-- dump date   	20140619_052709
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1117942000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
1117942000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942000003	Walker A motif; other site
1117942000004	ATP binding site [chemical binding]; other site
1117942000005	Walker B motif; other site
1117942000006	arginine finger; other site
1117942000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1117942000008	DnaA box-binding interface [nucleotide binding]; other site
1117942000009	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1117942000010	DNA polymerase III beta subunit; Region: POL3Bc; smart00480
1117942000011	putative DNA binding surface [nucleotide binding]; other site
1117942000012	dimer interface [polypeptide binding]; other site
1117942000013	beta-clamp/translesion DNA polymerase binding surface; other site
1117942000014	beta-clamp/clamp loader binding surface; other site
1117942000015	recombination protein F; Reviewed; Region: recF; PRK00064
1117942000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1117942000017	Walker A/P-loop; other site
1117942000018	ATP binding site [chemical binding]; other site
1117942000019	Q-loop/lid; other site
1117942000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942000021	ABC transporter signature motif; other site
1117942000022	Walker B; other site
1117942000023	D-loop; other site
1117942000024	H-loop/switch region; other site
1117942000025	hypothetical protein; Provisional; Region: PRK00111
1117942000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1117942000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117942000028	ATP binding site [chemical binding]; other site
1117942000029	Mg2+ binding site [ion binding]; other site
1117942000030	G-X-G motif; other site
1117942000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1117942000032	anchoring element; other site
1117942000033	dimer interface [polypeptide binding]; other site
1117942000034	ATP binding site [chemical binding]; other site
1117942000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1117942000036	active site
1117942000037	putative metal-binding site [ion binding]; other site
1117942000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1117942000039	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1117942000040	metal binding site [ion binding]; metal-binding site
1117942000041	DNA gyrase subunit A; Validated; Region: PRK05560
1117942000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1117942000043	CAP-like domain; other site
1117942000044	active site
1117942000045	primary dimer interface [polypeptide binding]; other site
1117942000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117942000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117942000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117942000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117942000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117942000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1117942000052	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1117942000053	YwiC-like protein; Region: YwiC; pfam14256
1117942000054	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1117942000055	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1117942000056	putative ligand binding site [chemical binding]; other site
1117942000057	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1117942000058	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1117942000059	TM-ABC transporter signature motif; other site
1117942000060	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1117942000061	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1117942000062	Walker A/P-loop; other site
1117942000063	ATP binding site [chemical binding]; other site
1117942000064	Q-loop/lid; other site
1117942000065	ABC transporter signature motif; other site
1117942000066	Walker B; other site
1117942000067	D-loop; other site
1117942000068	H-loop/switch region; other site
1117942000069	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1117942000070	active site
1117942000071	Rhomboid family; Region: Rhomboid; pfam01694
1117942000072	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
1117942000073	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1117942000074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1117942000075	Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576
1117942000076	putative active site [active]
1117942000077	catalytic site [active]
1117942000078	Mg binding site [ion binding]; other site
1117942000079	catalytic loop [active]
1117942000080	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117942000081	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942000082	Walker A/P-loop; other site
1117942000083	ATP binding site [chemical binding]; other site
1117942000084	Q-loop/lid; other site
1117942000085	ABC transporter signature motif; other site
1117942000086	Walker B; other site
1117942000087	D-loop; other site
1117942000088	H-loop/switch region; other site
1117942000089	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1117942000090	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942000091	ABC-ATPase subunit  interface; other site
1117942000092	dimer interface [polypeptide binding]; other site
1117942000093	putative PBP binding regions; other site
1117942000094	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942000095	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942000096	ABC-ATPase subunit  interface; other site
1117942000097	dimer interface [polypeptide binding]; other site
1117942000098	putative PBP binding regions; other site
1117942000099	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
1117942000100	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1117942000101	siderophore binding site; other site
1117942000102	putative septation inhibitor protein; Reviewed; Region: PRK00159
1117942000103	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1117942000104	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117942000105	active site
1117942000106	ATP binding site [chemical binding]; other site
1117942000107	substrate binding site [chemical binding]; other site
1117942000108	activation loop (A-loop); other site
1117942000109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1117942000110	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942000111	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942000112	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942000113	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942000114	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1117942000115	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117942000116	active site
1117942000117	ATP binding site [chemical binding]; other site
1117942000118	substrate binding site [chemical binding]; other site
1117942000119	activation loop (A-loop); other site
1117942000120	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1117942000121	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1117942000122	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1117942000123	Protein phosphatase 2C; Region: PP2C; pfam00481
1117942000124	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1117942000125	active site
1117942000126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117942000127	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117942000128	phosphopeptide binding site; other site
1117942000129	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1117942000130	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117942000131	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117942000132	phosphopeptide binding site; other site
1117942000133	CAAX protease self-immunity; Region: Abi; pfam02517
1117942000134	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1117942000135	Predicted transcriptional regulators [Transcription]; Region: COG1695
1117942000136	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1117942000137	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1117942000138	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942000139	intersubunit interface [polypeptide binding]; other site
1117942000140	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117942000141	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942000142	Walker A/P-loop; other site
1117942000143	ATP binding site [chemical binding]; other site
1117942000144	Q-loop/lid; other site
1117942000145	ABC transporter signature motif; other site
1117942000146	Walker B; other site
1117942000147	D-loop; other site
1117942000148	H-loop/switch region; other site
1117942000149	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942000150	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942000151	ABC-ATPase subunit  interface; other site
1117942000152	dimer interface [polypeptide binding]; other site
1117942000153	putative PBP binding regions; other site
1117942000154	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1117942000155	MgtE intracellular N domain; Region: MgtE_N; smart00924
1117942000156	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1117942000157	Divalent cation transporter; Region: MgtE; pfam01769
1117942000158	trehalose synthase; Region: treS_nterm; TIGR02456
1117942000159	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348
1117942000160	active site
1117942000161	catalytic site [active]
1117942000162	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1117942000163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942000164	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942000165	putative substrate translocation pore; other site
1117942000166	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1117942000167	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
1117942000168	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942000169	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942000170	DNA binding residues [nucleotide binding]
1117942000171	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1117942000172	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1117942000173	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1117942000174	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1117942000175	catalytic residues [active]
1117942000176	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1117942000177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942000178	dimer interface [polypeptide binding]; other site
1117942000179	conserved gate region; other site
1117942000180	putative PBP binding loops; other site
1117942000181	ABC-ATPase subunit interface; other site
1117942000182	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1117942000183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942000184	Walker A/P-loop; other site
1117942000185	ATP binding site [chemical binding]; other site
1117942000186	Q-loop/lid; other site
1117942000187	ABC transporter signature motif; other site
1117942000188	Walker B; other site
1117942000189	D-loop; other site
1117942000190	H-loop/switch region; other site
1117942000191	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1117942000192	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1117942000193	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
1117942000194	putative metal binding site [ion binding]; other site
1117942000195	biotin synthase; Validated; Region: PRK06256
1117942000196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942000197	FeS/SAM binding site; other site
1117942000198	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1117942000199	MepB protein; Region: MepB; cl01985
1117942000200	AMP nucleosidase; Provisional; Region: PRK08292
1117942000201	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1117942000202	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1117942000203	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1117942000204	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1117942000205	active site
1117942000206	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1117942000207	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1117942000208	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1117942000209	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1117942000210	Lipase (class 2); Region: Lipase_2; pfam01674
1117942000211	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
1117942000212	dimer interface [polypeptide binding]; other site
1117942000213	FMN binding site [chemical binding]; other site
1117942000214	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1117942000215	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1117942000216	trimer interface [polypeptide binding]; other site
1117942000217	putative metal binding site [ion binding]; other site
1117942000218	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1117942000219	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1117942000220	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1117942000221	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1117942000222	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1117942000223	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942000224	Coenzyme A binding pocket [chemical binding]; other site
1117942000225	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1117942000226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
1117942000227	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1117942000228	MarR family; Region: MarR; pfam01047
1117942000229	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1117942000230	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1117942000231	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1117942000232	hypothetical protein; Provisional; Region: PRK10621
1117942000233	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117942000234	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1117942000235	active site
1117942000236	phosphorylation site [posttranslational modification]
1117942000237	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1117942000238	active site
1117942000239	P-loop; other site
1117942000240	phosphorylation site [posttranslational modification]
1117942000241	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1117942000242	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
1117942000243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942000244	ATP binding site [chemical binding]; other site
1117942000245	putative Mg++ binding site [ion binding]; other site
1117942000246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942000247	nucleotide binding region [chemical binding]; other site
1117942000248	ATP-binding site [chemical binding]; other site
1117942000249	Helicase associated domain (HA2); Region: HA2; pfam04408
1117942000250	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1117942000251	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1117942000252	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1117942000253	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1117942000254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942000255	NAD(P) binding site [chemical binding]; other site
1117942000256	active site
1117942000257	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1117942000258	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117942000259	RNA binding surface [nucleotide binding]; other site
1117942000260	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117942000261	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117942000262	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117942000263	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1117942000264	DNA binding site [nucleotide binding]
1117942000265	active site
1117942000266	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1117942000267	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1117942000268	active site
1117942000269	glycerol kinase; Provisional; Region: glpK; PRK00047
1117942000270	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1117942000271	nucleotide binding site [chemical binding]; other site
1117942000272	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1117942000273	amphipathic channel; other site
1117942000274	Asn-Pro-Ala signature motifs; other site
1117942000275	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1117942000276	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1117942000277	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1117942000278	active site
1117942000279	Zn binding site [ion binding]; other site
1117942000280	Protease prsW family; Region: PrsW-protease; pfam13367
1117942000281	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1117942000282	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1117942000283	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1117942000284	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1117942000285	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1117942000286	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1117942000287	classical (c) SDRs; Region: SDR_c; cd05233
1117942000288	NAD(P) binding site [chemical binding]; other site
1117942000289	active site
1117942000290	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1117942000291	FAD binding domain; Region: FAD_binding_4; pfam01565
1117942000292	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1117942000293	Predicted membrane protein [Function unknown]; Region: COG2246
1117942000294	GtrA-like protein; Region: GtrA; pfam04138
1117942000295	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1117942000296	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1117942000297	active site
1117942000298	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1117942000299	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1117942000300	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1117942000301	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1117942000302	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1117942000303	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942000304	ABC-ATPase subunit  interface; other site
1117942000305	dimer interface [polypeptide binding]; other site
1117942000306	putative PBP binding regions; other site
1117942000307	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942000308	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1117942000309	intersubunit interface [polypeptide binding]; other site
1117942000310	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1117942000311	active site
1117942000312	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1117942000313	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1117942000314	Walker A/P-loop; other site
1117942000315	ATP binding site [chemical binding]; other site
1117942000316	Q-loop/lid; other site
1117942000317	ABC transporter signature motif; other site
1117942000318	Walker B; other site
1117942000319	D-loop; other site
1117942000320	H-loop/switch region; other site
1117942000321	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1117942000322	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1117942000323	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1117942000324	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117942000325	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1117942000326	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1117942000327	NAD(P) binding site [chemical binding]; other site
1117942000328	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1117942000329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117942000330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942000331	homodimer interface [polypeptide binding]; other site
1117942000332	catalytic residue [active]
1117942000333	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1117942000334	transmembrane helices; other site
1117942000335	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1117942000336	CAT RNA binding domain; Region: CAT_RBD; smart01061
1117942000337	PRD domain; Region: PRD; pfam00874
1117942000338	PRD domain; Region: PRD; pfam00874
1117942000339	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117942000340	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117942000341	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1117942000342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117942000343	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
1117942000344	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1117942000345	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1117942000346	active site
1117942000347	multimer interface [polypeptide binding]; other site
1117942000348	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1117942000349	predicted active site [active]
1117942000350	catalytic triad [active]
1117942000351	prephenate dehydrogenase; Validated; Region: PRK06545
1117942000352	prephenate dehydrogenase; Validated; Region: PRK08507
1117942000353	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1117942000354	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1117942000355	nucleoside/Zn binding site; other site
1117942000356	dimer interface [polypeptide binding]; other site
1117942000357	catalytic motif [active]
1117942000358	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1117942000359	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1117942000360	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1117942000361	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1117942000362	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
1117942000363	active site
1117942000364	KMSKS motif; other site
1117942000365	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1117942000366	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1117942000367	Shikimate kinase; Region: SKI; pfam01202
1117942000368	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1117942000369	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1117942000370	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1117942000371	putative NAD(P) binding site [chemical binding]; other site
1117942000372	catalytic Zn binding site [ion binding]; other site
1117942000373	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
1117942000374	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1117942000375	NADP binding site [chemical binding]; other site
1117942000376	homodimer interface [polypeptide binding]; other site
1117942000377	active site
1117942000378	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1117942000379	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117942000380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942000381	homodimer interface [polypeptide binding]; other site
1117942000382	catalytic residue [active]
1117942000383	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1117942000384	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1117942000385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942000386	Walker A motif; other site
1117942000387	ATP binding site [chemical binding]; other site
1117942000388	Walker B motif; other site
1117942000389	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117942000390	arginine finger; other site
1117942000391	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1117942000392	hypothetical protein; Validated; Region: PRK00153
1117942000393	recombination protein RecR; Reviewed; Region: recR; PRK00076
1117942000394	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
1117942000395	RecR protein; Region: RecR; pfam02132
1117942000396	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1117942000397	putative active site [active]
1117942000398	putative metal-binding site [ion binding]; other site
1117942000399	tetramer interface [polypeptide binding]; other site
1117942000400	putative transporter; Provisional; Region: PRK09821
1117942000401	GntP family permease; Region: GntP_permease; pfam02447
1117942000402	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1117942000403	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1117942000404	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1117942000405	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117942000406	DNA-binding site [nucleotide binding]; DNA binding site
1117942000407	FCD domain; Region: FCD; pfam07729
1117942000408	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1117942000409	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1117942000410	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1117942000411	catalytic triad [active]
1117942000412	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1117942000413	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117942000414	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1117942000415	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
1117942000416	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1117942000417	active site
1117942000418	catalytic site [active]
1117942000419	substrate binding site [chemical binding]; other site
1117942000420	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
1117942000421	2-isopropylmalate synthase; Validated; Region: PRK03739
1117942000422	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1117942000423	active site
1117942000424	catalytic residues [active]
1117942000425	metal binding site [ion binding]; metal-binding site
1117942000426	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1117942000427	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1117942000428	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942000429	DNA binding residues [nucleotide binding]
1117942000430	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1117942000431	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1117942000432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942000433	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942000434	putative substrate translocation pore; other site
1117942000435	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1117942000436	intersubunit interface [polypeptide binding]; other site
1117942000437	active site
1117942000438	catalytic residue [active]
1117942000439	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1117942000440	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1117942000441	active site
1117942000442	substrate binding site [chemical binding]; other site
1117942000443	metal binding site [ion binding]; metal-binding site
1117942000444	TQXA domain; Region: TQXA_dom; TIGR03934
1117942000445	Cna protein B-type domain; Region: Cna_B; pfam05738
1117942000446	Cna protein B-type domain; Region: Cna_B; pfam05738
1117942000447	Cna protein B-type domain; Region: Cna_B; pfam05738
1117942000448	aspartate kinase; Reviewed; Region: PRK06635
1117942000449	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1117942000450	putative nucleotide binding site [chemical binding]; other site
1117942000451	putative catalytic residues [active]
1117942000452	putative Mg ion binding site [ion binding]; other site
1117942000453	putative aspartate binding site [chemical binding]; other site
1117942000454	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1117942000455	putative allosteric regulatory site; other site
1117942000456	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1117942000457	putative allosteric regulatory residue; other site
1117942000458	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1117942000459	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1117942000460	RNA polymerase sigma factor; Provisional; Region: PRK12535
1117942000461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942000462	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1117942000463	DNA binding residues [nucleotide binding]
1117942000464	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1117942000465	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1117942000466	heme binding pocket [chemical binding]; other site
1117942000467	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
1117942000468	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1117942000469	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1117942000470	Walker A/P-loop; other site
1117942000471	ATP binding site [chemical binding]; other site
1117942000472	Q-loop/lid; other site
1117942000473	ABC transporter signature motif; other site
1117942000474	Walker B; other site
1117942000475	D-loop; other site
1117942000476	H-loop/switch region; other site
1117942000477	TOBE domain; Region: TOBE_2; pfam08402
1117942000478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942000479	dimer interface [polypeptide binding]; other site
1117942000480	conserved gate region; other site
1117942000481	ABC-ATPase subunit interface; other site
1117942000482	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1117942000483	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1117942000484	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1117942000485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942000486	putative substrate translocation pore; other site
1117942000487	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117942000488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942000489	active site
1117942000490	phosphorylation site [posttranslational modification]
1117942000491	intermolecular recognition site; other site
1117942000492	dimerization interface [polypeptide binding]; other site
1117942000493	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117942000494	DNA binding site [nucleotide binding]
1117942000495	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117942000496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117942000497	dimer interface [polypeptide binding]; other site
1117942000498	phosphorylation site [posttranslational modification]
1117942000499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117942000500	ATP binding site [chemical binding]; other site
1117942000501	Mg2+ binding site [ion binding]; other site
1117942000502	G-X-G motif; other site
1117942000503	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1117942000504	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
1117942000505	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
1117942000506	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
1117942000507	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1117942000508	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
1117942000509	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
1117942000510	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1117942000511	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1117942000512	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1117942000513	Predicted membrane protein [Function unknown]; Region: COG1511
1117942000514	Predicted membrane protein [Function unknown]; Region: COG1511
1117942000515	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1117942000516	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1117942000517	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1117942000518	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1117942000519	putative active site [active]
1117942000520	putative metal binding site [ion binding]; other site
1117942000521	Yqey-like protein; Region: YqeY; pfam09424
1117942000522	Transglycosylase; Region: Transgly; pfam00912
1117942000523	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1117942000524	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1117942000525	PASTA domain; Region: PASTA; pfam03793
1117942000526	Transcription factor WhiB; Region: Whib; pfam02467
1117942000527	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1117942000528	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1117942000529	homotrimer interaction site [polypeptide binding]; other site
1117942000530	putative active site [active]
1117942000531	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1117942000532	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1117942000533	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117942000534	ligand binding site [chemical binding]; other site
1117942000535	flexible hinge region; other site
1117942000536	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1117942000537	putative switch regulator; other site
1117942000538	non-specific DNA interactions [nucleotide binding]; other site
1117942000539	DNA binding site [nucleotide binding]
1117942000540	sequence specific DNA binding site [nucleotide binding]; other site
1117942000541	putative cAMP binding site [chemical binding]; other site
1117942000542	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1117942000543	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1117942000544	minor groove reading motif; other site
1117942000545	helix-hairpin-helix signature motif; other site
1117942000546	substrate binding pocket [chemical binding]; other site
1117942000547	active site
1117942000548	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1117942000549	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1117942000550	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1117942000551	catalytic residues [active]
1117942000552	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1117942000553	putative active site [active]
1117942000554	putative CoA binding site [chemical binding]; other site
1117942000555	nudix motif; other site
1117942000556	metal binding site [ion binding]; metal-binding site
1117942000557	Colicin V production protein; Region: Colicin_V; pfam02674
1117942000558	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1117942000559	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1117942000560	active site
1117942000561	substrate binding sites [chemical binding]; other site
1117942000562	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1117942000563	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117942000564	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1117942000565	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942000566	motif II; other site
1117942000567	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1117942000568	Type II/IV secretion system protein; Region: T2SE; pfam00437
1117942000569	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1117942000570	ATP binding site [chemical binding]; other site
1117942000571	Walker A motif; other site
1117942000572	hexamer interface [polypeptide binding]; other site
1117942000573	Walker B motif; other site
1117942000574	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1117942000575	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1117942000576	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
1117942000577	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1117942000578	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942000579	ATP binding site [chemical binding]; other site
1117942000580	putative Mg++ binding site [ion binding]; other site
1117942000581	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942000582	nucleotide binding region [chemical binding]; other site
1117942000583	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1117942000584	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1117942000585	DNA-binding site [nucleotide binding]; DNA binding site
1117942000586	RNA-binding motif; other site
1117942000587	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1117942000588	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1117942000589	active site
1117942000590	interdomain interaction site; other site
1117942000591	putative metal-binding site [ion binding]; other site
1117942000592	nucleotide binding site [chemical binding]; other site
1117942000593	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1117942000594	domain I; other site
1117942000595	DNA binding groove [nucleotide binding]
1117942000596	phosphate binding site [ion binding]; other site
1117942000597	domain II; other site
1117942000598	domain III; other site
1117942000599	nucleotide binding site [chemical binding]; other site
1117942000600	catalytic site [active]
1117942000601	domain IV; other site
1117942000602	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1117942000603	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1117942000604	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1117942000605	Predicted membrane protein [Function unknown]; Region: COG1297
1117942000606	putative oligopeptide transporter, OPT family; Region: TIGR00733
1117942000607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117942000608	dimerization interface [polypeptide binding]; other site
1117942000609	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1117942000610	cyclase homology domain; Region: CHD; cd07302
1117942000611	nucleotidyl binding site; other site
1117942000612	metal binding site [ion binding]; metal-binding site
1117942000613	dimer interface [polypeptide binding]; other site
1117942000614	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1117942000615	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1117942000616	acyl-CoA synthetase; Validated; Region: PRK07788
1117942000617	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942000618	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942000619	acyl-activating enzyme (AAE) consensus motif; other site
1117942000620	acyl-activating enzyme (AAE) consensus motif; other site
1117942000621	AMP binding site [chemical binding]; other site
1117942000622	active site
1117942000623	CoA binding site [chemical binding]; other site
1117942000624	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1117942000625	active site
1117942000626	catalytic triad [active]
1117942000627	oxyanion hole [active]
1117942000628	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1117942000629	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1117942000630	substrate binding site; other site
1117942000631	tetramer interface; other site
1117942000632	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1117942000633	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1117942000634	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1117942000635	NADP binding site [chemical binding]; other site
1117942000636	active site
1117942000637	putative substrate binding site [chemical binding]; other site
1117942000638	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1117942000639	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1117942000640	NAD binding site [chemical binding]; other site
1117942000641	substrate binding site [chemical binding]; other site
1117942000642	homodimer interface [polypeptide binding]; other site
1117942000643	active site
1117942000644	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1117942000645	Zn binding site [ion binding]; other site
1117942000646	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1117942000647	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117942000648	Putative esterase; Region: Esterase; pfam00756
1117942000649	Peptidase family S64; Region: Peptidase_S64; pfam08192
1117942000650	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1117942000651	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1117942000652	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117942000653	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117942000654	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1117942000655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117942000656	non-specific DNA binding site [nucleotide binding]; other site
1117942000657	salt bridge; other site
1117942000658	sequence-specific DNA binding site [nucleotide binding]; other site
1117942000659	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1117942000660	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1117942000661	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1117942000662	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
1117942000663	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1117942000664	putative Iron-sulfur protein interface [polypeptide binding]; other site
1117942000665	proximal heme binding site [chemical binding]; other site
1117942000666	distal heme binding site [chemical binding]; other site
1117942000667	putative dimer interface [polypeptide binding]; other site
1117942000668	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
1117942000669	L-aspartate oxidase; Provisional; Region: PRK06175
1117942000670	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1117942000671	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
1117942000672	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1117942000673	Predicted membrane protein [Function unknown]; Region: COG2733
1117942000674	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1117942000675	Class I aldolases; Region: Aldolase_Class_I; cl17187
1117942000676	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1117942000677	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1117942000678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942000679	FeS/SAM binding site; other site
1117942000680	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1117942000681	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1117942000682	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1117942000683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117942000684	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1117942000685	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1117942000686	FAD binding domain; Region: FAD_binding_4; pfam01565
1117942000687	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1117942000688	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
1117942000689	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1117942000690	acyl-activating enzyme (AAE) consensus motif; other site
1117942000691	putative AMP binding site [chemical binding]; other site
1117942000692	putative active site [active]
1117942000693	putative CoA binding site [chemical binding]; other site
1117942000694	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1117942000695	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1117942000696	putative ADP-binding pocket [chemical binding]; other site
1117942000697	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942000698	catalytic core [active]
1117942000699	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942000700	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1117942000701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117942000702	dimer interface [polypeptide binding]; other site
1117942000703	phosphorylation site [posttranslational modification]
1117942000704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117942000705	ATP binding site [chemical binding]; other site
1117942000706	Mg2+ binding site [ion binding]; other site
1117942000707	G-X-G motif; other site
1117942000708	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117942000709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942000710	active site
1117942000711	phosphorylation site [posttranslational modification]
1117942000712	intermolecular recognition site; other site
1117942000713	dimerization interface [polypeptide binding]; other site
1117942000714	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117942000715	DNA binding site [nucleotide binding]
1117942000716	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1117942000717	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1117942000718	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1117942000719	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1117942000720	DNA binding domain, excisionase family; Region: excise; TIGR01764
1117942000721	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1117942000722	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1117942000723	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1117942000724	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1117942000725	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1117942000726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942000727	motif II; other site
1117942000728	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1117942000729	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1117942000730	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1117942000731	tRNA; other site
1117942000732	putative tRNA binding site [nucleotide binding]; other site
1117942000733	putative NADP binding site [chemical binding]; other site
1117942000734	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1117942000735	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1117942000736	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1117942000737	domain interfaces; other site
1117942000738	active site
1117942000739	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1117942000740	active site
1117942000741	homodimer interface [polypeptide binding]; other site
1117942000742	SAM binding site [chemical binding]; other site
1117942000743	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1117942000744	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1117942000745	active site
1117942000746	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1117942000747	dimer interface [polypeptide binding]; other site
1117942000748	active site
1117942000749	Schiff base residues; other site
1117942000750	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1117942000751	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1117942000752	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1117942000753	substrate binding site [chemical binding]; other site
1117942000754	active site
1117942000755	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1117942000756	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1117942000757	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1117942000758	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1117942000759	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117942000760	inhibitor-cofactor binding pocket; inhibition site
1117942000761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942000762	catalytic residue [active]
1117942000763	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942000764	catalytic core [active]
