-- dump date   	20140619_052640
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
889513000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
889513000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513000003	Walker A motif; other site
889513000004	ATP binding site [chemical binding]; other site
889513000005	Walker B motif; other site
889513000006	arginine finger; other site
889513000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
889513000008	DnaA box-binding interface [nucleotide binding]; other site
889513000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
889513000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
889513000011	putative DNA binding surface [nucleotide binding]; other site
889513000012	dimer interface [polypeptide binding]; other site
889513000013	beta-clamp/clamp loader binding surface; other site
889513000014	beta-clamp/translesion DNA polymerase binding surface; other site
889513000015	recombination protein F; Reviewed; Region: recF; PRK00064
889513000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
889513000017	Walker A/P-loop; other site
889513000018	ATP binding site [chemical binding]; other site
889513000019	Q-loop/lid; other site
889513000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513000021	ABC transporter signature motif; other site
889513000022	Walker B; other site
889513000023	D-loop; other site
889513000024	H-loop/switch region; other site
889513000025	hypothetical protein; Provisional; Region: PRK00111
889513000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
889513000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513000028	ATP binding site [chemical binding]; other site
889513000029	Mg2+ binding site [ion binding]; other site
889513000030	G-X-G motif; other site
889513000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
889513000032	anchoring element; other site
889513000033	dimer interface [polypeptide binding]; other site
889513000034	ATP binding site [chemical binding]; other site
889513000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
889513000036	active site
889513000037	putative metal-binding site [ion binding]; other site
889513000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
889513000039	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
889513000040	metal binding site [ion binding]; metal-binding site
889513000041	DNA gyrase subunit A; Validated; Region: PRK05560
889513000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
889513000043	CAP-like domain; other site
889513000044	active site
889513000045	primary dimer interface [polypeptide binding]; other site
889513000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889513000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889513000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889513000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889513000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889513000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889513000052	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
889513000053	YwiC-like protein; Region: YwiC; pfam14256
889513000054	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
889513000055	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
889513000056	putative ligand binding site [chemical binding]; other site
889513000057	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
889513000058	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
889513000059	TM-ABC transporter signature motif; other site
889513000060	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
889513000061	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
889513000062	Walker A/P-loop; other site
889513000063	ATP binding site [chemical binding]; other site
889513000064	Q-loop/lid; other site
889513000065	ABC transporter signature motif; other site
889513000066	Walker B; other site
889513000067	D-loop; other site
889513000068	H-loop/switch region; other site
889513000069	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
889513000070	active site
889513000071	Rhomboid family; Region: Rhomboid; pfam01694
889513000072	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
889513000073	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
889513000074	Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576
889513000075	putative active site [active]
889513000076	catalytic site [active]
889513000077	Mg binding site [ion binding]; other site
889513000078	catalytic loop [active]
889513000079	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513000080	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513000081	Walker A/P-loop; other site
889513000082	ATP binding site [chemical binding]; other site
889513000083	Q-loop/lid; other site
889513000084	ABC transporter signature motif; other site
889513000085	Walker B; other site
889513000086	D-loop; other site
889513000087	H-loop/switch region; other site
889513000088	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
889513000089	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513000090	ABC-ATPase subunit  interface; other site
889513000091	dimer interface [polypeptide binding]; other site
889513000092	putative PBP binding regions; other site
889513000093	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513000094	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513000095	ABC-ATPase subunit  interface; other site
889513000096	dimer interface [polypeptide binding]; other site
889513000097	putative PBP binding regions; other site
889513000098	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
889513000099	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
889513000100	siderophore binding site; other site
889513000101	putative septation inhibitor protein; Reviewed; Region: PRK00159
889513000102	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
889513000103	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
889513000104	active site
889513000105	ATP binding site [chemical binding]; other site
889513000106	substrate binding site [chemical binding]; other site
889513000107	activation loop (A-loop); other site
889513000108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
889513000109	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513000110	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513000111	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513000112	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513000113	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
889513000114	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
889513000115	active site
889513000116	ATP binding site [chemical binding]; other site
889513000117	substrate binding site [chemical binding]; other site
889513000118	activation loop (A-loop); other site
889513000119	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
889513000120	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
889513000121	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
889513000122	Protein phosphatase 2C; Region: PP2C; pfam00481
889513000123	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
889513000124	active site
889513000125	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
889513000126	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
889513000127	phosphopeptide binding site; other site
889513000128	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
889513000129	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
889513000130	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
889513000131	phosphopeptide binding site; other site
889513000132	CAAX protease self-immunity; Region: Abi; pfam02517
889513000133	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
889513000134	Predicted transcriptional regulators [Transcription]; Region: COG1695
889513000135	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
889513000136	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
889513000137	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513000138	intersubunit interface [polypeptide binding]; other site
889513000139	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513000140	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513000141	Walker A/P-loop; other site
889513000142	ATP binding site [chemical binding]; other site
889513000143	Q-loop/lid; other site
889513000144	ABC transporter signature motif; other site
889513000145	Walker B; other site
889513000146	D-loop; other site
889513000147	H-loop/switch region; other site
889513000148	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513000149	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513000150	ABC-ATPase subunit  interface; other site
889513000151	dimer interface [polypeptide binding]; other site
889513000152	putative PBP binding regions; other site
889513000153	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
889513000154	MgtE intracellular N domain; Region: MgtE_N; smart00924
889513000155	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
889513000156	Divalent cation transporter; Region: MgtE; pfam01769
889513000157	trehalose synthase; Region: treS_nterm; TIGR02456
889513000158	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348
889513000159	active site
889513000160	catalytic site [active]
889513000161	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
889513000162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513000163	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513000164	putative substrate translocation pore; other site
889513000165	Anti-sigma-K factor rskA; Region: RskA; pfam10099
889513000166	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
889513000167	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513000168	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513000169	DNA binding residues [nucleotide binding]
889513000170	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
889513000171	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
889513000172	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
889513000173	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
889513000174	catalytic residues [active]
889513000175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
889513000176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513000177	dimer interface [polypeptide binding]; other site
889513000178	conserved gate region; other site
889513000179	putative PBP binding loops; other site
889513000180	ABC-ATPase subunit interface; other site
889513000181	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
889513000182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513000183	Walker A/P-loop; other site
889513000184	ATP binding site [chemical binding]; other site
889513000185	Q-loop/lid; other site
889513000186	ABC transporter signature motif; other site
889513000187	Walker B; other site
889513000188	D-loop; other site
889513000189	H-loop/switch region; other site
889513000190	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
889513000191	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
889513000192	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
889513000193	putative metal binding site [ion binding]; other site
889513000194	biotin synthase; Validated; Region: PRK06256
889513000195	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513000196	FeS/SAM binding site; other site
889513000197	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
889513000198	MepB protein; Region: MepB; cl01985
889513000199	AMP nucleosidase; Provisional; Region: PRK08292
889513000200	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
889513000201	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
889513000202	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
889513000203	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
889513000204	active site
889513000205	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
889513000206	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
889513000207	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
889513000208	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
889513000209	Lipase (class 2); Region: Lipase_2; pfam01674
889513000210	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
889513000211	dimer interface [polypeptide binding]; other site
889513000212	FMN binding site [chemical binding]; other site
889513000213	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
889513000214	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
889513000215	trimer interface [polypeptide binding]; other site
889513000216	putative metal binding site [ion binding]; other site
889513000217	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
889513000218	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
889513000219	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
889513000220	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
889513000221	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
889513000222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513000223	Coenzyme A binding pocket [chemical binding]; other site
889513000224	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
889513000225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
889513000226	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889513000227	MarR family; Region: MarR; pfam01047
889513000228	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
889513000229	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
889513000230	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
889513000231	hypothetical protein; Provisional; Region: PRK10621
889513000232	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889513000233	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
889513000234	active site
889513000235	phosphorylation site [posttranslational modification]
889513000236	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
889513000237	active site
889513000238	P-loop; other site
889513000239	phosphorylation site [posttranslational modification]
889513000240	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
889513000241	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
889513000242	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513000243	ATP binding site [chemical binding]; other site
889513000244	putative Mg++ binding site [ion binding]; other site
889513000245	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513000246	nucleotide binding region [chemical binding]; other site
889513000247	ATP-binding site [chemical binding]; other site
889513000248	Helicase associated domain (HA2); Region: HA2; pfam04408
889513000249	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
889513000250	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
889513000251	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
889513000252	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
889513000253	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513000254	NAD(P) binding site [chemical binding]; other site
889513000255	active site
889513000256	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
889513000257	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889513000258	RNA binding surface [nucleotide binding]; other site
889513000259	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
889513000260	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889513000261	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
889513000262	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
889513000263	DNA binding site [nucleotide binding]
889513000264	active site
889513000265	Domain of unknown function (DUF222); Region: DUF222; pfam02720
889513000266	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
889513000267	active site
889513000268	glycerol kinase; Provisional; Region: glpK; PRK00047
889513000269	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
889513000270	nucleotide binding site [chemical binding]; other site
889513000271	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
889513000272	amphipathic channel; other site
889513000273	Asn-Pro-Ala signature motifs; other site
889513000274	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
889513000275	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
889513000276	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
889513000277	active site
889513000278	Zn binding site [ion binding]; other site
889513000279	Protease prsW family; Region: PrsW-protease; pfam13367
889513000280	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
889513000281	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
889513000282	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
889513000283	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
889513000284	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
889513000285	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
889513000286	classical (c) SDRs; Region: SDR_c; cd05233
889513000287	NAD(P) binding site [chemical binding]; other site
889513000288	active site
889513000289	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
889513000290	FAD binding domain; Region: FAD_binding_4; pfam01565
889513000291	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
889513000292	Predicted membrane protein [Function unknown]; Region: COG2246
889513000293	GtrA-like protein; Region: GtrA; pfam04138
889513000294	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
889513000295	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
889513000296	active site
889513000297	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
889513000298	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
889513000299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
889513000300	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
889513000301	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
889513000302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513000303	ABC-ATPase subunit  interface; other site
889513000304	dimer interface [polypeptide binding]; other site
889513000305	putative PBP binding regions; other site
889513000306	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513000307	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
889513000308	intersubunit interface [polypeptide binding]; other site
889513000309	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
889513000310	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889513000311	active site
889513000312	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
889513000313	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
889513000314	Walker A/P-loop; other site
889513000315	ATP binding site [chemical binding]; other site
889513000316	Q-loop/lid; other site
889513000317	ABC transporter signature motif; other site
889513000318	Walker B; other site
889513000319	D-loop; other site
889513000320	H-loop/switch region; other site
889513000321	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
889513000322	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
889513000323	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
889513000324	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
889513000325	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
889513000326	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
889513000327	NAD(P) binding site [chemical binding]; other site
889513000328	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
889513000329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513000330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513000331	homodimer interface [polypeptide binding]; other site
889513000332	catalytic residue [active]
889513000333	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
889513000334	transmembrane helices; other site
889513000335	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
889513000336	CAT RNA binding domain; Region: CAT_RBD; smart01061
889513000337	PRD domain; Region: PRD; pfam00874
889513000338	PRD domain; Region: PRD; pfam00874
889513000339	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
889513000340	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889513000341	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
889513000342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889513000343	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
889513000344	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889513000345	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889513000346	DNA-binding site [nucleotide binding]; DNA binding site
889513000347	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513000348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513000349	homodimer interface [polypeptide binding]; other site
889513000350	catalytic residue [active]
889513000351	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
889513000352	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
889513000353	active site
889513000354	multimer interface [polypeptide binding]; other site
889513000355	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
889513000356	predicted active site [active]
889513000357	catalytic triad [active]
889513000358	prephenate dehydrogenase; Validated; Region: PRK06545
889513000359	prephenate dehydrogenase; Validated; Region: PRK08507
889513000360	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
889513000361	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
889513000362	nucleoside/Zn binding site; other site
889513000363	dimer interface [polypeptide binding]; other site
889513000364	catalytic motif [active]
889513000365	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
889513000366	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
889513000367	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
889513000368	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
889513000369	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
889513000370	active site
889513000371	KMSKS motif; other site
889513000372	fructuronate transporter; Provisional; Region: PRK10034; cl15264
889513000373	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
889513000374	Shikimate kinase; Region: SKI; pfam01202
889513000375	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
889513000376	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
889513000377	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
889513000378	putative NAD(P) binding site [chemical binding]; other site
889513000379	catalytic Zn binding site [ion binding]; other site
889513000380	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
889513000381	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
889513000382	NADP binding site [chemical binding]; other site
889513000383	homodimer interface [polypeptide binding]; other site
889513000384	active site
889513000385	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
889513000386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513000387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513000388	homodimer interface [polypeptide binding]; other site
889513000389	catalytic residue [active]
889513000390	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
889513000391	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
889513000392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513000393	Walker A motif; other site
889513000394	ATP binding site [chemical binding]; other site
889513000395	Walker B motif; other site
889513000396	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
889513000397	arginine finger; other site
889513000398	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
889513000399	hypothetical protein; Validated; Region: PRK00153
889513000400	recombination protein RecR; Reviewed; Region: recR; PRK00076
889513000401	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
889513000402	RecR protein; Region: RecR; pfam02132
889513000403	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
889513000404	putative active site [active]
889513000405	putative metal-binding site [ion binding]; other site
889513000406	tetramer interface [polypeptide binding]; other site
889513000407	putative transporter; Provisional; Region: PRK09821
889513000408	GntP family permease; Region: GntP_permease; pfam02447
889513000409	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
889513000410	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
889513000411	Transcriptional regulators [Transcription]; Region: FadR; COG2186
889513000412	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889513000413	DNA-binding site [nucleotide binding]; DNA binding site
889513000414	FCD domain; Region: FCD; pfam07729
889513000415	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
889513000416	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
889513000417	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
889513000418	catalytic triad [active]
889513000419	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
889513000420	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513000421	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
889513000422	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
889513000423	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
889513000424	active site
889513000425	catalytic site [active]
889513000426	substrate binding site [chemical binding]; other site
889513000427	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
889513000428	2-isopropylmalate synthase; Validated; Region: PRK03739
889513000429	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
889513000430	active site
889513000431	catalytic residues [active]
889513000432	metal binding site [ion binding]; metal-binding site
889513000433	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
889513000434	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
889513000435	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513000436	DNA binding residues [nucleotide binding]
889513000437	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
889513000438	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
889513000439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513000440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513000441	putative substrate translocation pore; other site
889513000442	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
889513000443	intersubunit interface [polypeptide binding]; other site
889513000444	active site
889513000445	catalytic residue [active]
889513000446	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
889513000447	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
889513000448	active site
889513000449	substrate binding site [chemical binding]; other site
889513000450	metal binding site [ion binding]; metal-binding site
889513000451	TQXA domain; Region: TQXA_dom; TIGR03934
889513000452	Cna protein B-type domain; Region: Cna_B; pfam05738
889513000453	Cna protein B-type domain; Region: Cna_B; pfam05738
889513000454	Cna protein B-type domain; Region: Cna_B; pfam05738
889513000455	aspartate kinase; Reviewed; Region: PRK06635
889513000456	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
889513000457	putative nucleotide binding site [chemical binding]; other site
889513000458	putative catalytic residues [active]
889513000459	putative Mg ion binding site [ion binding]; other site
889513000460	putative aspartate binding site [chemical binding]; other site
889513000461	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
889513000462	putative allosteric regulatory site; other site
889513000463	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
889513000464	putative allosteric regulatory residue; other site
889513000465	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
889513000466	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
889513000467	RNA polymerase sigma factor; Provisional; Region: PRK12535
889513000468	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513000469	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
889513000470	DNA binding residues [nucleotide binding]
889513000471	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
889513000472	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
889513000473	heme binding pocket [chemical binding]; other site
889513000474	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
889513000475	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
889513000476	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
889513000477	Walker A/P-loop; other site
889513000478	ATP binding site [chemical binding]; other site
889513000479	Q-loop/lid; other site
889513000480	ABC transporter signature motif; other site
889513000481	Walker B; other site
889513000482	D-loop; other site
889513000483	H-loop/switch region; other site
889513000484	TOBE domain; Region: TOBE_2; pfam08402
889513000485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513000486	dimer interface [polypeptide binding]; other site
889513000487	conserved gate region; other site
889513000488	ABC-ATPase subunit interface; other site
889513000489	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
889513000490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513000491	putative substrate translocation pore; other site
889513000492	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889513000493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513000494	active site
889513000495	phosphorylation site [posttranslational modification]
889513000496	intermolecular recognition site; other site
889513000497	dimerization interface [polypeptide binding]; other site
889513000498	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889513000499	DNA binding site [nucleotide binding]
889513000500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889513000501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889513000502	dimer interface [polypeptide binding]; other site
889513000503	phosphorylation site [posttranslational modification]
889513000504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513000505	ATP binding site [chemical binding]; other site
889513000506	Mg2+ binding site [ion binding]; other site
889513000507	G-X-G motif; other site
889513000508	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
889513000509	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
889513000510	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
889513000511	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
889513000512	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889513000513	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
889513000514	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
889513000515	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889513000516	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
889513000517	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
889513000518	Predicted membrane protein [Function unknown]; Region: COG1511
889513000519	Predicted membrane protein [Function unknown]; Region: COG1511
889513000520	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
889513000521	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
889513000522	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
889513000523	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
889513000524	putative active site [active]
889513000525	putative metal binding site [ion binding]; other site
889513000526	Yqey-like protein; Region: YqeY; pfam09424
889513000527	Transglycosylase; Region: Transgly; pfam00912
889513000528	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
889513000529	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
889513000530	PASTA domain; Region: PASTA; pfam03793
889513000531	Transcription factor WhiB; Region: Whib; pfam02467
889513000532	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
889513000533	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
889513000534	homotrimer interaction site [polypeptide binding]; other site
889513000535	putative active site [active]
889513000536	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
889513000537	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
889513000538	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
889513000539	ligand binding site [chemical binding]; other site
889513000540	flexible hinge region; other site
889513000541	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
889513000542	putative switch regulator; other site
889513000543	non-specific DNA interactions [nucleotide binding]; other site
889513000544	DNA binding site [nucleotide binding]
889513000545	sequence specific DNA binding site [nucleotide binding]; other site
889513000546	putative cAMP binding site [chemical binding]; other site
889513000547	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
889513000548	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
889513000549	minor groove reading motif; other site
889513000550	helix-hairpin-helix signature motif; other site
889513000551	substrate binding pocket [chemical binding]; other site
889513000552	active site
889513000553	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
889513000554	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
889513000555	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
889513000556	catalytic residues [active]
889513000557	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
889513000558	putative active site [active]
889513000559	putative CoA binding site [chemical binding]; other site
889513000560	nudix motif; other site
889513000561	metal binding site [ion binding]; metal-binding site
889513000562	Colicin V production protein; Region: Colicin_V; pfam02674
889513000563	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
889513000564	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
889513000565	active site
889513000566	substrate binding sites [chemical binding]; other site
889513000567	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889513000568	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889513000569	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
889513000570	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513000571	motif II; other site
889513000572	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
889513000573	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
889513000574	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
889513000575	ATP binding site [chemical binding]; other site
889513000576	Walker A motif; other site
889513000577	hexamer interface [polypeptide binding]; other site
889513000578	Walker B motif; other site
889513000579	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
889513000580	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
889513000581	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
889513000582	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
889513000583	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513000584	ATP binding site [chemical binding]; other site
889513000585	putative Mg++ binding site [ion binding]; other site
889513000586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513000587	nucleotide binding region [chemical binding]; other site
889513000588	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
889513000589	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
889513000590	DNA-binding site [nucleotide binding]; DNA binding site
889513000591	RNA-binding motif; other site
889513000592	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
889513000593	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
889513000594	active site
889513000595	interdomain interaction site; other site
889513000596	putative metal-binding site [ion binding]; other site
889513000597	nucleotide binding site [chemical binding]; other site
889513000598	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
889513000599	domain I; other site
889513000600	DNA binding groove [nucleotide binding]
889513000601	phosphate binding site [ion binding]; other site
889513000602	domain II; other site
889513000603	domain III; other site
889513000604	nucleotide binding site [chemical binding]; other site
889513000605	catalytic site [active]
889513000606	domain IV; other site
889513000607	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
889513000608	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
889513000609	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
889513000610	Predicted membrane protein [Function unknown]; Region: COG1297
889513000611	putative oligopeptide transporter, OPT family; Region: TIGR00733
889513000612	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889513000613	dimerization interface [polypeptide binding]; other site
889513000614	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
889513000615	cyclase homology domain; Region: CHD; cd07302
889513000616	nucleotidyl binding site; other site
889513000617	metal binding site [ion binding]; metal-binding site
889513000618	dimer interface [polypeptide binding]; other site
889513000619	DNA polymerase III subunit delta'; Validated; Region: PRK07940
889513000620	DNA polymerase III subunit delta'; Validated; Region: PRK08485
889513000621	acyl-CoA synthetase; Validated; Region: PRK07788
889513000622	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513000623	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513000624	acyl-activating enzyme (AAE) consensus motif; other site
889513000625	acyl-activating enzyme (AAE) consensus motif; other site
889513000626	AMP binding site [chemical binding]; other site
889513000627	active site
889513000628	CoA binding site [chemical binding]; other site
889513000629	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
889513000630	active site
889513000631	catalytic triad [active]
889513000632	oxyanion hole [active]
889513000633	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
889513000634	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
889513000635	substrate binding site; other site
889513000636	tetramer interface; other site
889513000637	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
889513000638	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
889513000639	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
889513000640	NADP binding site [chemical binding]; other site
889513000641	active site
889513000642	putative substrate binding site [chemical binding]; other site
889513000643	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
889513000644	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
889513000645	NAD binding site [chemical binding]; other site
889513000646	substrate binding site [chemical binding]; other site
889513000647	homodimer interface [polypeptide binding]; other site
889513000648	active site
889513000649	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
889513000650	Zn binding site [ion binding]; other site
889513000651	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
889513000652	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889513000653	Putative esterase; Region: Esterase; pfam00756
889513000654	Peptidase family S64; Region: Peptidase_S64; pfam08192
889513000655	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
889513000656	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
889513000657	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889513000658	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889513000659	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
889513000660	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889513000661	non-specific DNA binding site [nucleotide binding]; other site
889513000662	salt bridge; other site
889513000663	sequence-specific DNA binding site [nucleotide binding]; other site
889513000664	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
889513000665	Domain of unknown function (DUF955); Region: DUF955; pfam06114
889513000666	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
889513000667	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
889513000668	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
889513000669	putative Iron-sulfur protein interface [polypeptide binding]; other site
889513000670	proximal heme binding site [chemical binding]; other site
889513000671	distal heme binding site [chemical binding]; other site
889513000672	putative dimer interface [polypeptide binding]; other site
889513000673	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
889513000674	L-aspartate oxidase; Provisional; Region: PRK06175
889513000675	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
889513000676	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
889513000677	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
889513000678	Predicted membrane protein [Function unknown]; Region: COG2733
889513000679	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
889513000680	Class I aldolases; Region: Aldolase_Class_I; cl17187
889513000681	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
889513000682	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
889513000683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513000684	FeS/SAM binding site; other site
889513000685	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
889513000686	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
889513000687	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
889513000688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
889513000689	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
889513000690	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
889513000691	FAD binding domain; Region: FAD_binding_4; pfam01565
889513000692	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
889513000693	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
889513000694	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
889513000695	acyl-activating enzyme (AAE) consensus motif; other site
889513000696	putative AMP binding site [chemical binding]; other site
889513000697	putative active site [active]
889513000698	putative CoA binding site [chemical binding]; other site
889513000699	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
889513000700	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
889513000701	putative ADP-binding pocket [chemical binding]; other site
889513000702	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889513000703	catalytic core [active]
889513000704	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889513000705	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
889513000706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889513000707	dimer interface [polypeptide binding]; other site
889513000708	phosphorylation site [posttranslational modification]
889513000709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513000710	ATP binding site [chemical binding]; other site
889513000711	Mg2+ binding site [ion binding]; other site
889513000712	G-X-G motif; other site
889513000713	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889513000714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513000715	active site
889513000716	phosphorylation site [posttranslational modification]
889513000717	intermolecular recognition site; other site
889513000718	dimerization interface [polypeptide binding]; other site
889513000719	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889513000720	DNA binding site [nucleotide binding]
889513000721	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
889513000722	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
889513000723	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
889513000724	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
889513000725	DNA binding domain, excisionase family; Region: excise; TIGR01764
889513000726	Thioredoxin; Region: Thioredoxin_4; cl17273
889513000727	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
889513000728	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
889513000729	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
889513000730	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
889513000731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513000732	motif II; other site
889513000733	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
889513000734	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
889513000735	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
889513000736	tRNA; other site
889513000737	putative tRNA binding site [nucleotide binding]; other site
889513000738	putative NADP binding site [chemical binding]; other site
889513000739	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
889513000740	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
889513000741	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
889513000742	domain interfaces; other site
889513000743	active site
889513000744	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
889513000745	active site
889513000746	homodimer interface [polypeptide binding]; other site
889513000747	SAM binding site [chemical binding]; other site
889513000748	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
889513000749	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
889513000750	active site
889513000751	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
889513000752	dimer interface [polypeptide binding]; other site
889513000753	active site
889513000754	Schiff base residues; other site
889513000755	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
889513000756	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
889513000757	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
889513000758	substrate binding site [chemical binding]; other site
889513000759	active site
889513000760	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
889513000761	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
889513000762	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
889513000763	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
889513000764	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889513000765	inhibitor-cofactor binding pocket; inhibition site
889513000766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513000767	catalytic residue [active]
889513000768	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889513000769	catalytic core [active]
889513000770	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
889513000771	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
