-- dump date   	20140619_052813
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
662755000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
662755000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755000003	Walker A motif; other site
662755000004	ATP binding site [chemical binding]; other site
662755000005	Walker B motif; other site
662755000006	arginine finger; other site
662755000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
662755000008	DnaA box-binding interface [nucleotide binding]; other site
662755000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
662755000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
662755000011	putative DNA binding surface [nucleotide binding]; other site
662755000012	dimer interface [polypeptide binding]; other site
662755000013	beta-clamp/clamp loader binding surface; other site
662755000014	beta-clamp/translesion DNA polymerase binding surface; other site
662755000015	recombination protein F; Reviewed; Region: recF; PRK00064
662755000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
662755000017	Walker A/P-loop; other site
662755000018	ATP binding site [chemical binding]; other site
662755000019	Q-loop/lid; other site
662755000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000021	ABC transporter signature motif; other site
662755000022	Walker B; other site
662755000023	D-loop; other site
662755000024	H-loop/switch region; other site
662755000025	Protein of unknown function (DUF721); Region: DUF721; cl02324
662755000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
662755000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755000028	ATP binding site [chemical binding]; other site
662755000029	Mg2+ binding site [ion binding]; other site
662755000030	G-X-G motif; other site
662755000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
662755000032	anchoring element; other site
662755000033	dimer interface [polypeptide binding]; other site
662755000034	ATP binding site [chemical binding]; other site
662755000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
662755000036	active site
662755000037	putative metal-binding site [ion binding]; other site
662755000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
662755000039	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
662755000040	DNA gyrase subunit A; Validated; Region: PRK05560
662755000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
662755000042	CAP-like domain; other site
662755000043	active site
662755000044	primary dimer interface [polypeptide binding]; other site
662755000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
662755000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
662755000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
662755000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
662755000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
662755000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
662755000051	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
662755000052	Domain of unknown function (DUF222); Region: DUF222; pfam02720
662755000053	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
662755000054	active site
662755000055	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
662755000056	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
662755000057	active site
662755000058	catalytic residues [active]
662755000059	DNA binding site [nucleotide binding]
662755000060	Int/Topo IB signature motif; other site
662755000061	Helix-turn-helix domain; Region: HTH_17; cl17695
662755000062	putative transposase OrfB; Reviewed; Region: PHA02517
662755000063	HTH-like domain; Region: HTH_21; pfam13276
662755000064	Integrase core domain; Region: rve; pfam00665
662755000065	Integrase core domain; Region: rve_3; pfam13683
662755000066	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
662755000067	Transposase; Region: HTH_Tnp_1; pfam01527
662755000068	MULE transposase domain; Region: MULE; pfam10551
662755000069	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755000070	active site
662755000071	CoA binding site [chemical binding]; other site
662755000072	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
662755000073	AMP binding site [chemical binding]; other site
662755000074	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
662755000075	MULE transposase domain; Region: MULE; pfam10551
662755000076	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755000077	acyl-activating enzyme (AAE) consensus motif; other site
662755000078	potential frameshift: common BLAST hit: gi|17158096|ref|NP_478092.1| TraA protein
662755000079	TrwC relaxase; Region: TrwC; pfam08751
662755000080	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
662755000081	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
662755000082	AAA domain; Region: AAA_30; pfam13604
662755000083	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
662755000084	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
662755000085	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
662755000086	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
662755000087	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
662755000088	catalytic residue [active]
662755000089	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
662755000090	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
662755000091	dimer interface [polypeptide binding]; other site
662755000092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000093	catalytic residue [active]
662755000094	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
662755000095	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
662755000096	cation binding site [ion binding]; other site
662755000097	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
662755000098	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755000099	intersubunit interface [polypeptide binding]; other site
662755000100	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755000101	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755000102	dimer interface [polypeptide binding]; other site
662755000103	putative PBP binding regions; other site
662755000104	ABC-ATPase subunit  interface; other site
662755000105	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
662755000106	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
662755000107	Walker A/P-loop; other site
662755000108	ATP binding site [chemical binding]; other site
662755000109	Q-loop/lid; other site
662755000110	ABC transporter signature motif; other site
662755000111	Walker B; other site
662755000112	D-loop; other site
662755000113	H-loop/switch region; other site
662755000114	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
662755000115	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
662755000116	NAD(P) binding site [chemical binding]; other site
662755000117	catalytic residues [active]
662755000118	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
662755000119	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755000120	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
662755000121	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
662755000122	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
662755000123	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
662755000124	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
662755000125	active site
662755000126	Rhomboid family; Region: Rhomboid; cl11446
662755000127	putative septation inhibitor protein; Reviewed; Region: PRK00159
662755000128	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
662755000129	Glutamine amidotransferase class-I; Region: GATase; pfam00117
662755000130	glutamine binding [chemical binding]; other site
662755000131	catalytic triad [active]
662755000132	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
662755000133	Catalytic domain of Protein Kinases; Region: PKc; cd00180
662755000134	active site
662755000135	ATP binding site [chemical binding]; other site
662755000136	substrate binding site [chemical binding]; other site
662755000137	activation loop (A-loop); other site
662755000138	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
662755000139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
662755000140	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755000141	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755000142	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755000143	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755000144	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
662755000145	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
662755000146	active site
662755000147	ATP binding site [chemical binding]; other site
662755000148	substrate binding site [chemical binding]; other site
662755000149	activation loop (A-loop); other site
662755000150	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
662755000151	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
662755000152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
662755000153	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
662755000154	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
662755000155	Protein phosphatase 2C; Region: PP2C; pfam00481
662755000156	active site
662755000157	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
662755000158	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
662755000159	phosphopeptide binding site; other site
662755000160	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
662755000161	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
662755000162	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
662755000163	phosphopeptide binding site; other site
662755000164	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
662755000165	POT family; Region: PTR2; cl17359
662755000166	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
662755000167	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
662755000168	inhibitor-cofactor binding pocket; inhibition site
662755000169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000170	catalytic residue [active]
662755000171	AAA domain; Region: AAA_26; pfam13500
662755000172	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
662755000173	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
662755000174	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
662755000175	potential catalytic triad [active]
662755000176	conserved cys residue [active]
662755000177	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
662755000178	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
662755000179	dimer interface [polypeptide binding]; other site
662755000180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000181	catalytic residue [active]
662755000182	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
662755000183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
662755000184	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
662755000185	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
662755000186	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
662755000187	catalytic residue [active]
662755000188	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
662755000189	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
662755000190	Sulfate transporter family; Region: Sulfate_transp; pfam00916
662755000191	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
662755000192	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
662755000193	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755000194	intersubunit interface [polypeptide binding]; other site
662755000195	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755000196	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755000197	dimer interface [polypeptide binding]; other site
662755000198	putative PBP binding regions; other site
662755000199	ABC-ATPase subunit  interface; other site
662755000200	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755000201	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755000202	ABC-ATPase subunit  interface; other site
662755000203	dimer interface [polypeptide binding]; other site
662755000204	putative PBP binding regions; other site
662755000205	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
662755000206	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
662755000207	Walker A/P-loop; other site
662755000208	ATP binding site [chemical binding]; other site
662755000209	Q-loop/lid; other site
662755000210	ABC transporter signature motif; other site
662755000211	Walker B; other site
662755000212	D-loop; other site
662755000213	H-loop/switch region; other site
662755000214	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
662755000215	DNA-binding site [nucleotide binding]; DNA binding site
662755000216	DDE domain; Region: DDE_Tnp_IS240; pfam13610
662755000217	Integrase core domain; Region: rve; pfam00665
662755000218	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
662755000219	Transposase; Region: DEDD_Tnp_IS110; pfam01548
662755000220	Transposase; Region: DEDD_Tnp_IS110; pfam01548
662755000221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
662755000222	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
662755000223	MULE transposase domain; Region: MULE; pfam10551
662755000224	HTH-like domain; Region: HTH_21; pfam13276
662755000225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
662755000226	Integrase core domain; Region: rve; pfam00665
662755000227	Integrase core domain; Region: rve_3; pfam13683
662755000228	Transposase; Region: HTH_Tnp_1; cl17663
662755000229	MULE transposase domain; Region: MULE; pfam10551
662755000230	MULE transposase domain; Region: MULE; pfam10551
662755000231	aminotransferase AlaT; Validated; Region: PRK09265
662755000232	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755000233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000234	homodimer interface [polypeptide binding]; other site
662755000235	catalytic residue [active]
662755000236	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
662755000237	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
662755000238	active site
662755000239	DNA binding site [nucleotide binding]
662755000240	Homeodomain-like domain; Region: HTH_23; pfam13384
662755000241	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755000242	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755000243	Integrase core domain; Region: rve; pfam00665
662755000244	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
662755000245	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
662755000246	4Fe-4S binding domain; Region: Fer4; cl02805
662755000247	4Fe-4S binding domain; Region: Fer4; pfam00037
662755000248	Cysteine-rich domain; Region: CCG; pfam02754
662755000249	Cysteine-rich domain; Region: CCG; pfam02754
662755000250	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
662755000251	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
662755000252	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
662755000253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755000254	dimer interface [polypeptide binding]; other site
662755000255	conserved gate region; other site
662755000256	putative PBP binding loops; other site
662755000257	ABC-ATPase subunit interface; other site
662755000258	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
662755000259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755000260	dimer interface [polypeptide binding]; other site
662755000261	conserved gate region; other site
662755000262	putative PBP binding loops; other site
662755000263	ABC-ATPase subunit interface; other site
662755000264	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
662755000265	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
662755000266	Walker A/P-loop; other site
662755000267	ATP binding site [chemical binding]; other site
662755000268	Q-loop/lid; other site
662755000269	ABC transporter signature motif; other site
662755000270	Walker B; other site
662755000271	D-loop; other site
662755000272	H-loop/switch region; other site
662755000273	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
662755000274	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
662755000275	Walker A/P-loop; other site
662755000276	ATP binding site [chemical binding]; other site
662755000277	Q-loop/lid; other site
662755000278	ABC transporter signature motif; other site
662755000279	Walker B; other site
662755000280	D-loop; other site
662755000281	H-loop/switch region; other site
662755000282	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
662755000283	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
662755000284	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
662755000285	nucleotide binding site [chemical binding]; other site
662755000286	NEF interaction site [polypeptide binding]; other site
662755000287	SBD interface [polypeptide binding]; other site
662755000288	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
662755000289	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
662755000290	dimer interface [polypeptide binding]; other site
662755000291	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
662755000292	Integrase core domain; Region: rve; pfam00665
662755000293	Integrase core domain; Region: rve_2; pfam13333
662755000294	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
662755000295	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755000296	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
662755000297	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
662755000298	hinge; other site
662755000299	active site
662755000300	GAF domain; Region: GAF; cl17456
662755000301	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755000302	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755000303	DNA binding residues [nucleotide binding]
662755000304	dimerization interface [polypeptide binding]; other site
662755000305	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
662755000306	enoyl-CoA hydratase; Provisional; Region: PRK05862
662755000307	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755000308	substrate binding site [chemical binding]; other site
662755000309	oxyanion hole (OAH) forming residues; other site
662755000310	trimer interface [polypeptide binding]; other site
662755000311	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
662755000312	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
662755000313	dimer interface [polypeptide binding]; other site
662755000314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000315	catalytic residue [active]
662755000316	serine O-acetyltransferase; Region: cysE; TIGR01172
662755000317	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
662755000318	trimer interface [polypeptide binding]; other site
662755000319	active site
662755000320	substrate binding site [chemical binding]; other site
662755000321	CoA binding site [chemical binding]; other site
662755000322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755000323	Coenzyme A binding pocket [chemical binding]; other site
662755000324	MULE transposase domain; Region: MULE; pfam10551
662755000325	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
662755000326	MULE transposase domain; Region: MULE; pfam10551
662755000327	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
662755000328	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
662755000329	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
662755000330	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
662755000331	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
662755000332	FMN binding site [chemical binding]; other site
662755000333	active site
662755000334	catalytic residues [active]
662755000335	substrate binding site [chemical binding]; other site
662755000336	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
662755000337	PhoU domain; Region: PhoU; pfam01895
662755000338	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
662755000339	AAA domain; Region: AAA_33; pfam13671
662755000340	ATP-binding site [chemical binding]; other site
662755000341	Gluconate-6-phosphate binding site [chemical binding]; other site
662755000342	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
662755000343	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
662755000344	Walker A/P-loop; other site
662755000345	ATP binding site [chemical binding]; other site
662755000346	Q-loop/lid; other site
662755000347	ABC transporter signature motif; other site
662755000348	Walker B; other site
662755000349	D-loop; other site
662755000350	H-loop/switch region; other site
662755000351	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
662755000352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755000353	dimer interface [polypeptide binding]; other site
662755000354	conserved gate region; other site
662755000355	putative PBP binding loops; other site
662755000356	ABC-ATPase subunit interface; other site
662755000357	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
662755000358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755000359	dimer interface [polypeptide binding]; other site
662755000360	conserved gate region; other site
662755000361	putative PBP binding loops; other site
662755000362	ABC-ATPase subunit interface; other site
662755000363	PBP superfamily domain; Region: PBP_like_2; cl17296
662755000364	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
662755000365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755000366	Coenzyme A binding pocket [chemical binding]; other site
662755000367	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
662755000368	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
662755000369	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
662755000370	DNA binding site [nucleotide binding]
662755000371	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
662755000372	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
662755000373	heme-binding site [chemical binding]; other site
662755000374	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
662755000375	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
662755000376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000377	catalytic residue [active]
662755000378	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
662755000379	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
662755000380	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
662755000381	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
662755000382	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
662755000383	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
662755000384	dimerization interface [polypeptide binding]; other site
662755000385	putative ATP binding site [chemical binding]; other site
662755000386	amidophosphoribosyltransferase; Provisional; Region: PRK07847
662755000387	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
662755000388	active site
662755000389	tetramer interface [polypeptide binding]; other site
662755000390	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755000391	active site
662755000392	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
662755000393	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
662755000394	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
662755000395	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
662755000396	dimerization interface [polypeptide binding]; other site
662755000397	ATP binding site [chemical binding]; other site
662755000398	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
662755000399	dimerization interface [polypeptide binding]; other site
662755000400	ATP binding site [chemical binding]; other site
662755000401	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
662755000402	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
662755000403	putative active site [active]
662755000404	catalytic triad [active]
662755000405	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
662755000406	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
662755000407	putative active site [active]
662755000408	putative Zn binding site [ion binding]; other site
662755000409	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
662755000410	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
662755000411	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
662755000412	ATP binding site [chemical binding]; other site
662755000413	active site
662755000414	substrate binding site [chemical binding]; other site
662755000415	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
662755000416	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
662755000417	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
662755000418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755000419	dimer interface [polypeptide binding]; other site
662755000420	conserved gate region; other site
662755000421	putative PBP binding loops; other site
662755000422	ABC-ATPase subunit interface; other site
662755000423	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
662755000424	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
662755000425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755000426	dimer interface [polypeptide binding]; other site
662755000427	conserved gate region; other site
662755000428	putative PBP binding loops; other site
662755000429	ABC-ATPase subunit interface; other site
662755000430	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
662755000431	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
662755000432	Walker A/P-loop; other site
662755000433	ATP binding site [chemical binding]; other site
662755000434	Q-loop/lid; other site
662755000435	ABC transporter signature motif; other site
662755000436	Walker B; other site
662755000437	D-loop; other site
662755000438	H-loop/switch region; other site
662755000439	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
662755000440	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
662755000441	Walker A/P-loop; other site
662755000442	ATP binding site [chemical binding]; other site
662755000443	Q-loop/lid; other site
662755000444	ABC transporter signature motif; other site
662755000445	Walker B; other site
662755000446	D-loop; other site
662755000447	H-loop/switch region; other site
662755000448	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
662755000449	adenylosuccinate lyase; Region: purB; TIGR00928
662755000450	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
662755000451	tetramer interface [polypeptide binding]; other site
662755000452	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
662755000453	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
662755000454	putative DNA binding site [nucleotide binding]; other site
662755000455	catalytic residue [active]
662755000456	putative H2TH interface [polypeptide binding]; other site
662755000457	putative catalytic residues [active]
662755000458	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
662755000459	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
662755000460	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
662755000461	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
662755000462	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
662755000463	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
662755000464	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
662755000465	nucleotide binding site/active site [active]
662755000466	HIT family signature motif; other site
662755000467	catalytic residue [active]
662755000468	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
662755000469	Lipase (class 2); Region: Lipase_2; pfam01674
662755000470	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
662755000471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
662755000472	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
662755000473	dimerization interface [polypeptide binding]; other site
662755000474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
662755000475	dimer interface [polypeptide binding]; other site
662755000476	phosphorylation site [posttranslational modification]
662755000477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755000478	ATP binding site [chemical binding]; other site
662755000479	Mg2+ binding site [ion binding]; other site
662755000480	G-X-G motif; other site
662755000481	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
662755000482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755000483	active site
662755000484	phosphorylation site [posttranslational modification]
662755000485	intermolecular recognition site; other site
662755000486	dimerization interface [polypeptide binding]; other site
662755000487	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
662755000488	DNA binding site [nucleotide binding]
662755000489	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
662755000490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
662755000491	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
662755000492	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755000493	Integrase core domain; Region: rve; pfam00665
662755000494	Integrase core domain; Region: rve_2; pfam13333
662755000495	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
662755000496	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
662755000497	Active Sites [active]
662755000498	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
662755000499	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
662755000500	Active Sites [active]
662755000501	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
662755000502	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
662755000503	CysD dimerization site [polypeptide binding]; other site
662755000504	G1 box; other site
662755000505	putative GEF interaction site [polypeptide binding]; other site
662755000506	GTP/Mg2+ binding site [chemical binding]; other site
662755000507	Switch I region; other site
662755000508	G2 box; other site
662755000509	G3 box; other site
662755000510	Switch II region; other site
662755000511	G4 box; other site
662755000512	G5 box; other site
662755000513	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
662755000514	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
662755000515	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
662755000516	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
662755000517	putative active site [active]
662755000518	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
662755000519	active site
662755000520	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
662755000521	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
662755000522	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
662755000523	propionate/acetate kinase; Provisional; Region: PRK12379
662755000524	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
662755000525	Catalytic domain of Protein Kinases; Region: PKc; cd00180
662755000526	active site
662755000527	ATP binding site [chemical binding]; other site
662755000528	substrate binding site [chemical binding]; other site
662755000529	activation loop (A-loop); other site
662755000530	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
662755000531	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
662755000532	substrate binding pocket [chemical binding]; other site
662755000533	membrane-bound complex binding site; other site
662755000534	hinge residues; other site
662755000535	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
662755000536	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
662755000537	Walker A/P-loop; other site
662755000538	ATP binding site [chemical binding]; other site
662755000539	Q-loop/lid; other site
662755000540	ABC transporter signature motif; other site
662755000541	Walker B; other site
662755000542	D-loop; other site
662755000543	H-loop/switch region; other site
662755000544	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
662755000545	MarR family; Region: MarR; pfam01047
662755000546	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
662755000547	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
662755000548	putative active site [active]
662755000549	catalytic site [active]
662755000550	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
662755000551	putative active site [active]
662755000552	catalytic site [active]
662755000553	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
662755000554	putative catalytic site [active]
662755000555	putative metal binding site [ion binding]; other site
662755000556	putative phosphate binding site [ion binding]; other site
662755000557	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755000558	Coenzyme A binding pocket [chemical binding]; other site
662755000559	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
662755000560	active site
662755000561	catalytic residues [active]
662755000562	metal binding site [ion binding]; metal-binding site
662755000563	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
662755000564	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
662755000565	carboxylate-amine ligase; Provisional; Region: PRK13517
662755000566	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
662755000567	hypothetical protein; Provisional; Region: PRK07907
662755000568	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
662755000569	active site
662755000570	metal binding site [ion binding]; metal-binding site
662755000571	dimer interface [polypeptide binding]; other site
662755000572	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
662755000573	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
662755000574	ring oligomerisation interface [polypeptide binding]; other site
662755000575	ATP/Mg binding site [chemical binding]; other site
662755000576	stacking interactions; other site
662755000577	hinge regions; other site
662755000578	hypothetical protein; Provisional; Region: PRK10621
662755000579	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
662755000580	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
662755000581	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
662755000582	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
662755000583	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755000584	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
662755000585	acyl-activating enzyme (AAE) consensus motif; other site
662755000586	AMP binding site [chemical binding]; other site
662755000587	active site
662755000588	CoA binding site [chemical binding]; other site
662755000589	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
662755000590	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
662755000591	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
662755000592	putative trimer interface [polypeptide binding]; other site
662755000593	putative CoA binding site [chemical binding]; other site
662755000594	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
662755000595	putative trimer interface [polypeptide binding]; other site
662755000596	putative CoA binding site [chemical binding]; other site
662755000597	Transcriptional regulators [Transcription]; Region: MarR; COG1846
662755000598	MarR family; Region: MarR; pfam01047
662755000599	MarR family; Region: MarR_2; cl17246
662755000600	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
662755000601	active site residue [active]
662755000602	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
662755000603	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
662755000604	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
662755000605	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
662755000606	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
662755000607	spermidine synthase; Provisional; Region: PRK03612
662755000608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755000609	S-adenosylmethionine binding site [chemical binding]; other site
662755000610	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
662755000611	dimer interface [polypeptide binding]; other site
662755000612	substrate binding site [chemical binding]; other site
662755000613	metal binding sites [ion binding]; metal-binding site
662755000614	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
662755000615	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
662755000616	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
662755000617	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
662755000618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755000619	active site
662755000620	FtsH Extracellular; Region: FtsH_ext; pfam06480
662755000621	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
662755000622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755000623	Walker A motif; other site
662755000624	ATP binding site [chemical binding]; other site
662755000625	Walker B motif; other site
662755000626	arginine finger; other site
662755000627	Peptidase family M41; Region: Peptidase_M41; pfam01434
662755000628	GTP cyclohydrolase I; Provisional; Region: PLN03044
662755000629	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
662755000630	homodecamer interface [polypeptide binding]; other site
662755000631	active site
662755000632	putative catalytic site residues [active]
662755000633	zinc binding site [ion binding]; other site
662755000634	GTP-CH-I/GFRP interaction surface; other site
662755000635	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
662755000636	dihydropteroate synthase; Region: DHPS; TIGR01496
662755000637	substrate binding pocket [chemical binding]; other site
662755000638	dimer interface [polypeptide binding]; other site
662755000639	inhibitor binding site; inhibition site
662755000640	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
662755000641	homooctamer interface [polypeptide binding]; other site
662755000642	active site
662755000643	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
662755000644	catalytic center binding site [active]
662755000645	ATP binding site [chemical binding]; other site
662755000646	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
662755000647	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
662755000648	Uncharacterized conserved protein [Function unknown]; Region: COG5495
662755000649	Rossmann-like domain; Region: Rossmann-like; pfam10727
662755000650	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
662755000651	Pantoate-beta-alanine ligase; Region: PanC; cd00560