1117942000765	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1117942000766	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1117942000767	catalytic residues [active]
1117942000768	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1117942000769	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1117942000770	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1117942000771	ResB-like family; Region: ResB; pfam05140
1117942000772	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1117942000773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942000774	S-adenosylmethionine binding site [chemical binding]; other site
1117942000775	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117942000776	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942000777	Walker A/P-loop; other site
1117942000778	ATP binding site [chemical binding]; other site
1117942000779	Q-loop/lid; other site
1117942000780	ABC transporter signature motif; other site
1117942000781	Walker B; other site
1117942000782	D-loop; other site
1117942000783	H-loop/switch region; other site
1117942000784	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1117942000785	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942000786	intersubunit interface [polypeptide binding]; other site
1117942000787	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1117942000788	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942000789	ABC-ATPase subunit  interface; other site
1117942000790	dimer interface [polypeptide binding]; other site
1117942000791	putative PBP binding regions; other site
1117942000792	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1117942000793	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1117942000794	UbiA prenyltransferase family; Region: UbiA; pfam01040
1117942000795	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1117942000796	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942000797	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942000798	acyl-activating enzyme (AAE) consensus motif; other site
1117942000799	acyl-activating enzyme (AAE) consensus motif; other site
1117942000800	AMP binding site [chemical binding]; other site
1117942000801	active site
1117942000802	CoA binding site [chemical binding]; other site
1117942000803	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1117942000804	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117942000805	substrate binding site [chemical binding]; other site
1117942000806	oxyanion hole (OAH) forming residues; other site
1117942000807	trimer interface [polypeptide binding]; other site
1117942000808	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1117942000809	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1117942000810	active site
1117942000811	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1117942000812	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1117942000813	dimer interface [polypeptide binding]; other site
1117942000814	tetramer interface [polypeptide binding]; other site
1117942000815	PYR/PP interface [polypeptide binding]; other site
1117942000816	TPP binding site [chemical binding]; other site
1117942000817	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1117942000818	TPP-binding site; other site
1117942000819	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1117942000820	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1117942000821	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117942000822	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1117942000823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942000824	S-adenosylmethionine binding site [chemical binding]; other site
1117942000825	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1117942000826	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1117942000827	NAD(P) binding site [chemical binding]; other site
1117942000828	LDH/MDH dimer interface [polypeptide binding]; other site
1117942000829	substrate binding site [chemical binding]; other site
1117942000830	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1117942000831	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117942000832	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1117942000833	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1117942000834	substrate binding pocket [chemical binding]; other site
1117942000835	chain length determination region; other site
1117942000836	substrate-Mg2+ binding site; other site
1117942000837	catalytic residues [active]
1117942000838	aspartate-rich region 1; other site
1117942000839	active site lid residues [active]
1117942000840	aspartate-rich region 2; other site
1117942000841	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1117942000842	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1117942000843	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1117942000844	putative homodimer interface [polypeptide binding]; other site
1117942000845	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1117942000846	heterodimer interface [polypeptide binding]; other site
1117942000847	homodimer interface [polypeptide binding]; other site
1117942000848	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1117942000849	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1117942000850	23S rRNA interface [nucleotide binding]; other site
1117942000851	L7/L12 interface [polypeptide binding]; other site
1117942000852	putative thiostrepton binding site; other site
1117942000853	L25 interface [polypeptide binding]; other site
1117942000854	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1117942000855	mRNA/rRNA interface [nucleotide binding]; other site
1117942000856	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1117942000857	trimer interface [polypeptide binding]; other site
1117942000858	active site
1117942000859	G bulge; other site
1117942000860	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1117942000861	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1117942000862	FMN binding site [chemical binding]; other site
1117942000863	active site
1117942000864	substrate binding site [chemical binding]; other site
1117942000865	catalytic residue [active]
1117942000866	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1117942000867	23S rRNA interface [nucleotide binding]; other site
1117942000868	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1117942000869	50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157
1117942000870	L11 interface [polypeptide binding]; other site
1117942000871	putative EF-Tu interaction site [polypeptide binding]; other site
1117942000872	putative EF-G interaction site [polypeptide binding]; other site
1117942000873	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1117942000874	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
1117942000875	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942000876	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1117942000877	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942000878	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1117942000879	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1117942000880	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
1117942000881	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1117942000882	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1117942000883	ABC-ATPase subunit  interface; other site
1117942000884	dimer interface [polypeptide binding]; other site
1117942000885	putative PBP binding regions; other site
1117942000886	Ethylene insensitive 3; Region: EIN3; cl04813
1117942000887	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1117942000888	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1117942000889	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1117942000890	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1117942000891	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1117942000892	RPB1 interaction site [polypeptide binding]; other site
1117942000893	RPB10 interaction site [polypeptide binding]; other site
1117942000894	RPB11 interaction site [polypeptide binding]; other site
1117942000895	RPB3 interaction site [polypeptide binding]; other site
1117942000896	RPB12 interaction site [polypeptide binding]; other site
1117942000897	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1117942000898	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1117942000899	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1117942000900	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1117942000901	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1117942000902	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1117942000903	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1117942000904	G-loop; other site
1117942000905	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1117942000906	DNA binding site [nucleotide binding]
1117942000907	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1117942000908	Histidine kinase; Region: HisKA_3; pfam07730
1117942000909	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1117942000910	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117942000911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942000912	active site
1117942000913	phosphorylation site [posttranslational modification]
1117942000914	intermolecular recognition site; other site
1117942000915	dimerization interface [polypeptide binding]; other site
1117942000916	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117942000917	DNA binding residues [nucleotide binding]
1117942000918	dimerization interface [polypeptide binding]; other site
1117942000919	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1117942000920	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1117942000921	TIGR03943 family protein; Region: TIGR03943
1117942000922	Predicted permease; Region: DUF318; cl17795
1117942000923	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
1117942000924	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942000925	FeS/SAM binding site; other site
1117942000926	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
1117942000927	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1117942000928	effector binding site; other site
1117942000929	active site
1117942000930	Zn binding site [ion binding]; other site
1117942000931	glycine loop; other site
1117942000932	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1117942000933	S17 interaction site [polypeptide binding]; other site
1117942000934	S8 interaction site; other site
1117942000935	16S rRNA interaction site [nucleotide binding]; other site
1117942000936	streptomycin interaction site [chemical binding]; other site
1117942000937	23S rRNA interaction site [nucleotide binding]; other site
1117942000938	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1117942000939	30S ribosomal protein S7; Validated; Region: PRK05302
1117942000940	elongation factor G; Reviewed; Region: PRK00007
1117942000941	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1117942000942	G1 box; other site
1117942000943	putative GEF interaction site [polypeptide binding]; other site
1117942000944	GTP/Mg2+ binding site [chemical binding]; other site
1117942000945	Switch I region; other site
1117942000946	G2 box; other site
1117942000947	G3 box; other site
1117942000948	Switch II region; other site
1117942000949	G4 box; other site
1117942000950	G5 box; other site
1117942000951	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1117942000952	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1117942000953	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1117942000954	elongation factor Tu; Reviewed; Region: PRK00049
1117942000955	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1117942000956	G1 box; other site
1117942000957	GEF interaction site [polypeptide binding]; other site
1117942000958	GTP/Mg2+ binding site [chemical binding]; other site
1117942000959	Switch I region; other site
1117942000960	G2 box; other site
1117942000961	G3 box; other site
1117942000962	Switch II region; other site
1117942000963	G4 box; other site
1117942000964	G5 box; other site
1117942000965	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1117942000966	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1117942000967	Antibiotic Binding Site [chemical binding]; other site
1117942000968	Asp23 family; Region: Asp23; cl00574
1117942000969	Asp23 family; Region: Asp23; cl00574
1117942000970	Asp23 family; Region: Asp23; pfam03780
1117942000971	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1117942000972	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1117942000973	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1117942000974	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1117942000975	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1117942000976	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1117942000977	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1117942000978	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1117942000979	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1117942000980	putative translocon binding site; other site
1117942000981	protein-rRNA interface [nucleotide binding]; other site
1117942000982	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1117942000983	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1117942000984	G-X-X-G motif; other site
1117942000985	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1117942000986	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1117942000987	23S rRNA interface [nucleotide binding]; other site
1117942000988	5S rRNA interface [nucleotide binding]; other site
1117942000989	putative antibiotic binding site [chemical binding]; other site
1117942000990	L25 interface [polypeptide binding]; other site
1117942000991	L27 interface [polypeptide binding]; other site
1117942000992	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1117942000993	putative translocon interaction site; other site
1117942000994	23S rRNA interface [nucleotide binding]; other site
1117942000995	signal recognition particle (SRP54) interaction site; other site
1117942000996	L23 interface [polypeptide binding]; other site
1117942000997	trigger factor interaction site; other site
1117942000998	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1117942000999	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1117942001000	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1117942001001	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1117942001002	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942001003	Walker A/P-loop; other site
1117942001004	ATP binding site [chemical binding]; other site
1117942001005	Q-loop/lid; other site
1117942001006	ABC transporter signature motif; other site
1117942001007	Walker B; other site
1117942001008	D-loop; other site
1117942001009	H-loop/switch region; other site
1117942001010	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942001011	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942001012	Walker A/P-loop; other site
1117942001013	ATP binding site [chemical binding]; other site
1117942001014	Q-loop/lid; other site
1117942001015	ABC transporter signature motif; other site
1117942001016	Walker B; other site
1117942001017	D-loop; other site
1117942001018	H-loop/switch region; other site
1117942001019	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942001020	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1117942001021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001022	dimer interface [polypeptide binding]; other site
1117942001023	conserved gate region; other site
1117942001024	putative PBP binding loops; other site
1117942001025	ABC-ATPase subunit interface; other site
1117942001026	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942001027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001028	putative PBP binding loops; other site
1117942001029	dimer interface [polypeptide binding]; other site
1117942001030	ABC-ATPase subunit interface; other site
1117942001031	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1117942001032	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1117942001033	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1117942001034	RNA binding site [nucleotide binding]; other site
1117942001035	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1117942001036	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1117942001037	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1117942001038	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1117942001039	serine transporter; Region: stp; TIGR00814
1117942001040	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1117942001041	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1117942001042	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1117942001043	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1117942001044	active site
1117942001045	homotetramer interface [polypeptide binding]; other site
1117942001046	homodimer interface [polypeptide binding]; other site
1117942001047	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1117942001048	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1117942001049	active site
1117942001050	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1117942001051	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1117942001052	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1117942001053	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1117942001054	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1117942001055	5S rRNA interface [nucleotide binding]; other site
1117942001056	23S rRNA interface [nucleotide binding]; other site
1117942001057	L5 interface [polypeptide binding]; other site
1117942001058	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1117942001059	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1117942001060	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1117942001061	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1117942001062	23S rRNA binding site [nucleotide binding]; other site
1117942001063	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1117942001064	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1117942001065	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1117942001066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001067	dimer interface [polypeptide binding]; other site
1117942001068	conserved gate region; other site
1117942001069	putative PBP binding loops; other site
1117942001070	ABC-ATPase subunit interface; other site
1117942001071	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1117942001072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001073	dimer interface [polypeptide binding]; other site
1117942001074	conserved gate region; other site
1117942001075	putative PBP binding loops; other site
1117942001076	ABC-ATPase subunit interface; other site
1117942001077	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1117942001078	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1117942001079	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1117942001080	Walker A/P-loop; other site
1117942001081	ATP binding site [chemical binding]; other site
1117942001082	Q-loop/lid; other site
1117942001083	ABC transporter signature motif; other site
1117942001084	Walker B; other site
1117942001085	D-loop; other site
1117942001086	H-loop/switch region; other site
1117942001087	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1117942001088	SecY translocase; Region: SecY; pfam00344
1117942001089	adenylate kinase; Reviewed; Region: adk; PRK00279
1117942001090	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1117942001091	AMP-binding site [chemical binding]; other site
1117942001092	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1117942001093	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1117942001094	catalytic site [active]
1117942001095	BNR repeat-like domain; Region: BNR_2; pfam13088
1117942001096	Asp-box motif; other site
1117942001097	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1117942001098	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1117942001099	rRNA binding site [nucleotide binding]; other site
1117942001100	predicted 30S ribosome binding site; other site
1117942001101	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1117942001102	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1117942001103	30S ribosomal protein S11; Validated; Region: PRK05309
1117942001104	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1117942001105	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1117942001106	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117942001107	RNA binding surface [nucleotide binding]; other site
1117942001108	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1117942001109	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1117942001110	alphaNTD - beta interaction site [polypeptide binding]; other site
1117942001111	alphaNTD homodimer interface [polypeptide binding]; other site
1117942001112	alphaNTD - beta' interaction site [polypeptide binding]; other site
1117942001113	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1117942001114	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1117942001115	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1117942001116	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1117942001117	dimerization interface 3.5A [polypeptide binding]; other site
1117942001118	active site
1117942001119	Protein of unknown function (DUF690); Region: DUF690; cl04939
1117942001120	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
1117942001121	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1117942001122	active site
1117942001123	catalytic residues [active]
1117942001124	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1117942001125	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1117942001126	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1117942001127	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1117942001128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942001129	Walker A/P-loop; other site
1117942001130	ATP binding site [chemical binding]; other site
1117942001131	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1117942001132	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1117942001133	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1117942001134	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1117942001135	23S rRNA interface [nucleotide binding]; other site
1117942001136	L3 interface [polypeptide binding]; other site
1117942001137	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1117942001138	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1117942001139	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1117942001140	active site
1117942001141	substrate binding site [chemical binding]; other site
1117942001142	metal binding site [ion binding]; metal-binding site
1117942001143	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1117942001144	alanine racemase; Reviewed; Region: alr; PRK00053
1117942001145	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1117942001146	active site
1117942001147	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117942001148	dimer interface [polypeptide binding]; other site
1117942001149	substrate binding site [chemical binding]; other site
1117942001150	catalytic residues [active]
1117942001151	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1117942001152	Predicted permease [General function prediction only]; Region: COG2985
1117942001153	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1117942001154	TrkA-C domain; Region: TrkA_C; pfam02080
1117942001155	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1117942001156	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1117942001157	Glycoprotease family; Region: Peptidase_M22; pfam00814
1117942001158	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1117942001159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942001160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1117942001161	Coenzyme A binding pocket [chemical binding]; other site
1117942001162	UGMP family protein; Validated; Region: PRK09604
1117942001163	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1117942001164	oligomerisation interface [polypeptide binding]; other site
1117942001165	mobile loop; other site
1117942001166	roof hairpin; other site
1117942001167	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1117942001168	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1117942001169	ring oligomerisation interface [polypeptide binding]; other site
1117942001170	ATP/Mg binding site [chemical binding]; other site
1117942001171	stacking interactions; other site
1117942001172	hinge regions; other site
1117942001173	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1117942001174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942001175	inosine-5'-monophosphate dehydrogenase; Region: IMP_dehydrog; TIGR01302
1117942001176	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1117942001177	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1117942001178	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1117942001179	active site
1117942001180	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1117942001181	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1117942001182	phosphate binding site [ion binding]; other site
1117942001183	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1117942001184	GMP synthase; Reviewed; Region: guaA; PRK00074
1117942001185	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1117942001186	AMP/PPi binding site [chemical binding]; other site
1117942001187	candidate oxyanion hole; other site
1117942001188	catalytic triad [active]
1117942001189	potential glutamine specificity residues [chemical binding]; other site
1117942001190	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1117942001191	ATP Binding subdomain [chemical binding]; other site
1117942001192	Ligand Binding sites [chemical binding]; other site
1117942001193	Dimerization subdomain; other site
1117942001194	PspC domain; Region: PspC; cl00864
1117942001195	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1117942001196	PspC domain; Region: PspC; pfam04024
1117942001197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1117942001198	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1117942001199	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117942001200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942001201	active site
1117942001202	phosphorylation site [posttranslational modification]
1117942001203	intermolecular recognition site; other site
1117942001204	dimerization interface [polypeptide binding]; other site
1117942001205	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117942001206	dimerization interface [polypeptide binding]; other site
1117942001207	DNA binding residues [nucleotide binding]
1117942001208	AMIN domain; Region: AMIN; pfam11741
1117942001209	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
1117942001210	putative dimer interface [polypeptide binding]; other site
1117942001211	putative [2Fe-2S] cluster binding site [ion binding]; other site
1117942001212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001213	dimer interface [polypeptide binding]; other site
1117942001214	conserved gate region; other site
1117942001215	ABC-ATPase subunit interface; other site
1117942001216	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1117942001217	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1117942001218	Walker A/P-loop; other site
1117942001219	ATP binding site [chemical binding]; other site
1117942001220	Q-loop/lid; other site
1117942001221	ABC transporter signature motif; other site
1117942001222	Walker B; other site
1117942001223	D-loop; other site
1117942001224	H-loop/switch region; other site
1117942001225	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1117942001226	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1117942001227	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1117942001228	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1117942001229	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942001230	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1117942001231	intersubunit interface [polypeptide binding]; other site
1117942001232	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1117942001233	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1117942001234	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1117942001235	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942001236	ABC-ATPase subunit  interface; other site
1117942001237	dimer interface [polypeptide binding]; other site
1117942001238	putative PBP binding regions; other site
1117942001239	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1117942001240	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1117942001241	ABC-ATPase subunit  interface; other site
1117942001242	dimer interface [polypeptide binding]; other site
1117942001243	putative PBP binding regions; other site
1117942001244	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1117942001245	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1117942001246	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1117942001247	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1117942001248	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1117942001249	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1117942001250	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1117942001251	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1117942001252	homodimer interface [polypeptide binding]; other site
1117942001253	NADP binding site [chemical binding]; other site
1117942001254	substrate binding site [chemical binding]; other site
1117942001255	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1117942001256	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1117942001257	active site
1117942001258	Htaa; Region: HtaA; pfam04213
1117942001259	Htaa; Region: HtaA; pfam04213
1117942001260	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1117942001261	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942001262	intersubunit interface [polypeptide binding]; other site
1117942001263	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942001264	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942001265	ABC-ATPase subunit  interface; other site
1117942001266	dimer interface [polypeptide binding]; other site
1117942001267	putative PBP binding regions; other site
1117942001268	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1117942001269	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942001270	Walker A/P-loop; other site
1117942001271	ATP binding site [chemical binding]; other site
1117942001272	Q-loop/lid; other site
1117942001273	ABC transporter signature motif; other site
1117942001274	Walker B; other site
1117942001275	D-loop; other site
1117942001276	H-loop/switch region; other site
1117942001277	Htaa; Region: HtaA; pfam04213
1117942001278	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1117942001279	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1117942001280	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1117942001281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942001282	putative substrate translocation pore; other site
1117942001283	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1117942001284	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1117942001285	DNA binding residues [nucleotide binding]
1117942001286	dimer interface [polypeptide binding]; other site
1117942001287	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1117942001288	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1117942001289	putative catalytic site [active]
1117942001290	putative metal binding site [ion binding]; other site
1117942001291	putative phosphate binding site [ion binding]; other site
1117942001292	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1117942001293	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1117942001294	active site
1117942001295	HIGH motif; other site
1117942001296	dimer interface [polypeptide binding]; other site
1117942001297	KMSKS motif; other site
1117942001298	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1117942001299	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1117942001300	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1117942001301	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117942001302	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942001303	active site
1117942001304	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1117942001305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117942001306	non-specific DNA binding site [nucleotide binding]; other site
1117942001307	salt bridge; other site
1117942001308	sequence-specific DNA binding site [nucleotide binding]; other site
1117942001309	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1117942001310	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1117942001311	active site
1117942001312	substrate binding site [chemical binding]; other site
1117942001313	metal binding site [ion binding]; metal-binding site
1117942001314	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1117942001315	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1117942001316	metal binding site [ion binding]; metal-binding site
1117942001317	putative dimer interface [polypeptide binding]; other site
1117942001318	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1117942001319	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117942001320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117942001321	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117942001322	pyruvate carboxylase; Reviewed; Region: PRK12999
1117942001323	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117942001324	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117942001325	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1117942001326	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1117942001327	active site
1117942001328	catalytic residues [active]
1117942001329	metal binding site [ion binding]; metal-binding site
1117942001330	homodimer binding site [polypeptide binding]; other site
1117942001331	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117942001332	carboxyltransferase (CT) interaction site; other site
1117942001333	biotinylation site [posttranslational modification]; other site
1117942001334	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942001335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942001336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942001337	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1117942001338	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117942001339	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1117942001340	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1117942001341	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117942001342	carboxyltransferase (CT) interaction site; other site
1117942001343	biotinylation site [posttranslational modification]; other site
1117942001344	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1117942001345	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1117942001346	active site residue [active]
1117942001347	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1117942001348	active site residue [active]
1117942001349	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1117942001350	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1117942001351	Maf-like protein; Region: Maf; pfam02545
1117942001352	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1117942001353	active site
1117942001354	dimer interface [polypeptide binding]; other site
1117942001355	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1117942001356	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1117942001357	substrate binding site [chemical binding]; other site
1117942001358	ATP binding site [chemical binding]; other site
1117942001359	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1117942001360	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1117942001361	DNA binding site [nucleotide binding]
1117942001362	domain linker motif; other site
1117942001363	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
1117942001364	putative ligand binding site [chemical binding]; other site
1117942001365	dimerization interface [polypeptide binding]; other site
1117942001366	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1117942001367	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1117942001368	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1117942001369	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117942001370	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1117942001371	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1117942001372	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117942001373	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1117942001374	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1117942001375	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1117942001376	ATP-grasp domain; Region: ATP-grasp; pfam02222
1117942001377	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1117942001378	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1117942001379	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1117942001380	putative active site [active]
1117942001381	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1117942001382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001383	dimer interface [polypeptide binding]; other site
1117942001384	conserved gate region; other site
1117942001385	putative PBP binding loops; other site
1117942001386	ABC-ATPase subunit interface; other site
1117942001387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001388	dimer interface [polypeptide binding]; other site
1117942001389	conserved gate region; other site
1117942001390	putative PBP binding loops; other site
1117942001391	ABC-ATPase subunit interface; other site
1117942001392	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1117942001393	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1117942001394	TIGR03089 family protein; Region: TIGR03089
1117942001395	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1117942001396	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1117942001397	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1117942001398	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1117942001399	Probable Catalytic site; other site
1117942001400	metal-binding site
1117942001401	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1117942001402	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1117942001403	active site
1117942001404	Substrate binding site; other site
1117942001405	Mg++ binding site; other site
1117942001406	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117942001407	putative trimer interface [polypeptide binding]; other site
1117942001408	putative CoA binding site [chemical binding]; other site
1117942001409	Transcription factor WhiB; Region: Whib; pfam02467
1117942001410	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1117942001411	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1117942001412	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1117942001413	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1117942001414	active site
1117942001415	substrate binding site [chemical binding]; other site
1117942001416	metal binding site [ion binding]; metal-binding site
1117942001417	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1117942001418	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1117942001419	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1117942001420	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1117942001421	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
1117942001422	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1117942001423	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1117942001424	homotetramer interface [polypeptide binding]; other site
1117942001425	ligand binding site [chemical binding]; other site
1117942001426	catalytic site [active]
1117942001427	NAD binding site [chemical binding]; other site
1117942001428	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1117942001429	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1117942001430	TMP-binding site; other site
1117942001431	ATP-binding site [chemical binding]; other site
1117942001432	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117942001433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942001434	active site
1117942001435	phosphorylation site [posttranslational modification]
1117942001436	intermolecular recognition site; other site
1117942001437	dimerization interface [polypeptide binding]; other site
1117942001438	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117942001439	DNA binding site [nucleotide binding]
1117942001440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117942001441	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117942001442	dimerization interface [polypeptide binding]; other site
1117942001443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117942001444	dimer interface [polypeptide binding]; other site
1117942001445	phosphorylation site [posttranslational modification]
1117942001446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117942001447	ATP binding site [chemical binding]; other site
1117942001448	Mg2+ binding site [ion binding]; other site
1117942001449	G-X-G motif; other site
1117942001450	lipoprotein LpqB; Provisional; Region: PRK13616
1117942001451	Sporulation and spore germination; Region: Germane; pfam10646
1117942001452	comF family protein; Region: comF; TIGR00201
1117942001453	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942001454	active site
1117942001455	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1117942001456	30S subunit binding site; other site
1117942001457	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1117942001458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1117942001459	ATP binding site [chemical binding]; other site
1117942001460	putative Mg++ binding site [ion binding]; other site
1117942001461	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1117942001462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1117942001463	nucleotide binding region [chemical binding]; other site
1117942001464	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1117942001465	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1117942001466	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1117942001467	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1117942001468	FAD binding pocket [chemical binding]; other site
1117942001469	FAD binding motif [chemical binding]; other site
1117942001470	phosphate binding motif [ion binding]; other site
1117942001471	beta-alpha-beta structure motif; other site
1117942001472	NAD binding pocket [chemical binding]; other site
1117942001473	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1117942001474	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1117942001475	catalytic loop [active]
1117942001476	iron binding site [ion binding]; other site
1117942001477	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1117942001478	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1117942001479	putative di-iron ligands [ion binding]; other site
1117942001480	Predicted GTPases [General function prediction only]; Region: COG1162
1117942001481	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1117942001482	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1117942001483	GTP/Mg2+ binding site [chemical binding]; other site
1117942001484	G4 box; other site
1117942001485	G5 box; other site
1117942001486	G1 box; other site
1117942001487	Switch I region; other site
1117942001488	G2 box; other site
1117942001489	G3 box; other site
1117942001490	Switch II region; other site
1117942001491	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1117942001492	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1117942001493	hinge; other site
1117942001494	active site
1117942001495	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1117942001496	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1117942001497	putative deacylase active site [active]
1117942001498	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1117942001499	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942001500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942001501	DNA binding residues [nucleotide binding]
1117942001502	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
1117942001503	Transcription factor WhiB; Region: Whib; pfam02467
1117942001504	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1117942001505	active site
1117942001506	catalytic triad [active]
1117942001507	oxyanion hole [active]
1117942001508	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1117942001509	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117942001510	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1117942001511	ATP binding site [chemical binding]; other site
1117942001512	Mg++ binding site [ion binding]; other site
1117942001513	motif III; other site
1117942001514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942001515	nucleotide binding region [chemical binding]; other site
1117942001516	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1117942001517	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1117942001518	TIGR02569 family protein; Region: TIGR02569_actnb
1117942001519	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1117942001520	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1117942001521	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1117942001522	Part of AAA domain; Region: AAA_19; pfam13245
1117942001523	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1117942001524	Ion channel; Region: Ion_trans_2; pfam07885
1117942001525	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1117942001526	TrkA-N domain; Region: TrkA_N; pfam02254