889513000772	catalytic residues [active]
889513000773	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
889513000774	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
889513000775	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
889513000776	ResB-like family; Region: ResB; pfam05140
889513000777	Methyltransferase domain; Region: Methyltransf_31; pfam13847
889513000778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513000779	S-adenosylmethionine binding site [chemical binding]; other site
889513000780	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513000781	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513000782	Walker A/P-loop; other site
889513000783	ATP binding site [chemical binding]; other site
889513000784	Q-loop/lid; other site
889513000785	ABC transporter signature motif; other site
889513000786	Walker B; other site
889513000787	D-loop; other site
889513000788	H-loop/switch region; other site
889513000789	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
889513000790	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513000791	intersubunit interface [polypeptide binding]; other site
889513000792	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
889513000793	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513000794	ABC-ATPase subunit  interface; other site
889513000795	dimer interface [polypeptide binding]; other site
889513000796	putative PBP binding regions; other site
889513000797	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
889513000798	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
889513000799	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
889513000800	UbiA prenyltransferase family; Region: UbiA; pfam01040
889513000801	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
889513000802	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513000803	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513000804	acyl-activating enzyme (AAE) consensus motif; other site
889513000805	acyl-activating enzyme (AAE) consensus motif; other site
889513000806	AMP binding site [chemical binding]; other site
889513000807	active site
889513000808	CoA binding site [chemical binding]; other site
889513000809	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
889513000810	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889513000811	substrate binding site [chemical binding]; other site
889513000812	oxyanion hole (OAH) forming residues; other site
889513000813	trimer interface [polypeptide binding]; other site
889513000814	O-succinylbenzoate synthase; Provisional; Region: PRK02901
889513000815	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
889513000816	active site
889513000817	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
889513000818	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
889513000819	dimer interface [polypeptide binding]; other site
889513000820	tetramer interface [polypeptide binding]; other site
889513000821	PYR/PP interface [polypeptide binding]; other site
889513000822	TPP binding site [chemical binding]; other site
889513000823	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
889513000824	TPP-binding site; other site
889513000825	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
889513000826	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
889513000827	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889513000828	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
889513000829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513000830	S-adenosylmethionine binding site [chemical binding]; other site
889513000831	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
889513000832	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
889513000833	NAD(P) binding site [chemical binding]; other site
889513000834	LDH/MDH dimer interface [polypeptide binding]; other site
889513000835	substrate binding site [chemical binding]; other site
889513000836	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
889513000837	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889513000838	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
889513000839	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
889513000840	substrate binding pocket [chemical binding]; other site
889513000841	chain length determination region; other site
889513000842	substrate-Mg2+ binding site; other site
889513000843	catalytic residues [active]
889513000844	aspartate-rich region 1; other site
889513000845	active site lid residues [active]
889513000846	aspartate-rich region 2; other site
889513000847	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
889513000848	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
889513000849	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
889513000850	putative homodimer interface [polypeptide binding]; other site
889513000851	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
889513000852	heterodimer interface [polypeptide binding]; other site
889513000853	homodimer interface [polypeptide binding]; other site
889513000854	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
889513000855	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
889513000856	23S rRNA interface [nucleotide binding]; other site
889513000857	L7/L12 interface [polypeptide binding]; other site
889513000858	putative thiostrepton binding site; other site
889513000859	L25 interface [polypeptide binding]; other site
889513000860	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
889513000861	mRNA/rRNA interface [nucleotide binding]; other site
889513000862	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
889513000863	trimer interface [polypeptide binding]; other site
889513000864	active site
889513000865	G bulge; other site
889513000866	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889513000867	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
889513000868	FMN binding site [chemical binding]; other site
889513000869	active site
889513000870	substrate binding site [chemical binding]; other site
889513000871	catalytic residue [active]
889513000872	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
889513000873	23S rRNA interface [nucleotide binding]; other site
889513000874	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
889513000875	50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157
889513000876	L11 interface [polypeptide binding]; other site
889513000877	putative EF-Tu interaction site [polypeptide binding]; other site
889513000878	putative EF-G interaction site [polypeptide binding]; other site
889513000879	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513000880	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
889513000881	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513000882	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513000883	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513000884	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513000885	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
889513000886	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
889513000887	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
889513000888	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
889513000889	ABC-ATPase subunit  interface; other site
889513000890	dimer interface [polypeptide binding]; other site
889513000891	putative PBP binding regions; other site
889513000892	Ethylene insensitive 3; Region: EIN3; cl04813
889513000893	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
889513000894	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
889513000895	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
889513000896	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
889513000897	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
889513000898	RPB1 interaction site [polypeptide binding]; other site
889513000899	RPB10 interaction site [polypeptide binding]; other site
889513000900	RPB11 interaction site [polypeptide binding]; other site
889513000901	RPB3 interaction site [polypeptide binding]; other site
889513000902	RPB12 interaction site [polypeptide binding]; other site
889513000903	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
889513000904	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
889513000905	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
889513000906	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
889513000907	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
889513000908	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
889513000909	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
889513000910	G-loop; other site
889513000911	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
889513000912	DNA binding site [nucleotide binding]
889513000913	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
889513000914	Histidine kinase; Region: HisKA_3; pfam07730
889513000915	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
889513000916	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889513000917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513000918	active site
889513000919	phosphorylation site [posttranslational modification]
889513000920	intermolecular recognition site; other site
889513000921	dimerization interface [polypeptide binding]; other site
889513000922	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889513000923	DNA binding residues [nucleotide binding]
889513000924	dimerization interface [polypeptide binding]; other site
889513000925	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
889513000926	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
889513000927	TIGR03943 family protein; Region: TIGR03943
889513000928	Predicted permease; Region: DUF318; cl17795
889513000929	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
889513000930	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513000931	FeS/SAM binding site; other site
889513000932	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
889513000933	Class III ribonucleotide reductase; Region: RNR_III; cd01675
889513000934	effector binding site; other site
889513000935	active site
889513000936	Zn binding site [ion binding]; other site
889513000937	glycine loop; other site
889513000938	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
889513000939	S17 interaction site [polypeptide binding]; other site
889513000940	S8 interaction site; other site
889513000941	16S rRNA interaction site [nucleotide binding]; other site
889513000942	streptomycin interaction site [chemical binding]; other site
889513000943	23S rRNA interaction site [nucleotide binding]; other site
889513000944	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
889513000945	30S ribosomal protein S7; Validated; Region: PRK05302
889513000946	elongation factor G; Reviewed; Region: PRK00007
889513000947	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
889513000948	G1 box; other site
889513000949	putative GEF interaction site [polypeptide binding]; other site
889513000950	GTP/Mg2+ binding site [chemical binding]; other site
889513000951	Switch I region; other site
889513000952	G2 box; other site
889513000953	G3 box; other site
889513000954	Switch II region; other site
889513000955	G4 box; other site
889513000956	G5 box; other site
889513000957	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
889513000958	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
889513000959	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
889513000960	elongation factor Tu; Reviewed; Region: PRK00049
889513000961	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
889513000962	G1 box; other site
889513000963	GEF interaction site [polypeptide binding]; other site
889513000964	GTP/Mg2+ binding site [chemical binding]; other site
889513000965	Switch I region; other site
889513000966	G2 box; other site
889513000967	G3 box; other site
889513000968	Switch II region; other site
889513000969	G4 box; other site
889513000970	G5 box; other site
889513000971	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
889513000972	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
889513000973	Antibiotic Binding Site [chemical binding]; other site
889513000974	Asp23 family; Region: Asp23; cl00574
889513000975	Asp23 family; Region: Asp23; cl00574
889513000976	Asp23 family; Region: Asp23; pfam03780
889513000977	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
889513000978	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
889513000979	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
889513000980	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
889513000981	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
889513000982	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
889513000983	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
889513000984	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
889513000985	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
889513000986	putative translocon binding site; other site
889513000987	protein-rRNA interface [nucleotide binding]; other site
889513000988	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
889513000989	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
889513000990	G-X-X-G motif; other site
889513000991	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
889513000992	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
889513000993	23S rRNA interface [nucleotide binding]; other site
889513000994	5S rRNA interface [nucleotide binding]; other site
889513000995	putative antibiotic binding site [chemical binding]; other site
889513000996	L25 interface [polypeptide binding]; other site
889513000997	L27 interface [polypeptide binding]; other site
889513000998	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
889513000999	putative translocon interaction site; other site
889513001000	23S rRNA interface [nucleotide binding]; other site
889513001001	signal recognition particle (SRP54) interaction site; other site
889513001002	L23 interface [polypeptide binding]; other site
889513001003	trigger factor interaction site; other site
889513001004	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
889513001005	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
889513001006	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
889513001007	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
889513001008	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513001009	Walker A/P-loop; other site
889513001010	ATP binding site [chemical binding]; other site
889513001011	Q-loop/lid; other site
889513001012	ABC transporter signature motif; other site
889513001013	Walker B; other site
889513001014	D-loop; other site
889513001015	H-loop/switch region; other site
889513001016	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513001017	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513001018	Walker A/P-loop; other site
889513001019	ATP binding site [chemical binding]; other site
889513001020	Q-loop/lid; other site
889513001021	ABC transporter signature motif; other site
889513001022	Walker B; other site
889513001023	D-loop; other site
889513001024	H-loop/switch region; other site
889513001025	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513001026	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
889513001027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001028	dimer interface [polypeptide binding]; other site
889513001029	conserved gate region; other site
889513001030	putative PBP binding loops; other site
889513001031	ABC-ATPase subunit interface; other site
889513001032	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513001033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001034	putative PBP binding loops; other site
889513001035	dimer interface [polypeptide binding]; other site
889513001036	ABC-ATPase subunit interface; other site
889513001037	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
889513001038	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
889513001039	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
889513001040	RNA binding site [nucleotide binding]; other site
889513001041	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
889513001042	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
889513001043	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
889513001044	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
889513001045	serine transporter; Region: stp; TIGR00814
889513001046	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
889513001047	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
889513001048	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
889513001049	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
889513001050	active site
889513001051	homotetramer interface [polypeptide binding]; other site
889513001052	homodimer interface [polypeptide binding]; other site
889513001053	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
889513001054	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889513001055	active site
889513001056	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
889513001057	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
889513001058	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
889513001059	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
889513001060	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
889513001061	5S rRNA interface [nucleotide binding]; other site
889513001062	23S rRNA interface [nucleotide binding]; other site
889513001063	L5 interface [polypeptide binding]; other site
889513001064	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
889513001065	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
889513001066	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
889513001067	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
889513001068	23S rRNA binding site [nucleotide binding]; other site
889513001069	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
889513001070	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
889513001071	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
889513001072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001073	dimer interface [polypeptide binding]; other site
889513001074	conserved gate region; other site
889513001075	putative PBP binding loops; other site
889513001076	ABC-ATPase subunit interface; other site
889513001077	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
889513001078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001079	dimer interface [polypeptide binding]; other site
889513001080	conserved gate region; other site
889513001081	putative PBP binding loops; other site
889513001082	ABC-ATPase subunit interface; other site
889513001083	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
889513001084	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
889513001085	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
889513001086	Walker A/P-loop; other site
889513001087	ATP binding site [chemical binding]; other site
889513001088	Q-loop/lid; other site
889513001089	ABC transporter signature motif; other site
889513001090	Walker B; other site
889513001091	D-loop; other site
889513001092	H-loop/switch region; other site
889513001093	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
889513001094	SecY translocase; Region: SecY; pfam00344
889513001095	adenylate kinase; Reviewed; Region: adk; PRK00279
889513001096	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
889513001097	AMP-binding site [chemical binding]; other site
889513001098	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
889513001099	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
889513001100	catalytic site [active]
889513001101	BNR repeat-like domain; Region: BNR_2; pfam13088
889513001102	Asp-box motif; other site
889513001103	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
889513001104	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
889513001105	rRNA binding site [nucleotide binding]; other site
889513001106	predicted 30S ribosome binding site; other site
889513001107	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
889513001108	30S ribosomal protein S13; Region: bact_S13; TIGR03631
889513001109	30S ribosomal protein S11; Validated; Region: PRK05309
889513001110	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
889513001111	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
889513001112	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889513001113	RNA binding surface [nucleotide binding]; other site
889513001114	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
889513001115	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
889513001116	alphaNTD - beta interaction site [polypeptide binding]; other site
889513001117	alphaNTD homodimer interface [polypeptide binding]; other site
889513001118	alphaNTD - beta' interaction site [polypeptide binding]; other site
889513001119	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
889513001120	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
889513001121	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
889513001122	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
889513001123	dimerization interface 3.5A [polypeptide binding]; other site
889513001124	active site
889513001125	Protein of unknown function (DUF690); Region: DUF690; cl04939
889513001126	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
889513001127	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
889513001128	active site
889513001129	catalytic residues [active]
889513001130	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
889513001131	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
889513001132	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
889513001133	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
889513001134	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
889513001135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513001136	Walker A/P-loop; other site
889513001137	ATP binding site [chemical binding]; other site
889513001138	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
889513001139	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
889513001140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
889513001141	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
889513001142	23S rRNA interface [nucleotide binding]; other site
889513001143	L3 interface [polypeptide binding]; other site
889513001144	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
889513001145	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
889513001146	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
889513001147	active site
889513001148	substrate binding site [chemical binding]; other site
889513001149	metal binding site [ion binding]; metal-binding site
889513001150	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
889513001151	alanine racemase; Reviewed; Region: alr; PRK00053
889513001152	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
889513001153	active site
889513001154	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889513001155	dimer interface [polypeptide binding]; other site
889513001156	substrate binding site [chemical binding]; other site
889513001157	catalytic residues [active]
889513001158	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
889513001159	Predicted permease [General function prediction only]; Region: COG2985
889513001160	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
889513001161	TrkA-C domain; Region: TrkA_C; pfam02080
889513001162	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
889513001163	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
889513001164	Glycoprotease family; Region: Peptidase_M22; pfam00814
889513001165	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
889513001166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513001167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
889513001168	Coenzyme A binding pocket [chemical binding]; other site
889513001169	UGMP family protein; Validated; Region: PRK09604
889513001170	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
889513001171	oligomerisation interface [polypeptide binding]; other site
889513001172	mobile loop; other site
889513001173	roof hairpin; other site
889513001174	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
889513001175	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
889513001176	ring oligomerisation interface [polypeptide binding]; other site
889513001177	ATP/Mg binding site [chemical binding]; other site
889513001178	stacking interactions; other site
889513001179	hinge regions; other site
889513001180	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
889513001181	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513001182	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513001183	DNA binding residues [nucleotide binding]
889513001184	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
889513001185	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
889513001186	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
889513001187	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
889513001188	active site
889513001189	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
889513001190	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
889513001191	phosphate binding site [ion binding]; other site
889513001192	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
889513001193	GMP synthase; Reviewed; Region: guaA; PRK00074
889513001194	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
889513001195	AMP/PPi binding site [chemical binding]; other site
889513001196	candidate oxyanion hole; other site
889513001197	catalytic triad [active]
889513001198	potential glutamine specificity residues [chemical binding]; other site
889513001199	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
889513001200	ATP Binding subdomain [chemical binding]; other site
889513001201	Ligand Binding sites [chemical binding]; other site
889513001202	Dimerization subdomain; other site
889513001203	PspC domain; Region: PspC; cl00864
889513001204	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
889513001205	PspC domain; Region: PspC; pfam04024
889513001206	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
889513001207	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
889513001208	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889513001209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513001210	active site
889513001211	phosphorylation site [posttranslational modification]
889513001212	intermolecular recognition site; other site
889513001213	dimerization interface [polypeptide binding]; other site
889513001214	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889513001215	dimerization interface [polypeptide binding]; other site
889513001216	DNA binding residues [nucleotide binding]
889513001217	AMIN domain; Region: AMIN; pfam11741
889513001218	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
889513001219	putative dimer interface [polypeptide binding]; other site
889513001220	putative [2Fe-2S] cluster binding site [ion binding]; other site
889513001221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001222	dimer interface [polypeptide binding]; other site
889513001223	conserved gate region; other site
889513001224	ABC-ATPase subunit interface; other site
889513001225	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
889513001226	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
889513001227	Walker A/P-loop; other site
889513001228	ATP binding site [chemical binding]; other site
889513001229	Q-loop/lid; other site
889513001230	ABC transporter signature motif; other site
889513001231	Walker B; other site
889513001232	D-loop; other site
889513001233	H-loop/switch region; other site
889513001234	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
889513001235	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
889513001236	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
889513001237	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513001238	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
889513001239	intersubunit interface [polypeptide binding]; other site
889513001240	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
889513001241	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
889513001242	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
889513001243	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513001244	ABC-ATPase subunit  interface; other site
889513001245	dimer interface [polypeptide binding]; other site
889513001246	putative PBP binding regions; other site
889513001247	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
889513001248	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
889513001249	ABC-ATPase subunit  interface; other site
889513001250	dimer interface [polypeptide binding]; other site
889513001251	putative PBP binding regions; other site
889513001252	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
889513001253	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
889513001254	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
889513001255	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
889513001256	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
889513001257	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
889513001258	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
889513001259	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
889513001260	homodimer interface [polypeptide binding]; other site
889513001261	NADP binding site [chemical binding]; other site
889513001262	substrate binding site [chemical binding]; other site
889513001263	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
889513001264	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
889513001265	active site
889513001266	Htaa; Region: HtaA; pfam04213
889513001267	Htaa; Region: HtaA; pfam04213
889513001268	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
889513001269	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513001270	intersubunit interface [polypeptide binding]; other site
889513001271	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513001272	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513001273	ABC-ATPase subunit  interface; other site
889513001274	dimer interface [polypeptide binding]; other site
889513001275	putative PBP binding regions; other site
889513001276	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
889513001277	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513001278	Walker A/P-loop; other site
889513001279	ATP binding site [chemical binding]; other site
889513001280	Q-loop/lid; other site
889513001281	ABC transporter signature motif; other site
889513001282	Walker B; other site
889513001283	D-loop; other site
889513001284	H-loop/switch region; other site
889513001285	Htaa; Region: HtaA; pfam04213
889513001286	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
889513001287	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
889513001288	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889513001289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513001290	putative substrate translocation pore; other site
889513001291	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
889513001292	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
889513001293	DNA binding residues [nucleotide binding]
889513001294	dimer interface [polypeptide binding]; other site
889513001295	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
889513001296	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
889513001297	putative catalytic site [active]
889513001298	putative metal binding site [ion binding]; other site
889513001299	putative phosphate binding site [ion binding]; other site
889513001300	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
889513001301	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
889513001302	active site
889513001303	HIGH motif; other site
889513001304	dimer interface [polypeptide binding]; other site
889513001305	KMSKS motif; other site
889513001306	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
889513001307	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
889513001308	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
889513001309	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
889513001310	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513001311	active site
889513001312	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
889513001313	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889513001314	non-specific DNA binding site [nucleotide binding]; other site
889513001315	salt bridge; other site
889513001316	sequence-specific DNA binding site [nucleotide binding]; other site
889513001317	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
889513001318	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
889513001319	active site
889513001320	substrate binding site [chemical binding]; other site
889513001321	metal binding site [ion binding]; metal-binding site
889513001322	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
889513001323	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
889513001324	metal binding site [ion binding]; metal-binding site
889513001325	putative dimer interface [polypeptide binding]; other site
889513001326	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
889513001327	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889513001328	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889513001329	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889513001330	pyruvate carboxylase; Reviewed; Region: PRK12999
889513001331	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889513001332	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889513001333	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
889513001334	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
889513001335	active site
889513001336	catalytic residues [active]
889513001337	metal binding site [ion binding]; metal-binding site
889513001338	homodimer binding site [polypeptide binding]; other site
889513001339	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889513001340	carboxyltransferase (CT) interaction site; other site
889513001341	biotinylation site [posttranslational modification]; other site
889513001342	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513001343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513001344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513001345	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
889513001346	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889513001347	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
889513001348	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
889513001349	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889513001350	carboxyltransferase (CT) interaction site; other site
889513001351	biotinylation site [posttranslational modification]; other site
889513001352	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
889513001353	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
889513001354	active site residue [active]
889513001355	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
889513001356	active site residue [active]
889513001357	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
889513001358	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
889513001359	Maf-like protein; Region: Maf; pfam02545
889513001360	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
889513001361	active site
889513001362	dimer interface [polypeptide binding]; other site
889513001363	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
889513001364	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
889513001365	substrate binding site [chemical binding]; other site
889513001366	ATP binding site [chemical binding]; other site
889513001367	Transcriptional regulators [Transcription]; Region: PurR; COG1609
889513001368	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
889513001369	DNA binding site [nucleotide binding]
889513001370	domain linker motif; other site
889513001371	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
889513001372	putative ligand binding site [chemical binding]; other site
889513001373	dimerization interface [polypeptide binding]; other site
889513001374	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
889513001375	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
889513001376	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
889513001377	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889513001378	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
889513001379	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
889513001380	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889513001381	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
889513001382	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
889513001383	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
889513001384	ATP-grasp domain; Region: ATP-grasp; pfam02222
889513001385	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
889513001386	Uncharacterized conserved protein [Function unknown]; Region: COG1434
889513001387	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
889513001388	putative active site [active]
889513001389	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
889513001390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001391	dimer interface [polypeptide binding]; other site
889513001392	conserved gate region; other site
889513001393	putative PBP binding loops; other site
889513001394	ABC-ATPase subunit interface; other site
889513001395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001396	dimer interface [polypeptide binding]; other site
889513001397	conserved gate region; other site
889513001398	putative PBP binding loops; other site
889513001399	ABC-ATPase subunit interface; other site
889513001400	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
889513001401	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
889513001402	TIGR03089 family protein; Region: TIGR03089
889513001403	Transcriptional regulator [Transcription]; Region: LytR; COG1316
889513001404	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
889513001405	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
889513001406	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
889513001407	Probable Catalytic site; other site
889513001408	metal-binding site
889513001409	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
889513001410	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
889513001411	active site
889513001412	Substrate binding site; other site
889513001413	Mg++ binding site; other site
889513001414	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889513001415	putative trimer interface [polypeptide binding]; other site
889513001416	putative CoA binding site [chemical binding]; other site
889513001417	Transcription factor WhiB; Region: Whib; pfam02467
889513001418	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
889513001419	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
889513001420	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
889513001421	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
889513001422	active site
889513001423	substrate binding site [chemical binding]; other site
889513001424	metal binding site [ion binding]; metal-binding site
889513001425	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
889513001426	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
889513001427	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
889513001428	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
889513001429	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
889513001430	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
889513001431	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
889513001432	homotetramer interface [polypeptide binding]; other site
889513001433	ligand binding site [chemical binding]; other site
889513001434	catalytic site [active]
889513001435	NAD binding site [chemical binding]; other site
889513001436	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
889513001437	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
889513001438	TMP-binding site; other site
889513001439	ATP-binding site [chemical binding]; other site
889513001440	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889513001441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513001442	active site
889513001443	phosphorylation site [posttranslational modification]
889513001444	intermolecular recognition site; other site
889513001445	dimerization interface [polypeptide binding]; other site
889513001446	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889513001447	DNA binding site [nucleotide binding]
889513001448	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889513001449	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889513001450	dimerization interface [polypeptide binding]; other site
889513001451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889513001452	dimer interface [polypeptide binding]; other site
889513001453	phosphorylation site [posttranslational modification]
889513001454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513001455	ATP binding site [chemical binding]; other site
889513001456	Mg2+ binding site [ion binding]; other site
889513001457	G-X-G motif; other site
889513001458	lipoprotein LpqB; Provisional; Region: PRK13616
889513001459	Sporulation and spore germination; Region: Germane; pfam10646
889513001460	comF family protein; Region: comF; TIGR00201
889513001461	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513001462	active site
889513001463	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
889513001464	30S subunit binding site; other site
889513001465	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
889513001466	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
889513001467	ATP binding site [chemical binding]; other site
889513001468	putative Mg++ binding site [ion binding]; other site
889513001469	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
889513001470	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
889513001471	nucleotide binding region [chemical binding]; other site
889513001472	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
889513001473	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
889513001474	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
889513001475	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
889513001476	FAD binding pocket [chemical binding]; other site
889513001477	FAD binding motif [chemical binding]; other site
889513001478	phosphate binding motif [ion binding]; other site
889513001479	beta-alpha-beta structure motif; other site
889513001480	NAD binding pocket [chemical binding]; other site
889513001481	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
889513001482	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889513001483	catalytic loop [active]
889513001484	iron binding site [ion binding]; other site
889513001485	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
889513001486	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
889513001487	putative di-iron ligands [ion binding]; other site
889513001488	Predicted GTPases [General function prediction only]; Region: COG1162
889513001489	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
889513001490	GTPase/Zn-binding domain interface [polypeptide binding]; other site
889513001491	GTP/Mg2+ binding site [chemical binding]; other site
889513001492	G4 box; other site
889513001493	G5 box; other site
889513001494	G1 box; other site
889513001495	Switch I region; other site
889513001496	G2 box; other site
889513001497	G3 box; other site
889513001498	Switch II region; other site
889513001499	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
889513001500	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
889513001501	hinge; other site
889513001502	active site
889513001503	Uncharacterized conserved protein [Function unknown]; Region: COG2135
889513001504	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
889513001505	putative deacylase active site [active]
889513001506	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
889513001507	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513001508	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513001509	DNA binding residues [nucleotide binding]
889513001510	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
889513001511	Transcription factor WhiB; Region: Whib; pfam02467
889513001512	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
889513001513	active site
889513001514	catalytic triad [active]
889513001515	oxyanion hole [active]
889513001516	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
889513001517	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
889513001518	DEAD-like helicases superfamily; Region: DEXDc; smart00487
889513001519	ATP binding site [chemical binding]; other site
889513001520	Mg++ binding site [ion binding]; other site
889513001521	motif III; other site
889513001522	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513001523	nucleotide binding region [chemical binding]; other site
889513001524	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
889513001525	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
889513001526	TIGR02569 family protein; Region: TIGR02569_actnb
889513001527	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
889513001528	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
889513001529	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
889513001530	Part of AAA domain; Region: AAA_19; pfam13245
889513001531	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
889513001532	Ion channel; Region: Ion_trans_2; pfam07885
889513001533	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
889513001534	TrkA-N domain; Region: TrkA_N; pfam02254
889513001535	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
889513001536	putative NADH binding site [chemical binding]; other site
889513001537	putative active site [active]
889513001538	nudix motif; other site
889513001539	putative metal binding site [ion binding]; other site