662755000652	pantoate--beta-alanine ligase; Region: panC; TIGR00018
662755000653	active site
662755000654	ATP-binding site [chemical binding]; other site
662755000655	pantoate-binding site; other site
662755000656	HXXH motif; other site
662755000657	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
662755000658	active site
662755000659	catalytic residues [active]
662755000660	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
662755000661	Na binding site [ion binding]; other site
662755000662	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
662755000663	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
662755000664	dimer interface [polypeptide binding]; other site
662755000665	active site
662755000666	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
662755000667	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
662755000668	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
662755000669	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
662755000670	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
662755000671	tetramerization interface [polypeptide binding]; other site
662755000672	active site
662755000673	Transcriptional regulator; Region: Rrf2; cl17282
662755000674	Rrf2 family protein; Region: rrf2_super; TIGR00738
662755000675	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
662755000676	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
662755000677	heme-binding site [chemical binding]; other site
662755000678	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
662755000679	FAD binding pocket [chemical binding]; other site
662755000680	conserved FAD binding motif [chemical binding]; other site
662755000681	phosphate binding motif [ion binding]; other site
662755000682	beta-alpha-beta structure motif; other site
662755000683	NAD binding pocket [chemical binding]; other site
662755000684	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
662755000685	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
662755000686	dimer interface [polypeptide binding]; other site
662755000687	putative anticodon binding site; other site
662755000688	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
662755000689	motif 1; other site
662755000690	dimer interface [polypeptide binding]; other site
662755000691	active site
662755000692	motif 2; other site
662755000693	motif 3; other site
662755000694	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755000695	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755000696	active site
662755000697	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755000698	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755000699	active site
662755000700	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
662755000701	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
662755000702	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
662755000703	KRI1-like family; Region: Kri1; pfam05178
662755000704	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
662755000705	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
662755000706	dimer interface [polypeptide binding]; other site
662755000707	substrate binding site [chemical binding]; other site
662755000708	ATP binding site [chemical binding]; other site
662755000709	acyl-CoA synthetase; Provisional; Region: PRK13382
662755000710	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755000711	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755000712	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755000713	acyl-activating enzyme (AAE) consensus motif; other site
662755000714	AMP binding site [chemical binding]; other site
662755000715	active site
662755000716	CoA binding site [chemical binding]; other site
662755000717	Clp protease ATP binding subunit; Region: clpC; CHL00095
662755000718	Clp amino terminal domain; Region: Clp_N; pfam02861
662755000719	Clp amino terminal domain; Region: Clp_N; pfam02861
662755000720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755000721	Walker A motif; other site
662755000722	ATP binding site [chemical binding]; other site
662755000723	Walker B motif; other site
662755000724	arginine finger; other site
662755000725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755000726	Walker A motif; other site
662755000727	ATP binding site [chemical binding]; other site
662755000728	Walker B motif; other site
662755000729	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
662755000730	Secretory lipase; Region: LIP; pfam03583
662755000731	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
662755000732	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
662755000733	minor groove reading motif; other site
662755000734	helix-hairpin-helix signature motif; other site
662755000735	active site
662755000736	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
662755000737	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
662755000738	active site clefts [active]
662755000739	zinc binding site [ion binding]; other site
662755000740	dimer interface [polypeptide binding]; other site
662755000741	DNA repair protein RadA; Provisional; Region: PRK11823
662755000742	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
662755000743	Walker A motif; other site
662755000744	ATP binding site [chemical binding]; other site
662755000745	Walker B motif; other site
662755000746	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
662755000747	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
662755000748	substrate binding site; other site
662755000749	dimer interface; other site
662755000750	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084
662755000751	homotrimer interaction site [polypeptide binding]; other site
662755000752	zinc binding site [ion binding]; other site
662755000753	CDP-binding sites; other site
662755000754	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
662755000755	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000756	Walker A/P-loop; other site
662755000757	ATP binding site [chemical binding]; other site
662755000758	Q-loop/lid; other site
662755000759	ABC transporter signature motif; other site
662755000760	Walker B; other site
662755000761	D-loop; other site
662755000762	H-loop/switch region; other site
662755000763	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
662755000764	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
662755000765	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
662755000766	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
662755000767	active site
662755000768	HIGH motif; other site
662755000769	nucleotide binding site [chemical binding]; other site
662755000770	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
662755000771	KMSKS motif; other site
662755000772	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
662755000773	Predicted flavoprotein [General function prediction only]; Region: COG0431
662755000774	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
662755000775	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
662755000776	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
662755000777	dimer interface [polypeptide binding]; other site
662755000778	putative radical transfer pathway; other site
662755000779	diiron center [ion binding]; other site
662755000780	tyrosyl radical; other site
662755000781	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
662755000782	Htaa; Region: HtaA; pfam04213
662755000783	Htaa; Region: HtaA; pfam04213
662755000784	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
662755000785	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755000786	intersubunit interface [polypeptide binding]; other site
662755000787	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755000788	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755000789	ABC-ATPase subunit  interface; other site
662755000790	dimer interface [polypeptide binding]; other site
662755000791	putative PBP binding regions; other site
662755000792	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
662755000793	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
662755000794	Walker A/P-loop; other site
662755000795	ATP binding site [chemical binding]; other site
662755000796	Q-loop/lid; other site
662755000797	ABC transporter signature motif; other site
662755000798	Walker B; other site
662755000799	D-loop; other site
662755000800	H-loop/switch region; other site
662755000801	Htaa; Region: HtaA; pfam04213
662755000802	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
662755000803	heme binding pocket [chemical binding]; other site
662755000804	heme ligand [chemical binding]; other site
662755000805	Htaa; Region: HtaA; pfam04213
662755000806	benzoate transport; Region: 2A0115; TIGR00895
662755000807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755000808	putative substrate translocation pore; other site
662755000809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755000810	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
662755000811	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
662755000812	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
662755000813	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
662755000814	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
662755000815	substrate binding pocket [chemical binding]; other site
662755000816	catalytic triad [active]
662755000817	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
662755000818	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
662755000819	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
662755000820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000821	Walker A/P-loop; other site
662755000822	ATP binding site [chemical binding]; other site
662755000823	Q-loop/lid; other site
662755000824	ABC transporter signature motif; other site
662755000825	Walker B; other site
662755000826	D-loop; other site
662755000827	H-loop/switch region; other site
662755000828	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755000829	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
662755000830	intersubunit interface [polypeptide binding]; other site
662755000831	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
662755000832	ornithine cyclodeaminase; Validated; Region: PRK07589
662755000833	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
662755000834	Transcriptional regulators [Transcription]; Region: PurR; COG1609
662755000835	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
662755000836	DNA binding site [nucleotide binding]
662755000837	domain linker motif; other site
662755000838	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
662755000839	putative dimerization interface [polypeptide binding]; other site
662755000840	putative ligand binding site [chemical binding]; other site
662755000841	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
662755000842	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
662755000843	META domain; Region: META; cl01245
662755000844	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
662755000845	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
662755000846	active site
662755000847	homotetramer interface [polypeptide binding]; other site
662755000848	Uncharacterized conserved protein [Function unknown]; Region: COG2966
662755000849	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
662755000850	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
662755000851	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
662755000852	Integrase core domain; Region: rve; pfam00665
662755000853	Integrase core domain; Region: rve_2; pfam13333
662755000854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
662755000855	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755000856	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
662755000857	active site
662755000858	Shikimate kinase; Region: SKI; pfam01202
662755000859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
662755000860	Integrase core domain; Region: rve; pfam00665
662755000861	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
662755000862	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
662755000863	potential frameshift: common BLAST hit: gi|30387207|ref|NP_848184.1| ResA
662755000864	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
662755000865	catalytic nucleophile [active]
662755000866	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
662755000867	Resolvase, N terminal domain; Region: Resolvase; pfam00239
662755000868	catalytic residues [active]
662755000869	Alpha amylase inhibitor; Region: A_amylase_inhib; cl03178
662755000870	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755000871	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755000872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000873	Walker A/P-loop; other site
662755000874	ATP binding site [chemical binding]; other site
662755000875	Q-loop/lid; other site
662755000876	ABC transporter signature motif; other site
662755000877	Walker B; other site
662755000878	D-loop; other site
662755000879	H-loop/switch region; other site
662755000880	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000881	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755000882	Q-loop/lid; other site
662755000883	ABC transporter signature motif; other site
662755000884	Walker B; other site
662755000885	D-loop; other site
662755000886	H-loop/switch region; other site
662755000887	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
662755000888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
662755000889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
662755000890	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
662755000891	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
662755000892	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755000893	ATP binding site [chemical binding]; other site
662755000894	putative Mg++ binding site [ion binding]; other site
662755000895	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755000896	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755000897	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
662755000898	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
662755000899	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
662755000900	ferredoxin-NADP+ reductase; Region: PLN02852
662755000901	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755000902	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755000903	Coenzyme A binding pocket [chemical binding]; other site
662755000904	hypothetical protein; Validated; Region: PRK01415
662755000905	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
662755000906	active site residue [active]
662755000907	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
662755000908	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755000909	ATP-grasp domain; Region: ATP-grasp; pfam02222
662755000910	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
662755000911	iron-sulfur cluster [ion binding]; other site
662755000912	[2Fe-2S] cluster binding site [ion binding]; other site
662755000913	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000914	ABC transporter signature motif; other site
662755000915	Walker B; other site
662755000916	D-loop; other site
662755000917	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
662755000918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755000919	Walker A/P-loop; other site
662755000920	ATP binding site [chemical binding]; other site
662755000921	Q-loop/lid; other site
662755000922	ABC transporter signature motif; other site
662755000923	Walker B; other site
662755000924	D-loop; other site
662755000925	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
662755000926	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
662755000927	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
662755000928	THF binding site; other site
662755000929	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
662755000930	substrate binding site [chemical binding]; other site
662755000931	THF binding site; other site
662755000932	zinc-binding site [ion binding]; other site
662755000933	YibE/F-like protein; Region: YibE_F; pfam07907
662755000934	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
662755000935	active site
662755000936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
662755000937	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
662755000938	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
662755000939	GDP-binding site [chemical binding]; other site
662755000940	ACT binding site; other site
662755000941	IMP binding site; other site
662755000942	Predicted membrane protein [Function unknown]; Region: COG4129
662755000943	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
662755000944	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
662755000945	putative catalytic site [active]
662755000946	putative metal binding site [ion binding]; other site
662755000947	putative phosphate binding site [ion binding]; other site
662755000948	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
662755000949	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
662755000950	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
662755000951	active site
662755000952	intersubunit interface [polypeptide binding]; other site
662755000953	zinc binding site [ion binding]; other site
662755000954	Na+ binding site [ion binding]; other site
662755000955	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
662755000956	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
662755000957	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
662755000958	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
662755000959	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
662755000960	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755000961	active site
662755000962	Thioredoxin; Region: Thioredoxin_4; cl17273
662755000963	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
662755000964	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
662755000965	lipoyl attachment site [posttranslational modification]; other site
662755000966	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
662755000967	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
662755000968	glycine dehydrogenase; Provisional; Region: PRK05367
662755000969	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
662755000970	tetramer interface [polypeptide binding]; other site
662755000971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755000972	catalytic residue [active]
662755000973	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
662755000974	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
662755000975	catalytic residue [active]
662755000976	short chain dehydrogenase; Provisional; Region: PRK06179
662755000977	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
662755000978	NADP binding site [chemical binding]; other site
662755000979	active site
662755000980	steroid binding site; other site
662755000981	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
662755000982	HPr interaction site; other site
662755000983	glycerol kinase (GK) interaction site [polypeptide binding]; other site
662755000984	active site
662755000985	phosphorylation site [posttranslational modification]
662755000986	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
662755000987	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
662755000988	active site residue [active]
662755000989	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
662755000990	active site residue [active]
662755000991	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
662755000992	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
662755000993	NAD(P) binding site [chemical binding]; other site
662755000994	catalytic residues [active]
662755000995	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
662755000996	Clp amino terminal domain; Region: Clp_N; pfam02861
662755000997	Clp amino terminal domain; Region: Clp_N; pfam02861
662755000998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755000999	Walker A motif; other site
662755001000	ATP binding site [chemical binding]; other site
662755001001	Walker B motif; other site
662755001002	arginine finger; other site
662755001003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755001004	Walker A motif; other site
662755001005	ATP binding site [chemical binding]; other site
662755001006	Walker B motif; other site
662755001007	arginine finger; other site
662755001008	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
662755001009	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755001010	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755001011	active site
662755001012	Predicted amidohydrolase [General function prediction only]; Region: COG0388
662755001013	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
662755001014	putative active site [active]
662755001015	catalytic triad [active]
662755001016	putative dimer interface [polypeptide binding]; other site
662755001017	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
662755001018	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
662755001019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001020	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
662755001021	DNA binding residues [nucleotide binding]
662755001022	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
662755001023	putative dimer interface [polypeptide binding]; other site
662755001024	chaperone protein DnaJ; Provisional; Region: PRK14279
662755001025	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
662755001026	HSP70 interaction site [polypeptide binding]; other site
662755001027	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
662755001028	Zn binding sites [ion binding]; other site
662755001029	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
662755001030	dimer interface [polypeptide binding]; other site
662755001031	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
662755001032	active site
662755001033	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755001034	Integrase core domain; Region: rve; pfam00665
662755001035	Integrase core domain; Region: rve_2; pfam13333
662755001036	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
662755001037	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
662755001038	Walker A/P-loop; other site
662755001039	ATP binding site [chemical binding]; other site
662755001040	Q-loop/lid; other site
662755001041	ABC transporter signature motif; other site
662755001042	Walker B; other site
662755001043	D-loop; other site
662755001044	H-loop/switch region; other site
662755001045	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
662755001046	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
662755001047	FtsX-like permease family; Region: FtsX; pfam02687
662755001048	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
662755001049	FtsX-like permease family; Region: FtsX; pfam02687
662755001050	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
662755001051	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
662755001052	DNA-binding site [nucleotide binding]; DNA binding site
662755001053	FCD domain; Region: FCD; pfam07729
662755001054	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
662755001055	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
662755001056	putative Zn2+ binding site [ion binding]; other site
662755001057	putative DNA binding site [nucleotide binding]; other site
662755001058	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
662755001059	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
662755001060	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
662755001061	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
662755001062	putative Mg++ binding site [ion binding]; other site
662755001063	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755001064	nucleotide binding region [chemical binding]; other site
662755001065	ATP-binding site [chemical binding]; other site
662755001066	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
662755001067	MULE transposase domain; Region: MULE; pfam10551
662755001068	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
662755001069	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
662755001070	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
662755001071	DNA-binding site [nucleotide binding]; DNA binding site
662755001072	RNA-binding motif; other site
662755001073	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
662755001074	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
662755001075	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
662755001076	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
662755001077	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
662755001078	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
662755001079	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
662755001080	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
662755001081	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
662755001082	catalytic residue [active]
662755001083	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
662755001084	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
662755001085	dimer interface [polypeptide binding]; other site
662755001086	active site
662755001087	citrylCoA binding site [chemical binding]; other site
662755001088	NADH binding [chemical binding]; other site
662755001089	cationic pore residues; other site
662755001090	oxalacetate/citrate binding site [chemical binding]; other site
662755001091	coenzyme A binding site [chemical binding]; other site
662755001092	catalytic triad [active]
662755001093	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
662755001094	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
662755001095	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
662755001096	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
662755001097	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001098	Walker A/P-loop; other site
662755001099	ATP binding site [chemical binding]; other site
662755001100	Q-loop/lid; other site
662755001101	ABC transporter signature motif; other site
662755001102	Walker B; other site
662755001103	D-loop; other site
662755001104	H-loop/switch region; other site
662755001105	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
662755001106	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755001107	non-specific DNA binding site [nucleotide binding]; other site
662755001108	salt bridge; other site
662755001109	sequence-specific DNA binding site [nucleotide binding]; other site
662755001110	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
662755001111	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
662755001112	active site
662755001113	catalytic tetrad [active]
662755001114	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
662755001115	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755001116	substrate binding site [chemical binding]; other site
662755001117	oxyanion hole (OAH) forming residues; other site
662755001118	trimer interface [polypeptide binding]; other site
662755001119	Transposase; Region: DEDD_Tnp_IS110; pfam01548
662755001120	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755001121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001122	Walker A/P-loop; other site
662755001123	ATP binding site [chemical binding]; other site
662755001124	Q-loop/lid; other site
662755001125	ABC transporter signature motif; other site
662755001126	Walker B; other site
662755001127	D-loop; other site
662755001128	H-loop/switch region; other site
662755001129	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
662755001130	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755001131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001132	Walker A/P-loop; other site
662755001133	ATP binding site [chemical binding]; other site
662755001134	Q-loop/lid; other site
662755001135	ABC transporter signature motif; other site
662755001136	Walker B; other site
662755001137	D-loop; other site
662755001138	H-loop/switch region; other site
662755001139	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755001140	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
662755001141	Walker A/P-loop; other site
662755001142	ATP binding site [chemical binding]; other site
662755001143	Q-loop/lid; other site
662755001144	ABC transporter signature motif; other site
662755001145	Walker B; other site
662755001146	D-loop; other site
662755001147	H-loop/switch region; other site
662755001148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001149	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
662755001150	Walker A/P-loop; other site
662755001151	ATP binding site [chemical binding]; other site
662755001152	Q-loop/lid; other site
662755001153	ABC transporter signature motif; other site
662755001154	Walker B; other site
662755001155	D-loop; other site
662755001156	H-loop/switch region; other site
662755001157	Cobalt transport protein; Region: CbiQ; cl00463
662755001158	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
662755001159	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
662755001160	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
662755001161	Na binding site [ion binding]; other site
662755001162	Protein of unknown function, DUF485; Region: DUF485; pfam04341
662755001163	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
662755001164	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
662755001165	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
662755001166	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
662755001167	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
662755001168	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
662755001169	folate binding site [chemical binding]; other site
662755001170	NADP+ binding site [chemical binding]; other site
662755001171	thymidylate synthase; Reviewed; Region: thyA; PRK01827
662755001172	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
662755001173	dimerization interface [polypeptide binding]; other site
662755001174	active site
662755001175	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
662755001176	Lipase (class 2); Region: Lipase_2; pfam01674
662755001177	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
662755001178	active site
662755001179	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755001180	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
662755001181	ATP binding site [chemical binding]; other site
662755001182	putative Mg++ binding site [ion binding]; other site
662755001183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755001184	nucleotide binding region [chemical binding]; other site
662755001185	ATP-binding site [chemical binding]; other site
662755001186	DEAD/H associated; Region: DEAD_assoc; pfam08494
662755001187	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
662755001188	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
662755001189	putative DNA binding site [nucleotide binding]; other site
662755001190	catalytic residue [active]
662755001191	putative H2TH interface [polypeptide binding]; other site
662755001192	putative catalytic residues [active]
662755001193	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
662755001194	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
662755001195	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
662755001196	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
662755001197	active site
662755001198	dimer interface [polypeptide binding]; other site
662755001199	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
662755001200	dimer interface [polypeptide binding]; other site
662755001201	active site
662755001202	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
662755001203	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
662755001204	tetramerization interface [polypeptide binding]; other site
662755001205	NAD(P) binding site [chemical binding]; other site
662755001206	catalytic residues [active]
662755001207	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
662755001208	Predicted flavoprotein [General function prediction only]; Region: COG0431
662755001209	sec-independent translocase; Provisional; Region: PRK00708
662755001210	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
662755001211	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
662755001212	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
662755001213	catalytic triad [active]
662755001214	catalytic triad [active]
662755001215	oxyanion hole [active]
662755001216	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
662755001217	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
662755001218	active site
662755001219	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
662755001220	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
662755001221	active site
662755001222	peptide chain release factor 2; Validated; Region: prfB; PRK00578
662755001223	This domain is found in peptide chain release factors; Region: PCRF; smart00937
662755001224	RF-1 domain; Region: RF-1; pfam00472
662755001225	Proline dehydrogenase; Region: Pro_dh; cl03282
662755001226	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
662755001227	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
662755001228	Glutamate binding site [chemical binding]; other site
662755001229	NAD binding site [chemical binding]; other site
662755001230	catalytic residues [active]
662755001231	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
662755001232	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
662755001233	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
662755001234	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001235	Walker A/P-loop; other site
662755001236	ATP binding site [chemical binding]; other site
662755001237	Q-loop/lid; other site
662755001238	ABC transporter signature motif; other site
662755001239	Walker B; other site
662755001240	D-loop; other site
662755001241	H-loop/switch region; other site
662755001242	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
662755001243	FtsX-like permease family; Region: FtsX; pfam02687
662755001244	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
662755001245	SmpB-tmRNA interface; other site
662755001246	Winged helix-turn helix; Region: HTH_29; pfam13551
662755001247	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755001248	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
662755001249	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
662755001250	Walker A/P-loop; other site
662755001251	ATP binding site [chemical binding]; other site
662755001252	Q-loop/lid; other site
662755001253	ABC transporter signature motif; other site
662755001254	Walker B; other site
662755001255	D-loop; other site
662755001256	H-loop/switch region; other site
662755001257	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
662755001258	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755001259	ABC-ATPase subunit  interface; other site
662755001260	dimer interface [polypeptide binding]; other site
662755001261	putative PBP binding regions; other site
662755001262	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755001263	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755001264	ABC-ATPase subunit  interface; other site
662755001265	dimer interface [polypeptide binding]; other site
662755001266	putative PBP binding regions; other site
662755001267	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755001268	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
662755001269	intersubunit interface [polypeptide binding]; other site
662755001270	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
662755001271	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
662755001272	FAD binding pocket [chemical binding]; other site
662755001273	FAD binding motif [chemical binding]; other site
662755001274	phosphate binding motif [ion binding]; other site
662755001275	NAD binding pocket [chemical binding]; other site
662755001276	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
662755001277	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
662755001278	active site
662755001279	substrate binding site [chemical binding]; other site
662755001280	metal binding site [ion binding]; metal-binding site
662755001281	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
662755001282	intersubunit interface [polypeptide binding]; other site
662755001283	active site
662755001284	catalytic residue [active]
662755001285	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
662755001286	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755001287	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
662755001288	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
662755001289	phosphoglucomutase; Validated; Region: PRK07564
662755001290	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
662755001291	active site
662755001292	substrate binding site [chemical binding]; other site
662755001293	metal binding site [ion binding]; metal-binding site
662755001294	Thioredoxin; Region: Thioredoxin_4; cl17273
662755001295	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
662755001296	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
662755001297	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755001298	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755001299	DNA binding residues [nucleotide binding]
662755001300	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
662755001301	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
662755001302	nucleotide binding site [chemical binding]; other site
662755001303	putative NEF/HSP70 interaction site [polypeptide binding]; other site
662755001304	SBD interface [polypeptide binding]; other site
662755001305	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
662755001306	putative active site [active]
662755001307	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
662755001308	Dynamin family; Region: Dynamin_N; pfam00350
662755001309	G1 box; other site
662755001310	GTP/Mg2+ binding site [chemical binding]; other site
662755001311	G2 box; other site
662755001312	Switch I region; other site
662755001313	G3 box; other site
662755001314	Switch II region; other site
662755001315	G4 box; other site
662755001316	G5 box; other site
662755001317	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