1117942001527	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1117942001528	putative NADH binding site [chemical binding]; other site
1117942001529	putative active site [active]
1117942001530	nudix motif; other site
1117942001531	putative metal binding site [ion binding]; other site
1117942001532	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1117942001533	Part of AAA domain; Region: AAA_19; pfam13245
1117942001534	Family description; Region: UvrD_C_2; pfam13538
1117942001535	HRDC domain; Region: HRDC; pfam00570
1117942001536	Protein of unknown function DUF45; Region: DUF45; cl00636
1117942001537	putative hydrolase; Region: TIGR03624
1117942001538	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1117942001539	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117942001540	hypothetical protein; Validated; Region: PRK00068
1117942001541	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1117942001542	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1117942001543	sequence-specific DNA binding site [nucleotide binding]; other site
1117942001544	salt bridge; other site
1117942001545	Abi-like protein; Region: Abi_2; pfam07751
1117942001546	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1117942001547	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1117942001548	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
1117942001549	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1117942001550	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1117942001551	Predicted membrane protein [Function unknown]; Region: COG2311
1117942001552	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1117942001553	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942001554	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1117942001555	acyl-activating enzyme (AAE) consensus motif; other site
1117942001556	AMP binding site [chemical binding]; other site
1117942001557	active site
1117942001558	CoA binding site [chemical binding]; other site
1117942001559	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1117942001560	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1117942001561	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117942001562	putative trimer interface [polypeptide binding]; other site
1117942001563	putative CoA binding site [chemical binding]; other site
1117942001564	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117942001565	putative trimer interface [polypeptide binding]; other site
1117942001566	putative CoA binding site [chemical binding]; other site
1117942001567	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1117942001568	oxaloacetate decarboxylase; Provisional; Region: PRK12330
1117942001569	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1117942001570	active site
1117942001571	catalytic residues [active]
1117942001572	metal binding site [ion binding]; metal-binding site
1117942001573	homodimer binding site [polypeptide binding]; other site
1117942001574	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
1117942001575	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1117942001576	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117942001577	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117942001578	carboxyltransferase (CT) interaction site; other site
1117942001579	biotinylation site [posttranslational modification]; other site
1117942001580	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1117942001581	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1117942001582	active site
1117942001583	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1117942001584	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1117942001585	active site
1117942001586	topology modulation protein; Provisional; Region: PRK07261
1117942001587	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
1117942001588	active site
1117942001589	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
1117942001590	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1117942001591	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1117942001592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942001593	Walker A/P-loop; other site
1117942001594	ATP binding site [chemical binding]; other site
1117942001595	Q-loop/lid; other site
1117942001596	ABC transporter signature motif; other site
1117942001597	Walker B; other site
1117942001598	D-loop; other site
1117942001599	H-loop/switch region; other site
1117942001600	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1117942001601	FtsX-like permease family; Region: FtsX; pfam02687
1117942001602	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1117942001603	SmpB-tmRNA interface; other site
1117942001604	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1117942001605	active site clefts [active]
1117942001606	zinc binding site [ion binding]; other site
1117942001607	dimer interface [polypeptide binding]; other site
1117942001608	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1117942001609	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942001610	intersubunit interface [polypeptide binding]; other site
1117942001611	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942001612	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942001613	ABC-ATPase subunit  interface; other site
1117942001614	dimer interface [polypeptide binding]; other site
1117942001615	putative PBP binding regions; other site
1117942001616	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942001617	ABC-ATPase subunit  interface; other site
1117942001618	dimer interface [polypeptide binding]; other site
1117942001619	putative PBP binding regions; other site
1117942001620	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1117942001621	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942001622	Walker A/P-loop; other site
1117942001623	ATP binding site [chemical binding]; other site
1117942001624	Q-loop/lid; other site
1117942001625	ABC transporter signature motif; other site
1117942001626	Walker B; other site
1117942001627	D-loop; other site
1117942001628	H-loop/switch region; other site
1117942001629	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
1117942001630	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1117942001631	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1117942001632	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942001633	ATP binding site [chemical binding]; other site
1117942001634	putative Mg++ binding site [ion binding]; other site
1117942001635	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942001636	nucleotide binding region [chemical binding]; other site
1117942001637	ATP-binding site [chemical binding]; other site
1117942001638	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1117942001639	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1117942001640	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
1117942001641	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1117942001642	DNA-binding site [nucleotide binding]; DNA binding site
1117942001643	RNA-binding motif; other site
1117942001644	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1117942001645	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1117942001646	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1117942001647	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1117942001648	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1117942001649	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117942001650	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1117942001651	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1117942001652	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117942001653	catalytic residue [active]
1117942001654	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1117942001655	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1117942001656	dimer interface [polypeptide binding]; other site
1117942001657	active site
1117942001658	citrylCoA binding site [chemical binding]; other site
1117942001659	NADH binding [chemical binding]; other site
1117942001660	cationic pore residues; other site
1117942001661	oxalacetate/citrate binding site [chemical binding]; other site
1117942001662	coenzyme A binding site [chemical binding]; other site
1117942001663	catalytic triad [active]
1117942001664	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117942001665	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1117942001666	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1117942001667	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1117942001668	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1117942001669	E-class dimer interface [polypeptide binding]; other site
1117942001670	P-class dimer interface [polypeptide binding]; other site
1117942001671	active site
1117942001672	Cu2+ binding site [ion binding]; other site
1117942001673	Zn2+ binding site [ion binding]; other site
1117942001674	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1117942001675	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1117942001676	active site
1117942001677	catalytic tetrad [active]
1117942001678	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1117942001679	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117942001680	substrate binding site [chemical binding]; other site
1117942001681	oxyanion hole (OAH) forming residues; other site
1117942001682	trimer interface [polypeptide binding]; other site
1117942001683	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1117942001684	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1117942001685	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1117942001686	Na binding site [ion binding]; other site
1117942001687	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1117942001688	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1117942001689	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1117942001690	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1117942001691	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1117942001692	multidrug efflux protein NorA; Provisional; Region: PRK00187
1117942001693	cation binding site [ion binding]; other site
1117942001694	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1117942001695	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1117942001696	dimer interface [polypeptide binding]; other site
1117942001697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942001698	catalytic residue [active]
1117942001699	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1117942001700	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117942001701	catalytic residue [active]
1117942001702	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1117942001703	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1117942001704	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1117942001705	substrate binding pocket [chemical binding]; other site
1117942001706	active site
1117942001707	iron coordination sites [ion binding]; other site
1117942001708	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1117942001709	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1117942001710	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942001711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001712	dimer interface [polypeptide binding]; other site
1117942001713	conserved gate region; other site
1117942001714	putative PBP binding loops; other site
1117942001715	ABC-ATPase subunit interface; other site
1117942001716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1117942001717	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1117942001718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942001719	Walker A/P-loop; other site
1117942001720	ATP binding site [chemical binding]; other site
1117942001721	Q-loop/lid; other site
1117942001722	ABC transporter signature motif; other site
1117942001723	Walker B; other site
1117942001724	D-loop; other site
1117942001725	H-loop/switch region; other site
1117942001726	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942001727	Walker A/P-loop; other site
1117942001728	ATP binding site [chemical binding]; other site
1117942001729	Q-loop/lid; other site
1117942001730	ABC transporter signature motif; other site
1117942001731	Walker B; other site
1117942001732	D-loop; other site
1117942001733	H-loop/switch region; other site
1117942001734	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1117942001735	active site
1117942001736	SAM binding site [chemical binding]; other site
1117942001737	homodimer interface [polypeptide binding]; other site
1117942001738	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1117942001739	catalytic residues [active]
1117942001740	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1117942001741	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1117942001742	folate binding site [chemical binding]; other site
1117942001743	NADP+ binding site [chemical binding]; other site
1117942001744	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1117942001745	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1117942001746	dimerization interface [polypeptide binding]; other site
1117942001747	active site
1117942001748	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1117942001749	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1117942001750	active site
1117942001751	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942001752	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1117942001753	ATP binding site [chemical binding]; other site
1117942001754	putative Mg++ binding site [ion binding]; other site
1117942001755	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942001756	nucleotide binding region [chemical binding]; other site
1117942001757	ATP-binding site [chemical binding]; other site
1117942001758	DEAD/H associated; Region: DEAD_assoc; pfam08494
1117942001759	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1117942001760	active site
1117942001761	SUMO-1 interface [polypeptide binding]; other site
1117942001762	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1117942001763	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1117942001764	putative DNA binding site [nucleotide binding]; other site
1117942001765	catalytic residue [active]
1117942001766	putative H2TH interface [polypeptide binding]; other site
1117942001767	putative catalytic residues [active]
1117942001768	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1117942001769	hypothetical protein; Provisional; Region: PRK11770
1117942001770	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1117942001771	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1117942001772	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1117942001773	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1117942001774	active site
1117942001775	dimer interface [polypeptide binding]; other site
1117942001776	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1117942001777	dimer interface [polypeptide binding]; other site
1117942001778	active site
1117942001779	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117942001780	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1117942001781	tetramerization interface [polypeptide binding]; other site
1117942001782	NAD(P) binding site [chemical binding]; other site
1117942001783	catalytic residues [active]
1117942001784	hypothetical protein; Provisional; Region: PRK07857
1117942001785	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1117942001786	Part of AAA domain; Region: AAA_19; pfam13245
1117942001787	Family description; Region: UvrD_C_2; pfam13538
1117942001788	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1117942001789	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117942001790	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1117942001791	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1117942001792	active site
1117942001793	substrate binding site [chemical binding]; other site
1117942001794	cosubstrate binding site; other site
1117942001795	catalytic site [active]
1117942001796	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1117942001797	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1117942001798	purine monophosphate binding site [chemical binding]; other site
1117942001799	dimer interface [polypeptide binding]; other site
1117942001800	putative catalytic residues [active]
1117942001801	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1117942001802	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1117942001803	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1117942001804	Walker A/P-loop; other site
1117942001805	ATP binding site [chemical binding]; other site
1117942001806	Q-loop/lid; other site
1117942001807	ABC transporter signature motif; other site
1117942001808	Walker B; other site
1117942001809	D-loop; other site
1117942001810	H-loop/switch region; other site
1117942001811	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1117942001812	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117942001813	substrate binding pocket [chemical binding]; other site
1117942001814	membrane-bound complex binding site; other site
1117942001815	hinge residues; other site
1117942001816	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1117942001817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001818	dimer interface [polypeptide binding]; other site
1117942001819	conserved gate region; other site
1117942001820	putative PBP binding loops; other site
1117942001821	ABC-ATPase subunit interface; other site
1117942001822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942001823	dimer interface [polypeptide binding]; other site
1117942001824	conserved gate region; other site
1117942001825	putative PBP binding loops; other site
1117942001826	ABC-ATPase subunit interface; other site
1117942001827	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1117942001828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942001829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942001830	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
1117942001831	30S ribosomal protein S18; Provisional; Region: PRK13401
1117942001832	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1117942001833	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1117942001834	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1117942001835	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1117942001836	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1117942001837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117942001838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942001839	active site
1117942001840	phosphorylation site [posttranslational modification]
1117942001841	intermolecular recognition site; other site
1117942001842	dimerization interface [polypeptide binding]; other site
1117942001843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117942001844	DNA binding site [nucleotide binding]
1117942001845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117942001846	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117942001847	dimerization interface [polypeptide binding]; other site
1117942001848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117942001849	dimer interface [polypeptide binding]; other site
1117942001850	phosphorylation site [posttranslational modification]
1117942001851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117942001852	ATP binding site [chemical binding]; other site
1117942001853	Mg2+ binding site [ion binding]; other site
1117942001854	G-X-G motif; other site
1117942001855	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1117942001856	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1117942001857	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1117942001858	protein binding site [polypeptide binding]; other site
1117942001859	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1117942001860	MPT binding site; other site
1117942001861	trimer interface [polypeptide binding]; other site
1117942001862	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1117942001863	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1117942001864	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1117942001865	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
1117942001866	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1117942001867	active site
1117942001868	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1117942001869	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1117942001870	dimer interface [polypeptide binding]; other site
1117942001871	putative functional site; other site
1117942001872	putative MPT binding site; other site
1117942001873	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1117942001874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942001875	Coenzyme A binding pocket [chemical binding]; other site
1117942001876	Predicted membrane protein [Function unknown]; Region: COG2259
1117942001877	Predicted integral membrane protein [Function unknown]; Region: COG5660
1117942001878	Putative zinc-finger; Region: zf-HC2; pfam13490
1117942001879	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1117942001880	BCCT family transporter; Region: BCCT; pfam02028
1117942001881	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1117942001882	Predicted methyltransferases [General function prediction only]; Region: COG0313
1117942001883	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1117942001884	putative SAM binding site [chemical binding]; other site
1117942001885	putative homodimer interface [polypeptide binding]; other site
1117942001886	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1117942001887	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1117942001888	active site
1117942001889	HIGH motif; other site
1117942001890	KMSKS motif; other site
1117942001891	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1117942001892	tRNA binding surface [nucleotide binding]; other site
1117942001893	anticodon binding site; other site
1117942001894	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1117942001895	active site
1117942001896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1117942001897	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1117942001898	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1117942001899	G5 domain; Region: G5; pfam07501
1117942001900	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1117942001901	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1117942001902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942001903	S-adenosylmethionine binding site [chemical binding]; other site
1117942001904	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1117942001905	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1117942001906	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117942001907	ABC transporter; Region: ABC_tran_2; pfam12848
1117942001908	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117942001909	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1117942001910	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1117942001911	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1117942001912	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1117942001913	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1117942001914	substrate binding site [chemical binding]; other site
1117942001915	oxyanion hole (OAH) forming residues; other site
1117942001916	trimer interface [polypeptide binding]; other site
1117942001917	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1117942001918	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1117942001919	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1117942001920	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1117942001921	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1117942001922	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1117942001923	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1117942001924	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1117942001925	G1 box; other site
1117942001926	putative GEF interaction site [polypeptide binding]; other site
1117942001927	GTP/Mg2+ binding site [chemical binding]; other site
1117942001928	Switch I region; other site
1117942001929	G2 box; other site
1117942001930	G3 box; other site
1117942001931	Switch II region; other site
1117942001932	G4 box; other site
1117942001933	G5 box; other site
1117942001934	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1117942001935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942001936	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
1117942001937	NAD(P) binding site [chemical binding]; other site
1117942001938	active site
1117942001939	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1117942001940	putative active site [active]
1117942001941	catalytic residue [active]
1117942001942	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1117942001943	FMN binding site [chemical binding]; other site
1117942001944	substrate binding site [chemical binding]; other site
1117942001945	putative catalytic residue [active]
1117942001946	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1117942001947	putative active site [active]
1117942001948	catalytic residue [active]
1117942001949	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1117942001950	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1117942001951	5S rRNA interface [nucleotide binding]; other site
1117942001952	CTC domain interface [polypeptide binding]; other site
1117942001953	L16 interface [polypeptide binding]; other site
1117942001954	pullulanase, type I; Region: pulA_typeI; TIGR02104
1117942001955	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1117942001956	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1117942001957	Ca binding site [ion binding]; other site
1117942001958	active site
1117942001959	catalytic site [active]
1117942001960	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1117942001961	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1117942001962	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942001963	active site
1117942001964	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1117942001965	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1117942001966	Substrate binding site; other site
1117942001967	Mg++ binding site; other site
1117942001968	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1117942001969	active site
1117942001970	substrate binding site [chemical binding]; other site
1117942001971	CoA binding site [chemical binding]; other site
1117942001972	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1117942001973	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1117942001974	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1117942001975	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
1117942001976	gating phenylalanine in ion channel; other site
1117942001977	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942001978	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942001979	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1117942001980	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1117942001981	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942001982	ATP binding site [chemical binding]; other site
1117942001983	putative Mg++ binding site [ion binding]; other site
1117942001984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942001985	nucleotide binding region [chemical binding]; other site
1117942001986	ATP-binding site [chemical binding]; other site
1117942001987	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1117942001988	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1117942001989	Spore germination protein; Region: Spore_permease; cl17796
1117942001990	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1117942001991	homodimer interface [polypeptide binding]; other site
1117942001992	metal binding site [ion binding]; metal-binding site
1117942001993	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1117942001994	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1117942001995	enolase; Provisional; Region: eno; PRK00077
1117942001996	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1117942001997	dimer interface [polypeptide binding]; other site
1117942001998	metal binding site [ion binding]; metal-binding site
1117942001999	substrate binding pocket [chemical binding]; other site
1117942002000	Septum formation initiator; Region: DivIC; pfam04977
1117942002001	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1117942002002	Uncharacterized conserved protein [Function unknown]; Region: COG1507
1117942002003	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1117942002004	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1117942002005	Helix-turn-helix domain; Region: HTH_18; pfam12833
1117942002006	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1117942002007	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1117942002008	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1117942002009	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1117942002010	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1117942002011	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1117942002012	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1117942002013	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1117942002014	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1117942002015	catalytic residue [active]
1117942002016	putative FPP diphosphate  binding site; other site
1117942002017	putative FPP binding hydrophobic cleft; other site
1117942002018	dimer interface [polypeptide binding]; other site
1117942002019	putative IPP diphosphate binding site; other site
1117942002020	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
1117942002021	pantothenate kinase; Provisional; Region: PRK05439
1117942002022	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1117942002023	ATP-binding site [chemical binding]; other site
1117942002024	CoA-binding site [chemical binding]; other site
1117942002025	Mg2+-binding site [ion binding]; other site
1117942002026	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1117942002027	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1117942002028	dimer interface [polypeptide binding]; other site
1117942002029	active site
1117942002030	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1117942002031	folate binding site [chemical binding]; other site
1117942002032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942002033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002034	putative substrate translocation pore; other site
1117942002035	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942002036	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942002037	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1117942002038	dimerization interface [polypeptide binding]; other site
1117942002039	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1117942002040	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1117942002041	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1117942002042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942002043	Coenzyme A binding pocket [chemical binding]; other site
1117942002044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002045	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1117942002046	putative substrate translocation pore; other site
1117942002047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002048	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942002049	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1117942002050	Class II fumarases; Region: Fumarase_classII; cd01362
1117942002051	active site
1117942002052	tetramer interface [polypeptide binding]; other site
1117942002053	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1117942002054	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1117942002055	putative active site [active]
1117942002056	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1117942002057	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1117942002058	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1117942002059	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1117942002060	generic binding surface II; other site
1117942002061	generic binding surface I; other site
1117942002062	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1117942002063	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1117942002064	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1117942002065	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1117942002066	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1117942002067	GTP-binding protein YchF; Reviewed; Region: PRK09601
1117942002068	YchF GTPase; Region: YchF; cd01900
1117942002069	G1 box; other site
1117942002070	GTP/Mg2+ binding site [chemical binding]; other site
1117942002071	Switch I region; other site
1117942002072	G2 box; other site
1117942002073	Switch II region; other site
1117942002074	G3 box; other site
1117942002075	G4 box; other site
1117942002076	G5 box; other site
1117942002077	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1117942002078	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1117942002079	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1117942002080	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1117942002081	PhnA protein; Region: PhnA; pfam03831
1117942002082	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1117942002083	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117942002084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942002085	Walker A/P-loop; other site
1117942002086	ATP binding site [chemical binding]; other site
1117942002087	Q-loop/lid; other site
1117942002088	ABC transporter signature motif; other site
1117942002089	Walker B; other site
1117942002090	D-loop; other site
1117942002091	H-loop/switch region; other site
1117942002092	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1117942002093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117942002094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942002095	Walker A/P-loop; other site
1117942002096	ATP binding site [chemical binding]; other site
1117942002097	Q-loop/lid; other site
1117942002098	ABC transporter signature motif; other site
1117942002099	Walker B; other site
1117942002100	D-loop; other site
1117942002101	H-loop/switch region; other site
1117942002102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
1117942002103	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1117942002104	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1117942002105	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1117942002106	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1117942002107	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1117942002108	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1117942002109	Walker A/P-loop; other site
1117942002110	ATP binding site [chemical binding]; other site
1117942002111	Q-loop/lid; other site
1117942002112	ABC transporter signature motif; other site
1117942002113	Walker B; other site
1117942002114	D-loop; other site
1117942002115	H-loop/switch region; other site
1117942002116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942002117	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1117942002118	Walker A/P-loop; other site
1117942002119	ATP binding site [chemical binding]; other site
1117942002120	Q-loop/lid; other site
1117942002121	ABC transporter signature motif; other site
1117942002122	Walker B; other site
1117942002123	D-loop; other site
1117942002124	H-loop/switch region; other site
1117942002125	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1117942002126	hypothetical protein; Provisional; Region: PRK06547
1117942002127	Predicted kinase [General function prediction only]; Region: COG0645
1117942002128	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1117942002129	nudix motif; other site
1117942002130	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1117942002131	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1117942002132	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942002133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942002134	dimer interface [polypeptide binding]; other site
1117942002135	conserved gate region; other site
1117942002136	ABC-ATPase subunit interface; other site
1117942002137	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1117942002138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942002139	dimer interface [polypeptide binding]; other site
1117942002140	conserved gate region; other site
1117942002141	putative PBP binding loops; other site
1117942002142	ABC-ATPase subunit interface; other site
1117942002143	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1117942002144	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942002145	Walker A/P-loop; other site
1117942002146	ATP binding site [chemical binding]; other site
1117942002147	Q-loop/lid; other site
1117942002148	ABC transporter signature motif; other site
1117942002149	Walker B; other site
1117942002150	D-loop; other site
1117942002151	H-loop/switch region; other site
1117942002152	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942002153	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942002154	Walker A/P-loop; other site
1117942002155	ATP binding site [chemical binding]; other site
1117942002156	Q-loop/lid; other site
1117942002157	ABC transporter signature motif; other site
1117942002158	Walker B; other site
1117942002159	D-loop; other site
1117942002160	H-loop/switch region; other site
1117942002161	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942002162	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1117942002163	cleavage site
1117942002164	active site
1117942002165	substrate binding sites [chemical binding]; other site
1117942002166	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1117942002167	ArsC family; Region: ArsC; pfam03960
1117942002168	catalytic residues [active]
1117942002169	Protein of unknown function (DUF402); Region: DUF402; cl00979
1117942002170	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1117942002171	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1117942002172	G1 box; other site
1117942002173	GTP/Mg2+ binding site [chemical binding]; other site
1117942002174	G2 box; other site
1117942002175	Switch I region; other site
1117942002176	G3 box; other site
1117942002177	Switch II region; other site
1117942002178	G4 box; other site
1117942002179	G5 box; other site
1117942002180	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1117942002181	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1117942002182	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1117942002183	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1117942002184	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1117942002185	Ferredoxin [Energy production and conversion]; Region: COG1146
1117942002186	4Fe-4S binding domain; Region: Fer4; pfam00037
1117942002187	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1117942002188	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117942002189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942002190	homodimer interface [polypeptide binding]; other site
1117942002191	catalytic residue [active]
1117942002192	Predicted membrane protein [Function unknown]; Region: COG2246
1117942002193	GtrA-like protein; Region: GtrA; pfam04138
1117942002194	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1117942002195	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1117942002196	active site
1117942002197	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1117942002198	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1117942002199	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1117942002200	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1117942002201	putative trimer interface [polypeptide binding]; other site
1117942002202	putative CoA binding site [chemical binding]; other site
1117942002203	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1117942002204	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1117942002205	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1117942002206	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117942002207	putative trimer interface [polypeptide binding]; other site
1117942002208	putative CoA binding site [chemical binding]; other site
1117942002209	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1117942002210	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1117942002211	metal binding site [ion binding]; metal-binding site
1117942002212	putative dimer interface [polypeptide binding]; other site
1117942002213	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1117942002214	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1117942002215	dihydropteroate synthase; Region: DHPS; TIGR01496
1117942002216	substrate binding pocket [chemical binding]; other site
1117942002217	dimer interface [polypeptide binding]; other site
1117942002218	inhibitor binding site; inhibition site
1117942002219	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1117942002220	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1117942002221	Ligand binding site; other site
1117942002222	Putative Catalytic site; other site
1117942002223	DXD motif; other site
1117942002224	DivIVA domain; Region: DivI1A_domain; TIGR03544
1117942002225	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1117942002226	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1117942002227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002228	S-adenosylmethionine binding site [chemical binding]; other site
1117942002229	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1117942002230	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1117942002231	active site
1117942002232	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1117942002233	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1117942002234	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1117942002235	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117942002236	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1117942002237	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1117942002238	ligand binding site; other site
1117942002239	oligomer interface; other site
1117942002240	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1117942002241	dimer interface [polypeptide binding]; other site
1117942002242	N-terminal domain interface [polypeptide binding]; other site
1117942002243	sulfate 1 binding site; other site
1117942002244	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1117942002245	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1117942002246	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942002247	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942002248	DNA binding residues [nucleotide binding]
1117942002249	sec-independent translocase; Provisional; Region: tatB; PRK00182
1117942002250	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1117942002251	Domain of unknown function DUF59; Region: DUF59; pfam01883
1117942002252	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1117942002253	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1117942002254	Predicted membrane protein [Function unknown]; Region: COG4420
1117942002255	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1117942002256	MgtE intracellular N domain; Region: MgtE_N; smart00924
1117942002257	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1117942002258	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1117942002259	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1117942002260	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1117942002261	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1117942002262	TPP-binding site [chemical binding]; other site
1117942002263	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1117942002264	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1117942002265	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117942002266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942002267	Walker A/P-loop; other site
1117942002268	ATP binding site [chemical binding]; other site
1117942002269	Q-loop/lid; other site
1117942002270	ABC transporter signature motif; other site
1117942002271	Walker B; other site
1117942002272	D-loop; other site
1117942002273	H-loop/switch region; other site
1117942002274	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1117942002275	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117942002276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942002277	Walker A/P-loop; other site
1117942002278	ATP binding site [chemical binding]; other site
1117942002279	Q-loop/lid; other site
1117942002280	ABC transporter signature motif; other site
1117942002281	Walker B; other site
1117942002282	D-loop; other site
1117942002283	H-loop/switch region; other site
1117942002284	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1117942002285	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1117942002286	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1117942002287	shikimate binding site; other site
1117942002288	NAD(P) binding site [chemical binding]; other site
1117942002289	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1117942002290	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1117942002291	substrate binding pocket [chemical binding]; other site
1117942002292	catalytic triad [active]
1117942002293	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1117942002294	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1117942002295	active site
1117942002296	catalytic residues [active]
1117942002297	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1117942002298	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
1117942002299	Na binding site [ion binding]; other site
1117942002300	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1117942002301	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1117942002302	nucleotide binding site/active site [active]
1117942002303	HIT family signature motif; other site
1117942002304	catalytic residue [active]