889513001540	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
889513001541	Part of AAA domain; Region: AAA_19; pfam13245
889513001542	Family description; Region: UvrD_C_2; pfam13538
889513001543	HRDC domain; Region: HRDC; pfam00570
889513001544	Protein of unknown function DUF45; Region: DUF45; cl00636
889513001545	putative hydrolase; Region: TIGR03624
889513001546	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
889513001547	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889513001548	hypothetical protein; Validated; Region: PRK00068
889513001549	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
889513001550	Abi-like protein; Region: Abi_2; pfam07751
889513001551	Predicted helicase [General function prediction only]; Region: COG4889
889513001552	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
889513001553	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513001554	ATP binding site [chemical binding]; other site
889513001555	putative Mg++ binding site [ion binding]; other site
889513001556	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513001557	ATP-binding site [chemical binding]; other site
889513001558	Methyltransferase domain; Region: Methyltransf_26; pfam13659
889513001559	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
889513001560	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
889513001561	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
889513001562	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
889513001563	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
889513001564	Predicted membrane protein [Function unknown]; Region: COG2311
889513001565	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
889513001566	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513001567	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
889513001568	acyl-activating enzyme (AAE) consensus motif; other site
889513001569	AMP binding site [chemical binding]; other site
889513001570	active site
889513001571	CoA binding site [chemical binding]; other site
889513001572	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
889513001573	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
889513001574	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889513001575	putative trimer interface [polypeptide binding]; other site
889513001576	putative CoA binding site [chemical binding]; other site
889513001577	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889513001578	putative trimer interface [polypeptide binding]; other site
889513001579	putative CoA binding site [chemical binding]; other site
889513001580	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889513001581	oxaloacetate decarboxylase; Provisional; Region: PRK12330
889513001582	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
889513001583	active site
889513001584	catalytic residues [active]
889513001585	metal binding site [ion binding]; metal-binding site
889513001586	homodimer binding site [polypeptide binding]; other site
889513001587	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
889513001588	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
889513001589	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889513001590	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889513001591	carboxyltransferase (CT) interaction site; other site
889513001592	biotinylation site [posttranslational modification]; other site
889513001593	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
889513001594	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
889513001595	active site
889513001596	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
889513001597	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
889513001598	active site
889513001599	peptide chain release factor 2; Validated; Region: prfB; PRK00578
889513001600	This domain is found in peptide chain release factors; Region: PCRF; smart00937
889513001601	RF-1 domain; Region: RF-1; pfam00472
889513001602	topology modulation protein; Provisional; Region: PRK07261
889513001603	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
889513001604	active site
889513001605	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
889513001606	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
889513001607	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
889513001608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513001609	Walker A/P-loop; other site
889513001610	ATP binding site [chemical binding]; other site
889513001611	Q-loop/lid; other site
889513001612	ABC transporter signature motif; other site
889513001613	Walker B; other site
889513001614	D-loop; other site
889513001615	H-loop/switch region; other site
889513001616	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
889513001617	FtsX-like permease family; Region: FtsX; pfam02687
889513001618	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
889513001619	SmpB-tmRNA interface; other site
889513001620	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
889513001621	active site clefts [active]
889513001622	zinc binding site [ion binding]; other site
889513001623	dimer interface [polypeptide binding]; other site
889513001624	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
889513001625	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513001626	intersubunit interface [polypeptide binding]; other site
889513001627	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513001628	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513001629	ABC-ATPase subunit  interface; other site
889513001630	dimer interface [polypeptide binding]; other site
889513001631	putative PBP binding regions; other site
889513001632	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513001633	ABC-ATPase subunit  interface; other site
889513001634	dimer interface [polypeptide binding]; other site
889513001635	putative PBP binding regions; other site
889513001636	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
889513001637	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513001638	Walker A/P-loop; other site
889513001639	ATP binding site [chemical binding]; other site
889513001640	Q-loop/lid; other site
889513001641	ABC transporter signature motif; other site
889513001642	Walker B; other site
889513001643	D-loop; other site
889513001644	H-loop/switch region; other site
889513001645	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
889513001646	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
889513001647	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
889513001648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513001649	ATP binding site [chemical binding]; other site
889513001650	putative Mg++ binding site [ion binding]; other site
889513001651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513001652	nucleotide binding region [chemical binding]; other site
889513001653	ATP-binding site [chemical binding]; other site
889513001654	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
889513001655	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
889513001656	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
889513001657	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
889513001658	DNA-binding site [nucleotide binding]; DNA binding site
889513001659	RNA-binding motif; other site
889513001660	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
889513001661	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
889513001662	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
889513001663	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
889513001664	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
889513001665	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
889513001666	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
889513001667	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889513001668	catalytic residue [active]
889513001669	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
889513001670	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
889513001671	dimer interface [polypeptide binding]; other site
889513001672	active site
889513001673	citrylCoA binding site [chemical binding]; other site
889513001674	NADH binding [chemical binding]; other site
889513001675	cationic pore residues; other site
889513001676	oxalacetate/citrate binding site [chemical binding]; other site
889513001677	coenzyme A binding site [chemical binding]; other site
889513001678	catalytic triad [active]
889513001679	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889513001680	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
889513001681	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889513001682	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
889513001683	E-class dimer interface [polypeptide binding]; other site
889513001684	P-class dimer interface [polypeptide binding]; other site
889513001685	active site
889513001686	Cu2+ binding site [ion binding]; other site
889513001687	Zn2+ binding site [ion binding]; other site
889513001688	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
889513001689	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
889513001690	active site
889513001691	catalytic tetrad [active]
889513001692	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
889513001693	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889513001694	substrate binding site [chemical binding]; other site
889513001695	oxyanion hole (OAH) forming residues; other site
889513001696	trimer interface [polypeptide binding]; other site
889513001697	Protein of unknown function, DUF485; Region: DUF485; pfam04341
889513001698	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
889513001699	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
889513001700	Na binding site [ion binding]; other site
889513001701	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
889513001702	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
889513001703	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
889513001704	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
889513001705	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
889513001706	dimer interface [polypeptide binding]; other site
889513001707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513001708	catalytic residue [active]
889513001709	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
889513001710	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889513001711	catalytic residue [active]
889513001712	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
889513001713	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
889513001714	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
889513001715	substrate binding pocket [chemical binding]; other site
889513001716	active site
889513001717	iron coordination sites [ion binding]; other site
889513001718	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
889513001719	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
889513001720	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513001721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001722	dimer interface [polypeptide binding]; other site
889513001723	conserved gate region; other site
889513001724	putative PBP binding loops; other site
889513001725	ABC-ATPase subunit interface; other site
889513001726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
889513001727	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
889513001728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513001729	Walker A/P-loop; other site
889513001730	ATP binding site [chemical binding]; other site
889513001731	Q-loop/lid; other site
889513001732	ABC transporter signature motif; other site
889513001733	Walker B; other site
889513001734	D-loop; other site
889513001735	H-loop/switch region; other site
889513001736	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513001737	Walker A/P-loop; other site
889513001738	ATP binding site [chemical binding]; other site
889513001739	Q-loop/lid; other site
889513001740	ABC transporter signature motif; other site
889513001741	Walker B; other site
889513001742	D-loop; other site
889513001743	H-loop/switch region; other site
889513001744	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
889513001745	active site
889513001746	SAM binding site [chemical binding]; other site
889513001747	homodimer interface [polypeptide binding]; other site
889513001748	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
889513001749	catalytic residues [active]
889513001750	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
889513001751	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
889513001752	folate binding site [chemical binding]; other site
889513001753	NADP+ binding site [chemical binding]; other site
889513001754	thymidylate synthase; Reviewed; Region: thyA; PRK01827
889513001755	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
889513001756	dimerization interface [polypeptide binding]; other site
889513001757	active site
889513001758	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
889513001759	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
889513001760	active site
889513001761	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513001762	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
889513001763	ATP binding site [chemical binding]; other site
889513001764	putative Mg++ binding site [ion binding]; other site
889513001765	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513001766	nucleotide binding region [chemical binding]; other site
889513001767	ATP-binding site [chemical binding]; other site
889513001768	DEAD/H associated; Region: DEAD_assoc; pfam08494
889513001769	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
889513001770	active site
889513001771	SUMO-1 interface [polypeptide binding]; other site
889513001772	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
889513001773	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
889513001774	putative DNA binding site [nucleotide binding]; other site
889513001775	catalytic residue [active]
889513001776	putative H2TH interface [polypeptide binding]; other site
889513001777	putative catalytic residues [active]
889513001778	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
889513001779	hypothetical protein; Provisional; Region: PRK11770
889513001780	Domain of unknown function (DUF307); Region: DUF307; pfam03733
889513001781	Domain of unknown function (DUF307); Region: DUF307; pfam03733
889513001782	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
889513001783	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
889513001784	active site
889513001785	dimer interface [polypeptide binding]; other site
889513001786	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
889513001787	dimer interface [polypeptide binding]; other site
889513001788	active site
889513001789	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889513001790	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
889513001791	tetramerization interface [polypeptide binding]; other site
889513001792	NAD(P) binding site [chemical binding]; other site
889513001793	catalytic residues [active]
889513001794	hypothetical protein; Provisional; Region: PRK07857
889513001795	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
889513001796	Part of AAA domain; Region: AAA_19; pfam13245
889513001797	Family description; Region: UvrD_C_2; pfam13538
889513001798	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889513001799	Peptidase family M23; Region: Peptidase_M23; pfam01551
889513001800	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
889513001801	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
889513001802	active site
889513001803	substrate binding site [chemical binding]; other site
889513001804	cosubstrate binding site; other site
889513001805	catalytic site [active]
889513001806	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
889513001807	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
889513001808	purine monophosphate binding site [chemical binding]; other site
889513001809	dimer interface [polypeptide binding]; other site
889513001810	putative catalytic residues [active]
889513001811	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
889513001812	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
889513001813	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
889513001814	Walker A/P-loop; other site
889513001815	ATP binding site [chemical binding]; other site
889513001816	Q-loop/lid; other site
889513001817	ABC transporter signature motif; other site
889513001818	Walker B; other site
889513001819	D-loop; other site
889513001820	H-loop/switch region; other site
889513001821	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
889513001822	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889513001823	substrate binding pocket [chemical binding]; other site
889513001824	membrane-bound complex binding site; other site
889513001825	hinge residues; other site
889513001826	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
889513001827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001828	dimer interface [polypeptide binding]; other site
889513001829	conserved gate region; other site
889513001830	putative PBP binding loops; other site
889513001831	ABC-ATPase subunit interface; other site
889513001832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513001833	dimer interface [polypeptide binding]; other site
889513001834	conserved gate region; other site
889513001835	putative PBP binding loops; other site
889513001836	ABC-ATPase subunit interface; other site
889513001837	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
889513001838	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513001839	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513001840	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
889513001841	30S ribosomal protein S18; Provisional; Region: PRK13401
889513001842	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
889513001843	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
889513001844	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
889513001845	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
889513001846	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
889513001847	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889513001848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513001849	active site
889513001850	phosphorylation site [posttranslational modification]
889513001851	intermolecular recognition site; other site
889513001852	dimerization interface [polypeptide binding]; other site
889513001853	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889513001854	DNA binding site [nucleotide binding]
889513001855	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889513001856	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889513001857	dimerization interface [polypeptide binding]; other site
889513001858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889513001859	dimer interface [polypeptide binding]; other site
889513001860	phosphorylation site [posttranslational modification]
889513001861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513001862	ATP binding site [chemical binding]; other site
889513001863	Mg2+ binding site [ion binding]; other site
889513001864	G-X-G motif; other site
889513001865	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
889513001866	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
889513001867	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889513001868	protein binding site [polypeptide binding]; other site
889513001869	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
889513001870	MPT binding site; other site
889513001871	trimer interface [polypeptide binding]; other site
889513001872	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
889513001873	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
889513001874	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
889513001875	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
889513001876	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
889513001877	active site
889513001878	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
889513001879	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
889513001880	dimer interface [polypeptide binding]; other site
889513001881	putative functional site; other site
889513001882	putative MPT binding site; other site
889513001883	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
889513001884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513001885	Coenzyme A binding pocket [chemical binding]; other site
889513001886	Predicted membrane protein [Function unknown]; Region: COG2259
889513001887	Predicted integral membrane protein [Function unknown]; Region: COG5660
889513001888	Putative zinc-finger; Region: zf-HC2; pfam13490
889513001889	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
889513001890	BCCT family transporter; Region: BCCT; pfam02028
889513001891	Uncharacterized membrane protein [Function unknown]; Region: COG3949
889513001892	Predicted methyltransferases [General function prediction only]; Region: COG0313
889513001893	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
889513001894	putative SAM binding site [chemical binding]; other site
889513001895	putative homodimer interface [polypeptide binding]; other site
889513001896	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
889513001897	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
889513001898	active site
889513001899	HIGH motif; other site
889513001900	KMSKS motif; other site
889513001901	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
889513001902	tRNA binding surface [nucleotide binding]; other site
889513001903	anticodon binding site; other site
889513001904	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
889513001905	active site
889513001906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
889513001907	Domain of unknown function (DUF348); Region: DUF348; pfam03990
889513001908	Domain of unknown function (DUF348); Region: DUF348; pfam03990
889513001909	G5 domain; Region: G5; pfam07501
889513001910	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
889513001911	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
889513001912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513001913	S-adenosylmethionine binding site [chemical binding]; other site
889513001914	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
889513001915	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
889513001916	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513001917	ABC transporter; Region: ABC_tran_2; pfam12848
889513001918	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513001919	Uncharacterized conserved protein [Function unknown]; Region: COG1359
889513001920	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
889513001921	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
889513001922	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
889513001923	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889513001924	substrate binding site [chemical binding]; other site
889513001925	oxyanion hole (OAH) forming residues; other site
889513001926	trimer interface [polypeptide binding]; other site
889513001927	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
889513001928	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
889513001929	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
889513001930	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
889513001931	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
889513001932	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
889513001933	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
889513001934	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
889513001935	G1 box; other site
889513001936	putative GEF interaction site [polypeptide binding]; other site
889513001937	GTP/Mg2+ binding site [chemical binding]; other site
889513001938	Switch I region; other site
889513001939	G2 box; other site
889513001940	G3 box; other site
889513001941	Switch II region; other site
889513001942	G4 box; other site
889513001943	G5 box; other site
889513001944	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
889513001945	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513001946	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
889513001947	NAD(P) binding site [chemical binding]; other site
889513001948	active site
889513001949	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
889513001950	putative active site [active]
889513001951	catalytic residue [active]
889513001952	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
889513001953	FMN binding site [chemical binding]; other site
889513001954	substrate binding site [chemical binding]; other site
889513001955	putative catalytic residue [active]
889513001956	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
889513001957	putative active site [active]
889513001958	catalytic residue [active]
889513001959	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
889513001960	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
889513001961	5S rRNA interface [nucleotide binding]; other site
889513001962	CTC domain interface [polypeptide binding]; other site
889513001963	L16 interface [polypeptide binding]; other site
889513001964	pullulanase, type I; Region: pulA_typeI; TIGR02104
889513001965	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
889513001966	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
889513001967	Ca binding site [ion binding]; other site
889513001968	active site
889513001969	catalytic site [active]
889513001970	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
889513001971	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
889513001972	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513001973	active site
889513001974	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
889513001975	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
889513001976	Substrate binding site; other site
889513001977	Mg++ binding site; other site
889513001978	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
889513001979	active site
889513001980	substrate binding site [chemical binding]; other site
889513001981	CoA binding site [chemical binding]; other site
889513001982	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
889513001983	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
889513001984	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
889513001985	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
889513001986	gating phenylalanine in ion channel; other site
889513001987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513001988	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513001989	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
889513001990	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
889513001991	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513001992	ATP binding site [chemical binding]; other site
889513001993	putative Mg++ binding site [ion binding]; other site
889513001994	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513001995	nucleotide binding region [chemical binding]; other site
889513001996	ATP-binding site [chemical binding]; other site
889513001997	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
889513001998	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
889513001999	Spore germination protein; Region: Spore_permease; cl17796
889513002000	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
889513002001	homodimer interface [polypeptide binding]; other site
889513002002	metal binding site [ion binding]; metal-binding site
889513002003	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889513002004	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889513002005	enolase; Provisional; Region: eno; PRK00077
889513002006	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
889513002007	dimer interface [polypeptide binding]; other site
889513002008	metal binding site [ion binding]; metal-binding site
889513002009	substrate binding pocket [chemical binding]; other site
889513002010	Septum formation initiator; Region: DivIC; pfam04977
889513002011	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
889513002012	Uncharacterized conserved protein [Function unknown]; Region: COG1507
889513002013	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
889513002014	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
889513002015	Helix-turn-helix domain; Region: HTH_18; pfam12833
889513002016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889513002017	Bax inhibitor 1 like; Region: BaxI_1; cl17691
889513002018	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
889513002019	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
889513002020	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
889513002021	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
889513002022	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
889513002023	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
889513002024	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
889513002025	catalytic residue [active]
889513002026	putative FPP diphosphate  binding site; other site
889513002027	putative FPP binding hydrophobic cleft; other site
889513002028	dimer interface [polypeptide binding]; other site
889513002029	putative IPP diphosphate binding site; other site
889513002030	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
889513002031	pantothenate kinase; Provisional; Region: PRK05439
889513002032	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
889513002033	ATP-binding site [chemical binding]; other site
889513002034	CoA-binding site [chemical binding]; other site
889513002035	Mg2+-binding site [ion binding]; other site
889513002036	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
889513002037	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
889513002038	dimer interface [polypeptide binding]; other site
889513002039	active site
889513002040	glycine-pyridoxal phosphate binding site [chemical binding]; other site
889513002041	folate binding site [chemical binding]; other site
889513002042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513002043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513002044	putative substrate translocation pore; other site
889513002045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513002046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513002047	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889513002048	dimerization interface [polypeptide binding]; other site
889513002049	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889513002050	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
889513002051	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
889513002052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513002053	Coenzyme A binding pocket [chemical binding]; other site
889513002054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513002055	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
889513002056	putative substrate translocation pore; other site
889513002057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513002058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513002059	fumarate hydratase; Reviewed; Region: fumC; PRK00485
889513002060	Class II fumarases; Region: Fumarase_classII; cd01362
889513002061	active site
889513002062	tetramer interface [polypeptide binding]; other site
889513002063	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
889513002064	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
889513002065	putative active site [active]
889513002066	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
889513002067	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
889513002068	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
889513002069	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
889513002070	generic binding surface II; other site
889513002071	generic binding surface I; other site
889513002072	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
889513002073	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
889513002074	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889513002075	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
889513002076	Domain of unknown function DUF20; Region: UPF0118; pfam01594
889513002077	GTP-binding protein YchF; Reviewed; Region: PRK09601
889513002078	YchF GTPase; Region: YchF; cd01900
889513002079	G1 box; other site
889513002080	GTP/Mg2+ binding site [chemical binding]; other site
889513002081	Switch I region; other site
889513002082	G2 box; other site
889513002083	Switch II region; other site
889513002084	G3 box; other site
889513002085	G4 box; other site
889513002086	G5 box; other site
889513002087	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
889513002088	Protein of unknown function, DUF488; Region: DUF488; pfam04343
889513002089	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
889513002090	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
889513002091	PhnA protein; Region: PhnA; pfam03831
889513002092	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
889513002093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889513002094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002095	Walker A/P-loop; other site
889513002096	ATP binding site [chemical binding]; other site
889513002097	Q-loop/lid; other site
889513002098	ABC transporter signature motif; other site
889513002099	Walker B; other site
889513002100	D-loop; other site
889513002101	H-loop/switch region; other site
889513002102	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
889513002103	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889513002104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002105	Walker A/P-loop; other site
889513002106	ATP binding site [chemical binding]; other site
889513002107	Q-loop/lid; other site
889513002108	ABC transporter signature motif; other site
889513002109	Walker B; other site
889513002110	D-loop; other site
889513002111	H-loop/switch region; other site
889513002112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002113	Walker A/P-loop; other site
889513002114	ATP binding site [chemical binding]; other site
889513002115	Q-loop/lid; other site
889513002116	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
889513002117	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002118	Walker A/P-loop; other site
889513002119	ATP binding site [chemical binding]; other site
889513002120	Q-loop/lid; other site
889513002121	ABC transporter; Region: ABC_tran; pfam00005
889513002122	ABC transporter signature motif; other site
889513002123	Walker B; other site
889513002124	D-loop; other site
889513002125	H-loop/switch region; other site
889513002126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
889513002127	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
889513002128	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
889513002129	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
889513002130	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
889513002131	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
889513002132	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
889513002133	Walker A/P-loop; other site
889513002134	ATP binding site [chemical binding]; other site
889513002135	Q-loop/lid; other site
889513002136	ABC transporter signature motif; other site
889513002137	Walker B; other site
889513002138	D-loop; other site
889513002139	H-loop/switch region; other site
889513002140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002141	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
889513002142	Walker A/P-loop; other site
889513002143	ATP binding site [chemical binding]; other site
889513002144	Q-loop/lid; other site
889513002145	ABC transporter signature motif; other site
889513002146	Walker B; other site
889513002147	D-loop; other site
889513002148	H-loop/switch region; other site
889513002149	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
889513002150	hypothetical protein; Provisional; Region: PRK06547
889513002151	Predicted kinase [General function prediction only]; Region: COG0645
889513002152	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
889513002153	nudix motif; other site
889513002154	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
889513002155	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
889513002156	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513002157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513002158	dimer interface [polypeptide binding]; other site
889513002159	conserved gate region; other site
889513002160	ABC-ATPase subunit interface; other site
889513002161	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
889513002162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513002163	dimer interface [polypeptide binding]; other site
889513002164	conserved gate region; other site
889513002165	putative PBP binding loops; other site
889513002166	ABC-ATPase subunit interface; other site
889513002167	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
889513002168	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513002169	Walker A/P-loop; other site
889513002170	ATP binding site [chemical binding]; other site
889513002171	Q-loop/lid; other site
889513002172	ABC transporter signature motif; other site
889513002173	Walker B; other site
889513002174	D-loop; other site
889513002175	H-loop/switch region; other site
889513002176	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513002177	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513002178	Walker A/P-loop; other site
889513002179	ATP binding site [chemical binding]; other site
889513002180	Q-loop/lid; other site
889513002181	ABC transporter signature motif; other site
889513002182	Walker B; other site
889513002183	D-loop; other site
889513002184	H-loop/switch region; other site
889513002185	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513002186	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
889513002187	cleavage site
889513002188	active site
889513002189	substrate binding sites [chemical binding]; other site
889513002190	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
889513002191	ArsC family; Region: ArsC; pfam03960
889513002192	catalytic residues [active]
889513002193	Protein of unknown function (DUF402); Region: DUF402; cl00979
889513002194	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
889513002195	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
889513002196	G1 box; other site
889513002197	GTP/Mg2+ binding site [chemical binding]; other site
889513002198	G2 box; other site
889513002199	Switch I region; other site
889513002200	G3 box; other site
889513002201	Switch II region; other site
889513002202	G4 box; other site
889513002203	G5 box; other site
889513002204	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
889513002205	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
889513002206	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
889513002207	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
889513002208	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
889513002209	Ferredoxin [Energy production and conversion]; Region: COG1146
889513002210	4Fe-4S binding domain; Region: Fer4; pfam00037
889513002211	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
889513002212	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513002213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513002214	homodimer interface [polypeptide binding]; other site
889513002215	catalytic residue [active]
889513002216	Predicted membrane protein [Function unknown]; Region: COG2246
889513002217	GtrA-like protein; Region: GtrA; pfam04138
889513002218	Domain of unknown function (DUF222); Region: DUF222; pfam02720
889513002219	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
889513002220	active site
889513002221	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889513002222	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
889513002223	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
889513002224	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
889513002225	putative trimer interface [polypeptide binding]; other site
889513002226	putative CoA binding site [chemical binding]; other site
889513002227	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889513002228	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
889513002229	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
889513002230	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889513002231	putative trimer interface [polypeptide binding]; other site
889513002232	putative CoA binding site [chemical binding]; other site
889513002233	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
889513002234	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
889513002235	metal binding site [ion binding]; metal-binding site
889513002236	putative dimer interface [polypeptide binding]; other site
889513002237	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
889513002238	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
889513002239	dihydropteroate synthase; Region: DHPS; TIGR01496
889513002240	substrate binding pocket [chemical binding]; other site
889513002241	dimer interface [polypeptide binding]; other site
889513002242	inhibitor binding site; inhibition site
889513002243	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
889513002244	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
889513002245	Ligand binding site; other site
889513002246	Putative Catalytic site; other site
889513002247	DXD motif; other site
889513002248	DivIVA domain; Region: DivI1A_domain; TIGR03544
889513002249	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
889513002250	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
889513002251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002252	S-adenosylmethionine binding site [chemical binding]; other site
889513002253	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
889513002254	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
889513002255	active site
889513002256	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
889513002257	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
889513002258	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
889513002259	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
889513002260	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
889513002261	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
889513002262	ligand binding site; other site
889513002263	oligomer interface; other site
889513002264	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
889513002265	dimer interface [polypeptide binding]; other site
889513002266	N-terminal domain interface [polypeptide binding]; other site
889513002267	sulfate 1 binding site; other site
889513002268	Methyltransferase domain; Region: Methyltransf_24; pfam13578
889513002269	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
889513002270	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513002271	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513002272	DNA binding residues [nucleotide binding]
889513002273	sec-independent translocase; Provisional; Region: tatB; PRK00182
889513002274	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
889513002275	Domain of unknown function DUF59; Region: DUF59; pfam01883
889513002276	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
889513002277	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
889513002278	Predicted membrane protein [Function unknown]; Region: COG4420
889513002279	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
889513002280	MgtE intracellular N domain; Region: MgtE_N; smart00924
889513002281	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
889513002282	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
889513002283	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
889513002284	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
889513002285	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
889513002286	TPP-binding site [chemical binding]; other site
889513002287	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
889513002288	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
889513002289	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889513002290	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002291	Walker A/P-loop; other site
889513002292	ATP binding site [chemical binding]; other site
889513002293	Q-loop/lid; other site
889513002294	ABC transporter signature motif; other site
889513002295	Walker B; other site
889513002296	D-loop; other site
889513002297	H-loop/switch region; other site
889513002298	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
889513002299	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889513002300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002301	Walker A/P-loop; other site
889513002302	ATP binding site [chemical binding]; other site
889513002303	Q-loop/lid; other site
889513002304	ABC transporter signature motif; other site
889513002305	Walker B; other site
889513002306	D-loop; other site
889513002307	H-loop/switch region; other site
889513002308	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
889513002309	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
889513002310	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
889513002311	shikimate binding site; other site
889513002312	NAD(P) binding site [chemical binding]; other site
889513002313	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
889513002314	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
889513002315	substrate binding pocket [chemical binding]; other site
889513002316	catalytic triad [active]
889513002317	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
889513002318	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
889513002319	active site
889513002320	catalytic residues [active]
889513002321	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
889513002322	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
889513002323	Na binding site [ion binding]; other site
