion binding]; other site 765874000622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874000623 nucleotide binding region [chemical binding]; other site 765874000624 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 765874000625 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 765874000626 DNA-binding site [nucleotide binding]; DNA binding site 765874000627 RNA-binding motif; other site 765874000628 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 765874000629 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 765874000630 active site 765874000631 interdomain interaction site; other site 765874000632 putative metal-binding site [ion binding]; other site 765874000633 nucleotide binding site [chemical binding]; other site 765874000634 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 765874000635 domain I; other site 765874000636 DNA binding groove [nucleotide binding] 765874000637 phosphate binding site [ion binding]; other site 765874000638 domain II; other site 765874000639 domain III; other site 765874000640 nucleotide binding site [chemical binding]; other site 765874000641 catalytic site [active] 765874000642 domain IV; other site 765874000643 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 765874000644 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 765874000645 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 765874000646 Predicted membrane protein [Function unknown]; Region: COG1297 765874000647 putative oligopeptide transporter, OPT family; Region: TIGR00733 765874000648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765874000649 dimerization interface [polypeptide binding]; other site 765874000650 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 765874000651 cyclase homology domain; Region: CHD; cd07302 765874000652 nucleotidyl binding site; other site 765874000653 metal binding site [ion binding]; metal-binding site 765874000654 dimer interface [polypeptide binding]; other site 765874000655 DNA polymerase III subunit delta'; Validated; Region: PRK07940 765874000656 DNA polymerase III subunit delta'; Validated; Region: PRK08485 765874000657 acyl-CoA synthetase; Validated; Region: PRK07788 765874000658 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874000659 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874000660 acyl-activating enzyme (AAE) consensus motif; other site 765874000661 acyl-activating enzyme (AAE) consensus motif; other site 765874000662 AMP binding site [chemical binding]; other site 765874000663 active site 765874000664 CoA binding site [chemical binding]; other site 765874000665 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 765874000666 active site 765874000667 catalytic triad [active] 765874000668 oxyanion hole [active] 765874000669 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 765874000670 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 765874000671 substrate binding site; other site 765874000672 tetramer interface; other site 765874000673 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 765874000674 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 765874000675 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 765874000676 NADP binding site [chemical binding]; other site 765874000677 active site 765874000678 putative substrate binding site [chemical binding]; other site 765874000679 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 765874000680 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 765874000681 NAD binding site [chemical binding]; other site 765874000682 substrate binding site [chemical binding]; other site 765874000683 homodimer interface [polypeptide binding]; other site 765874000684 active site 765874000685 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 765874000686 Zn binding site [ion binding]; other site 765874000687 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 765874000688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 765874000689 Putative esterase; Region: Esterase; pfam00756 765874000690 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 765874000691 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 765874000692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765874000693 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765874000694 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 765874000695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765874000696 non-specific DNA binding site [nucleotide binding]; other site 765874000697 salt bridge; other site 765874000698 sequence-specific DNA binding site [nucleotide binding]; other site 765874000699 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 765874000700 Domain of unknown function (DUF955); Region: DUF955; pfam06114 765874000701 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 765874000702 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 765874000703 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 765874000704 putative Iron-sulfur protein interface [polypeptide binding]; other site 765874000705 proximal heme binding site [chemical binding]; other site 765874000706 distal heme binding site [chemical binding]; other site 765874000707 putative dimer interface [polypeptide binding]; other site 765874000708 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 765874000709 L-aspartate oxidase; Provisional; Region: PRK06175 765874000710 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 765874000711 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 765874000712 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 765874000713 Predicted membrane protein [Function unknown]; Region: COG2733 765874000714 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 765874000715 Class I aldolases; Region: Aldolase_Class_I; cl17187 765874000716 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 765874000717 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 765874000718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874000719 FeS/SAM binding site; other site 765874000720 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 765874000721 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 765874000722 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 765874000723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 765874000724 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 765874000725 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 765874000726 FAD binding domain; Region: FAD_binding_4; pfam01565 765874000727 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 765874000728 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 765874000729 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 765874000730 acyl-activating enzyme (AAE) consensus motif; other site 765874000731 putative AMP binding site [chemical binding]; other site 765874000732 putative active site [active] 765874000733 putative CoA binding site [chemical binding]; other site 765874000734 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 765874000735 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 765874000736 putative ADP-binding pocket [chemical binding]; other site 765874000737 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874000738 catalytic core [active] 765874000739 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874000740 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 765874000741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765874000742 dimer interface [polypeptide binding]; other site 765874000743 phosphorylation site [posttranslational modification] 765874000744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874000745 ATP binding site [chemical binding]; other site 765874000746 Mg2+ binding site [ion binding]; other site 765874000747 G-X-G motif; other site 765874000748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765874000749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874000750 active site 765874000751 phosphorylation site [posttranslational modification] 765874000752 intermolecular recognition site; other site 765874000753 dimerization interface [polypeptide binding]; other site 765874000754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765874000755 DNA binding site [nucleotide binding] 765874000756 exopolyphosphatase; Region: exo_poly_only; TIGR03706 765874000757 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 765874000758 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 765874000759 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 765874000760 DNA binding domain, excisionase family; Region: excise; TIGR01764 765874000761 Thioredoxin; Region: Thioredoxin_4; cl17273 765874000762 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 765874000763 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 765874000764 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 765874000765 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 765874000766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874000767 motif II; other site 765874000768 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 765874000769 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 765874000770 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 765874000771 tRNA; other site 765874000772 putative tRNA binding site [nucleotide binding]; other site 765874000773 putative NADP binding site [chemical binding]; other site 765874000774 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 765874000775 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 765874000776 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 765874000777 domain interfaces; other site 765874000778 active site 765874000779 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 765874000780 active site 765874000781 homodimer interface [polypeptide binding]; other site 765874000782 SAM binding site [chemical binding]; other site 765874000783 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 765874000784 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 765874000785 active site 765874000786 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 765874000787 dimer interface [polypeptide binding]; other site 765874000788 active site 765874000789 Schiff base residues; other site 765874000790 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765874000791 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 765874000792 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 765874000793 substrate binding site [chemical binding]; other site 765874000794 active site 765874000795 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 765874000796 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 765874000797 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 765874000798 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 765874000799 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765874000800 inhibitor-cofactor binding pocket; inhibition site 765874000801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874000802 catalytic residue [active] 765874000803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874000804 catalytic core [active] 765874000805 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 765874000806 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765874000807 catalytic residues [active] 765874000808 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 765874000809 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 765874000810 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 765874000811 ResB-like family; Region: ResB; pfam05140 765874000812 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765874000813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874000814 S-adenosylmethionine binding site [chemical binding]; other site 765874000815 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874000816 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874000817 Walker A/P-loop; other site 765874000818 ATP binding site [chemical binding]; other site 765874000819 Q-loop/lid; other site 765874000820 ABC transporter signature motif; other site 765874000821 Walker B; other site 765874000822 D-loop; other site 765874000823 H-loop/switch region; other site 765874000824 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 765874000825 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874000826 intersubunit interface [polypeptide binding]; other site 765874000827 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 765874000828 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874000829 ABC-ATPase subunit interface; other site 765874000830 dimer interface [polypeptide binding]; other site 765874000831 putative PBP binding regions; other site 765874000832 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 765874000833 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 765874000834 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 765874000835 UbiA prenyltransferase family; Region: UbiA; pfam01040 765874000836 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 765874000837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874000838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874000839 acyl-activating enzyme (AAE) consensus motif; other site 765874000840 acyl-activating enzyme (AAE) consensus motif; other site 765874000841 AMP binding site [chemical binding]; other site 765874000842 active site 765874000843 CoA binding site [chemical binding]; other site 765874000844 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 765874000845 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765874000846 substrate binding site [chemical binding]; other site 765874000847 oxyanion hole (OAH) forming residues; other site 765874000848 trimer interface [polypeptide binding]; other site 765874000849 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 765874000850 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 765874000851 O-succinylbenzoate synthase; Provisional; Region: PRK02901 765874000852 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 765874000853 active site 765874000854 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 765874000855 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 765874000856 dimer interface [polypeptide binding]; other site 765874000857 tetramer interface [polypeptide binding]; other site 765874000858 PYR/PP interface [polypeptide binding]; other site 765874000859 TPP binding site [chemical binding]; other site 765874000860 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 765874000861 TPP-binding site; other site 765874000862 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 765874000863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765874000864 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 765874000865 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 765874000866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874000867 S-adenosylmethionine binding site [chemical binding]; other site 765874000868 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 765874000869 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 765874000870 NAD(P) binding site [chemical binding]; other site 765874000871 LDH/MDH dimer interface [polypeptide binding]; other site 765874000872 substrate binding site [chemical binding]; other site 765874000873 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 765874000874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765874000875 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 765874000876 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765874000877 substrate binding pocket [chemical binding]; other site 765874000878 chain length determination region; other site 765874000879 substrate-Mg2+ binding site; other site 765874000880 catalytic residues [active] 765874000881 aspartate-rich region 1; other site 765874000882 active site lid residues [active] 765874000883 aspartate-rich region 2; other site 765874000884 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 765874000885 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 765874000886 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 765874000887 putative homodimer interface [polypeptide binding]; other site 765874000888 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 765874000889 heterodimer interface [polypeptide binding]; other site 765874000890 homodimer interface [polypeptide binding]; other site 765874000891 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 765874000892 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 765874000893 23S rRNA interface [nucleotide binding]; other site 765874000894 L7/L12 interface [polypeptide binding]; other site 765874000895 putative thiostrepton binding site; other site 765874000896 L25 interface [polypeptide binding]; other site 765874000897 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 765874000898 mRNA/rRNA interface [nucleotide binding]; other site 765874000899 potential frameshift: common BLAST hit: gi|237785133|ref|YP_002905838.1| aminopeptidase C 765874000900 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 765874000901 active site 765874000902 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 765874000903 trimer interface [polypeptide binding]; other site 765874000904 active site 765874000905 G bulge; other site 765874000906 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 765874000907 trimer interface [polypeptide binding]; other site 765874000908 active site 765874000909 G bulge; other site 765874000910 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 765874000911 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 765874000912 FMN binding site [chemical binding]; other site 765874000913 active site 765874000914 substrate binding site [chemical binding]; other site 765874000915 catalytic residue [active] 765874000916 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 765874000917 23S rRNA interface [nucleotide binding]; other site 765874000918 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 765874000919 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 765874000920 L11 interface [polypeptide binding]; other site 765874000921 putative EF-Tu interaction site [polypeptide binding]; other site 765874000922 putative EF-G interaction site [polypeptide binding]; other site 765874000923 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874000924 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 765874000925 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874000926 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874000927 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874000928 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874000929 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 765874000930 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 765874000931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765874000932 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765874000933 ABC-ATPase subunit interface; other site 765874000934 dimer interface [polypeptide binding]; other site 765874000935 putative PBP binding regions; other site 765874000936 Ethylene insensitive 3; Region: EIN3; cl04813 765874000937 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 765874000938 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 765874000939 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 765874000940 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 765874000941 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765874000942 RPB1 interaction site [polypeptide binding]; other site 765874000943 RPB10 interaction site [polypeptide binding]; other site 765874000944 RPB11 interaction site [polypeptide binding]; other site 765874000945 RPB3 interaction site [polypeptide binding]; other site 765874000946 RPB12 interaction site [polypeptide binding]; other site 765874000947 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 765874000948 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 765874000949 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 765874000950 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 765874000951 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 765874000952 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 765874000953 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 765874000954 G-loop; other site 765874000955 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 765874000956 DNA binding site [nucleotide binding] 765874000957 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 765874000958 Histidine kinase; Region: HisKA_3; pfam07730 765874000959 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 765874000960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765874000961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874000962 active site 765874000963 phosphorylation site [posttranslational modification] 765874000964 intermolecular recognition site; other site 765874000965 dimerization interface [polypeptide binding]; other site 765874000966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765874000967 DNA binding residues [nucleotide binding] 765874000968 dimerization interface [polypeptide binding]; other site 765874000969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765874000970 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 765874000971 Walker A/P-loop; other site 765874000972 ATP binding site [chemical binding]; other site 765874000973 Q-loop/lid; other site 765874000974 ABC transporter signature motif; other site 765874000975 Walker B; other site 765874000976 D-loop; other site 765874000977 H-loop/switch region; other site 765874000978 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 765874000979 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 765874000980 TIGR03943 family protein; Region: TIGR03943 765874000981 Predicted permease; Region: DUF318; cl17795 765874000982 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 765874000983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874000984 FeS/SAM binding site; other site 765874000985 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 765874000986 Class III ribonucleotide reductase; Region: RNR_III; cd01675 765874000987 effector binding site; other site 765874000988 active site 765874000989 Zn binding site [ion binding]; other site 765874000990 glycine loop; other site 765874000991 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 765874000992 S17 interaction site [polypeptide binding]; other site 765874000993 S8 interaction site; other site 765874000994 16S rRNA interaction site [nucleotide binding]; other site 765874000995 streptomycin interaction site [chemical binding]; other site 765874000996 23S rRNA interaction site [nucleotide binding]; other site 765874000997 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 765874000998 30S ribosomal protein S7; Validated; Region: PRK05302 765874000999 elongation factor G; Reviewed; Region: PRK00007 765874001000 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 765874001001 G1 box; other site 765874001002 putative GEF interaction site [polypeptide binding]; other site 765874001003 GTP/Mg2+ binding site [chemical binding]; other site 765874001004 Switch I region; other site 765874001005 G2 box; other site 765874001006 G3 box; other site 765874001007 Switch II region; other site 765874001008 G4 box; other site 765874001009 G5 box; other site 765874001010 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 765874001011 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 765874001012 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 765874001013 elongation factor Tu; Reviewed; Region: PRK00049 765874001014 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 765874001015 G1 box; other site 765874001016 GEF interaction site [polypeptide binding]; other site 765874001017 GTP/Mg2+ binding site [chemical binding]; other site 765874001018 Switch I region; other site 765874001019 G2 box; other site 765874001020 G3 box; other site 765874001021 Switch II region; other site 765874001022 G4 box; other site 765874001023 G5 box; other site 765874001024 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 765874001025 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 765874001026 Antibiotic Binding Site [chemical binding]; other site 765874001027 Asp23 family; Region: Asp23; cl00574 765874001028 Asp23 family; Region: Asp23; cl00574 765874001029 Asp23 family; Region: Asp23; pfam03780 765874001030 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 765874001031 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 765874001032 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 765874001033 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 765874001034 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 765874001035 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 765874001036 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 765874001037 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 765874001038 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 765874001039 putative translocon binding site; other site 765874001040 protein-rRNA interface [nucleotide binding]; other site 765874001041 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 765874001042 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 765874001043 G-X-X-G motif; other site 765874001044 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 765874001045 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 765874001046 23S rRNA interface [nucleotide binding]; other site 765874001047 5S rRNA interface [nucleotide binding]; other site 765874001048 putative antibiotic binding site [chemical binding]; other site 765874001049 L25 interface [polypeptide binding]; other site 765874001050 L27 interface [polypeptide binding]; other site 765874001051 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 765874001052 putative translocon interaction site; other site 765874001053 23S rRNA interface [nucleotide binding]; other site 765874001054 signal recognition particle (SRP54) interaction site; other site 765874001055 L23 interface [polypeptide binding]; other site 765874001056 trigger factor interaction site; other site 765874001057 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 765874001058 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 765874001059 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 765874001060 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 765874001061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874001062 Walker A/P-loop; other site 765874001063 ATP binding site [chemical binding]; other site 765874001064 Q-loop/lid; other site 765874001065 ABC transporter signature motif; other site 765874001066 Walker B; other site 765874001067 D-loop; other site 765874001068 H-loop/switch region; other site 765874001069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874001070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874001071 Walker A/P-loop; other site 765874001072 ATP binding site [chemical binding]; other site 765874001073 Q-loop/lid; other site 765874001074 ABC transporter signature motif; other site 765874001075 Walker B; other site 765874001076 D-loop; other site 765874001077 H-loop/switch region; other site 765874001078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874001079 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 765874001080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001081 dimer interface [polypeptide binding]; other site 765874001082 conserved gate region; other site 765874001083 putative PBP binding loops; other site 765874001084 ABC-ATPase subunit interface; other site 765874001085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874001086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001087 putative PBP binding loops; other site 765874001088 dimer interface [polypeptide binding]; other site 765874001089 ABC-ATPase subunit interface; other site 765874001090 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 765874001091 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 765874001092 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 765874001093 RNA binding site [nucleotide binding]; other site 765874001094 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 765874001095 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 765874001096 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 765874001097 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 765874001098 serine transporter; Region: stp; TIGR00814 765874001099 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 765874001100 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 765874001101 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 765874001102 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 765874001103 active site 765874001104 homotetramer interface [polypeptide binding]; other site 765874001105 homodimer interface [polypeptide binding]; other site 765874001106 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 765874001107 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 765874001108 active site 765874001109 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 765874001110 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 765874001111 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765874001112 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765874001113 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 765874001114 5S rRNA interface [nucleotide binding]; other site 765874001115 23S rRNA interface [nucleotide binding]; other site 765874001116 L5 interface [polypeptide binding]; other site 765874001117 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 765874001118 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 765874001119 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 765874001120 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 765874001121 23S rRNA binding site [nucleotide binding]; other site 765874001122 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 765874001123 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 765874001124 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 765874001125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001126 dimer interface [polypeptide binding]; other site 765874001127 conserved gate region; other site 765874001128 putative PBP binding loops; other site 765874001129 ABC-ATPase subunit interface; other site 765874001130 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 765874001131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001132 dimer interface [polypeptide binding]; other site 765874001133 conserved gate region; other site 765874001134 putative PBP binding loops; other site 765874001135 ABC-ATPase subunit interface; other site 765874001136 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 765874001137 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 765874001138 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 765874001139 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 765874001140 Walker A/P-loop; other site 765874001141 ATP binding site [chemical binding]; other site 765874001142 Q-loop/lid; other site 765874001143 ABC transporter signature motif; other site 765874001144 Walker B; other site 765874001145 D-loop; other site 765874001146 H-loop/switch region; other site 765874001147 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 765874001148 SecY translocase; Region: SecY; pfam00344 765874001149 adenylate kinase; Reviewed; Region: adk; PRK00279 765874001150 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 765874001151 AMP-binding site [chemical binding]; other site 765874001152 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 765874001153 potential frameshift: common BLAST hit: gi|62389448|ref|YP_224850.1| methionine aminopeptidase 765874001154 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 765874001155 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 765874001156 active site 765874001157 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 765874001158 catalytic site [active] 765874001159 BNR repeat-like domain; Region: BNR_2; pfam13088 765874001160 Asp-box motif; other site 765874001161 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 765874001162 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 765874001163 rRNA binding site [nucleotide binding]; other site 765874001164 predicted 30S ribosome binding site; other site 765874001165 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 765874001166 30S ribosomal protein S13; Region: bact_S13; TIGR03631 765874001167 30S ribosomal protein S11; Validated; Region: PRK05309 765874001168 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 765874001169 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 765874001170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765874001171 RNA binding surface [nucleotide binding]; other site 765874001172 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 765874001173 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 765874001174 alphaNTD - beta interaction site [polypeptide binding]; other site 765874001175 alphaNTD homodimer interface [polypeptide binding]; other site 765874001176 alphaNTD - beta' interaction site [polypeptide binding]; other site 765874001177 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 765874001178 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 765874001179 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 765874001180 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 765874001181 dimerization interface 3.5A [polypeptide binding]; other site 765874001182 active site 765874001183 Protein of unknown function (DUF690); Region: DUF690; cl04939 765874001184 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 765874001185 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 765874001186 active site 765874001187 catalytic residues [active] 765874001188 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 765874001189 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 765874001190 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 765874001191 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 765874001192 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 765874001193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874001194 Walker A/P-loop; other site 765874001195 ATP binding site [chemical binding]; other site 765874001196 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 765874001197 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 765874001198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 765874001199 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 765874001200 23S rRNA interface [nucleotide binding]; other site 765874001201 L3 interface [polypeptide binding]; other site 765874001202 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 765874001203 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 765874001204 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 765874001205 active site 765874001206 substrate binding site [chemical binding]; other site 765874001207 metal binding site [ion binding]; metal-binding site 765874001208 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 765874001209 alanine racemase; Reviewed; Region: alr; PRK00053 765874001210 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 765874001211 active site 765874001212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765874001213 dimer interface [polypeptide binding]; other site 765874001214 substrate binding site [chemical binding]; other site 765874001215 catalytic residues [active] 765874001216 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 765874001217 Predicted permease [General function prediction only]; Region: COG2985 765874001218 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 765874001219 TrkA-C domain; Region: TrkA_C; pfam02080 765874001220 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 765874001221 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 765874001222 Glycoprotease family; Region: Peptidase_M22; pfam00814 765874001223 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 765874001224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874001225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765874001226 Coenzyme A binding pocket [chemical binding]; other site 765874001227 UGMP family protein; Validated; Region: PRK09604 765874001228 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 765874001229 oligomerisation interface [polypeptide binding]; other site 765874001230 mobile loop; other site 765874001231 roof hairpin; other site 765874001232 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765874001233 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765874001234 ring oligomerisation interface [polypeptide binding]; other site 765874001235 ATP/Mg binding site [chemical binding]; other site 765874001236 stacking interactions; other site 765874001237 hinge regions; other site 765874001238 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 765874001239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874001240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874001241 DNA binding residues [nucleotide binding] 765874001242 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 765874001243 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 765874001244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 765874001245 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 765874001246 active site 765874001247 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 765874001248 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 765874001249 phosphate binding site [ion binding]; other site 765874001250 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 765874001251 GMP synthase; Reviewed; Region: guaA; PRK00074 765874001252 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 765874001253 AMP/PPi binding site [chemical binding]; other site 765874001254 candidate oxyanion hole; other site 765874001255 catalytic triad [active] 765874001256 potential glutamine specificity residues [chemical binding]; other site 765874001257 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 765874001258 ATP Binding subdomain [chemical binding]; other site 765874001259 Ligand Binding sites [chemical binding]; other site 765874001260 Dimerization subdomain; other site 765874001261 PspC domain; Region: PspC; cl00864 765874001262 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 765874001263 PspC domain; Region: PspC; pfam04024 765874001264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 765874001265 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 765874001266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765874001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874001268 active site 765874001269 phosphorylation site [posttranslational modification] 765874001270 intermolecular recognition site; other site 765874001271 dimerization interface [polypeptide binding]; other site 765874001272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765874001273 dimerization interface [polypeptide binding]; other site 765874001274 DNA binding residues [nucleotide binding] 765874001275 AMIN domain; Region: AMIN; pfam11741 765874001276 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 765874001277 putative dimer interface [polypeptide binding]; other site 765874001278 putative [2Fe-2S] cluster binding site [ion binding]; other site 765874001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001280 dimer interface [polypeptide binding]; other site 765874001281 conserved gate region; other site 765874001282 ABC-ATPase subunit interface; other site 765874001283 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 765874001284 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 765874001285 Walker A/P-loop; other site 765874001286 ATP binding site [chemical binding]; other site 765874001287 Q-loop/lid; other site 765874001288 ABC transporter signature motif; other site 765874001289 Walker B; other site 765874001290 D-loop; other site 765874001291 H-loop/switch region; other site 765874001292 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 765874001293 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 765874001294 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 765874001295 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 765874001296 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874001297 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765874001298 intersubunit interface [polypeptide binding]; other site 765874001299 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 765874001300 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 765874001301 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765874001302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874001303 ABC-ATPase subunit interface; other site 765874001304 dimer interface [polypeptide binding]; other site 765874001305 putative PBP binding regions; other site 765874001306 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765874001307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765874001308 ABC-ATPase subunit interface; other site 765874001309 dimer interface [polypeptide binding]; other site 765874001310 putative PBP binding regions; other site 765874001311 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 765874001312 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 765874001313 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 765874001314 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 765874001315 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 765874001316 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 765874001317 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 765874001318 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 765874001319 homodimer interface [polypeptide binding]; other site 765874001320 NADP binding site [chemical binding]; other site 765874001321 substrate binding site [chemical binding]; other site 765874001322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 765874001323 active site 765874001324 potential frameshift: common BLAST hit: gi|38233230|ref|NP_938997.1| homoserine O-acetyltransferase 765874001325 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 765874001326 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 765874001327 Htaa; Region: HtaA; pfam04213 765874001328 Htaa; Region: HtaA; pfam04213 765874001329 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 765874001330 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874001331 intersubunit interface [polypeptide binding]; other site 765874001332 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 765874001333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874001334 ABC-ATPase subunit interface; other site 765874001335 dimer interface [polypeptide binding]; other site 765874001336 putative PBP binding regions; other site 765874001337 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 765874001338 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874001339 