1117942002305	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1117942002306	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1117942002307	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1117942002308	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1117942002309	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1117942002310	ATP binding site [chemical binding]; other site
1117942002311	Mg++ binding site [ion binding]; other site
1117942002312	motif III; other site
1117942002313	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942002314	nucleotide binding region [chemical binding]; other site
1117942002315	ATP-binding site [chemical binding]; other site
1117942002316	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1117942002317	putative RNA binding site [nucleotide binding]; other site
1117942002318	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1117942002319	dimer interface [polypeptide binding]; other site
1117942002320	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117942002321	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1117942002322	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1117942002323	Na binding site [ion binding]; other site
1117942002324	SNF2 Helicase protein; Region: DUF3670; pfam12419
1117942002325	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1117942002326	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942002327	ATP binding site [chemical binding]; other site
1117942002328	putative Mg++ binding site [ion binding]; other site
1117942002329	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942002330	nucleotide binding region [chemical binding]; other site
1117942002331	ATP-binding site [chemical binding]; other site
1117942002332	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1117942002333	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1117942002334	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1117942002335	active site
1117942002336	metal binding site [ion binding]; metal-binding site
1117942002337	DNA binding site [nucleotide binding]
1117942002338	AAA ATPase domain; Region: AAA_15; pfam13175
1117942002339	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1117942002340	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1117942002341	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1117942002342	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1117942002343	MarR family; Region: MarR_2; pfam12802
1117942002344	PspC domain; Region: PspC; pfam04024
1117942002345	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1117942002346	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1117942002347	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1117942002348	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1117942002349	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1117942002350	Cysteine-rich domain; Region: CCG; pfam02754
1117942002351	Cysteine-rich domain; Region: CCG; pfam02754
1117942002352	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1117942002353	L-lactate permease; Region: Lactate_perm; cl00701
1117942002354	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1117942002355	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1117942002356	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1117942002357	active site
1117942002358	HIGH motif; other site
1117942002359	KMSK motif region; other site
1117942002360	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1117942002361	tRNA binding surface [nucleotide binding]; other site
1117942002362	anticodon binding site; other site
1117942002363	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1117942002364	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1117942002365	active site
1117942002366	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1117942002367	substrate binding site [chemical binding]; other site
1117942002368	catalytic residues [active]
1117942002369	dimer interface [polypeptide binding]; other site
1117942002370	homoserine dehydrogenase; Provisional; Region: PRK06349
1117942002371	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1117942002372	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1117942002373	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1117942002374	homoserine kinase; Provisional; Region: PRK01212
1117942002375	Predicted transcriptional regulator [Transcription]; Region: COG2345
1117942002376	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
1117942002377	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
1117942002378	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942002379	acyl-activating enzyme (AAE) consensus motif; other site
1117942002380	AMP binding site [chemical binding]; other site
1117942002381	active site
1117942002382	CoA binding site [chemical binding]; other site
1117942002383	transcription termination factor Rho; Provisional; Region: PRK12678
1117942002384	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1117942002385	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117942002386	RNA binding site [nucleotide binding]; other site
1117942002387	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1117942002388	multimer interface [polypeptide binding]; other site
1117942002389	Walker A motif; other site
1117942002390	ATP binding site [chemical binding]; other site
1117942002391	Walker B motif; other site
1117942002392	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1117942002393	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1117942002394	RF-1 domain; Region: RF-1; pfam00472
1117942002395	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1117942002396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002397	S-adenosylmethionine binding site [chemical binding]; other site
1117942002398	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1117942002399	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1117942002400	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1117942002401	Mg++ binding site [ion binding]; other site
1117942002402	putative catalytic motif [active]
1117942002403	substrate binding site [chemical binding]; other site
1117942002404	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1117942002405	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1117942002406	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
1117942002407	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1117942002408	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1117942002409	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1117942002410	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1117942002411	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1117942002412	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1117942002413	beta subunit interaction interface [polypeptide binding]; other site
1117942002414	Walker A motif; other site
1117942002415	ATP binding site [chemical binding]; other site
1117942002416	Walker B motif; other site
1117942002417	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1117942002418	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1117942002419	core domain interface [polypeptide binding]; other site
1117942002420	delta subunit interface [polypeptide binding]; other site
1117942002421	epsilon subunit interface [polypeptide binding]; other site
1117942002422	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1117942002423	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1117942002424	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1117942002425	alpha subunit interaction interface [polypeptide binding]; other site
1117942002426	Walker A motif; other site
1117942002427	ATP binding site [chemical binding]; other site
1117942002428	Walker B motif; other site
1117942002429	inhibitor binding site; inhibition site
1117942002430	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1117942002431	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1117942002432	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1117942002433	gamma subunit interface [polypeptide binding]; other site
1117942002434	epsilon subunit interface [polypeptide binding]; other site
1117942002435	LBP interface [polypeptide binding]; other site
1117942002436	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1117942002437	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1117942002438	hypothetical protein; Provisional; Region: PRK03298
1117942002439	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1117942002440	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117942002441	dimer interface [polypeptide binding]; other site
1117942002442	substrate binding site [chemical binding]; other site
1117942002443	metal binding site [ion binding]; metal-binding site
1117942002444	Domain of unknown function DUF77; Region: DUF77; pfam01910
1117942002445	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1117942002446	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1117942002447	glycogen branching enzyme; Provisional; Region: PRK05402
1117942002448	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1117942002449	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1117942002450	active site
1117942002451	catalytic site [active]
1117942002452	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1117942002453	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1117942002454	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1117942002455	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1117942002456	active site
1117942002457	catalytic site [active]
1117942002458	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117942002459	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942002460	Walker A/P-loop; other site
1117942002461	ATP binding site [chemical binding]; other site
1117942002462	ABC transporter signature motif; other site
1117942002463	Walker B; other site
1117942002464	D-loop; other site
1117942002465	H-loop/switch region; other site
1117942002466	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1117942002467	Ligand binding site [chemical binding]; other site
1117942002468	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1117942002469	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1117942002470	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1117942002471	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1117942002472	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1117942002473	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1117942002474	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117942002475	catalytic residue [active]
1117942002476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002477	S-adenosylmethionine binding site [chemical binding]; other site
1117942002478	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1117942002479	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1117942002480	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1117942002481	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1117942002482	active site
1117942002483	catalytic site [active]
1117942002484	substrate binding site [chemical binding]; other site
1117942002485	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1117942002486	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1117942002487	nucleotide binding pocket [chemical binding]; other site
1117942002488	K-X-D-G motif; other site
1117942002489	catalytic site [active]
1117942002490	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1117942002491	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1117942002492	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1117942002493	Dimer interface [polypeptide binding]; other site
1117942002494	BRCT sequence motif; other site
1117942002495	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1117942002496	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1117942002497	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1117942002498	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1117942002499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1117942002500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002501	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942002502	putative substrate translocation pore; other site
1117942002503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002504	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942002505	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942002506	ABC-ATPase subunit  interface; other site
1117942002507	dimer interface [polypeptide binding]; other site
1117942002508	putative PBP binding regions; other site
1117942002509	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942002510	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
1117942002511	Walker A/P-loop; other site
1117942002512	ATP binding site [chemical binding]; other site
1117942002513	Q-loop/lid; other site
1117942002514	ABC transporter signature motif; other site
1117942002515	Walker B; other site
1117942002516	D-loop; other site
1117942002517	H-loop/switch region; other site
1117942002518	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1117942002519	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1117942002520	putative ligand binding residues [chemical binding]; other site
1117942002521	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1117942002522	phosphofructokinase; Region: PFK_mixed; TIGR02483
1117942002523	active site
1117942002524	ADP/pyrophosphate binding site [chemical binding]; other site
1117942002525	dimerization interface [polypeptide binding]; other site
1117942002526	allosteric effector site; other site
1117942002527	fructose-1,6-bisphosphate binding site; other site
1117942002528	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1117942002529	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1117942002530	GatB domain; Region: GatB_Yqey; smart00845
1117942002531	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1117942002532	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1117942002533	active site
1117942002534	catalytic tetrad [active]
1117942002535	Lysine efflux permease [General function prediction only]; Region: COG1279
1117942002536	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1117942002537	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117942002538	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1117942002539	dimerization interface [polypeptide binding]; other site
1117942002540	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1117942002541	Predicted membrane protein [Function unknown]; Region: COG2259
1117942002542	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1117942002543	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1117942002544	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117942002545	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117942002546	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1117942002547	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1117942002548	putative valine binding site [chemical binding]; other site
1117942002549	dimer interface [polypeptide binding]; other site
1117942002550	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1117942002551	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1117942002552	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1117942002553	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1117942002554	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1117942002555	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1117942002556	Protein of unknown function DUF262; Region: DUF262; pfam03235
1117942002557	Uncharacterized conserved protein [Function unknown]; Region: COG3472
1117942002558	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1117942002559	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1117942002560	ligand binding site [chemical binding]; other site
1117942002561	NAD binding site [chemical binding]; other site
1117942002562	dimerization interface [polypeptide binding]; other site
1117942002563	catalytic site [active]
1117942002564	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1117942002565	putative L-serine binding site [chemical binding]; other site
1117942002566	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1117942002567	tartrate dehydrogenase; Region: TTC; TIGR02089
1117942002568	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1117942002569	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1117942002570	ligand binding site [chemical binding]; other site
1117942002571	flexible hinge region; other site
1117942002572	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
1117942002573	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1117942002574	metal binding triad; other site
1117942002575	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1117942002576	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1117942002577	active site
1117942002578	catalytic site [active]
1117942002579	substrate binding site [chemical binding]; other site
1117942002580	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1117942002581	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1117942002582	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1117942002583	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1117942002584	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1117942002585	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1117942002586	active site
1117942002587	HIGH motif; other site
1117942002588	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1117942002589	active site
1117942002590	KMSKS motif; other site
1117942002591	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1117942002592	Cutinase; Region: Cutinase; pfam01083
1117942002593	biotin synthase; Region: bioB; TIGR00433
1117942002594	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942002595	FeS/SAM binding site; other site
1117942002596	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1117942002597	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1117942002598	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117942002599	Zn2+ binding site [ion binding]; other site
1117942002600	Mg2+ binding site [ion binding]; other site
1117942002601	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1117942002602	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1117942002603	Bacterial transcriptional regulator; Region: IclR; pfam01614
1117942002604	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1117942002605	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1117942002606	substrate binding site [chemical binding]; other site
1117942002607	ligand binding site [chemical binding]; other site
1117942002608	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1117942002609	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1117942002610	substrate binding site [chemical binding]; other site
1117942002611	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1117942002612	active site
1117942002613	Ap6A binding site [chemical binding]; other site
1117942002614	nudix motif; other site
1117942002615	metal binding site [ion binding]; metal-binding site
1117942002616	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942002617	catalytic core [active]
1117942002618	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1117942002619	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1117942002620	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1117942002621	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1117942002622	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1117942002623	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117942002624	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1117942002625	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1117942002626	thiamine monophosphate kinase; Provisional; Region: PRK05731
1117942002627	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1117942002628	ATP binding site [chemical binding]; other site
1117942002629	dimerization interface [polypeptide binding]; other site
1117942002630	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1117942002631	ligand binding site [chemical binding]; other site
1117942002632	active site
1117942002633	UGI interface [polypeptide binding]; other site
1117942002634	catalytic site [active]
1117942002635	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1117942002636	DAK2 domain; Region: Dak2; pfam02734
1117942002637	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1117942002638	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1117942002639	generic binding surface II; other site
1117942002640	ssDNA binding site; other site
1117942002641	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942002642	ATP binding site [chemical binding]; other site
1117942002643	putative Mg++ binding site [ion binding]; other site
1117942002644	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942002645	nucleotide binding region [chemical binding]; other site
1117942002646	ATP-binding site [chemical binding]; other site
1117942002647	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1117942002648	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1117942002649	carboxyltransferase (CT) interaction site; other site
1117942002650	biotinylation site [posttranslational modification]; other site
1117942002651	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1117942002652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002653	S-adenosylmethionine binding site [chemical binding]; other site
1117942002654	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1117942002655	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1117942002656	active site
1117942002657	(T/H)XGH motif; other site
1117942002658	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1117942002659	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1117942002660	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1117942002661	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1117942002662	Walker A/P-loop; other site
1117942002663	ATP binding site [chemical binding]; other site
1117942002664	Q-loop/lid; other site
1117942002665	ABC transporter signature motif; other site
1117942002666	Walker B; other site
1117942002667	D-loop; other site
1117942002668	H-loop/switch region; other site
1117942002669	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1117942002670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942002671	dimer interface [polypeptide binding]; other site
1117942002672	conserved gate region; other site
1117942002673	putative PBP binding loops; other site
1117942002674	ABC-ATPase subunit interface; other site
1117942002675	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117942002676	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117942002677	substrate binding pocket [chemical binding]; other site
1117942002678	membrane-bound complex binding site; other site
1117942002679	hinge residues; other site
1117942002680	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1117942002681	DNA polymerase I; Provisional; Region: PRK05755
1117942002682	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1117942002683	active site
1117942002684	metal binding site 1 [ion binding]; metal-binding site
1117942002685	putative 5' ssDNA interaction site; other site
1117942002686	metal binding site 3; metal-binding site
1117942002687	metal binding site 2 [ion binding]; metal-binding site
1117942002688	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1117942002689	putative DNA binding site [nucleotide binding]; other site
1117942002690	putative metal binding site [ion binding]; other site
1117942002691	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1117942002692	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1117942002693	active site
1117942002694	DNA binding site [nucleotide binding]
1117942002695	catalytic site [active]
1117942002696	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1117942002697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002698	S-adenosylmethionine binding site [chemical binding]; other site
1117942002699	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1117942002700	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1117942002701	RNA binding site [nucleotide binding]; other site
1117942002702	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1117942002703	RNA binding site [nucleotide binding]; other site
1117942002704	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117942002705	RNA binding site [nucleotide binding]; other site
1117942002706	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1117942002707	RNA binding site [nucleotide binding]; other site
1117942002708	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1117942002709	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1117942002710	active site turn [active]
1117942002711	phosphorylation site [posttranslational modification]
1117942002712	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1117942002713	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1117942002714	HPr interaction site; other site
1117942002715	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1117942002716	active site
1117942002717	phosphorylation site [posttranslational modification]
1117942002718	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1117942002719	ATP-binding [chemical binding]; other site
1117942002720	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1117942002721	CoA-binding site [chemical binding]; other site
1117942002722	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1117942002723	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942002724	FeS/SAM binding site; other site
1117942002725	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1117942002726	excinuclease ABC subunit B; Provisional; Region: PRK05298
1117942002727	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942002728	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942002729	nucleotide binding region [chemical binding]; other site
1117942002730	ATP-binding site [chemical binding]; other site
1117942002731	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1117942002732	UvrB/uvrC motif; Region: UVR; pfam02151
1117942002733	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117942002734	Ligand Binding Site [chemical binding]; other site
1117942002735	Predicted membrane protein [Function unknown]; Region: COG2259
1117942002736	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117942002737	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1117942002738	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1117942002739	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1117942002740	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1117942002741	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1117942002742	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1117942002743	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1117942002744	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1117942002745	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1117942002746	23S rRNA binding site [nucleotide binding]; other site
1117942002747	L21 binding site [polypeptide binding]; other site
1117942002748	L13 binding site [polypeptide binding]; other site
1117942002749	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1117942002750	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1117942002751	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117942002752	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1117942002753	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1117942002754	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1117942002755	dimer interface [polypeptide binding]; other site
1117942002756	motif 1; other site
1117942002757	active site
1117942002758	motif 2; other site
1117942002759	motif 3; other site
1117942002760	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1117942002761	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1117942002762	putative tRNA-binding site [nucleotide binding]; other site
1117942002763	B3/4 domain; Region: B3_4; pfam03483
1117942002764	tRNA synthetase B5 domain; Region: B5; smart00874
1117942002765	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1117942002766	dimer interface [polypeptide binding]; other site
1117942002767	motif 1; other site
1117942002768	motif 3; other site
1117942002769	motif 2; other site
1117942002770	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1117942002771	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1117942002772	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1117942002773	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1117942002774	heterotetramer interface [polypeptide binding]; other site
1117942002775	active site pocket [active]
1117942002776	cleavage site
1117942002777	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1117942002778	feedback inhibition sensing region; other site
1117942002779	homohexameric interface [polypeptide binding]; other site
1117942002780	nucleotide binding site [chemical binding]; other site
1117942002781	N-acetyl-L-glutamate binding site [chemical binding]; other site
1117942002782	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1117942002783	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117942002784	inhibitor-cofactor binding pocket; inhibition site
1117942002785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942002786	catalytic residue [active]
1117942002787	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1117942002788	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1117942002789	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1117942002790	arginine repressor; Provisional; Region: PRK03341
1117942002791	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1117942002792	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1117942002793	argininosuccinate synthase; Provisional; Region: PRK13820
1117942002794	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1117942002795	ANP binding site [chemical binding]; other site
1117942002796	Substrate Binding Site II [chemical binding]; other site
1117942002797	Substrate Binding Site I [chemical binding]; other site
1117942002798	argininosuccinate lyase; Provisional; Region: PRK00855
1117942002799	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1117942002800	active sites [active]
1117942002801	tetramer interface [polypeptide binding]; other site
1117942002802	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1117942002803	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1117942002804	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1117942002805	active site
1117942002806	HIGH motif; other site
1117942002807	dimer interface [polypeptide binding]; other site
1117942002808	KMSKS motif; other site
1117942002809	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117942002810	RNA binding surface [nucleotide binding]; other site
1117942002811	transcription termination factor Rho; Provisional; Region: PRK12678
1117942002812	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1117942002813	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942002814	active site
1117942002815	motif I; other site
1117942002816	motif II; other site
1117942002817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942002818	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1117942002819	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117942002820	RNA binding surface [nucleotide binding]; other site
1117942002821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002822	S-adenosylmethionine binding site [chemical binding]; other site
1117942002823	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1117942002824	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1117942002825	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1117942002826	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1117942002827	Walker A/P-loop; other site
1117942002828	ATP binding site [chemical binding]; other site
1117942002829	Q-loop/lid; other site
1117942002830	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1117942002831	ABC transporter signature motif; other site
1117942002832	Walker B; other site
1117942002833	D-loop; other site
1117942002834	H-loop/switch region; other site
1117942002835	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1117942002836	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
1117942002837	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1117942002838	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1117942002839	dimer interface [polypeptide binding]; other site
1117942002840	ADP-ribose binding site [chemical binding]; other site
1117942002841	active site
1117942002842	nudix motif; other site
1117942002843	metal binding site [ion binding]; metal-binding site
1117942002844	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1117942002845	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1117942002846	active site
1117942002847	Int/Topo IB signature motif; other site
1117942002848	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1117942002849	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1117942002850	P-loop; other site
1117942002851	Magnesium ion binding site [ion binding]; other site
1117942002852	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1117942002853	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1117942002854	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1117942002855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002856	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1117942002857	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
1117942002858	inhibitor-cofactor binding pocket; inhibition site
1117942002859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942002860	catalytic residue [active]
1117942002861	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1117942002862	AAA domain; Region: AAA_26; pfam13500
1117942002863	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1117942002864	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1117942002865	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117942002866	RNA binding surface [nucleotide binding]; other site
1117942002867	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1117942002868	active site
1117942002869	cytidylate kinase; Provisional; Region: cmk; PRK00023
1117942002870	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1117942002871	CMP-binding site; other site
1117942002872	The sites determining sugar specificity; other site
1117942002873	GTP-binding protein Der; Reviewed; Region: PRK03003
1117942002874	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1117942002875	G1 box; other site
1117942002876	GTP/Mg2+ binding site [chemical binding]; other site
1117942002877	Switch I region; other site
1117942002878	G2 box; other site
1117942002879	Switch II region; other site
1117942002880	G3 box; other site
1117942002881	G4 box; other site
1117942002882	G5 box; other site
1117942002883	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1117942002884	G1 box; other site
1117942002885	GTP/Mg2+ binding site [chemical binding]; other site
1117942002886	Switch I region; other site
1117942002887	G2 box; other site
1117942002888	G3 box; other site
1117942002889	Switch II region; other site
1117942002890	G4 box; other site
1117942002891	G5 box; other site
1117942002892	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1117942002893	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1117942002894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002895	S-adenosylmethionine binding site [chemical binding]; other site
1117942002896	Predicted esterase [General function prediction only]; Region: COG0627
1117942002897	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1117942002898	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1117942002899	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942002900	intersubunit interface [polypeptide binding]; other site
1117942002901	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942002902	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942002903	dimer interface [polypeptide binding]; other site
1117942002904	ABC-ATPase subunit  interface; other site
1117942002905	putative PBP binding regions; other site
1117942002906	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942002907	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942002908	ABC-ATPase subunit  interface; other site
1117942002909	dimer interface [polypeptide binding]; other site
1117942002910	putative PBP binding regions; other site
1117942002911	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117942002912	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942002913	Walker A/P-loop; other site
1117942002914	ATP binding site [chemical binding]; other site
1117942002915	Q-loop/lid; other site
1117942002916	ABC transporter signature motif; other site
1117942002917	Walker B; other site
1117942002918	D-loop; other site
1117942002919	H-loop/switch region; other site
1117942002920	IucA / IucC family; Region: IucA_IucC; pfam04183
1117942002921	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1117942002922	IucA / IucC family; Region: IucA_IucC; pfam04183
1117942002923	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1117942002924	H+ Antiporter protein; Region: 2A0121; TIGR00900
1117942002925	hypothetical protein; Provisional; Region: PRK01842
1117942002926	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117942002927	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117942002928	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1117942002929	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1117942002930	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1117942002931	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942002932	nucleotide binding region [chemical binding]; other site
1117942002933	ATP-binding site [chemical binding]; other site
1117942002934	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1117942002935	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1117942002936	phosphopeptide binding site; other site
1117942002937	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1117942002938	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1117942002939	DNA binding residues [nucleotide binding]
1117942002940	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1117942002941	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1117942002942	DNA binding residues [nucleotide binding]
1117942002943	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1117942002944	putative dimer interface [polypeptide binding]; other site
1117942002945	Domain of unknown function DUF21; Region: DUF21; pfam01595
1117942002946	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1117942002947	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1117942002948	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1117942002949	Domain of unknown function DUF21; Region: DUF21; pfam01595
1117942002950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1117942002951	Transporter associated domain; Region: CorC_HlyC; smart01091
1117942002952	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1117942002953	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1117942002954	ATP binding site [chemical binding]; other site
1117942002955	putative Mg++ binding site [ion binding]; other site
1117942002956	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942002957	nucleotide binding region [chemical binding]; other site
1117942002958	ATP-binding site [chemical binding]; other site
1117942002959	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1117942002960	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1117942002961	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1117942002962	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1117942002963	CoenzymeA binding site [chemical binding]; other site
1117942002964	subunit interaction site [polypeptide binding]; other site
1117942002965	PHB binding site; other site
1117942002966	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1117942002967	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1117942002968	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1117942002969	oligomer interface [polypeptide binding]; other site
1117942002970	metal binding site [ion binding]; metal-binding site
1117942002971	metal binding site [ion binding]; metal-binding site
1117942002972	putative Cl binding site [ion binding]; other site
1117942002973	basic sphincter; other site
1117942002974	hydrophobic gate; other site
1117942002975	periplasmic entrance; other site
1117942002976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942002977	S-adenosylmethionine binding site [chemical binding]; other site
1117942002978	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1117942002979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117942002980	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1117942002981	metabolite-proton symporter; Region: 2A0106; TIGR00883
1117942002982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942002983	putative substrate translocation pore; other site
1117942002984	YceI-like domain; Region: YceI; pfam04264
1117942002985	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1117942002986	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1117942002987	Ligand binding site; other site
1117942002988	Putative Catalytic site; other site
1117942002989	DXD motif; other site
1117942002990	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
1117942002991	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1117942002992	putative active site [active]
1117942002993	catalytic triad [active]
1117942002994	putative dimer interface [polypeptide binding]; other site
1117942002995	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1117942002996	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1117942002997	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1117942002998	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1117942002999	precorrin-3B synthase; Region: CobG; TIGR02435
1117942003000	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1117942003001	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1117942003002	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1117942003003	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1117942003004	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1117942003005	active site
1117942003006	SAM binding site [chemical binding]; other site
1117942003007	homodimer interface [polypeptide binding]; other site
1117942003008	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1117942003009	active site
1117942003010	SAM binding site [chemical binding]; other site
1117942003011	homodimer interface [polypeptide binding]; other site
1117942003012	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1117942003013	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1117942003014	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
1117942003015	active site
1117942003016	SAM binding site [chemical binding]; other site
1117942003017	homodimer interface [polypeptide binding]; other site
1117942003018	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1117942003019	active site
1117942003020	putative homodimer interface [polypeptide binding]; other site
1117942003021	SAM binding site [chemical binding]; other site
1117942003022	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1117942003023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942003024	S-adenosylmethionine binding site [chemical binding]; other site
1117942003025	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1117942003026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942003027	NAD(P) binding site [chemical binding]; other site
1117942003028	active site
1117942003029	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1117942003030	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1117942003031	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1117942003032	active site
1117942003033	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1117942003034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942003035	ATP binding site [chemical binding]; other site
1117942003036	putative Mg++ binding site [ion binding]; other site
1117942003037	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1117942003038	nucleotide binding region [chemical binding]; other site
1117942003039	ATP-binding site [chemical binding]; other site
1117942003040	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1117942003041	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1117942003042	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
1117942003043	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1117942003044	Predicted transcriptional regulator [Transcription]; Region: COG2378
1117942003045	WYL domain; Region: WYL; pfam13280
1117942003046	Predicted transcriptional regulator [Transcription]; Region: COG2378
1117942003047	WYL domain; Region: WYL; pfam13280
1117942003048	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1117942003049	Pup-like protein; Region: Pup; pfam05639
1117942003050	Pup-ligase protein; Region: Pup_ligase; cl15463
1117942003051	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1117942003052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1117942003053	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1117942003054	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1117942003055	active site
1117942003056	metal binding site [ion binding]; metal-binding site
1117942003057	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1117942003058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1117942003059	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1117942003060	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1117942003061	Potassium binding sites [ion binding]; other site
1117942003062	Cesium cation binding sites [ion binding]; other site
1117942003063	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1117942003064	Aspartase; Region: Aspartase; cd01357
1117942003065	active sites [active]