889513002324	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
889513002325	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
889513002326	nucleotide binding site/active site [active]
889513002327	HIT family signature motif; other site
889513002328	catalytic residue [active]
889513002329	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
889513002330	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
889513002331	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
889513002332	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
889513002333	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
889513002334	ATP binding site [chemical binding]; other site
889513002335	Mg++ binding site [ion binding]; other site
889513002336	motif III; other site
889513002337	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513002338	nucleotide binding region [chemical binding]; other site
889513002339	ATP-binding site [chemical binding]; other site
889513002340	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
889513002341	putative RNA binding site [nucleotide binding]; other site
889513002342	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
889513002343	dimer interface [polypeptide binding]; other site
889513002344	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889513002345	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
889513002346	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
889513002347	Na binding site [ion binding]; other site
889513002348	SNF2 Helicase protein; Region: DUF3670; pfam12419
889513002349	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
889513002350	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513002351	ATP binding site [chemical binding]; other site
889513002352	putative Mg++ binding site [ion binding]; other site
889513002353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513002354	nucleotide binding region [chemical binding]; other site
889513002355	ATP-binding site [chemical binding]; other site
889513002356	Uncharacterized conserved protein [Function unknown]; Region: COG4279
889513002357	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
889513002358	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
889513002359	active site
889513002360	metal binding site [ion binding]; metal-binding site
889513002361	DNA binding site [nucleotide binding]
889513002362	AAA domain; Region: AAA_23; pfam13476
889513002363	Uncharacterized conserved protein [Function unknown]; Region: COG2353
889513002364	Transcriptional regulators [Transcription]; Region: MarR; COG1846
889513002365	MarR family; Region: MarR_2; pfam12802
889513002366	PspC domain; Region: PspC; pfam04024
889513002367	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
889513002368	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
889513002369	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
889513002370	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
889513002371	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
889513002372	Cysteine-rich domain; Region: CCG; pfam02754
889513002373	Cysteine-rich domain; Region: CCG; pfam02754
889513002374	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
889513002375	L-lactate permease; Region: Lactate_perm; cl00701
889513002376	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
889513002377	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
889513002378	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
889513002379	active site
889513002380	HIGH motif; other site
889513002381	KMSK motif region; other site
889513002382	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
889513002383	tRNA binding surface [nucleotide binding]; other site
889513002384	anticodon binding site; other site
889513002385	diaminopimelate decarboxylase; Region: lysA; TIGR01048
889513002386	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
889513002387	active site
889513002388	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889513002389	substrate binding site [chemical binding]; other site
889513002390	catalytic residues [active]
889513002391	dimer interface [polypeptide binding]; other site
889513002392	homoserine dehydrogenase; Provisional; Region: PRK06349
889513002393	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
889513002394	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
889513002395	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
889513002396	homoserine kinase; Provisional; Region: PRK01212
889513002397	Predicted transcriptional regulator [Transcription]; Region: COG2345
889513002398	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
889513002399	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
889513002400	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513002401	acyl-activating enzyme (AAE) consensus motif; other site
889513002402	AMP binding site [chemical binding]; other site
889513002403	active site
889513002404	CoA binding site [chemical binding]; other site
889513002405	transcription termination factor Rho; Provisional; Region: PRK12678
889513002406	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
889513002407	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
889513002408	RNA binding site [nucleotide binding]; other site
889513002409	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
889513002410	multimer interface [polypeptide binding]; other site
889513002411	Walker A motif; other site
889513002412	ATP binding site [chemical binding]; other site
889513002413	Walker B motif; other site
889513002414	peptide chain release factor 1; Validated; Region: prfA; PRK00591
889513002415	This domain is found in peptide chain release factors; Region: PCRF; smart00937
889513002416	RF-1 domain; Region: RF-1; pfam00472
889513002417	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
889513002418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002419	S-adenosylmethionine binding site [chemical binding]; other site
889513002420	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
889513002421	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
889513002422	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
889513002423	Mg++ binding site [ion binding]; other site
889513002424	putative catalytic motif [active]
889513002425	substrate binding site [chemical binding]; other site
889513002426	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
889513002427	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
889513002428	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
889513002429	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
889513002430	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
889513002431	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
889513002432	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
889513002433	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
889513002434	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
889513002435	beta subunit interaction interface [polypeptide binding]; other site
889513002436	Walker A motif; other site
889513002437	ATP binding site [chemical binding]; other site
889513002438	Walker B motif; other site
889513002439	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
889513002440	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
889513002441	core domain interface [polypeptide binding]; other site
889513002442	delta subunit interface [polypeptide binding]; other site
889513002443	epsilon subunit interface [polypeptide binding]; other site
889513002444	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
889513002445	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
889513002446	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
889513002447	alpha subunit interaction interface [polypeptide binding]; other site
889513002448	Walker A motif; other site
889513002449	ATP binding site [chemical binding]; other site
889513002450	Walker B motif; other site
889513002451	inhibitor binding site; inhibition site
889513002452	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
889513002453	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
889513002454	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
889513002455	gamma subunit interface [polypeptide binding]; other site
889513002456	epsilon subunit interface [polypeptide binding]; other site
889513002457	LBP interface [polypeptide binding]; other site
889513002458	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
889513002459	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
889513002460	hypothetical protein; Provisional; Region: PRK03298
889513002461	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
889513002462	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889513002463	dimer interface [polypeptide binding]; other site
889513002464	substrate binding site [chemical binding]; other site
889513002465	metal binding site [ion binding]; metal-binding site
889513002466	Domain of unknown function DUF77; Region: DUF77; pfam01910
889513002467	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
889513002468	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
889513002469	glycogen branching enzyme; Provisional; Region: PRK05402
889513002470	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
889513002471	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
889513002472	active site
889513002473	catalytic site [active]
889513002474	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
889513002475	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
889513002476	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
889513002477	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
889513002478	active site
889513002479	catalytic site [active]
889513002480	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513002481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513002482	Walker A/P-loop; other site
889513002483	ATP binding site [chemical binding]; other site
889513002484	ABC transporter signature motif; other site
889513002485	Walker B; other site
889513002486	D-loop; other site
889513002487	H-loop/switch region; other site
889513002488	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
889513002489	Ligand binding site [chemical binding]; other site
889513002490	Electron transfer flavoprotein domain; Region: ETF; pfam01012
889513002491	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
889513002492	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
889513002493	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
889513002494	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
889513002495	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
889513002496	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889513002497	catalytic residue [active]
889513002498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002499	S-adenosylmethionine binding site [chemical binding]; other site
889513002500	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
889513002501	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
889513002502	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
889513002503	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
889513002504	active site
889513002505	catalytic site [active]
889513002506	substrate binding site [chemical binding]; other site
889513002507	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
889513002508	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
889513002509	nucleotide binding pocket [chemical binding]; other site
889513002510	K-X-D-G motif; other site
889513002511	catalytic site [active]
889513002512	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
889513002513	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
889513002514	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
889513002515	Dimer interface [polypeptide binding]; other site
889513002516	BRCT sequence motif; other site
889513002517	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
889513002518	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
889513002519	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
889513002520	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
889513002521	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
889513002522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513002523	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513002524	putative substrate translocation pore; other site
889513002525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513002526	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513002527	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513002528	ABC-ATPase subunit  interface; other site
889513002529	dimer interface [polypeptide binding]; other site
889513002530	putative PBP binding regions; other site
889513002531	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513002532	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513002533	Walker A/P-loop; other site
889513002534	ATP binding site [chemical binding]; other site
889513002535	Q-loop/lid; other site
889513002536	ABC transporter signature motif; other site
889513002537	Walker B; other site
889513002538	D-loop; other site
889513002539	H-loop/switch region; other site
889513002540	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
889513002541	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
889513002542	putative ligand binding residues [chemical binding]; other site
889513002543	6-phosphofructokinase; Provisional; Region: PRK03202
889513002544	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
889513002545	active site
889513002546	ADP/pyrophosphate binding site [chemical binding]; other site
889513002547	dimerization interface [polypeptide binding]; other site
889513002548	allosteric effector site; other site
889513002549	fructose-1,6-bisphosphate binding site; other site
889513002550	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
889513002551	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
889513002552	GatB domain; Region: GatB_Yqey; smart00845
889513002553	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
889513002554	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
889513002555	active site
889513002556	catalytic tetrad [active]
889513002557	Lysine efflux permease [General function prediction only]; Region: COG1279
889513002558	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
889513002559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889513002560	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889513002561	dimerization interface [polypeptide binding]; other site
889513002562	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
889513002563	Predicted membrane protein [Function unknown]; Region: COG2259
889513002564	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
889513002565	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
889513002566	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
889513002567	Mechanosensitive ion channel; Region: MS_channel; pfam00924
889513002568	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
889513002569	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
889513002570	putative valine binding site [chemical binding]; other site
889513002571	dimer interface [polypeptide binding]; other site
889513002572	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
889513002573	ketol-acid reductoisomerase; Provisional; Region: PRK05479
889513002574	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
889513002575	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
889513002576	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
889513002577	Uncharacterized conserved protein [Function unknown]; Region: COG1479
889513002578	Protein of unknown function DUF262; Region: DUF262; pfam03235
889513002579	Uncharacterized conserved protein [Function unknown]; Region: COG3472
889513002580	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
889513002581	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
889513002582	ligand binding site [chemical binding]; other site
889513002583	NAD binding site [chemical binding]; other site
889513002584	dimerization interface [polypeptide binding]; other site
889513002585	catalytic site [active]
889513002586	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
889513002587	putative L-serine binding site [chemical binding]; other site
889513002588	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
889513002589	tartrate dehydrogenase; Region: TTC; TIGR02089
889513002590	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
889513002591	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
889513002592	ligand binding site [chemical binding]; other site
889513002593	flexible hinge region; other site
889513002594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
889513002595	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889513002596	metal binding triad; other site
889513002597	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
889513002598	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
889513002599	active site
889513002600	catalytic site [active]
889513002601	substrate binding site [chemical binding]; other site
889513002602	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
889513002603	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
889513002604	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
889513002605	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
889513002606	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
889513002607	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513002608	HIGH motif; other site
889513002609	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
889513002610	active site
889513002611	KMSKS motif; other site
889513002612	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
889513002613	biotin synthase; Region: bioB; TIGR00433
889513002614	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513002615	FeS/SAM binding site; other site
889513002616	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
889513002617	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
889513002618	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889513002619	Zn2+ binding site [ion binding]; other site
889513002620	Mg2+ binding site [ion binding]; other site
889513002621	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
889513002622	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889513002623	Bacterial transcriptional regulator; Region: IclR; pfam01614
889513002624	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
889513002625	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
889513002626	substrate binding site [chemical binding]; other site
889513002627	ligand binding site [chemical binding]; other site
889513002628	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
889513002629	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
889513002630	substrate binding site [chemical binding]; other site
889513002631	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
889513002632	active site
889513002633	Ap6A binding site [chemical binding]; other site
889513002634	nudix motif; other site
889513002635	metal binding site [ion binding]; metal-binding site
889513002636	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889513002637	catalytic core [active]
889513002638	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
889513002639	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
889513002640	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
889513002641	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
889513002642	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
889513002643	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889513002644	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
889513002645	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
889513002646	thiamine monophosphate kinase; Provisional; Region: PRK05731
889513002647	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
889513002648	ATP binding site [chemical binding]; other site
889513002649	dimerization interface [polypeptide binding]; other site
889513002650	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
889513002651	ligand binding site [chemical binding]; other site
889513002652	active site
889513002653	UGI interface [polypeptide binding]; other site
889513002654	catalytic site [active]
889513002655	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
889513002656	DAK2 domain; Region: Dak2; pfam02734
889513002657	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
889513002658	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
889513002659	generic binding surface II; other site
889513002660	ssDNA binding site; other site
889513002661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513002662	ATP binding site [chemical binding]; other site
889513002663	putative Mg++ binding site [ion binding]; other site
889513002664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513002665	nucleotide binding region [chemical binding]; other site
889513002666	ATP-binding site [chemical binding]; other site
889513002667	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
889513002668	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889513002669	carboxyltransferase (CT) interaction site; other site
889513002670	biotinylation site [posttranslational modification]; other site
889513002671	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
889513002672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002673	S-adenosylmethionine binding site [chemical binding]; other site
889513002674	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
889513002675	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
889513002676	active site
889513002677	(T/H)XGH motif; other site
889513002678	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889513002679	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
889513002680	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
889513002681	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
889513002682	Walker A/P-loop; other site
889513002683	ATP binding site [chemical binding]; other site
889513002684	Q-loop/lid; other site
889513002685	ABC transporter signature motif; other site
889513002686	Walker B; other site
889513002687	D-loop; other site
889513002688	H-loop/switch region; other site
889513002689	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
889513002690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513002691	dimer interface [polypeptide binding]; other site
889513002692	conserved gate region; other site
889513002693	putative PBP binding loops; other site
889513002694	ABC-ATPase subunit interface; other site
889513002695	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889513002696	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
889513002697	substrate binding pocket [chemical binding]; other site
889513002698	membrane-bound complex binding site; other site
889513002699	hinge residues; other site
889513002700	Domain of unknown function (DUF368); Region: DUF368; pfam04018
889513002701	DNA polymerase I; Provisional; Region: PRK05755
889513002702	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
889513002703	active site
889513002704	metal binding site 1 [ion binding]; metal-binding site
889513002705	putative 5' ssDNA interaction site; other site
889513002706	metal binding site 3; metal-binding site
889513002707	metal binding site 2 [ion binding]; metal-binding site
889513002708	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
889513002709	putative DNA binding site [nucleotide binding]; other site
889513002710	putative metal binding site [ion binding]; other site
889513002711	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
889513002712	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
889513002713	active site
889513002714	DNA binding site [nucleotide binding]
889513002715	catalytic site [active]
889513002716	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
889513002717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002718	S-adenosylmethionine binding site [chemical binding]; other site
889513002719	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
889513002720	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
889513002721	RNA binding site [nucleotide binding]; other site
889513002722	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
889513002723	RNA binding site [nucleotide binding]; other site
889513002724	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
889513002725	RNA binding site [nucleotide binding]; other site
889513002726	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
889513002727	RNA binding site [nucleotide binding]; other site
889513002728	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
889513002729	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
889513002730	active site turn [active]
889513002731	phosphorylation site [posttranslational modification]
889513002732	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
889513002733	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
889513002734	HPr interaction site; other site
889513002735	glycerol kinase (GK) interaction site [polypeptide binding]; other site
889513002736	active site
889513002737	phosphorylation site [posttranslational modification]
889513002738	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
889513002739	ATP-binding [chemical binding]; other site
889513002740	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
889513002741	CoA-binding site [chemical binding]; other site
889513002742	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
889513002743	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513002744	FeS/SAM binding site; other site
889513002745	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
889513002746	excinuclease ABC subunit B; Provisional; Region: PRK05298
889513002747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513002748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513002749	nucleotide binding region [chemical binding]; other site
889513002750	ATP-binding site [chemical binding]; other site
889513002751	Ultra-violet resistance protein B; Region: UvrB; pfam12344
889513002752	UvrB/uvrC motif; Region: UVR; pfam02151
889513002753	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889513002754	Ligand Binding Site [chemical binding]; other site
889513002755	Predicted membrane protein [Function unknown]; Region: COG2259
889513002756	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
889513002757	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
889513002758	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
889513002759	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
889513002760	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
889513002761	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
889513002762	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
889513002763	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
889513002764	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
889513002765	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
889513002766	23S rRNA binding site [nucleotide binding]; other site
889513002767	L21 binding site [polypeptide binding]; other site
889513002768	L13 binding site [polypeptide binding]; other site
889513002769	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
889513002770	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
889513002771	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
889513002772	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
889513002773	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
889513002774	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
889513002775	dimer interface [polypeptide binding]; other site
889513002776	motif 1; other site
889513002777	active site
889513002778	motif 2; other site
889513002779	motif 3; other site
889513002780	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
889513002781	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
889513002782	putative tRNA-binding site [nucleotide binding]; other site
889513002783	B3/4 domain; Region: B3_4; pfam03483
889513002784	tRNA synthetase B5 domain; Region: B5; smart00874
889513002785	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
889513002786	dimer interface [polypeptide binding]; other site
889513002787	motif 1; other site
889513002788	motif 3; other site
889513002789	motif 2; other site
889513002790	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
889513002791	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
889513002792	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
889513002793	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
889513002794	feedback inhibition sensing region; other site
889513002795	homohexameric interface [polypeptide binding]; other site
889513002796	nucleotide binding site [chemical binding]; other site
889513002797	N-acetyl-L-glutamate binding site [chemical binding]; other site
889513002798	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
889513002799	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889513002800	inhibitor-cofactor binding pocket; inhibition site
889513002801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513002802	catalytic residue [active]
889513002803	ornithine carbamoyltransferase; Provisional; Region: PRK00779
889513002804	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
889513002805	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
889513002806	arginine repressor; Provisional; Region: PRK03341
889513002807	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
889513002808	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
889513002809	argininosuccinate synthase; Provisional; Region: PRK13820
889513002810	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
889513002811	ANP binding site [chemical binding]; other site
889513002812	Substrate Binding Site II [chemical binding]; other site
889513002813	Substrate Binding Site I [chemical binding]; other site
889513002814	argininosuccinate lyase; Provisional; Region: PRK00855
889513002815	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
889513002816	active sites [active]
889513002817	tetramer interface [polypeptide binding]; other site
889513002818	Uncharacterized conserved protein [Function unknown]; Region: COG2835
889513002819	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
889513002820	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
889513002821	active site
889513002822	HIGH motif; other site
889513002823	dimer interface [polypeptide binding]; other site
889513002824	KMSKS motif; other site
889513002825	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889513002826	RNA binding surface [nucleotide binding]; other site
889513002827	transcription termination factor Rho; Provisional; Region: PRK12678
889513002828	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
889513002829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513002830	active site
889513002831	motif I; other site
889513002832	motif II; other site
889513002833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513002834	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
889513002835	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889513002836	RNA binding surface [nucleotide binding]; other site
889513002837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002838	S-adenosylmethionine binding site [chemical binding]; other site
889513002839	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
889513002840	ATP-NAD kinase; Region: NAD_kinase; pfam01513
889513002841	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
889513002842	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
889513002843	Walker A/P-loop; other site
889513002844	ATP binding site [chemical binding]; other site
889513002845	Q-loop/lid; other site
889513002846	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
889513002847	ABC transporter signature motif; other site
889513002848	Walker B; other site
889513002849	D-loop; other site
889513002850	H-loop/switch region; other site
889513002851	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
889513002852	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
889513002853	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
889513002854	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
889513002855	dimer interface [polypeptide binding]; other site
889513002856	ADP-ribose binding site [chemical binding]; other site
889513002857	active site
889513002858	nudix motif; other site
889513002859	metal binding site [ion binding]; metal-binding site
889513002860	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
889513002861	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
889513002862	active site
889513002863	Int/Topo IB signature motif; other site
889513002864	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889513002865	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889513002866	P-loop; other site
889513002867	Magnesium ion binding site [ion binding]; other site
889513002868	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
889513002869	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
889513002870	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
889513002871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513002872	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889513002873	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
889513002874	inhibitor-cofactor binding pocket; inhibition site
889513002875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513002876	catalytic residue [active]
889513002877	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
889513002878	AAA domain; Region: AAA_26; pfam13500
889513002879	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
889513002880	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
889513002881	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889513002882	RNA binding surface [nucleotide binding]; other site
889513002883	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
889513002884	active site
889513002885	cytidylate kinase; Provisional; Region: cmk; PRK00023
889513002886	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
889513002887	CMP-binding site; other site
889513002888	The sites determining sugar specificity; other site
889513002889	GTP-binding protein Der; Reviewed; Region: PRK03003
889513002890	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
889513002891	G1 box; other site
889513002892	GTP/Mg2+ binding site [chemical binding]; other site
889513002893	Switch I region; other site
889513002894	G2 box; other site
889513002895	Switch II region; other site
889513002896	G3 box; other site
889513002897	G4 box; other site
889513002898	G5 box; other site
889513002899	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
889513002900	G1 box; other site
889513002901	GTP/Mg2+ binding site [chemical binding]; other site
889513002902	Switch I region; other site
889513002903	G2 box; other site
889513002904	G3 box; other site
889513002905	Switch II region; other site
889513002906	G4 box; other site
889513002907	G5 box; other site
889513002908	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
889513002909	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
889513002910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002911	S-adenosylmethionine binding site [chemical binding]; other site
889513002912	Predicted esterase [General function prediction only]; Region: COG0627
889513002913	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
889513002914	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
889513002915	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513002916	intersubunit interface [polypeptide binding]; other site
889513002917	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513002918	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513002919	dimer interface [polypeptide binding]; other site
889513002920	ABC-ATPase subunit  interface; other site
889513002921	putative PBP binding regions; other site
889513002922	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513002923	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513002924	ABC-ATPase subunit  interface; other site
889513002925	dimer interface [polypeptide binding]; other site
889513002926	putative PBP binding regions; other site
889513002927	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513002928	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513002929	Walker A/P-loop; other site
889513002930	ATP binding site [chemical binding]; other site
889513002931	Q-loop/lid; other site
889513002932	ABC transporter signature motif; other site
889513002933	Walker B; other site
889513002934	D-loop; other site
889513002935	H-loop/switch region; other site
889513002936	IucA / IucC family; Region: IucA_IucC; pfam04183
889513002937	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
889513002938	IucA / IucC family; Region: IucA_IucC; pfam04183
889513002939	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
889513002940	H+ Antiporter protein; Region: 2A0121; TIGR00900
889513002941	hypothetical protein; Provisional; Region: PRK01842
889513002942	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889513002943	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889513002944	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
889513002945	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
889513002946	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
889513002947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513002948	nucleotide binding region [chemical binding]; other site
889513002949	ATP-binding site [chemical binding]; other site
889513002950	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
889513002951	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
889513002952	phosphopeptide binding site; other site
889513002953	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
889513002954	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
889513002955	DNA binding residues [nucleotide binding]
889513002956	Bifunctional nuclease; Region: DNase-RNase; pfam02577
889513002957	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
889513002958	DNA binding residues [nucleotide binding]
889513002959	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
889513002960	putative dimer interface [polypeptide binding]; other site
889513002961	Domain of unknown function DUF21; Region: DUF21; pfam01595
889513002962	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
889513002963	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
889513002964	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
889513002965	Domain of unknown function DUF21; Region: DUF21; pfam01595
889513002966	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
889513002967	Transporter associated domain; Region: CorC_HlyC; smart01091
889513002968	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
889513002969	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
889513002970	ATP binding site [chemical binding]; other site
889513002971	putative Mg++ binding site [ion binding]; other site
889513002972	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513002973	nucleotide binding region [chemical binding]; other site
889513002974	ATP-binding site [chemical binding]; other site
889513002975	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
889513002976	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
889513002977	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
889513002978	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889513002979	CoenzymeA binding site [chemical binding]; other site
889513002980	subunit interaction site [polypeptide binding]; other site
889513002981	PHB binding site; other site
889513002982	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
889513002983	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
889513002984	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
889513002985	oligomer interface [polypeptide binding]; other site
889513002986	metal binding site [ion binding]; metal-binding site
889513002987	metal binding site [ion binding]; metal-binding site
889513002988	putative Cl binding site [ion binding]; other site
889513002989	basic sphincter; other site
889513002990	hydrophobic gate; other site
889513002991	periplasmic entrance; other site
889513002992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513002993	S-adenosylmethionine binding site [chemical binding]; other site
889513002994	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
889513002995	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889513002996	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889513002997	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
889513002998	metabolite-proton symporter; Region: 2A0106; TIGR00883
889513002999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513003000	putative substrate translocation pore; other site
889513003001	YceI-like domain; Region: YceI; pfam04264
889513003002	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
889513003003	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
889513003004	Ligand binding site; other site
889513003005	Putative Catalytic site; other site
889513003006	DXD motif; other site
889513003007	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
889513003008	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
889513003009	putative active site [active]
889513003010	catalytic triad [active]
889513003011	putative dimer interface [polypeptide binding]; other site
889513003012	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
889513003013	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
889513003014	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
889513003015	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
889513003016	precorrin-3B synthase; Region: CobG; TIGR02435
889513003017	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
889513003018	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
889513003019	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
889513003020	Precorrin-8X methylmutase; Region: CbiC; pfam02570
889513003021	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
889513003022	active site
889513003023	SAM binding site [chemical binding]; other site
889513003024	homodimer interface [polypeptide binding]; other site
889513003025	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
889513003026	active site
889513003027	SAM binding site [chemical binding]; other site
889513003028	homodimer interface [polypeptide binding]; other site
889513003029	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
889513003030	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
889513003031	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
889513003032	active site
889513003033	SAM binding site [chemical binding]; other site
889513003034	homodimer interface [polypeptide binding]; other site
889513003035	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
889513003036	active site
889513003037	putative homodimer interface [polypeptide binding]; other site
889513003038	SAM binding site [chemical binding]; other site
889513003039	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
889513003040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513003041	S-adenosylmethionine binding site [chemical binding]; other site
889513003042	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
889513003043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513003044	NAD(P) binding site [chemical binding]; other site
889513003045	active site
889513003046	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
889513003047	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
889513003048	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
889513003049	active site
889513003050	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
889513003051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513003052	ATP binding site [chemical binding]; other site
889513003053	putative Mg++ binding site [ion binding]; other site
889513003054	helicase superfamily c-terminal domain; Region: HELICc; smart00490
889513003055	nucleotide binding region [chemical binding]; other site
889513003056	ATP-binding site [chemical binding]; other site
889513003057	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
889513003058	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
889513003059	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
889513003060	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
889513003061	Predicted transcriptional regulator [Transcription]; Region: COG2378
889513003062	WYL domain; Region: WYL; pfam13280
889513003063	Predicted transcriptional regulator [Transcription]; Region: COG2378
889513003064	WYL domain; Region: WYL; pfam13280
889513003065	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
889513003066	Pup-like protein; Region: Pup; pfam05639
889513003067	Pup-ligase protein; Region: Pup_ligase; cl15463
889513003068	proteasome ATPase; Region: pup_AAA; TIGR03689
889513003069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513003070	Walker A motif; other site
889513003071	ATP binding site [chemical binding]; other site
889513003072	Walker B motif; other site
889513003073	arginine finger; other site
889513003074	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
889513003075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
889513003076	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
889513003077	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
889513003078	active site
889513003079	metal binding site [ion binding]; metal-binding site
889513003080	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
889513003081	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
889513003082	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
889513003083	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
889513003084	Potassium binding sites [ion binding]; other site
889513003085	Cesium cation binding sites [ion binding]; other site
889513003086	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
889513003087	Aspartase; Region: Aspartase; cd01357