662755001318	Dynamin family; Region: Dynamin_N; pfam00350
662755001319	G1 box; other site
662755001320	GTP/Mg2+ binding site [chemical binding]; other site
662755001321	G2 box; other site
662755001322	Switch I region; other site
662755001323	G3 box; other site
662755001324	Switch II region; other site
662755001325	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
662755001326	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
662755001327	active site
662755001328	catalytic site [active]
662755001329	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
662755001330	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
662755001331	active site
662755001332	catalytic site [active]
662755001333	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
662755001334	putative active site [active]
662755001335	redox center [active]
662755001336	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
662755001337	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
662755001338	homodimer interface [polypeptide binding]; other site
662755001339	NAD binding pocket [chemical binding]; other site
662755001340	ATP binding pocket [chemical binding]; other site
662755001341	Mg binding site [ion binding]; other site
662755001342	active-site loop [active]
662755001343	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
662755001344	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
662755001345	catalytic residues [active]
662755001346	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
662755001347	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
662755001348	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
662755001349	Class I ribonucleotide reductase; Region: RNR_I; cd01679
662755001350	active site
662755001351	dimer interface [polypeptide binding]; other site
662755001352	catalytic residues [active]
662755001353	effector binding site; other site
662755001354	R2 peptide binding site; other site
662755001355	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
662755001356	Ferritin-like domain; Region: Ferritin; pfam00210
662755001357	ferroxidase diiron center [ion binding]; other site
662755001358	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
662755001359	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
662755001360	dimer interface [polypeptide binding]; other site
662755001361	putative radical transfer pathway; other site
662755001362	diiron center [ion binding]; other site
662755001363	tyrosyl radical; other site
662755001364	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
662755001365	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
662755001366	D-pathway; other site
662755001367	Putative ubiquinol binding site [chemical binding]; other site
662755001368	Low-spin heme (heme b) binding site [chemical binding]; other site
662755001369	Putative water exit pathway; other site
662755001370	Binuclear center (heme o3/CuB) [ion binding]; other site
662755001371	K-pathway; other site
662755001372	Putative proton exit pathway; other site
662755001373	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
662755001374	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
662755001375	phosphoserine phosphatase SerB; Region: serB; TIGR00338
662755001376	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
662755001377	motif II; other site
662755001378	4-coumarate--CoA ligase; Region: PLN02246
662755001379	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
662755001380	acyl-activating enzyme (AAE) consensus motif; other site
662755001381	active site
662755001382	putative CoA binding site [chemical binding]; other site
662755001383	AMP binding site [chemical binding]; other site
662755001384	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
662755001385	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755001386	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755001387	DNA binding residues [nucleotide binding]
662755001388	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
662755001389	nucleotide binding site [chemical binding]; other site
662755001390	putative NEF/HSP70 interaction site [polypeptide binding]; other site
662755001391	SBD interface [polypeptide binding]; other site
662755001392	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
662755001393	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
662755001394	G1 box; other site
662755001395	G1 box; other site
662755001396	GTP/Mg2+ binding site [chemical binding]; other site
662755001397	GTP/Mg2+ binding site [chemical binding]; other site
662755001398	G2 box; other site
662755001399	Switch I region; other site
662755001400	G3 box; other site
662755001401	Switch II region; other site
662755001402	G4 box; other site
662755001403	G5 box; other site
662755001404	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
662755001405	Dynamin family; Region: Dynamin_N; pfam00350
662755001406	G1 box; other site
662755001407	GTP/Mg2+ binding site [chemical binding]; other site
662755001408	G2 box; other site
662755001409	Switch I region; other site
662755001410	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
662755001411	G3 box; other site
662755001412	Switch II region; other site
662755001413	GTP/Mg2+ binding site [chemical binding]; other site
662755001414	G4 box; other site
662755001415	G5 box; other site
662755001416	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
662755001417	DEAD/DEAH box helicase; Region: DEAD; pfam00270
662755001418	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
662755001419	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
662755001420	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
662755001421	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
662755001422	active site
662755001423	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
662755001424	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
662755001425	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
662755001426	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
662755001427	cleavage site
662755001428	Rhomboid family; Region: Rhomboid; cl11446
662755001429	glutamate racemase; Provisional; Region: PRK00865
662755001430	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
662755001431	ribonuclease PH; Reviewed; Region: rph; PRK00173
662755001432	Ribonuclease PH; Region: RNase_PH_bact; cd11362
662755001433	hexamer interface [polypeptide binding]; other site
662755001434	active site
662755001435	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
662755001436	dimerization interface [polypeptide binding]; other site
662755001437	active site
662755001438	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
662755001439	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
662755001440	metal binding site [ion binding]; metal-binding site
662755001441	putative dimer interface [polypeptide binding]; other site
662755001442	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
662755001443	Glucitol operon activator protein (GutM); Region: GutM; cl01890
662755001444	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
662755001445	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
662755001446	catalytic triad [active]
662755001447	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
662755001448	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
662755001449	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
662755001450	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
662755001451	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
662755001452	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
662755001453	Transposase; Region: DEDD_Tnp_IS110; pfam01548
662755001454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
662755001455	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
662755001456	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755001457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755001458	active site
662755001459	phosphorylation site [posttranslational modification]
662755001460	intermolecular recognition site; other site
662755001461	dimerization interface [polypeptide binding]; other site
662755001462	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755001463	DNA binding residues [nucleotide binding]
662755001464	dimerization interface [polypeptide binding]; other site
662755001465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
662755001466	Integrase core domain; Region: rve; pfam00665
662755001467	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755001468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755001469	active site
662755001470	phosphorylation site [posttranslational modification]
662755001471	intermolecular recognition site; other site
662755001472	dimerization interface [polypeptide binding]; other site
662755001473	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755001474	DNA binding residues [nucleotide binding]
662755001475	dimerization interface [polypeptide binding]; other site
662755001476	Histidine kinase; Region: HisKA_3; pfam07730
662755001477	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
662755001478	ATP binding site [chemical binding]; other site
662755001479	Mg2+ binding site [ion binding]; other site
662755001480	G-X-G motif; other site
662755001481	Transposase, Mutator family; Region: Transposase_mut; pfam00872
662755001482	IucA / IucC family; Region: IucA_IucC; pfam04183
662755001483	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
662755001484	IucA / IucC family; Region: IucA_IucC; pfam04183
662755001485	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
662755001486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755001487	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
662755001488	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
662755001489	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
662755001490	active site 2 [active]
662755001491	active site 1 [active]
662755001492	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755001493	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
662755001494	intersubunit interface [polypeptide binding]; other site
662755001495	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
662755001496	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
662755001497	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
662755001498	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
662755001499	DDE domain; Region: DDE_Tnp_IS240; pfam13610
662755001500	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
662755001501	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
662755001502	LGFP repeat; Region: LGFP; pfam08310
662755001503	LGFP repeat; Region: LGFP; pfam08310
662755001504	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
662755001505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755001506	Walker A/P-loop; other site
662755001507	ATP binding site [chemical binding]; other site
662755001508	Q-loop/lid; other site
662755001509	ABC transporter signature motif; other site
662755001510	Walker B; other site
662755001511	D-loop; other site
662755001512	H-loop/switch region; other site
662755001513	ABC transporter; Region: ABC_tran_2; pfam12848
662755001514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755001515	cystathionine gamma-synthase; Provisional; Region: PRK07811
662755001516	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
662755001517	homodimer interface [polypeptide binding]; other site
662755001518	substrate-cofactor binding pocket; other site
662755001519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755001520	catalytic residue [active]
662755001521	EXLDI protein; Region: EXLDI; TIGR04342
662755001522	EXLDI protein; Region: EXLDI; TIGR04342
662755001523	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
662755001524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755001525	NAD(P) binding site [chemical binding]; other site
662755001526	active site
662755001527	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
662755001528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755001529	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
662755001530	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
662755001531	putative active site [active]
662755001532	putative metal binding site [ion binding]; other site
662755001533	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
662755001534	DEAD/DEAH box helicase; Region: DEAD; pfam00270
662755001535	Z1 domain; Region: Z1; pfam10593
662755001536	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
662755001537	putative active site [active]
662755001538	catalytic site [active]
662755001539	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
662755001540	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
662755001541	cofactor binding site; other site
662755001542	DNA binding site [nucleotide binding]
662755001543	substrate interaction site [chemical binding]; other site
662755001544	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
662755001545	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
662755001546	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
662755001547	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
662755001548	Nitronate monooxygenase; Region: NMO; pfam03060
662755001549	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
662755001550	FMN binding site [chemical binding]; other site
662755001551	substrate binding site [chemical binding]; other site
662755001552	putative catalytic residue [active]
662755001553	Predicted membrane protein [Function unknown]; Region: COG2261
662755001554	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
662755001555	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755001556	ATP binding site [chemical binding]; other site
662755001557	putative Mg++ binding site [ion binding]; other site
662755001558	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755001559	nucleotide binding region [chemical binding]; other site
662755001560	ATP-binding site [chemical binding]; other site
662755001561	Helicase associated domain (HA2); Region: HA2; pfam04408
662755001562	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
662755001563	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
662755001564	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
662755001565	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
662755001566	active site
662755001567	FMN binding site [chemical binding]; other site
662755001568	2,4-decadienoyl-CoA binding site; other site
662755001569	catalytic residue [active]
662755001570	4Fe-4S cluster binding site [ion binding]; other site
662755001571	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
662755001572	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
662755001573	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
662755001574	active site
662755001575	dimer interface [polypeptide binding]; other site
662755001576	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
662755001577	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
662755001578	active site
662755001579	FMN binding site [chemical binding]; other site
662755001580	substrate binding site [chemical binding]; other site
662755001581	3Fe-4S cluster binding site [ion binding]; other site
662755001582	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
662755001583	domain interface; other site
662755001584	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
662755001585	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
662755001586	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
662755001587	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
662755001588	RNA binding surface [nucleotide binding]; other site
662755001589	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
662755001590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
662755001591	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
662755001592	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
662755001593	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
662755001594	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
662755001595	active site
662755001596	Zn binding site [ion binding]; other site
662755001597	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
662755001598	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
662755001599	active site
662755001600	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
662755001601	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
662755001602	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
662755001603	LabA_like proteins; Region: LabA_like; cd06167
662755001604	putative metal binding site [ion binding]; other site
662755001605	Uncharacterized conserved protein [Function unknown]; Region: COG1432
662755001606	Predicted transcriptional regulators [Transcription]; Region: COG1725
662755001607	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
662755001608	DNA-binding site [nucleotide binding]; DNA binding site
662755001609	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
662755001610	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
662755001611	Walker A/P-loop; other site
662755001612	ATP binding site [chemical binding]; other site
662755001613	Q-loop/lid; other site
662755001614	ABC transporter signature motif; other site
662755001615	Walker B; other site
662755001616	D-loop; other site
662755001617	H-loop/switch region; other site
662755001618	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
662755001619	active site
662755001620	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
662755001621	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
662755001622	Ligand Binding Site [chemical binding]; other site
662755001623	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
662755001624	Ligand Binding Site [chemical binding]; other site
662755001625	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
662755001626	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755001627	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
662755001628	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
662755001629	active site
662755001630	catalytic site [active]
662755001631	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
662755001632	Lsr2; Region: Lsr2; pfam11774
662755001633	PhoD-like phosphatase; Region: PhoD; pfam09423
662755001634	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
662755001635	putative active site [active]
662755001636	putative metal binding site [ion binding]; other site
662755001637	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
662755001638	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
662755001639	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
662755001640	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
662755001641	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
662755001642	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
662755001643	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
662755001644	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
662755001645	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
662755001646	NAD binding site [chemical binding]; other site
662755001647	dimer interface [polypeptide binding]; other site
662755001648	tetramer (dimer of dimers) interface [polypeptide binding]; other site
662755001649	substrate binding site [chemical binding]; other site
662755001650	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
662755001651	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
662755001652	active site
662755001653	nucleophile elbow; other site
662755001654	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
662755001655	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
662755001656	active site
662755001657	catalytic site [active]
662755001658	Transcriptional regulator [Transcription]; Region: LytR; COG1316
662755001659	CAAX protease self-immunity; Region: Abi; pfam02517
662755001660	Amidase; Region: Amidase; cl11426
662755001661	Amidase; Region: Amidase; cl11426
662755001662	prephenate dehydratase; Provisional; Region: PRK11898
662755001663	Prephenate dehydratase; Region: PDT; pfam00800
662755001664	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
662755001665	putative L-Phe binding site [chemical binding]; other site
662755001666	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755001667	catalytic core [active]
662755001668	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755001669	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
662755001670	Septum formation; Region: Septum_form; pfam13845
662755001671	Septum formation; Region: Septum_form; pfam13845
662755001672	seryl-tRNA synthetase; Provisional; Region: PRK05431
662755001673	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
662755001674	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
662755001675	dimer interface [polypeptide binding]; other site
662755001676	active site
662755001677	motif 1; other site
662755001678	motif 2; other site
662755001679	motif 3; other site
662755001680	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
662755001681	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
662755001682	putative acyl-acceptor binding pocket; other site
662755001683	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
662755001684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
662755001685	active site
662755001686	motif I; other site
662755001687	motif II; other site
662755001688	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
662755001689	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
662755001690	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
662755001691	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
662755001692	UDP-galactopyranose mutase; Region: GLF; pfam03275
662755001693	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
662755001694	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001695	active site
662755001696	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001697	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
662755001698	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
662755001699	active site
662755001700	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
662755001701	UbiA prenyltransferase family; Region: UbiA; pfam01040
662755001702	Putative esterase; Region: Esterase; pfam00756
662755001703	Putative esterase; Region: Esterase; pfam00756
662755001704	S-formylglutathione hydrolase; Region: PLN02442
662755001705	LGFP repeat; Region: LGFP; pfam08310
662755001706	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
662755001707	LGFP repeat; Region: LGFP; pfam08310
662755001708	LGFP repeat; Region: LGFP; pfam08310
662755001709	Cutinase; Region: Cutinase; pfam01083
662755001710	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
662755001711	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
662755001712	acyl-activating enzyme (AAE) consensus motif; other site
662755001713	active site
662755001714	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
662755001715	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
662755001716	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
662755001717	active site
662755001718	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
662755001719	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
662755001720	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
662755001721	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
662755001722	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
662755001723	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
662755001724	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
662755001725	acyl-CoA synthetase; Validated; Region: PRK07788
662755001726	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755001727	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755001728	acyl-activating enzyme (AAE) consensus motif; other site
662755001729	acyl-activating enzyme (AAE) consensus motif; other site
662755001730	AMP binding site [chemical binding]; other site
662755001731	active site
662755001732	CoA binding site [chemical binding]; other site
662755001733	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
662755001734	active site
662755001735	catalytic triad [active]
662755001736	oxyanion hole [active]
662755001737	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
662755001738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755001739	putative substrate translocation pore; other site
662755001740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
662755001741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
662755001742	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
662755001743	putative dimerization interface [polypeptide binding]; other site
662755001744	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
662755001745	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
662755001746	Predicted integral membrane protein [Function unknown]; Region: COG0392
662755001747	MMPL family; Region: MMPL; pfam03176
662755001748	MMPL family; Region: MMPL; pfam03176
662755001749	LabA_like proteins; Region: LabA_like; cd06167
662755001750	putative metal binding site [ion binding]; other site
662755001751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755001752	S-adenosylmethionine binding site [chemical binding]; other site
662755001753	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
662755001754	active site
662755001755	substrate-binding site [chemical binding]; other site
662755001756	metal-binding site [ion binding]
662755001757	GTP binding site [chemical binding]; other site
662755001758	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
662755001759	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
662755001760	catalytic residue [active]
662755001761	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
662755001762	catalytic residues [active]
662755001763	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755001764	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
662755001765	peroxiredoxin; Region: AhpC; TIGR03137
662755001766	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
662755001767	dimer interface [polypeptide binding]; other site
662755001768	decamer (pentamer of dimers) interface [polypeptide binding]; other site
662755001769	catalytic triad [active]
662755001770	peroxidatic and resolving cysteines [active]
662755001771	amino acid transporter; Region: 2A0306; TIGR00909
662755001772	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
662755001773	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
662755001774	CPxP  motif; other site
662755001775	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
662755001776	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
662755001777	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755001778	substrate binding site [chemical binding]; other site
662755001779	oxyanion hole (OAH) forming residues; other site
662755001780	trimer interface [polypeptide binding]; other site
662755001781	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
662755001782	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
662755001783	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
662755001784	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
662755001785	dimer interface [polypeptide binding]; other site
662755001786	active site
662755001787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755001788	S-adenosylmethionine binding site [chemical binding]; other site
662755001789	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
662755001790	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
662755001791	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
662755001792	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
662755001793	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
662755001794	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
662755001795	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
662755001796	Ligand Binding Site [chemical binding]; other site
662755001797	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
662755001798	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
662755001799	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
662755001800	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
662755001801	VanW like protein; Region: VanW; pfam04294
662755001802	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
662755001803	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
662755001804	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755001805	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755001806	Integrase core domain; Region: rve; pfam00665
662755001807	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
662755001808	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
662755001809	Walker A/P-loop; other site
662755001810	ATP binding site [chemical binding]; other site
662755001811	Q-loop/lid; other site
662755001812	ABC transporter signature motif; other site
662755001813	Walker B; other site
662755001814	D-loop; other site
662755001815	H-loop/switch region; other site
662755001816	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
662755001817	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
662755001818	active site
662755001819	homodimer interface [polypeptide binding]; other site
662755001820	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
662755001821	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
662755001822	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
662755001823	active site
662755001824	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
662755001825	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
662755001826	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
662755001827	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
662755001828	Walker A/P-loop; other site
662755001829	ATP binding site [chemical binding]; other site
662755001830	Q-loop/lid; other site
662755001831	ABC transporter signature motif; other site
662755001832	Walker B; other site
662755001833	D-loop; other site
662755001834	H-loop/switch region; other site
662755001835	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
662755001836	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
662755001837	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
662755001838	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001839	active site
662755001840	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
662755001841	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
662755001842	active site
662755001843	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001844	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001845	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
662755001846	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
662755001847	active site
662755001848	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001849	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755001850	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
662755001851	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
662755001852	active site
662755001853	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
662755001854	trimer interface [polypeptide binding]; other site
662755001855	active site
662755001856	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
662755001857	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
662755001858	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
662755001859	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
662755001860	Fic family protein [Function unknown]; Region: COG3177
662755001861	Fic/DOC family; Region: Fic; cl00960
662755001862	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
662755001863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755001864	NAD(P) binding site [chemical binding]; other site
662755001865	active site
662755001866	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
662755001867	MULE transposase domain; Region: MULE; pfam10551
662755001868	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755001869	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755001870	Integrase core domain; Region: rve; pfam00665
662755001871	Bacterial Ig-like domain; Region: Big_5; pfam13205
662755001872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
662755001873	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
662755001874	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
662755001875	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
662755001876	substrate binding pocket [chemical binding]; other site
662755001877	substrate-Mg2+ binding site; other site
662755001878	aspartate-rich region 1; other site
662755001879	aspartate-rich region 2; other site
662755001880	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
662755001881	metal-binding site [ion binding]
662755001882	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
662755001883	Putative Ig domain; Region: He_PIG; pfam05345
662755001884	Rib/alpha-like repeat; Region: Rib; cl07159
662755001885	Rib/alpha-like repeat; Region: Rib; cl07159
662755001886	Rib/alpha-like repeat; Region: Rib; cl07159
662755001887	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
662755001888	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
662755001889	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
662755001890	catalytic site [active]
662755001891	putative active site [active]
662755001892	putative substrate binding site [chemical binding]; other site
662755001893	dimer interface [polypeptide binding]; other site
662755001894	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
662755001895	classical (c) SDRs; Region: SDR_c; cd05233
662755001896	NAD(P) binding site [chemical binding]; other site
662755001897	active site
662755001898	Copper resistance protein D; Region: CopD; pfam05425
662755001899	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
662755001900	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
662755001901	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755001902	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755001903	ABC transporter; Region: ABC_tran_2; pfam12848
662755001904	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755001905	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755001906	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755001907	Integrase core domain; Region: rve; pfam00665
662755001908	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
662755001909	active site
662755001910	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
662755001911	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
662755001912	apolar tunnel; other site
662755001913	heme binding site [chemical binding]; other site
662755001914	dimerization interface [polypeptide binding]; other site
662755001915	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
662755001916	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
662755001917	Zn binding site [ion binding]; other site
662755001918	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
662755001919	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
662755001920	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
662755001921	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
662755001922	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
662755001923	MULE transposase domain; Region: MULE; pfam10551
662755001924	trigger factor; Provisional; Region: tig; PRK01490
662755001925	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
662755001926	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
662755001927	Clp protease; Region: CLP_protease; pfam00574
662755001928	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
662755001929	oligomer interface [polypeptide binding]; other site
662755001930	active site residues [active]
662755001931	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
662755001932	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
662755001933	oligomer interface [polypeptide binding]; other site
662755001934	active site residues [active]
662755001935	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
662755001936	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
662755001937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755001938	Walker A motif; other site
662755001939	ATP binding site [chemical binding]; other site
662755001940	Walker B motif; other site
662755001941	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
662755001942	malate dehydrogenase; Provisional; Region: PRK05442
662755001943	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
662755001944	NAD(P) binding site [chemical binding]; other site
662755001945	dimer interface [polypeptide binding]; other site
662755001946	malate binding site [chemical binding]; other site
662755001947	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
662755001948	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
662755001949	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
662755001950	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
662755001951	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
662755001952	active site
662755001953	HIGH motif; other site
662755001954	nucleotide binding site [chemical binding]; other site
662755001955	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
662755001956	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
662755001957	active site
662755001958	KMSKS motif; other site
662755001959	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
662755001960	tRNA binding surface [nucleotide binding]; other site
662755001961	anticodon binding site; other site
662755001962	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
662755001963	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
662755001964	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
662755001965	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
662755001966	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
662755001967	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
662755001968	active site
662755001969	multimer interface [polypeptide binding]; other site
662755001970	MULE transposase domain; Region: MULE; pfam10551
662755001971	META domain; Region: META; cl01245
662755001972	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
662755001973	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