Walker A/P-loop; other site 765874001340 ATP binding site [chemical binding]; other site 765874001341 Q-loop/lid; other site 765874001342 ABC transporter signature motif; other site 765874001343 Walker B; other site 765874001344 D-loop; other site 765874001345 H-loop/switch region; other site 765874001346 Htaa; Region: HtaA; pfam04213 765874001347 potential frameshift: common BLAST hit: gi|38233237|ref|NP_939004.1| O-acetylhomoserine aminocarboxypropyltransferase 765874001348 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765874001349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765874001350 catalytic residue [active] 765874001351 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765874001352 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765874001353 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 765874001354 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 765874001355 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 765874001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874001357 putative substrate translocation pore; other site 765874001358 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 765874001359 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 765874001360 DNA binding residues [nucleotide binding] 765874001361 dimer interface [polypeptide binding]; other site 765874001362 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 765874001363 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765874001364 putative catalytic site [active] 765874001365 putative metal binding site [ion binding]; other site 765874001366 putative phosphate binding site [ion binding]; other site 765874001367 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 765874001368 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 765874001369 active site 765874001370 HIGH motif; other site 765874001371 dimer interface [polypeptide binding]; other site 765874001372 KMSKS motif; other site 765874001373 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 765874001374 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 765874001375 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 765874001376 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 765874001377 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 765874001378 NlpC/P60 family; Region: NLPC_P60; pfam00877 765874001379 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874001380 active site 765874001381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 765874001382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765874001383 non-specific DNA binding site [nucleotide binding]; other site 765874001384 salt bridge; other site 765874001385 sequence-specific DNA binding site [nucleotide binding]; other site 765874001386 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 765874001387 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 765874001388 active site 765874001389 substrate binding site [chemical binding]; other site 765874001390 metal binding site [ion binding]; metal-binding site 765874001391 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 765874001392 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 765874001393 metal binding site [ion binding]; metal-binding site 765874001394 putative dimer interface [polypeptide binding]; other site 765874001395 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 765874001396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765874001397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765874001398 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765874001399 pyruvate carboxylase; Reviewed; Region: PRK12999 765874001400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765874001401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 765874001402 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 765874001403 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 765874001404 active site 765874001405 catalytic residues [active] 765874001406 metal binding site [ion binding]; metal-binding site 765874001407 homodimer binding site [polypeptide binding]; other site 765874001408 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 765874001409 carboxyltransferase (CT) interaction site; other site 765874001410 biotinylation site [posttranslational modification]; other site 765874001411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874001412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874001414 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 765874001415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765874001416 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 765874001417 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 765874001418 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 765874001419 carboxyltransferase (CT) interaction site; other site 765874001420 biotinylation site [posttranslational modification]; other site 765874001421 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 765874001422 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 765874001423 active site residue [active] 765874001424 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 765874001425 active site residue [active] 765874001426 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 765874001427 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 765874001428 Maf-like protein; Region: Maf; pfam02545 765874001429 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 765874001430 active site 765874001431 dimer interface [polypeptide binding]; other site 765874001432 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 765874001433 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 765874001434 substrate binding site [chemical binding]; other site 765874001435 ATP binding site [chemical binding]; other site 765874001436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 765874001437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 765874001438 DNA binding site [nucleotide binding] 765874001439 domain linker motif; other site 765874001440 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 765874001441 putative ligand binding site [chemical binding]; other site 765874001442 dimerization interface [polypeptide binding]; other site 765874001443 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 765874001444 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 765874001445 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 765874001446 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 765874001447 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 765874001448 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 765874001449 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 765874001450 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 765874001451 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 765874001452 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 765874001453 ATP-grasp domain; Region: ATP-grasp; pfam02222 765874001454 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 765874001455 Uncharacterized conserved protein [Function unknown]; Region: COG1434 765874001456 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 765874001457 putative active site [active] 765874001458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 765874001459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001460 dimer interface [polypeptide binding]; other site 765874001461 conserved gate region; other site 765874001462 putative PBP binding loops; other site 765874001463 ABC-ATPase subunit interface; other site 765874001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001465 dimer interface [polypeptide binding]; other site 765874001466 conserved gate region; other site 765874001467 putative PBP binding loops; other site 765874001468 ABC-ATPase subunit interface; other site 765874001469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 765874001470 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 765874001471 TIGR03089 family protein; Region: TIGR03089 765874001472 Transcriptional regulator [Transcription]; Region: LytR; COG1316 765874001473 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 765874001474 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 765874001475 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 765874001476 Probable Catalytic site; other site 765874001477 metal-binding site 765874001478 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 765874001479 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 765874001480 active site 765874001481 Substrate binding site; other site 765874001482 Mg++ binding site; other site 765874001483 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765874001484 putative trimer interface [polypeptide binding]; other site 765874001485 putative CoA binding site [chemical binding]; other site 765874001486 Transcription factor WhiB; Region: Whib; pfam02467 765874001487 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 765874001488 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 765874001489 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 765874001490 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 765874001491 active site 765874001492 substrate binding site [chemical binding]; other site 765874001493 metal binding site [ion binding]; metal-binding site 765874001494 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 765874001495 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 765874001496 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 765874001497 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 765874001498 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 765874001499 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 765874001500 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 765874001501 homotetramer interface [polypeptide binding]; other site 765874001502 ligand binding site [chemical binding]; other site 765874001503 catalytic site [active] 765874001504 NAD binding site [chemical binding]; other site 765874001505 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 765874001506 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 765874001507 TMP-binding site; other site 765874001508 ATP-binding site [chemical binding]; other site 765874001509 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765874001510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874001511 active site 765874001512 phosphorylation site [posttranslational modification] 765874001513 intermolecular recognition site; other site 765874001514 dimerization interface [polypeptide binding]; other site 765874001515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765874001516 DNA binding site [nucleotide binding] 765874001517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 765874001518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765874001519 dimerization interface [polypeptide binding]; other site 765874001520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765874001521 dimer interface [polypeptide binding]; other site 765874001522 phosphorylation site [posttranslational modification] 765874001523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874001524 ATP binding site [chemical binding]; other site 765874001525 Mg2+ binding site [ion binding]; other site 765874001526 G-X-G motif; other site 765874001527 lipoprotein LpqB; Provisional; Region: PRK13616 765874001528 Sporulation and spore germination; Region: Germane; pfam10646 765874001529 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 765874001530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874001531 active site 765874001532 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 765874001533 30S subunit binding site; other site 765874001534 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 765874001535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 765874001536 ATP binding site [chemical binding]; other site 765874001537 putative Mg++ binding site [ion binding]; other site 765874001538 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 765874001539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 765874001540 nucleotide binding region [chemical binding]; other site 765874001541 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 765874001542 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 765874001543 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 765874001544 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 765874001545 FAD binding pocket [chemical binding]; other site 765874001546 FAD binding motif [chemical binding]; other site 765874001547 phosphate binding motif [ion binding]; other site 765874001548 beta-alpha-beta structure motif; other site 765874001549 NAD binding pocket [chemical binding]; other site 765874001550 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 765874001551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765874001552 catalytic loop [active] 765874001553 iron binding site [ion binding]; other site 765874001554 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 765874001555 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 765874001556 putative di-iron ligands [ion binding]; other site 765874001557 Predicted GTPases [General function prediction only]; Region: COG1162 765874001558 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 765874001559 GTPase/Zn-binding domain interface [polypeptide binding]; other site 765874001560 GTP/Mg2+ binding site [chemical binding]; other site 765874001561 G4 box; other site 765874001562 G5 box; other site 765874001563 G1 box; other site 765874001564 Switch I region; other site 765874001565 G2 box; other site 765874001566 G3 box; other site 765874001567 Switch II region; other site 765874001568 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 765874001569 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 765874001570 hinge; other site 765874001571 active site 765874001572 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 765874001573 putative deacylase active site [active] 765874001574 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 765874001575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874001576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874001577 DNA binding residues [nucleotide binding] 765874001578 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 765874001579 Transcription factor WhiB; Region: Whib; pfam02467 765874001580 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 765874001581 active site 765874001582 catalytic triad [active] 765874001583 oxyanion hole [active] 765874001584 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 765874001585 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 765874001586 DEAD-like helicases superfamily; Region: DEXDc; smart00487 765874001587 ATP binding site [chemical binding]; other site 765874001588 Mg++ binding site [ion binding]; other site 765874001589 motif III; other site 765874001590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874001591 nucleotide binding region [chemical binding]; other site 765874001592 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 765874001593 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 765874001594 TIGR02569 family protein; Region: TIGR02569_actnb 765874001595 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 765874001596 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 765874001597 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 765874001598 Part of AAA domain; Region: AAA_19; pfam13245 765874001599 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 765874001600 Ion channel; Region: Ion_trans_2; pfam07885 765874001601 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 765874001602 TrkA-N domain; Region: TrkA_N; pfam02254 765874001603 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 765874001604 putative NADH binding site [chemical binding]; other site 765874001605 putative active site [active] 765874001606 nudix motif; other site 765874001607 putative metal binding site [ion binding]; other site 765874001608 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 765874001609 Part of AAA domain; Region: AAA_19; pfam13245 765874001610 Family description; Region: UvrD_C_2; pfam13538 765874001611 HRDC domain; Region: HRDC; pfam00570 765874001612 Protein of unknown function DUF45; Region: DUF45; cl00636 765874001613 putative hydrolase; Region: TIGR03624 765874001614 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 765874001615 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765874001616 hypothetical protein; Validated; Region: PRK00068 765874001617 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 765874001618 Abi-like protein; Region: Abi_2; pfam07751 765874001619 Predicted helicase [General function prediction only]; Region: COG4889 765874001620 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 765874001621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874001622 ATP binding site [chemical binding]; other site 765874001623 putative Mg++ binding site [ion binding]; other site 765874001624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874001625 ATP-binding site [chemical binding]; other site 765874001626 Methyltransferase domain; Region: Methyltransf_26; pfam13659 765874001627 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 765874001628 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 765874001629 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 765874001630 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 765874001631 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 765874001632 Predicted membrane protein [Function unknown]; Region: COG2311 765874001633 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 765874001634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874001635 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 765874001636 acyl-activating enzyme (AAE) consensus motif; other site 765874001637 AMP binding site [chemical binding]; other site 765874001638 active site 765874001639 CoA binding site [chemical binding]; other site 765874001640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 765874001641 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 765874001642 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765874001643 putative trimer interface [polypeptide binding]; other site 765874001644 putative CoA binding site [chemical binding]; other site 765874001645 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765874001646 putative trimer interface [polypeptide binding]; other site 765874001647 putative CoA binding site [chemical binding]; other site 765874001648 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 765874001649 oxaloacetate decarboxylase; Provisional; Region: PRK12330 765874001650 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 765874001651 active site 765874001652 catalytic residues [active] 765874001653 metal binding site [ion binding]; metal-binding site 765874001654 homodimer binding site [polypeptide binding]; other site 765874001655 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 765874001656 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 765874001657 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 765874001658 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 765874001659 carboxyltransferase (CT) interaction site; other site 765874001660 biotinylation site [posttranslational modification]; other site 765874001661 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 765874001662 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 765874001663 active site 765874001664 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 765874001665 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 765874001666 active site 765874001667 peptide chain release factor 2; Validated; Region: prfB; PRK00578 765874001668 This domain is found in peptide chain release factors; Region: PCRF; smart00937 765874001669 RF-1 domain; Region: RF-1; pfam00472 765874001670 topology modulation protein; Provisional; Region: PRK07261 765874001671 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 765874001672 active site 765874001673 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 765874001674 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 765874001675 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 765874001676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874001677 Walker A/P-loop; other site 765874001678 ATP binding site [chemical binding]; other site 765874001679 Q-loop/lid; other site 765874001680 ABC transporter signature motif; other site 765874001681 Walker B; other site 765874001682 D-loop; other site 765874001683 H-loop/switch region; other site 765874001684 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 765874001685 FtsX-like permease family; Region: FtsX; pfam02687 765874001686 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 765874001687 SmpB-tmRNA interface; other site 765874001688 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 765874001689 active site clefts [active] 765874001690 zinc binding site [ion binding]; other site 765874001691 dimer interface [polypeptide binding]; other site 765874001692 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 765874001693 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874001694 intersubunit interface [polypeptide binding]; other site 765874001695 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874001696 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874001697 ABC-ATPase subunit interface; other site 765874001698 dimer interface [polypeptide binding]; other site 765874001699 putative PBP binding regions; other site 765874001700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874001701 ABC-ATPase subunit interface; other site 765874001702 dimer interface [polypeptide binding]; other site 765874001703 putative PBP binding regions; other site 765874001704 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 765874001705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874001706 Walker A/P-loop; other site 765874001707 ATP binding site [chemical binding]; other site 765874001708 Q-loop/lid; other site 765874001709 ABC transporter signature motif; other site 765874001710 Walker B; other site 765874001711 D-loop; other site 765874001712 H-loop/switch region; other site 765874001713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874001714 catalytic residue [active] 765874001715 homodimer interface [polypeptide binding]; other site 765874001716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874001717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874001718 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 765874001719 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 765874001720 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 765874001721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874001722 ATP binding site [chemical binding]; other site 765874001723 putative Mg++ binding site [ion binding]; other site 765874001724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874001725 nucleotide binding region [chemical binding]; other site 765874001726 ATP-binding site [chemical binding]; other site 765874001727 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 765874001728 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 765874001729 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 765874001730 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 765874001731 DNA-binding site [nucleotide binding]; DNA binding site 765874001732 RNA-binding motif; other site 765874001733 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 765874001734 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 765874001735 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 765874001736 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 765874001737 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765874001738 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765874001739 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 765874001740 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765874001741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765874001742 catalytic residue [active] 765874001743 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 765874001744 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 765874001745 dimer interface [polypeptide binding]; other site 765874001746 active site 765874001747 citrylCoA binding site [chemical binding]; other site 765874001748 NADH binding [chemical binding]; other site 765874001749 cationic pore residues; other site 765874001750 oxalacetate/citrate binding site [chemical binding]; other site 765874001751 coenzyme A binding site [chemical binding]; other site 765874001752 catalytic triad [active] 765874001753 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765874001754 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 765874001755 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 765874001756 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 765874001757 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 765874001758 E-class dimer interface [polypeptide binding]; other site 765874001759 P-class dimer interface [polypeptide binding]; other site 765874001760 active site 765874001761 Cu2+ binding site [ion binding]; other site 765874001762 Zn2+ binding site [ion binding]; other site 765874001763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765874001764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765874001765 active site 765874001766 catalytic tetrad [active] 765874001767 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 765874001768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765874001769 substrate binding site [chemical binding]; other site 765874001770 oxyanion hole (OAH) forming residues; other site 765874001771 trimer interface [polypeptide binding]; other site 765874001772 Protein of unknown function, DUF485; Region: DUF485; pfam04341 765874001773 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 765874001774 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 765874001775 Na binding site [ion binding]; other site 765874001776 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 765874001777 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 765874001778 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765874001779 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 765874001780 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 765874001781 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 765874001782 multidrug efflux protein NorA; Provisional; Region: PRK00187 765874001783 cation binding site [ion binding]; other site 765874001784 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 765874001785 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 765874001786 dimer interface [polypeptide binding]; other site 765874001787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874001788 catalytic residue [active] 765874001789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 765874001790 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765874001791 catalytic residue [active] 765874001792 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 765874001793 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 765874001794 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 765874001795 substrate binding pocket [chemical binding]; other site 765874001796 active site 765874001797 iron coordination sites [ion binding]; other site 765874001798 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 765874001799 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 765874001800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874001801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001802 dimer interface [polypeptide binding]; other site 765874001803 conserved gate region; other site 765874001804 putative PBP binding loops; other site 765874001805 ABC-ATPase subunit interface; other site 765874001806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 765874001807 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 765874001808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874001809 Walker A/P-loop; other site 765874001810 ATP binding site [chemical binding]; other site 765874001811 Q-loop/lid; other site 765874001812 ABC transporter signature motif; other site 765874001813 Walker B; other site 765874001814 D-loop; other site 765874001815 H-loop/switch region; other site 765874001816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874001817 Walker A/P-loop; other site 765874001818 ATP binding site [chemical binding]; other site 765874001819 Q-loop/lid; other site 765874001820 ABC transporter signature motif; other site 765874001821 Walker B; other site 765874001822 D-loop; other site 765874001823 H-loop/switch region; other site 765874001824 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 765874001825 active site 765874001826 SAM binding site [chemical binding]; other site 765874001827 homodimer interface [polypeptide binding]; other site 765874001828 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 765874001829 catalytic residues [active] 765874001830 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 765874001831 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 765874001832 folate binding site [chemical binding]; other site 765874001833 NADP+ binding site [chemical binding]; other site 765874001834 thymidylate synthase; Reviewed; Region: thyA; PRK01827 765874001835 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 765874001836 dimerization interface [polypeptide binding]; other site 765874001837 active site 765874001838 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 765874001839 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 765874001840 active site 765874001841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874001842 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 765874001843 ATP binding site [chemical binding]; other site 765874001844 putative Mg++ binding site [ion binding]; other site 765874001845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874001846 nucleotide binding region [chemical binding]; other site 765874001847 ATP-binding site [chemical binding]; other site 765874001848 DEAD/H associated; Region: DEAD_assoc; pfam08494 765874001849 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 765874001850 active site 765874001851 SUMO-1 interface [polypeptide binding]; other site 765874001852 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 765874001853 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 765874001854 putative DNA binding site [nucleotide binding]; other site 765874001855 putative catalytic residues [active] 765874001856 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 765874001857 hypothetical protein; Provisional; Region: PRK11770 765874001858 Domain of unknown function (DUF307); Region: DUF307; pfam03733 765874001859 Domain of unknown function (DUF307); Region: DUF307; pfam03733 765874001860 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 765874001861 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 765874001862 active site 765874001863 dimer interface [polypeptide binding]; other site 765874001864 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 765874001865 dimer interface [polypeptide binding]; other site 765874001866 active site 765874001867 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765874001868 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 765874001869 tetramerization interface [polypeptide binding]; other site 765874001870 NAD(P) binding site [chemical binding]; other site 765874001871 catalytic residues [active] 765874001872 hypothetical protein; Provisional; Region: PRK07857 765874001873 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 765874001874 Part of AAA domain; Region: AAA_19; pfam13245 765874001875 Family description; Region: UvrD_C_2; pfam13538 765874001876 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 765874001877 Peptidase family M23; Region: Peptidase_M23; pfam01551 765874001878 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 765874001879 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 765874001880 active site 765874001881 substrate binding site [chemical binding]; other site 765874001882 cosubstrate binding site; other site 765874001883 catalytic site [active] 765874001884 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 765874001885 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 765874001886 purine monophosphate binding site [chemical binding]; other site 765874001887 dimer interface [polypeptide binding]; other site 765874001888 putative catalytic residues [active] 765874001889 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 765874001890 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 765874001891 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765874001892 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 765874001893 Walker A/P-loop; other site 765874001894 ATP binding site [chemical binding]; other site 765874001895 Q-loop/lid; other site 765874001896 ABC transporter signature motif; other site 765874001897 Walker B; other site 765874001898 D-loop; other site 765874001899 H-loop/switch region; other site 765874001900 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 765874001901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765874001902 substrate binding pocket [chemical binding]; other site 765874001903 membrane-bound complex binding site; other site 765874001904 hinge residues; other site 765874001905 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 765874001906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001907 dimer interface [polypeptide binding]; other site 765874001908 conserved gate region; other site 765874001909 putative PBP binding loops; other site 765874001910 ABC-ATPase subunit interface; other site 765874001911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874001912 dimer interface [polypeptide binding]; other site 765874001913 conserved gate region; other site 765874001914 putative PBP binding loops; other site 765874001915 ABC-ATPase subunit interface; other site 765874001916 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 765874001917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874001918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874001919 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 765874001920 30S ribosomal protein S18; Provisional; Region: PRK13401 765874001921 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 765874001922 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 765874001923 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 765874001924 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 765874001925 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 765874001926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765874001927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874001928 active site 765874001929 phosphorylation site [posttranslational modification] 765874001930 intermolecular recognition site; other site 765874001931 dimerization interface [polypeptide binding]; other site 765874001932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765874001933 DNA binding site [nucleotide binding] 765874001934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 765874001935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765874001936 dimerization interface [polypeptide binding]; other site 765874001937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765874001938 dimer interface [polypeptide binding]; other site 765874001939 phosphorylation site [posttranslational modification] 765874001940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874001941 ATP binding site [chemical binding]; other site 765874001942 Mg2+ binding site [ion binding]; other site 765874001943 G-X-G motif; other site 765874001944 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 765874001945 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 765874001946 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765874001947 protein binding site [polypeptide binding]; other site 765874001948 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 765874001949 MPT binding site; other site 765874001950 trimer interface [polypeptide binding]; other site 765874001951 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 765874001952 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 765874001953 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 765874001954 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 765874001955 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 765874001956 active site 765874001957 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 765874001958 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 765874001959 dimer interface [polypeptide binding]; other site 765874001960 putative functional site; other site 765874001961 putative MPT binding site; other site 765874001962 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 765874001963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874001964 Coenzyme A binding pocket [chemical binding]; other site 765874001965 Predicted membrane protein [Function unknown]; Region: COG2259 765874001966 Predicted integral membrane protein [Function unknown]; Region: COG5660 765874001967 Putative zinc-finger; Region: zf-HC2; pfam13490 765874001968 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 765874001969 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 765874001970 BCCT family transporter; Region: BCCT; pfam02028 765874001971 Uncharacterized membrane protein [Function unknown]; Region: COG3949 765874001972 Predicted methyltransferases [General function prediction only]; Region: COG0313 765874001973 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 765874001974 putative SAM binding site [chemical binding]; other site 765874001975 putative homodimer interface [polypeptide binding]; other site 765874001976 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 765874001977 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 765874001978 active site 765874001979 HIGH motif; other site 765874001980 KMSKS motif; other site 765874001981 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 765874001982 tRNA binding surface [nucleotide binding]; other site 765874001983 anticodon binding site; other site 765874001984 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 765874001985 active site 765874001986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 765874001987 Domain of unknown function (DUF348); Region: DUF348; pfam03990 765874001988 Domain of unknown function (DUF348); Region: DUF348; pfam03990 765874001989 G5 domain; Region: G5; pfam07501 765874001990 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 765874001991 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 765874001992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874001993 S-adenosylmethionine binding site [chemical binding]; other site 765874001994 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 765874001995 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765874001996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874001997 ABC transporter; Region: ABC_tran_2; pfam12848 765874001998 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874001999 Uncharacterized conserved protein [Function unknown]; Region: COG1359 765874002000 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 765874002001 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 765874002002 potential frameshift: common BLAST hit: gi|62389808|ref|YP_225210.1| HAD family hydrolase 765874002003 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 765874002004 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 765874002005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874002006 active site 765874002007 motif I; other site 765874002008 motif II; other site 765874002009 potential frameshift: common BLAST hit: gi|38233482|ref|NP_939249.1| 3-hydroxyisobutyryl-CoA hydrolase 765874002010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765874002011 substrate binding site [chemical binding]; other site 765874002012 oxyanion hole (OAH) forming residues; other site 765874002013 trimer interface [polypeptide binding]; other site 765874002014 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 765874002015 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 765874002016 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 765874002017 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 765874002018 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 765874002019 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 765874002020 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 765874002021 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 765874002022 G1 box; other site 765874002023 putative GEF interaction site [polypeptide binding]; other site 765874002024 GTP/Mg2+ binding site [chemical binding]; other site 765874002025 Switch I region; other site 765874002026 G2 box; other site 765874002027 G3 box; other site 765874002028 Switch II region; other site 765874002029 G4 box; other site 765874002030 G5 box; other site 765874002031 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 765874002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874002033 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 765874002034 NAD(P) binding site [chemical binding]; other site 765874002035 active site 765874002036 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 765874002037 putative active site [active] 765874002038 catalytic residue [active] 765874002039 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 765874002040 FMN binding site [chemical binding]; other site 765874002041 substrate binding site [chemical binding]; other site 765874002042 putative catalytic residue [active] 765874002043 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 765874002044 putative active site [active] 765874002045 catalytic residue [active] 765874002046 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 765874002047 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 765874002048 5S rRNA interface [nucleotide binding]; other site 765874002049 CTC domain interface [polypeptide binding]; other site 765874002050 L16 interface [polypeptide binding]; other site 765874002051 pullulanase, type I; Region: pulA_typeI; TIGR02104 765874002052 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 765874002053 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 765874002054 Ca binding site [ion binding]; other site 765874002055 active site 765874002056 catalytic site [active] 765874002057 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 765874002058 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 765874002059 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874002060 active site 765874002061 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 765874002062 