889513003088	active sites [active]
889513003089	tetramer interface [polypeptide binding]; other site
889513003090	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
889513003091	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
889513003092	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
889513003093	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
889513003094	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
889513003095	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
889513003096	homodimer interface [polypeptide binding]; other site
889513003097	putative metal binding site [ion binding]; other site
889513003098	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
889513003099	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513003100	motif II; other site
889513003101	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
889513003102	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
889513003103	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
889513003104	substrate binding pocket [chemical binding]; other site
889513003105	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
889513003106	B12 binding site [chemical binding]; other site
889513003107	cobalt ligand [ion binding]; other site
889513003108	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
889513003109	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
889513003110	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513003111	active site
889513003112	HIGH motif; other site
889513003113	nucleotide binding site [chemical binding]; other site
889513003114	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513003115	active site
889513003116	KMSKS motif; other site
889513003117	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
889513003118	tRNA binding surface [nucleotide binding]; other site
889513003119	anticodon binding site; other site
889513003120	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
889513003121	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
889513003122	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
889513003123	active site
889513003124	catalytic tetrad [active]
889513003125	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
889513003126	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
889513003127	quinone interaction residues [chemical binding]; other site
889513003128	active site
889513003129	catalytic residues [active]
889513003130	FMN binding site [chemical binding]; other site
889513003131	substrate binding site [chemical binding]; other site
889513003132	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
889513003133	substrate binding site [chemical binding]; other site
889513003134	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
889513003135	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
889513003136	dimerization domain swap beta strand [polypeptide binding]; other site
889513003137	regulatory protein interface [polypeptide binding]; other site
889513003138	active site
889513003139	regulatory phosphorylation site [posttranslational modification]; other site
889513003140	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
889513003141	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
889513003142	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
889513003143	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
889513003144	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513003145	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
889513003146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513003147	NAD(P) binding site [chemical binding]; other site
889513003148	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
889513003149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513003150	NAD(P) binding site [chemical binding]; other site
889513003151	active site
889513003152	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
889513003153	GTP/Mg2+ binding site [chemical binding]; other site
889513003154	G4 box; other site
889513003155	membrane ATPase/protein kinase; Provisional; Region: PRK09435
889513003156	G5 box; other site
889513003157	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
889513003158	Walker A; other site
889513003159	G1 box; other site
889513003160	Switch I region; other site
889513003161	G2 box; other site
889513003162	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
889513003163	G4 box; other site
889513003164	G5 box; other site
889513003165	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
889513003166	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
889513003167	active site
889513003168	substrate binding site [chemical binding]; other site
889513003169	coenzyme B12 binding site [chemical binding]; other site
889513003170	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
889513003171	B12 binding site [chemical binding]; other site
889513003172	cobalt ligand [ion binding]; other site
889513003173	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
889513003174	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
889513003175	heterodimer interface [polypeptide binding]; other site
889513003176	substrate interaction site [chemical binding]; other site
889513003177	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
889513003178	Uncharacterized conserved protein [Function unknown]; Region: COG0398
889513003179	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
889513003180	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
889513003181	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
889513003182	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
889513003183	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
889513003184	ferrochelatase; Reviewed; Region: hemH; PRK00035
889513003185	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
889513003186	C-terminal domain interface [polypeptide binding]; other site
889513003187	active site
889513003188	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
889513003189	active site
889513003190	N-terminal domain interface [polypeptide binding]; other site
889513003191	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
889513003192	NlpC/P60 family; Region: NLPC_P60; pfam00877
889513003193	pyruvate carboxylase subunit A; Validated; Region: PRK07178
889513003194	aconitate hydratase; Validated; Region: PRK09277
889513003195	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
889513003196	substrate binding site [chemical binding]; other site
889513003197	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
889513003198	ligand binding site [chemical binding]; other site
889513003199	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
889513003200	substrate binding site [chemical binding]; other site
889513003201	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
889513003202	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513003203	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
889513003204	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128
889513003205	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
889513003206	catalytic triad [active]
889513003207	conserved cys residue [active]
889513003208	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
889513003209	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
889513003210	AAA ATPase domain; Region: AAA_16; pfam13191
889513003211	AAA domain; Region: AAA_22; pfam13401
889513003212	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
889513003213	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513003214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513003215	Walker A/P-loop; other site
889513003216	ATP binding site [chemical binding]; other site
889513003217	Q-loop/lid; other site
889513003218	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513003219	ABC transporter signature motif; other site
889513003220	Walker B; other site
889513003221	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513003222	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
889513003223	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
889513003224	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
889513003225	trimerization site [polypeptide binding]; other site
889513003226	active site
889513003227	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
889513003228	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
889513003229	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889513003230	catalytic residue [active]
889513003231	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
889513003232	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
889513003233	Walker A/P-loop; other site
889513003234	ATP binding site [chemical binding]; other site
889513003235	Q-loop/lid; other site
889513003236	ABC transporter signature motif; other site
889513003237	Walker B; other site
889513003238	D-loop; other site
889513003239	H-loop/switch region; other site
889513003240	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
889513003241	FeS assembly protein SufD; Region: sufD; TIGR01981
889513003242	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
889513003243	FeS assembly protein SufB; Region: sufB; TIGR01980
889513003244	Predicted transcriptional regulator [Transcription]; Region: COG2345
889513003245	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889513003246	putative DNA binding site [nucleotide binding]; other site
889513003247	putative Zn2+ binding site [ion binding]; other site
889513003248	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
889513003249	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
889513003250	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
889513003251	Walker A/P-loop; other site
889513003252	ATP binding site [chemical binding]; other site
889513003253	Q-loop/lid; other site
889513003254	ABC transporter signature motif; other site
889513003255	Walker B; other site
889513003256	D-loop; other site
889513003257	H-loop/switch region; other site
889513003258	ABC-2 type transporter; Region: ABC2_membrane; cl17235
889513003259	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
889513003260	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
889513003261	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
889513003262	UbiA prenyltransferase family; Region: UbiA; pfam01040
889513003263	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
889513003264	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
889513003265	TPP-binding site [chemical binding]; other site
889513003266	dimer interface [polypeptide binding]; other site
889513003267	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
889513003268	PYR/PP interface [polypeptide binding]; other site
889513003269	dimer interface [polypeptide binding]; other site
889513003270	TPP binding site [chemical binding]; other site
889513003271	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
889513003272	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
889513003273	putative active site [active]
889513003274	transaldolase; Provisional; Region: PRK03903
889513003275	catalytic residue [active]
889513003276	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
889513003277	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
889513003278	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
889513003279	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
889513003280	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
889513003281	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
889513003282	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
889513003283	putative active site [active]
889513003284	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
889513003285	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
889513003286	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
889513003287	triosephosphate isomerase; Provisional; Region: PRK14567
889513003288	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
889513003289	substrate binding site [chemical binding]; other site
889513003290	dimer interface [polypeptide binding]; other site
889513003291	catalytic triad [active]
889513003292	Phosphoglycerate kinase; Region: PGK; pfam00162
889513003293	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
889513003294	substrate binding site [chemical binding]; other site
889513003295	hinge regions; other site
889513003296	ADP binding site [chemical binding]; other site
889513003297	catalytic site [active]
889513003298	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
889513003299	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
889513003300	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
889513003301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
889513003302	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
889513003303	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
889513003304	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
889513003305	phosphate binding site [ion binding]; other site
889513003306	putative substrate binding pocket [chemical binding]; other site
889513003307	dimer interface [polypeptide binding]; other site
889513003308	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
889513003309	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
889513003310	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
889513003311	GIY-YIG motif/motif A; other site
889513003312	active site
889513003313	catalytic site [active]
889513003314	putative DNA binding site [nucleotide binding]; other site
889513003315	metal binding site [ion binding]; metal-binding site
889513003316	UvrB/uvrC motif; Region: UVR; pfam02151
889513003317	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
889513003318	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
889513003319	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
889513003320	homopentamer interface [polypeptide binding]; other site
889513003321	active site
889513003322	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
889513003323	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
889513003324	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
889513003325	dimerization interface [polypeptide binding]; other site
889513003326	active site
889513003327	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
889513003328	Lumazine binding domain; Region: Lum_binding; pfam00677
889513003329	Lumazine binding domain; Region: Lum_binding; pfam00677
889513003330	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
889513003331	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
889513003332	catalytic motif [active]
889513003333	Zn binding site [ion binding]; other site
889513003334	RibD C-terminal domain; Region: RibD_C; pfam01872
889513003335	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
889513003336	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
889513003337	substrate binding site [chemical binding]; other site
889513003338	hexamer interface [polypeptide binding]; other site
889513003339	metal binding site [ion binding]; metal-binding site
889513003340	16S rRNA methyltransferase B; Provisional; Region: PRK14902
889513003341	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
889513003342	putative RNA binding site [nucleotide binding]; other site
889513003343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513003344	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
889513003345	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
889513003346	putative active site [active]
889513003347	substrate binding site [chemical binding]; other site
889513003348	putative cosubstrate binding site; other site
889513003349	catalytic site [active]
889513003350	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
889513003351	substrate binding site [chemical binding]; other site
889513003352	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
889513003353	active site
889513003354	catalytic residues [active]
889513003355	metal binding site [ion binding]; metal-binding site
889513003356	primosome assembly protein PriA; Provisional; Region: PRK14873
889513003357	S-adenosylmethionine synthetase; Validated; Region: PRK05250
889513003358	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
889513003359	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
889513003360	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
889513003361	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
889513003362	Flavoprotein; Region: Flavoprotein; pfam02441
889513003363	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
889513003364	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
889513003365	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
889513003366	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
889513003367	catalytic site [active]
889513003368	G-X2-G-X-G-K; other site
889513003369	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
889513003370	active site
889513003371	dimer interface [polypeptide binding]; other site
889513003372	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
889513003373	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889513003374	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889513003375	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
889513003376	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889513003377	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889513003378	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
889513003379	IMP binding site; other site
889513003380	dimer interface [polypeptide binding]; other site
889513003381	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
889513003382	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
889513003383	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
889513003384	catalytic site [active]
889513003385	subunit interface [polypeptide binding]; other site
889513003386	dihydroorotase; Validated; Region: pyrC; PRK09357
889513003387	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
889513003388	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
889513003389	active site
889513003390	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
889513003391	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
889513003392	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
889513003393	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
889513003394	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513003395	active site
889513003396	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
889513003397	putative hydrophobic ligand binding site [chemical binding]; other site
889513003398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513003399	TIGR01777 family protein; Region: yfcH
889513003400	NAD(P) binding site [chemical binding]; other site
889513003401	active site
889513003402	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
889513003403	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
889513003404	putative RNA binding site [nucleotide binding]; other site
889513003405	elongation factor P; Validated; Region: PRK00529
889513003406	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
889513003407	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
889513003408	RNA binding site [nucleotide binding]; other site
889513003409	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
889513003410	RNA binding site [nucleotide binding]; other site
889513003411	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
889513003412	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
889513003413	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
889513003414	active site
889513003415	Dehydroquinase class II; Region: DHquinase_II; pfam01220
889513003416	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
889513003417	trimer interface [polypeptide binding]; other site
889513003418	active site
889513003419	dimer interface [polypeptide binding]; other site
889513003420	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
889513003421	active site
889513003422	dimer interface [polypeptide binding]; other site
889513003423	metal binding site [ion binding]; metal-binding site
889513003424	shikimate kinase; Reviewed; Region: aroK; PRK00131
889513003425	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
889513003426	ADP binding site [chemical binding]; other site
889513003427	magnesium binding site [ion binding]; other site
889513003428	putative shikimate binding site; other site
889513003429	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
889513003430	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
889513003431	Tetramer interface [polypeptide binding]; other site
889513003432	active site
889513003433	FMN-binding site [chemical binding]; other site
889513003434	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
889513003435	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
889513003436	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
889513003437	shikimate binding site; other site
889513003438	NAD(P) binding site [chemical binding]; other site
889513003439	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
889513003440	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
889513003441	dimerization interface [polypeptide binding]; other site
889513003442	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
889513003443	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
889513003444	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
889513003445	motif 1; other site
889513003446	active site
889513003447	motif 2; other site
889513003448	motif 3; other site
889513003449	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
889513003450	DHHA1 domain; Region: DHHA1; pfam02272
889513003451	recombination factor protein RarA; Reviewed; Region: PRK13342
889513003452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513003453	Walker A motif; other site
889513003454	ATP binding site [chemical binding]; other site
889513003455	Walker B motif; other site
889513003456	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
889513003457	Phosphotransferase enzyme family; Region: APH; pfam01636
889513003458	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
889513003459	substrate binding site [chemical binding]; other site
889513003460	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
889513003461	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
889513003462	dimer interface [polypeptide binding]; other site
889513003463	anticodon binding site; other site
889513003464	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
889513003465	homodimer interface [polypeptide binding]; other site
889513003466	motif 1; other site
889513003467	active site
889513003468	motif 2; other site
889513003469	GAD domain; Region: GAD; pfam02938
889513003470	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889513003471	active site
889513003472	motif 3; other site
889513003473	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
889513003474	DEAD-like helicases superfamily; Region: DEXDc; smart00487
889513003475	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513003476	ATP binding site [chemical binding]; other site
889513003477	putative Mg++ binding site [ion binding]; other site
889513003478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513003479	nucleotide binding region [chemical binding]; other site
889513003480	ATP-binding site [chemical binding]; other site
889513003481	Predicted membrane protein [Function unknown]; Region: COG1511
889513003482	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
889513003483	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
889513003484	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
889513003485	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
889513003486	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
889513003487	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513003488	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513003489	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889513003490	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
889513003491	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
889513003492	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
889513003493	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
889513003494	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
889513003495	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
889513003496	putative active site [active]
889513003497	putative catalytic site [active]
889513003498	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
889513003499	CoA-transferase family III; Region: CoA_transf_3; pfam02515
889513003500	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
889513003501	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
889513003502	dimer interface [polypeptide binding]; other site
889513003503	motif 1; other site
889513003504	active site
889513003505	motif 2; other site
889513003506	motif 3; other site
889513003507	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
889513003508	anticodon binding site; other site
889513003509	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
889513003510	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
889513003511	dimer interface [polypeptide binding]; other site
889513003512	catalytic triad [active]
889513003513	peroxidatic and resolving cysteines [active]
889513003514	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
889513003515	active site
889513003516	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
889513003517	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889513003518	Zn2+ binding site [ion binding]; other site
889513003519	Mg2+ binding site [ion binding]; other site
889513003520	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
889513003521	synthetase active site [active]
889513003522	NTP binding site [chemical binding]; other site
889513003523	metal binding site [ion binding]; metal-binding site
889513003524	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
889513003525	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
889513003526	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513003527	active site
889513003528	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
889513003529	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
889513003530	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
889513003531	Protein export membrane protein; Region: SecD_SecF; pfam02355
889513003532	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
889513003533	Protein export membrane protein; Region: SecD_SecF; cl14618
889513003534	Preprotein translocase subunit; Region: YajC; pfam02699
889513003535	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
889513003536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513003537	Walker A motif; other site
889513003538	ATP binding site [chemical binding]; other site
889513003539	Walker B motif; other site
889513003540	arginine finger; other site
889513003541	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
889513003542	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
889513003543	RuvA N terminal domain; Region: RuvA_N; pfam01330
889513003544	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
889513003545	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
889513003546	active site
889513003547	putative DNA-binding cleft [nucleotide binding]; other site
889513003548	dimer interface [polypeptide binding]; other site
889513003549	hypothetical protein; Validated; Region: PRK00110
889513003550	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
889513003551	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
889513003552	active site
889513003553	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
889513003554	catalytic triad [active]
889513003555	dimer interface [polypeptide binding]; other site
889513003556	Protein of unknown function (DUF998); Region: DUF998; pfam06197
889513003557	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
889513003558	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
889513003559	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
889513003560	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889513003561	catalytic residue [active]
889513003562	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889513003563	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
889513003564	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
889513003565	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
889513003566	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
889513003567	putative acyl-acceptor binding pocket; other site
889513003568	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
889513003569	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
889513003570	nucleotide binding site/active site [active]
889513003571	HIT family signature motif; other site
889513003572	catalytic residue [active]
889513003573	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
889513003574	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
889513003575	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
889513003576	active site
889513003577	dimer interface [polypeptide binding]; other site
889513003578	motif 1; other site
889513003579	motif 2; other site
889513003580	motif 3; other site
889513003581	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
889513003582	anticodon binding site; other site
889513003583	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
889513003584	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
889513003585	Protein of unknown function (DUF461); Region: DUF461; pfam04314
889513003586	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
889513003587	hypothetical protein; Provisional; Region: PRK14059
889513003588	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
889513003589	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
889513003590	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
889513003591	SelR domain; Region: SelR; pfam01641
889513003592	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
889513003593	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
889513003594	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
889513003595	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
889513003596	catalytic site [active]
889513003597	putative active site [active]
889513003598	putative substrate binding site [chemical binding]; other site
889513003599	HRDC domain; Region: HRDC; pfam00570
889513003600	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
889513003601	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
889513003602	TPP-binding site; other site
889513003603	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
889513003604	PYR/PP interface [polypeptide binding]; other site
889513003605	dimer interface [polypeptide binding]; other site
889513003606	TPP binding site [chemical binding]; other site
889513003607	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
889513003608	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
889513003609	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
889513003610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513003611	S-adenosylmethionine binding site [chemical binding]; other site
889513003612	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
889513003613	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
889513003614	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
889513003615	trimer interface [polypeptide binding]; other site
889513003616	active site
889513003617	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
889513003618	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
889513003619	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
889513003620	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
889513003621	nucleotide binding site [chemical binding]; other site
889513003622	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
889513003623	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
889513003624	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513003625	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
889513003626	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513003627	DNA binding residues [nucleotide binding]
889513003628	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
889513003629	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513003630	ATP binding site [chemical binding]; other site
889513003631	putative Mg++ binding site [ion binding]; other site
889513003632	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
889513003633	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
889513003634	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
889513003635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513003636	S-adenosylmethionine binding site [chemical binding]; other site
889513003637	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
889513003638	putative active site [active]
889513003639	dimerization interface [polypeptide binding]; other site
889513003640	putative tRNAtyr binding site [nucleotide binding]; other site
889513003641	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
889513003642	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
889513003643	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513003644	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
889513003645	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513003646	DNA binding residues [nucleotide binding]
889513003647	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
889513003648	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
889513003649	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
889513003650	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
889513003651	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
889513003652	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
889513003653	NAD binding site [chemical binding]; other site
889513003654	homodimer interface [polypeptide binding]; other site
889513003655	active site
889513003656	substrate binding site [chemical binding]; other site
889513003657	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
889513003658	PAC2 family; Region: PAC2; pfam09754
889513003659	DEAD-like helicases superfamily; Region: DEXDc; smart00487
889513003660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513003661	ATP binding site [chemical binding]; other site
889513003662	putative Mg++ binding site [ion binding]; other site
889513003663	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513003664	nucleotide binding region [chemical binding]; other site
889513003665	ATP-binding site [chemical binding]; other site
889513003666	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
889513003667	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
889513003668	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
889513003669	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
889513003670	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
889513003671	dimer interface [polypeptide binding]; other site
889513003672	decamer (pentamer of dimers) interface [polypeptide binding]; other site
889513003673	catalytic triad [active]
889513003674	peroxidatic and resolving cysteines [active]
889513003675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889513003676	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
889513003677	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
889513003678	dimerization interface [polypeptide binding]; other site
889513003679	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
889513003680	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
889513003681	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513003682	ATP binding site [chemical binding]; other site
889513003683	putative Mg++ binding site [ion binding]; other site
889513003684	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889513003685	nucleotide binding region [chemical binding]; other site
889513003686	ATP-binding site [chemical binding]; other site
889513003687	Helicase associated domain (HA2); Region: HA2; pfam04408
889513003688	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
889513003689	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
889513003690	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
889513003691	ATP cone domain; Region: ATP-cone; pfam03477
889513003692	LexA repressor; Validated; Region: PRK00215
889513003693	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
889513003694	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
889513003695	Catalytic site [active]
889513003696	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
889513003697	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
889513003698	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
889513003699	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
889513003700	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
889513003701	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
889513003702	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
889513003703	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
889513003704	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889513003705	DNA-binding site [nucleotide binding]; DNA binding site
889513003706	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
889513003707	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
889513003708	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
889513003709	putative substrate binding site [chemical binding]; other site
889513003710	putative ATP binding site [chemical binding]; other site
889513003711	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
889513003712	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
889513003713	active site
889513003714	phosphorylation site [posttranslational modification]
889513003715	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
889513003716	active site
889513003717	P-loop; other site
889513003718	phosphorylation site [posttranslational modification]
889513003719	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
889513003720	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
889513003721	dimerization domain swap beta strand [polypeptide binding]; other site
889513003722	regulatory protein interface [polypeptide binding]; other site
889513003723	active site
889513003724	regulatory phosphorylation site [posttranslational modification]; other site
889513003725	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
889513003726	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
889513003727	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
889513003728	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889513003729	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
889513003730	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
889513003731	GTPases [General function prediction only]; Region: HflX; COG2262
889513003732	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
889513003733	HflX GTPase family; Region: HflX; cd01878
889513003734	G1 box; other site
889513003735	GTP/Mg2+ binding site [chemical binding]; other site
889513003736	Switch I region; other site
889513003737	G2 box; other site
889513003738	G3 box; other site
889513003739	Switch II region; other site
889513003740	G4 box; other site
889513003741	G5 box; other site
889513003742	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
889513003743	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
889513003744	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
889513003745	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
889513003746	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
889513003747	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
889513003748	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
889513003749	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
889513003750	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
889513003751	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
889513003752	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513003753	FeS/SAM binding site; other site
889513003754	recombination regulator RecX; Reviewed; Region: recX; PRK00117
889513003755	recombinase A; Provisional; Region: recA; PRK09354
889513003756	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
889513003757	hexamer interface [polypeptide binding]; other site
889513003758	Walker A motif; other site
889513003759	ATP binding site [chemical binding]; other site
889513003760	Walker B motif; other site
889513003761	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
889513003762	BioY family; Region: BioY; pfam02632
889513003763	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
889513003764	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
889513003765	Walker A/P-loop; other site
889513003766	ATP binding site [chemical binding]; other site
889513003767	Q-loop/lid; other site
889513003768	ABC transporter signature motif; other site
889513003769	Walker B; other site
889513003770	D-loop; other site
889513003771	H-loop/switch region; other site
889513003772	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
889513003773	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
889513003774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889513003775	sequence-specific DNA binding site [nucleotide binding]; other site
889513003776	salt bridge; other site
889513003777	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
889513003778	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
889513003779	YCII-related domain; Region: YCII; cl00999
889513003780	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
889513003781	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
889513003782	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
889513003783	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
889513003784	TIGR03085 family protein; Region: TIGR03085
889513003785	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
889513003786	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
889513003787	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
889513003788	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
889513003789	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
889513003790	dimer interface [polypeptide binding]; other site
889513003791	active site
889513003792	catalytic residue [active]
889513003793	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
889513003794	dihydrodipicolinate reductase; Provisional; Region: PRK00048
889513003795	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
889513003796	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
889513003797	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
889513003798	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
889513003799	oligomer interface [polypeptide binding]; other site
889513003800	RNA binding site [nucleotide binding]; other site
889513003801	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
889513003802	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
889513003803	RNase E interface [polypeptide binding]; other site
889513003804	trimer interface [polypeptide binding]; other site
889513003805	active site
889513003806	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
889513003807	putative nucleic acid binding region [nucleotide binding]; other site
889513003808	G-X-X-G motif; other site
889513003809	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
889513003810	RNA binding site [nucleotide binding]; other site
889513003811	domain interface; other site
889513003812	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
889513003813	16S/18S rRNA binding site [nucleotide binding]; other site
889513003814	S13e-L30e interaction site [polypeptide binding]; other site
889513003815	25S rRNA binding site [nucleotide binding]; other site
889513003816	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
889513003817	active site
889513003818	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
889513003819	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
889513003820	active site
889513003821	Riboflavin kinase; Region: Flavokinase; smart00904
889513003822	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
889513003823	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
889513003824	RNA binding site [nucleotide binding]; other site
889513003825	active site
889513003826	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
889513003827	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
889513003828	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
889513003829	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
889513003830	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
889513003831	active site
889513003832	metal binding site [ion binding]; metal-binding site
889513003833	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
889513003834	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
889513003835	DHH family; Region: DHH; pfam01368
889513003836	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
889513003837	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
889513003838	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
889513003839	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
889513003840	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
889513003841	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
889513003842	G1 box; other site
889513003843	putative GEF interaction site [polypeptide binding]; other site
889513003844	GTP/Mg2+ binding site [chemical binding]; other site
889513003845	Switch I region; other site
889513003846	G2 box; other site
889513003847	G3 box; other site
889513003848	Switch II region; other site
889513003849	G4 box; other site
889513003850	G5 box; other site
889513003851	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
889513003852	Translation-initiation factor 2; Region: IF-2; pfam11987
889513003853	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
889513003854	Protein of unknown function (DUF448); Region: DUF448; pfam04296
889513003855	putative RNA binding cleft [nucleotide binding]; other site
889513003856	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
889513003857	NusA N-terminal domain; Region: NusA_N; pfam08529