662755001974	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
662755001975	homodimer interface [polypeptide binding]; other site
662755001976	oligonucleotide binding site [chemical binding]; other site
662755001977	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
662755001978	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
662755001979	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
662755001980	GTPase CgtA; Reviewed; Region: obgE; PRK12296
662755001981	GTP1/OBG; Region: GTP1_OBG; pfam01018
662755001982	Obg GTPase; Region: Obg; cd01898
662755001983	G1 box; other site
662755001984	GTP/Mg2+ binding site [chemical binding]; other site
662755001985	Switch I region; other site
662755001986	G2 box; other site
662755001987	G3 box; other site
662755001988	Switch II region; other site
662755001989	G4 box; other site
662755001990	G5 box; other site
662755001991	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
662755001992	gamma-glutamyl kinase; Provisional; Region: PRK05429
662755001993	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
662755001994	nucleotide binding site [chemical binding]; other site
662755001995	homotetrameric interface [polypeptide binding]; other site
662755001996	putative phosphate binding site [ion binding]; other site
662755001997	putative allosteric binding site; other site
662755001998	PUA domain; Region: PUA; pfam01472
662755001999	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
662755002000	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
662755002001	putative catalytic cysteine [active]
662755002002	YwiC-like protein; Region: YwiC; pfam14256
662755002003	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
662755002004	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
662755002005	active site
662755002006	(T/H)XGH motif; other site
662755002007	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
662755002008	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755002009	catalytic core [active]
662755002010	EDD domain protein, DegV family; Region: DegV; TIGR00762
662755002011	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
662755002012	SLBB domain; Region: SLBB; pfam10531
662755002013	comEA protein; Region: comE; TIGR01259
662755002014	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
662755002015	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
662755002016	Competence protein; Region: Competence; pfam03772
662755002017	hypothetical protein; Validated; Region: PRK05629
662755002018	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
662755002019	PemK-like protein; Region: PemK; cl00995
662755002020	GTP-binding protein LepA; Provisional; Region: PRK05433
662755002021	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
662755002022	G1 box; other site
662755002023	putative GEF interaction site [polypeptide binding]; other site
662755002024	GTP/Mg2+ binding site [chemical binding]; other site
662755002025	Switch I region; other site
662755002026	G2 box; other site
662755002027	G3 box; other site
662755002028	Switch II region; other site
662755002029	G4 box; other site
662755002030	G5 box; other site
662755002031	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
662755002032	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
662755002033	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
662755002034	Predicted membrane protein [Function unknown]; Region: COG1289
662755002035	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
662755002036	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
662755002037	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
662755002038	putative active site [active]
662755002039	putative metal binding site [ion binding]; other site
662755002040	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
662755002041	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
662755002042	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
662755002043	PYR/PP interface [polypeptide binding]; other site
662755002044	dimer interface [polypeptide binding]; other site
662755002045	TPP binding site [chemical binding]; other site
662755002046	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
662755002047	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
662755002048	TPP-binding site [chemical binding]; other site
662755002049	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
662755002050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755002051	ATP binding site [chemical binding]; other site
662755002052	putative Mg++ binding site [ion binding]; other site
662755002053	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755002054	nucleotide binding region [chemical binding]; other site
662755002055	ATP-binding site [chemical binding]; other site
662755002056	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
662755002057	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
662755002058	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
662755002059	dimer interface [polypeptide binding]; other site
662755002060	putative anticodon binding site; other site
662755002061	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
662755002062	motif 1; other site
662755002063	dimer interface [polypeptide binding]; other site
662755002064	active site
662755002065	motif 2; other site
662755002066	motif 3; other site
662755002067	BCCT family transporter; Region: BCCT; pfam02028
662755002068	Protein of unknown function (DUF3659); Region: DUF3659; pfam12396
662755002069	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
662755002070	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
662755002071	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
662755002072	CsbD-like; Region: CsbD; pfam05532
662755002073	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755002074	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
662755002075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755002076	Walker A/P-loop; other site
662755002077	ATP binding site [chemical binding]; other site
662755002078	Q-loop/lid; other site
662755002079	ABC transporter signature motif; other site
662755002080	Walker B; other site
662755002081	D-loop; other site
662755002082	H-loop/switch region; other site
662755002083	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
662755002084	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755002085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755002086	homodimer interface [polypeptide binding]; other site
662755002087	catalytic residue [active]
662755002088	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
662755002089	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
662755002090	substrate binding pocket [chemical binding]; other site
662755002091	catalytic triad [active]
662755002092	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
662755002093	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
662755002094	active site
662755002095	Zn binding site [ion binding]; other site
662755002096	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
662755002097	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
662755002098	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
662755002099	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
662755002100	acyl-activating enzyme (AAE) consensus motif; other site
662755002101	putative AMP binding site [chemical binding]; other site
662755002102	putative active site [active]
662755002103	putative CoA binding site [chemical binding]; other site
662755002104	coproporphyrinogen III oxidase; Validated; Region: PRK05628
662755002105	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
662755002106	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
662755002107	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
662755002108	HSP70 interaction site [polypeptide binding]; other site
662755002109	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
662755002110	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
662755002111	dimer interface [polypeptide binding]; other site
662755002112	RNA methyltransferase, RsmE family; Region: TIGR00046
662755002113	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
662755002114	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
662755002115	PhoH-like protein; Region: PhoH; pfam02562
662755002116	metal-binding heat shock protein; Provisional; Region: PRK00016
662755002117	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
662755002118	Domain of unknown function DUF21; Region: DUF21; pfam01595
662755002119	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
662755002120	Transporter associated domain; Region: CorC_HlyC; cl08393
662755002121	GTPase Era; Reviewed; Region: era; PRK00089
662755002122	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
662755002123	G1 box; other site
662755002124	GTP/Mg2+ binding site [chemical binding]; other site
662755002125	Switch I region; other site
662755002126	G2 box; other site
662755002127	Switch II region; other site
662755002128	G3 box; other site
662755002129	G4 box; other site
662755002130	G5 box; other site
662755002131	KH domain; Region: KH_2; pfam07650
662755002132	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
662755002133	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
662755002134	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
662755002135	Recombination protein O N terminal; Region: RecO_N; pfam11967
662755002136	Recombination protein O C terminal; Region: RecO_C; pfam02565
662755002137	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
662755002138	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
662755002139	catalytic residue [active]
662755002140	putative FPP diphosphate  binding site; other site
662755002141	putative FPP binding hydrophobic cleft; other site
662755002142	dimer interface [polypeptide binding]; other site
662755002143	putative IPP diphosphate binding site; other site
662755002144	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
662755002145	dinuclear metal binding motif [ion binding]; other site
662755002146	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
662755002147	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
662755002148	metal binding site 2 [ion binding]; metal-binding site
662755002149	putative DNA binding helix; other site
662755002150	metal binding site 1 [ion binding]; metal-binding site
662755002151	dimer interface [polypeptide binding]; other site
662755002152	structural Zn2+ binding site [ion binding]; other site
662755002153	MULE transposase domain; Region: MULE; pfam10551
662755002154	glycyl-tRNA synthetase; Provisional; Region: PRK04173
662755002155	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
662755002156	motif 1; other site
662755002157	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
662755002158	active site
662755002159	motif 2; other site
662755002160	motif 3; other site
662755002161	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
662755002162	anticodon binding site; other site
662755002163	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
662755002164	Uncharacterized conserved protein [Function unknown]; Region: COG1434
662755002165	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
662755002166	putative active site [active]
662755002167	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
662755002168	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
662755002169	Zn2+ binding site [ion binding]; other site
662755002170	Mg2+ binding site [ion binding]; other site
662755002171	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
662755002172	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
662755002173	active site
662755002174	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
662755002175	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
662755002176	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
662755002177	DNA primase; Validated; Region: dnaG; PRK05667
662755002178	CHC2 zinc finger; Region: zf-CHC2; pfam01807
662755002179	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
662755002180	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
662755002181	active site
662755002182	metal binding site [ion binding]; metal-binding site
662755002183	interdomain interaction site; other site
662755002184	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
662755002185	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
662755002186	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
662755002187	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
662755002188	NAD binding site [chemical binding]; other site
662755002189	catalytic Zn binding site [ion binding]; other site
662755002190	substrate binding site [chemical binding]; other site
662755002191	structural Zn binding site [ion binding]; other site
662755002192	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
662755002193	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
662755002194	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
662755002195	metal-binding site [ion binding]
662755002196	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
662755002197	MULE transposase domain; Region: MULE; pfam10551
662755002198	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
662755002199	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
662755002200	oligomer interface [polypeptide binding]; other site
662755002201	metal binding site [ion binding]; metal-binding site
662755002202	metal binding site [ion binding]; metal-binding site
662755002203	putative Cl binding site [ion binding]; other site
662755002204	basic sphincter; other site
662755002205	hydrophobic gate; other site
662755002206	periplasmic entrance; other site
662755002207	Fructosamine kinase; Region: Fructosamin_kin; cl17579
662755002208	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
662755002209	Beta-lactamase; Region: Beta-lactamase; pfam00144
662755002210	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
662755002211	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
662755002212	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
662755002213	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
662755002214	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
662755002215	dimer interface [polypeptide binding]; other site
662755002216	TPP-binding site [chemical binding]; other site
662755002217	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
662755002218	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
662755002219	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
662755002220	Low molecular weight phosphatase family; Region: LMWPc; cd00115
662755002221	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
662755002222	active site
662755002223	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
662755002224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
662755002225	active site
662755002226	motif I; other site
662755002227	motif II; other site
662755002228	Uncharacterized conserved protein [Function unknown]; Region: COG0327
662755002229	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
662755002230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
662755002231	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
662755002232	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
662755002233	Putative zinc ribbon domain; Region: DUF164; pfam02591
662755002234	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
662755002235	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
662755002236	RNA/DNA hybrid binding site [nucleotide binding]; other site
662755002237	active site
662755002238	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755002239	catalytic core [active]
662755002240	RNB domain; Region: RNB; pfam00773
662755002241	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
662755002242	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
662755002243	oligomerization interface [polypeptide binding]; other site
662755002244	active site
662755002245	metal binding site [ion binding]; metal-binding site
662755002246	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
662755002247	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
662755002248	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
662755002249	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
662755002250	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
662755002251	metal binding triad; other site
662755002252	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
662755002253	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
662755002254	metal binding triad; other site
662755002255	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
662755002256	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
662755002257	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
662755002258	aminotransferase; Validated; Region: PRK07777
662755002259	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755002260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755002261	homodimer interface [polypeptide binding]; other site
662755002262	catalytic residue [active]
662755002263	biotin synthase; Validated; Region: PRK06256
662755002264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
662755002265	FeS/SAM binding site; other site
662755002266	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
662755002267	Predicted membrane protein [Function unknown]; Region: COG1511
662755002268	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
662755002269	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
662755002270	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
662755002271	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
662755002272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
662755002273	Walker A/P-loop; other site
662755002274	ATP binding site [chemical binding]; other site
662755002275	ABC transporter signature motif; other site
662755002276	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
662755002277	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
662755002278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755002279	catalytic residue [active]
662755002280	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
662755002281	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
662755002282	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
662755002283	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
662755002284	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
662755002285	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
662755002286	carboxyltransferase (CT) interaction site; other site
662755002287	biotinylation site [posttranslational modification]; other site
662755002288	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
662755002289	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
662755002290	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
662755002291	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
662755002292	putative active site [active]
662755002293	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
662755002294	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
662755002295	FMN binding site [chemical binding]; other site
662755002296	active site
662755002297	substrate binding site [chemical binding]; other site
662755002298	catalytic residue [active]
662755002299	glutamine synthetase, type I; Region: GlnA; TIGR00653
662755002300	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
662755002301	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
662755002302	RDD family; Region: RDD; pfam06271
662755002303	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
662755002304	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
662755002305	lipoyl synthase; Provisional; Region: PRK05481
662755002306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
662755002307	FeS/SAM binding site; other site
662755002308	lipoate-protein ligase B; Provisional; Region: PRK14345
662755002309	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
662755002310	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
662755002311	E3 interaction surface; other site
662755002312	lipoyl attachment site [posttranslational modification]; other site
662755002313	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
662755002314	E3 interaction surface; other site
662755002315	lipoyl attachment site [posttranslational modification]; other site
662755002316	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
662755002317	E3 interaction surface; other site
662755002318	lipoyl attachment site [posttranslational modification]; other site
662755002319	e3 binding domain; Region: E3_binding; pfam02817
662755002320	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
662755002321	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
662755002322	multifunctional aminopeptidase A; Provisional; Region: PRK00913
662755002323	interface (dimer of trimers) [polypeptide binding]; other site
662755002324	Substrate-binding/catalytic site; other site
662755002325	Zn-binding sites [ion binding]; other site
662755002326	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
662755002327	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
662755002328	homodimer interface [polypeptide binding]; other site
662755002329	substrate-cofactor binding pocket; other site
662755002330	catalytic residue [active]
662755002331	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
662755002332	active site pocket [active]
662755002333	putative dimer interface [polypeptide binding]; other site
662755002334	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
662755002335	putative cataytic base [active]
662755002336	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
662755002337	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
662755002338	PspC domain; Region: PspC; pfam04024
662755002339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
662755002340	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
662755002341	ATP binding site [chemical binding]; other site
662755002342	Mg2+ binding site [ion binding]; other site
662755002343	G-X-G motif; other site
662755002344	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755002345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755002346	active site
662755002347	phosphorylation site [posttranslational modification]
662755002348	intermolecular recognition site; other site
662755002349	dimerization interface [polypeptide binding]; other site
662755002350	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755002351	DNA binding residues [nucleotide binding]
662755002352	dimerization interface [polypeptide binding]; other site
662755002353	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
662755002354	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
662755002355	active site
662755002356	dimer interface [polypeptide binding]; other site
662755002357	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
662755002358	Ligand Binding Site [chemical binding]; other site
662755002359	Molecular Tunnel; other site
662755002360	pyruvate dehydrogenase; Provisional; Region: PRK06546
662755002361	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
662755002362	PYR/PP interface [polypeptide binding]; other site
662755002363	dimer interface [polypeptide binding]; other site
662755002364	tetramer interface [polypeptide binding]; other site
662755002365	TPP binding site [chemical binding]; other site
662755002366	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
662755002367	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
662755002368	TPP-binding site [chemical binding]; other site
662755002369	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
662755002370	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
662755002371	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
662755002372	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
662755002373	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
662755002374	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
662755002375	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
662755002376	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
662755002377	Subunit I/III interface [polypeptide binding]; other site
662755002378	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
662755002379	cytochrome c-550; Provisional; Region: psbV; cl17239
662755002380	Cytochrome c; Region: Cytochrom_C; pfam00034
662755002381	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
662755002382	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
662755002383	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
662755002384	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
662755002385	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
662755002386	iron-sulfur cluster [ion binding]; other site
662755002387	[2Fe-2S] cluster binding site [ion binding]; other site
662755002388	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
662755002389	heme bH binding site [chemical binding]; other site
662755002390	intrachain domain interface; other site
662755002391	heme bL binding site [chemical binding]; other site
662755002392	interchain domain interface [polypeptide binding]; other site
662755002393	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
662755002394	Qo binding site; other site
662755002395	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
662755002396	active site
662755002397	catalytic site [active]
662755002398	substrate binding site [chemical binding]; other site
662755002399	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
662755002400	NlpC/P60 family; Region: NLPC_P60; pfam00877
662755002401	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
662755002402	NlpC/P60 family; Region: NLPC_P60; pfam00877
662755002403	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
662755002404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
662755002405	Predicted permease [General function prediction only]; Region: COG2985
662755002406	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
662755002407	TrkA-C domain; Region: TrkA_C; pfam02080
662755002408	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
662755002409	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
662755002410	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
662755002411	nucleotide binding site [chemical binding]; other site
662755002412	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
662755002413	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
662755002414	putative acyl-acceptor binding pocket; other site
662755002415	Predicted membrane protein [Function unknown]; Region: COG4763
662755002416	Acyltransferase family; Region: Acyl_transf_3; pfam01757
662755002417	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
662755002418	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
662755002419	Catalytic domain of Protein Kinases; Region: PKc; cd00180
662755002420	active site
662755002421	ATP binding site [chemical binding]; other site
662755002422	substrate binding site [chemical binding]; other site
662755002423	activation loop (A-loop); other site
662755002424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
662755002425	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755002426	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755002427	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755002428	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
662755002429	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
662755002430	phytoene desaturase; Region: crtI_fam; TIGR02734
662755002431	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
662755002432	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
662755002433	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
662755002434	substrate binding pocket [chemical binding]; other site
662755002435	chain length determination region; other site
662755002436	substrate-Mg2+ binding site; other site
662755002437	catalytic residues [active]
662755002438	aspartate-rich region 1; other site
662755002439	active site lid residues [active]
662755002440	aspartate-rich region 2; other site
662755002441	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
662755002442	FAD binding site [chemical binding]; other site
662755002443	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
662755002444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755002445	Coenzyme A binding pocket [chemical binding]; other site
662755002446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
662755002447	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
662755002448	MULE transposase domain; Region: MULE; pfam10551
662755002449	cell division protein MraZ; Reviewed; Region: PRK00326
662755002450	MraZ protein; Region: MraZ; pfam02381
662755002451	MraZ protein; Region: MraZ; pfam02381
662755002452	MraW methylase family; Region: Methyltransf_5; cl17771
662755002453	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
662755002454	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
662755002455	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
662755002456	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
662755002457	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
662755002458	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
662755002459	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
662755002460	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
662755002461	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
662755002462	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
662755002463	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
662755002464	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
662755002465	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
662755002466	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
662755002467	Mg++ binding site [ion binding]; other site
662755002468	putative catalytic motif [active]
662755002469	putative substrate binding site [chemical binding]; other site
662755002470	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
662755002471	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
662755002472	cell division protein FtsW; Region: ftsW; TIGR02614
662755002473	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
662755002474	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
662755002475	active site
662755002476	homodimer interface [polypeptide binding]; other site
662755002477	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
662755002478	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
662755002479	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
662755002480	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
662755002481	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
662755002482	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
662755002483	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
662755002484	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
662755002485	nucleotide binding site [chemical binding]; other site
662755002486	SulA interaction site; other site
662755002487	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
662755002488	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
662755002489	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
662755002490	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
662755002491	catalytic residue [active]
662755002492	Protein of unknown function (DUF552); Region: DUF552; pfam04472
662755002493	YGGT family; Region: YGGT; pfam02325
662755002494	DivIVA domain; Region: DivI1A_domain; TIGR03544
662755002495	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
662755002496	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
662755002497	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
662755002498	HIGH motif; other site
662755002499	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
662755002500	active site
662755002501	KMSKS motif; other site
662755002502	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
662755002503	tRNA binding surface [nucleotide binding]; other site
662755002504	anticodon binding site; other site
662755002505	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
662755002506	EamA-like transporter family; Region: EamA; pfam00892
662755002507	DNA polymerase IV; Provisional; Region: PRK03348
662755002508	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
662755002509	active site
662755002510	DNA binding site [nucleotide binding]
662755002511	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
662755002512	active site
662755002513	homotetramer interface [polypeptide binding]; other site
662755002514	homodimer interface [polypeptide binding]; other site
662755002515	lipoprotein signal peptidase; Provisional; Region: PRK14787
662755002516	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
662755002517	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
662755002518	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
662755002519	active site
662755002520	Predicted permeases [General function prediction only]; Region: RarD; COG2962
662755002521	EamA-like transporter family; Region: EamA; cl17759
662755002522	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
662755002523	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
662755002524	dimer interface [polypeptide binding]; other site
662755002525	active site
662755002526	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
662755002527	substrate binding site [chemical binding]; other site
662755002528	catalytic residue [active]
662755002529	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
662755002530	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
662755002531	active site
662755002532	PHP Thumb interface [polypeptide binding]; other site
662755002533	metal binding site [ion binding]; metal-binding site
662755002534	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
662755002535	generic binding surface II; other site
662755002536	generic binding surface I; other site
662755002537	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
662755002538	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
662755002539	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
662755002540	catalytic site [active]
662755002541	active site
662755002542	Uncharacterized conserved protein [Function unknown]; Region: COG1739
662755002543	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
662755002544	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
662755002545	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
662755002546	RNA binding surface [nucleotide binding]; other site
662755002547	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
662755002548	synthetase active site [active]
662755002549	NTP binding site [chemical binding]; other site
662755002550	metal binding site [ion binding]; metal-binding site
662755002551	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
662755002552	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
662755002553	active site
662755002554	catalytic site [active]
662755002555	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
662755002556	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
662755002557	Dimer interface [polypeptide binding]; other site
662755002558	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
662755002559	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
662755002560	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
662755002561	active site
662755002562	catalytic site [active]
662755002563	tetracycline repressor protein TetR; Provisional; Region: PRK13756
662755002564	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755002565	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
662755002566	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
662755002567	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
662755002568	NAD binding site [chemical binding]; other site
662755002569	dimerization interface [polypeptide binding]; other site
662755002570	product binding site; other site
662755002571	substrate binding site [chemical binding]; other site
662755002572	zinc binding site [ion binding]; other site
662755002573	catalytic residues [active]
662755002574	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
662755002575	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755002576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755002577	homodimer interface [polypeptide binding]; other site
662755002578	catalytic residue [active]
662755002579	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
662755002580	putative active site pocket [active]
662755002581	4-fold oligomerization interface [polypeptide binding]; other site
662755002582	metal binding residues [ion binding]; metal-binding site
662755002583	3-fold/trimer interface [polypeptide binding]; other site
662755002584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755002585	putative substrate translocation pore; other site
662755002586	Major Facilitator Superfamily; Region: MFS_1; pfam07690
662755002587	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
662755002588	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
662755002589	putative active site [active]
662755002590	oxyanion strand; other site
662755002591	catalytic triad [active]
662755002592	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
662755002593	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
662755002594	catalytic residues [active]
662755002595	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
662755002596	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
662755002597	active site
662755002598	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
662755002599	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
662755002600	substrate binding site [chemical binding]; other site
662755002601	glutamase interaction surface [polypeptide binding]; other site
662755002602	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
662755002603	anthranilate synthase component I; Provisional; Region: PRK13571
662755002604	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
662755002605	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
662755002606	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
662755002607	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
662755002608	active site
662755002609	ribulose/triose binding site [chemical binding]; other site