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 765874002063 Substrate binding site; other site 765874002064 Mg++ binding site; other site 765874002065 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 765874002066 active site 765874002067 substrate binding site [chemical binding]; other site 765874002068 CoA binding site [chemical binding]; other site 765874002069 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 765874002070 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 765874002071 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 765874002072 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 765874002073 gating phenylalanine in ion channel; other site 765874002074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874002075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874002076 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 765874002077 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 765874002078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874002079 ATP binding site [chemical binding]; other site 765874002080 putative Mg++ binding site [ion binding]; other site 765874002081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874002082 nucleotide binding region [chemical binding]; other site 765874002083 ATP-binding site [chemical binding]; other site 765874002084 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 765874002085 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 765874002086 Spore germination protein; Region: Spore_permease; cl17796 765874002087 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 765874002088 homodimer interface [polypeptide binding]; other site 765874002089 metal binding site [ion binding]; metal-binding site 765874002090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 765874002091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 765874002092 enolase; Provisional; Region: eno; PRK00077 765874002093 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 765874002094 dimer interface [polypeptide binding]; other site 765874002095 metal binding site [ion binding]; metal-binding site 765874002096 substrate binding pocket [chemical binding]; other site 765874002097 Septum formation initiator; Region: DivIC; pfam04977 765874002098 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 765874002099 Uncharacterized conserved protein [Function unknown]; Region: COG1507 765874002100 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 765874002101 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 765874002102 Helix-turn-helix domain; Region: HTH_18; pfam12833 765874002103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 765874002104 Bax inhibitor 1 like; Region: BaxI_1; cl17691 765874002105 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 765874002106 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 765874002107 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 765874002108 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 765874002109 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 765874002110 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 765874002111 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 765874002112 catalytic residue [active] 765874002113 putative FPP diphosphate binding site; other site 765874002114 putative FPP binding hydrophobic cleft; other site 765874002115 dimer interface [polypeptide binding]; other site 765874002116 putative IPP diphosphate binding site; other site 765874002117 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 765874002118 pantothenate kinase; Provisional; Region: PRK05439 765874002119 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 765874002120 ATP-binding site [chemical binding]; other site 765874002121 CoA-binding site [chemical binding]; other site 765874002122 Mg2+-binding site [ion binding]; other site 765874002123 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 765874002124 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 765874002125 dimer interface [polypeptide binding]; other site 765874002126 active site 765874002127 glycine-pyridoxal phosphate binding site [chemical binding]; other site 765874002128 folate binding site [chemical binding]; other site 765874002129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874002130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874002131 putative substrate translocation pore; other site 765874002132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874002133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874002134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 765874002135 dimerization interface [polypeptide binding]; other site 765874002136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765874002137 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 765874002138 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 765874002139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874002140 Coenzyme A binding pocket [chemical binding]; other site 765874002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874002142 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 765874002143 putative substrate translocation pore; other site 765874002144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874002146 fumarate hydratase; Reviewed; Region: fumC; PRK00485 765874002147 Class II fumarases; Region: Fumarase_classII; cd01362 765874002148 active site 765874002149 tetramer interface [polypeptide binding]; other site 765874002150 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 765874002151 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 765874002152 putative active site [active] 765874002153 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 765874002154 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 765874002155 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 765874002156 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 765874002157 generic binding surface II; other site 765874002158 generic binding surface I; other site 765874002159 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 765874002160 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 765874002161 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 765874002162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 765874002163 Domain of unknown function DUF20; Region: UPF0118; pfam01594 765874002164 GTP-binding protein YchF; Reviewed; Region: PRK09601 765874002165 YchF GTPase; Region: YchF; cd01900 765874002166 G1 box; other site 765874002167 GTP/Mg2+ binding site [chemical binding]; other site 765874002168 Switch I region; other site 765874002169 G2 box; other site 765874002170 Switch II region; other site 765874002171 G3 box; other site 765874002172 G4 box; other site 765874002173 G5 box; other site 765874002174 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 765874002175 Protein of unknown function, DUF488; Region: DUF488; pfam04343 765874002176 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 765874002177 PhnA protein; Region: PhnA; pfam03831 765874002178 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765874002179 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765874002180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002181 Walker A/P-loop; other site 765874002182 ATP binding site [chemical binding]; other site 765874002183 Q-loop/lid; other site 765874002184 ABC transporter signature motif; other site 765874002185 Walker B; other site 765874002186 D-loop; other site 765874002187 H-loop/switch region; other site 765874002188 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 765874002189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765874002190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002191 Walker A/P-loop; other site 765874002192 ATP binding site [chemical binding]; other site 765874002193 Q-loop/lid; other site 765874002194 ABC transporter signature motif; other site 765874002195 Walker B; other site 765874002196 D-loop; other site 765874002197 H-loop/switch region; other site 765874002198 potential frameshift: common BLAST hit: gi|62389974|ref|YP_225376.1| excinuclease ATPase subunit-UvrA-like protein 765874002199 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 765874002200 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765874002201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002202 Walker A/P-loop; other site 765874002203 ATP binding site [chemical binding]; other site 765874002204 Q-loop/lid; other site 765874002205 ABC transporter signature motif; other site 765874002206 Walker B; other site 765874002207 D-loop; other site 765874002208 H-loop/switch region; other site 765874002209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002210 Walker A/P-loop; other site 765874002211 ATP binding site [chemical binding]; other site 765874002212 Q-loop/lid; other site 765874002213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 765874002214 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 765874002215 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 765874002216 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 765874002217 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 765874002218 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 765874002219 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 765874002220 Walker A/P-loop; other site 765874002221 ATP binding site [chemical binding]; other site 765874002222 Q-loop/lid; other site 765874002223 ABC transporter signature motif; other site 765874002224 Walker B; other site 765874002225 D-loop; other site 765874002226 H-loop/switch region; other site 765874002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002228 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 765874002229 Walker A/P-loop; other site 765874002230 ATP binding site [chemical binding]; other site 765874002231 Q-loop/lid; other site 765874002232 ABC transporter signature motif; other site 765874002233 Walker B; other site 765874002234 D-loop; other site 765874002235 H-loop/switch region; other site 765874002236 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 765874002237 hypothetical protein; Provisional; Region: PRK06547 765874002238 Predicted kinase [General function prediction only]; Region: COG0645 765874002239 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 765874002240 nudix motif; other site 765874002241 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 765874002242 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 765874002243 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874002244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874002245 dimer interface [polypeptide binding]; other site 765874002246 conserved gate region; other site 765874002247 ABC-ATPase subunit interface; other site 765874002248 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 765874002249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874002250 dimer interface [polypeptide binding]; other site 765874002251 conserved gate region; other site 765874002252 putative PBP binding loops; other site 765874002253 ABC-ATPase subunit interface; other site 765874002254 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 765874002255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874002256 Walker A/P-loop; other site 765874002257 ATP binding site [chemical binding]; other site 765874002258 Q-loop/lid; other site 765874002259 ABC transporter signature motif; other site 765874002260 Walker B; other site 765874002261 D-loop; other site 765874002262 H-loop/switch region; other site 765874002263 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874002264 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874002265 Walker A/P-loop; other site 765874002266 ATP binding site [chemical binding]; other site 765874002267 Q-loop/lid; other site 765874002268 ABC transporter signature motif; other site 765874002269 Walker B; other site 765874002270 D-loop; other site 765874002271 H-loop/switch region; other site 765874002272 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874002273 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 765874002274 cleavage site 765874002275 active site 765874002276 substrate binding sites [chemical binding]; other site 765874002277 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 765874002278 ArsC family; Region: ArsC; pfam03960 765874002279 catalytic residues [active] 765874002280 Protein of unknown function (DUF402); Region: DUF402; cl00979 765874002281 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 765874002282 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 765874002283 G1 box; other site 765874002284 GTP/Mg2+ binding site [chemical binding]; other site 765874002285 G2 box; other site 765874002286 Switch I region; other site 765874002287 G3 box; other site 765874002288 Switch II region; other site 765874002289 G4 box; other site 765874002290 G5 box; other site 765874002291 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 765874002292 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 765874002293 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 765874002294 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 765874002295 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 765874002296 Ferredoxin [Energy production and conversion]; Region: COG1146 765874002297 4Fe-4S binding domain; Region: Fer4; pfam00037 765874002298 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 765874002299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874002300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874002301 homodimer interface [polypeptide binding]; other site 765874002302 catalytic residue [active] 765874002303 Predicted membrane protein [Function unknown]; Region: COG2246 765874002304 GtrA-like protein; Region: GtrA; pfam04138 765874002305 Domain of unknown function (DUF222); Region: DUF222; pfam02720 765874002306 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 765874002307 active site 765874002308 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 765874002309 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765874002310 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 765874002311 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 765874002312 putative trimer interface [polypeptide binding]; other site 765874002313 putative CoA binding site [chemical binding]; other site 765874002314 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 765874002315 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765874002316 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 765874002317 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765874002318 putative trimer interface [polypeptide binding]; other site 765874002319 putative CoA binding site [chemical binding]; other site 765874002320 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 765874002321 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 765874002322 metal binding site [ion binding]; metal-binding site 765874002323 putative dimer interface [polypeptide binding]; other site 765874002324 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 765874002325 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 765874002326 dihydropteroate synthase; Region: DHPS; TIGR01496 765874002327 substrate binding pocket [chemical binding]; other site 765874002328 dimer interface [polypeptide binding]; other site 765874002329 inhibitor binding site; inhibition site 765874002330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 765874002331 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 765874002332 Ligand binding site; other site 765874002333 Putative Catalytic site; other site 765874002334 DXD motif; other site 765874002335 DivIVA domain; Region: DivI1A_domain; TIGR03544 765874002336 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 765874002337 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 765874002338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874002339 S-adenosylmethionine binding site [chemical binding]; other site 765874002340 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 765874002341 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 765874002342 active site 765874002343 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 765874002344 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 765874002345 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 765874002346 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 765874002347 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 765874002348 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 765874002349 ligand binding site; other site 765874002350 oligomer interface; other site 765874002351 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 765874002352 dimer interface [polypeptide binding]; other site 765874002353 N-terminal domain interface [polypeptide binding]; other site 765874002354 sulfate 1 binding site; other site 765874002355 Methyltransferase domain; Region: Methyltransf_24; pfam13578 765874002356 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 765874002357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874002358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874002359 DNA binding residues [nucleotide binding] 765874002360 sec-independent translocase; Provisional; Region: tatB; PRK00182 765874002361 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 765874002362 Domain of unknown function DUF59; Region: DUF59; pfam01883 765874002363 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 765874002364 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 765874002365 Predicted membrane protein [Function unknown]; Region: COG4420 765874002366 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765874002367 MgtE intracellular N domain; Region: MgtE_N; smart00924 765874002368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765874002369 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 765874002370 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 765874002371 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 765874002372 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 765874002373 TPP-binding site [chemical binding]; other site 765874002374 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 765874002375 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765874002376 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765874002377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002378 Walker A/P-loop; other site 765874002379 ATP binding site [chemical binding]; other site 765874002380 Q-loop/lid; other site 765874002381 ABC transporter signature motif; other site 765874002382 Walker B; other site 765874002383 D-loop; other site 765874002384 H-loop/switch region; other site 765874002385 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765874002386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765874002387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002388 Walker A/P-loop; other site 765874002389 ATP binding site [chemical binding]; other site 765874002390 Q-loop/lid; other site 765874002391 ABC transporter signature motif; other site 765874002392 Walker B; other site 765874002393 D-loop; other site 765874002394 H-loop/switch region; other site 765874002395 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 765874002396 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 765874002397 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 765874002398 shikimate binding site; other site 765874002399 NAD(P) binding site [chemical binding]; other site 765874002400 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 765874002401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 765874002402 substrate binding pocket [chemical binding]; other site 765874002403 catalytic triad [active] 765874002404 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 765874002405 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 765874002406 active site 765874002407 catalytic residues [active] 765874002408 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 765874002409 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 765874002410 Na binding site [ion binding]; other site 765874002411 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 765874002412 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765874002413 nucleotide binding site/active site [active] 765874002414 HIT family signature motif; other site 765874002415 catalytic residue [active] 765874002416 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 765874002417 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 765874002418 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 765874002419 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 765874002420 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 765874002421 ATP binding site [chemical binding]; other site 765874002422 Mg++ binding site [ion binding]; other site 765874002423 motif III; other site 765874002424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874002425 nucleotide binding region [chemical binding]; other site 765874002426 ATP-binding site [chemical binding]; other site 765874002427 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 765874002428 putative RNA binding site [nucleotide binding]; other site 765874002429 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 765874002430 dimer interface [polypeptide binding]; other site 765874002431 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765874002432 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 765874002433 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 765874002434 Na binding site [ion binding]; other site 765874002435 SNF2 Helicase protein; Region: DUF3670; pfam12419 765874002436 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 765874002437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874002438 ATP binding site [chemical binding]; other site 765874002439 putative Mg++ binding site [ion binding]; other site 765874002440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874002441 nucleotide binding region [chemical binding]; other site 765874002442 ATP-binding site [chemical binding]; other site 765874002443 Uncharacterized conserved protein [Function unknown]; Region: COG4279 765874002444 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 765874002445 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 765874002446 active site 765874002447 metal binding site [ion binding]; metal-binding site 765874002448 DNA binding site [nucleotide binding] 765874002449 AAA domain; Region: AAA_23; pfam13476 765874002450 Uncharacterized conserved protein [Function unknown]; Region: COG2353 765874002451 Transcriptional regulators [Transcription]; Region: MarR; COG1846 765874002452 MarR family; Region: MarR_2; pfam12802 765874002453 PspC domain; Region: PspC; pfam04024 765874002454 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 765874002455 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 765874002456 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 765874002457 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 765874002458 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 765874002459 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 765874002460 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 765874002461 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 765874002462 Cysteine-rich domain; Region: CCG; pfam02754 765874002463 Cysteine-rich domain; Region: CCG; pfam02754 765874002464 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 765874002465 L-lactate permease; Region: Lactate_perm; cl00701 765874002466 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 765874002467 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 765874002468 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 765874002469 active site 765874002470 HIGH motif; other site 765874002471 KMSK motif region; other site 765874002472 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 765874002473 tRNA binding surface [nucleotide binding]; other site 765874002474 anticodon binding site; other site 765874002475 diaminopimelate decarboxylase; Region: lysA; TIGR01048 765874002476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 765874002477 active site 765874002478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765874002479 substrate binding site [chemical binding]; other site 765874002480 catalytic residues [active] 765874002481 dimer interface [polypeptide binding]; other site 765874002482 homoserine dehydrogenase; Provisional; Region: PRK06349 765874002483 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 765874002484 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 765874002485 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 765874002486 homoserine kinase; Provisional; Region: PRK01212 765874002487 Predicted transcriptional regulator [Transcription]; Region: COG2345 765874002488 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 765874002489 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 765874002490 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874002491 acyl-activating enzyme (AAE) consensus motif; other site 765874002492 AMP binding site [chemical binding]; other site 765874002493 active site 765874002494 CoA binding site [chemical binding]; other site 765874002495 transcription termination factor Rho; Provisional; Region: PRK12678 765874002496 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 765874002497 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765874002498 RNA binding site [nucleotide binding]; other site 765874002499 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 765874002500 multimer interface [polypeptide binding]; other site 765874002501 Walker A motif; other site 765874002502 ATP binding site [chemical binding]; other site 765874002503 Walker B motif; other site 765874002504 peptide chain release factor 1; Validated; Region: prfA; PRK00591 765874002505 This domain is found in peptide chain release factors; Region: PCRF; smart00937 765874002506 RF-1 domain; Region: RF-1; pfam00472 765874002507 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 765874002508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874002509 S-adenosylmethionine binding site [chemical binding]; other site 765874002510 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 765874002511 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 765874002512 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 765874002513 Mg++ binding site [ion binding]; other site 765874002514 putative catalytic motif [active] 765874002515 substrate binding site [chemical binding]; other site 765874002516 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 765874002517 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 765874002518 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 765874002519 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 765874002520 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 765874002521 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 765874002522 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 765874002523 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765874002524 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 765874002525 beta subunit interaction interface [polypeptide binding]; other site 765874002526 Walker A motif; other site 765874002527 ATP binding site [chemical binding]; other site 765874002528 Walker B motif; other site 765874002529 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765874002530 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 765874002531 core domain interface [polypeptide binding]; other site 765874002532 delta subunit interface [polypeptide binding]; other site 765874002533 epsilon subunit interface [polypeptide binding]; other site 765874002534 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 765874002535 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765874002536 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 765874002537 alpha subunit interaction interface [polypeptide binding]; other site 765874002538 Walker A motif; other site 765874002539 ATP binding site [chemical binding]; other site 765874002540 Walker B motif; other site 765874002541 inhibitor binding site; inhibition site 765874002542 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765874002543 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 765874002544 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 765874002545 gamma subunit interface [polypeptide binding]; other site 765874002546 epsilon subunit interface [polypeptide binding]; other site 765874002547 LBP interface [polypeptide binding]; other site 765874002548 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 765874002549 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 765874002550 hypothetical protein; Provisional; Region: PRK03298 765874002551 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 765874002552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765874002553 dimer interface [polypeptide binding]; other site 765874002554 substrate binding site [chemical binding]; other site 765874002555 metal binding site [ion binding]; metal-binding site 765874002556 Domain of unknown function DUF77; Region: DUF77; pfam01910 765874002557 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 765874002558 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 765874002559 glycogen branching enzyme; Provisional; Region: PRK05402 765874002560 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 765874002561 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 765874002562 active site 765874002563 catalytic site [active] 765874002564 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 765874002565 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 765874002566 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 765874002567 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 765874002568 active site 765874002569 catalytic site [active] 765874002570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874002571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874002572 Walker A/P-loop; other site 765874002573 ATP binding site [chemical binding]; other site 765874002574 ABC transporter signature motif; other site 765874002575 Walker B; other site 765874002576 D-loop; other site 765874002577 H-loop/switch region; other site 765874002578 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 765874002579 Ligand binding site [chemical binding]; other site 765874002580 Electron transfer flavoprotein domain; Region: ETF; pfam01012 765874002581 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 765874002582 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 765874002583 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 765874002584 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 765874002585 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 765874002586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765874002587 catalytic residue [active] 765874002588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874002589 S-adenosylmethionine binding site [chemical binding]; other site 765874002590 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 765874002591 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 765874002592 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 765874002593 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765874002594 active site 765874002595 catalytic site [active] 765874002596 substrate binding site [chemical binding]; other site 765874002597 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 765874002598 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 765874002599 nucleotide binding pocket [chemical binding]; other site 765874002600 K-X-D-G motif; other site 765874002601 catalytic site [active] 765874002602 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 765874002603 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 765874002604 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 765874002605 Dimer interface [polypeptide binding]; other site 765874002606 BRCT sequence motif; other site 765874002607 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 765874002608 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 765874002609 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 765874002610 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 765874002611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765874002612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874002613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874002614 putative substrate translocation pore; other site 765874002615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874002616 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874002617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874002618 ABC-ATPase subunit interface; other site 765874002619 dimer interface [polypeptide binding]; other site 765874002620 putative PBP binding regions; other site 765874002621 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874002622 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874002623 Walker A/P-loop; other site 765874002624 ATP binding site [chemical binding]; other site 765874002625 Q-loop/lid; other site 765874002626 ABC transporter signature motif; other site 765874002627 Walker B; other site 765874002628 D-loop; other site 765874002629 H-loop/switch region; other site 765874002630 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 765874002631 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 765874002632 putative ligand binding residues [chemical binding]; other site 765874002633 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 765874002634 phosphofructokinase; Region: PFK_mixed; TIGR02483 765874002635 active site 765874002636 ADP/pyrophosphate binding site [chemical binding]; other site 765874002637 dimerization interface [polypeptide binding]; other site 765874002638 allosteric effector site; other site 765874002639 fructose-1,6-bisphosphate binding site; other site 765874002640 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 765874002641 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 765874002642 GatB domain; Region: GatB_Yqey; smart00845 765874002643 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765874002644 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765874002645 active site 765874002646 catalytic tetrad [active] 765874002647 Lysine efflux permease [General function prediction only]; Region: COG1279 765874002648 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 765874002649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 765874002650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765874002651 dimerization interface [polypeptide binding]; other site 765874002652 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 765874002653 Predicted membrane protein [Function unknown]; Region: COG2259 765874002654 potential frameshift: common BLAST hit: gi|38233690|ref|NP_939457.1| dihydroxy-acid dehydratase 765874002655 Dehydratase family; Region: ILVD_EDD; cl00340 765874002656 Dehydratase family; Region: ILVD_EDD; cl00340 765874002657 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 765874002658 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 765874002659 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765874002660 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 765874002661 potential frameshift: common BLAST hit: gi|38233692|ref|NP_939459.1| acetolactate synthase 1 catalytic subunit 765874002662 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 765874002663 PYR/PP interface [polypeptide binding]; other site 765874002664 dimer interface [polypeptide binding]; other site 765874002665 TPP binding site [chemical binding]; other site 765874002666 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 765874002667 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 765874002668 TPP-binding site [chemical binding]; other site 765874002669 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 765874002670 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 765874002671 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 765874002672 putative valine binding site [chemical binding]; other site 765874002673 dimer interface [polypeptide binding]; other site 765874002674 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 765874002675 ketol-acid reductoisomerase; Provisional; Region: PRK05479 765874002676 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 765874002677 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 765874002678 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 765874002679 Uncharacterized conserved protein [Function unknown]; Region: COG1479 765874002680 Protein of unknown function DUF262; Region: DUF262; pfam03235 765874002681 Uncharacterized conserved protein [Function unknown]; Region: COG3472 765874002682 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 765874002683 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 765874002684 ligand binding site [chemical binding]; other site 765874002685 NAD binding site [chemical binding]; other site 765874002686 dimerization interface [polypeptide binding]; other site 765874002687 catalytic site [active] 765874002688 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 765874002689 putative L-serine binding site [chemical binding]; other site 765874002690 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 765874002691 tartrate dehydrogenase; Region: TTC; TIGR02089 765874002692 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 765874002693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 765874002694 ligand binding site [chemical binding]; other site 765874002695 flexible hinge region; other site 765874002696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 765874002697 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 765874002698 metal binding triad; other site 765874002699 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 765874002700 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765874002701 active site 765874002702 catalytic site [active] 765874002703 substrate binding site [chemical binding]; other site 765874002704 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 765874002705 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 765874002706 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 765874002707 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 765874002708 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 765874002709 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765874002710 active site 765874002711 HIGH motif; other site 765874002712 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765874002713 active site 765874002714 KMSKS motif; other site 765874002715 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 765874002716 Cutinase; Region: Cutinase; pfam01083 765874002717 biotin synthase; Region: bioB; TIGR00433 765874002718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874002719 FeS/SAM binding site; other site 765874002720 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 765874002721 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 765874002722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765874002723 Zn2+ binding site [ion binding]; other site 765874002724 Mg2+ binding site [ion binding]; other site 765874002725 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 765874002726 Transcriptional regulator [Transcription]; Region: IclR; COG1414 765874002727 Bacterial transcriptional regulator; Region: IclR; pfam01614 765874002728 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 765874002729 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 765874002730 substrate binding site [chemical binding]; other site 765874002731 ligand binding site [chemical binding]; other site 765874002732 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 765874002733 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 765874002734 substrate binding site [chemical binding]; other site 765874002735 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 765874002736 active site 765874002737 Ap6A binding site [chemical binding]; other site 765874002738 nudix motif; other site 765874002739 metal binding site [ion binding]; metal-binding site 765874002740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874002741 catalytic core [active] 765874002742 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 765874002743 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 765874002744 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 765874002745 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 765874002746 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 765874002747 ATP-grasp domain; Region: ATP-grasp_4; cl17255 765874002748 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 765874002749 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 765874002750 thiamine monophosphate kinase; Provisional; Region: PRK05731 765874002751 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 765874002752 ATP binding site [chemical binding]; other site 765874002753 dimerization interface [polypeptide binding]; other site 765874002754 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 765874002755 ligand binding site [chemical binding]; other site 765874002756 active site 765874002757 UGI interface [polypeptide binding]; other site 765874002758 catalytic site [active] 765874002759 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 765874002760 DAK2 domain; Region: Dak2; pfam02734 765874002761 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 765874002762 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 765874002763 generic binding surface II; other site 765874002764 ssDNA binding site; other site 765874002765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874002766 ATP binding site [chemical binding]; other site 765874002767 putative Mg++ binding site [ion binding]; other site 765874002768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874002769 nucleotide binding region [chemical binding]; other site 765874002770 ATP-binding site [chemical binding]; other site 765874002771 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 765874002772 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 765874002773 carboxyltransferase (CT) interaction site; other site 765874002774 biotinylation site [posttranslational modification]; other site 765874002775 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 765874002776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874002777 S-adenosylmethionine binding site [chemical binding]; other site 765874002778 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 765874002779 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 765874002780 active site 765874002781 (T/H)XGH motif; other site 765874002782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 765874002783 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 765874002784 