1117942003066	tetramer interface [polypeptide binding]; other site
1117942003067	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1117942003068	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1117942003069	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1117942003070	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1117942003071	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1117942003072	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1117942003073	homodimer interface [polypeptide binding]; other site
1117942003074	putative metal binding site [ion binding]; other site
1117942003075	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1117942003076	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942003077	motif II; other site
1117942003078	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1117942003079	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1117942003080	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1117942003081	substrate binding pocket [chemical binding]; other site
1117942003082	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1117942003083	B12 binding site [chemical binding]; other site
1117942003084	cobalt ligand [ion binding]; other site
1117942003085	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1117942003086	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
1117942003087	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942003088	active site
1117942003089	HIGH motif; other site
1117942003090	nucleotide binding site [chemical binding]; other site
1117942003091	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942003092	active site
1117942003093	KMSKS motif; other site
1117942003094	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1117942003095	tRNA binding surface [nucleotide binding]; other site
1117942003096	anticodon binding site; other site
1117942003097	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1117942003098	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1117942003099	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1117942003100	active site
1117942003101	catalytic tetrad [active]
1117942003102	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1117942003103	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1117942003104	quinone interaction residues [chemical binding]; other site
1117942003105	active site
1117942003106	catalytic residues [active]
1117942003107	FMN binding site [chemical binding]; other site
1117942003108	substrate binding site [chemical binding]; other site
1117942003109	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1117942003110	substrate binding site [chemical binding]; other site
1117942003111	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1117942003112	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1117942003113	dimerization domain swap beta strand [polypeptide binding]; other site
1117942003114	regulatory protein interface [polypeptide binding]; other site
1117942003115	active site
1117942003116	regulatory phosphorylation site [posttranslational modification]; other site
1117942003117	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1117942003118	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1117942003119	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1117942003120	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1117942003121	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117942003122	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1117942003123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942003124	NAD(P) binding site [chemical binding]; other site
1117942003125	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1117942003126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942003127	NAD(P) binding site [chemical binding]; other site
1117942003128	active site
1117942003129	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1117942003130	GTP/Mg2+ binding site [chemical binding]; other site
1117942003131	G4 box; other site
1117942003132	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1117942003133	G5 box; other site
1117942003134	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1117942003135	Walker A; other site
1117942003136	G1 box; other site
1117942003137	Switch I region; other site
1117942003138	G2 box; other site
1117942003139	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1117942003140	G4 box; other site
1117942003141	G5 box; other site
1117942003142	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1117942003143	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1117942003144	active site
1117942003145	substrate binding site [chemical binding]; other site
1117942003146	coenzyme B12 binding site [chemical binding]; other site
1117942003147	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1117942003148	B12 binding site [chemical binding]; other site
1117942003149	cobalt ligand [ion binding]; other site
1117942003150	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1117942003151	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1117942003152	heterodimer interface [polypeptide binding]; other site
1117942003153	substrate interaction site [chemical binding]; other site
1117942003154	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1117942003155	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1117942003156	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1117942003157	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1117942003158	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1117942003159	ferrochelatase; Reviewed; Region: hemH; PRK00035
1117942003160	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1117942003161	C-terminal domain interface [polypeptide binding]; other site
1117942003162	active site
1117942003163	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1117942003164	active site
1117942003165	N-terminal domain interface [polypeptide binding]; other site
1117942003166	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1117942003167	NlpC/P60 family; Region: NLPC_P60; pfam00877
1117942003168	pyruvate carboxylase subunit A; Validated; Region: PRK07178
1117942003169	aconitate hydratase; Validated; Region: PRK09277
1117942003170	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1117942003171	substrate binding site [chemical binding]; other site
1117942003172	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1117942003173	ligand binding site [chemical binding]; other site
1117942003174	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1117942003175	substrate binding site [chemical binding]; other site
1117942003176	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1117942003177	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942003178	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1117942003179	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128
1117942003180	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1117942003181	catalytic triad [active]
1117942003182	conserved cys residue [active]
1117942003183	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1117942003184	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1117942003185	AAA ATPase domain; Region: AAA_16; pfam13191
1117942003186	AAA domain; Region: AAA_22; pfam13401
1117942003187	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1117942003188	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117942003189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942003190	Walker A/P-loop; other site
1117942003191	ATP binding site [chemical binding]; other site
1117942003192	Q-loop/lid; other site
1117942003193	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117942003194	ABC transporter signature motif; other site
1117942003195	Walker B; other site
1117942003196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1117942003197	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1117942003198	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1117942003199	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1117942003200	trimerization site [polypeptide binding]; other site
1117942003201	active site
1117942003202	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1117942003203	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1117942003204	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117942003205	catalytic residue [active]
1117942003206	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1117942003207	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1117942003208	Walker A/P-loop; other site
1117942003209	ATP binding site [chemical binding]; other site
1117942003210	Q-loop/lid; other site
1117942003211	ABC transporter signature motif; other site
1117942003212	Walker B; other site
1117942003213	D-loop; other site
1117942003214	H-loop/switch region; other site
1117942003215	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1117942003216	FeS assembly protein SufD; Region: sufD; TIGR01981
1117942003217	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1117942003218	FeS assembly protein SufB; Region: sufB; TIGR01980
1117942003219	Predicted transcriptional regulator [Transcription]; Region: COG2345
1117942003220	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117942003221	putative DNA binding site [nucleotide binding]; other site
1117942003222	putative Zn2+ binding site [ion binding]; other site
1117942003223	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1117942003224	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1117942003225	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1117942003226	Walker A/P-loop; other site
1117942003227	ATP binding site [chemical binding]; other site
1117942003228	Q-loop/lid; other site
1117942003229	ABC transporter signature motif; other site
1117942003230	Walker B; other site
1117942003231	D-loop; other site
1117942003232	H-loop/switch region; other site
1117942003233	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1117942003234	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1117942003235	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1117942003236	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1117942003237	UbiA prenyltransferase family; Region: UbiA; pfam01040
1117942003238	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1117942003239	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1117942003240	TPP-binding site [chemical binding]; other site
1117942003241	dimer interface [polypeptide binding]; other site
1117942003242	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1117942003243	PYR/PP interface [polypeptide binding]; other site
1117942003244	dimer interface [polypeptide binding]; other site
1117942003245	TPP binding site [chemical binding]; other site
1117942003246	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1117942003247	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1117942003248	putative active site [active]
1117942003249	transaldolase; Provisional; Region: PRK03903
1117942003250	catalytic residue [active]
1117942003251	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1117942003252	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1117942003253	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1117942003254	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1117942003255	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
1117942003256	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1117942003257	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1117942003258	putative active site [active]
1117942003259	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1117942003260	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1117942003261	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1117942003262	triosephosphate isomerase; Provisional; Region: PRK14567
1117942003263	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1117942003264	substrate binding site [chemical binding]; other site
1117942003265	dimer interface [polypeptide binding]; other site
1117942003266	catalytic triad [active]
1117942003267	Phosphoglycerate kinase; Region: PGK; pfam00162
1117942003268	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1117942003269	substrate binding site [chemical binding]; other site
1117942003270	hinge regions; other site
1117942003271	ADP binding site [chemical binding]; other site
1117942003272	catalytic site [active]
1117942003273	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1117942003274	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1117942003275	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1117942003276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1117942003277	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1117942003278	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1117942003279	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1117942003280	phosphate binding site [ion binding]; other site
1117942003281	putative substrate binding pocket [chemical binding]; other site
1117942003282	dimer interface [polypeptide binding]; other site
1117942003283	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1117942003284	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1117942003285	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1117942003286	GIY-YIG motif/motif A; other site
1117942003287	active site
1117942003288	catalytic site [active]
1117942003289	putative DNA binding site [nucleotide binding]; other site
1117942003290	metal binding site [ion binding]; metal-binding site
1117942003291	UvrB/uvrC motif; Region: UVR; pfam02151
1117942003292	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1117942003293	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1117942003294	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1117942003295	homopentamer interface [polypeptide binding]; other site
1117942003296	active site
1117942003297	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1117942003298	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1117942003299	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1117942003300	dimerization interface [polypeptide binding]; other site
1117942003301	active site
1117942003302	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1117942003303	Lumazine binding domain; Region: Lum_binding; pfam00677
1117942003304	Lumazine binding domain; Region: Lum_binding; pfam00677
1117942003305	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1117942003306	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1117942003307	catalytic motif [active]
1117942003308	Zn binding site [ion binding]; other site
1117942003309	RibD C-terminal domain; Region: RibD_C; pfam01872
1117942003310	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1117942003311	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1117942003312	substrate binding site [chemical binding]; other site
1117942003313	hexamer interface [polypeptide binding]; other site
1117942003314	metal binding site [ion binding]; metal-binding site
1117942003315	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1117942003316	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1117942003317	putative RNA binding site [nucleotide binding]; other site
1117942003318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942003319	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1117942003320	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1117942003321	putative active site [active]
1117942003322	substrate binding site [chemical binding]; other site
1117942003323	putative cosubstrate binding site; other site
1117942003324	catalytic site [active]
1117942003325	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1117942003326	substrate binding site [chemical binding]; other site
1117942003327	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1117942003328	active site
1117942003329	catalytic residues [active]
1117942003330	metal binding site [ion binding]; metal-binding site
1117942003331	primosome assembly protein PriA; Provisional; Region: PRK14873
1117942003332	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1117942003333	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1117942003334	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1117942003335	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1117942003336	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1117942003337	Flavoprotein; Region: Flavoprotein; pfam02441
1117942003338	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1117942003339	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1117942003340	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1117942003341	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1117942003342	catalytic site [active]
1117942003343	G-X2-G-X-G-K; other site
1117942003344	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1117942003345	active site
1117942003346	dimer interface [polypeptide binding]; other site
1117942003347	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1117942003348	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117942003349	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117942003350	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1117942003351	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1117942003352	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117942003353	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1117942003354	IMP binding site; other site
1117942003355	dimer interface [polypeptide binding]; other site
1117942003356	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1117942003357	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1117942003358	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1117942003359	catalytic site [active]
1117942003360	subunit interface [polypeptide binding]; other site
1117942003361	dihydroorotase; Validated; Region: pyrC; PRK09357
1117942003362	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117942003363	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1117942003364	active site
1117942003365	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1117942003366	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1117942003367	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1117942003368	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1117942003369	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942003370	active site
1117942003371	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
1117942003372	putative hydrophobic ligand binding site [chemical binding]; other site
1117942003373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942003374	TIGR01777 family protein; Region: yfcH
1117942003375	NAD(P) binding site [chemical binding]; other site
1117942003376	active site
1117942003377	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1117942003378	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1117942003379	putative RNA binding site [nucleotide binding]; other site
1117942003380	elongation factor P; Validated; Region: PRK00529
1117942003381	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1117942003382	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1117942003383	RNA binding site [nucleotide binding]; other site
1117942003384	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1117942003385	RNA binding site [nucleotide binding]; other site
1117942003386	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1117942003387	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1117942003388	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1117942003389	active site
1117942003390	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1117942003391	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1117942003392	trimer interface [polypeptide binding]; other site
1117942003393	active site
1117942003394	dimer interface [polypeptide binding]; other site
1117942003395	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1117942003396	active site
1117942003397	dimer interface [polypeptide binding]; other site
1117942003398	metal binding site [ion binding]; metal-binding site
1117942003399	shikimate kinase; Reviewed; Region: aroK; PRK00131
1117942003400	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1117942003401	ADP binding site [chemical binding]; other site
1117942003402	magnesium binding site [ion binding]; other site
1117942003403	putative shikimate binding site; other site
1117942003404	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1117942003405	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1117942003406	Tetramer interface [polypeptide binding]; other site
1117942003407	active site
1117942003408	FMN-binding site [chemical binding]; other site
1117942003409	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1117942003410	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1117942003411	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1117942003412	shikimate binding site; other site
1117942003413	NAD(P) binding site [chemical binding]; other site
1117942003414	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1117942003415	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1117942003416	dimerization interface [polypeptide binding]; other site
1117942003417	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1117942003418	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1117942003419	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1117942003420	motif 1; other site
1117942003421	active site
1117942003422	motif 2; other site
1117942003423	motif 3; other site
1117942003424	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1117942003425	DHHA1 domain; Region: DHHA1; pfam02272
1117942003426	recombination factor protein RarA; Reviewed; Region: PRK13342
1117942003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942003428	Walker A motif; other site
1117942003429	ATP binding site [chemical binding]; other site
1117942003430	Walker B motif; other site
1117942003431	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1117942003432	Phosphotransferase enzyme family; Region: APH; pfam01636
1117942003433	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1117942003434	substrate binding site [chemical binding]; other site
1117942003435	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1117942003436	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1117942003437	dimer interface [polypeptide binding]; other site
1117942003438	anticodon binding site; other site
1117942003439	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1117942003440	homodimer interface [polypeptide binding]; other site
1117942003441	motif 1; other site
1117942003442	active site
1117942003443	motif 2; other site
1117942003444	GAD domain; Region: GAD; pfam02938
1117942003445	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117942003446	active site
1117942003447	motif 3; other site
1117942003448	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1117942003449	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1117942003450	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942003451	ATP binding site [chemical binding]; other site
1117942003452	putative Mg++ binding site [ion binding]; other site
1117942003453	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942003454	nucleotide binding region [chemical binding]; other site
1117942003455	ATP-binding site [chemical binding]; other site
1117942003456	Predicted membrane protein [Function unknown]; Region: COG1511
1117942003457	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1117942003458	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1117942003459	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1117942003460	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1117942003461	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
1117942003462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942003463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942003464	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1117942003465	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1117942003466	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1117942003467	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1117942003468	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1117942003469	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1117942003470	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1117942003471	putative active site [active]
1117942003472	putative catalytic site [active]
1117942003473	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1117942003474	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1117942003475	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1117942003476	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1117942003477	dimer interface [polypeptide binding]; other site
1117942003478	motif 1; other site
1117942003479	active site
1117942003480	motif 2; other site
1117942003481	motif 3; other site
1117942003482	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1117942003483	anticodon binding site; other site
1117942003484	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1117942003485	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1117942003486	dimer interface [polypeptide binding]; other site
1117942003487	catalytic triad [active]
1117942003488	peroxidatic and resolving cysteines [active]
1117942003489	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1117942003490	active site
1117942003491	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1117942003492	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117942003493	Zn2+ binding site [ion binding]; other site
1117942003494	Mg2+ binding site [ion binding]; other site
1117942003495	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1117942003496	synthetase active site [active]
1117942003497	NTP binding site [chemical binding]; other site
1117942003498	metal binding site [ion binding]; metal-binding site
1117942003499	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1117942003500	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1117942003501	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942003502	active site
1117942003503	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1117942003504	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1117942003505	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1117942003506	Protein export membrane protein; Region: SecD_SecF; pfam02355
1117942003507	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
1117942003508	Protein export membrane protein; Region: SecD_SecF; cl14618
1117942003509	Preprotein translocase subunit; Region: YajC; pfam02699
1117942003510	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1117942003511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942003512	Walker A motif; other site
1117942003513	ATP binding site [chemical binding]; other site
1117942003514	Walker B motif; other site
1117942003515	arginine finger; other site
1117942003516	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1117942003517	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1117942003518	RuvA N terminal domain; Region: RuvA_N; pfam01330
1117942003519	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1117942003520	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1117942003521	active site
1117942003522	putative DNA-binding cleft [nucleotide binding]; other site
1117942003523	dimer interface [polypeptide binding]; other site
1117942003524	hypothetical protein; Validated; Region: PRK00110
1117942003525	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1117942003526	active site
1117942003527	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1117942003528	catalytic triad [active]
1117942003529	dimer interface [polypeptide binding]; other site
1117942003530	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1117942003531	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
1117942003532	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1117942003533	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1117942003534	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1117942003535	catalytic residue [active]
1117942003536	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117942003537	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117942003538	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1117942003539	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1117942003540	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1117942003541	putative acyl-acceptor binding pocket; other site
1117942003542	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1117942003543	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1117942003544	nucleotide binding site/active site [active]
1117942003545	HIT family signature motif; other site
1117942003546	catalytic residue [active]
1117942003547	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1117942003548	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1117942003549	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1117942003550	active site
1117942003551	dimer interface [polypeptide binding]; other site
1117942003552	motif 1; other site
1117942003553	motif 2; other site
1117942003554	motif 3; other site
1117942003555	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1117942003556	anticodon binding site; other site
1117942003557	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1117942003558	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1117942003559	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1117942003560	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1117942003561	hypothetical protein; Provisional; Region: PRK14059
1117942003562	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1117942003563	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1117942003564	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1117942003565	SelR domain; Region: SelR; pfam01641
1117942003566	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1117942003567	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1117942003568	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1117942003569	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1117942003570	catalytic site [active]
1117942003571	putative active site [active]
1117942003572	putative substrate binding site [chemical binding]; other site
1117942003573	HRDC domain; Region: HRDC; pfam00570
1117942003574	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1117942003575	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1117942003576	TPP-binding site; other site
1117942003577	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1117942003578	PYR/PP interface [polypeptide binding]; other site
1117942003579	dimer interface [polypeptide binding]; other site
1117942003580	TPP binding site [chemical binding]; other site
1117942003581	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1117942003582	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1117942003583	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1117942003584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942003585	S-adenosylmethionine binding site [chemical binding]; other site
1117942003586	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1117942003587	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1117942003588	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1117942003589	trimer interface [polypeptide binding]; other site
1117942003590	active site
1117942003591	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1117942003592	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1117942003593	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1117942003594	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1117942003595	nucleotide binding site [chemical binding]; other site
1117942003596	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1117942003597	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1117942003598	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942003599	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1117942003600	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942003601	DNA binding residues [nucleotide binding]
1117942003602	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1117942003603	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942003604	ATP binding site [chemical binding]; other site
1117942003605	putative Mg++ binding site [ion binding]; other site
1117942003606	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1117942003607	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1117942003608	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1117942003609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942003610	S-adenosylmethionine binding site [chemical binding]; other site
1117942003611	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1117942003612	putative active site [active]
1117942003613	dimerization interface [polypeptide binding]; other site
1117942003614	putative tRNAtyr binding site [nucleotide binding]; other site
1117942003615	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1117942003616	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1117942003617	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942003618	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1117942003619	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942003620	DNA binding residues [nucleotide binding]
1117942003621	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1117942003622	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1117942003623	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1117942003624	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1117942003625	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1117942003626	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1117942003627	NAD binding site [chemical binding]; other site
1117942003628	homodimer interface [polypeptide binding]; other site
1117942003629	active site
1117942003630	substrate binding site [chemical binding]; other site
1117942003631	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1117942003632	PAC2 family; Region: PAC2; pfam09754
1117942003633	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1117942003634	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942003635	ATP binding site [chemical binding]; other site
1117942003636	putative Mg++ binding site [ion binding]; other site
1117942003637	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942003638	nucleotide binding region [chemical binding]; other site
1117942003639	ATP-binding site [chemical binding]; other site
1117942003640	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
1117942003641	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1117942003642	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1117942003643	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1117942003644	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1117942003645	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1117942003646	catalytic triad [active]
1117942003647	dimer interface [polypeptide binding]; other site
1117942003648	peroxidatic and resolving cysteines [active]
1117942003649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1117942003650	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1117942003651	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1117942003652	dimerization interface [polypeptide binding]; other site
1117942003653	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1117942003654	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1117942003655	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942003656	ATP binding site [chemical binding]; other site
1117942003657	putative Mg++ binding site [ion binding]; other site
1117942003658	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1117942003659	nucleotide binding region [chemical binding]; other site
1117942003660	ATP-binding site [chemical binding]; other site
1117942003661	Helicase associated domain (HA2); Region: HA2; pfam04408
1117942003662	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1117942003663	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1117942003664	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1117942003665	ATP cone domain; Region: ATP-cone; pfam03477
1117942003666	LexA repressor; Validated; Region: PRK00215
1117942003667	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1117942003668	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1117942003669	Catalytic site [active]
1117942003670	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1117942003671	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1117942003672	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1117942003673	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1117942003674	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1117942003675	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1117942003676	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1117942003677	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1117942003678	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117942003679	DNA-binding site [nucleotide binding]; DNA binding site
1117942003680	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1117942003681	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1117942003682	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1117942003683	putative substrate binding site [chemical binding]; other site
1117942003684	putative ATP binding site [chemical binding]; other site
1117942003685	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1117942003686	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1117942003687	active site
1117942003688	phosphorylation site [posttranslational modification]
1117942003689	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1117942003690	active site
1117942003691	P-loop; other site
1117942003692	phosphorylation site [posttranslational modification]
1117942003693	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1117942003694	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1117942003695	dimerization domain swap beta strand [polypeptide binding]; other site
1117942003696	regulatory protein interface [polypeptide binding]; other site
1117942003697	active site
1117942003698	regulatory phosphorylation site [posttranslational modification]; other site
1117942003699	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1117942003700	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1117942003701	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1117942003702	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1117942003703	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1117942003704	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1117942003705	GTPases [General function prediction only]; Region: HflX; COG2262
1117942003706	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1117942003707	HflX GTPase family; Region: HflX; cd01878
1117942003708	G1 box; other site
1117942003709	GTP/Mg2+ binding site [chemical binding]; other site
1117942003710	Switch I region; other site
1117942003711	G2 box; other site
1117942003712	G3 box; other site
1117942003713	Switch II region; other site
1117942003714	G4 box; other site
1117942003715	G5 box; other site
1117942003716	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1117942003717	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1117942003718	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1117942003719	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1117942003720	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1117942003721	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1117942003722	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1117942003723	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1117942003724	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1117942003725	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1117942003726	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942003727	FeS/SAM binding site; other site
1117942003728	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1117942003729	recombinase A; Provisional; Region: recA; PRK09354
1117942003730	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1117942003731	hexamer interface [polypeptide binding]; other site
1117942003732	Walker A motif; other site
1117942003733	ATP binding site [chemical binding]; other site
1117942003734	Walker B motif; other site
1117942003735	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1117942003736	BioY family; Region: BioY; pfam02632
1117942003737	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1117942003738	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1117942003739	Walker A/P-loop; other site
1117942003740	ATP binding site [chemical binding]; other site
1117942003741	Q-loop/lid; other site
1117942003742	ABC transporter signature motif; other site
1117942003743	Walker B; other site
1117942003744	D-loop; other site
1117942003745	H-loop/switch region; other site
1117942003746	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1117942003747	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1117942003748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1117942003749	sequence-specific DNA binding site [nucleotide binding]; other site
1117942003750	salt bridge; other site
1117942003751	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1117942003752	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1117942003753	YCII-related domain; Region: YCII; cl00999
1117942003754	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1117942003755	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1117942003756	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1117942003757	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1117942003758	TIGR03085 family protein; Region: TIGR03085
1117942003759	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1117942003760	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1117942003761	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1117942003762	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1117942003763	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1117942003764	dimer interface [polypeptide binding]; other site
1117942003765	active site
1117942003766	catalytic residue [active]
1117942003767	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1117942003768	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1117942003769	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1117942003770	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1117942003771	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1117942003772	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1117942003773	oligomer interface [polypeptide binding]; other site
1117942003774	RNA binding site [nucleotide binding]; other site
1117942003775	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1117942003776	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1117942003777	RNase E interface [polypeptide binding]; other site
1117942003778	trimer interface [polypeptide binding]; other site
1117942003779	active site
1117942003780	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1117942003781	putative nucleic acid binding region [nucleotide binding]; other site
1117942003782	G-X-X-G motif; other site
1117942003783	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1117942003784	RNA binding site [nucleotide binding]; other site
1117942003785	domain interface; other site
1117942003786	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1117942003787	16S/18S rRNA binding site [nucleotide binding]; other site
1117942003788	S13e-L30e interaction site [polypeptide binding]; other site
1117942003789	25S rRNA binding site [nucleotide binding]; other site
1117942003790	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1117942003791	active site
1117942003792	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1117942003793	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1117942003794	active site
1117942003795	Riboflavin kinase; Region: Flavokinase; smart00904
1117942003796	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1117942003797	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1117942003798	RNA binding site [nucleotide binding]; other site
1117942003799	active site
1117942003800	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1117942003801	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1117942003802	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1117942003803	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1117942003804	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1117942003805	active site
1117942003806	metal binding site [ion binding]; metal-binding site
1117942003807	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1117942003808	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1117942003809	DHH family; Region: DHH; pfam01368
1117942003810	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1117942003811	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1117942003812	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1117942003813	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1117942003814	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1117942003815	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1117942003816	G1 box; other site
1117942003817	putative GEF interaction site [polypeptide binding]; other site
1117942003818	GTP/Mg2+ binding site [chemical binding]; other site
1117942003819	Switch I region; other site
1117942003820	G2 box; other site
1117942003821	G3 box; other site
1117942003822	Switch II region; other site
1117942003823	G4 box; other site
1117942003824	G5 box; other site
1117942003825	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1117942003826	Translation-initiation factor 2; Region: IF-2; pfam11987
1117942003827	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1117942003828	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1117942003829	putative RNA binding cleft [nucleotide binding]; other site
1117942003830	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1117942003831	NusA N-terminal domain; Region: NusA_N; pfam08529