889513003858	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
889513003859	RNA binding site [nucleotide binding]; other site
889513003860	homodimer interface [polypeptide binding]; other site
889513003861	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
889513003862	G-X-X-G motif; other site
889513003863	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
889513003864	G-X-X-G motif; other site
889513003865	ribosome maturation protein RimP; Reviewed; Region: PRK00092
889513003866	Sm and related proteins; Region: Sm_like; cl00259
889513003867	prolyl-tRNA synthetase; Provisional; Region: PRK09194
889513003868	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
889513003869	dimer interface [polypeptide binding]; other site
889513003870	motif 1; other site
889513003871	active site
889513003872	motif 2; other site
889513003873	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
889513003874	putative deacylase active site [active]
889513003875	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889513003876	active site
889513003877	motif 3; other site
889513003878	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
889513003879	anticodon binding site; other site
889513003880	hypothetical protein; Validated; Region: PRK02101
889513003881	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
889513003882	active site
889513003883	SAM binding site [chemical binding]; other site
889513003884	homodimer interface [polypeptide binding]; other site
889513003885	hypothetical protein; Validated; Region: PRK00029
889513003886	Uncharacterized conserved protein [Function unknown]; Region: COG0397
889513003887	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
889513003888	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
889513003889	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
889513003890	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
889513003891	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
889513003892	DNA binding site [nucleotide binding]
889513003893	active site
889513003894	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
889513003895	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
889513003896	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
889513003897	catalytic triad [active]
889513003898	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
889513003899	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
889513003900	homodimer interface [polypeptide binding]; other site
889513003901	Walker A motif; other site
889513003902	ATP binding site [chemical binding]; other site
889513003903	hydroxycobalamin binding site [chemical binding]; other site
889513003904	Walker B motif; other site
889513003905	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
889513003906	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
889513003907	metal ion-dependent adhesion site (MIDAS); other site
889513003908	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
889513003909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513003910	Walker A motif; other site
889513003911	ATP binding site [chemical binding]; other site
889513003912	Walker B motif; other site
889513003913	arginine finger; other site
889513003914	malate:quinone oxidoreductase; Validated; Region: PRK05257
889513003915	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
889513003916	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
889513003917	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889513003918	mycothione reductase; Reviewed; Region: PRK07846
889513003919	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889513003920	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889513003921	cobyric acid synthase; Provisional; Region: PRK00784
889513003922	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
889513003923	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
889513003924	catalytic triad [active]
889513003925	methionine aminopeptidase; Provisional; Region: PRK12318
889513003926	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
889513003927	active site
889513003928	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
889513003929	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
889513003930	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
889513003931	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
889513003932	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
889513003933	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
889513003934	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
889513003935	active site
889513003936	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
889513003937	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
889513003938	putative substrate binding region [chemical binding]; other site
889513003939	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
889513003940	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
889513003941	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
889513003942	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
889513003943	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
889513003944	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
889513003945	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
889513003946	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
889513003947	ribosome recycling factor; Reviewed; Region: frr; PRK00083
889513003948	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
889513003949	hinge region; other site
889513003950	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
889513003951	putative nucleotide binding site [chemical binding]; other site
889513003952	uridine monophosphate binding site [chemical binding]; other site
889513003953	homohexameric interface [polypeptide binding]; other site
889513003954	elongation factor Ts; Provisional; Region: tsf; PRK09377
889513003955	UBA/TS-N domain; Region: UBA; pfam00627
889513003956	Elongation factor TS; Region: EF_TS; pfam00889
889513003957	Elongation factor TS; Region: EF_TS; pfam00889
889513003958	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
889513003959	rRNA interaction site [nucleotide binding]; other site
889513003960	S8 interaction site; other site
889513003961	putative laminin-1 binding site; other site
889513003962	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889513003963	Peptidase family M23; Region: Peptidase_M23; pfam01551
889513003964	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
889513003965	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889513003966	active site
889513003967	DNA binding site [nucleotide binding]
889513003968	Int/Topo IB signature motif; other site
889513003969	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
889513003970	DNA protecting protein DprA; Region: dprA; TIGR00732
889513003971	hypothetical protein; Reviewed; Region: PRK12497
889513003972	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
889513003973	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
889513003974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513003975	Walker A motif; other site
889513003976	ATP binding site [chemical binding]; other site
889513003977	Walker B motif; other site
889513003978	arginine finger; other site
889513003979	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
889513003980	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
889513003981	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
889513003982	RNA/DNA hybrid binding site [nucleotide binding]; other site
889513003983	active site
889513003984	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
889513003985	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
889513003986	Catalytic site [active]
889513003987	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
889513003988	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
889513003989	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
889513003990	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
889513003991	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
889513003992	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
889513003993	RNA binding site [nucleotide binding]; other site
889513003994	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
889513003995	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
889513003996	active site
889513003997	P-loop; other site
889513003998	phosphorylation site [posttranslational modification]
889513003999	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
889513004000	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
889513004001	active site
889513004002	phosphorylation site [posttranslational modification]
889513004003	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
889513004004	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
889513004005	RimM N-terminal domain; Region: RimM; pfam01782
889513004006	PRC-barrel domain; Region: PRC; pfam05239
889513004007	Cupin domain; Region: Cupin_2; cl17218
889513004008	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
889513004009	signal recognition particle protein; Provisional; Region: PRK10867
889513004010	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
889513004011	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
889513004012	P loop; other site
889513004013	GTP binding site [chemical binding]; other site
889513004014	Signal peptide binding domain; Region: SRP_SPB; pfam02978
889513004015	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
889513004016	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889513004017	metal binding triad; other site
889513004018	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
889513004019	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889513004020	Zn2+ binding site [ion binding]; other site
889513004021	Mg2+ binding site [ion binding]; other site
889513004022	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
889513004023	Nitrogen regulatory protein P-II; Region: P-II; smart00938
889513004024	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
889513004025	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
889513004026	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
889513004027	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
889513004028	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
889513004029	Walker A/P-loop; other site
889513004030	ATP binding site [chemical binding]; other site
889513004031	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
889513004032	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
889513004033	ABC transporter signature motif; other site
889513004034	Walker B; other site
889513004035	D-loop; other site
889513004036	H-loop/switch region; other site
889513004037	Acylphosphatase; Region: Acylphosphatase; cl00551
889513004038	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
889513004039	amino acid carrier protein; Region: agcS; TIGR00835
889513004040	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
889513004041	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
889513004042	DNA binding site [nucleotide binding]
889513004043	catalytic residue [active]
889513004044	H2TH interface [polypeptide binding]; other site
889513004045	putative catalytic residues [active]
889513004046	turnover-facilitating residue; other site
889513004047	intercalation triad [nucleotide binding]; other site
889513004048	8OG recognition residue [nucleotide binding]; other site
889513004049	putative reading head residues; other site
889513004050	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
889513004051	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
889513004052	ribonuclease III; Reviewed; Region: rnc; PRK00102
889513004053	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
889513004054	dimerization interface [polypeptide binding]; other site
889513004055	active site
889513004056	metal binding site [ion binding]; metal-binding site
889513004057	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
889513004058	dsRNA binding site [nucleotide binding]; other site
889513004059	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
889513004060	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
889513004061	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
889513004062	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
889513004063	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
889513004064	hexamer interface [polypeptide binding]; other site
889513004065	ligand binding site [chemical binding]; other site
889513004066	putative active site [active]
889513004067	NAD(P) binding site [chemical binding]; other site
889513004068	glutamate dehydrogenase; Provisional; Region: PRK09414
889513004069	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
889513004070	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
889513004071	NAD(P) binding site [chemical binding]; other site
889513004072	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
889513004073	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
889513004074	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
889513004075	nucleotide binding site/active site [active]
889513004076	HIT family signature motif; other site
889513004077	catalytic residue [active]
889513004078	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
889513004079	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
889513004080	metal binding site [ion binding]; metal-binding site
889513004081	putative dimer interface [polypeptide binding]; other site
889513004082	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
889513004083	homodimer interface [polypeptide binding]; other site
889513004084	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
889513004085	active site pocket [active]
889513004086	Electron transfer DM13; Region: DM13; pfam10517
889513004087	pyruvate kinase; Provisional; Region: PRK06247
889513004088	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
889513004089	domain interfaces; other site
889513004090	active site
889513004091	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
889513004092	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
889513004093	active site
889513004094	ribulose/triose binding site [chemical binding]; other site
889513004095	phosphate binding site [ion binding]; other site
889513004096	substrate (anthranilate) binding pocket [chemical binding]; other site
889513004097	product (indole) binding pocket [chemical binding]; other site
889513004098	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
889513004099	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
889513004100	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
889513004101	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
889513004102	substrate binding site [chemical binding]; other site
889513004103	glutamase interaction surface [polypeptide binding]; other site
889513004104	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
889513004105	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
889513004106	active site
889513004107	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
889513004108	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
889513004109	catalytic residues [active]
889513004110	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
889513004111	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
889513004112	putative active site [active]
889513004113	oxyanion strand; other site
889513004114	catalytic triad [active]
889513004115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513004116	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513004117	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
889513004118	putative active site pocket [active]
889513004119	4-fold oligomerization interface [polypeptide binding]; other site
889513004120	metal binding residues [ion binding]; metal-binding site
889513004121	3-fold/trimer interface [polypeptide binding]; other site
889513004122	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
889513004123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513004124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513004125	homodimer interface [polypeptide binding]; other site
889513004126	catalytic residue [active]
889513004127	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
889513004128	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
889513004129	NAD binding site [chemical binding]; other site
889513004130	dimerization interface [polypeptide binding]; other site
889513004131	product binding site; other site
889513004132	substrate binding site [chemical binding]; other site
889513004133	zinc binding site [ion binding]; other site
889513004134	catalytic residues [active]
889513004135	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
889513004136	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
889513004137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513004138	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
889513004139	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
889513004140	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
889513004141	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
889513004142	active site
889513004143	catalytic site [active]
889513004144	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
889513004145	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
889513004146	active site
889513004147	catalytic site [active]
889513004148	substrate binding site [chemical binding]; other site
889513004149	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
889513004150	Dimer interface [polypeptide binding]; other site
889513004151	BRCT sequence motif; other site
889513004152	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
889513004153	synthetase active site [active]
889513004154	NTP binding site [chemical binding]; other site
889513004155	metal binding site [ion binding]; metal-binding site
889513004156	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889513004157	RNA binding surface [nucleotide binding]; other site
889513004158	Uncharacterized conserved protein [Function unknown]; Region: COG1739
889513004159	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
889513004160	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
889513004161	threonine dehydratase; Validated; Region: PRK08639
889513004162	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
889513004163	tetramer interface [polypeptide binding]; other site
889513004164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513004165	catalytic residue [active]
889513004166	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
889513004167	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
889513004168	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
889513004169	active site
889513004170	PHP Thumb interface [polypeptide binding]; other site
889513004171	metal binding site [ion binding]; metal-binding site
889513004172	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
889513004173	generic binding surface I; other site
889513004174	generic binding surface II; other site
889513004175	Predicted permeases [General function prediction only]; Region: RarD; COG2962
889513004176	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
889513004177	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
889513004178	RNA binding surface [nucleotide binding]; other site
889513004179	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
889513004180	active site
889513004181	lipoprotein signal peptidase; Provisional; Region: PRK14764
889513004182	lipoprotein signal peptidase; Provisional; Region: PRK14787
889513004183	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
889513004184	active site
889513004185	homotetramer interface [polypeptide binding]; other site
889513004186	homodimer interface [polypeptide binding]; other site
889513004187	DNA polymerase IV; Provisional; Region: PRK03348
889513004188	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
889513004189	active site
889513004190	DNA binding site [nucleotide binding]
889513004191	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
889513004192	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
889513004193	HIGH motif; other site
889513004194	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
889513004195	active site
889513004196	KMSKS motif; other site
889513004197	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
889513004198	tRNA binding surface [nucleotide binding]; other site
889513004199	anticodon binding site; other site
889513004200	DivIVA protein; Region: DivIVA; pfam05103
889513004201	DivIVA domain; Region: DivI1A_domain; TIGR03544
889513004202	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
889513004203	YGGT family; Region: YGGT; pfam02325
889513004204	Protein of unknown function (DUF552); Region: DUF552; cl00775
889513004205	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
889513004206	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
889513004207	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
889513004208	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
889513004209	nucleotide binding site [chemical binding]; other site
889513004210	SulA interaction site; other site
889513004211	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
889513004212	Cell division protein FtsQ; Region: FtsQ; pfam03799
889513004213	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
889513004214	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
889513004215	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513004216	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889513004217	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
889513004218	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
889513004219	homodimer interface [polypeptide binding]; other site
889513004220	active site
889513004221	cell division protein FtsW; Region: ftsW; TIGR02614
889513004222	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
889513004223	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513004224	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
889513004225	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
889513004226	Mg++ binding site [ion binding]; other site
889513004227	putative catalytic motif [active]
889513004228	putative substrate binding site [chemical binding]; other site
889513004229	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
889513004230	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
889513004231	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513004232	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889513004233	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
889513004234	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
889513004235	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513004236	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889513004237	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
889513004238	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
889513004239	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
889513004240	MraW methylase family; Region: Methyltransf_5; cl17771
889513004241	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
889513004242	cell division protein MraZ; Reviewed; Region: PRK00326
889513004243	MraZ protein; Region: MraZ; pfam02381
889513004244	MraZ protein; Region: MraZ; pfam02381
889513004245	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
889513004246	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
889513004247	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
889513004248	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
889513004249	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
889513004250	substrate binding pocket [chemical binding]; other site
889513004251	chain length determination region; other site
889513004252	substrate-Mg2+ binding site; other site
889513004253	catalytic residues [active]
889513004254	aspartate-rich region 1; other site
889513004255	active site lid residues [active]
889513004256	aspartate-rich region 2; other site
889513004257	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
889513004258	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
889513004259	Catalytic domain of Protein Kinases; Region: PKc; cd00180
889513004260	active site
889513004261	ATP binding site [chemical binding]; other site
889513004262	substrate binding site [chemical binding]; other site
889513004263	activation loop (A-loop); other site
889513004264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
889513004265	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513004266	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513004267	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513004268	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
889513004269	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
889513004270	Predicted membrane protein [Function unknown]; Region: COG4763
889513004271	Acyltransferase family; Region: Acyl_transf_3; pfam01757
889513004272	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889513004273	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
889513004274	putative acyl-acceptor binding pocket; other site
889513004275	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
889513004276	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
889513004277	nucleotide binding site [chemical binding]; other site
889513004278	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
889513004279	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889513004280	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
889513004281	NlpC/P60 family; Region: NLPC_P60; pfam00877
889513004282	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
889513004283	NlpC/P60 family; Region: NLPC_P60; pfam00877
889513004284	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
889513004285	heme bH binding site [chemical binding]; other site
889513004286	intrachain domain interface; other site
889513004287	heme bL binding site [chemical binding]; other site
889513004288	interchain domain interface [polypeptide binding]; other site
889513004289	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
889513004290	Qo binding site; other site
889513004291	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
889513004292	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
889513004293	iron-sulfur cluster [ion binding]; other site
889513004294	[2Fe-2S] cluster binding site [ion binding]; other site
889513004295	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
889513004296	Cytochrome c; Region: Cytochrom_C; pfam00034
889513004297	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
889513004298	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
889513004299	Subunit I/III interface [polypeptide binding]; other site
889513004300	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
889513004301	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
889513004302	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
889513004303	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
889513004304	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
889513004305	active site
889513004306	dimer interface [polypeptide binding]; other site
889513004307	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
889513004308	Ligand Binding Site [chemical binding]; other site
889513004309	Molecular Tunnel; other site
889513004310	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
889513004311	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
889513004312	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
889513004313	homotrimer interface [polypeptide binding]; other site
889513004314	Walker A motif; other site
889513004315	GTP binding site [chemical binding]; other site
889513004316	Walker B motif; other site
889513004317	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
889513004318	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
889513004319	putative dimer interface [polypeptide binding]; other site
889513004320	active site pocket [active]
889513004321	putative cataytic base [active]
889513004322	cobalamin synthase; Reviewed; Region: cobS; PRK00235
889513004323	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
889513004324	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
889513004325	homodimer interface [polypeptide binding]; other site
889513004326	substrate-cofactor binding pocket; other site
889513004327	catalytic residue [active]
889513004328	multifunctional aminopeptidase A; Provisional; Region: PRK00913
889513004329	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
889513004330	interface (dimer of trimers) [polypeptide binding]; other site
889513004331	Substrate-binding/catalytic site; other site
889513004332	Zn-binding sites [ion binding]; other site
889513004333	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
889513004334	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889513004335	E3 interaction surface; other site
889513004336	lipoyl attachment site [posttranslational modification]; other site
889513004337	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889513004338	E3 interaction surface; other site
889513004339	lipoyl attachment site [posttranslational modification]; other site
889513004340	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889513004341	E3 interaction surface; other site
889513004342	lipoyl attachment site [posttranslational modification]; other site
889513004343	e3 binding domain; Region: E3_binding; pfam02817
889513004344	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
889513004345	glycine dehydrogenase; Provisional; Region: PRK05367
889513004346	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
889513004347	tetramer interface [polypeptide binding]; other site
889513004348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513004349	catalytic residue [active]
889513004350	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
889513004351	tetramer interface [polypeptide binding]; other site
889513004352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513004353	catalytic residue [active]
889513004354	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
889513004355	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
889513004356	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
889513004357	lipoyl attachment site [posttranslational modification]; other site
889513004358	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
889513004359	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889513004360	active site
889513004361	lipoate-protein ligase B; Provisional; Region: PRK14345
889513004362	lipoyl synthase; Provisional; Region: PRK05481
889513004363	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513004364	FeS/SAM binding site; other site
889513004365	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
889513004366	RDD family; Region: RDD; pfam06271
889513004367	glutamine synthetase, type I; Region: GlnA; TIGR00653
889513004368	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
889513004369	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
889513004370	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
889513004371	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
889513004372	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
889513004373	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
889513004374	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
889513004375	DNA methylase; Region: N6_N4_Mtase; pfam01555
889513004376	DNA methylase; Region: N6_N4_Mtase; cl17433
889513004377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513004378	AAA domain; Region: AAA_21; pfam13304
889513004379	Walker A/P-loop; other site
889513004380	ATP binding site [chemical binding]; other site
889513004381	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
889513004382	putative active site [active]
889513004383	putative metal-binding site [ion binding]; other site
889513004384	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
889513004385	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
889513004386	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
889513004387	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
889513004388	HsdM N-terminal domain; Region: HsdM_N; pfam12161
889513004389	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
889513004390	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889513004391	Walker A/P-loop; other site
889513004392	ATP binding site [chemical binding]; other site
889513004393	Q-loop/lid; other site
889513004394	ABC transporter signature motif; other site
889513004395	Walker B; other site
889513004396	D-loop; other site
889513004397	H-loop/switch region; other site
889513004398	Htaa; Region: HtaA; pfam04213
889513004399	Htaa; Region: HtaA; pfam04213
889513004400	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
889513004401	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
889513004402	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
889513004403	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
889513004404	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
889513004405	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
889513004406	active site
889513004407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
889513004408	Predicted permease [General function prediction only]; Region: COG2056
889513004409	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
889513004410	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
889513004411	nudix motif; other site
889513004412	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
889513004413	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
889513004414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513004415	catalytic residue [active]
889513004416	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
889513004417	active site
889513004418	catalytic site [active]
889513004419	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
889513004420	heme binding pocket [chemical binding]; other site
889513004421	heme ligand [chemical binding]; other site
889513004422	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
889513004423	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889513004424	metal binding triad; other site
889513004425	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
889513004426	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889513004427	metal binding triad; other site
889513004428	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
889513004429	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
889513004430	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
889513004431	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
889513004432	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
889513004433	putative active site; other site
889513004434	putative metal binding residues [ion binding]; other site
889513004435	signature motif; other site
889513004436	putative triphosphate binding site [ion binding]; other site
889513004437	CHAD domain; Region: CHAD; pfam05235
889513004438	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
889513004439	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
889513004440	RNB domain; Region: RNB; pfam00773
889513004441	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
889513004442	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
889513004443	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
889513004444	RNA/DNA hybrid binding site [nucleotide binding]; other site
889513004445	active site
889513004446	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889513004447	catalytic core [active]
889513004448	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
889513004449	Putative zinc ribbon domain; Region: DUF164; pfam02591
889513004450	Uncharacterized conserved protein [Function unknown]; Region: COG0327
889513004451	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
889513004452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
889513004453	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
889513004454	hypothetical protein; Provisional; Region: PRK07908
889513004455	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513004456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513004457	homodimer interface [polypeptide binding]; other site
889513004458	catalytic residue [active]
889513004459	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
889513004460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513004461	motif II; other site
889513004462	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
889513004463	Low molecular weight phosphatase family; Region: LMWPc; cd00115
889513004464	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
889513004465	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
889513004466	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
889513004467	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
889513004468	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
889513004469	dimer interface [polypeptide binding]; other site
889513004470	TPP-binding site [chemical binding]; other site
889513004471	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889513004472	Serine hydrolase; Region: Ser_hydrolase; cl17834
889513004473	Phosphopantetheine attachment site; Region: PP-binding; cl09936
889513004474	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
889513004475	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513004476	active site
889513004477	motif I; other site
889513004478	motif II; other site
889513004479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513004480	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
889513004481	Beta-lactamase; Region: Beta-lactamase; pfam00144
889513004482	Predicted membrane protein [Function unknown]; Region: COG2860
889513004483	UPF0126 domain; Region: UPF0126; pfam03458
889513004484	UPF0126 domain; Region: UPF0126; pfam03458
889513004485	DNA primase; Validated; Region: dnaG; PRK05667
889513004486	CHC2 zinc finger; Region: zf-CHC2; pfam01807
889513004487	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
889513004488	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
889513004489	active site
889513004490	metal binding site [ion binding]; metal-binding site
889513004491	interdomain interaction site; other site
889513004492	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
889513004493	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
889513004494	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
889513004495	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
889513004496	glutaminase active site [active]
889513004497	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
889513004498	dimer interface [polypeptide binding]; other site
889513004499	active site
889513004500	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
889513004501	dimer interface [polypeptide binding]; other site
889513004502	active site
889513004503	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
889513004504	active site
889513004505	barstar interaction site; other site
889513004506	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
889513004507	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889513004508	Zn2+ binding site [ion binding]; other site
889513004509	Mg2+ binding site [ion binding]; other site
889513004510	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
889513004511	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
889513004512	putative active site [active]
889513004513	Repair protein; Region: Repair_PSII; pfam04536
889513004514	glycyl-tRNA synthetase; Provisional; Region: PRK04173
889513004515	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889513004516	motif 1; other site
889513004517	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
889513004518	active site
889513004519	motif 2; other site
889513004520	motif 3; other site
889513004521	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
889513004522	anticodon binding site; other site
889513004523	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889513004524	putative DNA binding site [nucleotide binding]; other site
889513004525	putative Zn2+ binding site [ion binding]; other site
889513004526	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
889513004527	metal binding site 2 [ion binding]; metal-binding site
889513004528	putative DNA binding helix; other site
889513004529	metal binding site 1 [ion binding]; metal-binding site
889513004530	dimer interface [polypeptide binding]; other site
889513004531	structural Zn2+ binding site [ion binding]; other site
889513004532	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
889513004533	diiron binding motif [ion binding]; other site
889513004534	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
889513004535	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
889513004536	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
889513004537	catalytic residue [active]
889513004538	putative FPP diphosphate  binding site; other site
889513004539	putative FPP binding hydrophobic cleft; other site
889513004540	dimer interface [polypeptide binding]; other site
889513004541	putative IPP diphosphate binding site; other site
889513004542	Recombination protein O N terminal; Region: RecO_N; pfam11967
889513004543	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
889513004544	Recombination protein O C terminal; Region: RecO_C; pfam02565
889513004545	GTPase Era; Reviewed; Region: era; PRK00089
889513004546	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
889513004547	G1 box; other site
889513004548	GTP/Mg2+ binding site [chemical binding]; other site
889513004549	Switch I region; other site
889513004550	G2 box; other site
889513004551	Switch II region; other site
889513004552	G3 box; other site
889513004553	G4 box; other site
889513004554	G5 box; other site
889513004555	KH domain; Region: KH_2; pfam07650
889513004556	pyridoxamine kinase; Validated; Region: PRK05756
889513004557	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
889513004558	dimer interface [polypeptide binding]; other site
889513004559	pyridoxal binding site [chemical binding]; other site
889513004560	ATP binding site [chemical binding]; other site
889513004561	Domain of unknown function DUF21; Region: DUF21; pfam01595
889513004562	FOG: CBS domain [General function prediction only]; Region: COG0517
889513004563	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
889513004564	Transporter associated domain; Region: CorC_HlyC; smart01091
889513004565	metal-binding heat shock protein; Provisional; Region: PRK00016
889513004566	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
889513004567	PhoH-like protein; Region: PhoH; pfam02562
889513004568	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
889513004569	RNA methyltransferase, RsmE family; Region: TIGR00046
889513004570	chaperone protein DnaJ; Provisional; Region: PRK14278
889513004571	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
889513004572	HSP70 interaction site [polypeptide binding]; other site
889513004573	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
889513004574	Zn binding sites [ion binding]; other site
889513004575	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
889513004576	dimer interface [polypeptide binding]; other site
889513004577	coproporphyrinogen III oxidase; Validated; Region: PRK05628
889513004578	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889513004579	FeS/SAM binding site; other site
889513004580	HemN C-terminal domain; Region: HemN_C; pfam06969
889513004581	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
889513004582	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
889513004583	acyl-activating enzyme (AAE) consensus motif; other site
889513004584	putative AMP binding site [chemical binding]; other site
889513004585	putative active site [active]
889513004586	putative CoA binding site [chemical binding]; other site
889513004587	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
889513004588	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
889513004589	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
889513004590	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
889513004591	active site
889513004592	Zn binding site [ion binding]; other site
889513004593	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
889513004594	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
889513004595	substrate binding pocket [chemical binding]; other site
889513004596	catalytic triad [active]
889513004597	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
889513004598	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
889513004599	active site
889513004600	metal binding site [ion binding]; metal-binding site
889513004601	nudix motif; other site
889513004602	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
889513004603	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
889513004604	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
889513004605	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
889513004606	active site
889513004607	BCCT family transporter; Region: BCCT; pfam02028
889513004608	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
889513004609	Predicted permeases [General function prediction only]; Region: COG0679
889513004610	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
889513004611	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
889513004612	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513004613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513004614	dimer interface [polypeptide binding]; other site
889513004615	conserved gate region; other site
889513004616	putative PBP binding loops; other site
889513004617	ABC-ATPase subunit interface; other site
889513004618	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
889513004619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513004620	dimer interface [polypeptide binding]; other site
889513004621	conserved gate region; other site
889513004622	putative PBP binding loops; other site
889513004623	ABC-ATPase subunit interface; other site
889513004624	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