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765874002785 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 765874002786 Walker A/P-loop; other site 765874002787 ATP binding site [chemical binding]; other site 765874002788 Q-loop/lid; other site 765874002789 ABC transporter signature motif; other site 765874002790 Walker B; other site 765874002791 D-loop; other site 765874002792 H-loop/switch region; other site 765874002793 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 765874002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874002795 dimer interface [polypeptide binding]; other site 765874002796 conserved gate region; other site 765874002797 putative PBP binding loops; other site 765874002798 ABC-ATPase subunit interface; other site 765874002799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765874002800 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765874002801 substrate binding pocket [chemical binding]; other site 765874002802 membrane-bound complex binding site; other site 765874002803 hinge residues; other site 765874002804 Domain of unknown function (DUF368); Region: DUF368; pfam04018 765874002805 DNA polymerase I; Provisional; Region: PRK05755 765874002806 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 765874002807 active site 765874002808 metal binding site 1 [ion binding]; metal-binding site 765874002809 putative 5' ssDNA interaction site; other site 765874002810 metal binding site 3; metal-binding site 765874002811 metal binding site 2 [ion binding]; metal-binding site 765874002812 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 765874002813 putative DNA binding site [nucleotide binding]; other site 765874002814 putative metal binding site [ion binding]; other site 765874002815 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 765874002816 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 765874002817 active site 765874002818 DNA binding site [nucleotide binding] 765874002819 catalytic site [active] 765874002820 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 765874002821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874002822 S-adenosylmethionine binding site [chemical binding]; other site 765874002823 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 765874002824 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 765874002825 RNA binding site [nucleotide binding]; other site 765874002826 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 765874002827 RNA binding site [nucleotide binding]; other site 765874002828 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765874002829 RNA binding site [nucleotide binding]; other site 765874002830 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 765874002831 RNA binding site [nucleotide binding]; other site 765874002832 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 765874002833 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 765874002834 active site turn [active] 765874002835 phosphorylation site [posttranslational modification] 765874002836 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 765874002837 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 765874002838 HPr interaction site; other site 765874002839 glycerol kinase (GK) interaction site [polypeptide binding]; other site 765874002840 active site 765874002841 phosphorylation site [posttranslational modification] 765874002842 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 765874002843 ATP-binding [chemical binding]; other site 765874002844 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 765874002845 CoA-binding site [chemical binding]; other site 765874002846 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 765874002847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874002848 FeS/SAM binding site; other site 765874002849 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 765874002850 excinuclease ABC subunit B; Provisional; Region: PRK05298 765874002851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874002852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874002853 nucleotide binding region [chemical binding]; other site 765874002854 ATP-binding site [chemical binding]; other site 765874002855 Ultra-violet resistance protein B; Region: UvrB; pfam12344 765874002856 UvrB/uvrC motif; Region: UVR; pfam02151 765874002857 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765874002858 Ligand Binding Site [chemical binding]; other site 765874002859 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 765874002860 Part of AAA domain; Region: AAA_19; pfam13245 765874002861 Family description; Region: UvrD_C_2; pfam13538 765874002862 Predicted membrane protein [Function unknown]; Region: COG2259 765874002863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 765874002864 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 765874002865 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765874002866 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765874002867 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 765874002868 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 765874002869 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 765874002870 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 765874002871 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 765874002872 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 765874002873 23S rRNA binding site [nucleotide binding]; other site 765874002874 L21 binding site [polypeptide binding]; other site 765874002875 L13 binding site [polypeptide binding]; other site 765874002876 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765874002877 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 765874002878 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765874002879 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 765874002880 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 765874002881 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 765874002882 dimer interface [polypeptide binding]; other site 765874002883 motif 1; other site 765874002884 active site 765874002885 motif 2; other site 765874002886 motif 3; other site 765874002887 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 765874002888 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 765874002889 putative tRNA-binding site [nucleotide binding]; other site 765874002890 B3/4 domain; Region: B3_4; pfam03483 765874002891 tRNA synthetase B5 domain; Region: B5; smart00874 765874002892 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 765874002893 dimer interface [polypeptide binding]; other site 765874002894 motif 1; other site 765874002895 motif 3; other site 765874002896 motif 2; other site 765874002897 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 765874002898 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 765874002899 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 765874002900 potential frameshift: common BLAST hit: gi|38233758|ref|NP_939525.1| bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 765874002901 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 765874002902 active site pocket [active] 765874002903 cleavage site 765874002904 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 765874002905 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 765874002906 feedback inhibition sensing region; other site 765874002907 homohexameric interface [polypeptide binding]; other site 765874002908 nucleotide binding site [chemical binding]; other site 765874002909 N-acetyl-L-glutamate binding site [chemical binding]; other site 765874002910 potential frameshift: common BLAST hit: gi|38233760|ref|NP_939527.1| acetylornithine aminotransferase 765874002911 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765874002912 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765874002913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874002914 catalytic residue [active] 765874002915 ornithine carbamoyltransferase; Provisional; Region: PRK00779 765874002916 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 765874002917 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 765874002918 arginine repressor; Provisional; Region: PRK03341 765874002919 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 765874002920 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 765874002921 argininosuccinate synthase; Provisional; Region: PRK13820 765874002922 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 765874002923 ANP binding site [chemical binding]; other site 765874002924 Substrate Binding Site II [chemical binding]; other site 765874002925 Substrate Binding Site I [chemical binding]; other site 765874002926 argininosuccinate lyase; Provisional; Region: PRK00855 765874002927 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 765874002928 active sites [active] 765874002929 tetramer interface [polypeptide binding]; other site 765874002930 Uncharacterized conserved protein [Function unknown]; Region: COG2835 765874002931 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 765874002932 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 765874002933 active site 765874002934 HIGH motif; other site 765874002935 dimer interface [polypeptide binding]; other site 765874002936 KMSKS motif; other site 765874002937 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765874002938 RNA binding surface [nucleotide binding]; other site 765874002939 transcription termination factor Rho; Provisional; Region: PRK12678 765874002940 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 765874002941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874002942 active site 765874002943 motif I; other site 765874002944 motif II; other site 765874002945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874002946 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 765874002947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765874002948 RNA binding surface [nucleotide binding]; other site 765874002949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874002950 S-adenosylmethionine binding site [chemical binding]; other site 765874002951 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 765874002952 ATP-NAD kinase; Region: NAD_kinase; pfam01513 765874002953 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 765874002954 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 765874002955 Walker A/P-loop; other site 765874002956 ATP binding site [chemical binding]; other site 765874002957 Q-loop/lid; other site 765874002958 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 765874002959 ABC transporter signature motif; other site 765874002960 Walker B; other site 765874002961 D-loop; other site 765874002962 H-loop/switch region; other site 765874002963 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 765874002964 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 765874002965 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 765874002966 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 765874002967 dimer interface [polypeptide binding]; other site 765874002968 ADP-ribose binding site [chemical binding]; other site 765874002969 active site 765874002970 nudix motif; other site 765874002971 metal binding site [ion binding]; metal-binding site 765874002972 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 765874002973 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 765874002974 active site 765874002975 Int/Topo IB signature motif; other site 765874002976 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 765874002977 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 765874002978 P-loop; other site 765874002979 Magnesium ion binding site [ion binding]; other site 765874002980 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 765874002981 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 765874002982 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 765874002983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874002984 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 765874002985 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765874002986 inhibitor-cofactor binding pocket; inhibition site 765874002987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874002988 catalytic residue [active] 765874002989 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 765874002990 AAA domain; Region: AAA_26; pfam13500 765874002991 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 765874002992 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 765874002993 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765874002994 RNA binding surface [nucleotide binding]; other site 765874002995 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 765874002996 active site 765874002997 cytidylate kinase; Provisional; Region: cmk; PRK00023 765874002998 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 765874002999 CMP-binding site; other site 765874003000 The sites determining sugar specificity; other site 765874003001 GTP-binding protein Der; Reviewed; Region: PRK03003 765874003002 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 765874003003 G1 box; other site 765874003004 GTP/Mg2+ binding site [chemical binding]; other site 765874003005 Switch I region; other site 765874003006 G2 box; other site 765874003007 Switch II region; other site 765874003008 G3 box; other site 765874003009 G4 box; other site 765874003010 G5 box; other site 765874003011 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 765874003012 G1 box; other site 765874003013 GTP/Mg2+ binding site [chemical binding]; other site 765874003014 Switch I region; other site 765874003015 G2 box; other site 765874003016 G3 box; other site 765874003017 Switch II region; other site 765874003018 G4 box; other site 765874003019 G5 box; other site 765874003020 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 765874003021 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 765874003022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874003023 S-adenosylmethionine binding site [chemical binding]; other site 765874003024 Predicted esterase [General function prediction only]; Region: COG0627 765874003025 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 765874003026 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 765874003027 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874003028 intersubunit interface [polypeptide binding]; other site 765874003029 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874003030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874003031 dimer interface [polypeptide binding]; other site 765874003032 ABC-ATPase subunit interface; other site 765874003033 putative PBP binding regions; other site 765874003034 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874003035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874003036 ABC-ATPase subunit interface; other site 765874003037 dimer interface [polypeptide binding]; other site 765874003038 putative PBP binding regions; other site 765874003039 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874003040 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874003041 Walker A/P-loop; other site 765874003042 ATP binding site [chemical binding]; other site 765874003043 Q-loop/lid; other site 765874003044 ABC transporter signature motif; other site 765874003045 Walker B; other site 765874003046 D-loop; other site 765874003047 H-loop/switch region; other site 765874003048 IucA / IucC family; Region: IucA_IucC; pfam04183 765874003049 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 765874003050 IucA / IucC family; Region: IucA_IucC; pfam04183 765874003051 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 765874003052 H+ Antiporter protein; Region: 2A0121; TIGR00900 765874003053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765874003054 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 765874003055 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 765874003056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 765874003057 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 765874003058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874003059 nucleotide binding region [chemical binding]; other site 765874003060 ATP-binding site [chemical binding]; other site 765874003061 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 765874003062 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765874003063 phosphopeptide binding site; other site 765874003064 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 765874003065 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 765874003066 DNA binding residues [nucleotide binding] 765874003067 Bifunctional nuclease; Region: DNase-RNase; pfam02577 765874003068 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 765874003069 DNA binding residues [nucleotide binding] 765874003070 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 765874003071 putative dimer interface [polypeptide binding]; other site 765874003072 Domain of unknown function DUF21; Region: DUF21; pfam01595 765874003073 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765874003074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765874003075 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765874003076 Domain of unknown function DUF21; Region: DUF21; pfam01595 765874003077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765874003078 Transporter associated domain; Region: CorC_HlyC; smart01091 765874003079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 765874003080 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 765874003081 ATP binding site [chemical binding]; other site 765874003082 putative Mg++ binding site [ion binding]; other site 765874003083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874003084 nucleotide binding region [chemical binding]; other site 765874003085 ATP-binding site [chemical binding]; other site 765874003086 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 765874003087 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 765874003088 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 765874003089 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 765874003090 CoenzymeA binding site [chemical binding]; other site 765874003091 subunit interaction site [polypeptide binding]; other site 765874003092 PHB binding site; other site 765874003093 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 765874003094 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 765874003095 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 765874003096 oligomer interface [polypeptide binding]; other site 765874003097 metal binding site [ion binding]; metal-binding site 765874003098 metal binding site [ion binding]; metal-binding site 765874003099 putative Cl binding site [ion binding]; other site 765874003100 basic sphincter; other site 765874003101 hydrophobic gate; other site 765874003102 periplasmic entrance; other site 765874003103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874003104 S-adenosylmethionine binding site [chemical binding]; other site 765874003105 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 765874003106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765874003107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765874003108 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 765874003109 metabolite-proton symporter; Region: 2A0106; TIGR00883 765874003110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874003111 putative substrate translocation pore; other site 765874003112 YceI-like domain; Region: YceI; pfam04264 765874003113 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 765874003114 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 765874003115 Ligand binding site; other site 765874003116 Putative Catalytic site; other site 765874003117 DXD motif; other site 765874003118 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 765874003119 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 765874003120 putative active site [active] 765874003121 catalytic triad [active] 765874003122 putative dimer interface [polypeptide binding]; other site 765874003123 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 765874003124 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 765874003125 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 765874003126 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 765874003127 precorrin-3B synthase; Region: CobG; TIGR02435 765874003128 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 765874003129 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 765874003130 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 765874003131 Precorrin-8X methylmutase; Region: CbiC; pfam02570 765874003132 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 765874003133 active site 765874003134 SAM binding site [chemical binding]; other site 765874003135 homodimer interface [polypeptide binding]; other site 765874003136 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 765874003137 active site 765874003138 SAM binding site [chemical binding]; other site 765874003139 homodimer interface [polypeptide binding]; other site 765874003140 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 765874003141 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 765874003142 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 765874003143 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 765874003144 active site 765874003145 SAM binding site [chemical binding]; other site 765874003146 homodimer interface [polypeptide binding]; other site 765874003147 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 765874003148 active site 765874003149 putative homodimer interface [polypeptide binding]; other site 765874003150 SAM binding site [chemical binding]; other site 765874003151 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 765874003152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874003153 S-adenosylmethionine binding site [chemical binding]; other site 765874003154 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 765874003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874003156 NAD(P) binding site [chemical binding]; other site 765874003157 active site 765874003158 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 765874003159 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 765874003160 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 765874003161 active site 765874003162 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 765874003163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874003164 ATP binding site [chemical binding]; other site 765874003165 putative Mg++ binding site [ion binding]; other site 765874003166 helicase superfamily c-terminal domain; Region: HELICc; smart00490 765874003167 nucleotide binding region [chemical binding]; other site 765874003168 ATP-binding site [chemical binding]; other site 765874003169 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 765874003170 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 765874003171 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 765874003172 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 765874003173 Predicted transcriptional regulator [Transcription]; Region: COG2378 765874003174 WYL domain; Region: WYL; pfam13280 765874003175 Predicted transcriptional regulator [Transcription]; Region: COG2378 765874003176 WYL domain; Region: WYL; pfam13280 765874003177 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 765874003178 Pup-like protein; Region: Pup; pfam05639 765874003179 Pup-ligase protein; Region: Pup_ligase; cl15463 765874003180 proteasome ATPase; Region: pup_AAA; TIGR03689 765874003181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874003182 Walker A motif; other site 765874003183 ATP binding site [chemical binding]; other site 765874003184 Walker B motif; other site 765874003185 arginine finger; other site 765874003186 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 765874003187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 765874003188 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 765874003189 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 765874003190 active site 765874003191 metal binding site [ion binding]; metal-binding site 765874003192 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 765874003193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 765874003194 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 765874003195 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 765874003196 Potassium binding sites [ion binding]; other site 765874003197 Cesium cation binding sites [ion binding]; other site 765874003198 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 765874003199 Aspartase; Region: Aspartase; cd01357 765874003200 active sites [active] 765874003201 tetramer interface [polypeptide binding]; other site 765874003202 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 765874003203 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 765874003204 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 765874003205 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 765874003206 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 765874003207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 765874003208 homodimer interface [polypeptide binding]; other site 765874003209 putative metal binding site [ion binding]; other site 765874003210 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 765874003211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874003212 motif II; other site 765874003213 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 765874003214 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 765874003215 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 765874003216 substrate binding pocket [chemical binding]; other site 765874003217 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 765874003218 B12 binding site [chemical binding]; other site 765874003219 cobalt ligand [ion binding]; other site 765874003220 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 765874003221 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 765874003222 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874003223 active site 765874003224 HIGH motif; other site 765874003225 nucleotide binding site [chemical binding]; other site 765874003226 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874003227 active site 765874003228 KMSKS motif; other site 765874003229 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765874003230 tRNA binding surface [nucleotide binding]; other site 765874003231 anticodon binding site; other site 765874003232 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 765874003233 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765874003234 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765874003235 active site 765874003236 catalytic tetrad [active] 765874003237 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 765874003238 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 765874003239 quinone interaction residues [chemical binding]; other site 765874003240 active site 765874003241 catalytic residues [active] 765874003242 FMN binding site [chemical binding]; other site 765874003243 substrate binding site [chemical binding]; other site 765874003244 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 765874003245 substrate binding site [chemical binding]; other site 765874003246 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 765874003247 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 765874003248 dimerization domain swap beta strand [polypeptide binding]; other site 765874003249 regulatory protein interface [polypeptide binding]; other site 765874003250 active site 765874003251 regulatory phosphorylation site [posttranslational modification]; other site 765874003252 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 765874003253 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 765874003254 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 765874003255 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765874003256 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874003257 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 765874003258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874003259 NAD(P) binding site [chemical binding]; other site 765874003260 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 765874003261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874003262 NAD(P) binding site [chemical binding]; other site 765874003263 active site 765874003264 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 765874003265 GTP/Mg2+ binding site [chemical binding]; other site 765874003266 G4 box; other site 765874003267 membrane ATPase/protein kinase; Provisional; Region: PRK09435 765874003268 G5 box; other site 765874003269 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 765874003270 Walker A; other site 765874003271 G1 box; other site 765874003272 Switch I region; other site 765874003273 G2 box; other site 765874003274 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 765874003275 G4 box; other site 765874003276 G5 box; other site 765874003277 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 765874003278 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 765874003279 active site 765874003280 substrate binding site [chemical binding]; other site 765874003281 coenzyme B12 binding site [chemical binding]; other site 765874003282 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 765874003283 B12 binding site [chemical binding]; other site 765874003284 cobalt ligand [ion binding]; other site 765874003285 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 765874003286 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 765874003287 heterodimer interface [polypeptide binding]; other site 765874003288 substrate interaction site [chemical binding]; other site 765874003289 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 765874003290 Uncharacterized conserved protein [Function unknown]; Region: COG0398 765874003291 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 765874003292 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 765874003293 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 765874003294 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 765874003295 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 765874003296 ferrochelatase; Reviewed; Region: hemH; PRK00035 765874003297 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 765874003298 C-terminal domain interface [polypeptide binding]; other site 765874003299 active site 765874003300 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 765874003301 active site 765874003302 N-terminal domain interface [polypeptide binding]; other site 765874003303 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 765874003304 NlpC/P60 family; Region: NLPC_P60; pfam00877 765874003305 pyruvate carboxylase subunit A; Validated; Region: PRK07178 765874003306 aconitate hydratase; Validated; Region: PRK09277 765874003307 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 765874003308 substrate binding site [chemical binding]; other site 765874003309 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 765874003310 ligand binding site [chemical binding]; other site 765874003311 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 765874003312 substrate binding site [chemical binding]; other site 765874003313 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 765874003314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874003315 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 765874003316 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 765874003317 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 765874003318 catalytic triad [active] 765874003319 conserved cys residue [active] 765874003320 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 765874003321 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 765874003322 AAA ATPase domain; Region: AAA_16; pfam13191 765874003323 AAA domain; Region: AAA_22; pfam13401 765874003324 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765874003325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874003326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874003327 Walker A/P-loop; other site 765874003328 ATP binding site [chemical binding]; other site 765874003329 Q-loop/lid; other site 765874003330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874003331 ABC transporter signature motif; other site 765874003332 Walker B; other site 765874003333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874003334 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 765874003335 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 765874003336 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 765874003337 trimerization site [polypeptide binding]; other site 765874003338 active site 765874003339 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 765874003340 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 765874003341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765874003342 catalytic residue [active] 765874003343 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 765874003344 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 765874003345 Walker A/P-loop; other site 765874003346 ATP binding site [chemical binding]; other site 765874003347 Q-loop/lid; other site 765874003348 ABC transporter signature motif; other site 765874003349 Walker B; other site 765874003350 D-loop; other site 765874003351 H-loop/switch region; other site 765874003352 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 765874003353 FeS assembly protein SufD; Region: sufD; TIGR01981 765874003354 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 765874003355 FeS assembly protein SufB; Region: sufB; TIGR01980 765874003356 Predicted transcriptional regulator [Transcription]; Region: COG2345 765874003357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 765874003358 putative DNA binding site [nucleotide binding]; other site 765874003359 putative Zn2+ binding site [ion binding]; other site 765874003360 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 765874003361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765874003362 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765874003363 Walker A/P-loop; other site 765874003364 ATP binding site [chemical binding]; other site 765874003365 Q-loop/lid; other site 765874003366 ABC transporter signature motif; other site 765874003367 Walker B; other site 765874003368 D-loop; other site 765874003369 H-loop/switch region; other site 765874003370 ABC-2 type transporter; Region: ABC2_membrane; cl17235 765874003371 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 765874003372 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 765874003373 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 765874003374 UbiA prenyltransferase family; Region: UbiA; pfam01040 765874003375 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 765874003376 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 765874003377 TPP-binding site [chemical binding]; other site 765874003378 dimer interface [polypeptide binding]; other site 765874003379 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765874003380 PYR/PP interface [polypeptide binding]; other site 765874003381 dimer interface [polypeptide binding]; other site 765874003382 TPP binding site [chemical binding]; other site 765874003383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765874003384 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 765874003385 putative active site [active] 765874003386 transaldolase; Provisional; Region: PRK03903 765874003387 catalytic residue [active] 765874003388 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 765874003389 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 765874003390 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 765874003391 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 765874003392 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 765874003393 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 765874003394 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 765874003395 putative active site [active] 765874003396 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 765874003397 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 765874003398 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 765874003399 triosephosphate isomerase; Provisional; Region: PRK14567 765874003400 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 765874003401 substrate binding site [chemical binding]; other site 765874003402 dimer interface [polypeptide binding]; other site 765874003403 catalytic triad [active] 765874003404 Phosphoglycerate kinase; Region: PGK; pfam00162 765874003405 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 765874003406 substrate binding site [chemical binding]; other site 765874003407 hinge regions; other site 765874003408 ADP binding site [chemical binding]; other site 765874003409 catalytic site [active] 765874003410 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 765874003411 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 765874003412 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 765874003413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 765874003414 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 765874003415 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 765874003416 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 765874003417 phosphate binding site [ion binding]; other site 765874003418 putative substrate binding pocket [chemical binding]; other site 765874003419 dimer interface [polypeptide binding]; other site 765874003420 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 765874003421 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 765874003422 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 765874003423 GIY-YIG motif/motif A; other site 765874003424 active site 765874003425 catalytic site [active] 765874003426 putative DNA binding site [nucleotide binding]; other site 765874003427 metal binding site [ion binding]; metal-binding site 765874003428 UvrB/uvrC motif; Region: UVR; pfam02151 765874003429 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 765874003430 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 765874003431 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 765874003432 homopentamer interface [polypeptide binding]; other site 765874003433 active site 765874003434 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 765874003435 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 765874003436 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 765874003437 dimerization interface [polypeptide binding]; other site 765874003438 active site 765874003439 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 765874003440 Lumazine binding domain; Region: Lum_binding; pfam00677 765874003441 Lumazine binding domain; Region: Lum_binding; pfam00677 765874003442 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 765874003443 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 765874003444 catalytic motif [active] 765874003445 Zn binding site [ion binding]; other site 765874003446 RibD C-terminal domain; Region: RibD_C; pfam01872 765874003447 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 765874003448 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 765874003449 substrate binding site [chemical binding]; other site 765874003450 hexamer interface [polypeptide binding]; other site 765874003451 metal binding site [ion binding]; metal-binding site 765874003452 16S rRNA methyltransferase B; Provisional; Region: PRK14902 765874003453 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 765874003454 putative RNA binding site [nucleotide binding]; other site 765874003455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874003456 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 765874003457 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 765874003458 putative active site [active] 765874003459 substrate binding site [chemical binding]; other site 765874003460 putative cosubstrate binding site; other site 765874003461 catalytic site [active] 765874003462 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 765874003463 substrate binding site [chemical binding]; other site 765874003464 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 765874003465 active site 765874003466 catalytic residues [active] 765874003467 metal binding site [ion binding]; metal-binding site 765874003468 primosome assembly protein PriA; Provisional; Region: PRK14873 765874003469 S-adenosylmethionine synthetase; Validated; Region: PRK05250 765874003470 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 765874003471 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 765874003472 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 765874003473 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 765874003474 Flavoprotein; Region: Flavoprotein; pfam02441 765874003475 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 765874003476 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 765874003477 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 765874003478 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 765874003479 catalytic site [active] 765874003480 G-X2-G-X-G-K; other site 765874003481 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 765874003482 active site 765874003483 dimer interface [polypeptide binding]; other site 765874003484 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 765874003485 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765874003486 ATP-grasp domain; Region: ATP-grasp_4; cl17255 765874003487 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 765874003488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765874003489 ATP-grasp domain; Region: ATP-grasp_4; cl17255 765874003490 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 765874003491 IMP binding site; other site 765874003492 dimer interface [polypeptide binding]; other site 765874003493 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 765874003494 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 765874003495 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 765874003496 catalytic site [active] 765874003497 subunit interface [polypeptide binding]; other site 765874003498 dihydroorotase; Validated; Region: pyrC; PRK09357 765874003499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 765874003500 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 765874003501 active site 765874003502 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 765874003503 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 765874003504 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 765874003505 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 765874003506 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874003507 active site 765874003508 