662755002610	phosphate binding site [ion binding]; other site
662755002611	substrate (anthranilate) binding pocket [chemical binding]; other site
662755002612	product (indole) binding pocket [chemical binding]; other site
662755002613	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
662755002614	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
662755002615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755002616	catalytic residue [active]
662755002617	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
662755002618	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
662755002619	substrate binding site [chemical binding]; other site
662755002620	active site
662755002621	catalytic residues [active]
662755002622	heterodimer interface [polypeptide binding]; other site
662755002623	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
662755002624	pyruvate kinase; Provisional; Region: PRK06247
662755002625	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
662755002626	domain interfaces; other site
662755002627	active site
662755002628	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
662755002629	amidohydrolase; Region: amidohydrolases; TIGR01891
662755002630	metal binding site [ion binding]; metal-binding site
662755002631	putative dimer interface [polypeptide binding]; other site
662755002632	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
662755002633	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
662755002634	active site
662755002635	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
662755002636	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
662755002637	Walker A/P-loop; other site
662755002638	ATP binding site [chemical binding]; other site
662755002639	Q-loop/lid; other site
662755002640	ABC transporter signature motif; other site
662755002641	Walker B; other site
662755002642	D-loop; other site
662755002643	H-loop/switch region; other site
662755002644	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
662755002645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755002646	dimer interface [polypeptide binding]; other site
662755002647	conserved gate region; other site
662755002648	putative PBP binding loops; other site
662755002649	ABC-ATPase subunit interface; other site
662755002650	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
662755002651	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
662755002652	substrate binding pocket [chemical binding]; other site
662755002653	membrane-bound complex binding site; other site
662755002654	hinge residues; other site
662755002655	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
662755002656	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
662755002657	DNA binding site [nucleotide binding]
662755002658	active site
662755002659	glutaminase; Provisional; Region: PRK00971
662755002660	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
662755002661	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
662755002662	anti sigma factor interaction site; other site
662755002663	regulatory phosphorylation site [posttranslational modification]; other site
662755002664	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
662755002665	pentamer interface [polypeptide binding]; other site
662755002666	dodecaamer interface [polypeptide binding]; other site
662755002667	Radical SAM superfamily; Region: Radical_SAM; pfam04055
662755002668	putative peptide-modifying radical SAM enzyme, Mhun_1560 family; Region: rSAM_pep_methan; TIGR04083
662755002669	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
662755002670	CAAX protease self-immunity; Region: Abi; pfam02517
662755002671	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
662755002672	putative substrate binding pocket [chemical binding]; other site
662755002673	AC domain interface; other site
662755002674	catalytic triad [active]
662755002675	AB domain interface; other site
662755002676	interchain disulfide; other site
662755002677	Predicted helicase [General function prediction only]; Region: COG4889
662755002678	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
662755002679	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
662755002680	catalytic residues [active]
662755002681	Recombinase; Region: Recombinase; pfam07508
662755002682	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
662755002683	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
662755002684	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
662755002685	catalytic residues [active]
662755002686	catalytic nucleophile [active]
662755002687	Recombinase; Region: Recombinase; pfam07508
662755002688	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
662755002689	GIY-YIG motif/motif A; other site
662755002690	putative active site [active]
662755002691	putative metal binding site [ion binding]; other site
662755002692	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
662755002693	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
662755002694	amidase catalytic site [active]
662755002695	Zn binding residues [ion binding]; other site
662755002696	substrate binding site [chemical binding]; other site
662755002697	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
662755002698	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
662755002699	Holin family; Region: Phage_holin_4; pfam05105
662755002700	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
662755002701	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
662755002702	Phage-related protein [Function unknown]; Region: COG4722
662755002703	Phage tail protein; Region: Sipho_tail; cl17486
662755002704	Phage-related protein [Function unknown]; Region: COG5412
662755002705	tape measure domain; Region: tape_meas_nterm; TIGR02675
662755002706	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
662755002707	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
662755002708	oligomerization interface [polypeptide binding]; other site
662755002709	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
662755002710	Phage capsid family; Region: Phage_capsid; pfam05065
662755002711	Clp protease; Region: CLP_protease; pfam00574
662755002712	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
662755002713	oligomer interface [polypeptide binding]; other site
662755002714	active site residues [active]
662755002715	Phage-related protein [Function unknown]; Region: COG4695
662755002716	Phage portal protein; Region: Phage_portal; pfam04860
662755002717	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
662755002718	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
662755002719	ParB-like nuclease domain; Region: ParBc; cl02129
662755002720	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
662755002721	DNA methylase; Region: N6_N4_Mtase; pfam01555
662755002722	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
662755002723	S-adenosylmethionine synthetase; Provisional; Region: PRK12459
662755002724	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
662755002725	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
662755002726	Phage terminase, small subunit; Region: Terminase_4; cl01525
662755002727	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
662755002728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755002729	ATP binding site [chemical binding]; other site
662755002730	putative Mg++ binding site [ion binding]; other site
662755002731	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
662755002732	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
662755002733	D5 N terminal like; Region: D5_N; pfam08706
662755002734	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
662755002735	Prophage antirepressor [Transcription]; Region: COG3617
662755002736	BRO family, N-terminal domain; Region: Bro-N; smart01040
662755002737	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
662755002738	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
662755002739	active site
662755002740	DNA binding site [nucleotide binding]
662755002741	catalytic site [active]
662755002742	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
662755002743	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
662755002744	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
662755002745	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755002746	DNA binding residues [nucleotide binding]
662755002747	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
662755002748	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
662755002749	DNA methylase; Region: N6_N4_Mtase; pfam01555
662755002750	DNA methylase; Region: N6_N4_Mtase; cl17433
662755002751	Restriction endonuclease [Defense mechanisms]; Region: COG3587
662755002752	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755002753	ATP binding site [chemical binding]; other site
662755002754	putative Mg++ binding site [ion binding]; other site
662755002755	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755002756	ATP binding site [chemical binding]; other site
662755002757	putative Mg++ binding site [ion binding]; other site
662755002758	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
662755002759	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755002760	nucleotide binding region [chemical binding]; other site
662755002761	ATP-binding site [chemical binding]; other site
662755002762	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
662755002763	Predicted helicase [General function prediction only]; Region: COG4889
662755002764	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
662755002765	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755002766	ATP binding site [chemical binding]; other site
662755002767	putative Mg++ binding site [ion binding]; other site
662755002768	helicase superfamily c-terminal domain; Region: HELICc; smart00490
662755002769	ATP-binding site [chemical binding]; other site
662755002770	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
662755002771	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
662755002772	active site
662755002773	catalytic site [active]
662755002774	substrate binding site [chemical binding]; other site
662755002775	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755002776	DNA binding residues [nucleotide binding]
662755002777	DNA polymerase I; Provisional; Region: PRK05755
662755002778	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
662755002779	active site
662755002780	metal binding site 1 [ion binding]; metal-binding site
662755002781	putative 5' ssDNA interaction site; other site
662755002782	metal binding site 3; metal-binding site
662755002783	metal binding site 2 [ion binding]; metal-binding site
662755002784	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
662755002785	putative DNA binding site [nucleotide binding]; other site
662755002786	putative metal binding site [ion binding]; other site
662755002787	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
662755002788	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
662755002789	active site
662755002790	DNA binding site [nucleotide binding]
662755002791	catalytic site [active]
662755002792	Domain of unknown function (DUF368); Region: DUF368; pfam04018
662755002793	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
662755002794	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
662755002795	RNA binding site [nucleotide binding]; other site
662755002796	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
662755002797	RNA binding site [nucleotide binding]; other site
662755002798	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
662755002799	RNA binding site [nucleotide binding]; other site
662755002800	S1 RNA binding domain; Region: S1; pfam00575
662755002801	RNA binding site [nucleotide binding]; other site
662755002802	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
662755002803	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
662755002804	active site
662755002805	catalytic site [active]
662755002806	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
662755002807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755002808	NAD(P) binding site [chemical binding]; other site
662755002809	active site
662755002810	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
662755002811	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
662755002812	dimer interface [polypeptide binding]; other site
662755002813	active site
662755002814	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
662755002815	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
662755002816	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
662755002817	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
662755002818	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
662755002819	CoA-binding site [chemical binding]; other site
662755002820	ATP-binding [chemical binding]; other site
662755002821	excinuclease ABC subunit B; Provisional; Region: PRK05298
662755002822	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755002823	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755002824	nucleotide binding region [chemical binding]; other site
662755002825	ATP-binding site [chemical binding]; other site
662755002826	Ultra-violet resistance protein B; Region: UvrB; pfam12344
662755002827	UvrB/uvrC motif; Region: UVR; pfam02151
662755002828	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
662755002829	Ligand Binding Site [chemical binding]; other site
662755002830	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
662755002831	Part of AAA domain; Region: AAA_19; pfam13245
662755002832	Family description; Region: UvrD_C_2; pfam13538
662755002833	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
662755002834	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
662755002835	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
662755002836	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
662755002837	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
662755002838	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
662755002839	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
662755002840	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
662755002841	23S rRNA binding site [nucleotide binding]; other site
662755002842	L21 binding site [polypeptide binding]; other site
662755002843	L13 binding site [polypeptide binding]; other site
662755002844	TM2 domain; Region: TM2; pfam05154
662755002845	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
662755002846	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
662755002847	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
662755002848	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
662755002849	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
662755002850	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
662755002851	dimer interface [polypeptide binding]; other site
662755002852	motif 1; other site
662755002853	active site
662755002854	motif 2; other site
662755002855	motif 3; other site
662755002856	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
662755002857	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
662755002858	putative tRNA-binding site [nucleotide binding]; other site
662755002859	B3/4 domain; Region: B3_4; pfam03483
662755002860	tRNA synthetase B5 domain; Region: B5; smart00874
662755002861	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
662755002862	dimer interface [polypeptide binding]; other site
662755002863	motif 1; other site
662755002864	motif 3; other site
662755002865	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
662755002866	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
662755002867	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
662755002868	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
662755002869	heterotetramer interface [polypeptide binding]; other site
662755002870	active site pocket [active]
662755002871	cleavage site
662755002872	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
662755002873	feedback inhibition sensing region; other site
662755002874	homohexameric interface [polypeptide binding]; other site
662755002875	nucleotide binding site [chemical binding]; other site
662755002876	N-acetyl-L-glutamate binding site [chemical binding]; other site
662755002877	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
662755002878	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
662755002879	inhibitor-cofactor binding pocket; inhibition site
662755002880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755002881	catalytic residue [active]
662755002882	ornithine carbamoyltransferase; Provisional; Region: PRK00779
662755002883	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
662755002884	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
662755002885	arginine repressor; Region: argR_whole; TIGR01529
662755002886	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
662755002887	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
662755002888	argininosuccinate synthase; Provisional; Region: PRK13820
662755002889	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
662755002890	ANP binding site [chemical binding]; other site
662755002891	Substrate Binding Site II [chemical binding]; other site
662755002892	Substrate Binding Site I [chemical binding]; other site
662755002893	argininosuccinate lyase; Provisional; Region: PRK00855
662755002894	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
662755002895	active sites [active]
662755002896	tetramer interface [polypeptide binding]; other site
662755002897	thiamine biosynthesis protein ThiF; Validated; Region: PRK05600
662755002898	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
662755002899	ATP binding site [chemical binding]; other site
662755002900	substrate interface [chemical binding]; other site
662755002901	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
662755002902	active site residue [active]
662755002903	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
662755002904	ThiS interaction site; other site
662755002905	putative active site [active]
662755002906	tetramer interface [polypeptide binding]; other site
662755002907	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
662755002908	thiS-thiF/thiG interaction site; other site
662755002909	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
662755002910	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
662755002911	active site
662755002912	thiamine phosphate binding site [chemical binding]; other site
662755002913	pyrophosphate binding site [ion binding]; other site
662755002914	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
662755002915	ThiC-associated domain; Region: ThiC-associated; pfam13667
662755002916	ThiC family; Region: ThiC; pfam01964
662755002917	Uncharacterized conserved protein [Function unknown]; Region: COG2835
662755002918	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
662755002919	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
662755002920	active site
662755002921	HIGH motif; other site
662755002922	dimer interface [polypeptide binding]; other site
662755002923	KMSKS motif; other site
662755002924	S4 RNA-binding domain; Region: S4; smart00363
662755002925	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
662755002926	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
662755002927	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
662755002928	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
662755002929	Walker A/P-loop; other site
662755002930	ATP binding site [chemical binding]; other site
662755002931	Q-loop/lid; other site
662755002932	ABC transporter signature motif; other site
662755002933	Walker B; other site
662755002934	D-loop; other site
662755002935	H-loop/switch region; other site
662755002936	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
662755002937	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
662755002938	Walker A/P-loop; other site
662755002939	ATP binding site [chemical binding]; other site
662755002940	Q-loop/lid; other site
662755002941	ABC transporter signature motif; other site
662755002942	Walker B; other site
662755002943	D-loop; other site
662755002944	H-loop/switch region; other site
662755002945	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
662755002946	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
662755002947	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
662755002948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755002949	dimer interface [polypeptide binding]; other site
662755002950	conserved gate region; other site
662755002951	putative PBP binding loops; other site
662755002952	ABC-ATPase subunit interface; other site
662755002953	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
662755002954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755002955	dimer interface [polypeptide binding]; other site
662755002956	conserved gate region; other site
662755002957	putative PBP binding loops; other site
662755002958	ABC-ATPase subunit interface; other site
662755002959	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
662755002960	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
662755002961	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
662755002962	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
662755002963	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
662755002964	RNA binding surface [nucleotide binding]; other site
662755002965	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
662755002966	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
662755002967	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
662755002968	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
662755002969	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
662755002970	Walker A/P-loop; other site
662755002971	ATP binding site [chemical binding]; other site
662755002972	Q-loop/lid; other site
662755002973	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755002974	Walker B; other site
662755002975	D-loop; other site
662755002976	H-loop/switch region; other site
662755002977	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
662755002978	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
662755002979	CTP synthetase; Validated; Region: pyrG; PRK05380
662755002980	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
662755002981	Catalytic site [active]
662755002982	active site
662755002983	UTP binding site [chemical binding]; other site
662755002984	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
662755002985	active site
662755002986	putative oxyanion hole; other site
662755002987	catalytic triad [active]
662755002988	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
662755002989	dimer interface [polypeptide binding]; other site
662755002990	ADP-ribose binding site [chemical binding]; other site
662755002991	active site
662755002992	nudix motif; other site
662755002993	metal binding site [ion binding]; metal-binding site
662755002994	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
662755002995	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
662755002996	active site
662755002997	DNA binding site [nucleotide binding]
662755002998	Int/Topo IB signature motif; other site
662755002999	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
662755003000	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
662755003001	P-loop; other site
662755003002	Magnesium ion binding site [ion binding]; other site
662755003003	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
662755003004	Magnesium ion binding site [ion binding]; other site
662755003005	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
662755003006	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
662755003007	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
662755003008	active site
662755003009	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
662755003010	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
662755003011	RNA binding surface [nucleotide binding]; other site
662755003012	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
662755003013	active site
662755003014	cytidylate kinase; Provisional; Region: cmk; PRK00023
662755003015	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
662755003016	CMP-binding site; other site
662755003017	The sites determining sugar specificity; other site
662755003018	GTP-binding protein Der; Reviewed; Region: PRK03003
662755003019	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
662755003020	G1 box; other site
662755003021	GTP/Mg2+ binding site [chemical binding]; other site
662755003022	Switch I region; other site
662755003023	G2 box; other site
662755003024	Switch II region; other site
662755003025	G3 box; other site
662755003026	G4 box; other site
662755003027	G5 box; other site
662755003028	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
662755003029	G1 box; other site
662755003030	GTP/Mg2+ binding site [chemical binding]; other site
662755003031	Switch I region; other site
662755003032	G2 box; other site
662755003033	G3 box; other site
662755003034	Switch II region; other site
662755003035	G4 box; other site
662755003036	G5 box; other site
662755003037	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
662755003038	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
662755003039	Potassium binding sites [ion binding]; other site
662755003040	Cesium cation binding sites [ion binding]; other site
662755003041	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
662755003042	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
662755003043	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
662755003044	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
662755003045	Putative esterase; Region: Esterase; pfam00756
662755003046	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
662755003047	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
662755003048	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
662755003049	active site
662755003050	active site
662755003051	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
662755003052	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
662755003053	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
662755003054	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
662755003055	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
662755003056	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
662755003057	phosphopeptide binding site; other site
662755003058	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
662755003059	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
662755003060	DNA binding residues [nucleotide binding]
662755003061	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
662755003062	DNA binding residues [nucleotide binding]
662755003063	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
662755003064	putative dimer interface [polypeptide binding]; other site
662755003065	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
662755003066	metal ion-dependent adhesion site (MIDAS); other site
662755003067	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
662755003068	Domain of unknown function DUF21; Region: DUF21; pfam01595
662755003069	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
662755003070	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
662755003071	Domain of unknown function DUF21; Region: DUF21; pfam01595
662755003072	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
662755003073	Transporter associated domain; Region: CorC_HlyC; smart01091
662755003074	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
662755003075	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
662755003076	ATP binding site [chemical binding]; other site
662755003077	putative Mg++ binding site [ion binding]; other site
662755003078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755003079	nucleotide binding region [chemical binding]; other site
662755003080	ATP-binding site [chemical binding]; other site
662755003081	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
662755003082	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
662755003083	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
662755003084	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
662755003085	CoenzymeA binding site [chemical binding]; other site
662755003086	subunit interaction site [polypeptide binding]; other site
662755003087	PHB binding site; other site
662755003088	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
662755003089	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
662755003090	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
662755003091	metabolite-proton symporter; Region: 2A0106; TIGR00883
662755003092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755003093	putative substrate translocation pore; other site
662755003094	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
662755003095	FAD binding domain; Region: FAD_binding_2; pfam00890
662755003096	Amidase; Region: Amidase; cl11426
662755003097	amidase; Provisional; Region: PRK12470
662755003098	Secretory lipase; Region: LIP; pfam03583
662755003099	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
662755003100	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
662755003101	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
662755003102	TrkA-N domain; Region: TrkA_N; pfam02254
662755003103	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
662755003104	MgtE intracellular N domain; Region: MgtE_N; pfam03448
662755003105	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
662755003106	Divalent cation transporter; Region: MgtE; pfam01769
662755003107	YceI-like domain; Region: YceI; pfam04264
662755003108	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
662755003109	Integrase core domain; Region: rve; pfam00665
662755003110	Integrase core domain; Region: rve_2; pfam13333
662755003111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
662755003112	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755003113	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
662755003114	Ligand binding site; other site
662755003115	Putative Catalytic site; other site
662755003116	DXD motif; other site
662755003117	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
662755003118	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
662755003119	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
662755003120	putative active site [active]
662755003121	catalytic triad [active]
662755003122	putative dimer interface [polypeptide binding]; other site
662755003123	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
662755003124	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
662755003125	classical (c) SDRs; Region: SDR_c; cd05233
662755003126	NAD(P) binding site [chemical binding]; other site
662755003127	active site
662755003128	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755003129	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
662755003130	ATP binding site [chemical binding]; other site
662755003131	putative Mg++ binding site [ion binding]; other site
662755003132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755003133	nucleotide binding region [chemical binding]; other site
662755003134	ATP-binding site [chemical binding]; other site
662755003135	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
662755003136	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
662755003137	WYL domain; Region: WYL; pfam13280
662755003138	Predicted transcriptional regulator [Transcription]; Region: COG2378
662755003139	WYL domain; Region: WYL; pfam13280
662755003140	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
662755003141	Pup-like protein; Region: Pup; pfam05639
662755003142	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
662755003143	proteasome ATPase; Region: pup_AAA; TIGR03689
662755003144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755003145	Walker A motif; other site
662755003146	ATP binding site [chemical binding]; other site
662755003147	Walker B motif; other site
662755003148	arginine finger; other site
662755003149	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
662755003150	active site
662755003151	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
662755003152	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
662755003153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755003154	S-adenosylmethionine binding site [chemical binding]; other site
662755003155	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
662755003156	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
662755003157	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
662755003158	Aspartase; Region: Aspartase; cd01357
662755003159	active sites [active]
662755003160	tetramer interface [polypeptide binding]; other site
662755003161	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
662755003162	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
662755003163	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
662755003164	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
662755003165	homodimer interface [polypeptide binding]; other site
662755003166	putative metal binding site [ion binding]; other site
662755003167	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
662755003168	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
662755003169	motif I; other site
662755003170	active site
662755003171	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
662755003172	motif II; other site
662755003173	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
662755003174	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
662755003175	CoenzymeA binding site [chemical binding]; other site
662755003176	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
662755003177	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
662755003178	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
662755003179	substrate binding pocket [chemical binding]; other site
662755003180	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
662755003181	B12 binding site [chemical binding]; other site
662755003182	cobalt ligand [ion binding]; other site
662755003183	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
662755003184	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
662755003185	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
662755003186	active site
662755003187	HIGH motif; other site
662755003188	nucleotide binding site [chemical binding]; other site
662755003189	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
662755003190	active site
662755003191	KMSKS motif; other site
662755003192	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
662755003193	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
662755003194	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
662755003195	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
662755003196	quinone interaction residues [chemical binding]; other site
662755003197	active site
662755003198	catalytic residues [active]
662755003199	FMN binding site [chemical binding]; other site
662755003200	substrate binding site [chemical binding]; other site
662755003201	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
662755003202	substrate binding site [chemical binding]; other site
662755003203	Uncharacterized conserved protein [Function unknown]; Region: COG0398
662755003204	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
662755003205	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
662755003206	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
662755003207	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
662755003208	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
662755003209	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
662755003210	NlpC/P60 family; Region: NLPC_P60; pfam00877
662755003211	aconitate hydratase; Validated; Region: PRK09277
662755003212	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
662755003213	substrate binding site [chemical binding]; other site
662755003214	ligand binding site [chemical binding]; other site
662755003215	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
662755003216	substrate binding site [chemical binding]; other site
662755003217	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
662755003218	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755003219	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
662755003220	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
662755003221	AsnC family; Region: AsnC_trans_reg; pfam01037
662755003222	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
662755003223	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
662755003224	dimer interface [polypeptide binding]; other site
662755003225	PYR/PP interface [polypeptide binding]; other site
662755003226	TPP binding site [chemical binding]; other site
662755003227	substrate binding site [chemical binding]; other site
662755003228	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
662755003229	TPP-binding site; other site
662755003230	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
662755003231	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
662755003232	catalytic triad [active]
662755003233	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
662755003234	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
662755003235	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
662755003236	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755003237	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755003238	Walker A/P-loop; other site
662755003239	ATP binding site [chemical binding]; other site
662755003240	Q-loop/lid; other site
662755003241	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755003242	ABC transporter signature motif; other site
662755003243	Walker B; other site
662755003244	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755003245	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
662755003246	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
662755003247	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
662755003248	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
662755003249	trimerization site [polypeptide binding]; other site
662755003250	active site
662755003251	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
662755003252	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