1117942003832	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1117942003833	RNA binding site [nucleotide binding]; other site
1117942003834	homodimer interface [polypeptide binding]; other site
1117942003835	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1117942003836	G-X-X-G motif; other site
1117942003837	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1117942003838	G-X-X-G motif; other site
1117942003839	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1117942003840	Sm and related proteins; Region: Sm_like; cl00259
1117942003841	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1117942003842	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1117942003843	dimer interface [polypeptide binding]; other site
1117942003844	motif 1; other site
1117942003845	active site
1117942003846	motif 2; other site
1117942003847	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1117942003848	putative deacylase active site [active]
1117942003849	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117942003850	active site
1117942003851	motif 3; other site
1117942003852	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1117942003853	anticodon binding site; other site
1117942003854	hypothetical protein; Validated; Region: PRK02101
1117942003855	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1117942003856	active site
1117942003857	SAM binding site [chemical binding]; other site
1117942003858	homodimer interface [polypeptide binding]; other site
1117942003859	hypothetical protein; Validated; Region: PRK00029
1117942003860	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1117942003861	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1117942003862	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1117942003863	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1117942003864	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1117942003865	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1117942003866	DNA binding site [nucleotide binding]
1117942003867	active site
1117942003868	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1117942003869	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1117942003870	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1117942003871	catalytic triad [active]
1117942003872	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1117942003873	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1117942003874	homodimer interface [polypeptide binding]; other site
1117942003875	Walker A motif; other site
1117942003876	ATP binding site [chemical binding]; other site
1117942003877	hydroxycobalamin binding site [chemical binding]; other site
1117942003878	Walker B motif; other site
1117942003879	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
1117942003880	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1117942003881	metal ion-dependent adhesion site (MIDAS); other site
1117942003882	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1117942003883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942003884	Walker A motif; other site
1117942003885	ATP binding site [chemical binding]; other site
1117942003886	Walker B motif; other site
1117942003887	arginine finger; other site
1117942003888	malate:quinone oxidoreductase; Validated; Region: PRK05257
1117942003889	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1117942003890	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1117942003891	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117942003892	mycothione reductase; Reviewed; Region: PRK07846
1117942003893	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117942003894	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1117942003895	cobyric acid synthase; Provisional; Region: PRK00784
1117942003896	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1117942003897	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1117942003898	catalytic triad [active]
1117942003899	methionine aminopeptidase; Provisional; Region: PRK12318
1117942003900	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1117942003901	active site
1117942003902	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1117942003903	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1117942003904	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1117942003905	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1117942003906	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1117942003907	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1117942003908	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1117942003909	active site
1117942003910	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1117942003911	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1117942003912	putative substrate binding region [chemical binding]; other site
1117942003913	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1117942003914	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1117942003915	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1117942003916	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1117942003917	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1117942003918	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1117942003919	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1117942003920	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1117942003921	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1117942003922	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1117942003923	hinge region; other site
1117942003924	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1117942003925	putative nucleotide binding site [chemical binding]; other site
1117942003926	uridine monophosphate binding site [chemical binding]; other site
1117942003927	homohexameric interface [polypeptide binding]; other site
1117942003928	elongation factor Ts; Provisional; Region: tsf; PRK09377
1117942003929	UBA/TS-N domain; Region: UBA; pfam00627
1117942003930	Elongation factor TS; Region: EF_TS; pfam00889
1117942003931	Elongation factor TS; Region: EF_TS; pfam00889
1117942003932	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1117942003933	rRNA interaction site [nucleotide binding]; other site
1117942003934	S8 interaction site; other site
1117942003935	putative laminin-1 binding site; other site
1117942003936	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1117942003937	Peptidase family M23; Region: Peptidase_M23; pfam01551
1117942003938	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1117942003939	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1117942003940	active site
1117942003941	DNA binding site [nucleotide binding]
1117942003942	Int/Topo IB signature motif; other site
1117942003943	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1117942003944	DNA protecting protein DprA; Region: dprA; TIGR00732
1117942003945	hypothetical protein; Reviewed; Region: PRK12497
1117942003946	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1117942003947	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1117942003948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942003949	Walker A motif; other site
1117942003950	ATP binding site [chemical binding]; other site
1117942003951	Walker B motif; other site
1117942003952	arginine finger; other site
1117942003953	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1117942003954	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1117942003955	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1117942003956	RNA/DNA hybrid binding site [nucleotide binding]; other site
1117942003957	active site
1117942003958	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1117942003959	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1117942003960	Catalytic site [active]
1117942003961	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1117942003962	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1117942003963	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1117942003964	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1117942003965	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1117942003966	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1117942003967	RNA binding site [nucleotide binding]; other site
1117942003968	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1117942003969	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1117942003970	active site
1117942003971	P-loop; other site
1117942003972	phosphorylation site [posttranslational modification]
1117942003973	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1117942003974	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1117942003975	active site
1117942003976	phosphorylation site [posttranslational modification]
1117942003977	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1117942003978	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1117942003979	RimM N-terminal domain; Region: RimM; pfam01782
1117942003980	PRC-barrel domain; Region: PRC; pfam05239
1117942003981	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1117942003982	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1117942003983	signal recognition particle protein; Provisional; Region: PRK10867
1117942003984	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1117942003985	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1117942003986	P loop; other site
1117942003987	GTP binding site [chemical binding]; other site
1117942003988	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1117942003989	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
1117942003990	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1117942003991	metal binding triad; other site
1117942003992	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1117942003993	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117942003994	Zn2+ binding site [ion binding]; other site
1117942003995	Mg2+ binding site [ion binding]; other site
1117942003996	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1117942003997	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1117942003998	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1117942003999	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1117942004000	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1117942004001	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1117942004002	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1117942004003	Walker A/P-loop; other site
1117942004004	ATP binding site [chemical binding]; other site
1117942004005	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
1117942004006	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1117942004007	ABC transporter signature motif; other site
1117942004008	Walker B; other site
1117942004009	D-loop; other site
1117942004010	H-loop/switch region; other site
1117942004011	Acylphosphatase; Region: Acylphosphatase; cl00551
1117942004012	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1117942004013	amino acid carrier protein; Region: agcS; TIGR00835
1117942004014	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1117942004015	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1117942004016	DNA binding site [nucleotide binding]
1117942004017	catalytic residue [active]
1117942004018	H2TH interface [polypeptide binding]; other site
1117942004019	putative catalytic residues [active]
1117942004020	turnover-facilitating residue; other site
1117942004021	intercalation triad [nucleotide binding]; other site
1117942004022	8OG recognition residue [nucleotide binding]; other site
1117942004023	putative reading head residues; other site
1117942004024	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1117942004025	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1117942004026	ribonuclease III; Reviewed; Region: rnc; PRK00102
1117942004027	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1117942004028	dimerization interface [polypeptide binding]; other site
1117942004029	active site
1117942004030	metal binding site [ion binding]; metal-binding site
1117942004031	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1117942004032	dsRNA binding site [nucleotide binding]; other site
1117942004033	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1117942004034	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1117942004035	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1117942004036	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1117942004037	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1117942004038	hexamer interface [polypeptide binding]; other site
1117942004039	ligand binding site [chemical binding]; other site
1117942004040	putative active site [active]
1117942004041	NAD(P) binding site [chemical binding]; other site
1117942004042	glutamate dehydrogenase; Provisional; Region: PRK09414
1117942004043	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1117942004044	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1117942004045	NAD(P) binding site [chemical binding]; other site
1117942004046	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1117942004047	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1117942004048	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1117942004049	nucleotide binding site/active site [active]
1117942004050	HIT family signature motif; other site
1117942004051	catalytic residue [active]
1117942004052	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1117942004053	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1117942004054	metal binding site [ion binding]; metal-binding site
1117942004055	putative dimer interface [polypeptide binding]; other site
1117942004056	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1117942004057	homodimer interface [polypeptide binding]; other site
1117942004058	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1117942004059	active site pocket [active]
1117942004060	Electron transfer DM13; Region: DM13; pfam10517
1117942004061	pyruvate kinase; Provisional; Region: PRK06247
1117942004062	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1117942004063	domain interfaces; other site
1117942004064	active site
1117942004065	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1117942004066	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1117942004067	active site
1117942004068	ribulose/triose binding site [chemical binding]; other site
1117942004069	phosphate binding site [ion binding]; other site
1117942004070	substrate (anthranilate) binding pocket [chemical binding]; other site
1117942004071	product (indole) binding pocket [chemical binding]; other site
1117942004072	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1117942004073	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1117942004074	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1117942004075	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1117942004076	substrate binding site [chemical binding]; other site
1117942004077	glutamase interaction surface [polypeptide binding]; other site
1117942004078	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1117942004079	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1117942004080	active site
1117942004081	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1117942004082	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1117942004083	catalytic residues [active]
1117942004084	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1117942004085	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1117942004086	putative active site [active]
1117942004087	oxyanion strand; other site
1117942004088	catalytic triad [active]
1117942004089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942004090	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942004091	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1117942004092	putative active site pocket [active]
1117942004093	4-fold oligomerization interface [polypeptide binding]; other site
1117942004094	metal binding residues [ion binding]; metal-binding site
1117942004095	3-fold/trimer interface [polypeptide binding]; other site
1117942004096	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1117942004097	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117942004098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004099	homodimer interface [polypeptide binding]; other site
1117942004100	catalytic residue [active]
1117942004101	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1117942004102	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1117942004103	NAD binding site [chemical binding]; other site
1117942004104	dimerization interface [polypeptide binding]; other site
1117942004105	product binding site; other site
1117942004106	substrate binding site [chemical binding]; other site
1117942004107	zinc binding site [ion binding]; other site
1117942004108	catalytic residues [active]
1117942004109	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1117942004110	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1117942004111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942004112	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1117942004113	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1117942004114	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1117942004115	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1117942004116	active site
1117942004117	catalytic site [active]
1117942004118	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
1117942004119	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1117942004120	active site
1117942004121	catalytic site [active]
1117942004122	substrate binding site [chemical binding]; other site
1117942004123	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1117942004124	Dimer interface [polypeptide binding]; other site
1117942004125	BRCT sequence motif; other site
1117942004126	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1117942004127	synthetase active site [active]
1117942004128	NTP binding site [chemical binding]; other site
1117942004129	metal binding site [ion binding]; metal-binding site
1117942004130	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1117942004131	RNA binding surface [nucleotide binding]; other site
1117942004132	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1117942004133	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1117942004134	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1117942004135	threonine dehydratase; Validated; Region: PRK08639
1117942004136	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1117942004137	tetramer interface [polypeptide binding]; other site
1117942004138	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004139	catalytic residue [active]
1117942004140	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1117942004141	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1117942004142	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1117942004143	active site
1117942004144	PHP Thumb interface [polypeptide binding]; other site
1117942004145	metal binding site [ion binding]; metal-binding site
1117942004146	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1117942004147	generic binding surface I; other site
1117942004148	generic binding surface II; other site
1117942004149	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1117942004150	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1117942004151	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1117942004152	RNA binding surface [nucleotide binding]; other site
1117942004153	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1117942004154	active site
1117942004155	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1117942004156	lipoprotein signal peptidase; Provisional; Region: PRK14787
1117942004157	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1117942004158	active site
1117942004159	homotetramer interface [polypeptide binding]; other site
1117942004160	homodimer interface [polypeptide binding]; other site
1117942004161	DNA polymerase IV; Provisional; Region: PRK03348
1117942004162	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1117942004163	active site
1117942004164	DNA binding site [nucleotide binding]
1117942004165	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1117942004166	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1117942004167	HIGH motif; other site
1117942004168	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1117942004169	active site
1117942004170	KMSKS motif; other site
1117942004171	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1117942004172	tRNA binding surface [nucleotide binding]; other site
1117942004173	anticodon binding site; other site
1117942004174	DivIVA protein; Region: DivIVA; pfam05103
1117942004175	DivIVA domain; Region: DivI1A_domain; TIGR03544
1117942004176	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1117942004177	YGGT family; Region: YGGT; pfam02325
1117942004178	Protein of unknown function (DUF552); Region: DUF552; cl00775
1117942004179	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1117942004180	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1117942004181	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
1117942004182	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1117942004183	nucleotide binding site [chemical binding]; other site
1117942004184	SulA interaction site; other site
1117942004185	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1117942004186	Cell division protein FtsQ; Region: FtsQ; pfam03799
1117942004187	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1117942004188	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117942004189	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117942004190	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117942004191	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1117942004192	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1117942004193	homodimer interface [polypeptide binding]; other site
1117942004194	active site
1117942004195	cell division protein FtsW; Region: ftsW; TIGR02614
1117942004196	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1117942004197	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1117942004198	Mg++ binding site [ion binding]; other site
1117942004199	putative catalytic motif [active]
1117942004200	putative substrate binding site [chemical binding]; other site
1117942004201	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1117942004202	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117942004203	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117942004204	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117942004205	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1117942004206	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1117942004207	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117942004208	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117942004209	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1117942004210	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1117942004211	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1117942004212	MraW methylase family; Region: Methyltransf_5; cl17771
1117942004213	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1117942004214	cell division protein MraZ; Reviewed; Region: PRK00326
1117942004215	MraZ protein; Region: MraZ; pfam02381
1117942004216	MraZ protein; Region: MraZ; pfam02381
1117942004217	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1117942004218	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1117942004219	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1117942004220	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1117942004221	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1117942004222	substrate binding pocket [chemical binding]; other site
1117942004223	chain length determination region; other site
1117942004224	substrate-Mg2+ binding site; other site
1117942004225	catalytic residues [active]
1117942004226	aspartate-rich region 1; other site
1117942004227	active site lid residues [active]
1117942004228	aspartate-rich region 2; other site
1117942004229	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1117942004230	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117942004231	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117942004232	active site
1117942004233	ATP binding site [chemical binding]; other site
1117942004234	substrate binding site [chemical binding]; other site
1117942004235	activation loop (A-loop); other site
1117942004236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1117942004237	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942004238	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942004239	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942004240	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1117942004241	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1117942004242	Predicted membrane protein [Function unknown]; Region: COG4763
1117942004243	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1117942004244	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1117942004245	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1117942004246	putative acyl-acceptor binding pocket; other site
1117942004247	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1117942004248	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1117942004249	nucleotide binding site [chemical binding]; other site
1117942004250	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117942004251	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117942004252	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1117942004253	NlpC/P60 family; Region: NLPC_P60; pfam00877
1117942004254	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1117942004255	NlpC/P60 family; Region: NLPC_P60; pfam00877
1117942004256	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1117942004257	heme bH binding site [chemical binding]; other site
1117942004258	intrachain domain interface; other site
1117942004259	heme bL binding site [chemical binding]; other site
1117942004260	interchain domain interface [polypeptide binding]; other site
1117942004261	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1117942004262	Qo binding site; other site
1117942004263	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1117942004264	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1117942004265	iron-sulfur cluster [ion binding]; other site
1117942004266	[2Fe-2S] cluster binding site [ion binding]; other site
1117942004267	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1117942004268	Cytochrome c; Region: Cytochrom_C; pfam00034
1117942004269	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1117942004270	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1117942004271	Subunit I/III interface [polypeptide binding]; other site
1117942004272	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1117942004273	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1117942004274	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1117942004275	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1117942004276	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1117942004277	active site
1117942004278	dimer interface [polypeptide binding]; other site
1117942004279	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1117942004280	Ligand Binding Site [chemical binding]; other site
1117942004281	Molecular Tunnel; other site
1117942004282	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1117942004283	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1117942004284	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1117942004285	homotrimer interface [polypeptide binding]; other site
1117942004286	Walker A motif; other site
1117942004287	GTP binding site [chemical binding]; other site
1117942004288	Walker B motif; other site
1117942004289	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1117942004290	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1117942004291	putative dimer interface [polypeptide binding]; other site
1117942004292	active site pocket [active]
1117942004293	putative cataytic base [active]
1117942004294	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1117942004295	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1117942004296	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1117942004297	homodimer interface [polypeptide binding]; other site
1117942004298	substrate-cofactor binding pocket; other site
1117942004299	catalytic residue [active]
1117942004300	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1117942004301	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1117942004302	interface (dimer of trimers) [polypeptide binding]; other site
1117942004303	Substrate-binding/catalytic site; other site
1117942004304	Zn-binding sites [ion binding]; other site
1117942004305	glycine dehydrogenase; Provisional; Region: PRK05367
1117942004306	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1117942004307	tetramer interface [polypeptide binding]; other site
1117942004308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004309	catalytic residue [active]
1117942004310	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1117942004311	tetramer interface [polypeptide binding]; other site
1117942004312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004313	catalytic residue [active]
1117942004314	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1117942004315	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1117942004316	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1117942004317	lipoyl attachment site [posttranslational modification]; other site
1117942004318	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1117942004319	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1117942004320	active site
1117942004321	lipoate-protein ligase B; Provisional; Region: PRK14345
1117942004322	lipoyl synthase; Provisional; Region: PRK05481
1117942004323	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942004324	FeS/SAM binding site; other site
1117942004325	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1117942004326	RDD family; Region: RDD; pfam06271
1117942004327	glutamine synthetase, type I; Region: GlnA; TIGR00653
1117942004328	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1117942004329	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1117942004330	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1117942004331	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
1117942004332	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
1117942004333	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1117942004334	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1117942004335	DNA methylase; Region: N6_N4_Mtase; pfam01555
1117942004336	DNA methylase; Region: N6_N4_Mtase; cl17433
1117942004337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942004338	AAA domain; Region: AAA_21; pfam13304
1117942004339	Walker A/P-loop; other site
1117942004340	ATP binding site [chemical binding]; other site
1117942004341	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1117942004342	putative active site [active]
1117942004343	putative metal-binding site [ion binding]; other site
1117942004344	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
1117942004345	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1117942004346	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1117942004347	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1117942004348	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1117942004349	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1117942004350	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117942004351	Walker A/P-loop; other site
1117942004352	ATP binding site [chemical binding]; other site
1117942004353	Q-loop/lid; other site
1117942004354	ABC transporter signature motif; other site
1117942004355	Walker B; other site
1117942004356	D-loop; other site
1117942004357	H-loop/switch region; other site
1117942004358	Htaa; Region: HtaA; pfam04213
1117942004359	Htaa; Region: HtaA; pfam04213
1117942004360	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1117942004361	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1117942004362	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1117942004363	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
1117942004364	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1117942004365	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1117942004366	active site
1117942004367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1117942004368	Predicted permease [General function prediction only]; Region: COG2056
1117942004369	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1117942004370	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
1117942004371	nudix motif; other site
1117942004372	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1117942004373	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1117942004374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004375	catalytic residue [active]
1117942004376	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1117942004377	active site
1117942004378	catalytic site [active]
1117942004379	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1117942004380	heme binding pocket [chemical binding]; other site
1117942004381	heme ligand [chemical binding]; other site
1117942004382	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1117942004383	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1117942004384	metal binding triad; other site
1117942004385	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1117942004386	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1117942004387	metal binding triad; other site
1117942004388	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1117942004389	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1117942004390	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1117942004391	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1117942004392	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1117942004393	putative active site; other site
1117942004394	putative metal binding residues [ion binding]; other site
1117942004395	signature motif; other site
1117942004396	putative triphosphate binding site [ion binding]; other site
1117942004397	CHAD domain; Region: CHAD; pfam05235
1117942004398	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1117942004399	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1117942004400	RNB domain; Region: RNB; pfam00773
1117942004401	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1117942004402	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1117942004403	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1117942004404	RNA/DNA hybrid binding site [nucleotide binding]; other site
1117942004405	active site
1117942004406	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942004407	catalytic core [active]
1117942004408	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1117942004409	Putative zinc ribbon domain; Region: DUF164; pfam02591
1117942004410	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1117942004411	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1117942004412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1117942004413	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1117942004414	hypothetical protein; Provisional; Region: PRK07908
1117942004415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117942004416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004417	homodimer interface [polypeptide binding]; other site
1117942004418	catalytic residue [active]
1117942004419	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1117942004420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942004421	motif II; other site
1117942004422	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1117942004423	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1117942004424	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1117942004425	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1117942004426	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1117942004427	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1117942004428	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1117942004429	dimer interface [polypeptide binding]; other site
1117942004430	TPP-binding site [chemical binding]; other site
1117942004431	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1117942004432	Serine hydrolase; Region: Ser_hydrolase; cl17834
1117942004433	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1117942004434	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1117942004435	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1117942004436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942004437	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1117942004438	Beta-lactamase; Region: Beta-lactamase; pfam00144
1117942004439	Predicted membrane protein [Function unknown]; Region: COG2860
1117942004440	UPF0126 domain; Region: UPF0126; pfam03458
1117942004441	UPF0126 domain; Region: UPF0126; pfam03458
1117942004442	DNA primase; Validated; Region: dnaG; PRK05667
1117942004443	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1117942004444	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1117942004445	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1117942004446	active site
1117942004447	metal binding site [ion binding]; metal-binding site
1117942004448	interdomain interaction site; other site
1117942004449	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1117942004450	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1117942004451	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1117942004452	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1117942004453	glutaminase active site [active]
1117942004454	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1117942004455	dimer interface [polypeptide binding]; other site
1117942004456	active site
1117942004457	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1117942004458	dimer interface [polypeptide binding]; other site
1117942004459	active site
1117942004460	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1117942004461	active site
1117942004462	barstar interaction site; other site
1117942004463	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1117942004464	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117942004465	Zn2+ binding site [ion binding]; other site
1117942004466	Mg2+ binding site [ion binding]; other site
1117942004467	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1117942004468	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1117942004469	putative active site [active]
1117942004470	Repair protein; Region: Repair_PSII; pfam04536
1117942004471	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1117942004472	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117942004473	motif 1; other site
1117942004474	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1117942004475	active site
1117942004476	motif 2; other site
1117942004477	motif 3; other site
1117942004478	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1117942004479	anticodon binding site; other site
1117942004480	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117942004481	putative DNA binding site [nucleotide binding]; other site
1117942004482	putative Zn2+ binding site [ion binding]; other site
1117942004483	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1117942004484	metal binding site 2 [ion binding]; metal-binding site
1117942004485	putative DNA binding helix; other site
1117942004486	metal binding site 1 [ion binding]; metal-binding site
1117942004487	dimer interface [polypeptide binding]; other site
1117942004488	structural Zn2+ binding site [ion binding]; other site
1117942004489	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1117942004490	diiron binding motif [ion binding]; other site
1117942004491	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
1117942004492	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1117942004493	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1117942004494	catalytic residue [active]
1117942004495	putative FPP diphosphate  binding site; other site
1117942004496	putative FPP binding hydrophobic cleft; other site
1117942004497	dimer interface [polypeptide binding]; other site
1117942004498	putative IPP diphosphate binding site; other site
1117942004499	Recombination protein O N terminal; Region: RecO_N; pfam11967
1117942004500	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1117942004501	Recombination protein O C terminal; Region: RecO_C; pfam02565
1117942004502	GTPase Era; Reviewed; Region: era; PRK00089
1117942004503	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1117942004504	G1 box; other site
1117942004505	GTP/Mg2+ binding site [chemical binding]; other site
1117942004506	Switch I region; other site
1117942004507	G2 box; other site
1117942004508	Switch II region; other site
1117942004509	G3 box; other site
1117942004510	G4 box; other site
1117942004511	G5 box; other site
1117942004512	KH domain; Region: KH_2; pfam07650
1117942004513	pyridoxamine kinase; Validated; Region: PRK05756
1117942004514	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1117942004515	dimer interface [polypeptide binding]; other site
1117942004516	pyridoxal binding site [chemical binding]; other site
1117942004517	ATP binding site [chemical binding]; other site
1117942004518	Domain of unknown function DUF21; Region: DUF21; pfam01595
1117942004519	FOG: CBS domain [General function prediction only]; Region: COG0517
1117942004520	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1117942004521	Transporter associated domain; Region: CorC_HlyC; smart01091
1117942004522	metal-binding heat shock protein; Provisional; Region: PRK00016
1117942004523	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1117942004524	PhoH-like protein; Region: PhoH; pfam02562
1117942004525	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1117942004526	RNA methyltransferase, RsmE family; Region: TIGR00046
1117942004527	chaperone protein DnaJ; Provisional; Region: PRK14278
1117942004528	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117942004529	HSP70 interaction site [polypeptide binding]; other site
1117942004530	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1117942004531	Zn binding sites [ion binding]; other site
1117942004532	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1117942004533	dimer interface [polypeptide binding]; other site
1117942004534	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1117942004535	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1117942004536	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1117942004537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1117942004538	FeS/SAM binding site; other site
1117942004539	HemN C-terminal domain; Region: HemN_C; pfam06969
1117942004540	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1117942004541	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1117942004542	acyl-activating enzyme (AAE) consensus motif; other site
1117942004543	putative AMP binding site [chemical binding]; other site
1117942004544	putative active site [active]
1117942004545	putative CoA binding site [chemical binding]; other site
1117942004546	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1117942004547	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1117942004548	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1117942004549	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1117942004550	active site
1117942004551	Zn binding site [ion binding]; other site
1117942004552	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1117942004553	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1117942004554	substrate binding pocket [chemical binding]; other site
1117942004555	catalytic triad [active]
1117942004556	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1117942004557	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1117942004558	active site
1117942004559	metal binding site [ion binding]; metal-binding site
1117942004560	nudix motif; other site
1117942004561	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1117942004562	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1117942004563	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1117942004564	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1117942004565	active site
1117942004566	BCCT family transporter; Region: BCCT; pfam02028
1117942004567	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1117942004568	Predicted permeases [General function prediction only]; Region: COG0679
1117942004569	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1117942004570	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
1117942004571	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942004572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942004573	dimer interface [polypeptide binding]; other site
1117942004574	conserved gate region; other site
1117942004575	putative PBP binding loops; other site
1117942004576	ABC-ATPase subunit interface; other site
1117942004577	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1117942004578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942004579	dimer interface [polypeptide binding]; other site
1117942004580	conserved gate region; other site
1117942004581	putative PBP binding loops; other site
1117942004582	ABC-ATPase subunit interface; other site
1117942004583	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1117942004584	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942004585	Walker A/P-loop; other site
1117942004586	ATP binding site [chemical binding]; other site
1117942004587	Q-loop/lid; other site
1117942004588	ABC transporter signature motif; other site
1117942004589	Walker B; other site
1117942004590	D-loop; other site
1117942004591	H-loop/switch region; other site
1117942004592	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942004593	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942004594	Walker A/P-loop; other site
1117942004595	ATP binding site [chemical binding]; other site