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 765874003509 putative hydrophobic ligand binding site [chemical binding]; other site 765874003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874003511 TIGR01777 family protein; Region: yfcH 765874003512 NAD(P) binding site [chemical binding]; other site 765874003513 active site 765874003514 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 765874003515 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 765874003516 putative RNA binding site [nucleotide binding]; other site 765874003517 elongation factor P; Validated; Region: PRK00529 765874003518 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 765874003519 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 765874003520 RNA binding site [nucleotide binding]; other site 765874003521 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 765874003522 RNA binding site [nucleotide binding]; other site 765874003523 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 765874003524 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 765874003525 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 765874003526 active site 765874003527 Dehydroquinase class II; Region: DHquinase_II; pfam01220 765874003528 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 765874003529 trimer interface [polypeptide binding]; other site 765874003530 active site 765874003531 dimer interface [polypeptide binding]; other site 765874003532 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 765874003533 active site 765874003534 dimer interface [polypeptide binding]; other site 765874003535 metal binding site [ion binding]; metal-binding site 765874003536 shikimate kinase; Reviewed; Region: aroK; PRK00131 765874003537 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 765874003538 ADP binding site [chemical binding]; other site 765874003539 magnesium binding site [ion binding]; other site 765874003540 putative shikimate binding site; other site 765874003541 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 765874003542 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 765874003543 Tetramer interface [polypeptide binding]; other site 765874003544 active site 765874003545 FMN-binding site [chemical binding]; other site 765874003546 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 765874003547 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 765874003548 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 765874003549 shikimate binding site; other site 765874003550 NAD(P) binding site [chemical binding]; other site 765874003551 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 765874003552 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 765874003553 dimerization interface [polypeptide binding]; other site 765874003554 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 765874003555 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 765874003556 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 765874003557 motif 1; other site 765874003558 active site 765874003559 motif 2; other site 765874003560 motif 3; other site 765874003561 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 765874003562 DHHA1 domain; Region: DHHA1; pfam02272 765874003563 recombination factor protein RarA; Reviewed; Region: PRK13342 765874003564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874003565 Walker A motif; other site 765874003566 ATP binding site [chemical binding]; other site 765874003567 Walker B motif; other site 765874003568 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 765874003569 Phosphotransferase enzyme family; Region: APH; pfam01636 765874003570 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 765874003571 substrate binding site [chemical binding]; other site 765874003572 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 765874003573 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 765874003574 dimer interface [polypeptide binding]; other site 765874003575 anticodon binding site; other site 765874003576 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 765874003577 homodimer interface [polypeptide binding]; other site 765874003578 motif 1; other site 765874003579 active site 765874003580 motif 2; other site 765874003581 GAD domain; Region: GAD; pfam02938 765874003582 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765874003583 active site 765874003584 motif 3; other site 765874003585 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 765874003586 DEAD-like helicases superfamily; Region: DEXDc; smart00487 765874003587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874003588 ATP binding site [chemical binding]; other site 765874003589 putative Mg++ binding site [ion binding]; other site 765874003590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874003591 nucleotide binding region [chemical binding]; other site 765874003592 ATP-binding site [chemical binding]; other site 765874003593 Predicted membrane protein [Function unknown]; Region: COG1511 765874003594 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 765874003595 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 765874003596 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 765874003597 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 765874003598 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 765874003599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874003600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874003601 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 765874003602 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 765874003603 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 765874003604 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 765874003605 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 765874003606 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 765874003607 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 765874003608 putative active site [active] 765874003609 putative catalytic site [active] 765874003610 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 765874003611 CoA-transferase family III; Region: CoA_transf_3; pfam02515 765874003612 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 765874003613 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 765874003614 dimer interface [polypeptide binding]; other site 765874003615 motif 1; other site 765874003616 active site 765874003617 motif 2; other site 765874003618 motif 3; other site 765874003619 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 765874003620 anticodon binding site; other site 765874003621 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 765874003622 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 765874003623 dimer interface [polypeptide binding]; other site 765874003624 catalytic triad [active] 765874003625 peroxidatic and resolving cysteines [active] 765874003626 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 765874003627 active site 765874003628 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 765874003629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765874003630 Zn2+ binding site [ion binding]; other site 765874003631 Mg2+ binding site [ion binding]; other site 765874003632 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 765874003633 synthetase active site [active] 765874003634 NTP binding site [chemical binding]; other site 765874003635 metal binding site [ion binding]; metal-binding site 765874003636 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 765874003637 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 765874003638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874003639 active site 765874003640 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 765874003641 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 765874003642 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 765874003643 Protein export membrane protein; Region: SecD_SecF; pfam02355 765874003644 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 765874003645 Protein export membrane protein; Region: SecD_SecF; cl14618 765874003646 Preprotein translocase subunit; Region: YajC; pfam02699 765874003647 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 765874003648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874003649 Walker A motif; other site 765874003650 ATP binding site [chemical binding]; other site 765874003651 Walker B motif; other site 765874003652 arginine finger; other site 765874003653 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 765874003654 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 765874003655 RuvA N terminal domain; Region: RuvA_N; pfam01330 765874003656 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 765874003657 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 765874003658 active site 765874003659 putative DNA-binding cleft [nucleotide binding]; other site 765874003660 dimer interface [polypeptide binding]; other site 765874003661 hypothetical protein; Validated; Region: PRK00110 765874003662 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 765874003663 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 765874003664 active site 765874003665 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 765874003666 catalytic triad [active] 765874003667 dimer interface [polypeptide binding]; other site 765874003668 Protein of unknown function (DUF998); Region: DUF998; pfam06197 765874003669 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 765874003670 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 765874003671 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 765874003672 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765874003673 catalytic residue [active] 765874003674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765874003675 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 765874003676 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 765874003677 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 765874003678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 765874003679 putative acyl-acceptor binding pocket; other site 765874003680 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 765874003681 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 765874003682 nucleotide binding site/active site [active] 765874003683 HIT family signature motif; other site 765874003684 catalytic residue [active] 765874003685 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 765874003686 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 765874003687 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 765874003688 active site 765874003689 dimer interface [polypeptide binding]; other site 765874003690 motif 1; other site 765874003691 motif 2; other site 765874003692 motif 3; other site 765874003693 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 765874003694 anticodon binding site; other site 765874003695 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 765874003696 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 765874003697 Protein of unknown function (DUF461); Region: DUF461; pfam04314 765874003698 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 765874003699 hypothetical protein; Provisional; Region: PRK14059 765874003700 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 765874003701 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 765874003702 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 765874003703 SelR domain; Region: SelR; pfam01641 765874003704 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 765874003705 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 765874003706 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 765874003707 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 765874003708 catalytic site [active] 765874003709 putative active site [active] 765874003710 putative substrate binding site [chemical binding]; other site 765874003711 HRDC domain; Region: HRDC; pfam00570 765874003712 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 765874003713 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 765874003714 TPP-binding site; other site 765874003715 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765874003716 PYR/PP interface [polypeptide binding]; other site 765874003717 dimer interface [polypeptide binding]; other site 765874003718 TPP binding site [chemical binding]; other site 765874003719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765874003720 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 765874003721 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 765874003722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874003723 S-adenosylmethionine binding site [chemical binding]; other site 765874003724 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 765874003725 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 765874003726 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765874003727 trimer interface [polypeptide binding]; other site 765874003728 active site 765874003729 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 765874003730 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 765874003731 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 765874003732 active site 765874003733 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 765874003734 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 765874003735 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 765874003736 nucleotide binding site [chemical binding]; other site 765874003737 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 765874003738 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 765874003739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874003740 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 765874003741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874003742 DNA binding residues [nucleotide binding] 765874003743 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 765874003744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874003745 ATP binding site [chemical binding]; other site 765874003746 putative Mg++ binding site [ion binding]; other site 765874003747 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 765874003748 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 765874003749 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 765874003750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874003751 S-adenosylmethionine binding site [chemical binding]; other site 765874003752 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 765874003753 putative active site [active] 765874003754 dimerization interface [polypeptide binding]; other site 765874003755 putative tRNAtyr binding site [nucleotide binding]; other site 765874003756 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 765874003757 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 765874003758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874003759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 765874003760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874003761 DNA binding residues [nucleotide binding] 765874003762 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 765874003763 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 765874003764 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 765874003765 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 765874003766 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 765874003767 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 765874003768 NAD binding site [chemical binding]; other site 765874003769 homodimer interface [polypeptide binding]; other site 765874003770 active site 765874003771 substrate binding site [chemical binding]; other site 765874003772 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 765874003773 PAC2 family; Region: PAC2; pfam09754 765874003774 potential frameshift: common BLAST hit: gi|38234003|ref|NP_939770.1| helicase 765874003775 DEAD-like helicases superfamily; Region: DEXDc; smart00487 765874003776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874003777 ATP binding site [chemical binding]; other site 765874003778 putative Mg++ binding site [ion binding]; other site 765874003779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874003780 nucleotide binding region [chemical binding]; other site 765874003781 ATP-binding site [chemical binding]; other site 765874003782 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 765874003783 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 765874003784 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 765874003785 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 765874003786 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 765874003787 decamer (pentamer of dimers) interface [polypeptide binding]; other site 765874003788 catalytic triad [active] 765874003789 dimer interface [polypeptide binding]; other site 765874003790 peroxidatic and resolving cysteines [active] 765874003791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 765874003792 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 765874003793 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 765874003794 dimerization interface [polypeptide binding]; other site 765874003795 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 765874003796 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 765874003797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874003798 ATP binding site [chemical binding]; other site 765874003799 putative Mg++ binding site [ion binding]; other site 765874003800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765874003801 nucleotide binding region [chemical binding]; other site 765874003802 ATP-binding site [chemical binding]; other site 765874003803 Helicase associated domain (HA2); Region: HA2; pfam04408 765874003804 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 765874003805 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 765874003806 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 765874003807 ATP cone domain; Region: ATP-cone; pfam03477 765874003808 LexA repressor; Validated; Region: PRK00215 765874003809 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 765874003810 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 765874003811 Catalytic site [active] 765874003812 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 765874003813 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 765874003814 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 765874003815 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 765874003816 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 765874003817 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 765874003818 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 765874003819 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 765874003820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 765874003821 DNA-binding site [nucleotide binding]; DNA binding site 765874003822 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 765874003823 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 765874003824 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 765874003825 putative substrate binding site [chemical binding]; other site 765874003826 putative ATP binding site [chemical binding]; other site 765874003827 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765874003828 active site 765874003829 phosphorylation site [posttranslational modification] 765874003830 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 765874003831 active site 765874003832 P-loop; other site 765874003833 phosphorylation site [posttranslational modification] 765874003834 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 765874003835 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 765874003836 dimerization domain swap beta strand [polypeptide binding]; other site 765874003837 regulatory protein interface [polypeptide binding]; other site 765874003838 active site 765874003839 regulatory phosphorylation site [posttranslational modification]; other site 765874003840 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 765874003841 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 765874003842 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 765874003843 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 765874003844 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 765874003845 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 765874003846 GTPases [General function prediction only]; Region: HflX; COG2262 765874003847 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 765874003848 HflX GTPase family; Region: HflX; cd01878 765874003849 G1 box; other site 765874003850 GTP/Mg2+ binding site [chemical binding]; other site 765874003851 Switch I region; other site 765874003852 G2 box; other site 765874003853 G3 box; other site 765874003854 Switch II region; other site 765874003855 G4 box; other site 765874003856 G5 box; other site 765874003857 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 765874003858 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 765874003859 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 765874003860 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 765874003861 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 765874003862 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 765874003863 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 765874003864 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 765874003865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 765874003866 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 765874003867 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765874003868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874003869 FeS/SAM binding site; other site 765874003870 recombination regulator RecX; Reviewed; Region: recX; PRK00117 765874003871 recombinase A; Provisional; Region: recA; PRK09354 765874003872 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 765874003873 hexamer interface [polypeptide binding]; other site 765874003874 Walker A motif; other site 765874003875 ATP binding site [chemical binding]; other site 765874003876 Walker B motif; other site 765874003877 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 765874003878 BioY family; Region: BioY; pfam02632 765874003879 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 765874003880 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 765874003881 Walker A/P-loop; other site 765874003882 ATP binding site [chemical binding]; other site 765874003883 Q-loop/lid; other site 765874003884 ABC transporter signature motif; other site 765874003885 Walker B; other site 765874003886 D-loop; other site 765874003887 H-loop/switch region; other site 765874003888 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 765874003889 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 765874003890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765874003891 sequence-specific DNA binding site [nucleotide binding]; other site 765874003892 salt bridge; other site 765874003893 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 765874003894 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 765874003895 YCII-related domain; Region: YCII; cl00999 765874003896 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 765874003897 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 765874003898 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 765874003899 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 765874003900 TIGR03085 family protein; Region: TIGR03085 765874003901 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 765874003902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 765874003903 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 765874003904 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 765874003905 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 765874003906 dimer interface [polypeptide binding]; other site 765874003907 active site 765874003908 catalytic residue [active] 765874003909 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 765874003910 dihydrodipicolinate reductase; Provisional; Region: PRK00048 765874003911 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 765874003912 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 765874003913 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 765874003914 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 765874003915 oligomer interface [polypeptide binding]; other site 765874003916 RNA binding site [nucleotide binding]; other site 765874003917 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 765874003918 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 765874003919 RNase E interface [polypeptide binding]; other site 765874003920 trimer interface [polypeptide binding]; other site 765874003921 active site 765874003922 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 765874003923 putative nucleic acid binding region [nucleotide binding]; other site 765874003924 G-X-X-G motif; other site 765874003925 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 765874003926 RNA binding site [nucleotide binding]; other site 765874003927 domain interface; other site 765874003928 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 765874003929 16S/18S rRNA binding site [nucleotide binding]; other site 765874003930 S13e-L30e interaction site [polypeptide binding]; other site 765874003931 25S rRNA binding site [nucleotide binding]; other site 765874003932 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 765874003933 active site 765874003934 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 765874003935 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 765874003936 active site 765874003937 Riboflavin kinase; Region: Flavokinase; smart00904 765874003938 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 765874003939 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 765874003940 RNA binding site [nucleotide binding]; other site 765874003941 active site 765874003942 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 765874003943 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 765874003944 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 765874003945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765874003946 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765874003947 active site 765874003948 metal binding site [ion binding]; metal-binding site 765874003949 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 765874003950 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 765874003951 DHH family; Region: DHH; pfam01368 765874003952 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 765874003953 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 765874003954 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 765874003955 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 765874003956 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 765874003957 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 765874003958 G1 box; other site 765874003959 putative GEF interaction site [polypeptide binding]; other site 765874003960 GTP/Mg2+ binding site [chemical binding]; other site 765874003961 Switch I region; other site 765874003962 G2 box; other site 765874003963 G3 box; other site 765874003964 Switch II region; other site 765874003965 G4 box; other site 765874003966 G5 box; other site 765874003967 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 765874003968 Translation-initiation factor 2; Region: IF-2; pfam11987 765874003969 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 765874003970 Protein of unknown function (DUF448); Region: DUF448; pfam04296 765874003971 putative RNA binding cleft [nucleotide binding]; other site 765874003972 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 765874003973 NusA N-terminal domain; Region: NusA_N; pfam08529 765874003974 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 765874003975 RNA binding site [nucleotide binding]; other site 765874003976 homodimer interface [polypeptide binding]; other site 765874003977 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 765874003978 G-X-X-G motif; other site 765874003979 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 765874003980 G-X-X-G motif; other site 765874003981 ribosome maturation protein RimP; Reviewed; Region: PRK00092 765874003982 Sm and related proteins; Region: Sm_like; cl00259 765874003983 prolyl-tRNA synthetase; Provisional; Region: PRK09194 765874003984 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765874003985 motif 1; other site 765874003986 dimer interface [polypeptide binding]; other site 765874003987 active site 765874003988 motif 2; other site 765874003989 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 765874003990 putative deacylase active site [active] 765874003991 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765874003992 active site 765874003993 motif 3; other site 765874003994 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 765874003995 anticodon binding site; other site 765874003996 hypothetical protein; Validated; Region: PRK02101 765874003997 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 765874003998 active site 765874003999 SAM binding site [chemical binding]; other site 765874004000 homodimer interface [polypeptide binding]; other site 765874004001 hypothetical protein; Validated; Region: PRK00029 765874004002 Uncharacterized conserved protein [Function unknown]; Region: COG0397 765874004003 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 765874004004 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 765874004005 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 765874004006 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 765874004007 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765874004008 DNA binding site [nucleotide binding] 765874004009 active site 765874004010 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 765874004011 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 765874004012 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 765874004013 catalytic triad [active] 765874004014 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 765874004015 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 765874004016 homodimer interface [polypeptide binding]; other site 765874004017 Walker A motif; other site 765874004018 ATP binding site [chemical binding]; other site 765874004019 hydroxycobalamin binding site [chemical binding]; other site 765874004020 Walker B motif; other site 765874004021 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 765874004022 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 765874004023 metal ion-dependent adhesion site (MIDAS); other site 765874004024 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 765874004025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874004026 Walker A motif; other site 765874004027 ATP binding site [chemical binding]; other site 765874004028 Walker B motif; other site 765874004029 arginine finger; other site 765874004030 malate:quinone oxidoreductase; Validated; Region: PRK05257 765874004031 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 765874004032 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 765874004033 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 765874004034 mycothione reductase; Reviewed; Region: PRK07846 765874004035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765874004036 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765874004037 cobyric acid synthase; Provisional; Region: PRK00784 765874004038 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 765874004039 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 765874004040 catalytic triad [active] 765874004041 methionine aminopeptidase; Provisional; Region: PRK12318 765874004042 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 765874004043 active site 765874004044 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 765874004045 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 765874004046 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 765874004047 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 765874004048 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 765874004049 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 765874004050 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 765874004051 active site 765874004052 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 765874004053 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 765874004054 putative substrate binding region [chemical binding]; other site 765874004055 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 765874004056 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 765874004057 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 765874004058 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 765874004059 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 765874004060 potential frameshift: common BLAST hit: gi|38234081|ref|NP_939848.1| ribosomal RNA large subunit methyltransferase N 765874004061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874004062 FeS/SAM binding site; other site 765874004063 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 765874004064 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 765874004065 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 765874004066 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 765874004067 ribosome recycling factor; Reviewed; Region: frr; PRK00083 765874004068 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 765874004069 hinge region; other site 765874004070 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 765874004071 putative nucleotide binding site [chemical binding]; other site 765874004072 uridine monophosphate binding site [chemical binding]; other site 765874004073 homohexameric interface [polypeptide binding]; other site 765874004074 elongation factor Ts; Provisional; Region: tsf; PRK09377 765874004075 UBA/TS-N domain; Region: UBA; pfam00627 765874004076 Elongation factor TS; Region: EF_TS; pfam00889 765874004077 Elongation factor TS; Region: EF_TS; pfam00889 765874004078 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 765874004079 rRNA interaction site [nucleotide binding]; other site 765874004080 S8 interaction site; other site 765874004081 putative laminin-1 binding site; other site 765874004082 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 765874004083 Peptidase family M23; Region: Peptidase_M23; pfam01551 765874004084 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 765874004085 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765874004086 active site 765874004087 DNA binding site [nucleotide binding] 765874004088 Int/Topo IB signature motif; other site 765874004089 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 765874004090 DNA protecting protein DprA; Region: dprA; TIGR00732 765874004091 hypothetical protein; Reviewed; Region: PRK12497 765874004092 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 765874004093 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 765874004094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874004095 Walker A motif; other site 765874004096 ATP binding site [chemical binding]; other site 765874004097 Walker B motif; other site 765874004098 arginine finger; other site 765874004099 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 765874004100 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 765874004101 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 765874004102 RNA/DNA hybrid binding site [nucleotide binding]; other site 765874004103 active site 765874004104 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 765874004105 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765874004106 Catalytic site [active] 765874004107 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765874004108 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 765874004109 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 765874004110 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 765874004111 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 765874004112 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765874004113 RNA binding site [nucleotide binding]; other site 765874004114 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 765874004115 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 765874004116 active site 765874004117 P-loop; other site 765874004118 phosphorylation site [posttranslational modification] 765874004119 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 765874004120 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765874004121 active site 765874004122 phosphorylation site [posttranslational modification] 765874004123 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 765874004124 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 765874004125 RimM N-terminal domain; Region: RimM; pfam01782 765874004126 PRC-barrel domain; Region: PRC; pfam05239 765874004127 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 765874004128 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 765874004129 signal recognition particle protein; Provisional; Region: PRK10867 765874004130 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 765874004131 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765874004132 P loop; other site 765874004133 GTP binding site [chemical binding]; other site 765874004134 Signal peptide binding domain; Region: SRP_SPB; pfam02978 765874004135 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 765874004136 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 765874004137 metal binding triad; other site 765874004138 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 765874004139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765874004140 Zn2+ binding site [ion binding]; other site 765874004141 Mg2+ binding site [ion binding]; other site 765874004142 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 765874004143 Nitrogen regulatory protein P-II; Region: P-II; smart00938 765874004144 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 765874004145 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 765874004146 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 765874004147 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765874004148 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 765874004149 Walker A/P-loop; other site 765874004150 ATP binding site [chemical binding]; other site 765874004151 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 765874004152 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 765874004153 ABC transporter signature motif; other site 765874004154 Walker B; other site 765874004155 D-loop; other site 765874004156 H-loop/switch region; other site 765874004157 Acylphosphatase; Region: Acylphosphatase; cl00551 765874004158 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765874004159 amino acid carrier protein; Region: agcS; TIGR00835 765874004160 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 765874004161 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 765874004162 DNA binding site [nucleotide binding] 765874004163 catalytic residue [active] 765874004164 H2TH interface [polypeptide binding]; other site 765874004165 putative catalytic residues [active] 765874004166 turnover-facilitating residue; other site 765874004167 intercalation triad [nucleotide binding]; other site 765874004168 8OG recognition residue [nucleotide binding]; other site 765874004169 putative reading head residues; other site 765874004170 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 765874004171 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 765874004172 ribonuclease III; Reviewed; Region: rnc; PRK00102 765874004173 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 765874004174 dimerization interface [polypeptide binding]; other site 765874004175 active site 765874004176 metal binding site [ion binding]; metal-binding site 765874004177 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 765874004178 dsRNA binding site [nucleotide binding]; other site 765874004179 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 765874004180 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 765874004181 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 765874004182 RibD C-terminal domain; Region: RibD_C; cl17279 765874004183 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 765874004184 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 765874004185 hexamer interface [polypeptide binding]; other site 765874004186 ligand binding site [chemical binding]; other site 765874004187 putative active site [active] 765874004188 NAD(P) binding site [chemical binding]; other site 765874004189 glutamate dehydrogenase; Provisional; Region: PRK09414 765874004190 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 765874004191 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 765874004192 NAD(P) binding site [chemical binding]; other site 765874004193 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 765874004194 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 765874004195 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765874004196 nucleotide binding site/active site [active] 765874004197 HIT family signature motif; other site 765874004198 catalytic residue [active] 765874004199 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 765874004200 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 765874004201 metal binding site [ion binding]; metal-binding site 765874004202 putative dimer interface [polypeptide binding]; other site 765874004203 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 765874004204 homodimer interface [polypeptide binding]; other site 765874004205 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 765874004206 active site pocket [active] 765874004207 Electron transfer DM13; Region: DM13; pfam10517 765874004208 pyruvate kinase; Provisional; Region: PRK06247 765874004209 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 765874004210 domain interfaces; other site 765874004211 active site 765874004212 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 765874004213 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 765874004214 active site 765874004215 ribulose/triose binding site [chemical binding]; other site 765874004216 phosphate binding site [ion binding]; other site 765874004217 substrate (anthranilate) binding pocket [chemical binding]; other site 765874004218 product (indole) binding pocket [chemical binding]; other site 765874004219 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 765874004220 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 765874004221 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 765874004222 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 765874004223 substrate binding site [chemical binding]; other site 765874004224 glutamase interaction surface [polypeptide binding]; other site 765874004225 