662755003253	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
662755003254	catalytic residue [active]
662755003255	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
662755003256	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
662755003257	Walker A/P-loop; other site
662755003258	ATP binding site [chemical binding]; other site
662755003259	Q-loop/lid; other site
662755003260	ABC transporter signature motif; other site
662755003261	Walker B; other site
662755003262	D-loop; other site
662755003263	H-loop/switch region; other site
662755003264	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
662755003265	FeS assembly protein SufD; Region: sufD; TIGR01981
662755003266	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
662755003267	FeS assembly protein SufB; Region: sufB; TIGR01980
662755003268	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
662755003269	dimerization interface [polypeptide binding]; other site
662755003270	putative DNA binding site [nucleotide binding]; other site
662755003271	Predicted transcriptional regulator [Transcription]; Region: COG2345
662755003272	putative Zn2+ binding site [ion binding]; other site
662755003273	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
662755003274	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
662755003275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755003276	ABC transporter signature motif; other site
662755003277	Walker B; other site
662755003278	D-loop; other site
662755003279	H-loop/switch region; other site
662755003280	ABC-2 type transporter; Region: ABC2_membrane; cl17235
662755003281	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
662755003282	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
662755003283	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
662755003284	UbiA prenyltransferase family; Region: UbiA; pfam01040
662755003285	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
662755003286	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
662755003287	TPP-binding site [chemical binding]; other site
662755003288	dimer interface [polypeptide binding]; other site
662755003289	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
662755003290	PYR/PP interface [polypeptide binding]; other site
662755003291	dimer interface [polypeptide binding]; other site
662755003292	TPP binding site [chemical binding]; other site
662755003293	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
662755003294	putative active site [active]
662755003295	transaldolase; Provisional; Region: PRK03903
662755003296	catalytic residue [active]
662755003297	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
662755003298	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
662755003299	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
662755003300	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
662755003301	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
662755003302	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
662755003303	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
662755003304	putative active site [active]
662755003305	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
662755003306	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
662755003307	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
662755003308	substrate binding site [chemical binding]; other site
662755003309	dimer interface [polypeptide binding]; other site
662755003310	catalytic triad [active]
662755003311	Phosphoglycerate kinase; Region: PGK; pfam00162
662755003312	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
662755003313	substrate binding site [chemical binding]; other site
662755003314	hinge regions; other site
662755003315	ADP binding site [chemical binding]; other site
662755003316	catalytic site [active]
662755003317	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
662755003318	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
662755003319	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
662755003320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
662755003321	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
662755003322	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
662755003323	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
662755003324	phosphate binding site [ion binding]; other site
662755003325	putative substrate binding pocket [chemical binding]; other site
662755003326	dimer interface [polypeptide binding]; other site
662755003327	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
662755003328	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
662755003329	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
662755003330	GIY-YIG motif/motif A; other site
662755003331	active site
662755003332	catalytic site [active]
662755003333	putative DNA binding site [nucleotide binding]; other site
662755003334	metal binding site [ion binding]; metal-binding site
662755003335	UvrB/uvrC motif; Region: UVR; pfam02151
662755003336	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
662755003337	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
662755003338	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
662755003339	homopentamer interface [polypeptide binding]; other site
662755003340	active site
662755003341	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
662755003342	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
662755003343	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
662755003344	dimerization interface [polypeptide binding]; other site
662755003345	active site
662755003346	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
662755003347	Lumazine binding domain; Region: Lum_binding; pfam00677
662755003348	Lumazine binding domain; Region: Lum_binding; pfam00677
662755003349	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
662755003350	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
662755003351	catalytic motif [active]
662755003352	Zn binding site [ion binding]; other site
662755003353	RibD C-terminal domain; Region: RibD_C; cl17279
662755003354	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
662755003355	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
662755003356	substrate binding site [chemical binding]; other site
662755003357	hexamer interface [polypeptide binding]; other site
662755003358	metal binding site [ion binding]; metal-binding site
662755003359	16S rRNA methyltransferase B; Provisional; Region: PRK14902
662755003360	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
662755003361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755003362	S-adenosylmethionine binding site [chemical binding]; other site
662755003363	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
662755003364	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
662755003365	putative active site [active]
662755003366	substrate binding site [chemical binding]; other site
662755003367	putative cosubstrate binding site; other site
662755003368	catalytic site [active]
662755003369	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
662755003370	substrate binding site [chemical binding]; other site
662755003371	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
662755003372	active site
662755003373	catalytic residues [active]
662755003374	metal binding site [ion binding]; metal-binding site
662755003375	primosome assembly protein PriA; Provisional; Region: PRK14873
662755003376	S-adenosylmethionine synthetase; Validated; Region: PRK05250
662755003377	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
662755003378	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
662755003379	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
662755003380	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
662755003381	Flavoprotein; Region: Flavoprotein; pfam02441
662755003382	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
662755003383	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
662755003384	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
662755003385	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
662755003386	catalytic site [active]
662755003387	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
662755003388	active site
662755003389	dimer interface [polypeptide binding]; other site
662755003390	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
662755003391	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
662755003392	ATP-grasp domain; Region: ATP-grasp_4; cl17255
662755003393	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
662755003394	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
662755003395	ATP-grasp domain; Region: ATP-grasp_4; cl17255
662755003396	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
662755003397	IMP binding site; other site
662755003398	dimer interface [polypeptide binding]; other site
662755003399	interdomain contacts; other site
662755003400	partial ornithine binding site; other site
662755003401	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
662755003402	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
662755003403	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
662755003404	catalytic site [active]
662755003405	subunit interface [polypeptide binding]; other site
662755003406	dihydroorotase; Validated; Region: pyrC; PRK09357
662755003407	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
662755003408	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
662755003409	active site
662755003410	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
662755003411	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
662755003412	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
662755003413	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
662755003414	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
662755003415	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
662755003416	putative RNA binding site [nucleotide binding]; other site
662755003417	elongation factor P; Validated; Region: PRK00529
662755003418	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
662755003419	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
662755003420	RNA binding site [nucleotide binding]; other site
662755003421	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
662755003422	RNA binding site [nucleotide binding]; other site
662755003423	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
662755003424	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
662755003425	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
662755003426	active site
662755003427	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
662755003428	Dehydroquinase class II; Region: DHquinase_II; pfam01220
662755003429	trimer interface [polypeptide binding]; other site
662755003430	active site
662755003431	dimer interface [polypeptide binding]; other site
662755003432	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
662755003433	active site
662755003434	dimer interface [polypeptide binding]; other site
662755003435	metal binding site [ion binding]; metal-binding site
662755003436	shikimate kinase; Reviewed; Region: aroK; PRK00131
662755003437	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
662755003438	ADP binding site [chemical binding]; other site
662755003439	magnesium binding site [ion binding]; other site
662755003440	putative shikimate binding site; other site
662755003441	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
662755003442	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
662755003443	Tetramer interface [polypeptide binding]; other site
662755003444	active site
662755003445	FMN-binding site [chemical binding]; other site
662755003446	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
662755003447	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
662755003448	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
662755003449	shikimate binding site; other site
662755003450	NAD(P) binding site [chemical binding]; other site
662755003451	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
662755003452	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
662755003453	dimerization interface [polypeptide binding]; other site
662755003454	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
662755003455	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
662755003456	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
662755003457	motif 1; other site
662755003458	active site
662755003459	motif 2; other site
662755003460	motif 3; other site
662755003461	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
662755003462	DHHA1 domain; Region: DHHA1; pfam02272
662755003463	recombination factor protein RarA; Reviewed; Region: PRK13342
662755003464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755003465	Walker A motif; other site
662755003466	ATP binding site [chemical binding]; other site
662755003467	Walker B motif; other site
662755003468	arginine finger; other site
662755003469	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
662755003470	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
662755003471	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
662755003472	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
662755003473	dimer interface [polypeptide binding]; other site
662755003474	anticodon binding site; other site
662755003475	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
662755003476	homodimer interface [polypeptide binding]; other site
662755003477	motif 1; other site
662755003478	active site
662755003479	motif 2; other site
662755003480	GAD domain; Region: GAD; pfam02938
662755003481	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
662755003482	active site
662755003483	motif 3; other site
662755003484	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
662755003485	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
662755003486	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
662755003487	generic binding surface II; other site
662755003488	generic binding surface I; other site
662755003489	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
662755003490	putative active site [active]
662755003491	putative catalytic site [active]
662755003492	putative Mg binding site IVb [ion binding]; other site
662755003493	putative phosphate binding site [ion binding]; other site
662755003494	putative DNA binding site [nucleotide binding]; other site
662755003495	putative Mg binding site IVa [ion binding]; other site
662755003496	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
662755003497	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
662755003498	putative active site [active]
662755003499	putative metal binding site [ion binding]; other site
662755003500	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
662755003501	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
662755003502	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
662755003503	dimer interface [polypeptide binding]; other site
662755003504	motif 1; other site
662755003505	active site
662755003506	motif 2; other site
662755003507	motif 3; other site
662755003508	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
662755003509	anticodon binding site; other site
662755003510	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
662755003511	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
662755003512	active site
662755003513	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
662755003514	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
662755003515	Zn2+ binding site [ion binding]; other site
662755003516	Mg2+ binding site [ion binding]; other site
662755003517	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
662755003518	synthetase active site [active]
662755003519	NTP binding site [chemical binding]; other site
662755003520	metal binding site [ion binding]; metal-binding site
662755003521	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
662755003522	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
662755003523	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755003524	active site
662755003525	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
662755003526	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
662755003527	Protein export membrane protein; Region: SecD_SecF; cl14618
662755003528	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
662755003529	Protein export membrane protein; Region: SecD_SecF; pfam02355
662755003530	Preprotein translocase subunit; Region: YajC; pfam02699
662755003531	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
662755003532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755003533	Walker A motif; other site
662755003534	ATP binding site [chemical binding]; other site
662755003535	Walker B motif; other site
662755003536	arginine finger; other site
662755003537	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
662755003538	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
662755003539	RuvA N terminal domain; Region: RuvA_N; pfam01330
662755003540	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
662755003541	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
662755003542	active site
662755003543	putative DNA-binding cleft [nucleotide binding]; other site
662755003544	dimer interface [polypeptide binding]; other site
662755003545	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
662755003546	hypothetical protein; Validated; Region: PRK00110
662755003547	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
662755003548	predicted active site [active]
662755003549	catalytic triad [active]
662755003550	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
662755003551	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
662755003552	active site
662755003553	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
662755003554	catalytic triad [active]
662755003555	dimer interface [polypeptide binding]; other site
662755003556	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
662755003557	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
662755003558	active site
662755003559	multimer interface [polypeptide binding]; other site
662755003560	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
662755003561	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
662755003562	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
662755003563	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
662755003564	putative acyl-acceptor binding pocket; other site
662755003565	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
662755003566	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
662755003567	nucleotide binding site/active site [active]
662755003568	HIT family signature motif; other site
662755003569	catalytic residue [active]
662755003570	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
662755003571	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
662755003572	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
662755003573	active site
662755003574	dimer interface [polypeptide binding]; other site
662755003575	motif 1; other site
662755003576	motif 2; other site
662755003577	motif 3; other site
662755003578	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
662755003579	anticodon binding site; other site
662755003580	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
662755003581	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
662755003582	Protein of unknown function (DUF461); Region: DUF461; pfam04314
662755003583	CopC domain; Region: CopC; pfam04234
662755003584	potential frameshift: common BLAST hit: gi|257067717|ref|YP_003153972.1| transposase
662755003585	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
662755003586	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
662755003587	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755003588	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
662755003589	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
662755003590	NAD binding site [chemical binding]; other site
662755003591	substrate binding site [chemical binding]; other site
662755003592	catalytic Zn binding site [ion binding]; other site
662755003593	tetramer interface [polypeptide binding]; other site
662755003594	structural Zn binding site [ion binding]; other site
662755003595	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
662755003596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
662755003597	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
662755003598	MULE transposase domain; Region: MULE; pfam10551
662755003599	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
662755003600	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
662755003601	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
662755003602	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
662755003603	substrate binding site [chemical binding]; other site
662755003604	active site
662755003605	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
662755003606	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
662755003607	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
662755003608	catalytic site [active]
662755003609	putative active site [active]
662755003610	putative substrate binding site [chemical binding]; other site
662755003611	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
662755003612	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
662755003613	TPP-binding site; other site
662755003614	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
662755003615	PYR/PP interface [polypeptide binding]; other site
662755003616	dimer interface [polypeptide binding]; other site
662755003617	TPP binding site [chemical binding]; other site
662755003618	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
662755003619	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
662755003620	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
662755003621	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
662755003622	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
662755003623	trimer interface [polypeptide binding]; other site
662755003624	active site
662755003625	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
662755003626	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
662755003627	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
662755003628	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
662755003629	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
662755003630	active site
662755003631	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
662755003632	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
662755003633	nucleotide binding site [chemical binding]; other site
662755003634	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
662755003635	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
662755003636	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755003637	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
662755003638	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755003639	DNA binding residues [nucleotide binding]
662755003640	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
662755003641	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
662755003642	ATP binding site [chemical binding]; other site
662755003643	putative Mg++ binding site [ion binding]; other site
662755003644	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
662755003645	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
662755003646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755003647	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
662755003648	dimerization interface [polypeptide binding]; other site
662755003649	putative tRNAtyr binding site [nucleotide binding]; other site
662755003650	putative active site [active]
662755003651	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
662755003652	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
662755003653	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755003654	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
662755003655	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755003656	DNA binding residues [nucleotide binding]
662755003657	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
662755003658	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
662755003659	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
662755003660	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
662755003661	PAC2 family; Region: PAC2; pfam09754
662755003662	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755003663	ATP binding site [chemical binding]; other site
662755003664	putative Mg++ binding site [ion binding]; other site
662755003665	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755003666	nucleotide binding region [chemical binding]; other site
662755003667	ATP-binding site [chemical binding]; other site
662755003668	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
662755003669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
662755003670	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
662755003671	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
662755003672	dimerization interface [polypeptide binding]; other site
662755003673	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
662755003674	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
662755003675	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755003676	ATP binding site [chemical binding]; other site
662755003677	putative Mg++ binding site [ion binding]; other site
662755003678	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755003679	nucleotide binding region [chemical binding]; other site
662755003680	ATP-binding site [chemical binding]; other site
662755003681	Helicase associated domain (HA2); Region: HA2; pfam04408
662755003682	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
662755003683	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
662755003684	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
662755003685	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
662755003686	ATP cone domain; Region: ATP-cone; pfam03477
662755003687	LexA repressor; Validated; Region: PRK00215
662755003688	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
662755003689	putative DNA binding site [nucleotide binding]; other site
662755003690	putative Zn2+ binding site [ion binding]; other site
662755003691	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
662755003692	Catalytic site [active]
662755003693	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
662755003694	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
662755003695	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
662755003696	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
662755003697	GTPases [General function prediction only]; Region: HflX; COG2262
662755003698	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
662755003699	HflX GTPase family; Region: HflX; cd01878
662755003700	G1 box; other site
662755003701	GTP/Mg2+ binding site [chemical binding]; other site
662755003702	Switch I region; other site
662755003703	G2 box; other site
662755003704	G3 box; other site
662755003705	Switch II region; other site
662755003706	G4 box; other site
662755003707	G5 box; other site
662755003708	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
662755003709	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
662755003710	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
662755003711	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
662755003712	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
662755003713	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
662755003714	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
662755003715	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
662755003716	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
662755003717	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
662755003718	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
662755003719	FeS/SAM binding site; other site
662755003720	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
662755003721	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
662755003722	Walker A/P-loop; other site
662755003723	ATP binding site [chemical binding]; other site
662755003724	Q-loop/lid; other site
662755003725	ABC transporter signature motif; other site
662755003726	Walker B; other site
662755003727	D-loop; other site
662755003728	H-loop/switch region; other site
662755003729	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
662755003730	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
662755003731	substrate binding pocket [chemical binding]; other site
662755003732	membrane-bound complex binding site; other site
662755003733	hinge residues; other site
662755003734	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
662755003735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755003736	dimer interface [polypeptide binding]; other site
662755003737	conserved gate region; other site
662755003738	putative PBP binding loops; other site
662755003739	ABC-ATPase subunit interface; other site
662755003740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755003741	dimer interface [polypeptide binding]; other site
662755003742	conserved gate region; other site
662755003743	putative PBP binding loops; other site
662755003744	ABC-ATPase subunit interface; other site
662755003745	recombination regulator RecX; Reviewed; Region: recX; PRK00117
662755003746	recombinase A; Provisional; Region: recA; PRK09354
662755003747	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
662755003748	hexamer interface [polypeptide binding]; other site
662755003749	Walker A motif; other site
662755003750	ATP binding site [chemical binding]; other site
662755003751	Walker B motif; other site
662755003752	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
662755003753	BioY family; Region: BioY; pfam02632
662755003754	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755003755	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
662755003756	Walker A/P-loop; other site
662755003757	ATP binding site [chemical binding]; other site
662755003758	Q-loop/lid; other site
662755003759	ABC transporter signature motif; other site
662755003760	Walker B; other site
662755003761	D-loop; other site
662755003762	H-loop/switch region; other site
662755003763	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
662755003764	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
662755003765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755003766	non-specific DNA binding site [nucleotide binding]; other site
662755003767	salt bridge; other site
662755003768	sequence-specific DNA binding site [nucleotide binding]; other site
662755003769	Competence-damaged protein; Region: CinA; pfam02464
662755003770	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
662755003771	Integral membrane protein TerC family; Region: TerC; cl10468
662755003772	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
662755003773	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
662755003774	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
662755003775	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
662755003776	TIGR03085 family protein; Region: TIGR03085
662755003777	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
662755003778	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
662755003779	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
662755003780	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
662755003781	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
662755003782	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
662755003783	dimer interface [polypeptide binding]; other site
662755003784	active site
662755003785	catalytic residue [active]
662755003786	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
662755003787	dihydrodipicolinate reductase; Provisional; Region: PRK00048
662755003788	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
662755003789	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
662755003790	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
662755003791	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
662755003792	oligomer interface [polypeptide binding]; other site
662755003793	RNA binding site [nucleotide binding]; other site
662755003794	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
662755003795	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
662755003796	RNase E interface [polypeptide binding]; other site
662755003797	trimer interface [polypeptide binding]; other site
662755003798	active site
662755003799	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
662755003800	putative nucleic acid binding region [nucleotide binding]; other site
662755003801	G-X-X-G motif; other site
662755003802	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
662755003803	RNA binding site [nucleotide binding]; other site
662755003804	domain interface; other site
662755003805	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
662755003806	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
662755003807	catalytic residue [active]
662755003808	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
662755003809	16S/18S rRNA binding site [nucleotide binding]; other site
662755003810	S13e-L30e interaction site [polypeptide binding]; other site
662755003811	25S rRNA binding site [nucleotide binding]; other site
662755003812	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
662755003813	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
662755003814	active site
662755003815	Riboflavin kinase; Region: Flavokinase; smart00904
662755003816	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
662755003817	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
662755003818	RNA binding site [nucleotide binding]; other site
662755003819	active site
662755003820	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
662755003821	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
662755003822	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
662755003823	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
662755003824	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
662755003825	active site
662755003826	metal binding site [ion binding]; metal-binding site
662755003827	putative efflux protein, MATE family; Region: matE; TIGR00797
662755003828	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
662755003829	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
662755003830	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
662755003831	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
662755003832	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
662755003833	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
662755003834	G1 box; other site
662755003835	putative GEF interaction site [polypeptide binding]; other site
662755003836	GTP/Mg2+ binding site [chemical binding]; other site
662755003837	Switch I region; other site
662755003838	G2 box; other site
662755003839	G3 box; other site
662755003840	Switch II region; other site
662755003841	G4 box; other site
662755003842	G5 box; other site
662755003843	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
662755003844	Translation-initiation factor 2; Region: IF-2; pfam11987
662755003845	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
662755003846	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
662755003847	NusA N-terminal domain; Region: NusA_N; pfam08529
662755003848	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
662755003849	RNA binding site [nucleotide binding]; other site
662755003850	homodimer interface [polypeptide binding]; other site
662755003851	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
662755003852	G-X-X-G motif; other site
662755003853	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
662755003854	G-X-X-G motif; other site
662755003855	ribosome maturation protein RimP; Reviewed; Region: PRK00092
662755003856	Sm and related proteins; Region: Sm_like; cl00259
662755003857	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
662755003858	putative oligomer interface [polypeptide binding]; other site
662755003859	putative RNA binding site [nucleotide binding]; other site
662755003860	prolyl-tRNA synthetase; Provisional; Region: PRK09194
662755003861	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
662755003862	dimer interface [polypeptide binding]; other site
662755003863	motif 1; other site
662755003864	active site
662755003865	motif 2; other site
662755003866	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
662755003867	putative deacylase active site [active]
662755003868	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
662755003869	active site
662755003870	motif 3; other site
662755003871	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
662755003872	anticodon binding site; other site
662755003873	hypothetical protein; Validated; Region: PRK02101
662755003874	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
662755003875	active site
662755003876	SAM binding site [chemical binding]; other site
662755003877	homodimer interface [polypeptide binding]; other site
662755003878	malate:quinone oxidoreductase; Validated; Region: PRK05257
662755003879	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
662755003880	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
662755003881	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
662755003882	mycothione reductase; Reviewed; Region: PRK07846
662755003883	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755003884	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
662755003885	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
662755003886	short chain dehydrogenase; Provisional; Region: PRK07832
662755003887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755003888	NAD(P) binding site [chemical binding]; other site
662755003889	active site
662755003890	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
662755003891	Predicted membrane protein [General function prediction only]; Region: COG4194
662755003892	Predicted transcriptional regulators [Transcription]; Region: COG1725
662755003893	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
662755003894	DNA-binding site [nucleotide binding]; DNA binding site
662755003895	Uncharacterized conserved protein [Function unknown]; Region: COG2128
662755003896	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