889513004625	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513004626	Walker A/P-loop; other site
889513004627	ATP binding site [chemical binding]; other site
889513004628	Q-loop/lid; other site
889513004629	ABC transporter signature motif; other site
889513004630	Walker B; other site
889513004631	D-loop; other site
889513004632	H-loop/switch region; other site
889513004633	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513004634	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513004635	Walker A/P-loop; other site
889513004636	ATP binding site [chemical binding]; other site
889513004637	Q-loop/lid; other site
889513004638	ABC transporter signature motif; other site
889513004639	Walker B; other site
889513004640	D-loop; other site
889513004641	H-loop/switch region; other site
889513004642	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513004643	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
889513004644	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
889513004645	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889513004646	catalytic residue [active]
889513004647	Sulphur transport; Region: Sulf_transp; pfam04143
889513004648	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
889513004649	CPxP  motif; other site
889513004650	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513004651	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
889513004652	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
889513004653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
889513004654	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889513004655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513004656	putative substrate translocation pore; other site
889513004657	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513004658	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
889513004659	Walker A/P-loop; other site
889513004660	ATP binding site [chemical binding]; other site
889513004661	Q-loop/lid; other site
889513004662	ABC transporter signature motif; other site
889513004663	Walker B; other site
889513004664	D-loop; other site
889513004665	H-loop/switch region; other site
889513004666	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
889513004667	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513004668	Walker A/P-loop; other site
889513004669	ATP binding site [chemical binding]; other site
889513004670	Q-loop/lid; other site
889513004671	ABC transporter signature motif; other site
889513004672	Walker B; other site
889513004673	D-loop; other site
889513004674	H-loop/switch region; other site
889513004675	GTP-binding protein LepA; Provisional; Region: PRK05433
889513004676	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
889513004677	G1 box; other site
889513004678	putative GEF interaction site [polypeptide binding]; other site
889513004679	GTP/Mg2+ binding site [chemical binding]; other site
889513004680	Switch I region; other site
889513004681	G2 box; other site
889513004682	G3 box; other site
889513004683	Switch II region; other site
889513004684	G4 box; other site
889513004685	G5 box; other site
889513004686	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
889513004687	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
889513004688	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
889513004689	PemK-like protein; Region: PemK; pfam02452
889513004690	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
889513004691	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889513004692	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
889513004693	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
889513004694	hypothetical protein; Validated; Region: PRK05629
889513004695	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
889513004696	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
889513004697	Competence protein; Region: Competence; pfam03772
889513004698	comEA protein; Region: comE; TIGR01259
889513004699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
889513004700	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
889513004701	Oligomerisation domain; Region: Oligomerisation; pfam02410
889513004702	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
889513004703	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
889513004704	active site
889513004705	(T/H)XGH motif; other site
889513004706	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
889513004707	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
889513004708	putative catalytic cysteine [active]
889513004709	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
889513004710	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
889513004711	putative ligand binding site [chemical binding]; other site
889513004712	putative NAD binding site [chemical binding]; other site
889513004713	catalytic site [active]
889513004714	Protein of unknown function (DUF454); Region: DUF454; cl01063
889513004715	Predicted permease [General function prediction only]; Region: COG2985
889513004716	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
889513004717	TrkA-C domain; Region: TrkA_C; pfam02080
889513004718	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
889513004719	gamma-glutamyl kinase; Provisional; Region: PRK05429
889513004720	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
889513004721	nucleotide binding site [chemical binding]; other site
889513004722	homotetrameric interface [polypeptide binding]; other site
889513004723	putative phosphate binding site [ion binding]; other site
889513004724	putative allosteric binding site; other site
889513004725	PUA domain; Region: PUA; pfam01472
889513004726	GTPase CgtA; Reviewed; Region: obgE; PRK12296
889513004727	GTP1/OBG; Region: GTP1_OBG; pfam01018
889513004728	Obg GTPase; Region: Obg; cd01898
889513004729	G1 box; other site
889513004730	GTP/Mg2+ binding site [chemical binding]; other site
889513004731	Switch I region; other site
889513004732	G2 box; other site
889513004733	G3 box; other site
889513004734	Switch II region; other site
889513004735	G4 box; other site
889513004736	G5 box; other site
889513004737	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
889513004738	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
889513004739	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
889513004740	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
889513004741	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
889513004742	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
889513004743	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
889513004744	homodimer interface [polypeptide binding]; other site
889513004745	oligonucleotide binding site [chemical binding]; other site
889513004746	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
889513004747	active site
889513004748	multimer interface [polypeptide binding]; other site
889513004749	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
889513004750	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
889513004751	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
889513004752	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
889513004753	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513004754	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889513004755	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889513004756	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
889513004757	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513004758	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
889513004759	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
889513004760	active site
889513004761	KMSKS motif; other site
889513004762	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
889513004763	tRNA binding surface [nucleotide binding]; other site
889513004764	anticodon binding site; other site
889513004765	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
889513004766	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
889513004767	malate dehydrogenase; Provisional; Region: PRK05442
889513004768	NAD(P) binding site [chemical binding]; other site
889513004769	dimer interface [polypeptide binding]; other site
889513004770	malate binding site [chemical binding]; other site
889513004771	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513004772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513004773	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
889513004774	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
889513004775	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513004776	Walker A motif; other site
889513004777	ATP binding site [chemical binding]; other site
889513004778	Walker B motif; other site
889513004779	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
889513004780	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
889513004781	glutamine binding [chemical binding]; other site
889513004782	Glutamine amidotransferase class-I; Region: GATase; pfam00117
889513004783	catalytic triad [active]
889513004784	hypothetical protein; Validated; Region: PRK09070
889513004785	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
889513004786	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
889513004787	Aminotransferase class IV; Region: Aminotran_4; pfam01063
889513004788	substrate-cofactor binding pocket; other site
889513004789	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
889513004790	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
889513004791	oligomer interface [polypeptide binding]; other site
889513004792	active site residues [active]
889513004793	Clp protease; Region: CLP_protease; pfam00574
889513004794	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
889513004795	oligomer interface [polypeptide binding]; other site
889513004796	active site residues [active]
889513004797	trigger factor; Provisional; Region: tig; PRK01490
889513004798	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889513004799	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
889513004800	Pirin-related protein [General function prediction only]; Region: COG1741
889513004801	Pirin; Region: Pirin; pfam02678
889513004802	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
889513004803	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
889513004804	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
889513004805	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
889513004806	catalytic residues [active]
889513004807	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
889513004808	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
889513004809	Zn binding site [ion binding]; other site
889513004810	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
889513004811	Mechanosensitive ion channel; Region: MS_channel; pfam00924
889513004812	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
889513004813	apolar tunnel; other site
889513004814	heme binding site [chemical binding]; other site
889513004815	dimerization interface [polypeptide binding]; other site
889513004816	Protein of unknown function, DUF606; Region: DUF606; pfam04657
889513004817	Protein of unknown function, DUF606; Region: DUF606; pfam04657
889513004818	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
889513004819	active site
889513004820	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
889513004821	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513004822	Walker A/P-loop; other site
889513004823	ATP binding site [chemical binding]; other site
889513004824	Q-loop/lid; other site
889513004825	ABC transporter signature motif; other site
889513004826	Walker B; other site
889513004827	D-loop; other site
889513004828	H-loop/switch region; other site
889513004829	ABC transporter; Region: ABC_tran_2; pfam12848
889513004830	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889513004831	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
889513004832	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
889513004833	dimer interface [polypeptide binding]; other site
889513004834	ssDNA binding site [nucleotide binding]; other site
889513004835	tetramer (dimer of dimers) interface [polypeptide binding]; other site
889513004836	YcaO-like family; Region: YcaO; pfam02624
889513004837	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
889513004838	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
889513004839	FMN binding site [chemical binding]; other site
889513004840	dimer interface [polypeptide binding]; other site
889513004841	Nitroreductase family; Region: Nitroreductase; pfam00881
889513004842	dimer interface [polypeptide binding]; other site
889513004843	SpaB C-terminal domain; Region: SpaB_C; pfam14028
889513004844	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
889513004845	YcaO-like family; Region: YcaO; pfam02624
889513004846	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
889513004847	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
889513004848	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
889513004849	Walker A/P-loop; other site
889513004850	ATP binding site [chemical binding]; other site
889513004851	Q-loop/lid; other site
889513004852	ABC transporter signature motif; other site
889513004853	Walker B; other site
889513004854	D-loop; other site
889513004855	H-loop/switch region; other site
889513004856	Copper resistance protein D; Region: CopD; pfam05425
889513004857	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
889513004858	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
889513004859	Carbon starvation protein CstA; Region: CstA; pfam02554
889513004860	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
889513004861	Protein of unknown function (DUF466); Region: DUF466; pfam04328
889513004862	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
889513004863	active site
889513004864	catalytic triad [active]
889513004865	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
889513004866	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
889513004867	NADP binding site [chemical binding]; other site
889513004868	dimer interface [polypeptide binding]; other site
889513004869	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
889513004870	classical (c) SDRs; Region: SDR_c; cd05233
889513004871	NAD(P) binding site [chemical binding]; other site
889513004872	active site
889513004873	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
889513004874	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
889513004875	catalytic site [active]
889513004876	putative active site [active]
889513004877	putative substrate binding site [chemical binding]; other site
889513004878	dimer interface [polypeptide binding]; other site
889513004879	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
889513004880	N-acetylneuraminate lyase; Provisional; Region: PRK04147
889513004881	inhibitor site; inhibition site
889513004882	active site
889513004883	dimer interface [polypeptide binding]; other site
889513004884	catalytic residue [active]
889513004885	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
889513004886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
889513004887	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
889513004888	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
889513004889	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
889513004890	Prostaglandin dehydrogenases; Region: PGDH; cd05288
889513004891	NAD(P) binding site [chemical binding]; other site
889513004892	substrate binding site [chemical binding]; other site
889513004893	dimer interface [polypeptide binding]; other site
889513004894	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
889513004895	Isochorismatase family; Region: Isochorismatase; pfam00857
889513004896	catalytic triad [active]
889513004897	metal binding site [ion binding]; metal-binding site
889513004898	conserved cis-peptide bond; other site
889513004899	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
889513004900	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
889513004901	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
889513004902	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
889513004903	catalytic triad [active]
889513004904	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513004905	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513004906	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
889513004907	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
889513004908	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
889513004909	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
889513004910	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
889513004911	phosphate binding site [ion binding]; other site
889513004912	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
889513004913	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
889513004914	active site 2 [active]
889513004915	active site 1 [active]
889513004916	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
889513004917	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
889513004918	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
889513004919	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
889513004920	putative NAD(P) binding site [chemical binding]; other site
889513004921	active site
889513004922	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
889513004923	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
889513004924	active site
889513004925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
889513004926	Histidine kinase; Region: HisKA_3; pfam07730
889513004927	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
889513004928	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889513004929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513004930	active site
889513004931	phosphorylation site [posttranslational modification]
889513004932	intermolecular recognition site; other site
889513004933	dimerization interface [polypeptide binding]; other site
889513004934	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889513004935	DNA binding residues [nucleotide binding]
889513004936	dimerization interface [polypeptide binding]; other site
889513004937	Protein of unknown function (DUF418); Region: DUF418; pfam04235
889513004938	CAAX protease self-immunity; Region: Abi; pfam02517
889513004939	Glucitol operon activator protein (GutM); Region: GutM; cl01890
889513004940	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
889513004941	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
889513004942	active site
889513004943	dimerization interface [polypeptide binding]; other site
889513004944	ribonuclease PH; Reviewed; Region: rph; PRK00173
889513004945	Ribonuclease PH; Region: RNase_PH_bact; cd11362
889513004946	hexamer interface [polypeptide binding]; other site
889513004947	active site
889513004948	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
889513004949	glutamate racemase; Provisional; Region: PRK00865
889513004950	Rhomboid family; Region: Rhomboid; pfam01694
889513004951	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
889513004952	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
889513004953	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
889513004954	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
889513004955	active site
889513004956	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
889513004957	DEAD/DEAH box helicase; Region: DEAD; pfam00270
889513004958	ATP binding site [chemical binding]; other site
889513004959	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889513004960	putative Mg++ binding site [ion binding]; other site
889513004961	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
889513004962	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
889513004963	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
889513004964	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
889513004965	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
889513004966	phosphoserine phosphatase SerB; Region: serB; TIGR00338
889513004967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513004968	motif II; other site
889513004969	Winged helix-turn helix; Region: HTH_29; pfam13551
889513004970	Helix-turn-helix domain; Region: HTH_28; pfam13518
889513004971	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
889513004972	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
889513004973	D-pathway; other site
889513004974	Putative ubiquinol binding site [chemical binding]; other site
889513004975	Low-spin heme (heme b) binding site [chemical binding]; other site
889513004976	Putative water exit pathway; other site
889513004977	Binuclear center (heme o3/CuB) [ion binding]; other site
889513004978	K-pathway; other site
889513004979	Putative proton exit pathway; other site
889513004980	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
889513004981	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
889513004982	dimer interface [polypeptide binding]; other site
889513004983	putative radical transfer pathway; other site
889513004984	diiron center [ion binding]; other site
889513004985	tyrosyl radical; other site
889513004986	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
889513004987	Ferritin-like domain; Region: Ferritin; pfam00210
889513004988	ferroxidase diiron center [ion binding]; other site
889513004989	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
889513004990	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
889513004991	Class I ribonucleotide reductase; Region: RNR_I; cd01679
889513004992	active site
889513004993	dimer interface [polypeptide binding]; other site
889513004994	catalytic residues [active]
889513004995	effector binding site; other site
889513004996	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
889513004997	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
889513004998	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
889513004999	catalytic residues [active]
889513005000	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
889513005001	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
889513005002	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
889513005003	homodimer interface [polypeptide binding]; other site
889513005004	NAD binding pocket [chemical binding]; other site
889513005005	ATP binding pocket [chemical binding]; other site
889513005006	Mg binding site [ion binding]; other site
889513005007	active-site loop [active]
889513005008	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
889513005009	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889513005010	dimerization interface [polypeptide binding]; other site
889513005011	putative DNA binding site [nucleotide binding]; other site
889513005012	putative Zn2+ binding site [ion binding]; other site
889513005013	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
889513005014	Thioredoxin; Region: Thioredoxin_4; cl17273
889513005015	Predicted membrane protein [Function unknown]; Region: COG2259
889513005016	phosphoglucomutase; Validated; Region: PRK07564
889513005017	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
889513005018	active site
889513005019	substrate binding site [chemical binding]; other site
889513005020	metal binding site [ion binding]; metal-binding site
889513005021	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
889513005022	CrcB-like protein; Region: CRCB; pfam02537
889513005023	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
889513005024	FtsX-like permease family; Region: FtsX; pfam02687
889513005025	FtsX-like permease family; Region: FtsX; pfam02687
889513005026	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889513005027	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
889513005028	Walker A/P-loop; other site
889513005029	ATP binding site [chemical binding]; other site
889513005030	Q-loop/lid; other site
889513005031	ABC transporter signature motif; other site
889513005032	Walker B; other site
889513005033	D-loop; other site
889513005034	H-loop/switch region; other site
889513005035	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
889513005036	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
889513005037	hinge; other site
889513005038	active site
889513005039	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
889513005040	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889513005041	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889513005042	DNA binding residues [nucleotide binding]
889513005043	dimerization interface [polypeptide binding]; other site
889513005044	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
889513005045	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
889513005046	dimer interface [polypeptide binding]; other site
889513005047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513005048	catalytic residue [active]
889513005049	serine O-acetyltransferase; Region: cysE; TIGR01172
889513005050	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
889513005051	trimer interface [polypeptide binding]; other site
889513005052	active site
889513005053	substrate binding site [chemical binding]; other site
889513005054	CoA binding site [chemical binding]; other site
889513005055	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513005056	Coenzyme A binding pocket [chemical binding]; other site
889513005057	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
889513005058	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
889513005059	putative active site [active]
889513005060	metal binding site [ion binding]; metal-binding site
889513005061	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
889513005062	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
889513005063	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
889513005064	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889513005065	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
889513005066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513005067	Walker A/P-loop; other site
889513005068	ATP binding site [chemical binding]; other site
889513005069	Q-loop/lid; other site
889513005070	ABC transporter signature motif; other site
889513005071	Walker B; other site
889513005072	D-loop; other site
889513005073	H-loop/switch region; other site
889513005074	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
889513005075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513005076	Walker A/P-loop; other site
889513005077	ATP binding site [chemical binding]; other site
889513005078	Q-loop/lid; other site
889513005079	ABC transporter signature motif; other site
889513005080	Walker B; other site
889513005081	D-loop; other site
889513005082	H-loop/switch region; other site
889513005083	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
889513005084	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
889513005085	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
889513005086	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
889513005087	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
889513005088	FMN binding site [chemical binding]; other site
889513005089	active site
889513005090	catalytic residues [active]
889513005091	substrate binding site [chemical binding]; other site
889513005092	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
889513005093	PhoU domain; Region: PhoU; pfam01895
889513005094	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
889513005095	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
889513005096	Walker A/P-loop; other site
889513005097	ATP binding site [chemical binding]; other site
889513005098	Q-loop/lid; other site
889513005099	ABC transporter signature motif; other site
889513005100	Walker B; other site
889513005101	D-loop; other site
889513005102	H-loop/switch region; other site
889513005103	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
889513005104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513005105	dimer interface [polypeptide binding]; other site
889513005106	conserved gate region; other site
889513005107	putative PBP binding loops; other site
889513005108	ABC-ATPase subunit interface; other site
889513005109	PBP superfamily domain; Region: PBP_like_2; cl17296
889513005110	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
889513005111	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513005112	Coenzyme A binding pocket [chemical binding]; other site
889513005113	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
889513005114	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
889513005115	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
889513005116	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
889513005117	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
889513005118	heme-binding site [chemical binding]; other site
889513005119	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
889513005120	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
889513005121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513005122	catalytic residue [active]
889513005123	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
889513005124	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
889513005125	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
889513005126	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
889513005127	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
889513005128	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
889513005129	dimerization interface [polypeptide binding]; other site
889513005130	putative ATP binding site [chemical binding]; other site
889513005131	amidophosphoribosyltransferase; Provisional; Region: PRK07847
889513005132	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
889513005133	active site
889513005134	tetramer interface [polypeptide binding]; other site
889513005135	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513005136	active site
889513005137	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
889513005138	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
889513005139	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
889513005140	dimer interface [polypeptide binding]; other site
889513005141	putative radical transfer pathway; other site
889513005142	diiron center [ion binding]; other site
889513005143	tyrosyl radical; other site
889513005144	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
889513005145	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
889513005146	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
889513005147	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
889513005148	dimerization interface [polypeptide binding]; other site
889513005149	ATP binding site [chemical binding]; other site
889513005150	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
889513005151	dimerization interface [polypeptide binding]; other site
889513005152	ATP binding site [chemical binding]; other site
889513005153	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
889513005154	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
889513005155	putative active site [active]
889513005156	catalytic triad [active]
889513005157	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
889513005158	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
889513005159	catalytic residues [active]
889513005160	dimer interface [polypeptide binding]; other site
889513005161	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
889513005162	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889513005163	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
889513005164	ATP binding site [chemical binding]; other site
889513005165	active site
889513005166	substrate binding site [chemical binding]; other site
889513005167	adenylosuccinate lyase; Region: purB; TIGR00928
889513005168	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
889513005169	tetramer interface [polypeptide binding]; other site
889513005170	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
889513005171	TrkA-N domain; Region: TrkA_N; pfam02254
889513005172	TrkA-C domain; Region: TrkA_C; pfam02080
889513005173	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
889513005174	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
889513005175	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
889513005176	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
889513005177	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
889513005178	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
889513005179	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
889513005180	nucleotide binding site/active site [active]
889513005181	HIT family signature motif; other site
889513005182	catalytic residue [active]
889513005183	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889513005184	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889513005185	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889513005186	dimerization interface [polypeptide binding]; other site
889513005187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889513005188	dimer interface [polypeptide binding]; other site
889513005189	phosphorylation site [posttranslational modification]
889513005190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513005191	ATP binding site [chemical binding]; other site
889513005192	Mg2+ binding site [ion binding]; other site
889513005193	G-X-G motif; other site
889513005194	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889513005195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513005196	active site
889513005197	phosphorylation site [posttranslational modification]
889513005198	intermolecular recognition site; other site
889513005199	dimerization interface [polypeptide binding]; other site
889513005200	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889513005201	DNA binding site [nucleotide binding]
889513005202	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513005203	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513005204	Predicted esterase [General function prediction only]; Region: COG0627
889513005205	S-formylglutathione hydrolase; Region: PLN02442
889513005206	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
889513005207	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
889513005208	putative active site [active]
889513005209	pyruvate dehydrogenase; Provisional; Region: PRK06546
889513005210	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
889513005211	PYR/PP interface [polypeptide binding]; other site
889513005212	tetramer interface [polypeptide binding]; other site
889513005213	dimer interface [polypeptide binding]; other site
889513005214	TPP binding site [chemical binding]; other site
889513005215	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
889513005216	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
889513005217	TPP-binding site [chemical binding]; other site
889513005218	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
889513005219	Uncharacterized conserved protein [Function unknown]; Region: COG3610
889513005220	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
889513005221	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
889513005222	active site
889513005223	homotetramer interface [polypeptide binding]; other site
889513005224	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
889513005225	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
889513005226	Transcriptional regulators [Transcription]; Region: PurR; COG1609
889513005227	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
889513005228	DNA binding site [nucleotide binding]
889513005229	domain linker motif; other site
889513005230	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
889513005231	putative dimerization interface [polypeptide binding]; other site
889513005232	putative ligand binding site [chemical binding]; other site
889513005233	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
889513005234	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
889513005235	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
889513005236	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
889513005237	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
889513005238	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513005239	active site
889513005240	HIGH motif; other site
889513005241	nucleotide binding site [chemical binding]; other site
889513005242	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
889513005243	KMSKS motif; other site
889513005244	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
889513005245	tRNA binding surface [nucleotide binding]; other site
889513005246	anticodon binding site; other site
889513005247	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
889513005248	homotrimer interaction site [polypeptide binding]; other site
889513005249	zinc binding site [ion binding]; other site
889513005250	CDP-binding sites; other site
889513005251	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
889513005252	substrate binding site; other site
889513005253	dimer interface; other site
889513005254	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
889513005255	DNA repair protein RadA; Provisional; Region: PRK11823
889513005256	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
889513005257	Walker A motif; other site
889513005258	ATP binding site [chemical binding]; other site
889513005259	Walker B motif; other site
889513005260	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
889513005261	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
889513005262	active site clefts [active]
889513005263	zinc binding site [ion binding]; other site
889513005264	dimer interface [polypeptide binding]; other site
889513005265	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
889513005266	endonuclease III; Region: ENDO3c; smart00478
889513005267	minor groove reading motif; other site
889513005268	helix-hairpin-helix signature motif; other site
889513005269	substrate binding pocket [chemical binding]; other site
889513005270	active site
889513005271	Uncharacterized conserved protein [Function unknown]; Region: COG2966
889513005272	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
889513005273	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
889513005274	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
889513005275	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
889513005276	Clp amino terminal domain; Region: Clp_N; pfam02861
889513005277	Clp amino terminal domain; Region: Clp_N; pfam02861
889513005278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513005279	Walker A motif; other site
889513005280	ATP binding site [chemical binding]; other site
889513005281	Walker B motif; other site
889513005282	arginine finger; other site
889513005283	UvrB/uvrC motif; Region: UVR; pfam02151
889513005284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513005285	Walker A motif; other site
889513005286	ATP binding site [chemical binding]; other site
889513005287	Walker B motif; other site
889513005288	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
889513005289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005290	putative substrate translocation pore; other site
889513005291	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
889513005292	active site
889513005293	tetramer interface [polypeptide binding]; other site
889513005294	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
889513005295	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889513005296	CAAX protease self-immunity; Region: Abi; pfam02517
889513005297	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
889513005298	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
889513005299	dimer interface [polypeptide binding]; other site
889513005300	putative anticodon binding site; other site
889513005301	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889513005302	motif 1; other site
889513005303	dimer interface [polypeptide binding]; other site
889513005304	active site
889513005305	motif 2; other site
889513005306	motif 3; other site
889513005307	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
889513005308	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
889513005309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
889513005310	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889513005311	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
889513005312	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
889513005313	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889513005314	NAD(P) binding site [chemical binding]; other site
889513005315	catalytic residues [active]
889513005316	choline dehydrogenase; Validated; Region: PRK02106
889513005317	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
889513005318	pantoate--beta-alanine ligase; Region: panC; TIGR00018
889513005319	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513005320	active site
889513005321	nucleotide binding site [chemical binding]; other site
889513005322	HIGH motif; other site
889513005323	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513005324	KMSKS motif; other site
889513005325	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
889513005326	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
889513005327	catalytic center binding site [active]
889513005328	ATP binding site [chemical binding]; other site
889513005329	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
889513005330	homooctamer interface [polypeptide binding]; other site
889513005331	active site
889513005332	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
889513005333	dihydropteroate synthase; Region: DHPS; TIGR01496
889513005334	substrate binding pocket [chemical binding]; other site
889513005335	dimer interface [polypeptide binding]; other site
889513005336	inhibitor binding site; inhibition site
889513005337	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
889513005338	GTP cyclohydrolase I; Provisional; Region: PLN03044
889513005339	homodecamer interface [polypeptide binding]; other site
889513005340	active site
889513005341	putative catalytic site residues [active]
889513005342	zinc binding site [ion binding]; other site
889513005343	GTP-CH-I/GFRP interaction surface; other site
889513005344	FtsH Extracellular; Region: FtsH_ext; pfam06480
889513005345	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
889513005346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513005347	Walker A motif; other site
889513005348	ATP binding site [chemical binding]; other site
889513005349	Walker B motif; other site
889513005350	arginine finger; other site
889513005351	Peptidase family M41; Region: Peptidase_M41; pfam01434
889513005352	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513005353	active site
889513005354	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
889513005355	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
889513005356	Ligand Binding Site [chemical binding]; other site
889513005357	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
889513005358	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
889513005359	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
889513005360	dimer interface [polypeptide binding]; other site
889513005361	substrate binding site [chemical binding]; other site
889513005362	metal binding sites [ion binding]; metal-binding site
889513005363	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
889513005364	active site residue [active]
889513005365	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889513005366	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
889513005367	Secretory lipase; Region: LIP; pfam03583
889513005368	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889513005369	MarR family; Region: MarR_2; pfam12802
889513005370	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889513005371	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
889513005372	acyl-activating enzyme (AAE) consensus motif; other site
889513005373	AMP binding site [chemical binding]; other site
889513005374	active site
889513005375	CoA binding site [chemical binding]; other site
889513005376	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
889513005377	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
889513005378	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889513005379	putative trimer interface [polypeptide binding]; other site
889513005380	putative CoA binding site [chemical binding]; other site
889513005381	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889513005382	putative trimer interface [polypeptide binding]; other site
889513005383	putative CoA binding site [chemical binding]; other site
889513005384	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
889513005385	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
889513005386	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
889513005387	ring oligomerisation interface [polypeptide binding]; other site
889513005388	ATP/Mg binding site [chemical binding]; other site
889513005389	stacking interactions; other site
889513005390	hinge regions; other site
889513005391	hypothetical protein; Provisional; Region: PRK07907
889513005392	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
889513005393	active site
889513005394	metal binding site [ion binding]; metal-binding site
889513005395	dimer interface [polypeptide binding]; other site
889513005396	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
889513005397	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889513005398	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
889513005399	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
889513005400	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
889513005401	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
889513005402	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
889513005403	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889513005404	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
889513005405	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
889513005406	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
889513005407	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
889513005408	carboxylate-amine ligase; Provisional; Region: PRK13517