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 765874004226 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 765874004227 active site 765874004228 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 765874004229 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 765874004230 catalytic residues [active] 765874004231 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 765874004232 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 765874004233 putative active site [active] 765874004234 oxyanion strand; other site 765874004235 catalytic triad [active] 765874004236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874004237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874004238 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 765874004239 putative active site pocket [active] 765874004240 4-fold oligomerization interface [polypeptide binding]; other site 765874004241 metal binding residues [ion binding]; metal-binding site 765874004242 3-fold/trimer interface [polypeptide binding]; other site 765874004243 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 765874004244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874004245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874004246 homodimer interface [polypeptide binding]; other site 765874004247 catalytic residue [active] 765874004248 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 765874004249 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 765874004250 NAD binding site [chemical binding]; other site 765874004251 dimerization interface [polypeptide binding]; other site 765874004252 product binding site; other site 765874004253 substrate binding site [chemical binding]; other site 765874004254 zinc binding site [ion binding]; other site 765874004255 catalytic residues [active] 765874004256 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 765874004257 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 765874004258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874004259 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 765874004260 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 765874004261 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 765874004262 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 765874004263 active site 765874004264 catalytic site [active] 765874004265 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 765874004266 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 765874004267 active site 765874004268 catalytic site [active] 765874004269 substrate binding site [chemical binding]; other site 765874004270 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 765874004271 Dimer interface [polypeptide binding]; other site 765874004272 BRCT sequence motif; other site 765874004273 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 765874004274 synthetase active site [active] 765874004275 NTP binding site [chemical binding]; other site 765874004276 metal binding site [ion binding]; metal-binding site 765874004277 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765874004278 RNA binding surface [nucleotide binding]; other site 765874004279 Uncharacterized conserved protein [Function unknown]; Region: COG1739 765874004280 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 765874004281 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 765874004282 threonine dehydratase; Validated; Region: PRK08639 765874004283 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 765874004284 tetramer interface [polypeptide binding]; other site 765874004285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874004286 catalytic residue [active] 765874004287 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 765874004288 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 765874004289 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 765874004290 active site 765874004291 PHP Thumb interface [polypeptide binding]; other site 765874004292 metal binding site [ion binding]; metal-binding site 765874004293 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 765874004294 generic binding surface I; other site 765874004295 generic binding surface II; other site 765874004296 Predicted permeases [General function prediction only]; Region: RarD; COG2962 765874004297 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765874004298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 765874004299 RNA binding surface [nucleotide binding]; other site 765874004300 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 765874004301 active site 765874004302 lipoprotein signal peptidase; Provisional; Region: PRK14764 765874004303 lipoprotein signal peptidase; Provisional; Region: PRK14787 765874004304 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 765874004305 active site 765874004306 homotetramer interface [polypeptide binding]; other site 765874004307 homodimer interface [polypeptide binding]; other site 765874004308 DNA polymerase IV; Provisional; Region: PRK03348 765874004309 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 765874004310 active site 765874004311 DNA binding site [nucleotide binding] 765874004312 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 765874004313 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765874004314 HIGH motif; other site 765874004315 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765874004316 active site 765874004317 KMSKS motif; other site 765874004318 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 765874004319 tRNA binding surface [nucleotide binding]; other site 765874004320 anticodon binding site; other site 765874004321 DivIVA protein; Region: DivIVA; pfam05103 765874004322 DivIVA domain; Region: DivI1A_domain; TIGR03544 765874004323 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 765874004324 Protein of unknown function (DUF552); Region: DUF552; cl00775 765874004325 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 765874004326 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 765874004327 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 765874004328 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 765874004329 nucleotide binding site [chemical binding]; other site 765874004330 SulA interaction site; other site 765874004331 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 765874004332 Cell division protein FtsQ; Region: FtsQ; pfam03799 765874004333 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 765874004334 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765874004335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874004336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765874004337 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 765874004338 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 765874004339 homodimer interface [polypeptide binding]; other site 765874004340 active site 765874004341 cell division protein FtsW; Region: ftsW; TIGR02614 765874004342 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 765874004343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874004344 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 765874004345 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 765874004346 Mg++ binding site [ion binding]; other site 765874004347 putative catalytic motif [active] 765874004348 putative substrate binding site [chemical binding]; other site 765874004349 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 765874004350 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765874004351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874004352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765874004353 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 765874004354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765874004355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874004356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765874004357 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 765874004358 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765874004359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 765874004360 MraW methylase family; Region: Methyltransf_5; cl17771 765874004361 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 765874004362 cell division protein MraZ; Reviewed; Region: PRK00326 765874004363 MraZ protein; Region: MraZ; pfam02381 765874004364 MraZ protein; Region: MraZ; pfam02381 765874004365 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 765874004366 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765874004367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 765874004368 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 765874004369 FAD binding site [chemical binding]; other site 765874004370 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 765874004371 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765874004372 substrate binding pocket [chemical binding]; other site 765874004373 chain length determination region; other site 765874004374 substrate-Mg2+ binding site; other site 765874004375 catalytic residues [active] 765874004376 aspartate-rich region 1; other site 765874004377 active site lid residues [active] 765874004378 aspartate-rich region 2; other site 765874004379 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 765874004380 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765874004381 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765874004382 active site 765874004383 ATP binding site [chemical binding]; other site 765874004384 substrate binding site [chemical binding]; other site 765874004385 activation loop (A-loop); other site 765874004386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 765874004387 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874004388 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874004389 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874004390 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 765874004391 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 765874004392 Predicted membrane protein [Function unknown]; Region: COG4763 765874004393 Acyltransferase family; Region: Acyl_transf_3; pfam01757 765874004394 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 765874004395 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765874004396 putative acyl-acceptor binding pocket; other site 765874004397 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 765874004398 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 765874004399 nucleotide binding site [chemical binding]; other site 765874004400 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 765874004401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765874004402 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 765874004403 NlpC/P60 family; Region: NLPC_P60; pfam00877 765874004404 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 765874004405 NlpC/P60 family; Region: NLPC_P60; pfam00877 765874004406 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 765874004407 heme bH binding site [chemical binding]; other site 765874004408 intrachain domain interface; other site 765874004409 heme bL binding site [chemical binding]; other site 765874004410 interchain domain interface [polypeptide binding]; other site 765874004411 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 765874004412 Qo binding site; other site 765874004413 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 765874004414 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 765874004415 iron-sulfur cluster [ion binding]; other site 765874004416 [2Fe-2S] cluster binding site [ion binding]; other site 765874004417 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 765874004418 Cytochrome c; Region: Cytochrom_C; pfam00034 765874004419 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 765874004420 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 765874004421 Subunit I/III interface [polypeptide binding]; other site 765874004422 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 765874004423 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 765874004424 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 765874004425 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 765874004426 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 765874004427 active site 765874004428 dimer interface [polypeptide binding]; other site 765874004429 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 765874004430 Ligand Binding Site [chemical binding]; other site 765874004431 Molecular Tunnel; other site 765874004432 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 765874004433 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 765874004434 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 765874004435 homotrimer interface [polypeptide binding]; other site 765874004436 Walker A motif; other site 765874004437 GTP binding site [chemical binding]; other site 765874004438 Walker B motif; other site 765874004439 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 765874004440 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 765874004441 putative dimer interface [polypeptide binding]; other site 765874004442 active site pocket [active] 765874004443 putative cataytic base [active] 765874004444 cobalamin synthase; Reviewed; Region: cobS; PRK00235 765874004445 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 765874004446 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 765874004447 homodimer interface [polypeptide binding]; other site 765874004448 substrate-cofactor binding pocket; other site 765874004449 catalytic residue [active] 765874004450 multifunctional aminopeptidase A; Provisional; Region: PRK00913 765874004451 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 765874004452 interface (dimer of trimers) [polypeptide binding]; other site 765874004453 Substrate-binding/catalytic site; other site 765874004454 Zn-binding sites [ion binding]; other site 765874004455 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 765874004456 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765874004457 E3 interaction surface; other site 765874004458 lipoyl attachment site [posttranslational modification]; other site 765874004459 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765874004460 E3 interaction surface; other site 765874004461 lipoyl attachment site [posttranslational modification]; other site 765874004462 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765874004463 E3 interaction surface; other site 765874004464 lipoyl attachment site [posttranslational modification]; other site 765874004465 e3 binding domain; Region: E3_binding; pfam02817 765874004466 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 765874004467 glycine dehydrogenase; Provisional; Region: PRK05367 765874004468 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 765874004469 tetramer interface [polypeptide binding]; other site 765874004470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874004471 catalytic residue [active] 765874004472 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 765874004473 tetramer interface [polypeptide binding]; other site 765874004474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874004475 catalytic residue [active] 765874004476 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 765874004477 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 765874004478 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 765874004479 lipoyl attachment site [posttranslational modification]; other site 765874004480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 765874004481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765874004482 active site 765874004483 lipoate-protein ligase B; Provisional; Region: PRK14345 765874004484 lipoyl synthase; Provisional; Region: PRK05481 765874004485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874004486 FeS/SAM binding site; other site 765874004487 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 765874004488 RDD family; Region: RDD; pfam06271 765874004489 glutamine synthetase, type I; Region: GlnA; TIGR00653 765874004490 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 765874004491 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 765874004492 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 765874004493 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 765874004494 potential frameshift: common BLAST hit: gi|50843072|ref|YP_056299.1| phage-associated protein 765874004495 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 765874004496 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 765874004497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874004498 DNA binding residues [nucleotide binding] 765874004499 AAA domain; Region: AAA_23; pfam13476 765874004500 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 765874004501 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 765874004502 DNA methylase; Region: N6_N4_Mtase; pfam01555 765874004503 DNA methylase; Region: N6_N4_Mtase; cl17433 765874004504 potential frameshift: common BLAST hit: gi|222150485|ref|YP_002559638.1| type III restriction-modification system restriction endonuclease 765874004505 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 765874004506 ATP binding site [chemical binding]; other site 765874004507 potential frameshift: common BLAST hit: gi|269797513|ref|YP_003311413.1| type III restriction protein res subunit 765874004508 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 765874004509 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 765874004510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874004511 AAA domain; Region: AAA_21; pfam13304 765874004512 Walker A/P-loop; other site 765874004513 ATP binding site [chemical binding]; other site 765874004514 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 765874004515 putative active site [active] 765874004516 putative metal-binding site [ion binding]; other site 765874004517 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 765874004518 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 765874004519 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 765874004520 HsdM N-terminal domain; Region: HsdM_N; pfam12161 765874004521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765874004522 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765874004523 Walker A/P-loop; other site 765874004524 ATP binding site [chemical binding]; other site 765874004525 Q-loop/lid; other site 765874004526 ABC transporter signature motif; other site 765874004527 Walker B; other site 765874004528 D-loop; other site 765874004529 H-loop/switch region; other site 765874004530 Htaa; Region: HtaA; pfam04213 765874004531 Htaa; Region: HtaA; pfam04213 765874004532 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 765874004533 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 765874004534 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 765874004535 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 765874004536 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 765874004537 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 765874004538 active site 765874004539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 765874004540 Predicted permease [General function prediction only]; Region: COG2056 765874004541 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 765874004542 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 765874004543 nudix motif; other site 765874004544 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 765874004545 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 765874004546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874004547 catalytic residue [active] 765874004548 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 765874004549 active site 765874004550 catalytic site [active] 765874004551 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 765874004552 heme binding pocket [chemical binding]; other site 765874004553 heme ligand [chemical binding]; other site 765874004554 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 765874004555 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 765874004556 metal binding triad; other site 765874004557 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 765874004558 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 765874004559 metal binding triad; other site 765874004560 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 765874004561 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 765874004562 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 765874004563 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 765874004564 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 765874004565 putative active site; other site 765874004566 putative metal binding residues [ion binding]; other site 765874004567 signature motif; other site 765874004568 putative triphosphate binding site [ion binding]; other site 765874004569 CHAD domain; Region: CHAD; pfam05235 765874004570 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 765874004571 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 765874004572 RNB domain; Region: RNB; pfam00773 765874004573 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 765874004574 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 765874004575 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 765874004576 RNA/DNA hybrid binding site [nucleotide binding]; other site 765874004577 active site 765874004578 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874004579 catalytic core [active] 765874004580 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 765874004581 Putative zinc ribbon domain; Region: DUF164; pfam02591 765874004582 Uncharacterized conserved protein [Function unknown]; Region: COG0327 765874004583 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 765874004584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 765874004585 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 765874004586 hypothetical protein; Provisional; Region: PRK07908 765874004587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874004588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874004589 homodimer interface [polypeptide binding]; other site 765874004590 catalytic residue [active] 765874004591 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 765874004592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874004593 motif II; other site 765874004594 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 765874004595 Low molecular weight phosphatase family; Region: LMWPc; cl00105 765874004596 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 765874004597 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 765874004598 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 765874004599 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 765874004600 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 765874004601 dimer interface [polypeptide binding]; other site 765874004602 TPP-binding site [chemical binding]; other site 765874004603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 765874004604 Serine hydrolase; Region: Ser_hydrolase; cl17834 765874004605 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765874004606 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 765874004607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874004608 active site 765874004609 motif I; other site 765874004610 motif II; other site 765874004611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874004612 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 765874004613 Beta-lactamase; Region: Beta-lactamase; pfam00144 765874004614 Predicted membrane protein [Function unknown]; Region: COG2860 765874004615 UPF0126 domain; Region: UPF0126; pfam03458 765874004616 UPF0126 domain; Region: UPF0126; pfam03458 765874004617 DNA primase; Validated; Region: dnaG; PRK05667 765874004618 CHC2 zinc finger; Region: zf-CHC2; pfam01807 765874004619 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 765874004620 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 765874004621 active site 765874004622 metal binding site [ion binding]; metal-binding site 765874004623 interdomain interaction site; other site 765874004624 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 765874004625 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 765874004626 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 765874004627 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 765874004628 glutaminase active site [active] 765874004629 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 765874004630 dimer interface [polypeptide binding]; other site 765874004631 active site 765874004632 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 765874004633 dimer interface [polypeptide binding]; other site 765874004634 active site 765874004635 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 765874004636 active site 765874004637 barstar interaction site; other site 765874004638 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 765874004639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765874004640 Zn2+ binding site [ion binding]; other site 765874004641 Mg2+ binding site [ion binding]; other site 765874004642 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 765874004643 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 765874004644 putative active site [active] 765874004645 Repair protein; Region: Repair_PSII; pfam04536 765874004646 glycyl-tRNA synthetase; Provisional; Region: PRK04173 765874004647 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765874004648 motif 1; other site 765874004649 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 765874004650 active site 765874004651 motif 2; other site 765874004652 motif 3; other site 765874004653 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 765874004654 anticodon binding site; other site 765874004655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 765874004656 putative DNA binding site [nucleotide binding]; other site 765874004657 putative Zn2+ binding site [ion binding]; other site 765874004658 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 765874004659 metal binding site 2 [ion binding]; metal-binding site 765874004660 putative DNA binding helix; other site 765874004661 metal binding site 1 [ion binding]; metal-binding site 765874004662 dimer interface [polypeptide binding]; other site 765874004663 structural Zn2+ binding site [ion binding]; other site 765874004664 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 765874004665 diiron binding motif [ion binding]; other site 765874004666 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 765874004667 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 765874004668 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 765874004669 catalytic residue [active] 765874004670 putative FPP diphosphate binding site; other site 765874004671 putative FPP binding hydrophobic cleft; other site 765874004672 dimer interface [polypeptide binding]; other site 765874004673 putative IPP diphosphate binding site; other site 765874004674 Recombination protein O N terminal; Region: RecO_N; pfam11967 765874004675 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 765874004676 Recombination protein O C terminal; Region: RecO_C; pfam02565 765874004677 GTPase Era; Reviewed; Region: era; PRK00089 765874004678 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 765874004679 G1 box; other site 765874004680 GTP/Mg2+ binding site [chemical binding]; other site 765874004681 Switch I region; other site 765874004682 G2 box; other site 765874004683 Switch II region; other site 765874004684 G3 box; other site 765874004685 G4 box; other site 765874004686 G5 box; other site 765874004687 KH domain; Region: KH_2; pfam07650 765874004688 pyridoxamine kinase; Validated; Region: PRK05756 765874004689 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 765874004690 dimer interface [polypeptide binding]; other site 765874004691 pyridoxal binding site [chemical binding]; other site 765874004692 ATP binding site [chemical binding]; other site 765874004693 Domain of unknown function DUF21; Region: DUF21; pfam01595 765874004694 FOG: CBS domain [General function prediction only]; Region: COG0517 765874004695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765874004696 Transporter associated domain; Region: CorC_HlyC; cl08393 765874004697 metal-binding heat shock protein; Provisional; Region: PRK00016 765874004698 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 765874004699 PhoH-like protein; Region: PhoH; pfam02562 765874004700 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 765874004701 RNA methyltransferase, RsmE family; Region: TIGR00046 765874004702 chaperone protein DnaJ; Provisional; Region: PRK14278 765874004703 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765874004704 HSP70 interaction site [polypeptide binding]; other site 765874004705 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 765874004706 Zn binding sites [ion binding]; other site 765874004707 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 765874004708 dimer interface [polypeptide binding]; other site 765874004709 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 765874004710 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 765874004711 coproporphyrinogen III oxidase; Validated; Region: PRK05628 765874004712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765874004713 FeS/SAM binding site; other site 765874004714 HemN C-terminal domain; Region: HemN_C; pfam06969 765874004715 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 765874004716 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 765874004717 acyl-activating enzyme (AAE) consensus motif; other site 765874004718 putative AMP binding site [chemical binding]; other site 765874004719 putative active site [active] 765874004720 putative CoA binding site [chemical binding]; other site 765874004721 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 765874004722 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 765874004723 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 765874004724 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 765874004725 active site 765874004726 Zn binding site [ion binding]; other site 765874004727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 765874004728 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 765874004729 substrate binding pocket [chemical binding]; other site 765874004730 catalytic triad [active] 765874004731 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 765874004732 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 765874004733 active site 765874004734 metal binding site [ion binding]; metal-binding site 765874004735 nudix motif; other site 765874004736 potential frameshift: common BLAST hit: gi|38234306|ref|NP_940073.1| ABC transporter ATP-binding protein 765874004737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765874004738 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765874004739 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 765874004740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874004741 Walker A/P-loop; other site 765874004742 ATP binding site [chemical binding]; other site 765874004743 Q-loop/lid; other site 765874004744 ABC transporter signature motif; other site 765874004745 Walker B; other site 765874004746 D-loop; other site 765874004747 H-loop/switch region; other site 765874004748 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 765874004749 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 765874004750 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 765874004751 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 765874004752 active site 765874004753 BCCT family transporter; Region: BCCT; pfam02028 765874004754 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 765874004755 Predicted permeases [General function prediction only]; Region: COG0679 765874004756 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 765874004757 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 765874004758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874004759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874004760 dimer interface [polypeptide binding]; other site 765874004761 conserved gate region; other site 765874004762 putative PBP binding loops; other site 765874004763 ABC-ATPase subunit interface; other site 765874004764 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 765874004765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874004766 dimer interface [polypeptide binding]; other site 765874004767 conserved gate region; other site 765874004768 putative PBP binding loops; other site 765874004769 ABC-ATPase subunit interface; other site 765874004770 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 765874004771 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874004772 Walker A/P-loop; other site 765874004773 ATP binding site [chemical binding]; other site 765874004774 Q-loop/lid; other site 765874004775 ABC transporter signature motif; other site 765874004776 Walker B; other site 765874004777 D-loop; other site 765874004778 H-loop/switch region; other site 765874004779 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874004780 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874004781 Walker A/P-loop; other site 765874004782 ATP binding site [chemical binding]; other site 765874004783 Q-loop/lid; other site 765874004784 ABC transporter signature motif; other site 765874004785 Walker B; other site 765874004786 D-loop; other site 765874004787 H-loop/switch region; other site 765874004788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874004789 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 765874004790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 765874004791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765874004792 catalytic residue [active] 765874004793 Sulphur transport; Region: Sulf_transp; pfam04143 765874004794 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 765874004795 CPxP motif; other site 765874004796 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874004797 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 765874004798 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 765874004799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 765874004800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 765874004801 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 765874004802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874004803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874004804 putative substrate translocation pore; other site 765874004805 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 765874004806 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 765874004807 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874004808 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 765874004809 Walker A/P-loop; other site 765874004810 ATP binding site [chemical binding]; other site 765874004811 Q-loop/lid; other site 765874004812 ABC transporter signature motif; other site 765874004813 Walker B; other site 765874004814 D-loop; other site 765874004815 H-loop/switch region; other site 765874004816 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 765874004817 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874004818 Walker A/P-loop; other site 765874004819 ATP binding site [chemical binding]; other site 765874004820 Q-loop/lid; other site 765874004821 ABC transporter signature motif; other site 765874004822 Walker B; other site 765874004823 D-loop; other site 765874004824 H-loop/switch region; other site 765874004825 GTP-binding protein LepA; Provisional; Region: PRK05433 765874004826 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 765874004827 G1 box; other site 765874004828 putative GEF interaction site [polypeptide binding]; other site 765874004829 GTP/Mg2+ binding site [chemical binding]; other site 765874004830 Switch I region; other site 765874004831 G2 box; other site 765874004832 G3 box; other site 765874004833 Switch II region; other site 765874004834 G4 box; other site 765874004835 G5 box; other site 765874004836 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 765874004837 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 765874004838 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 765874004839 PemK-like protein; Region: PemK; pfam02452 765874004840 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 765874004841 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 765874004842 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765874004843 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765874004844 hypothetical protein; Validated; Region: PRK05629 765874004845 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 765874004846 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 765874004847 Competence protein; Region: Competence; pfam03772 765874004848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 765874004849 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 765874004850 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874004851 catalytic core [active] 765874004852 Oligomerisation domain; Region: Oligomerisation; pfam02410 765874004853 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 765874004854 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 765874004855 active site 765874004856 (T/H)XGH motif; other site 765874004857 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 765874004858 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 765874004859 putative catalytic cysteine [active] 765874004860 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 765874004861 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 765874004862 putative ligand binding site [chemical binding]; other site 765874004863 putative NAD binding site [chemical binding]; other site 765874004864 catalytic site [active] 765874004865 Protein of unknown function (DUF454); Region: DUF454; cl01063 765874004866 Predicted permease [General function prediction only]; Region: COG2985 765874004867 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 765874004868 TrkA-C domain; Region: TrkA_C; pfam02080 765874004869 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 765874004870 gamma-glutamyl kinase; Provisional; Region: PRK05429 765874004871 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 765874004872 nucleotide binding site [chemical binding]; other site 765874004873 homotetrameric interface [polypeptide binding]; other site 765874004874 putative phosphate binding site [ion binding]; other site 765874004875 putative allosteric binding site; other site 765874004876 PUA domain; Region: PUA; pfam01472 765874004877 GTPase CgtA; Reviewed; Region: obgE; PRK12296 765874004878 GTP1/OBG; Region: GTP1_OBG; pfam01018 765874004879 Obg GTPase; Region: Obg; cd01898 765874004880 G1 box; other site 765874004881 GTP/Mg2+ binding site [chemical binding]; other site 765874004882 Switch I region; other site 765874004883 G2 box; other site 765874004884 G3 box; other site 765874004885 Switch II region; other site 765874004886 G4 box; other site 765874004887 G5 box; other site 765874004888 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 765874004889 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 765874004890 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 765874004891 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 765874004892 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 765874004893 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 765874004894 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 765874004895 homodimer interface [polypeptide binding]; other site 765874004896 oligonucleotide binding site [chemical binding]; other site 765874004897 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 765874004898 active site 765874004899 multimer interface [polypeptide binding]; other site 765874004900 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 765874004901 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 765874004902 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 765874004903 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 765874004904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874004905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765874004906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765874004907 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 765874004908 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874004909 active site 765874004910 HIGH motif; other site 765874004911 nucleotide binding site [chemical binding]; other site 765874004912 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 765874004913 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 765874004914 active site 765874004915 KMSKS motif; other site 765874004916 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 765874004917 tRNA binding surface [nucleotide binding]; other site 765874004918 anticodon binding site; other site 765874004919 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 765874004920 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 765874004921 malate dehydrogenase; Provisional; Region: PRK05442 765874004922 NAD(P) binding site [chemical binding]; other site 765874004923 dimer interface [polypeptide binding]; other site 765874004924 malate binding site [chemical binding]; other site 765874004925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874004926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874004927 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 765874004928 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 765874004929 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 765874004930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874004931 Walker A motif; other site 765874004932 ATP binding site [chemical binding]; other site 765874004933 Walker B motif; other site 765874004934 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 765874004935 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 765874004936 Glutamine amidotransferase class-I; Region: GATase; pfam00117 765874004937 glutamine binding [chemical binding]; other site 765874004938 catalytic triad [active] 765874004939 hypothetical protein; Validated; Region: PRK09070 765874004940 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 765874004941 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 765874004942 Aminotransferase class IV; Region: Aminotran_4; pfam01063 765874004943 substrate-cofactor binding pocket; other site 765874004944 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 765874004945 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765874004946 oligomer interface [polypeptide binding]; other site 765874004947 active site residues [active] 765874004948 Clp protease; Region: CLP_protease; pfam00574 765874004949 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765874004950 oligomer interface [polypeptide binding]; other site 765874004951 active site