662755003897	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
662755003898	active site
662755003899	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
662755003900	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
662755003901	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
662755003902	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755003903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755003904	active site
662755003905	phosphorylation site [posttranslational modification]
662755003906	intermolecular recognition site; other site
662755003907	dimerization interface [polypeptide binding]; other site
662755003908	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755003909	DNA binding residues [nucleotide binding]
662755003910	dimerization interface [polypeptide binding]; other site
662755003911	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
662755003912	Histidine kinase; Region: HisKA_3; pfam07730
662755003913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755003914	ATP binding site [chemical binding]; other site
662755003915	Mg2+ binding site [ion binding]; other site
662755003916	G-X-G motif; other site
662755003917	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
662755003918	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
662755003919	Walker A/P-loop; other site
662755003920	ATP binding site [chemical binding]; other site
662755003921	Q-loop/lid; other site
662755003922	ABC transporter signature motif; other site
662755003923	Walker B; other site
662755003924	D-loop; other site
662755003925	H-loop/switch region; other site
662755003926	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
662755003927	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
662755003928	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
662755003929	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
662755003930	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
662755003931	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
662755003932	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
662755003933	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
662755003934	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
662755003935	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
662755003936	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
662755003937	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
662755003938	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
662755003939	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
662755003940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
662755003941	FeS/SAM binding site; other site
662755003942	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
662755003943	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
662755003944	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
662755003945	ribosome recycling factor; Reviewed; Region: frr; PRK00083
662755003946	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
662755003947	hinge region; other site
662755003948	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
662755003949	putative nucleotide binding site [chemical binding]; other site
662755003950	uridine monophosphate binding site [chemical binding]; other site
662755003951	homohexameric interface [polypeptide binding]; other site
662755003952	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755003953	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755003954	Integrase core domain; Region: rve; pfam00665
662755003955	elongation factor Ts; Provisional; Region: tsf; PRK09377
662755003956	UBA/TS-N domain; Region: UBA; pfam00627
662755003957	Elongation factor TS; Region: EF_TS; pfam00889
662755003958	Elongation factor TS; Region: EF_TS; pfam00889
662755003959	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
662755003960	rRNA interaction site [nucleotide binding]; other site
662755003961	S8 interaction site; other site
662755003962	putative laminin-1 binding site; other site
662755003963	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
662755003964	Peptidase family M23; Region: Peptidase_M23; pfam01551
662755003965	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
662755003966	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
662755003967	active site
662755003968	DNA binding site [nucleotide binding]
662755003969	Int/Topo IB signature motif; other site
662755003970	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
662755003971	DNA protecting protein DprA; Region: dprA; TIGR00732
662755003972	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
662755003973	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
662755003974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755003975	Walker A motif; other site
662755003976	ATP binding site [chemical binding]; other site
662755003977	Walker B motif; other site
662755003978	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
662755003979	hypothetical protein; Reviewed; Region: PRK12497
662755003980	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
662755003981	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
662755003982	RNA/DNA hybrid binding site [nucleotide binding]; other site
662755003983	active site
662755003984	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
662755003985	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
662755003986	Catalytic site [active]
662755003987	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
662755003988	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
662755003989	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
662755003990	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
662755003991	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
662755003992	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
662755003993	RNA binding site [nucleotide binding]; other site
662755003994	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
662755003995	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
662755003996	NAD(P) binding site [chemical binding]; other site
662755003997	catalytic residues [active]
662755003998	BCCT family transporter; Region: BCCT; cl00569
662755003999	choline dehydrogenase; Validated; Region: PRK02106
662755004000	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
662755004001	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
662755004002	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
662755004003	RimM N-terminal domain; Region: RimM; pfam01782
662755004004	PRC-barrel domain; Region: PRC; pfam05239
662755004005	glutamate dehydrogenase; Provisional; Region: PRK09414
662755004006	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
662755004007	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
662755004008	NAD(P) binding site [chemical binding]; other site
662755004009	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
662755004010	Uncharacterized conserved protein [Function unknown]; Region: COG0397
662755004011	hypothetical protein; Validated; Region: PRK00029
662755004012	signal recognition particle protein; Provisional; Region: PRK10867
662755004013	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
662755004014	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
662755004015	P loop; other site
662755004016	GTP binding site [chemical binding]; other site
662755004017	Signal peptide binding domain; Region: SRP_SPB; pfam02978
662755004018	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
662755004019	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
662755004020	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
662755004021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
662755004022	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
662755004023	AAA domain; Region: AAA_23; pfam13476
662755004024	Walker A/P-loop; other site
662755004025	ATP binding site [chemical binding]; other site
662755004026	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
662755004027	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
662755004028	ABC transporter signature motif; other site
662755004029	Walker B; other site
662755004030	D-loop; other site
662755004031	H-loop/switch region; other site
662755004032	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
662755004033	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
662755004034	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
662755004035	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755004036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
662755004037	dimerization interface [polypeptide binding]; other site
662755004038	putative DNA binding site [nucleotide binding]; other site
662755004039	putative Zn2+ binding site [ion binding]; other site
662755004040	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
662755004041	arsenical-resistance protein; Region: acr3; TIGR00832
662755004042	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
662755004043	Low molecular weight phosphatase family; Region: LMWPc; cl00105
662755004044	active site
662755004045	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
662755004046	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
662755004047	DNA binding site [nucleotide binding]
662755004048	catalytic residue [active]
662755004049	H2TH interface [polypeptide binding]; other site
662755004050	putative catalytic residues [active]
662755004051	turnover-facilitating residue; other site
662755004052	intercalation triad [nucleotide binding]; other site
662755004053	8OG recognition residue [nucleotide binding]; other site
662755004054	putative reading head residues; other site
662755004055	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
662755004056	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
662755004057	ribonuclease III; Reviewed; Region: rnc; PRK00102
662755004058	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
662755004059	dimerization interface [polypeptide binding]; other site
662755004060	active site
662755004061	metal binding site [ion binding]; metal-binding site
662755004062	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
662755004063	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
662755004064	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
662755004065	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
662755004066	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
662755004067	active site
662755004068	(T/H)XGH motif; other site
662755004069	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
662755004070	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755004071	S-adenosylmethionine binding site [chemical binding]; other site
662755004072	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
662755004073	carboxyltransferase (CT) interaction site; other site
662755004074	biotinylation site [posttranslational modification]; other site
662755004075	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
662755004076	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
662755004077	generic binding surface II; other site
662755004078	ssDNA binding site; other site
662755004079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755004080	ATP binding site [chemical binding]; other site
662755004081	putative Mg++ binding site [ion binding]; other site
662755004082	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755004083	nucleotide binding region [chemical binding]; other site
662755004084	ATP-binding site [chemical binding]; other site
662755004085	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
662755004086	DAK2 domain; Region: Dak2; pfam02734
662755004087	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
662755004088	ligand binding site [chemical binding]; other site
662755004089	active site
662755004090	UGI interface [polypeptide binding]; other site
662755004091	catalytic site [active]
662755004092	thiamine monophosphate kinase; Provisional; Region: PRK05731
662755004093	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
662755004094	ATP binding site [chemical binding]; other site
662755004095	dimerization interface [polypeptide binding]; other site
662755004096	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
662755004097	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
662755004098	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
662755004099	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755004100	non-specific DNA binding site [nucleotide binding]; other site
662755004101	salt bridge; other site
662755004102	sequence-specific DNA binding site [nucleotide binding]; other site
662755004103	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
662755004104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004105	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
662755004106	Cytochrome P450; Region: p450; cl12078
662755004107	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
662755004108	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
662755004109	ATP-grasp domain; Region: ATP-grasp_4; cl17255
662755004110	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
662755004111	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
662755004112	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
662755004113	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
662755004114	active site
662755004115	Ap6A binding site [chemical binding]; other site
662755004116	nudix motif; other site
662755004117	metal binding site [ion binding]; metal-binding site
662755004118	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755004119	catalytic core [active]
662755004120	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
662755004121	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
662755004122	substrate binding site [chemical binding]; other site
662755004123	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
662755004124	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
662755004125	substrate binding site [chemical binding]; other site
662755004126	ligand binding site [chemical binding]; other site
662755004127	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
662755004128	Transcriptional regulator [Transcription]; Region: IclR; COG1414
662755004129	Bacterial transcriptional regulator; Region: IclR; pfam01614
662755004130	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
662755004131	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
662755004132	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
662755004133	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
662755004134	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
662755004135	DNA binding residues [nucleotide binding]
662755004136	dimer interface [polypeptide binding]; other site
662755004137	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
662755004138	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
662755004139	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
662755004140	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
662755004141	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
662755004142	Soluble P-type ATPase [General function prediction only]; Region: COG4087
662755004143	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
662755004144	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
662755004145	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
662755004146	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
662755004147	Ligand Binding Site [chemical binding]; other site
662755004148	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
662755004149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
662755004150	dimer interface [polypeptide binding]; other site
662755004151	phosphorylation site [posttranslational modification]
662755004152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755004153	ATP binding site [chemical binding]; other site
662755004154	Mg2+ binding site [ion binding]; other site
662755004155	G-X-G motif; other site
662755004156	Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887
662755004157	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
662755004158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755004159	active site
662755004160	phosphorylation site [posttranslational modification]
662755004161	intermolecular recognition site; other site
662755004162	dimerization interface [polypeptide binding]; other site
662755004163	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
662755004164	DNA binding site [nucleotide binding]
662755004165	Predicted membrane protein [Function unknown]; Region: COG1297
662755004166	putative oligopeptide transporter, OPT family; Region: TIGR00733
662755004167	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
662755004168	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
662755004169	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
662755004170	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
662755004171	GIY-YIG motif/motif A; other site
662755004172	active site
662755004173	catalytic site [active]
662755004174	AAA ATPase domain; Region: AAA_16; pfam13191
662755004175	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
662755004176	Uncharacterized conserved protein [Function unknown]; Region: COG3410
662755004177	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
662755004178	FIC domain binding interface [polypeptide binding]; other site
662755004179	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
662755004180	DoxX-like family; Region: DoxX_2; pfam13564
662755004181	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
662755004182	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
662755004183	FAD binding pocket [chemical binding]; other site
662755004184	FAD binding motif [chemical binding]; other site
662755004185	phosphate binding motif [ion binding]; other site
662755004186	beta-alpha-beta structure motif; other site
662755004187	NAD binding pocket [chemical binding]; other site
662755004188	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
662755004189	catalytic loop [active]
662755004190	iron binding site [ion binding]; other site
662755004191	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
662755004192	putative di-iron ligands [ion binding]; other site
662755004193	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
662755004194	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
662755004195	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
662755004196	active site
662755004197	HIGH motif; other site
662755004198	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
662755004199	active site
662755004200	KMSKS motif; other site
662755004201	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
662755004202	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
662755004203	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
662755004204	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
662755004205	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
662755004206	putative transposase OrfB; Reviewed; Region: PHA02517
662755004207	HTH-like domain; Region: HTH_21; pfam13276
662755004208	Integrase core domain; Region: rve; pfam00665
662755004209	Integrase core domain; Region: rve_2; pfam13333
662755004210	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
662755004211	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755004212	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
662755004213	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
662755004214	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755004215	ABC transporter signature motif; other site
662755004216	Walker B; other site
662755004217	D-loop; other site
662755004218	H-loop/switch region; other site
662755004219	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755004220	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
662755004221	Walker A/P-loop; other site
662755004222	ATP binding site [chemical binding]; other site
662755004223	Q-loop/lid; other site
662755004224	ABC transporter signature motif; other site
662755004225	Walker B; other site
662755004226	D-loop; other site
662755004227	H-loop/switch region; other site
662755004228	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
662755004229	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755004230	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755004231	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004232	Walker A/P-loop; other site
662755004233	ATP binding site [chemical binding]; other site
662755004234	Q-loop/lid; other site
662755004235	ABC transporter signature motif; other site
662755004236	Walker B; other site
662755004237	D-loop; other site
662755004238	H-loop/switch region; other site
662755004239	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755004240	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755004241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004242	Walker A/P-loop; other site
662755004243	ATP binding site [chemical binding]; other site
662755004244	Q-loop/lid; other site
662755004245	ABC transporter signature motif; other site
662755004246	Walker B; other site
662755004247	D-loop; other site
662755004248	H-loop/switch region; other site
662755004249	Transposase, Mutator family; Region: Transposase_mut; pfam00872
662755004250	MULE transposase domain; Region: MULE; pfam10551
662755004251	Homeodomain-like domain; Region: HTH_23; pfam13384
662755004252	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755004253	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755004254	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755004255	Integrase core domain; Region: rve; pfam00665
662755004256	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
662755004257	classical (c) SDRs; Region: SDR_c; cd05233
662755004258	NAD(P) binding site [chemical binding]; other site
662755004259	active site
662755004260	isochorismate synthase DhbC; Validated; Region: PRK06923
662755004261	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
662755004262	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
662755004263	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
662755004264	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
662755004265	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
662755004266	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
662755004267	active site
662755004268	catalytic site [active]
662755004269	substrate binding site [chemical binding]; other site
662755004270	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
662755004271	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
662755004272	ligand binding site [chemical binding]; other site
662755004273	flexible hinge region; other site
662755004274	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
662755004275	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
662755004276	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
662755004277	metal binding triad; other site
662755004278	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
662755004279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
662755004280	Integrase core domain; Region: rve; pfam00665
662755004281	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
662755004282	tartrate dehydrogenase; Region: TTC; TIGR02089
662755004283	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
662755004284	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
662755004285	Walker A/P-loop; other site
662755004286	ATP binding site [chemical binding]; other site
662755004287	Q-loop/lid; other site
662755004288	ABC transporter signature motif; other site
662755004289	Walker B; other site
662755004290	D-loop; other site
662755004291	H-loop/switch region; other site
662755004292	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
662755004293	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
662755004294	ligand binding site [chemical binding]; other site
662755004295	NAD binding site [chemical binding]; other site
662755004296	dimerization interface [polypeptide binding]; other site
662755004297	catalytic site [active]
662755004298	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
662755004299	putative L-serine binding site [chemical binding]; other site
662755004300	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
662755004301	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
662755004302	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
662755004303	proline/glycine betaine transporter; Provisional; Region: PRK10642
662755004304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004305	putative substrate translocation pore; other site
662755004306	ketol-acid reductoisomerase; Provisional; Region: PRK05479
662755004307	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
662755004308	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
662755004309	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
662755004310	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
662755004311	putative valine binding site [chemical binding]; other site
662755004312	dimer interface [polypeptide binding]; other site
662755004313	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
662755004314	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
662755004315	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
662755004316	PYR/PP interface [polypeptide binding]; other site
662755004317	dimer interface [polypeptide binding]; other site
662755004318	TPP binding site [chemical binding]; other site
662755004319	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
662755004320	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
662755004321	TPP-binding site [chemical binding]; other site
662755004322	dimer interface [polypeptide binding]; other site
662755004323	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
662755004324	Mechanosensitive ion channel; Region: MS_channel; pfam00924
662755004325	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
662755004326	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
662755004327	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
662755004328	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
662755004329	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
662755004330	putative dimer interface [polypeptide binding]; other site
662755004331	N-terminal domain interface [polypeptide binding]; other site
662755004332	putative substrate binding pocket (H-site) [chemical binding]; other site
662755004333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
662755004334	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
662755004335	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
662755004336	dimerization interface [polypeptide binding]; other site
662755004337	LysE type translocator; Region: LysE; cl00565
662755004338	LysE type translocator; Region: LysE; cl00565
662755004339	Predicted membrane protein [Function unknown]; Region: COG2259
662755004340	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
662755004341	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
662755004342	GatB domain; Region: GatB_Yqey; smart00845
662755004343	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
662755004344	6-phosphofructokinase; Provisional; Region: PRK03202
662755004345	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
662755004346	active site
662755004347	ADP/pyrophosphate binding site [chemical binding]; other site
662755004348	dimerization interface [polypeptide binding]; other site
662755004349	allosteric effector site; other site
662755004350	fructose-1,6-bisphosphate binding site; other site
662755004351	putative transporter; Provisional; Region: PRK10504
662755004352	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004353	putative substrate translocation pore; other site
662755004354	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
662755004355	nudix motif; other site
662755004356	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
662755004357	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
662755004358	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
662755004359	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
662755004360	threonine dehydratase; Reviewed; Region: PRK09224
662755004361	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
662755004362	tetramer interface [polypeptide binding]; other site
662755004363	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755004364	catalytic residue [active]
662755004365	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
662755004366	putative Ile/Val binding site [chemical binding]; other site
662755004367	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
662755004368	putative Ile/Val binding site [chemical binding]; other site
662755004369	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
662755004370	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
662755004371	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
662755004372	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
662755004373	active site
662755004374	catalytic site [active]
662755004375	substrate binding site [chemical binding]; other site
662755004376	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
662755004377	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
662755004378	Walker A/P-loop; other site
662755004379	ATP binding site [chemical binding]; other site
662755004380	Q-loop/lid; other site
662755004381	ABC transporter signature motif; other site
662755004382	Walker B; other site
662755004383	D-loop; other site
662755004384	H-loop/switch region; other site
662755004385	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
662755004386	Histidine kinase; Region: HisKA_3; pfam07730
662755004387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755004388	ATP binding site [chemical binding]; other site
662755004389	Mg2+ binding site [ion binding]; other site
662755004390	G-X-G motif; other site
662755004391	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755004392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755004393	active site
662755004394	phosphorylation site [posttranslational modification]
662755004395	intermolecular recognition site; other site
662755004396	dimerization interface [polypeptide binding]; other site
662755004397	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755004398	DNA binding residues [nucleotide binding]
662755004399	dimerization interface [polypeptide binding]; other site
662755004400	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
662755004401	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
662755004402	nucleotide binding pocket [chemical binding]; other site
662755004403	K-X-D-G motif; other site
662755004404	catalytic site [active]
662755004405	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
662755004406	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
662755004407	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
662755004408	Dimer interface [polypeptide binding]; other site
662755004409	BRCT sequence motif; other site
662755004410	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
662755004411	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
662755004412	Ligand Binding Site [chemical binding]; other site
662755004413	Protein of unknown function, DUF393; Region: DUF393; pfam04134
662755004414	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
662755004415	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
662755004416	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
662755004417	catalytic residue [active]
662755004418	AAA ATPase domain; Region: AAA_16; pfam13191
662755004419	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
662755004420	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
662755004421	Ligand Binding Site [chemical binding]; other site
662755004422	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
662755004423	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
662755004424	Ligand binding site [chemical binding]; other site
662755004425	Electron transfer flavoprotein domain; Region: ETF; pfam01012
662755004426	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
662755004427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004428	Walker A/P-loop; other site
662755004429	ATP binding site [chemical binding]; other site
662755004430	Q-loop/lid; other site
662755004431	ABC transporter signature motif; other site
662755004432	Walker B; other site
662755004433	D-loop; other site
662755004434	H-loop/switch region; other site
662755004435	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
662755004436	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
662755004437	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
662755004438	active site
662755004439	homodimer interface [polypeptide binding]; other site
662755004440	catalytic site [active]
662755004441	acceptor binding site [chemical binding]; other site
662755004442	glycogen branching enzyme; Provisional; Region: PRK05402
662755004443	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
662755004444	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
662755004445	active site
662755004446	catalytic site [active]
662755004447	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
662755004448	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
662755004449	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
662755004450	hypothetical protein; Provisional; Region: PRK03298
662755004451	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
662755004452	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
662755004453	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
662755004454	gamma subunit interface [polypeptide binding]; other site
662755004455	epsilon subunit interface [polypeptide binding]; other site
662755004456	LBP interface [polypeptide binding]; other site
662755004457	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
662755004458	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
662755004459	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
662755004460	alpha subunit interaction interface [polypeptide binding]; other site
662755004461	Walker A motif; other site
662755004462	ATP binding site [chemical binding]; other site
662755004463	Walker B motif; other site
662755004464	inhibitor binding site; inhibition site
662755004465	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
662755004466	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
662755004467	core domain interface [polypeptide binding]; other site
662755004468	delta subunit interface [polypeptide binding]; other site
662755004469	epsilon subunit interface [polypeptide binding]; other site
662755004470	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
662755004471	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
662755004472	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
662755004473	beta subunit interaction interface [polypeptide binding]; other site
662755004474	Walker A motif; other site
662755004475	ATP binding site [chemical binding]; other site
662755004476	Walker B motif; other site
662755004477	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
662755004478	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
662755004479	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
662755004480	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
662755004481	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
662755004482	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
662755004483	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
662755004484	Predicted membrane protein [Function unknown]; Region: COG2323
662755004485	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
662755004486	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
662755004487	Mg++ binding site [ion binding]; other site
662755004488	putative catalytic motif [active]
662755004489	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
662755004490	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
662755004491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755004492	S-adenosylmethionine binding site [chemical binding]; other site
662755004493	peptide chain release factor 1; Validated; Region: prfA; PRK00591
662755004494	PCRF domain; Region: PCRF; pfam03462
662755004495	RF-1 domain; Region: RF-1; pfam00472
662755004496	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
662755004497	transcription termination factor Rho; Provisional; Region: PRK12608
662755004498	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
662755004499	RNA binding site [nucleotide binding]; other site
662755004500	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
662755004501	multimer interface [polypeptide binding]; other site
662755004502	Walker A motif; other site
662755004503	ATP binding site [chemical binding]; other site
662755004504	Walker B motif; other site
662755004505	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
662755004506	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755004507	acyl-activating enzyme (AAE) consensus motif; other site
662755004508	AMP binding site [chemical binding]; other site
662755004509	active site
662755004510	CoA binding site [chemical binding]; other site
662755004511	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
662755004512	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
662755004513	homoserine kinase; Provisional; Region: PRK01212
662755004514	homoserine dehydrogenase; Provisional; Region: PRK06349
662755004515	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
662755004516	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
662755004517	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
662755004518	diaminopimelate decarboxylase; Region: lysA; TIGR01048
662755004519	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
662755004520	active site
662755004521	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
662755004522	substrate binding site [chemical binding]; other site
662755004523	catalytic residues [active]
662755004524	dimer interface [polypeptide binding]; other site
662755004525	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
662755004526	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
662755004527	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
662755004528	active site
662755004529	HIGH motif; other site
662755004530	KMSK motif region; other site
662755004531	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