1117942004596	Q-loop/lid; other site
1117942004597	ABC transporter signature motif; other site
1117942004598	Walker B; other site
1117942004599	D-loop; other site
1117942004600	H-loop/switch region; other site
1117942004601	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942004602	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1117942004603	Sulphur transport; Region: Sulf_transp; pfam04143
1117942004604	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1117942004605	CPxP  motif; other site
1117942004606	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942004607	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1117942004608	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1117942004609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1117942004610	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1117942004611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942004612	putative substrate translocation pore; other site
1117942004613	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942004614	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
1117942004615	Walker A/P-loop; other site
1117942004616	ATP binding site [chemical binding]; other site
1117942004617	Q-loop/lid; other site
1117942004618	ABC transporter signature motif; other site
1117942004619	Walker B; other site
1117942004620	D-loop; other site
1117942004621	H-loop/switch region; other site
1117942004622	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1117942004623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942004624	Walker A/P-loop; other site
1117942004625	ATP binding site [chemical binding]; other site
1117942004626	Q-loop/lid; other site
1117942004627	ABC transporter signature motif; other site
1117942004628	Walker B; other site
1117942004629	D-loop; other site
1117942004630	H-loop/switch region; other site
1117942004631	GTP-binding protein LepA; Provisional; Region: PRK05433
1117942004632	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1117942004633	G1 box; other site
1117942004634	putative GEF interaction site [polypeptide binding]; other site
1117942004635	GTP/Mg2+ binding site [chemical binding]; other site
1117942004636	Switch I region; other site
1117942004637	G2 box; other site
1117942004638	G3 box; other site
1117942004639	Switch II region; other site
1117942004640	G4 box; other site
1117942004641	G5 box; other site
1117942004642	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1117942004643	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1117942004644	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1117942004645	PemK-like protein; Region: PemK; pfam02452
1117942004646	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1117942004647	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1117942004648	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1117942004649	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1117942004650	hypothetical protein; Validated; Region: PRK05629
1117942004651	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1117942004652	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1117942004653	Competence protein; Region: Competence; pfam03772
1117942004654	comEA protein; Region: comE; TIGR01259
1117942004655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1117942004656	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1117942004657	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942004658	catalytic core [active]
1117942004659	Oligomerisation domain; Region: Oligomerisation; pfam02410
1117942004660	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1117942004661	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1117942004662	active site
1117942004663	(T/H)XGH motif; other site
1117942004664	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1117942004665	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1117942004666	putative catalytic cysteine [active]
1117942004667	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
1117942004668	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1117942004669	putative ligand binding site [chemical binding]; other site
1117942004670	putative NAD binding site [chemical binding]; other site
1117942004671	catalytic site [active]
1117942004672	Protein of unknown function (DUF454); Region: DUF454; cl01063
1117942004673	Predicted permease [General function prediction only]; Region: COG2985
1117942004674	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1117942004675	TrkA-C domain; Region: TrkA_C; pfam02080
1117942004676	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1117942004677	gamma-glutamyl kinase; Provisional; Region: PRK05429
1117942004678	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1117942004679	nucleotide binding site [chemical binding]; other site
1117942004680	homotetrameric interface [polypeptide binding]; other site
1117942004681	putative phosphate binding site [ion binding]; other site
1117942004682	putative allosteric binding site; other site
1117942004683	PUA domain; Region: PUA; pfam01472
1117942004684	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1117942004685	GTP1/OBG; Region: GTP1_OBG; pfam01018
1117942004686	Obg GTPase; Region: Obg; cd01898
1117942004687	G1 box; other site
1117942004688	GTP/Mg2+ binding site [chemical binding]; other site
1117942004689	Switch I region; other site
1117942004690	G2 box; other site
1117942004691	G3 box; other site
1117942004692	Switch II region; other site
1117942004693	G4 box; other site
1117942004694	G5 box; other site
1117942004695	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1117942004696	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1117942004697	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1117942004698	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1117942004699	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1117942004700	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1117942004701	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1117942004702	homodimer interface [polypeptide binding]; other site
1117942004703	oligonucleotide binding site [chemical binding]; other site
1117942004704	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1117942004705	active site
1117942004706	multimer interface [polypeptide binding]; other site
1117942004707	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1117942004708	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1117942004709	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1117942004710	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1117942004711	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117942004712	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1117942004713	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1117942004714	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1117942004715	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942004716	active site
1117942004717	HIGH motif; other site
1117942004718	nucleotide binding site [chemical binding]; other site
1117942004719	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1117942004720	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1117942004721	active site
1117942004722	KMSKS motif; other site
1117942004723	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1117942004724	tRNA binding surface [nucleotide binding]; other site
1117942004725	anticodon binding site; other site
1117942004726	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1117942004727	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1117942004728	malate dehydrogenase; Provisional; Region: PRK05442
1117942004729	NAD(P) binding site [chemical binding]; other site
1117942004730	dimer interface [polypeptide binding]; other site
1117942004731	malate binding site [chemical binding]; other site
1117942004732	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942004733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942004734	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1117942004735	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
1117942004736	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1117942004737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942004738	Walker A motif; other site
1117942004739	ATP binding site [chemical binding]; other site
1117942004740	Walker B motif; other site
1117942004741	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1117942004742	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1117942004743	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1117942004744	glutamine binding [chemical binding]; other site
1117942004745	catalytic triad [active]
1117942004746	hypothetical protein; Validated; Region: PRK09070
1117942004747	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1117942004748	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1117942004749	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1117942004750	substrate-cofactor binding pocket; other site
1117942004751	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1117942004752	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1117942004753	oligomer interface [polypeptide binding]; other site
1117942004754	active site residues [active]
1117942004755	Clp protease; Region: CLP_protease; pfam00574
1117942004756	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1117942004757	oligomer interface [polypeptide binding]; other site
1117942004758	active site residues [active]
1117942004759	trigger factor; Provisional; Region: tig; PRK01490
1117942004760	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1117942004761	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1117942004762	Pirin-related protein [General function prediction only]; Region: COG1741
1117942004763	Pirin; Region: Pirin; pfam02678
1117942004764	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1117942004765	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1117942004766	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1117942004767	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1117942004768	catalytic residues [active]
1117942004769	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1117942004770	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1117942004771	Zn binding site [ion binding]; other site
1117942004772	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1117942004773	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1117942004774	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1117942004775	apolar tunnel; other site
1117942004776	heme binding site [chemical binding]; other site
1117942004777	dimerization interface [polypeptide binding]; other site
1117942004778	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1117942004779	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1117942004780	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1117942004781	active site
1117942004782	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1117942004783	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1117942004784	dimer interface [polypeptide binding]; other site
1117942004785	ssDNA binding site [nucleotide binding]; other site
1117942004786	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1117942004787	YcaO-like family; Region: YcaO; pfam02624
1117942004788	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1117942004789	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1117942004790	FMN binding site [chemical binding]; other site
1117942004791	dimer interface [polypeptide binding]; other site
1117942004792	Nitroreductase family; Region: Nitroreductase; pfam00881
1117942004793	dimer interface [polypeptide binding]; other site
1117942004794	SpaB C-terminal domain; Region: SpaB_C; pfam14028
1117942004795	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1117942004796	YcaO-like family; Region: YcaO; pfam02624
1117942004797	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1117942004798	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1117942004799	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1117942004800	Walker A/P-loop; other site
1117942004801	ATP binding site [chemical binding]; other site
1117942004802	Q-loop/lid; other site
1117942004803	ABC transporter signature motif; other site
1117942004804	Walker B; other site
1117942004805	D-loop; other site
1117942004806	H-loop/switch region; other site
1117942004807	Copper resistance protein D; Region: CopD; pfam05425
1117942004808	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1117942004809	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1117942004810	Carbon starvation protein CstA; Region: CstA; pfam02554
1117942004811	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1117942004812	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1117942004813	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
1117942004814	active site
1117942004815	catalytic triad [active]
1117942004816	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1117942004817	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1117942004818	NADP binding site [chemical binding]; other site
1117942004819	dimer interface [polypeptide binding]; other site
1117942004820	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1117942004821	classical (c) SDRs; Region: SDR_c; cd05233
1117942004822	NAD(P) binding site [chemical binding]; other site
1117942004823	active site
1117942004824	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1117942004825	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1117942004826	catalytic site [active]
1117942004827	putative active site [active]
1117942004828	putative substrate binding site [chemical binding]; other site
1117942004829	dimer interface [polypeptide binding]; other site
1117942004830	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1117942004831	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1117942004832	inhibitor site; inhibition site
1117942004833	active site
1117942004834	dimer interface [polypeptide binding]; other site
1117942004835	catalytic residue [active]
1117942004836	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
1117942004837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1117942004838	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1117942004839	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1117942004840	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1117942004841	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1117942004842	NAD(P) binding site [chemical binding]; other site
1117942004843	substrate binding site [chemical binding]; other site
1117942004844	dimer interface [polypeptide binding]; other site
1117942004845	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1117942004846	Isochorismatase family; Region: Isochorismatase; pfam00857
1117942004847	catalytic triad [active]
1117942004848	metal binding site [ion binding]; metal-binding site
1117942004849	conserved cis-peptide bond; other site
1117942004850	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1117942004851	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1117942004852	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1117942004853	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1117942004854	catalytic triad [active]
1117942004855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942004856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942004857	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1117942004858	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1117942004859	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1117942004860	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1117942004861	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1117942004862	phosphate binding site [ion binding]; other site
1117942004863	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1117942004864	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1117942004865	active site 2 [active]
1117942004866	active site 1 [active]
1117942004867	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1117942004868	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1117942004869	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1117942004870	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1117942004871	putative NAD(P) binding site [chemical binding]; other site
1117942004872	active site
1117942004873	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1117942004874	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1117942004875	active site
1117942004876	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1117942004877	Histidine kinase; Region: HisKA_3; pfam07730
1117942004878	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1117942004879	Response regulator receiver domain; Region: Response_reg; pfam00072
1117942004880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942004881	active site
1117942004882	phosphorylation site [posttranslational modification]
1117942004883	intermolecular recognition site; other site
1117942004884	dimerization interface [polypeptide binding]; other site
1117942004885	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117942004886	DNA binding residues [nucleotide binding]
1117942004887	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1117942004888	CAAX protease self-immunity; Region: Abi; pfam02517
1117942004889	Glucitol operon activator protein (GutM); Region: GutM; cl01890
1117942004890	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1117942004891	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1117942004892	active site
1117942004893	dimerization interface [polypeptide binding]; other site
1117942004894	ribonuclease PH; Reviewed; Region: rph; PRK00173
1117942004895	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1117942004896	hexamer interface [polypeptide binding]; other site
1117942004897	active site
1117942004898	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1117942004899	glutamate racemase; Provisional; Region: PRK00865
1117942004900	Rhomboid family; Region: Rhomboid; pfam01694
1117942004901	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1117942004902	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1117942004903	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1117942004904	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1117942004905	active site
1117942004906	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1117942004907	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1117942004908	ATP binding site [chemical binding]; other site
1117942004909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1117942004910	putative Mg++ binding site [ion binding]; other site
1117942004911	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1117942004912	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1117942004913	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1117942004914	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1117942004915	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1117942004916	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1117942004917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942004918	motif II; other site
1117942004919	Winged helix-turn helix; Region: HTH_29; pfam13551
1117942004920	Helix-turn-helix domain; Region: HTH_28; pfam13518
1117942004921	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1117942004922	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1117942004923	D-pathway; other site
1117942004924	Putative ubiquinol binding site [chemical binding]; other site
1117942004925	Low-spin heme (heme b) binding site [chemical binding]; other site
1117942004926	Putative water exit pathway; other site
1117942004927	Binuclear center (heme o3/CuB) [ion binding]; other site
1117942004928	K-pathway; other site
1117942004929	Putative proton exit pathway; other site
1117942004930	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1117942004931	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1117942004932	dimer interface [polypeptide binding]; other site
1117942004933	putative radical transfer pathway; other site
1117942004934	diiron center [ion binding]; other site
1117942004935	tyrosyl radical; other site
1117942004936	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1117942004937	Ferritin-like domain; Region: Ferritin; pfam00210
1117942004938	ferroxidase diiron center [ion binding]; other site
1117942004939	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1117942004940	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1117942004941	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1117942004942	active site
1117942004943	dimer interface [polypeptide binding]; other site
1117942004944	catalytic residues [active]
1117942004945	effector binding site; other site
1117942004946	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1117942004947	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1117942004948	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1117942004949	catalytic residues [active]
1117942004950	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1117942004951	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1117942004952	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1117942004953	homodimer interface [polypeptide binding]; other site
1117942004954	NAD binding pocket [chemical binding]; other site
1117942004955	ATP binding pocket [chemical binding]; other site
1117942004956	Mg binding site [ion binding]; other site
1117942004957	active-site loop [active]
1117942004958	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1117942004959	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117942004960	dimerization interface [polypeptide binding]; other site
1117942004961	putative DNA binding site [nucleotide binding]; other site
1117942004962	putative Zn2+ binding site [ion binding]; other site
1117942004963	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
1117942004964	Thioredoxin; Region: Thioredoxin_4; cl17273
1117942004965	Predicted membrane protein [Function unknown]; Region: COG2259
1117942004966	phosphoglucomutase; Validated; Region: PRK07564
1117942004967	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1117942004968	active site
1117942004969	substrate binding site [chemical binding]; other site
1117942004970	metal binding site [ion binding]; metal-binding site
1117942004971	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
1117942004972	CrcB-like protein; Region: CRCB; pfam02537
1117942004973	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117942004974	FtsX-like permease family; Region: FtsX; pfam02687
1117942004975	FtsX-like permease family; Region: FtsX; pfam02687
1117942004976	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117942004977	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1117942004978	Walker A/P-loop; other site
1117942004979	ATP binding site [chemical binding]; other site
1117942004980	Q-loop/lid; other site
1117942004981	ABC transporter signature motif; other site
1117942004982	Walker B; other site
1117942004983	D-loop; other site
1117942004984	H-loop/switch region; other site
1117942004985	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1117942004986	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1117942004987	hinge; other site
1117942004988	active site
1117942004989	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1117942004990	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117942004991	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117942004992	DNA binding residues [nucleotide binding]
1117942004993	dimerization interface [polypeptide binding]; other site
1117942004994	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1117942004995	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1117942004996	dimer interface [polypeptide binding]; other site
1117942004997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942004998	catalytic residue [active]
1117942004999	serine O-acetyltransferase; Region: cysE; TIGR01172
1117942005000	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1117942005001	trimer interface [polypeptide binding]; other site
1117942005002	active site
1117942005003	substrate binding site [chemical binding]; other site
1117942005004	CoA binding site [chemical binding]; other site
1117942005005	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942005006	Coenzyme A binding pocket [chemical binding]; other site
1117942005007	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
1117942005008	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
1117942005009	putative active site [active]
1117942005010	metal binding site [ion binding]; metal-binding site
1117942005011	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1117942005012	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1117942005013	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1117942005014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1117942005015	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1117942005016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942005017	Walker A/P-loop; other site
1117942005018	ATP binding site [chemical binding]; other site
1117942005019	Q-loop/lid; other site
1117942005020	ABC transporter signature motif; other site
1117942005021	Walker B; other site
1117942005022	D-loop; other site
1117942005023	H-loop/switch region; other site
1117942005024	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1117942005025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942005026	Walker A/P-loop; other site
1117942005027	ATP binding site [chemical binding]; other site
1117942005028	Q-loop/lid; other site
1117942005029	ABC transporter signature motif; other site
1117942005030	Walker B; other site
1117942005031	D-loop; other site
1117942005032	H-loop/switch region; other site
1117942005033	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1117942005034	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1117942005035	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1117942005036	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1117942005037	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1117942005038	FMN binding site [chemical binding]; other site
1117942005039	active site
1117942005040	catalytic residues [active]
1117942005041	substrate binding site [chemical binding]; other site
1117942005042	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1117942005043	PhoU domain; Region: PhoU; pfam01895
1117942005044	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1117942005045	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1117942005046	Walker A/P-loop; other site
1117942005047	ATP binding site [chemical binding]; other site
1117942005048	Q-loop/lid; other site
1117942005049	ABC transporter signature motif; other site
1117942005050	Walker B; other site
1117942005051	D-loop; other site
1117942005052	H-loop/switch region; other site
1117942005053	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1117942005054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942005055	dimer interface [polypeptide binding]; other site
1117942005056	conserved gate region; other site
1117942005057	putative PBP binding loops; other site
1117942005058	ABC-ATPase subunit interface; other site
1117942005059	PBP superfamily domain; Region: PBP_like_2; cl17296
1117942005060	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1117942005061	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942005062	Coenzyme A binding pocket [chemical binding]; other site
1117942005063	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1117942005064	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1117942005065	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1117942005066	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1117942005067	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1117942005068	heme-binding site [chemical binding]; other site
1117942005069	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1117942005070	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1117942005071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942005072	catalytic residue [active]
1117942005073	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1117942005074	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1117942005075	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1117942005076	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1117942005077	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1117942005078	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1117942005079	dimerization interface [polypeptide binding]; other site
1117942005080	putative ATP binding site [chemical binding]; other site
1117942005081	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1117942005082	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1117942005083	active site
1117942005084	tetramer interface [polypeptide binding]; other site
1117942005085	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942005086	active site
1117942005087	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1117942005088	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1117942005089	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1117942005090	dimer interface [polypeptide binding]; other site
1117942005091	putative radical transfer pathway; other site
1117942005092	diiron center [ion binding]; other site
1117942005093	tyrosyl radical; other site
1117942005094	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1117942005095	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1117942005096	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1117942005097	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1117942005098	dimerization interface [polypeptide binding]; other site
1117942005099	ATP binding site [chemical binding]; other site
1117942005100	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1117942005101	dimerization interface [polypeptide binding]; other site
1117942005102	ATP binding site [chemical binding]; other site
1117942005103	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1117942005104	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1117942005105	putative active site [active]
1117942005106	catalytic triad [active]
1117942005107	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1117942005108	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1117942005109	catalytic residues [active]
1117942005110	dimer interface [polypeptide binding]; other site
1117942005111	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1117942005112	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1117942005113	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1117942005114	ATP binding site [chemical binding]; other site
1117942005115	active site
1117942005116	substrate binding site [chemical binding]; other site
1117942005117	adenylosuccinate lyase; Region: purB; TIGR00928
1117942005118	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1117942005119	tetramer interface [polypeptide binding]; other site
1117942005120	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1117942005121	TrkA-N domain; Region: TrkA_N; pfam02254
1117942005122	TrkA-C domain; Region: TrkA_C; pfam02080
1117942005123	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1117942005124	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1117942005125	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1117942005126	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1117942005127	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1117942005128	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1117942005129	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1117942005130	nucleotide binding site/active site [active]
1117942005131	HIT family signature motif; other site
1117942005132	catalytic residue [active]
1117942005133	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1117942005134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1117942005135	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1117942005136	dimerization interface [polypeptide binding]; other site
1117942005137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1117942005138	dimer interface [polypeptide binding]; other site
1117942005139	phosphorylation site [posttranslational modification]
1117942005140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1117942005141	ATP binding site [chemical binding]; other site
1117942005142	Mg2+ binding site [ion binding]; other site
1117942005143	G-X-G motif; other site
1117942005144	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1117942005145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942005146	active site
1117942005147	phosphorylation site [posttranslational modification]
1117942005148	intermolecular recognition site; other site
1117942005149	dimerization interface [polypeptide binding]; other site
1117942005150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1117942005151	DNA binding site [nucleotide binding]
1117942005152	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942005153	Predicted esterase [General function prediction only]; Region: COG0627
1117942005154	S-formylglutathione hydrolase; Region: PLN02442
1117942005155	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1117942005156	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1117942005157	putative active site [active]
1117942005158	pyruvate dehydrogenase; Provisional; Region: PRK06546
1117942005159	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1117942005160	PYR/PP interface [polypeptide binding]; other site
1117942005161	tetramer interface [polypeptide binding]; other site
1117942005162	dimer interface [polypeptide binding]; other site
1117942005163	TPP binding site [chemical binding]; other site
1117942005164	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1117942005165	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1117942005166	TPP-binding site [chemical binding]; other site
1117942005167	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1117942005168	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1117942005169	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1117942005170	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1117942005171	active site
1117942005172	homotetramer interface [polypeptide binding]; other site
1117942005173	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1117942005174	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1117942005175	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1117942005176	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1117942005177	DNA binding site [nucleotide binding]
1117942005178	domain linker motif; other site
1117942005179	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
1117942005180	putative dimerization interface [polypeptide binding]; other site
1117942005181	putative ligand binding site [chemical binding]; other site
1117942005182	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1117942005183	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1117942005184	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1117942005185	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117942005186	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1117942005187	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942005188	active site
1117942005189	HIGH motif; other site
1117942005190	nucleotide binding site [chemical binding]; other site
1117942005191	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1117942005192	KMSKS motif; other site
1117942005193	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1117942005194	tRNA binding surface [nucleotide binding]; other site
1117942005195	anticodon binding site; other site
1117942005196	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1117942005197	homotrimer interaction site [polypeptide binding]; other site
1117942005198	zinc binding site [ion binding]; other site
1117942005199	CDP-binding sites; other site
1117942005200	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1117942005201	substrate binding site; other site
1117942005202	dimer interface; other site
1117942005203	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1117942005204	DNA repair protein RadA; Provisional; Region: PRK11823
1117942005205	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1117942005206	Walker A motif; other site
1117942005207	ATP binding site [chemical binding]; other site
1117942005208	Walker B motif; other site
1117942005209	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1117942005210	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1117942005211	active site clefts [active]
1117942005212	zinc binding site [ion binding]; other site
1117942005213	dimer interface [polypeptide binding]; other site
1117942005214	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1117942005215	endonuclease III; Region: ENDO3c; smart00478
1117942005216	minor groove reading motif; other site
1117942005217	helix-hairpin-helix signature motif; other site
1117942005218	substrate binding pocket [chemical binding]; other site
1117942005219	active site
1117942005220	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1117942005221	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1117942005222	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1117942005223	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
1117942005224	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1117942005225	Clp amino terminal domain; Region: Clp_N; pfam02861
1117942005226	Clp amino terminal domain; Region: Clp_N; pfam02861
1117942005227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942005228	Walker A motif; other site
1117942005229	ATP binding site [chemical binding]; other site
1117942005230	Walker B motif; other site
1117942005231	arginine finger; other site
1117942005232	UvrB/uvrC motif; Region: UVR; pfam02151
1117942005233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942005234	Walker A motif; other site
1117942005235	ATP binding site [chemical binding]; other site
1117942005236	Walker B motif; other site
1117942005237	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1117942005238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942005239	putative substrate translocation pore; other site
1117942005240	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1117942005241	active site
1117942005242	tetramer interface [polypeptide binding]; other site
1117942005243	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1117942005244	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1117942005245	CAAX protease self-immunity; Region: Abi; pfam02517
1117942005246	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1117942005247	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1117942005248	dimer interface [polypeptide binding]; other site
1117942005249	putative anticodon binding site; other site
1117942005250	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117942005251	motif 1; other site
1117942005252	dimer interface [polypeptide binding]; other site
1117942005253	active site
1117942005254	motif 2; other site
1117942005255	motif 3; other site
1117942005256	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1117942005257	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1117942005258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1117942005259	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117942005260	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1117942005261	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1117942005262	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117942005263	NAD(P) binding site [chemical binding]; other site
1117942005264	catalytic residues [active]
1117942005265	choline dehydrogenase; Validated; Region: PRK02106
1117942005266	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1117942005267	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1117942005268	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942005269	active site
1117942005270	nucleotide binding site [chemical binding]; other site
1117942005271	HIGH motif; other site
1117942005272	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942005273	KMSKS motif; other site
1117942005274	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1117942005275	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1117942005276	catalytic center binding site [active]
1117942005277	ATP binding site [chemical binding]; other site
1117942005278	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1117942005279	homooctamer interface [polypeptide binding]; other site
1117942005280	active site
1117942005281	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1117942005282	dihydropteroate synthase; Region: DHPS; TIGR01496
1117942005283	substrate binding pocket [chemical binding]; other site
1117942005284	dimer interface [polypeptide binding]; other site
1117942005285	inhibitor binding site; inhibition site
1117942005286	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1117942005287	GTP cyclohydrolase I; Provisional; Region: PLN03044
1117942005288	homodecamer interface [polypeptide binding]; other site
1117942005289	active site
1117942005290	putative catalytic site residues [active]
1117942005291	zinc binding site [ion binding]; other site
1117942005292	GTP-CH-I/GFRP interaction surface; other site
1117942005293	FtsH Extracellular; Region: FtsH_ext; pfam06480
1117942005294	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1117942005295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942005296	Walker A motif; other site
1117942005297	ATP binding site [chemical binding]; other site
1117942005298	Walker B motif; other site
1117942005299	arginine finger; other site
1117942005300	Peptidase family M41; Region: Peptidase_M41; pfam01434
1117942005301	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942005302	active site
1117942005303	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1117942005304	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1117942005305	Ligand Binding Site [chemical binding]; other site
1117942005306	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1117942005307	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1117942005308	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1117942005309	dimer interface [polypeptide binding]; other site
1117942005310	substrate binding site [chemical binding]; other site
1117942005311	metal binding sites [ion binding]; metal-binding site
1117942005312	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1117942005313	active site residue [active]
1117942005314	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1117942005315	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117942005316	Secretory lipase; Region: LIP; pfam03583
1117942005317	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1117942005318	MarR family; Region: MarR_2; pfam12802
1117942005319	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1117942005320	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1117942005321	acyl-activating enzyme (AAE) consensus motif; other site
1117942005322	AMP binding site [chemical binding]; other site
1117942005323	active site
1117942005324	CoA binding site [chemical binding]; other site
1117942005325	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1117942005326	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1117942005327	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117942005328	putative trimer interface [polypeptide binding]; other site
1117942005329	putative CoA binding site [chemical binding]; other site
1117942005330	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1117942005331	putative trimer interface [polypeptide binding]; other site
1117942005332	putative CoA binding site [chemical binding]; other site
1117942005333	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1117942005334	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1117942005335	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1117942005336	ring oligomerisation interface [polypeptide binding]; other site
1117942005337	ATP/Mg binding site [chemical binding]; other site
1117942005338	stacking interactions; other site
1117942005339	hinge regions; other site
1117942005340	hypothetical protein; Provisional; Region: PRK07907
1117942005341	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1117942005342	active site
1117942005343	metal binding site [ion binding]; metal-binding site
1117942005344	dimer interface [polypeptide binding]; other site
1117942005345	potential frameshift: common BLAST hit: gi|376289391|ref|YP_005161638.1| putative surface-anchored fimbrial subunit
1117942005346	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1117942005347	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1117942005348	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1117942005349	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1117942005350	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1117942005351	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1117942005352	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1117942005353	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1117942005354	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1117942005355	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
1117942005356	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
1117942005357	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1117942005358	carboxylate-amine ligase; Provisional; Region: PRK13517
1117942005359	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1117942005360	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1117942005361	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1117942005362	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1117942005363	active site
1117942005364	catalytic residues [active]
1117942005365	metal binding site [ion binding]; metal-binding site
1117942005366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1117942005367	Coenzyme A binding pocket [chemical binding]; other site
1117942005368	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1117942005369	putative catalytic site [active]