residues [active] 765874004952 trigger factor; Provisional; Region: tig; PRK01490 765874004953 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765874004954 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 765874004955 Pirin-related protein [General function prediction only]; Region: COG1741 765874004956 Pirin; Region: Pirin; pfam02678 765874004957 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 765874004958 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 765874004959 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 765874004960 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 765874004961 catalytic residues [active] 765874004962 potential frameshift: common BLAST hit: gi|38234369|ref|NP_940136.1| aminopeptidase 765874004963 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 765874004964 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 765874004965 Zn binding site [ion binding]; other site 765874004966 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 765874004967 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 765874004968 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765874004969 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 765874004970 apolar tunnel; other site 765874004971 heme binding site [chemical binding]; other site 765874004972 dimerization interface [polypeptide binding]; other site 765874004973 Protein of unknown function, DUF606; Region: DUF606; pfam04657 765874004974 Protein of unknown function, DUF606; Region: DUF606; pfam04657 765874004975 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 765874004976 active site 765874004977 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 765874004978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874004979 Walker A/P-loop; other site 765874004980 ATP binding site [chemical binding]; other site 765874004981 Q-loop/lid; other site 765874004982 ABC transporter signature motif; other site 765874004983 Walker B; other site 765874004984 D-loop; other site 765874004985 H-loop/switch region; other site 765874004986 ABC transporter; Region: ABC_tran_2; pfam12848 765874004987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765874004988 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 765874004989 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765874004990 dimer interface [polypeptide binding]; other site 765874004991 ssDNA binding site [nucleotide binding]; other site 765874004992 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765874004993 YcaO-like family; Region: YcaO; pfam02624 765874004994 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 765874004995 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 765874004996 FMN binding site [chemical binding]; other site 765874004997 dimer interface [polypeptide binding]; other site 765874004998 Nitroreductase family; Region: Nitroreductase; pfam00881 765874004999 dimer interface [polypeptide binding]; other site 765874005000 SpaB C-terminal domain; Region: SpaB_C; pfam14028 765874005001 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 765874005002 YcaO-like family; Region: YcaO; pfam02624 765874005003 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 765874005004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765874005005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765874005006 Walker A/P-loop; other site 765874005007 ATP binding site [chemical binding]; other site 765874005008 Q-loop/lid; other site 765874005009 ABC transporter signature motif; other site 765874005010 Walker B; other site 765874005011 D-loop; other site 765874005012 H-loop/switch region; other site 765874005013 Copper resistance protein D; Region: CopD; pfam05425 765874005014 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 765874005015 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 765874005016 Carbon starvation protein CstA; Region: CstA; pfam02554 765874005017 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 765874005018 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 765874005019 active site 765874005020 catalytic triad [active] 765874005021 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 765874005022 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 765874005023 NADP binding site [chemical binding]; other site 765874005024 dimer interface [polypeptide binding]; other site 765874005025 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 765874005026 classical (c) SDRs; Region: SDR_c; cd05233 765874005027 NAD(P) binding site [chemical binding]; other site 765874005028 active site 765874005029 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 765874005030 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 765874005031 catalytic site [active] 765874005032 putative active site [active] 765874005033 putative substrate binding site [chemical binding]; other site 765874005034 dimer interface [polypeptide binding]; other site 765874005035 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 765874005036 N-acetylneuraminate lyase; Provisional; Region: PRK04147 765874005037 inhibitor site; inhibition site 765874005038 active site 765874005039 dimer interface [polypeptide binding]; other site 765874005040 catalytic residue [active] 765874005041 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 765874005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 765874005043 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 765874005044 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 765874005045 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 765874005046 Prostaglandin dehydrogenases; Region: PGDH; cd05288 765874005047 NAD(P) binding site [chemical binding]; other site 765874005048 substrate binding site [chemical binding]; other site 765874005049 dimer interface [polypeptide binding]; other site 765874005050 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 765874005051 Isochorismatase family; Region: Isochorismatase; pfam00857 765874005052 catalytic triad [active] 765874005053 metal binding site [ion binding]; metal-binding site 765874005054 conserved cis-peptide bond; other site 765874005055 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 765874005056 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 765874005057 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 765874005058 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 765874005059 catalytic triad [active] 765874005060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874005061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874005062 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 765874005063 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 765874005064 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 765874005065 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 765874005066 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 765874005067 phosphate binding site [ion binding]; other site 765874005068 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 765874005069 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 765874005070 active site 2 [active] 765874005071 active site 1 [active] 765874005072 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 765874005073 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 765874005074 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 765874005075 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 765874005076 putative NAD(P) binding site [chemical binding]; other site 765874005077 active site 765874005078 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 765874005079 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 765874005080 active site 765874005081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 765874005082 Histidine kinase; Region: HisKA_3; pfam07730 765874005083 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 765874005084 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765874005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874005086 active site 765874005087 phosphorylation site [posttranslational modification] 765874005088 intermolecular recognition site; other site 765874005089 dimerization interface [polypeptide binding]; other site 765874005090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765874005091 DNA binding residues [nucleotide binding] 765874005092 dimerization interface [polypeptide binding]; other site 765874005093 Protein of unknown function (DUF418); Region: DUF418; pfam04235 765874005094 CAAX protease self-immunity; Region: Abi; pfam02517 765874005095 Glucitol operon activator protein (GutM); Region: GutM; cl01890 765874005096 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 765874005097 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 765874005098 active site 765874005099 dimerization interface [polypeptide binding]; other site 765874005100 ribonuclease PH; Reviewed; Region: rph; PRK00173 765874005101 Ribonuclease PH; Region: RNase_PH_bact; cd11362 765874005102 hexamer interface [polypeptide binding]; other site 765874005103 active site 765874005104 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 765874005105 glutamate racemase; Provisional; Region: PRK00865 765874005106 Rhomboid family; Region: Rhomboid; pfam01694 765874005107 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 765874005108 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 765874005109 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 765874005110 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 765874005111 active site 765874005112 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 765874005113 DEAD/DEAH box helicase; Region: DEAD; pfam00270 765874005114 ATP binding site [chemical binding]; other site 765874005115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765874005116 putative Mg++ binding site [ion binding]; other site 765874005117 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 765874005118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765874005119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765874005120 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 765874005121 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 765874005122 phosphoserine phosphatase SerB; Region: serB; TIGR00338 765874005123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874005124 motif II; other site 765874005125 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 765874005126 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 765874005127 D-pathway; other site 765874005128 Putative ubiquinol binding site [chemical binding]; other site 765874005129 Low-spin heme (heme b) binding site [chemical binding]; other site 765874005130 Putative water exit pathway; other site 765874005131 Binuclear center (heme o3/CuB) [ion binding]; other site 765874005132 K-pathway; other site 765874005133 Putative proton exit pathway; other site 765874005134 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 765874005135 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 765874005136 dimer interface [polypeptide binding]; other site 765874005137 putative radical transfer pathway; other site 765874005138 diiron center [ion binding]; other site 765874005139 tyrosyl radical; other site 765874005140 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 765874005141 Ferritin-like domain; Region: Ferritin; pfam00210 765874005142 ferroxidase diiron center [ion binding]; other site 765874005143 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 765874005144 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 765874005145 Class I ribonucleotide reductase; Region: RNR_I; cd01679 765874005146 active site 765874005147 dimer interface [polypeptide binding]; other site 765874005148 catalytic residues [active] 765874005149 effector binding site; other site 765874005150 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 765874005151 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 765874005152 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 765874005153 catalytic residues [active] 765874005154 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 765874005155 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 765874005156 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 765874005157 homodimer interface [polypeptide binding]; other site 765874005158 NAD binding pocket [chemical binding]; other site 765874005159 ATP binding pocket [chemical binding]; other site 765874005160 Mg binding site [ion binding]; other site 765874005161 active-site loop [active] 765874005162 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 765874005163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 765874005164 dimerization interface [polypeptide binding]; other site 765874005165 putative DNA binding site [nucleotide binding]; other site 765874005166 putative Zn2+ binding site [ion binding]; other site 765874005167 potential frameshift: common BLAST hit: gi|297625704|ref|YP_003687467.1| Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase 765874005168 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765874005169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765874005170 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765874005171 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765874005172 Thioredoxin; Region: Thioredoxin_4; cl17273 765874005173 Predicted membrane protein [Function unknown]; Region: COG2259 765874005174 phosphoglucomutase; Validated; Region: PRK07564 765874005175 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 765874005176 active site 765874005177 substrate binding site [chemical binding]; other site 765874005178 metal binding site [ion binding]; metal-binding site 765874005179 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 765874005180 CrcB-like protein; Region: CRCB; pfam02537 765874005181 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765874005182 FtsX-like permease family; Region: FtsX; pfam02687 765874005183 FtsX-like permease family; Region: FtsX; pfam02687 765874005184 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765874005185 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765874005186 Walker A/P-loop; other site 765874005187 ATP binding site [chemical binding]; other site 765874005188 Q-loop/lid; other site 765874005189 ABC transporter signature motif; other site 765874005190 Walker B; other site 765874005191 D-loop; other site 765874005192 H-loop/switch region; other site 765874005193 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 765874005194 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 765874005195 hinge; other site 765874005196 active site 765874005197 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 765874005198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765874005199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765874005200 DNA binding residues [nucleotide binding] 765874005201 dimerization interface [polypeptide binding]; other site 765874005202 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 765874005203 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 765874005204 dimer interface [polypeptide binding]; other site 765874005205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874005206 catalytic residue [active] 765874005207 serine O-acetyltransferase; Region: cysE; TIGR01172 765874005208 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 765874005209 trimer interface [polypeptide binding]; other site 765874005210 active site 765874005211 substrate binding site [chemical binding]; other site 765874005212 CoA binding site [chemical binding]; other site 765874005213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874005214 Coenzyme A binding pocket [chemical binding]; other site 765874005215 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 765874005216 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 765874005217 putative active site [active] 765874005218 metal binding site [ion binding]; metal-binding site 765874005219 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 765874005220 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 765874005221 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 765874005222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765874005223 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 765874005224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874005225 Walker A/P-loop; other site 765874005226 ATP binding site [chemical binding]; other site 765874005227 Q-loop/lid; other site 765874005228 ABC transporter signature motif; other site 765874005229 Walker B; other site 765874005230 D-loop; other site 765874005231 H-loop/switch region; other site 765874005232 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 765874005233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874005234 Walker A/P-loop; other site 765874005235 ATP binding site [chemical binding]; other site 765874005236 Q-loop/lid; other site 765874005237 ABC transporter signature motif; other site 765874005238 Walker B; other site 765874005239 D-loop; other site 765874005240 H-loop/switch region; other site 765874005241 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 765874005242 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 765874005243 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 765874005244 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 765874005245 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 765874005246 FMN binding site [chemical binding]; other site 765874005247 active site 765874005248 catalytic residues [active] 765874005249 substrate binding site [chemical binding]; other site 765874005250 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 765874005251 PhoU domain; Region: PhoU; pfam01895 765874005252 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 765874005253 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 765874005254 Walker A/P-loop; other site 765874005255 ATP binding site [chemical binding]; other site 765874005256 Q-loop/lid; other site 765874005257 ABC transporter signature motif; other site 765874005258 Walker B; other site 765874005259 D-loop; other site 765874005260 H-loop/switch region; other site 765874005261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 765874005262 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 765874005263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874005264 dimer interface [polypeptide binding]; other site 765874005265 conserved gate region; other site 765874005266 putative PBP binding loops; other site 765874005267 ABC-ATPase subunit interface; other site 765874005268 PBP superfamily domain; Region: PBP_like_2; cl17296 765874005269 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 765874005270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874005271 Coenzyme A binding pocket [chemical binding]; other site 765874005272 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765874005273 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 765874005274 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 765874005275 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 765874005276 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 765874005277 heme-binding site [chemical binding]; other site 765874005278 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 765874005279 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 765874005280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874005281 catalytic residue [active] 765874005282 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 765874005283 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 765874005284 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 765874005285 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 765874005286 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 765874005287 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 765874005288 dimerization interface [polypeptide binding]; other site 765874005289 putative ATP binding site [chemical binding]; other site 765874005290 amidophosphoribosyltransferase; Provisional; Region: PRK07847 765874005291 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 765874005292 active site 765874005293 tetramer interface [polypeptide binding]; other site 765874005294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874005295 active site 765874005296 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 765874005297 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 765874005298 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 765874005299 dimer interface [polypeptide binding]; other site 765874005300 putative radical transfer pathway; other site 765874005301 diiron center [ion binding]; other site 765874005302 tyrosyl radical; other site 765874005303 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 765874005304 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 765874005305 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 765874005306 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 765874005307 dimerization interface [polypeptide binding]; other site 765874005308 ATP binding site [chemical binding]; other site 765874005309 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 765874005310 dimerization interface [polypeptide binding]; other site 765874005311 ATP binding site [chemical binding]; other site 765874005312 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 765874005313 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 765874005314 putative active site [active] 765874005315 catalytic triad [active] 765874005316 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 765874005317 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 765874005318 catalytic residues [active] 765874005319 dimer interface [polypeptide binding]; other site 765874005320 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 765874005321 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 765874005322 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 765874005323 ATP binding site [chemical binding]; other site 765874005324 active site 765874005325 substrate binding site [chemical binding]; other site 765874005326 adenylosuccinate lyase; Region: purB; TIGR00928 765874005327 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 765874005328 tetramer interface [polypeptide binding]; other site 765874005329 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 765874005330 TrkA-N domain; Region: TrkA_N; pfam02254 765874005331 TrkA-C domain; Region: TrkA_C; pfam02080 765874005332 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 765874005333 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 765874005334 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 765874005335 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 765874005336 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 765874005337 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 765874005338 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 765874005339 nucleotide binding site/active site [active] 765874005340 HIT family signature motif; other site 765874005341 catalytic residue [active] 765874005342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765874005343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 765874005344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765874005345 dimerization interface [polypeptide binding]; other site 765874005346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765874005347 dimer interface [polypeptide binding]; other site 765874005348 phosphorylation site [posttranslational modification] 765874005349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874005350 ATP binding site [chemical binding]; other site 765874005351 Mg2+ binding site [ion binding]; other site 765874005352 G-X-G motif; other site 765874005353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765874005354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874005355 active site 765874005356 phosphorylation site [posttranslational modification] 765874005357 intermolecular recognition site; other site 765874005358 dimerization interface [polypeptide binding]; other site 765874005359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765874005360 DNA binding site [nucleotide binding] 765874005361 potential frameshift: common BLAST hit: gi|62391450|ref|YP_226852.1| major facilitator superfamily permease 765874005362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874005363 putative substrate translocation pore; other site 765874005364 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 765874005365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874005366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874005367 Predicted esterase [General function prediction only]; Region: COG0627 765874005368 S-formylglutathione hydrolase; Region: PLN02442 765874005369 xanthine permease; Region: pbuX; TIGR03173 765874005370 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 765874005371 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 765874005372 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 765874005373 putative active site [active] 765874005374 pyruvate dehydrogenase; Provisional; Region: PRK06546 765874005375 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 765874005376 PYR/PP interface [polypeptide binding]; other site 765874005377 tetramer interface [polypeptide binding]; other site 765874005378 dimer interface [polypeptide binding]; other site 765874005379 TPP binding site [chemical binding]; other site 765874005380 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 765874005381 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 765874005382 TPP-binding site [chemical binding]; other site 765874005383 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 765874005384 Uncharacterized conserved protein [Function unknown]; Region: COG3610 765874005385 Uncharacterized conserved protein [Function unknown]; Region: COG2966 765874005386 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 765874005387 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 765874005388 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 765874005389 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 765874005390 active site 765874005391 homotetramer interface [polypeptide binding]; other site 765874005392 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 765874005393 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 765874005394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 765874005395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 765874005396 DNA binding site [nucleotide binding] 765874005397 domain linker motif; other site 765874005398 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 765874005399 putative dimerization interface [polypeptide binding]; other site 765874005400 putative ligand binding site [chemical binding]; other site 765874005401 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 765874005402 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765874005403 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 765874005404 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765874005405 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 765874005406 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874005407 active site 765874005408 HIGH motif; other site 765874005409 nucleotide binding site [chemical binding]; other site 765874005410 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 765874005411 KMSKS motif; other site 765874005412 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765874005413 tRNA binding surface [nucleotide binding]; other site 765874005414 anticodon binding site; other site 765874005415 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 765874005416 homotrimer interaction site [polypeptide binding]; other site 765874005417 zinc binding site [ion binding]; other site 765874005418 CDP-binding sites; other site 765874005419 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 765874005420 substrate binding site; other site 765874005421 dimer interface; other site 765874005422 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 765874005423 flagellar hook protein FlgE, epsilon proteobacterial; Region: flgE_epsilon; TIGR02489 765874005424 DNA repair protein RadA; Provisional; Region: PRK11823 765874005425 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 765874005426 Walker A motif; other site 765874005427 ATP binding site [chemical binding]; other site 765874005428 Walker B motif; other site 765874005429 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 765874005430 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 765874005431 active site clefts [active] 765874005432 zinc binding site [ion binding]; other site 765874005433 dimer interface [polypeptide binding]; other site 765874005434 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765874005435 endonuclease III; Region: ENDO3c; smart00478 765874005436 minor groove reading motif; other site 765874005437 helix-hairpin-helix signature motif; other site 765874005438 substrate binding pocket [chemical binding]; other site 765874005439 active site 765874005440 Uncharacterized conserved protein [Function unknown]; Region: COG2966 765874005441 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 765874005442 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 765874005443 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 765874005444 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 765874005445 Clp amino terminal domain; Region: Clp_N; pfam02861 765874005446 Clp amino terminal domain; Region: Clp_N; pfam02861 765874005447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874005448 Walker A motif; other site 765874005449 ATP binding site [chemical binding]; other site 765874005450 Walker B motif; other site 765874005451 arginine finger; other site 765874005452 UvrB/uvrC motif; Region: UVR; pfam02151 765874005453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874005454 Walker A motif; other site 765874005455 ATP binding site [chemical binding]; other site 765874005456 Walker B motif; other site 765874005457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 765874005458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874005459 putative substrate translocation pore; other site 765874005460 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 765874005461 active site 765874005462 tetramer interface [polypeptide binding]; other site 765874005463 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 765874005464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 765874005465 CAAX protease self-immunity; Region: Abi; pfam02517 765874005466 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 765874005467 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 765874005468 dimer interface [polypeptide binding]; other site 765874005469 putative anticodon binding site; other site 765874005470 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765874005471 motif 1; other site 765874005472 dimer interface [polypeptide binding]; other site 765874005473 active site 765874005474 motif 2; other site 765874005475 motif 3; other site 765874005476 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 765874005477 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 765874005478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 765874005479 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765874005480 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 765874005481 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 765874005482 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765874005483 NAD(P) binding site [chemical binding]; other site 765874005484 catalytic residues [active] 765874005485 BCCT family transporter; Region: BCCT; cl00569 765874005486 choline dehydrogenase; Validated; Region: PRK02106 765874005487 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 765874005488 pantoate--beta-alanine ligase; Region: panC; TIGR00018 765874005489 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874005490 active site 765874005491 nucleotide binding site [chemical binding]; other site 765874005492 HIGH motif; other site 765874005493 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874005494 KMSKS motif; other site 765874005495 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 765874005496 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 765874005497 catalytic center binding site [active] 765874005498 ATP binding site [chemical binding]; other site 765874005499 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 765874005500 homooctamer interface [polypeptide binding]; other site 765874005501 active site 765874005502 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 765874005503 dihydropteroate synthase; Region: DHPS; TIGR01496 765874005504 substrate binding pocket [chemical binding]; other site 765874005505 dimer interface [polypeptide binding]; other site 765874005506 inhibitor binding site; inhibition site 765874005507 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 765874005508 GTP cyclohydrolase I; Provisional; Region: PLN03044 765874005509 homodecamer interface [polypeptide binding]; other site 765874005510 active site 765874005511 putative catalytic site residues [active] 765874005512 zinc binding site [ion binding]; other site 765874005513 GTP-CH-I/GFRP interaction surface; other site 765874005514 FtsH Extracellular; Region: FtsH_ext; pfam06480 765874005515 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 765874005516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874005517 Walker A motif; other site 765874005518 ATP binding site [chemical binding]; other site 765874005519 Walker B motif; other site 765874005520 arginine finger; other site 765874005521 Peptidase family M41; Region: Peptidase_M41; pfam01434 765874005522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874005523 active site 765874005524 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 765874005525 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 765874005526 Ligand Binding Site [chemical binding]; other site 765874005527 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 765874005528 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 765874005529 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 765874005530 dimer interface [polypeptide binding]; other site 765874005531 substrate binding site [chemical binding]; other site 765874005532 metal binding sites [ion binding]; metal-binding site 765874005533 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765874005534 active site residue [active] 765874005535 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 765874005536 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765874005537 Secretory lipase; Region: LIP; pfam03583 765874005538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 765874005539 MarR family; Region: MarR_2; pfam12802 765874005540 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765874005541 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 765874005542 acyl-activating enzyme (AAE) consensus motif; other site 765874005543 AMP binding site [chemical binding]; other site 765874005544 active site 765874005545 CoA binding site [chemical binding]; other site 765874005546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 765874005547 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 765874005548 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765874005549 putative trimer interface [polypeptide binding]; other site 765874005550 putative CoA binding site [chemical binding]; other site 765874005551 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765874005552 putative trimer interface [polypeptide binding]; other site 765874005553 putative CoA binding site [chemical binding]; other site 765874005554 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 765874005555 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765874005556 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765874005557 ring oligomerisation interface [polypeptide binding]; other site 765874005558 ATP/Mg binding site [chemical binding]; other site 765874005559 stacking interactions; other site 765874005560 hinge regions; other site 765874005561 hypothetical protein; Provisional; Region: PRK07907 765874005562 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 765874005563 active site 765874005564 metal binding site [ion binding]; metal-binding site 765874005565 dimer interface [polypeptide binding]; other site 765874005566 potential frameshift: common BLAST hit: gi|38232899|ref|NP_938666.1| surface-anchored membrane protein 765874005567 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 765874005568 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765874005569 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 765874005570 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 765874005571 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 765874005572 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 765874005573 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 765874005574 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765874005575 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 765874005576 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 765874005577 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 765874005578 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 765874005579 carboxylate-amine ligase; Provisional; Region: PRK13517 765874005580 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 765874005581 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 765874005582 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 765874005583 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 765874005584 active site 765874005585 catalytic residues [active] 765874005586 metal binding site [ion binding]; metal-binding site 765874005587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765874005588 Coenzyme A binding pocket [chemical binding]; other site 765874005589 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 765874005590 putative catalytic site [active] 765874005591 putative phosphate binding site [ion binding]; other site 765874005592 active site 765874005593 metal binding site A [ion binding]; metal-binding site 765874005594 DNA binding site [nucleotide binding] 765874005595 putative AP binding site [nucleotide binding]; other site 765874005596 putative metal binding site B [ion binding]; other site 765874005597 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 765874005598 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 765874005599 putative active site [active] 765874005600 catalytic site [active] 765874005601 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 765874005602 putative active site [active] 765874005603 catalytic site [active] 765874005604 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 765874005605 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765874005606 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 765874005607 Walker A/P-loop; other site 765874005608 ATP binding site [chemical binding]; other site 765874005609 Q-loop/lid; other site 765874005610 ABC transporter signature motif; other site 765874005611 Walker B; other site 765874005612 D-loop; other site 765874005613 H-loop/switch region; other site 765874005614 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 765874005615 nudix motif; other site 765874005616 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 765874005617 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765874005618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765874005619 substrate binding pocket [chemical binding]; other site 765874005620 membrane-bound complex binding site; other site 765874005621 hinge residues; other site 765874005622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765874005623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765874005624 active site 765874005625 ATP binding site [chemical binding]; other site 765874005626 substrate binding site [chemical binding]; other site 765874005627 activation loop (A-loop); other site 765874005628 propionate/acetate kinase; Provisional; Region: PRK12379 765874005629 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 765874005630 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 765874005631 ferredoxin-NADP+ reductase; Region: PLN02852 765874005632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765874005633 Coenzyme A binding pocket [chemical binding]; other site 765874005634 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 765874005635 active site 765874005636 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 765874005637 ATP-grasp domain; Region: ATP-grasp_4; cl17255 765874005638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874005639 active site 765874005640 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 765874005641 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 765874005642 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765874005643 catalytic residues [active] 765874005644 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 765874005645 ResB-like family; Region: ResB; pfam05140 765874005646 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 765874005647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765874005648 TPR motif; other site 765874005649 TPR repeat; Region: TPR_11; pfam13414 765874005650 binding surface 765874005651 Cytochrome c552; Region: Cytochrom_C552; pfam02335 765874005652 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 765874005653 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 765874005654 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 765874005655 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 765874005656 GDP-binding site [chemical binding]; other site 765874005657 ACT binding site; other site 765874005658 IMP binding site; other site 765874005659 Predicted membrane protein [Function unknown]; Region: COG4129 765874005660 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 765874005661 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 765874005662 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 765874005663 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765874005664 Walker A/P-loop; other site 765874005665 ATP binding site [chemical binding]; other site 765874005666 Q-loop/lid; other site 765874005667 ABC transporter signature motif; other site 765874005668 Walker B; other site 765874005669 D-loop; other site 765874005670 H-loop/switch region; other site 765874005671 Predicted transcriptional regulators [Transcription]; Region: COG1695 765874005672 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 765874005673 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 765874005674 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 765874005675 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 765874005676 Cna protein B-type domain; Region: Cna_B; pfam05738 765874005677 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 765874005678 