889513005409	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
889513005410	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
889513005411	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
889513005412	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
889513005413	active site
889513005414	catalytic residues [active]
889513005415	metal binding site [ion binding]; metal-binding site
889513005416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889513005417	Coenzyme A binding pocket [chemical binding]; other site
889513005418	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
889513005419	putative catalytic site [active]
889513005420	putative phosphate binding site [ion binding]; other site
889513005421	active site
889513005422	metal binding site A [ion binding]; metal-binding site
889513005423	DNA binding site [nucleotide binding]
889513005424	putative AP binding site [nucleotide binding]; other site
889513005425	putative metal binding site B [ion binding]; other site
889513005426	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
889513005427	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
889513005428	putative active site [active]
889513005429	catalytic site [active]
889513005430	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
889513005431	putative active site [active]
889513005432	catalytic site [active]
889513005433	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
889513005434	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
889513005435	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
889513005436	Walker A/P-loop; other site
889513005437	ATP binding site [chemical binding]; other site
889513005438	Q-loop/lid; other site
889513005439	ABC transporter signature motif; other site
889513005440	Walker B; other site
889513005441	D-loop; other site
889513005442	H-loop/switch region; other site
889513005443	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
889513005444	nudix motif; other site
889513005445	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
889513005446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
889513005447	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889513005448	substrate binding pocket [chemical binding]; other site
889513005449	membrane-bound complex binding site; other site
889513005450	hinge residues; other site
889513005451	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
889513005452	Catalytic domain of Protein Kinases; Region: PKc; cd00180
889513005453	active site
889513005454	ATP binding site [chemical binding]; other site
889513005455	substrate binding site [chemical binding]; other site
889513005456	activation loop (A-loop); other site
889513005457	propionate/acetate kinase; Provisional; Region: PRK12379
889513005458	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
889513005459	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
889513005460	ferredoxin-NADP+ reductase; Region: PLN02852
889513005461	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889513005462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
889513005463	Coenzyme A binding pocket [chemical binding]; other site
889513005464	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
889513005465	active site
889513005466	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
889513005467	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889513005468	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513005469	active site
889513005470	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
889513005471	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
889513005472	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
889513005473	catalytic residues [active]
889513005474	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
889513005475	ResB-like family; Region: ResB; pfam05140
889513005476	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
889513005477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889513005478	TPR motif; other site
889513005479	TPR repeat; Region: TPR_11; pfam13414
889513005480	binding surface
889513005481	Cytochrome c552; Region: Cytochrom_C552; pfam02335
889513005482	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
889513005483	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
889513005484	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
889513005485	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
889513005486	GDP-binding site [chemical binding]; other site
889513005487	ACT binding site; other site
889513005488	IMP binding site; other site
889513005489	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
889513005490	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
889513005491	Walker A/P-loop; other site
889513005492	ATP binding site [chemical binding]; other site
889513005493	Q-loop/lid; other site
889513005494	ABC transporter signature motif; other site
889513005495	Walker B; other site
889513005496	D-loop; other site
889513005497	H-loop/switch region; other site
889513005498	Predicted transcriptional regulators [Transcription]; Region: COG1695
889513005499	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
889513005500	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
889513005501	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
889513005502	active site
889513005503	intersubunit interface [polypeptide binding]; other site
889513005504	zinc binding site [ion binding]; other site
889513005505	Na+ binding site [ion binding]; other site
889513005506	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
889513005507	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
889513005508	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
889513005509	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889513005510	active site
889513005511	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
889513005512	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
889513005513	active site residue [active]
889513005514	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
889513005515	active site residue [active]
889513005516	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
889513005517	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
889513005518	Gram positive anchor; Region: Gram_pos_anchor; cl15427
889513005519	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
889513005520	active site
889513005521	catalytic site [active]
889513005522	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
889513005523	Cna protein B-type domain; Region: Cna_B; pfam05738
889513005524	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
889513005525	active site
889513005526	catalytic site [active]
889513005527	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
889513005528	Clp amino terminal domain; Region: Clp_N; pfam02861
889513005529	Clp amino terminal domain; Region: Clp_N; pfam02861
889513005530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513005531	Walker A motif; other site
889513005532	ATP binding site [chemical binding]; other site
889513005533	Walker B motif; other site
889513005534	arginine finger; other site
889513005535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889513005536	Walker A motif; other site
889513005537	ATP binding site [chemical binding]; other site
889513005538	Walker B motif; other site
889513005539	arginine finger; other site
889513005540	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
889513005541	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
889513005542	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
889513005543	Walker A/P-loop; other site
889513005544	ATP binding site [chemical binding]; other site
889513005545	Q-loop/lid; other site
889513005546	ABC transporter signature motif; other site
889513005547	Walker B; other site
889513005548	D-loop; other site
889513005549	H-loop/switch region; other site
889513005550	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
889513005551	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
889513005552	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
889513005553	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
889513005554	FAD binding pocket [chemical binding]; other site
889513005555	conserved FAD binding motif [chemical binding]; other site
889513005556	phosphate binding motif [ion binding]; other site
889513005557	beta-alpha-beta structure motif; other site
889513005558	NAD binding pocket [chemical binding]; other site
889513005559	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
889513005560	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
889513005561	FtsX-like permease family; Region: FtsX; pfam02687
889513005562	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
889513005563	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889513005564	Walker A/P-loop; other site
889513005565	ATP binding site [chemical binding]; other site
889513005566	Q-loop/lid; other site
889513005567	ABC transporter signature motif; other site
889513005568	Walker B; other site
889513005569	D-loop; other site
889513005570	H-loop/switch region; other site
889513005571	HlyD family secretion protein; Region: HlyD_3; pfam13437
889513005572	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
889513005573	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
889513005574	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
889513005575	NAD binding site [chemical binding]; other site
889513005576	substrate binding site [chemical binding]; other site
889513005577	catalytic Zn binding site [ion binding]; other site
889513005578	tetramer interface [polypeptide binding]; other site
889513005579	structural Zn binding site [ion binding]; other site
889513005580	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
889513005581	active site
889513005582	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
889513005583	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
889513005584	DNA binding residues [nucleotide binding]
889513005585	chaperone protein DnaJ; Provisional; Region: PRK14279
889513005586	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
889513005587	HSP70 interaction site [polypeptide binding]; other site
889513005588	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
889513005589	Zn binding sites [ion binding]; other site
889513005590	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
889513005591	dimer interface [polypeptide binding]; other site
889513005592	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
889513005593	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
889513005594	dimer interface [polypeptide binding]; other site
889513005595	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
889513005596	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
889513005597	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
889513005598	nucleotide binding site [chemical binding]; other site
889513005599	NEF interaction site [polypeptide binding]; other site
889513005600	SBD interface [polypeptide binding]; other site
889513005601	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
889513005602	active site
889513005603	catalytic site [active]
889513005604	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
889513005605	Domain of unknown function DUF20; Region: UPF0118; pfam01594
889513005606	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513005607	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
889513005608	Walker A/P-loop; other site
889513005609	ATP binding site [chemical binding]; other site
889513005610	Q-loop/lid; other site
889513005611	ABC transporter signature motif; other site
889513005612	Walker B; other site
889513005613	D-loop; other site
889513005614	H-loop/switch region; other site
889513005615	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513005616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513005617	dimer interface [polypeptide binding]; other site
889513005618	conserved gate region; other site
889513005619	putative PBP binding loops; other site
889513005620	ABC-ATPase subunit interface; other site
889513005621	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
889513005622	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
889513005623	adrenodoxin reductase; Provisional; Region: PTZ00188
889513005624	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
889513005625	4Fe-4S binding domain; Region: Fer4; cl02805
889513005626	4Fe-4S binding domain; Region: Fer4; pfam00037
889513005627	Cysteine-rich domain; Region: CCG; pfam02754
889513005628	Cysteine-rich domain; Region: CCG; pfam02754
889513005629	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
889513005630	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889513005631	dimerization interface [polypeptide binding]; other site
889513005632	putative DNA binding site [nucleotide binding]; other site
889513005633	putative Zn2+ binding site [ion binding]; other site
889513005634	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513005635	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513005636	Walker A/P-loop; other site
889513005637	ATP binding site [chemical binding]; other site
889513005638	Q-loop/lid; other site
889513005639	ABC transporter signature motif; other site
889513005640	Walker B; other site
889513005641	D-loop; other site
889513005642	H-loop/switch region; other site
889513005643	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
889513005644	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513005645	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513005646	putative PBP binding regions; other site
889513005647	ABC-ATPase subunit  interface; other site
889513005648	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
889513005649	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889513005650	intersubunit interface [polypeptide binding]; other site
889513005651	UreD urease accessory protein; Region: UreD; cl00530
889513005652	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
889513005653	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
889513005654	UreF; Region: UreF; pfam01730
889513005655	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
889513005656	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
889513005657	dimer interface [polypeptide binding]; other site
889513005658	catalytic residues [active]
889513005659	urease subunit alpha; Reviewed; Region: ureC; PRK13207
889513005660	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
889513005661	subunit interactions [polypeptide binding]; other site
889513005662	active site
889513005663	flap region; other site
889513005664	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
889513005665	gamma-beta subunit interface [polypeptide binding]; other site
889513005666	alpha-beta subunit interface [polypeptide binding]; other site
889513005667	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
889513005668	alpha-gamma subunit interface [polypeptide binding]; other site
889513005669	beta-gamma subunit interface [polypeptide binding]; other site
889513005670	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889513005671	EamA-like transporter family; Region: EamA; pfam00892
889513005672	EamA-like transporter family; Region: EamA; pfam00892
889513005673	aminotransferase AlaT; Validated; Region: PRK09265
889513005674	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889513005675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513005676	homodimer interface [polypeptide binding]; other site
889513005677	catalytic residue [active]
889513005678	YibE/F-like protein; Region: YibE_F; pfam07907
889513005679	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
889513005680	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
889513005681	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
889513005682	dimer interface [polypeptide binding]; other site
889513005683	putative anticodon binding site; other site
889513005684	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889513005685	motif 1; other site
889513005686	dimer interface [polypeptide binding]; other site
889513005687	active site
889513005688	motif 2; other site
889513005689	motif 3; other site
889513005690	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
889513005691	Protein of unknown function (DUF998); Region: DUF998; pfam06197
889513005692	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
889513005693	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
889513005694	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
889513005695	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
889513005696	trimer interface [polypeptide binding]; other site
889513005697	active site
889513005698	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889513005699	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
889513005700	NAD(P) binding site [chemical binding]; other site
889513005701	catalytic residues [active]
889513005702	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
889513005703	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
889513005704	VanW like protein; Region: VanW; pfam04294
889513005705	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
889513005706	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
889513005707	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
889513005708	Acyltransferase family; Region: Acyl_transf_3; pfam01757
889513005709	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
889513005710	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889513005711	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
889513005712	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513005713	S-adenosylmethionine binding site [chemical binding]; other site
889513005714	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
889513005715	active site
889513005716	substrate-binding site [chemical binding]; other site
889513005717	metal-binding site [ion binding]
889513005718	GTP binding site [chemical binding]; other site
889513005719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889513005720	S-adenosylmethionine binding site [chemical binding]; other site
889513005721	LabA_like proteins; Region: LabA_like; cd06167
889513005722	putative metal binding site [ion binding]; other site
889513005723	MMPL family; Region: MMPL; pfam03176
889513005724	MMPL family; Region: MMPL; pfam03176
889513005725	Predicted integral membrane protein [Function unknown]; Region: COG0392
889513005726	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
889513005727	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
889513005728	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
889513005729	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
889513005730	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
889513005731	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
889513005732	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
889513005733	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
889513005734	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
889513005735	active site
889513005736	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
889513005737	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
889513005738	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
889513005739	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
889513005740	acyl-activating enzyme (AAE) consensus motif; other site
889513005741	active site
889513005742	Cutinase; Region: Cutinase; pfam01083
889513005743	Putative esterase; Region: Esterase; pfam00756
889513005744	S-formylglutathione hydrolase; Region: PLN02442
889513005745	LGFP repeat; Region: LGFP; pfam08310
889513005746	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
889513005747	LGFP repeat; Region: LGFP; pfam08310
889513005748	LGFP repeat; Region: LGFP; pfam08310
889513005749	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
889513005750	Predicted esterase [General function prediction only]; Region: COG0627
889513005751	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
889513005752	UbiA prenyltransferase family; Region: UbiA; pfam01040
889513005753	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889513005754	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
889513005755	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
889513005756	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
889513005757	Repair protein; Region: Repair_PSII; pfam04536
889513005758	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
889513005759	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889513005760	active site
889513005761	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
889513005762	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
889513005763	active site
889513005764	catalytic site [active]
889513005765	metal binding site [ion binding]; metal-binding site
889513005766	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
889513005767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005768	putative substrate translocation pore; other site
889513005769	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
889513005770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889513005771	UDP-galactopyranose mutase; Region: GLF; pfam03275
889513005772	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889513005773	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889513005774	Walker A/P-loop; other site
889513005775	ATP binding site [chemical binding]; other site
889513005776	Q-loop/lid; other site
889513005777	ABC transporter signature motif; other site
889513005778	Walker B; other site
889513005779	D-loop; other site
889513005780	H-loop/switch region; other site
889513005781	FecCD transport family; Region: FecCD; pfam01032
889513005782	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889513005783	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889513005784	putative PBP binding regions; other site
889513005785	ABC-ATPase subunit  interface; other site
889513005786	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
889513005787	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
889513005788	putative binding site residues; other site
889513005789	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
889513005790	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
889513005791	amidase catalytic site [active]
889513005792	Zn binding residues [ion binding]; other site
889513005793	substrate binding site [chemical binding]; other site
889513005794	LGFP repeat; Region: LGFP; pfam08310
889513005795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513005796	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
889513005797	active site
889513005798	motif I; other site
889513005799	motif II; other site
889513005800	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889513005801	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889513005802	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
889513005803	putative acyl-acceptor binding pocket; other site
889513005804	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
889513005805	seryl-tRNA synthetase; Provisional; Region: PRK05431
889513005806	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
889513005807	dimer interface [polypeptide binding]; other site
889513005808	active site
889513005809	motif 1; other site
889513005810	motif 2; other site
889513005811	motif 3; other site
889513005812	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
889513005813	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889513005814	DNA-binding site [nucleotide binding]; DNA binding site
889513005815	UTRA domain; Region: UTRA; pfam07702
889513005816	Septum formation; Region: Septum_form; pfam13845
889513005817	Septum formation; Region: Septum_form; pfam13845
889513005818	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
889513005819	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889513005820	catalytic core [active]
889513005821	Prephenate dehydratase; Region: PDT; pfam00800
889513005822	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
889513005823	putative L-Phe binding site [chemical binding]; other site
889513005824	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
889513005825	Amidase; Region: Amidase; cl11426
889513005826	CAAX protease self-immunity; Region: Abi; pfam02517
889513005827	Transcriptional regulator [Transcription]; Region: LytR; COG1316
889513005828	Htaa; Region: HtaA; pfam04213
889513005829	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
889513005830	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
889513005831	putative active site [active]
889513005832	catalytic site [active]
889513005833	putative metal binding site [ion binding]; other site
889513005834	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
889513005835	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
889513005836	Nucleoside recognition; Region: Gate; pfam07670
889513005837	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
889513005838	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
889513005839	active site
889513005840	catalytic motif [active]
889513005841	Zn binding site [ion binding]; other site
889513005842	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
889513005843	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
889513005844	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
889513005845	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
889513005846	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
889513005847	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
889513005848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
889513005849	NAD binding site [chemical binding]; other site
889513005850	dimer interface [polypeptide binding]; other site
889513005851	substrate binding site [chemical binding]; other site
889513005852	methionine sulfoxide reductase A; Provisional; Region: PRK00058
889513005853	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
889513005854	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
889513005855	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
889513005856	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889513005857	Predicted flavoprotein [General function prediction only]; Region: COG0431
889513005858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005859	putative substrate translocation pore; other site
889513005860	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889513005861	Abi-like protein; Region: Abi_2; pfam07751
889513005862	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
889513005863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005865	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
889513005866	homodimer interface [polypeptide binding]; other site
889513005867	chemical substrate binding site [chemical binding]; other site
889513005868	oligomer interface [polypeptide binding]; other site
889513005869	metal binding site [ion binding]; metal-binding site
889513005870	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
889513005871	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
889513005872	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
889513005873	Lsr2; Region: Lsr2; pfam11774
889513005874	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889513005875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513005876	active site
889513005877	phosphorylation site [posttranslational modification]
889513005878	intermolecular recognition site; other site
889513005879	dimerization interface [polypeptide binding]; other site
889513005880	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889513005881	DNA binding residues [nucleotide binding]
889513005882	dimerization interface [polypeptide binding]; other site
889513005883	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
889513005884	Histidine kinase; Region: HisKA_3; pfam07730
889513005885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889513005886	ATP binding site [chemical binding]; other site
889513005887	Mg2+ binding site [ion binding]; other site
889513005888	G-X-G motif; other site
889513005889	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
889513005890	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
889513005891	active site
889513005892	catalytic site [active]
889513005893	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
889513005894	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
889513005895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889513005896	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889513005897	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
889513005898	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889513005899	Ligand Binding Site [chemical binding]; other site
889513005900	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889513005901	Ligand Binding Site [chemical binding]; other site
889513005902	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
889513005903	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
889513005904	active site
889513005905	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
889513005906	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
889513005907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889513005908	Walker A/P-loop; other site
889513005909	ATP binding site [chemical binding]; other site
889513005910	Q-loop/lid; other site
889513005911	ABC transporter signature motif; other site
889513005912	Walker B; other site
889513005913	D-loop; other site
889513005914	H-loop/switch region; other site
889513005915	Predicted transcriptional regulators [Transcription]; Region: COG1725
889513005916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889513005917	DNA-binding site [nucleotide binding]; DNA binding site
889513005918	LabA_like proteins; Region: LabA_like; cd06167
889513005919	putative metal binding site [ion binding]; other site
889513005920	Uncharacterized conserved protein [Function unknown]; Region: COG1432
889513005921	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
889513005922	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
889513005923	catalytic residues [active]
889513005924	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
889513005925	metal-binding site [ion binding]
889513005926	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
889513005927	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
889513005928	metal-binding site [ion binding]
889513005929	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
889513005930	benzoate transport; Region: 2A0115; TIGR00895
889513005931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005932	putative substrate translocation pore; other site
889513005933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889513005934	replicative DNA helicase; Provisional; Region: PRK05636
889513005935	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
889513005936	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
889513005937	Walker A motif; other site
889513005938	ATP binding site [chemical binding]; other site
889513005939	Walker B motif; other site
889513005940	DNA binding loops [nucleotide binding]
889513005941	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
889513005942	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
889513005943	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
889513005944	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
889513005945	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
889513005946	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
889513005947	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
889513005948	dimer interface [polypeptide binding]; other site
889513005949	ssDNA binding site [nucleotide binding]; other site
889513005950	tetramer (dimer of dimers) interface [polypeptide binding]; other site
889513005951	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
889513005952	Predicted integral membrane protein [Function unknown]; Region: COG5650
889513005953	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
889513005954	Transglycosylase; Region: Transgly; pfam00912
889513005955	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
889513005956	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889513005957	MarR family; Region: MarR; pfam01047
889513005958	MarR family; Region: MarR_2; cl17246
889513005959	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889513005960	Ligand Binding Site [chemical binding]; other site
889513005961	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889513005962	Ligand Binding Site [chemical binding]; other site
889513005963	short chain dehydrogenase; Provisional; Region: PRK08219
889513005964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889513005965	NAD(P) binding site [chemical binding]; other site
889513005966	active site
889513005967	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
889513005968	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
889513005969	active site residue [active]
889513005970	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
889513005971	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
889513005972	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
889513005973	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
889513005974	dimerization interface [polypeptide binding]; other site
889513005975	DPS ferroxidase diiron center [ion binding]; other site
889513005976	ion pore; other site
889513005977	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
889513005978	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
889513005979	putative DNA binding site [nucleotide binding]; other site
889513005980	catalytic residue [active]
889513005981	putative H2TH interface [polypeptide binding]; other site
889513005982	putative catalytic residues [active]
889513005983	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
889513005984	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
889513005985	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
889513005986	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
889513005987	putative substrate binding site [chemical binding]; other site
889513005988	putative ATP binding site [chemical binding]; other site
889513005989	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
889513005990	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
889513005991	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
889513005992	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
889513005993	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
889513005994	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
889513005995	HIGH motif; other site
889513005996	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
889513005997	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513005998	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889513005999	active site
889513006000	KMSKS motif; other site
889513006001	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
889513006002	tRNA binding surface [nucleotide binding]; other site
889513006003	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
889513006004	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889513006005	Walker A/P-loop; other site
889513006006	ATP binding site [chemical binding]; other site
889513006007	Q-loop/lid; other site
889513006008	ABC transporter signature motif; other site
889513006009	Walker B; other site
889513006010	D-loop; other site
889513006011	H-loop/switch region; other site
889513006012	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
889513006013	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
889513006014	FtsX-like permease family; Region: FtsX; pfam02687
889513006015	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513006016	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513006017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
889513006018	Histidine kinase; Region: HisKA_3; pfam07730
889513006019	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
889513006020	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889513006021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889513006022	active site
889513006023	phosphorylation site [posttranslational modification]
889513006024	intermolecular recognition site; other site
889513006025	dimerization interface [polypeptide binding]; other site
889513006026	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889513006027	DNA binding residues [nucleotide binding]
889513006028	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513006029	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
889513006030	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513006031	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
889513006032	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
889513006033	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
889513006034	active site
889513006035	trimer interface [polypeptide binding]; other site
889513006036	allosteric site; other site
889513006037	active site lid [active]
889513006038	hexamer (dimer of trimers) interface [polypeptide binding]; other site
889513006039	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
889513006040	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
889513006041	active site
889513006042	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
889513006043	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
889513006044	putative active site cavity [active]
889513006045	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
889513006046	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
889513006047	nucleotide binding site [chemical binding]; other site
889513006048	Transcriptional regulators [Transcription]; Region: FadR; COG2186
889513006049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889513006050	DNA-binding site [nucleotide binding]; DNA binding site
889513006051	FCD domain; Region: FCD; pfam07729
889513006052	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
889513006053	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
889513006054	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889513006055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513006056	dimer interface [polypeptide binding]; other site
889513006057	conserved gate region; other site
889513006058	putative PBP binding loops; other site
889513006059	ABC-ATPase subunit interface; other site
889513006060	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
889513006061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889513006062	dimer interface [polypeptide binding]; other site
889513006063	conserved gate region; other site
889513006064	putative PBP binding loops; other site
889513006065	ABC-ATPase subunit interface; other site
889513006066	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
889513006067	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513006068	Walker A/P-loop; other site
889513006069	ATP binding site [chemical binding]; other site
889513006070	Q-loop/lid; other site
889513006071	ABC transporter signature motif; other site
889513006072	Walker B; other site
889513006073	D-loop; other site
889513006074	H-loop/switch region; other site
889513006075	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
889513006076	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
889513006077	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889513006078	Walker A/P-loop; other site
889513006079	ATP binding site [chemical binding]; other site
889513006080	Q-loop/lid; other site
889513006081	ABC transporter signature motif; other site
889513006082	Walker B; other site
889513006083	D-loop; other site
889513006084	H-loop/switch region; other site
889513006085	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889513006086	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
889513006087	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
889513006088	inhibitor site; inhibition site
889513006089	active site
889513006090	dimer interface [polypeptide binding]; other site
889513006091	catalytic residue [active]
889513006092	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
889513006093	active site
889513006094	catalytic residues [active]
889513006095	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
889513006096	hypothetical protein; Provisional; Region: PRK13663
889513006097	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
889513006098	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
889513006099	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
889513006100	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889513006101	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
889513006102	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
889513006103	substrate binding pocket [chemical binding]; other site
889513006104	substrate-Mg2+ binding site; other site
889513006105	aspartate-rich region 1; other site
889513006106	aspartate-rich region 2; other site
889513006107	phytoene desaturase; Region: crtI_fam; TIGR02734
889513006108	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889513006109	SdpI/YhfL protein family; Region: SdpI; pfam13630
889513006110	anthranilate synthase component I; Provisional; Region: PRK13564
889513006111	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
889513006112	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
889513006113	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
889513006114	Glutamine amidotransferase class-I; Region: GATase; pfam00117
889513006115	glutamine binding [chemical binding]; other site
889513006116	catalytic triad [active]
889513006117	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
889513006118	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
889513006119	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
889513006120	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
889513006121	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
889513006122	active site
889513006123	ribulose/triose binding site [chemical binding]; other site
889513006124	phosphate binding site [ion binding]; other site
889513006125	substrate (anthranilate) binding pocket [chemical binding]; other site
889513006126	product (indole) binding pocket [chemical binding]; other site
889513006127	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
889513006128	active site
889513006129	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
889513006130	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
889513006131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889513006132	catalytic residue [active]
889513006133	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
889513006134	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
889513006135	substrate binding site [chemical binding]; other site
889513006136	active site
889513006137	catalytic residues [active]
889513006138	heterodimer interface [polypeptide binding]; other site
889513006139	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
889513006140	iron-sulfur cluster [ion binding]; other site
889513006141	[2Fe-2S] cluster binding site [ion binding]; other site
889513006142	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
889513006143	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
889513006144	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
889513006145	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
889513006146	hypothetical protein; Validated; Region: PRK00228
889513006147	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
889513006148	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
889513006149	active site
889513006150	NTP binding site [chemical binding]; other site
889513006151	metal binding triad [ion binding]; metal-binding site
889513006152	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
889513006153	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889513006154	Zn2+ binding site [ion binding]; other site
889513006155	Mg2+ binding site [ion binding]; other site
889513006156	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
889513006157	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
889513006158	active site
889513006159	Ap6A binding site [chemical binding]; other site
889513006160	nudix motif; other site
889513006161	metal binding site [ion binding]; metal-binding site
889513006162	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
889513006163	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
889513006164	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
889513006165	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889513006166	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889513006167	DNA binding residues [nucleotide binding]
889513006168	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
889513006169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889513006170	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889513006171	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
889513006172	catalytic residues [active]
889513006173	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
889513006174	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
889513006175	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
889513006176	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
889513006177	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
889513006178	active site
889513006179	metal binding site [ion binding]; metal-binding site
889513006180	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
889513006181	ParB-like nuclease domain; Region: ParBc; pfam02195
889513006182	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889513006183	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889513006184	P-loop; other site
889513006185	Magnesium ion binding site [ion binding]; other site
889513006186	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889513006187	Magnesium ion binding site [ion binding]; other site
889513006188	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
889513006189	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
889513006190	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
889513006191	Haemolytic domain; Region: Haemolytic; pfam01809
889513006192	ribonuclease P; Reviewed; Region: rnpA; PRK03459
889513006193	Ribosomal protein L34; Region: Ribosomal_L34; cl00370