1117942005370	putative phosphate binding site [ion binding]; other site
1117942005371	active site
1117942005372	metal binding site A [ion binding]; metal-binding site
1117942005373	DNA binding site [nucleotide binding]
1117942005374	putative AP binding site [nucleotide binding]; other site
1117942005375	putative metal binding site B [ion binding]; other site
1117942005376	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1117942005377	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1117942005378	putative active site [active]
1117942005379	catalytic site [active]
1117942005380	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1117942005381	putative active site [active]
1117942005382	catalytic site [active]
1117942005383	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1117942005384	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1117942005385	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1117942005386	Walker A/P-loop; other site
1117942005387	ATP binding site [chemical binding]; other site
1117942005388	Q-loop/lid; other site
1117942005389	ABC transporter signature motif; other site
1117942005390	Walker B; other site
1117942005391	D-loop; other site
1117942005392	H-loop/switch region; other site
1117942005393	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1117942005394	nudix motif; other site
1117942005395	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1117942005396	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1117942005397	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1117942005398	substrate binding pocket [chemical binding]; other site
1117942005399	membrane-bound complex binding site; other site
1117942005400	hinge residues; other site
1117942005401	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1117942005402	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1117942005403	active site
1117942005404	ATP binding site [chemical binding]; other site
1117942005405	substrate binding site [chemical binding]; other site
1117942005406	activation loop (A-loop); other site
1117942005407	propionate/acetate kinase; Provisional; Region: PRK12379
1117942005408	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1117942005409	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1117942005410	ferredoxin-NADP+ reductase; Region: PLN02852
1117942005411	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117942005412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1117942005413	Coenzyme A binding pocket [chemical binding]; other site
1117942005414	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1117942005415	active site
1117942005416	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1117942005417	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1117942005418	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942005419	active site
1117942005420	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1117942005421	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1117942005422	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1117942005423	catalytic residues [active]
1117942005424	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1117942005425	ResB-like family; Region: ResB; pfam05140
1117942005426	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1117942005427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1117942005428	TPR motif; other site
1117942005429	TPR repeat; Region: TPR_11; pfam13414
1117942005430	binding surface
1117942005431	Cytochrome c552; Region: Cytochrom_C552; pfam02335
1117942005432	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1117942005433	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
1117942005434	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1117942005435	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1117942005436	GDP-binding site [chemical binding]; other site
1117942005437	ACT binding site; other site
1117942005438	IMP binding site; other site
1117942005439	Predicted membrane protein [Function unknown]; Region: COG4129
1117942005440	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1117942005441	Predicted membrane protein [Function unknown]; Region: COG4129
1117942005442	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1117942005443	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1117942005444	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1117942005445	Walker A/P-loop; other site
1117942005446	ATP binding site [chemical binding]; other site
1117942005447	Q-loop/lid; other site
1117942005448	ABC transporter signature motif; other site
1117942005449	Walker B; other site
1117942005450	D-loop; other site
1117942005451	H-loop/switch region; other site
1117942005452	Predicted transcriptional regulators [Transcription]; Region: COG1695
1117942005453	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1117942005454	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1117942005455	Cna protein B-type domain; Region: Cna_B; pfam05738
1117942005456	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
1117942005457	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
1117942005458	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1117942005459	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1117942005460	active site
1117942005461	intersubunit interface [polypeptide binding]; other site
1117942005462	zinc binding site [ion binding]; other site
1117942005463	Na+ binding site [ion binding]; other site
1117942005464	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
1117942005465	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1117942005466	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1117942005467	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1117942005468	active site
1117942005469	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1117942005470	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1117942005471	active site residue [active]
1117942005472	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1117942005473	active site residue [active]
1117942005474	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1117942005475	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1117942005476	Gram positive anchor; Region: Gram_pos_anchor; cl15427
1117942005477	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1117942005478	active site
1117942005479	catalytic site [active]
1117942005480	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1117942005481	Cna protein B-type domain; Region: Cna_B; pfam05738
1117942005482	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1117942005483	active site
1117942005484	catalytic site [active]
1117942005485	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1117942005486	Clp amino terminal domain; Region: Clp_N; pfam02861
1117942005487	Clp amino terminal domain; Region: Clp_N; pfam02861
1117942005488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942005489	Walker A motif; other site
1117942005490	ATP binding site [chemical binding]; other site
1117942005491	Walker B motif; other site
1117942005492	arginine finger; other site
1117942005493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1117942005494	Walker A motif; other site
1117942005495	ATP binding site [chemical binding]; other site
1117942005496	Walker B motif; other site
1117942005497	arginine finger; other site
1117942005498	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1117942005499	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1117942005500	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1117942005501	Walker A/P-loop; other site
1117942005502	ATP binding site [chemical binding]; other site
1117942005503	Q-loop/lid; other site
1117942005504	ABC transporter signature motif; other site
1117942005505	Walker B; other site
1117942005506	D-loop; other site
1117942005507	H-loop/switch region; other site
1117942005508	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1117942005509	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1117942005510	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1117942005511	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1117942005512	FAD binding pocket [chemical binding]; other site
1117942005513	conserved FAD binding motif [chemical binding]; other site
1117942005514	phosphate binding motif [ion binding]; other site
1117942005515	beta-alpha-beta structure motif; other site
1117942005516	NAD binding pocket [chemical binding]; other site
1117942005517	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117942005518	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1117942005519	FtsX-like permease family; Region: FtsX; pfam02687
1117942005520	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1117942005521	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117942005522	Walker A/P-loop; other site
1117942005523	ATP binding site [chemical binding]; other site
1117942005524	Q-loop/lid; other site
1117942005525	ABC transporter signature motif; other site
1117942005526	Walker B; other site
1117942005527	D-loop; other site
1117942005528	H-loop/switch region; other site
1117942005529	HlyD family secretion protein; Region: HlyD_3; pfam13437
1117942005530	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1117942005531	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1117942005532	putative active site [active]
1117942005533	catalytic triad [active]
1117942005534	putative dimer interface [polypeptide binding]; other site
1117942005535	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1117942005536	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1117942005537	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1117942005538	NAD binding site [chemical binding]; other site
1117942005539	substrate binding site [chemical binding]; other site
1117942005540	catalytic Zn binding site [ion binding]; other site
1117942005541	tetramer interface [polypeptide binding]; other site
1117942005542	structural Zn binding site [ion binding]; other site
1117942005543	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
1117942005544	active site
1117942005545	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1117942005546	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1117942005547	DNA binding residues [nucleotide binding]
1117942005548	chaperone protein DnaJ; Provisional; Region: PRK14279
1117942005549	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1117942005550	HSP70 interaction site [polypeptide binding]; other site
1117942005551	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1117942005552	Zn binding sites [ion binding]; other site
1117942005553	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1117942005554	dimer interface [polypeptide binding]; other site
1117942005555	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1117942005556	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1117942005557	dimer interface [polypeptide binding]; other site
1117942005558	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1117942005559	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1117942005560	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1117942005561	nucleotide binding site [chemical binding]; other site
1117942005562	NEF interaction site [polypeptide binding]; other site
1117942005563	SBD interface [polypeptide binding]; other site
1117942005564	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1117942005565	active site
1117942005566	catalytic site [active]
1117942005567	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1117942005568	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1117942005569	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942005570	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
1117942005571	Walker A/P-loop; other site
1117942005572	ATP binding site [chemical binding]; other site
1117942005573	Q-loop/lid; other site
1117942005574	ABC transporter signature motif; other site
1117942005575	Walker B; other site
1117942005576	D-loop; other site
1117942005577	H-loop/switch region; other site
1117942005578	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1117942005579	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942005580	putative PBP binding loops; other site
1117942005581	dimer interface [polypeptide binding]; other site
1117942005582	ABC-ATPase subunit interface; other site
1117942005583	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942005584	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1117942005585	Walker A/P-loop; other site
1117942005586	ATP binding site [chemical binding]; other site
1117942005587	Q-loop/lid; other site
1117942005588	ABC transporter signature motif; other site
1117942005589	Walker B; other site
1117942005590	D-loop; other site
1117942005591	H-loop/switch region; other site
1117942005592	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942005593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942005594	dimer interface [polypeptide binding]; other site
1117942005595	conserved gate region; other site
1117942005596	putative PBP binding loops; other site
1117942005597	ABC-ATPase subunit interface; other site
1117942005598	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1117942005599	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1117942005600	adrenodoxin reductase; Provisional; Region: PTZ00188
1117942005601	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1117942005602	4Fe-4S binding domain; Region: Fer4; cl02805
1117942005603	4Fe-4S binding domain; Region: Fer4; pfam00037
1117942005604	Cysteine-rich domain; Region: CCG; pfam02754
1117942005605	Cysteine-rich domain; Region: CCG; pfam02754
1117942005606	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1117942005607	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1117942005608	dimerization interface [polypeptide binding]; other site
1117942005609	putative DNA binding site [nucleotide binding]; other site
1117942005610	putative Zn2+ binding site [ion binding]; other site
1117942005611	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1117942005612	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942005613	Walker A/P-loop; other site
1117942005614	ATP binding site [chemical binding]; other site
1117942005615	Q-loop/lid; other site
1117942005616	ABC transporter signature motif; other site
1117942005617	Walker B; other site
1117942005618	D-loop; other site
1117942005619	H-loop/switch region; other site
1117942005620	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1117942005621	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942005622	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942005623	putative PBP binding regions; other site
1117942005624	ABC-ATPase subunit  interface; other site
1117942005625	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1117942005626	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1117942005627	intersubunit interface [polypeptide binding]; other site
1117942005628	UreD urease accessory protein; Region: UreD; cl00530
1117942005629	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1117942005630	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1117942005631	UreF; Region: UreF; pfam01730
1117942005632	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1117942005633	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1117942005634	dimer interface [polypeptide binding]; other site
1117942005635	catalytic residues [active]
1117942005636	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1117942005637	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1117942005638	subunit interactions [polypeptide binding]; other site
1117942005639	active site
1117942005640	flap region; other site
1117942005641	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1117942005642	gamma-beta subunit interface [polypeptide binding]; other site
1117942005643	alpha-beta subunit interface [polypeptide binding]; other site
1117942005644	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1117942005645	alpha-gamma subunit interface [polypeptide binding]; other site
1117942005646	beta-gamma subunit interface [polypeptide binding]; other site
1117942005647	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1117942005648	EamA-like transporter family; Region: EamA; pfam00892
1117942005649	EamA-like transporter family; Region: EamA; pfam00892
1117942005650	aminotransferase AlaT; Validated; Region: PRK09265
1117942005651	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1117942005652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942005653	homodimer interface [polypeptide binding]; other site
1117942005654	catalytic residue [active]
1117942005655	YibE/F-like protein; Region: YibE_F; pfam07907
1117942005656	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
1117942005657	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1117942005658	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1117942005659	dimer interface [polypeptide binding]; other site
1117942005660	putative anticodon binding site; other site
1117942005661	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1117942005662	motif 1; other site
1117942005663	dimer interface [polypeptide binding]; other site
1117942005664	active site
1117942005665	motif 2; other site
1117942005666	motif 3; other site
1117942005667	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1117942005668	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1117942005669	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1117942005670	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1117942005671	trimer interface [polypeptide binding]; other site
1117942005672	active site
1117942005673	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1117942005674	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1117942005675	NAD(P) binding site [chemical binding]; other site
1117942005676	catalytic residues [active]
1117942005677	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
1117942005678	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1117942005679	VanW like protein; Region: VanW; pfam04294
1117942005680	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1117942005681	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1117942005682	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
1117942005683	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1117942005684	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1117942005685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1117942005686	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1117942005687	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1117942005688	active site
1117942005689	substrate-binding site [chemical binding]; other site
1117942005690	metal-binding site [ion binding]
1117942005691	GTP binding site [chemical binding]; other site
1117942005692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1117942005693	S-adenosylmethionine binding site [chemical binding]; other site
1117942005694	LabA_like proteins; Region: LabA_like; cd06167
1117942005695	putative metal binding site [ion binding]; other site
1117942005696	MMPL family; Region: MMPL; pfam03176
1117942005697	MMPL family; Region: MMPL; pfam03176
1117942005698	Predicted integral membrane protein [Function unknown]; Region: COG0392
1117942005699	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1117942005700	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1117942005701	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1117942005702	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1117942005703	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1117942005704	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
1117942005705	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1117942005706	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1117942005707	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1117942005708	active site
1117942005709	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1117942005710	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1117942005711	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1117942005712	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1117942005713	acyl-activating enzyme (AAE) consensus motif; other site
1117942005714	active site
1117942005715	Cutinase; Region: Cutinase; pfam01083
1117942005716	Putative esterase; Region: Esterase; pfam00756
1117942005717	S-formylglutathione hydrolase; Region: PLN02442
1117942005718	LGFP repeat; Region: LGFP; pfam08310
1117942005719	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1117942005720	LGFP repeat; Region: LGFP; pfam08310
1117942005721	LGFP repeat; Region: LGFP; pfam08310
1117942005722	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1117942005723	Predicted esterase [General function prediction only]; Region: COG0627
1117942005724	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1117942005725	UbiA prenyltransferase family; Region: UbiA; pfam01040
1117942005726	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1117942005727	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1117942005728	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1117942005729	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1117942005730	Repair protein; Region: Repair_PSII; pfam04536
1117942005731	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1117942005732	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1117942005733	active site
1117942005734	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
1117942005735	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1117942005736	active site
1117942005737	catalytic site [active]
1117942005738	metal binding site [ion binding]; metal-binding site
1117942005739	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1117942005740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942005741	putative substrate translocation pore; other site
1117942005742	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1117942005743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117942005744	UDP-galactopyranose mutase; Region: GLF; pfam03275
1117942005745	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1117942005746	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1117942005747	Walker A/P-loop; other site
1117942005748	ATP binding site [chemical binding]; other site
1117942005749	Q-loop/lid; other site
1117942005750	ABC transporter signature motif; other site
1117942005751	Walker B; other site
1117942005752	D-loop; other site
1117942005753	H-loop/switch region; other site
1117942005754	FecCD transport family; Region: FecCD; pfam01032
1117942005755	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1117942005756	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1117942005757	putative PBP binding regions; other site
1117942005758	ABC-ATPase subunit  interface; other site
1117942005759	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1117942005760	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1117942005761	putative binding site residues; other site
1117942005762	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1117942005763	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1117942005764	amidase catalytic site [active]
1117942005765	Zn binding residues [ion binding]; other site
1117942005766	substrate binding site [chemical binding]; other site
1117942005767	LGFP repeat; Region: LGFP; pfam08310
1117942005768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942005769	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1117942005770	active site
1117942005771	motif I; other site
1117942005772	motif II; other site
1117942005773	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1117942005774	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1117942005775	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1117942005776	putative acyl-acceptor binding pocket; other site
1117942005777	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1117942005778	seryl-tRNA synthetase; Provisional; Region: PRK05431
1117942005779	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1117942005780	dimer interface [polypeptide binding]; other site
1117942005781	active site
1117942005782	motif 1; other site
1117942005783	motif 2; other site
1117942005784	motif 3; other site
1117942005785	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1117942005786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117942005787	DNA-binding site [nucleotide binding]; DNA binding site
1117942005788	UTRA domain; Region: UTRA; pfam07702
1117942005789	Septum formation; Region: Septum_form; pfam13845
1117942005790	Septum formation; Region: Septum_form; pfam13845
1117942005791	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1117942005792	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1117942005793	catalytic core [active]
1117942005794	Prephenate dehydratase; Region: PDT; pfam00800
1117942005795	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1117942005796	putative L-Phe binding site [chemical binding]; other site
1117942005797	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1117942005798	Amidase; Region: Amidase; cl11426
1117942005799	CAAX protease self-immunity; Region: Abi; pfam02517
1117942005800	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1117942005801	Htaa; Region: HtaA; pfam04213
1117942005802	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1117942005803	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1117942005804	putative active site [active]
1117942005805	catalytic site [active]
1117942005806	putative metal binding site [ion binding]; other site
1117942005807	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1117942005808	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1117942005809	Nucleoside recognition; Region: Gate; pfam07670
1117942005810	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1117942005811	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1117942005812	active site
1117942005813	catalytic motif [active]
1117942005814	Zn binding site [ion binding]; other site
1117942005815	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1117942005816	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1117942005817	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1117942005818	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1117942005819	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1117942005820	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1117942005821	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1117942005822	NAD binding site [chemical binding]; other site
1117942005823	dimer interface [polypeptide binding]; other site
1117942005824	substrate binding site [chemical binding]; other site
1117942005825	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1117942005826	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1117942005827	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1117942005828	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1117942005829	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1117942005830	Predicted flavoprotein [General function prediction only]; Region: COG0431
1117942005831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942005832	putative substrate translocation pore; other site
1117942005833	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1117942005834	Abi-like protein; Region: Abi_2; pfam07751
1117942005835	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1117942005836	homodimer interface [polypeptide binding]; other site
1117942005837	chemical substrate binding site [chemical binding]; other site
1117942005838	oligomer interface [polypeptide binding]; other site
1117942005839	metal binding site [ion binding]; metal-binding site
1117942005840	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1117942005841	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1117942005842	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1117942005843	Lsr2; Region: Lsr2; pfam11774
1117942005844	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117942005845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942005846	active site
1117942005847	phosphorylation site [posttranslational modification]
1117942005848	intermolecular recognition site; other site
1117942005849	dimerization interface [polypeptide binding]; other site
1117942005850	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117942005851	DNA binding residues [nucleotide binding]
1117942005852	dimerization interface [polypeptide binding]; other site
1117942005853	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
1117942005854	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
1117942005855	active site
1117942005856	catalytic site [active]
1117942005857	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
1117942005858	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1117942005859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1117942005860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1117942005861	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1117942005862	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117942005863	Ligand Binding Site [chemical binding]; other site
1117942005864	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117942005865	Ligand Binding Site [chemical binding]; other site
1117942005866	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1117942005867	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1117942005868	active site
1117942005869	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1117942005870	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1117942005871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1117942005872	Walker A/P-loop; other site
1117942005873	ATP binding site [chemical binding]; other site
1117942005874	Q-loop/lid; other site
1117942005875	ABC transporter signature motif; other site
1117942005876	Walker B; other site
1117942005877	D-loop; other site
1117942005878	H-loop/switch region; other site
1117942005879	Predicted transcriptional regulators [Transcription]; Region: COG1725
1117942005880	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117942005881	DNA-binding site [nucleotide binding]; DNA binding site
1117942005882	LabA_like proteins; Region: LabA_like; cd06167
1117942005883	putative metal binding site [ion binding]; other site
1117942005884	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1117942005885	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1117942005886	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1117942005887	catalytic residues [active]
1117942005888	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1117942005889	metal-binding site [ion binding]
1117942005890	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1117942005891	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1117942005892	metal-binding site [ion binding]
1117942005893	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1117942005894	benzoate transport; Region: 2A0115; TIGR00895
1117942005895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942005896	putative substrate translocation pore; other site
1117942005897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1117942005898	replicative DNA helicase; Provisional; Region: PRK05636
1117942005899	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1117942005900	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1117942005901	Walker A motif; other site
1117942005902	ATP binding site [chemical binding]; other site
1117942005903	Walker B motif; other site
1117942005904	DNA binding loops [nucleotide binding]
1117942005905	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1117942005906	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1117942005907	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1117942005908	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1117942005909	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1117942005910	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1117942005911	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1117942005912	dimer interface [polypeptide binding]; other site
1117942005913	ssDNA binding site [nucleotide binding]; other site
1117942005914	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1117942005915	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1117942005916	Predicted integral membrane protein [Function unknown]; Region: COG5650
1117942005917	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1117942005918	Transglycosylase; Region: Transgly; pfam00912
1117942005919	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1117942005920	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1117942005921	MarR family; Region: MarR; pfam01047
1117942005922	MarR family; Region: MarR_2; cl17246
1117942005923	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117942005924	Ligand Binding Site [chemical binding]; other site
1117942005925	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1117942005926	Ligand Binding Site [chemical binding]; other site
1117942005927	short chain dehydrogenase; Provisional; Region: PRK08219
1117942005928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1117942005929	NAD(P) binding site [chemical binding]; other site
1117942005930	active site
1117942005931	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1117942005932	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1117942005933	active site residue [active]
1117942005934	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1117942005935	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1117942005936	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1117942005937	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1117942005938	dimerization interface [polypeptide binding]; other site
1117942005939	DPS ferroxidase diiron center [ion binding]; other site
1117942005940	ion pore; other site
1117942005941	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1117942005942	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1117942005943	putative DNA binding site [nucleotide binding]; other site
1117942005944	catalytic residue [active]
1117942005945	putative H2TH interface [polypeptide binding]; other site
1117942005946	putative catalytic residues [active]
1117942005947	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1117942005948	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1117942005949	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
1117942005950	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1117942005951	putative substrate binding site [chemical binding]; other site
1117942005952	putative ATP binding site [chemical binding]; other site
1117942005953	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
1117942005954	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1117942005955	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1117942005956	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1117942005957	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1117942005958	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1117942005959	HIGH motif; other site
1117942005960	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1117942005961	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942005962	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1117942005963	active site
1117942005964	KMSKS motif; other site
1117942005965	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1117942005966	tRNA binding surface [nucleotide binding]; other site
1117942005967	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1117942005968	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1117942005969	Walker A/P-loop; other site
1117942005970	ATP binding site [chemical binding]; other site
1117942005971	Q-loop/lid; other site
1117942005972	ABC transporter signature motif; other site
1117942005973	Walker B; other site
1117942005974	D-loop; other site
1117942005975	H-loop/switch region; other site
1117942005976	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1117942005977	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1117942005978	FtsX-like permease family; Region: FtsX; pfam02687
1117942005979	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1117942005980	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
1117942005981	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1117942005982	Histidine kinase; Region: HisKA_3; pfam07730
1117942005983	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1117942005984	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1117942005985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1117942005986	active site
1117942005987	phosphorylation site [posttranslational modification]
1117942005988	intermolecular recognition site; other site
1117942005989	dimerization interface [polypeptide binding]; other site
1117942005990	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1117942005991	DNA binding residues [nucleotide binding]
1117942005992	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1117942005993	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1117942005994	active site
1117942005995	trimer interface [polypeptide binding]; other site
1117942005996	allosteric site; other site
1117942005997	active site lid [active]
1117942005998	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1117942005999	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1117942006000	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1117942006001	active site
1117942006002	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1117942006003	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1117942006004	putative active site cavity [active]
1117942006005	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1117942006006	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1117942006007	nucleotide binding site [chemical binding]; other site
1117942006008	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1117942006009	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1117942006010	DNA-binding site [nucleotide binding]; DNA binding site
1117942006011	FCD domain; Region: FCD; pfam07729
1117942006012	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1117942006013	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1117942006014	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1117942006015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942006016	dimer interface [polypeptide binding]; other site
1117942006017	conserved gate region; other site
1117942006018	putative PBP binding loops; other site
1117942006019	ABC-ATPase subunit interface; other site
1117942006020	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1117942006021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1117942006022	dimer interface [polypeptide binding]; other site
1117942006023	conserved gate region; other site
1117942006024	putative PBP binding loops; other site
1117942006025	ABC-ATPase subunit interface; other site
1117942006026	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1117942006027	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942006028	Walker A/P-loop; other site
1117942006029	ATP binding site [chemical binding]; other site
1117942006030	Q-loop/lid; other site
1117942006031	ABC transporter signature motif; other site
1117942006032	Walker B; other site
1117942006033	D-loop; other site
1117942006034	H-loop/switch region; other site
1117942006035	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1117942006036	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1117942006037	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1117942006038	Walker A/P-loop; other site
1117942006039	ATP binding site [chemical binding]; other site
1117942006040	Q-loop/lid; other site
1117942006041	ABC transporter signature motif; other site
1117942006042	Walker B; other site
1117942006043	D-loop; other site
1117942006044	H-loop/switch region; other site
1117942006045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1117942006046	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1117942006047	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1117942006048	inhibitor site; inhibition site
1117942006049	active site
1117942006050	dimer interface [polypeptide binding]; other site
1117942006051	catalytic residue [active]
1117942006052	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1117942006053	active site
1117942006054	catalytic residues [active]
1117942006055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1117942006056	hypothetical protein; Provisional; Region: PRK13663
1117942006057	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
1117942006058	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
1117942006059	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1117942006060	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1117942006061	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1117942006062	phytoene desaturase; Region: crtI_fam; TIGR02734
1117942006063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1117942006064	SdpI/YhfL protein family; Region: SdpI; pfam13630
1117942006065	anthranilate synthase component I; Provisional; Region: PRK13564
1117942006066	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1117942006067	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1117942006068	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1117942006069	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1117942006070	glutamine binding [chemical binding]; other site
1117942006071	catalytic triad [active]
1117942006072	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1117942006073	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1117942006074	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1117942006075	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1117942006076	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1117942006077	active site
1117942006078	ribulose/triose binding site [chemical binding]; other site
1117942006079	phosphate binding site [ion binding]; other site
1117942006080	substrate (anthranilate) binding pocket [chemical binding]; other site
1117942006081	product (indole) binding pocket [chemical binding]; other site
1117942006082	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1117942006083	active site
1117942006084	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1117942006085	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1117942006086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1117942006087	catalytic residue [active]
1117942006088	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1117942006089	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1117942006090	substrate binding site [chemical binding]; other site
1117942006091	active site
1117942006092	catalytic residues [active]
1117942006093	heterodimer interface [polypeptide binding]; other site
1117942006094	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1117942006095	iron-sulfur cluster [ion binding]; other site
1117942006096	[2Fe-2S] cluster binding site [ion binding]; other site
1117942006097	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1117942006098	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1117942006099	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1117942006100	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1117942006101	hypothetical protein; Validated; Region: PRK00228
1117942006102	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1117942006103	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1117942006104	active site
1117942006105	NTP binding site [chemical binding]; other site
1117942006106	metal binding triad [ion binding]; metal-binding site
1117942006107	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1117942006108	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1117942006109	Zn2+ binding site [ion binding]; other site
1117942006110	Mg2+ binding site [ion binding]; other site
1117942006111	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1117942006112	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1117942006113	active site
1117942006114	Ap6A binding site [chemical binding]; other site
1117942006115	nudix motif; other site
1117942006116	metal binding site [ion binding]; metal-binding site
1117942006117	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1117942006118	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1117942006119	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1117942006120	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1117942006121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1117942006122	DNA binding residues [nucleotide binding]
1117942006123	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1117942006124	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1117942006125	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1117942006126	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1117942006127	catalytic residues [active]
1117942006128	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1117942006129	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1117942006130	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1117942006131	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1117942006132	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1117942006133	active site
1117942006134	metal binding site [ion binding]; metal-binding site
1117942006135	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1117942006136	ParB-like nuclease domain; Region: ParBc; pfam02195
1117942006137	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1117942006138	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1117942006139	P-loop; other site
1117942006140	Magnesium ion binding site [ion binding]; other site
1117942006141	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1117942006142	Magnesium ion binding site [ion binding]; other site
1117942006143	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1117942006144	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1117942006145	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
1117942006146	Haemolytic domain; Region: Haemolytic; pfam01809
1117942006147	ribonuclease P; Reviewed; Region: rnpA; PRK03459
1117942006148	Ribosomal protein L34; Region: Ribosomal_L34; cl00370