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 765874005679 active site 765874005680 intersubunit interface [polypeptide binding]; other site 765874005681 zinc binding site [ion binding]; other site 765874005682 Na+ binding site [ion binding]; other site 765874005683 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 765874005684 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765874005685 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765874005686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765874005687 active site 765874005688 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 765874005689 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 765874005690 active site residue [active] 765874005691 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 765874005692 active site residue [active] 765874005693 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 765874005694 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 765874005695 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 765874005696 active site 765874005697 catalytic site [active] 765874005698 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 765874005699 Cna protein B-type domain; Region: Cna_B; pfam05738 765874005700 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 765874005701 active site 765874005702 catalytic site [active] 765874005703 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 765874005704 Clp amino terminal domain; Region: Clp_N; pfam02861 765874005705 Clp amino terminal domain; Region: Clp_N; pfam02861 765874005706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874005707 Walker A motif; other site 765874005708 ATP binding site [chemical binding]; other site 765874005709 Walker B motif; other site 765874005710 arginine finger; other site 765874005711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765874005712 Walker A motif; other site 765874005713 ATP binding site [chemical binding]; other site 765874005714 Walker B motif; other site 765874005715 arginine finger; other site 765874005716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 765874005717 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 765874005718 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765874005719 Walker A/P-loop; other site 765874005720 ATP binding site [chemical binding]; other site 765874005721 Q-loop/lid; other site 765874005722 ABC transporter signature motif; other site 765874005723 Walker B; other site 765874005724 D-loop; other site 765874005725 H-loop/switch region; other site 765874005726 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 765874005727 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 765874005728 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 765874005729 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 765874005730 FAD binding pocket [chemical binding]; other site 765874005731 conserved FAD binding motif [chemical binding]; other site 765874005732 phosphate binding motif [ion binding]; other site 765874005733 beta-alpha-beta structure motif; other site 765874005734 NAD binding pocket [chemical binding]; other site 765874005735 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 765874005736 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765874005737 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 765874005738 FtsX-like permease family; Region: FtsX; pfam02687 765874005739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765874005740 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765874005741 Walker A/P-loop; other site 765874005742 ATP binding site [chemical binding]; other site 765874005743 Q-loop/lid; other site 765874005744 ABC transporter signature motif; other site 765874005745 Walker B; other site 765874005746 D-loop; other site 765874005747 H-loop/switch region; other site 765874005748 HlyD family secretion protein; Region: HlyD_3; pfam13437 765874005749 Predicted amidohydrolase [General function prediction only]; Region: COG0388 765874005750 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 765874005751 active site 765874005752 catalytic triad [active] 765874005753 dimer interface [polypeptide binding]; other site 765874005754 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 765874005755 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765874005756 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 765874005757 NAD binding site [chemical binding]; other site 765874005758 substrate binding site [chemical binding]; other site 765874005759 catalytic Zn binding site [ion binding]; other site 765874005760 tetramer interface [polypeptide binding]; other site 765874005761 structural Zn binding site [ion binding]; other site 765874005762 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 765874005763 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765874005764 NAD(P) binding site [chemical binding]; other site 765874005765 catalytic residues [active] 765874005766 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 765874005767 active site 765874005768 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 765874005769 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 765874005770 DNA binding residues [nucleotide binding] 765874005771 chaperone protein DnaJ; Provisional; Region: PRK14279 765874005772 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765874005773 HSP70 interaction site [polypeptide binding]; other site 765874005774 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 765874005775 Zn binding sites [ion binding]; other site 765874005776 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 765874005777 dimer interface [polypeptide binding]; other site 765874005778 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 765874005779 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 765874005780 dimer interface [polypeptide binding]; other site 765874005781 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 765874005782 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 765874005783 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 765874005784 nucleotide binding site [chemical binding]; other site 765874005785 NEF interaction site [polypeptide binding]; other site 765874005786 SBD interface [polypeptide binding]; other site 765874005787 potential frameshift: common BLAST hit: gi|38234574|ref|NP_940341.1| surface-anchored membrane protein 765874005788 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 765874005789 metal ion-dependent adhesion site (MIDAS); other site 765874005790 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 765874005791 active site 765874005792 catalytic site [active] 765874005793 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 765874005794 Domain of unknown function DUF20; Region: UPF0118; pfam01594 765874005795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874005796 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 765874005797 Walker A/P-loop; other site 765874005798 ATP binding site [chemical binding]; other site 765874005799 Q-loop/lid; other site 765874005800 ABC transporter signature motif; other site 765874005801 Walker B; other site 765874005802 D-loop; other site 765874005803 H-loop/switch region; other site 765874005804 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 765874005805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874005806 Q-loop/lid; other site 765874005807 ABC transporter signature motif; other site 765874005808 Walker B; other site 765874005809 D-loop; other site 765874005810 H-loop/switch region; other site 765874005811 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874005812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 765874005813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874005814 putative PBP binding loops; other site 765874005815 dimer interface [polypeptide binding]; other site 765874005816 ABC-ATPase subunit interface; other site 765874005817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874005818 Walker A/P-loop; other site 765874005819 ATP binding site [chemical binding]; other site 765874005820 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874005821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874005822 dimer interface [polypeptide binding]; other site 765874005823 conserved gate region; other site 765874005824 putative PBP binding loops; other site 765874005825 ABC-ATPase subunit interface; other site 765874005826 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 765874005827 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 765874005828 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 765874005829 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 765874005830 adrenodoxin reductase; Provisional; Region: PTZ00188 765874005831 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 765874005832 4Fe-4S binding domain; Region: Fer4; cl02805 765874005833 4Fe-4S binding domain; Region: Fer4; pfam00037 765874005834 Cysteine-rich domain; Region: CCG; pfam02754 765874005835 Cysteine-rich domain; Region: CCG; pfam02754 765874005836 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 765874005837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 765874005838 dimerization interface [polypeptide binding]; other site 765874005839 putative DNA binding site [nucleotide binding]; other site 765874005840 putative Zn2+ binding site [ion binding]; other site 765874005841 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874005842 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874005843 Walker A/P-loop; other site 765874005844 ATP binding site [chemical binding]; other site 765874005845 Q-loop/lid; other site 765874005846 ABC transporter signature motif; other site 765874005847 Walker B; other site 765874005848 D-loop; other site 765874005849 H-loop/switch region; other site 765874005850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765874005851 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874005852 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874005853 putative PBP binding regions; other site 765874005854 ABC-ATPase subunit interface; other site 765874005855 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 765874005856 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765874005857 intersubunit interface [polypeptide binding]; other site 765874005858 UreD urease accessory protein; Region: UreD; cl00530 765874005859 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 765874005860 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 765874005861 UreF; Region: UreF; pfam01730 765874005862 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 765874005863 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 765874005864 dimer interface [polypeptide binding]; other site 765874005865 catalytic residues [active] 765874005866 urease subunit alpha; Reviewed; Region: ureC; PRK13207 765874005867 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 765874005868 subunit interactions [polypeptide binding]; other site 765874005869 active site 765874005870 flap region; other site 765874005871 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 765874005872 gamma-beta subunit interface [polypeptide binding]; other site 765874005873 alpha-beta subunit interface [polypeptide binding]; other site 765874005874 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 765874005875 alpha-gamma subunit interface [polypeptide binding]; other site 765874005876 beta-gamma subunit interface [polypeptide binding]; other site 765874005877 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 765874005878 EamA-like transporter family; Region: EamA; pfam00892 765874005879 EamA-like transporter family; Region: EamA; pfam00892 765874005880 aminotransferase AlaT; Validated; Region: PRK09265 765874005881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765874005882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874005883 homodimer interface [polypeptide binding]; other site 765874005884 catalytic residue [active] 765874005885 YibE/F-like protein; Region: YibE_F; pfam07907 765874005886 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 765874005887 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 765874005888 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 765874005889 dimer interface [polypeptide binding]; other site 765874005890 putative anticodon binding site; other site 765874005891 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765874005892 motif 1; other site 765874005893 dimer interface [polypeptide binding]; other site 765874005894 active site 765874005895 motif 2; other site 765874005896 motif 3; other site 765874005897 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 765874005898 Protein of unknown function (DUF998); Region: DUF998; pfam06197 765874005899 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 765874005900 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 765874005901 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 765874005902 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765874005903 trimer interface [polypeptide binding]; other site 765874005904 active site 765874005905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765874005906 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 765874005907 NAD(P) binding site [chemical binding]; other site 765874005908 catalytic residues [active] 765874005909 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 765874005910 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 765874005911 VanW like protein; Region: VanW; pfam04294 765874005912 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 765874005913 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 765874005914 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 765874005915 Acyltransferase family; Region: Acyl_transf_3; pfam01757 765874005916 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 765874005917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765874005918 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 765874005919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874005920 S-adenosylmethionine binding site [chemical binding]; other site 765874005921 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 765874005922 active site 765874005923 substrate-binding site [chemical binding]; other site 765874005924 metal-binding site [ion binding] 765874005925 GTP binding site [chemical binding]; other site 765874005926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765874005927 S-adenosylmethionine binding site [chemical binding]; other site 765874005928 LabA_like proteins; Region: LabA_like; cd06167 765874005929 putative metal binding site [ion binding]; other site 765874005930 MMPL family; Region: MMPL; pfam03176 765874005931 MMPL family; Region: MMPL; pfam03176 765874005932 Predicted integral membrane protein [Function unknown]; Region: COG0392 765874005933 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 765874005934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 765874005935 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 765874005936 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 765874005937 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 765874005938 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 765874005939 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 765874005940 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 765874005941 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 765874005942 active site 765874005943 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 765874005944 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 765874005945 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 765874005946 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 765874005947 acyl-activating enzyme (AAE) consensus motif; other site 765874005948 active site 765874005949 Cutinase; Region: Cutinase; pfam01083 765874005950 Putative esterase; Region: Esterase; pfam00756 765874005951 S-formylglutathione hydrolase; Region: PLN02442 765874005952 LGFP repeat; Region: LGFP; pfam08310 765874005953 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 765874005954 LGFP repeat; Region: LGFP; pfam08310 765874005955 LGFP repeat; Region: LGFP; pfam08310 765874005956 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 765874005957 Predicted esterase [General function prediction only]; Region: COG0627 765874005958 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 765874005959 UbiA prenyltransferase family; Region: UbiA; pfam01040 765874005960 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 765874005961 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 765874005962 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 765874005963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765874005964 Repair protein; Region: Repair_PSII; pfam04536 765874005965 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 765874005966 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 765874005967 active site 765874005968 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 765874005969 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 765874005970 active site 765874005971 catalytic site [active] 765874005972 metal binding site [ion binding]; metal-binding site 765874005973 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 765874005974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874005975 putative substrate translocation pore; other site 765874005976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874005977 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 765874005978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765874005979 UDP-galactopyranose mutase; Region: GLF; pfam03275 765874005980 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765874005981 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 765874005982 Walker A/P-loop; other site 765874005983 ATP binding site [chemical binding]; other site 765874005984 Q-loop/lid; other site 765874005985 ABC transporter signature motif; other site 765874005986 Walker B; other site 765874005987 D-loop; other site 765874005988 H-loop/switch region; other site 765874005989 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765874005990 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765874005991 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765874005992 putative PBP binding regions; other site 765874005993 ABC-ATPase subunit interface; other site 765874005994 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 765874005995 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 765874005996 putative binding site residues; other site 765874005997 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 765874005998 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 765874005999 amidase catalytic site [active] 765874006000 Zn binding residues [ion binding]; other site 765874006001 substrate binding site [chemical binding]; other site 765874006002 LGFP repeat; Region: LGFP; pfam08310 765874006003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874006004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 765874006005 active site 765874006006 motif I; other site 765874006007 motif II; other site 765874006008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765874006009 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 765874006010 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765874006011 putative acyl-acceptor binding pocket; other site 765874006012 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 765874006013 seryl-tRNA synthetase; Provisional; Region: PRK05431 765874006014 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 765874006015 dimer interface [polypeptide binding]; other site 765874006016 active site 765874006017 motif 1; other site 765874006018 motif 2; other site 765874006019 motif 3; other site 765874006020 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 765874006021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 765874006022 DNA-binding site [nucleotide binding]; DNA binding site 765874006023 UTRA domain; Region: UTRA; pfam07702 765874006024 Septum formation; Region: Septum_form; pfam13845 765874006025 Septum formation; Region: Septum_form; pfam13845 765874006026 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 765874006027 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765874006028 catalytic core [active] 765874006029 Prephenate dehydratase; Region: PDT; pfam00800 765874006030 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 765874006031 putative L-Phe binding site [chemical binding]; other site 765874006032 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 765874006033 Amidase; Region: Amidase; cl11426 765874006034 CAAX protease self-immunity; Region: Abi; pfam02517 765874006035 Transcriptional regulator [Transcription]; Region: LytR; COG1316 765874006036 Htaa; Region: HtaA; pfam04213 765874006037 potential frameshift: common BLAST hit: gi|38234787|ref|NP_940554.1| sodium/alanine symporter 765874006038 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765874006039 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765874006040 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765874006041 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765874006042 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 765874006043 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 765874006044 putative active site [active] 765874006045 catalytic site [active] 765874006046 putative metal binding site [ion binding]; other site 765874006047 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 765874006048 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 765874006049 Nucleoside recognition; Region: Gate; pfam07670 765874006050 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 765874006051 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 765874006052 active site 765874006053 catalytic motif [active] 765874006054 Zn binding site [ion binding]; other site 765874006055 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 765874006056 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 765874006057 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 765874006058 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 765874006059 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 765874006060 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 765874006061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765874006062 NAD binding site [chemical binding]; other site 765874006063 dimer interface [polypeptide binding]; other site 765874006064 substrate binding site [chemical binding]; other site 765874006065 methionine sulfoxide reductase A; Provisional; Region: PRK00058 765874006066 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 765874006067 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 765874006068 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 765874006069 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 765874006070 Predicted flavoprotein [General function prediction only]; Region: COG0431 765874006071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874006072 putative substrate translocation pore; other site 765874006073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765874006074 Abi-like protein; Region: Abi_2; pfam07751 765874006075 potential frameshift: common BLAST hit: gi|38234806|ref|NP_940573.1| sugar phosphate antiporter 765874006076 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 765874006077 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 765874006078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874006079 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 765874006080 homodimer interface [polypeptide binding]; other site 765874006081 chemical substrate binding site [chemical binding]; other site 765874006082 oligomer interface [polypeptide binding]; other site 765874006083 metal binding site [ion binding]; metal-binding site 765874006084 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 765874006085 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 765874006086 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 765874006087 Lsr2; Region: Lsr2; pfam11774 765874006088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765874006089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874006090 active site 765874006091 phosphorylation site [posttranslational modification] 765874006092 intermolecular recognition site; other site 765874006093 dimerization interface [polypeptide binding]; other site 765874006094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765874006095 DNA binding residues [nucleotide binding] 765874006096 dimerization interface [polypeptide binding]; other site 765874006097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 765874006098 Histidine kinase; Region: HisKA_3; pfam07730 765874006099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765874006100 ATP binding site [chemical binding]; other site 765874006101 Mg2+ binding site [ion binding]; other site 765874006102 G-X-G motif; other site 765874006103 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 765874006104 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 765874006105 active site 765874006106 catalytic site [active] 765874006107 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 765874006108 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 765874006109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 765874006110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 765874006111 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 765874006112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765874006113 Ligand Binding Site [chemical binding]; other site 765874006114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765874006115 Ligand Binding Site [chemical binding]; other site 765874006116 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 765874006117 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765874006118 active site 765874006119 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 765874006120 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765874006121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765874006122 Walker A/P-loop; other site 765874006123 ATP binding site [chemical binding]; other site 765874006124 Q-loop/lid; other site 765874006125 ABC transporter signature motif; other site 765874006126 Walker B; other site 765874006127 D-loop; other site 765874006128 H-loop/switch region; other site 765874006129 Predicted transcriptional regulators [Transcription]; Region: COG1725 765874006130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 765874006131 DNA-binding site [nucleotide binding]; DNA binding site 765874006132 LabA_like proteins; Region: LabA_like; cd06167 765874006133 putative metal binding site [ion binding]; other site 765874006134 Uncharacterized conserved protein [Function unknown]; Region: COG1432 765874006135 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 765874006136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765874006137 catalytic residues [active] 765874006138 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 765874006139 metal-binding site [ion binding] 765874006140 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765874006141 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 765874006142 metal-binding site [ion binding] 765874006143 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765874006144 benzoate transport; Region: 2A0115; TIGR00895 765874006145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874006146 putative substrate translocation pore; other site 765874006147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765874006148 replicative DNA helicase; Provisional; Region: PRK05636 765874006149 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 765874006150 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 765874006151 Walker A motif; other site 765874006152 ATP binding site [chemical binding]; other site 765874006153 Walker B motif; other site 765874006154 DNA binding loops [nucleotide binding] 765874006155 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 765874006156 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 765874006157 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 765874006158 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 765874006159 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 765874006160 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 765874006161 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765874006162 dimer interface [polypeptide binding]; other site 765874006163 ssDNA binding site [nucleotide binding]; other site 765874006164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765874006165 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 765874006166 Predicted integral membrane protein [Function unknown]; Region: COG5650 765874006167 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 765874006168 Transglycosylase; Region: Transgly; pfam00912 765874006169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 765874006170 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 765874006171 MarR family; Region: MarR; pfam01047 765874006172 MarR family; Region: MarR_2; cl17246 765874006173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765874006174 Ligand Binding Site [chemical binding]; other site 765874006175 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765874006176 Ligand Binding Site [chemical binding]; other site 765874006177 short chain dehydrogenase; Provisional; Region: PRK08219 765874006178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765874006179 NAD(P) binding site [chemical binding]; other site 765874006180 active site 765874006181 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 765874006182 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 765874006183 active site residue [active] 765874006184 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 765874006185 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 765874006186 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 765874006187 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 765874006188 dimerization interface [polypeptide binding]; other site 765874006189 DPS ferroxidase diiron center [ion binding]; other site 765874006190 ion pore; other site 765874006191 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 765874006192 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 765874006193 putative DNA binding site [nucleotide binding]; other site 765874006194 catalytic residue [active] 765874006195 putative H2TH interface [polypeptide binding]; other site 765874006196 putative catalytic residues [active] 765874006197 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 765874006198 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 765874006199 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 765874006200 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 765874006201 putative substrate binding site [chemical binding]; other site 765874006202 putative ATP binding site [chemical binding]; other site 765874006203 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 765874006204 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 765874006205 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 765874006206 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 765874006207 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 765874006208 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 765874006209 HIGH motif; other site 765874006210 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 765874006211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874006212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765874006213 active site 765874006214 KMSKS motif; other site 765874006215 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 765874006216 tRNA binding surface [nucleotide binding]; other site 765874006217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765874006218 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765874006219 Walker A/P-loop; other site 765874006220 ATP binding site [chemical binding]; other site 765874006221 Q-loop/lid; other site 765874006222 ABC transporter signature motif; other site 765874006223 Walker B; other site 765874006224 D-loop; other site 765874006225 H-loop/switch region; other site 765874006226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765874006227 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 765874006228 FtsX-like permease family; Region: FtsX; pfam02687 765874006229 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874006230 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874006231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 765874006232 Histidine kinase; Region: HisKA_3; pfam07730 765874006233 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 765874006234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765874006235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765874006236 active site 765874006237 phosphorylation site [posttranslational modification] 765874006238 intermolecular recognition site; other site 765874006239 dimerization interface [polypeptide binding]; other site 765874006240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765874006241 DNA binding residues [nucleotide binding] 765874006242 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874006243 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 765874006244 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874006245 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 765874006246 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 765874006247 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 765874006248 active site 765874006249 trimer interface [polypeptide binding]; other site 765874006250 allosteric site; other site 765874006251 active site lid [active] 765874006252 hexamer (dimer of trimers) interface [polypeptide binding]; other site 765874006253 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 765874006254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 765874006255 active site 765874006256 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 765874006257 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 765874006258 putative active site cavity [active] 765874006259 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 765874006260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 765874006261 nucleotide binding site [chemical binding]; other site 765874006262 Transcriptional regulators [Transcription]; Region: FadR; COG2186 765874006263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 765874006264 DNA-binding site [nucleotide binding]; DNA binding site 765874006265 FCD domain; Region: FCD; pfam07729 765874006266 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 765874006267 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 765874006268 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765874006269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874006270 dimer interface [polypeptide binding]; other site 765874006271 conserved gate region; other site 765874006272 putative PBP binding loops; other site 765874006273 ABC-ATPase subunit interface; other site 765874006274 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 765874006275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765874006276 dimer interface [polypeptide binding]; other site 765874006277 conserved gate region; other site 765874006278 putative PBP binding loops; other site 765874006279 ABC-ATPase subunit interface; other site 765874006280 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 765874006281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874006282 Walker A/P-loop; other site 765874006283 ATP binding site [chemical binding]; other site 765874006284 Q-loop/lid; other site 765874006285 ABC transporter signature motif; other site 765874006286 Walker B; other site 765874006287 D-loop; other site 765874006288 H-loop/switch region; other site 765874006289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 765874006290 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 765874006291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765874006292 Walker A/P-loop; other site 765874006293 ATP binding site [chemical binding]; other site 765874006294 Q-loop/lid; other site 765874006295 ABC transporter signature motif; other site 765874006296 Walker B; other site 765874006297 D-loop; other site 765874006298 H-loop/switch region; other site 765874006299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765874006300 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 765874006301 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 765874006302 inhibitor site; inhibition site 765874006303 active site 765874006304 dimer interface [polypeptide binding]; other site 765874006305 catalytic residue [active] 765874006306 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 765874006307 active site 765874006308 catalytic residues [active] 765874006309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 765874006310 hypothetical protein; Provisional; Region: PRK13663 765874006311 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 765874006312 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 765874006313 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 765874006314 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765874006315 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 765874006316 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 765874006317 substrate binding pocket [chemical binding]; other site 765874006318 substrate-Mg2+ binding site; other site 765874006319 aspartate-rich region 1; other site 765874006320 aspartate-rich region 2; other site 765874006321 phytoene desaturase; Region: crtI_fam; TIGR02734 765874006322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765874006323 SdpI/YhfL protein family; Region: SdpI; pfam13630 765874006324 anthranilate synthase component I; Provisional; Region: PRK13564 765874006325 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 765874006326 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 765874006327 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 765874006328 Glutamine amidotransferase class-I; Region: GATase; pfam00117 765874006329 glutamine binding [chemical binding]; other site 765874006330 catalytic triad [active] 765874006331 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 765874006332 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 765874006333 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 765874006334 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 765874006335 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 765874006336 active site 765874006337 ribulose/triose binding site [chemical binding]; other site 765874006338 phosphate binding site [ion binding]; other site 765874006339 substrate (anthranilate) binding pocket [chemical binding]; other site 765874006340 product (indole) binding pocket [chemical binding]; other site 765874006341 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 765874006342 active site 765874006343 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 765874006344 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 765874006345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765874006346 catalytic residue [active] 765874006347 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 765874006348 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 765874006349 substrate binding site [chemical binding]; other site 765874006350 active site 765874006351 catalytic residues [active] 765874006352 heterodimer interface [polypeptide binding]; other site 765874006353 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 765874006354 iron-sulfur cluster [ion binding]; other site 765874006355 [2Fe-2S] cluster binding site [ion binding]; other site 765874006356 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 765874006357 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 765874006358 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 765874006359 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 765874006360 hypothetical protein; Validated; Region: PRK00228 765874006361 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 765874006362 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 765874006363 active site 765874006364 NTP binding site [chemical binding]; other site 765874006365 metal binding triad [ion binding]; metal-binding site 765874006366 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 765874006367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765874006368 Zn2+ binding site [ion binding]; other site 765874006369 Mg2+ binding site [ion binding]; other site 765874006370 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 765874006371 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 765874006372 active site 765874006373 Ap6A binding site [chemical binding]; other site 765874006374 nudix motif; other site 765874006375 metal binding site [ion binding]; metal-binding site 765874006376 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 765874006377 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 765874006378 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 765874006379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765874006380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765874006381 DNA binding residues [nucleotide binding] 765874006382 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 765874006383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765874006384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765874006385 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765874006386 catalytic residues [active] 765874006387 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 765874006388 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 765874006389 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 765874006390 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 765874006391 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 765874006392 active site 765874006393 metal binding site [ion binding]; metal-binding site 765874006394 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 765874006395 ParB-like nuclease domain; Region: ParBc; pfam02195 765874006396 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 765874006397 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 765874006398 P-loop; other site 765874006399 Magnesium ion binding site [ion binding]; other site 765874006400 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 765874006401 Magnesium ion binding site [ion binding]; other site 765874006402 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 765874006403 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 765874006404 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 765874006405 Haemolytic domain; Region: Haemolytic; pfam01809 765874006406 ribonuclease P; Reviewed; Region: rnpA; PRK03459