662755004532	tRNA binding surface [nucleotide binding]; other site
662755004533	anticodon binding site; other site
662755004534	AAA domain; Region: AAA_23; pfam13476
662755004535	P-loop containing region of AAA domain; Region: AAA_29; cl17516
662755004536	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
662755004537	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
662755004538	active site
662755004539	metal binding site [ion binding]; metal-binding site
662755004540	DNA binding site [nucleotide binding]
662755004541	Uncharacterized conserved protein [Function unknown]; Region: COG4279
662755004542	SNF2 Helicase protein; Region: DUF3670; pfam12419
662755004543	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
662755004544	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755004545	ATP binding site [chemical binding]; other site
662755004546	putative Mg++ binding site [ion binding]; other site
662755004547	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755004548	nucleotide binding region [chemical binding]; other site
662755004549	ATP-binding site [chemical binding]; other site
662755004550	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
662755004551	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
662755004552	Na binding site [ion binding]; other site
662755004553	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
662755004554	helicase 45; Provisional; Region: PTZ00424
662755004555	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
662755004556	ATP binding site [chemical binding]; other site
662755004557	Mg++ binding site [ion binding]; other site
662755004558	motif III; other site
662755004559	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755004560	nucleotide binding region [chemical binding]; other site
662755004561	ATP-binding site [chemical binding]; other site
662755004562	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
662755004563	putative RNA binding site [nucleotide binding]; other site
662755004564	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
662755004565	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
662755004566	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
662755004567	substrate binding pocket [chemical binding]; other site
662755004568	catalytic triad [active]
662755004569	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
662755004570	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
662755004571	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
662755004572	TPP-binding site [chemical binding]; other site
662755004573	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
662755004574	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
662755004575	Domain of unknown function DUF59; Region: DUF59; pfam01883
662755004576	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
662755004577	sec-independent translocase; Provisional; Region: tatB; PRK00182
662755004578	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
662755004579	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
662755004580	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755004581	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755004582	DNA binding residues [nucleotide binding]
662755004583	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
662755004584	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
662755004585	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
662755004586	ligand binding site; other site
662755004587	oligomer interface; other site
662755004588	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
662755004589	dimer interface [polypeptide binding]; other site
662755004590	N-terminal domain interface [polypeptide binding]; other site
662755004591	sulfate 1 binding site; other site
662755004592	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
662755004593	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
662755004594	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
662755004595	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
662755004596	active site
662755004597	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
662755004598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755004599	S-adenosylmethionine binding site [chemical binding]; other site
662755004600	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
662755004601	multifunctional aminopeptidase A; Provisional; Region: PRK00913
662755004602	interface (dimer of trimers) [polypeptide binding]; other site
662755004603	Substrate-binding/catalytic site; other site
662755004604	Zn-binding sites [ion binding]; other site
662755004605	DivIVA domain; Region: DivI1A_domain; TIGR03544
662755004606	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
662755004607	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
662755004608	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
662755004609	metal binding site [ion binding]; metal-binding site
662755004610	putative dimer interface [polypeptide binding]; other site
662755004611	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
662755004612	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
662755004613	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
662755004614	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
662755004615	putative trimer interface [polypeptide binding]; other site
662755004616	putative CoA binding site [chemical binding]; other site
662755004617	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
662755004618	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
662755004619	active site
662755004620	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
662755004621	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755004622	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755004623	homodimer interface [polypeptide binding]; other site
662755004624	catalytic residue [active]
662755004625	Ferredoxin [Energy production and conversion]; Region: COG1146
662755004626	4Fe-4S binding domain; Region: Fer4; pfam00037
662755004627	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
662755004628	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
662755004629	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
662755004630	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
662755004631	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
662755004632	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
662755004633	G1 box; other site
662755004634	putative GEF interaction site [polypeptide binding]; other site
662755004635	GTP/Mg2+ binding site [chemical binding]; other site
662755004636	Switch I region; other site
662755004637	G2 box; other site
662755004638	G3 box; other site
662755004639	Switch II region; other site
662755004640	G4 box; other site
662755004641	G5 box; other site
662755004642	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
662755004643	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
662755004644	Uncharacterized protein family (UPF0253); Region: UPF0253; cl11640
662755004645	Protein of unknown function (DUF402); Region: DUF402; cl00979
662755004646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755004647	NADH(P)-binding; Region: NAD_binding_10; pfam13460
662755004648	NAD(P) binding site [chemical binding]; other site
662755004649	active site
662755004650	Excalibur calcium-binding domain; Region: Excalibur; smart00894
662755004651	HTH-like domain; Region: HTH_21; pfam13276
662755004652	Integrase core domain; Region: rve; pfam00665
662755004653	Integrase core domain; Region: rve_2; pfam13333
662755004654	Helix-turn-helix domain; Region: HTH_28; pfam13518
662755004655	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755004656	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755004657	active site
662755004658	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
662755004659	Cutinase; Region: Cutinase; pfam01083
662755004660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
662755004661	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
662755004662	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
662755004663	active site
662755004664	nucleophile elbow; other site
662755004665	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
662755004666	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
662755004667	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
662755004668	Methyltransferase domain; Region: Methyltransf_23; pfam13489
662755004669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755004670	S-adenosylmethionine binding site [chemical binding]; other site
662755004671	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
662755004672	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755004673	Walker A/P-loop; other site
662755004674	ATP binding site [chemical binding]; other site
662755004675	Q-loop/lid; other site
662755004676	ABC transporter signature motif; other site
662755004677	Walker B; other site
662755004678	D-loop; other site
662755004679	H-loop/switch region; other site
662755004680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004681	Walker A/P-loop; other site
662755004682	ATP binding site [chemical binding]; other site
662755004683	Q-loop/lid; other site
662755004684	ABC transporter signature motif; other site
662755004685	Walker B; other site
662755004686	D-loop; other site
662755004687	H-loop/switch region; other site
662755004688	Cobalt transport protein; Region: CbiQ; cl00463
662755004689	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
662755004690	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755004691	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755004692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004693	Walker A/P-loop; other site
662755004694	ATP binding site [chemical binding]; other site
662755004695	Q-loop/lid; other site
662755004696	ABC transporter signature motif; other site
662755004697	Walker B; other site
662755004698	D-loop; other site
662755004699	H-loop/switch region; other site
662755004700	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
662755004701	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755004702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004703	Walker A/P-loop; other site
662755004704	ATP binding site [chemical binding]; other site
662755004705	Q-loop/lid; other site
662755004706	ABC transporter signature motif; other site
662755004707	Walker B; other site
662755004708	D-loop; other site
662755004709	H-loop/switch region; other site
662755004710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004711	Major Facilitator Superfamily; Region: MFS_1; pfam07690
662755004712	putative substrate translocation pore; other site
662755004713	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755004714	S-adenosylmethionine binding site [chemical binding]; other site
662755004715	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
662755004716	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755004717	sequence-specific DNA binding site [nucleotide binding]; other site
662755004718	salt bridge; other site
662755004719	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
662755004720	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
662755004721	dimerization interface [polypeptide binding]; other site
662755004722	putative DNA binding site [nucleotide binding]; other site
662755004723	putative Zn2+ binding site [ion binding]; other site
662755004724	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
662755004725	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
662755004726	Soluble P-type ATPase [General function prediction only]; Region: COG4087
662755004727	Protein of unknown function DUF2625; Region: DUF2625; cl08177
662755004728	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
662755004729	hypothetical protein; Provisional; Region: PRK09256
662755004730	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
662755004731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755004732	salt bridge; other site
662755004733	non-specific DNA binding site [nucleotide binding]; other site
662755004734	sequence-specific DNA binding site [nucleotide binding]; other site
662755004735	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
662755004736	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
662755004737	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
662755004738	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755004739	ATP binding site [chemical binding]; other site
662755004740	putative Mg++ binding site [ion binding]; other site
662755004741	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
662755004742	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
662755004743	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
662755004744	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
662755004745	Integrase core domain; Region: rve; pfam00665
662755004746	Integrase core domain; Region: rve_3; pfam13683
662755004747	Transposase; Region: HTH_Tnp_1; cl17663
662755004748	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
662755004749	ABC-ATPase subunit  interface; other site
662755004750	dimer interface [polypeptide binding]; other site
662755004751	putative PBP binding regions; other site
662755004752	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755004753	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755004754	ABC-ATPase subunit  interface; other site
662755004755	dimer interface [polypeptide binding]; other site
662755004756	putative PBP binding regions; other site
662755004757	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
662755004758	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755004759	intersubunit interface [polypeptide binding]; other site
662755004760	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
662755004761	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755004762	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755004763	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
662755004764	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
662755004765	Walker A/P-loop; other site
662755004766	ATP binding site [chemical binding]; other site
662755004767	Q-loop/lid; other site
662755004768	ABC transporter signature motif; other site
662755004769	Walker B; other site
662755004770	D-loop; other site
662755004771	H-loop/switch region; other site
662755004772	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755004773	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
662755004774	Walker A/P-loop; other site
662755004775	ATP binding site [chemical binding]; other site
662755004776	Q-loop/lid; other site
662755004777	ABC transporter signature motif; other site
662755004778	Walker B; other site
662755004779	D-loop; other site
662755004780	H-loop/switch region; other site
662755004781	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
662755004782	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
662755004783	FAD binding pocket [chemical binding]; other site
662755004784	FAD binding motif [chemical binding]; other site
662755004785	phosphate binding motif [ion binding]; other site
662755004786	NAD binding pocket [chemical binding]; other site
662755004787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004788	putative substrate translocation pore; other site
662755004789	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
662755004790	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
662755004791	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
662755004792	DNA binding residues [nucleotide binding]
662755004793	dimer interface [polypeptide binding]; other site
662755004794	[2Fe-2S] cluster binding site [ion binding]; other site
662755004795	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
662755004796	HsdM N-terminal domain; Region: HsdM_N; pfam12161
662755004797	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
662755004798	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
662755004799	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
662755004800	DNA binding residues [nucleotide binding]
662755004801	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
662755004802	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
662755004803	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
662755004804	active site
662755004805	DNA binding site [nucleotide binding]
662755004806	catalytic site [active]
662755004807	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
662755004808	Prophage antirepressor [Transcription]; Region: COG3617
662755004809	BRO family, N-terminal domain; Region: Bro-N; smart01040
662755004810	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
662755004811	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
662755004812	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
662755004813	D5 N terminal like; Region: D5_N; pfam08706
662755004814	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
662755004815	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
662755004816	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755004817	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
662755004818	ATP binding site [chemical binding]; other site
662755004819	putative Mg++ binding site [ion binding]; other site
662755004820	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
662755004821	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
662755004822	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
662755004823	Phage terminase, small subunit; Region: Terminase_4; cl01525
662755004824	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
662755004825	S-adenosylmethionine synthetase; Provisional; Region: PRK12459
662755004826	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
662755004827	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
662755004828	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
662755004829	ParB-like nuclease domain; Region: ParBc; pfam02195
662755004830	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
662755004831	DNA methylase; Region: N6_N4_Mtase; pfam01555
662755004832	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
662755004833	Phage-related protein [Function unknown]; Region: COG4695
662755004834	Phage portal protein; Region: Phage_portal; pfam04860
662755004835	Clp protease; Region: CLP_protease; pfam00574
662755004836	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
662755004837	oligomer interface [polypeptide binding]; other site
662755004838	active site residues [active]
662755004839	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
662755004840	Phage capsid family; Region: Phage_capsid; pfam05065
662755004841	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
662755004842	oligomerization interface [polypeptide binding]; other site
662755004843	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
662755004844	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
662755004845	Phage-related protein [Function unknown]; Region: COG5412
662755004846	tape measure domain; Region: tape_meas_nterm; TIGR02675
662755004847	Phage-related protein [Function unknown]; Region: COG4722
662755004848	Phage tail protein; Region: Sipho_tail; cl17486
662755004849	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
662755004850	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
662755004851	Holin family; Region: Phage_holin_4; pfam05105
662755004852	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
662755004853	amidase catalytic site [active]
662755004854	Zn binding residues [ion binding]; other site
662755004855	substrate binding site [chemical binding]; other site
662755004856	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
662755004857	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
662755004858	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
662755004859	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
662755004860	catalytic residues [active]
662755004861	catalytic nucleophile [active]
662755004862	Recombinase; Region: Recombinase; pfam07508
662755004863	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
662755004864	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
662755004865	catalytic residues [active]
662755004866	catalytic nucleophile [active]
662755004867	Recombinase; Region: Recombinase; pfam07508
662755004868	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
662755004869	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
662755004870	HsdM N-terminal domain; Region: HsdM_N; pfam12161
662755004871	GTP-binding protein YchF; Reviewed; Region: PRK09601
662755004872	YchF GTPase; Region: YchF; cd01900
662755004873	G1 box; other site
662755004874	GTP/Mg2+ binding site [chemical binding]; other site
662755004875	Switch I region; other site
662755004876	G2 box; other site
662755004877	Switch II region; other site
662755004878	G3 box; other site
662755004879	G4 box; other site
662755004880	G5 box; other site
662755004881	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
662755004882	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
662755004883	Na2 binding site [ion binding]; other site
662755004884	putative substrate binding site 1 [chemical binding]; other site
662755004885	Na binding site 1 [ion binding]; other site
662755004886	putative substrate binding site 2 [chemical binding]; other site
662755004887	Domain of unknown function DUF20; Region: UPF0118; pfam01594
662755004888	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
662755004889	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
662755004890	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
662755004891	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
662755004892	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
662755004893	generic binding surface II; other site
662755004894	generic binding surface I; other site
662755004895	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
662755004896	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
662755004897	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
662755004898	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
662755004899	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
662755004900	putative active site [active]
662755004901	fumarate hydratase; Reviewed; Region: fumC; PRK00485
662755004902	Class II fumarases; Region: Fumarase_classII; cd01362
662755004903	active site
662755004904	tetramer interface [polypeptide binding]; other site
662755004905	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
662755004906	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755004907	Major Facilitator Superfamily; Region: MFS_1; pfam07690
662755004908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755004910	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
662755004911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755004912	Coenzyme A binding pocket [chemical binding]; other site
662755004913	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
662755004914	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
662755004915	putative active site [active]
662755004916	PhoH-like protein; Region: PhoH; pfam02562
662755004917	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
662755004918	Transcriptional regulator [Transcription]; Region: LysR; COG0583
662755004919	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
662755004920	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755004921	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755004922	active site
662755004923	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
662755004924	putative homodimer interface [polypeptide binding]; other site
662755004925	putative homotetramer interface [polypeptide binding]; other site
662755004926	putative allosteric switch controlling residues; other site
662755004927	putative metal binding site [ion binding]; other site
662755004928	putative homodimer-homodimer interface [polypeptide binding]; other site
662755004929	Predicted permeases [General function prediction only]; Region: COG0730
662755004930	enoyl-CoA hydratase; Provisional; Region: PRK06688
662755004931	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755004932	substrate binding site [chemical binding]; other site
662755004933	oxyanion hole (OAH) forming residues; other site
662755004934	trimer interface [polypeptide binding]; other site
662755004935	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
662755004936	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
662755004937	dimer interface [polypeptide binding]; other site
662755004938	active site
662755004939	glycine-pyridoxal phosphate binding site [chemical binding]; other site
662755004940	folate binding site [chemical binding]; other site
662755004941	pantothenate kinase; Provisional; Region: PRK05439
662755004942	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
662755004943	ATP-binding site [chemical binding]; other site
662755004944	CoA-binding site [chemical binding]; other site
662755004945	Mg2+-binding site [ion binding]; other site
662755004946	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
662755004947	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
662755004948	catalytic residue [active]
662755004949	putative FPP diphosphate  binding site; other site
662755004950	putative FPP binding hydrophobic cleft; other site
662755004951	dimer interface [polypeptide binding]; other site
662755004952	putative IPP diphosphate binding site; other site
662755004953	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
662755004954	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
662755004955	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
662755004956	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
662755004957	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
662755004958	Bax inhibitor 1 like; Region: BaxI_1; cl17691
662755004959	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
662755004960	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
662755004961	NAD(P) binding site [chemical binding]; other site
662755004962	catalytic residues [active]
662755004963	short chain dehydrogenase; Provisional; Region: PRK08219
662755004964	classical (c) SDRs; Region: SDR_c; cd05233
662755004965	NAD(P) binding site [chemical binding]; other site
662755004966	active site
662755004967	Uncharacterized conserved protein [Function unknown]; Region: COG0062
662755004968	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
662755004969	putative substrate binding site [chemical binding]; other site
662755004970	putative ATP binding site [chemical binding]; other site
662755004971	Uncharacterized conserved protein [Function unknown]; Region: COG1507
662755004972	exopolyphosphatase; Region: exo_poly_only; TIGR03706
662755004973	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
662755004974	Septum formation initiator; Region: DivIC; pfam04977
662755004975	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
662755004976	enolase; Provisional; Region: eno; PRK00077
662755004977	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
662755004978	dimer interface [polypeptide binding]; other site
662755004979	metal binding site [ion binding]; metal-binding site
662755004980	substrate binding pocket [chemical binding]; other site
662755004981	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
662755004982	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
662755004983	N-acetyl-D-glucosamine binding site [chemical binding]; other site
662755004984	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
662755004985	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
662755004986	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
662755004987	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
662755004988	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
662755004989	metal binding site [ion binding]; metal-binding site
662755004990	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
662755004991	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
662755004992	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
662755004993	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755004994	ABC-ATPase subunit  interface; other site
662755004995	dimer interface [polypeptide binding]; other site
662755004996	putative PBP binding regions; other site
662755004997	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
662755004998	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
662755004999	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
662755005000	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755005001	ATP binding site [chemical binding]; other site
662755005002	putative Mg++ binding site [ion binding]; other site
662755005003	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755005004	nucleotide binding region [chemical binding]; other site
662755005005	ATP-binding site [chemical binding]; other site
662755005006	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
662755005007	MULE transposase domain; Region: MULE; pfam10551
662755005008	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
662755005009	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
662755005010	Substrate binding site; other site
662755005011	Mg++ binding site; other site
662755005012	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
662755005013	active site
662755005014	substrate binding site [chemical binding]; other site
662755005015	CoA binding site [chemical binding]; other site
662755005016	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
662755005017	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
662755005018	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755005019	active site
662755005020	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
662755005021	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
662755005022	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
662755005023	5S rRNA interface [nucleotide binding]; other site
662755005024	CTC domain interface [polypeptide binding]; other site
662755005025	L16 interface [polypeptide binding]; other site
662755005026	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
662755005027	putative active site [active]
662755005028	catalytic residue [active]
662755005029	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
662755005030	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
662755005031	G1 box; other site
662755005032	putative GEF interaction site [polypeptide binding]; other site
662755005033	GTP/Mg2+ binding site [chemical binding]; other site
662755005034	Switch I region; other site
662755005035	G2 box; other site
662755005036	G3 box; other site
662755005037	Switch II region; other site
662755005038	G4 box; other site
662755005039	G5 box; other site
662755005040	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
662755005041	hydroperoxidase II; Provisional; Region: katE; PRK11249
662755005042	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
662755005043	heme binding pocket [chemical binding]; other site
662755005044	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
662755005045	domain interactions; other site
662755005046	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
662755005047	putative active site [active]
662755005048	catalytic residue [active]
662755005049	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
662755005050	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
662755005051	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
662755005052	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755005053	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
662755005054	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
662755005055	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755005056	substrate binding site [chemical binding]; other site
662755005057	oxyanion hole (OAH) forming residues; other site
662755005058	trimer interface [polypeptide binding]; other site
662755005059	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
662755005060	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
662755005061	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
662755005062	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
662755005063	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
662755005064	Uncharacterized conserved protein [Function unknown]; Region: COG1359
662755005065	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
662755005066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755005067	Walker A/P-loop; other site
662755005068	ATP binding site [chemical binding]; other site
662755005069	Q-loop/lid; other site
662755005070	ABC transporter signature motif; other site
662755005071	Walker B; other site
662755005072	D-loop; other site
662755005073	H-loop/switch region; other site
662755005074	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755005075	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
662755005076	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
662755005077	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
662755005078	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
662755005079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
662755005080	Domain of unknown function (DUF348); Region: DUF348; pfam03990
662755005081	Domain of unknown function (DUF348); Region: DUF348; pfam03990
662755005082	Domain of unknown function (DUF348); Region: DUF348; pfam03990
662755005083	G5 domain; Region: G5; pfam07501
662755005084	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
662755005085	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
662755005086	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
662755005087	active site
662755005088	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
662755005089	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
662755005090	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
662755005091	active site
662755005092	HIGH motif; other site
662755005093	KMSKS motif; other site
662755005094	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
662755005095	tRNA binding surface [nucleotide binding]; other site
662755005096	anticodon binding site; other site
662755005097	Predicted transcriptional regulator [Transcription]; Region: COG1959
662755005098	Transcriptional regulator; Region: Rrf2; cl17282
662755005099	BCCT family transporter; Region: BCCT; pfam02028
662755005100	Predicted methyltransferases [General function prediction only]; Region: COG0313
662755005101	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
662755005102	putative SAM binding site [chemical binding]; other site
662755005103	putative homodimer interface [polypeptide binding]; other site
662755005104	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
662755005105	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
662755005106	Predicted integral membrane protein [Function unknown]; Region: COG5660
662755005107	Putative zinc-finger; Region: zf-HC2; pfam13490
662755005108	Predicted membrane protein [Function unknown]; Region: COG2259
662755005109	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
662755005110	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
662755005111	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
662755005112	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
662755005113	dimer interface [polypeptide binding]; other site
662755005114	putative functional site; other site
662755005115	putative MPT binding site; other site
662755005116	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
662755005117	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
662755005118	active site
662755005119	tetramer interface; other site
662755005120	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
662755005121	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
662755005122	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
662755005123	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
662755005124	MPT binding site; other site
662755005125	trimer interface [polypeptide binding]; other site
662755005126	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
662755005127	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
662755005128	protein binding site [polypeptide binding]; other site
662755005129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
662755005130	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
662755005131	dimerization interface [polypeptide binding]; other site
662755005132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
662755005133	dimer interface [polypeptide binding]; other site
662755005134	phosphorylation site [posttranslational modification]
662755005135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755005136	ATP binding site [chemical binding]; other site
662755005137	G-X-G motif; other site
662755005138	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
662755005139	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
662755005140	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
662755005141	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
662755005142	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
662755005143	30S ribosomal protein S18; Provisional; Region: PRK13401
662755005144	RDD family; Region: RDD; pfam06271
662755005145	Predicted permeases [General function prediction only]; Region: COG0679
662755005146	putative acyltransferase; Provisional; Region: PRK05790
662755005147	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
662755005148	dimer interface [polypeptide binding]; other site
662755005149	active site
662755005150	AMP-binding domain protein; Validated; Region: PRK08315
662755005151	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755005152	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
662755005153	acyl-activating enzyme (AAE) consensus motif; other site
662755005154	putative AMP binding site [chemical binding]; other site
662755005155	putative active site [active]
662755005156	putative CoA binding site [chemical binding]; other site
662755005157	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
662755005158	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
662755005159	putative active site [active]
662755005160	putative catalytic site [active]
662755005161	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755005162	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755005163	active site
662755005164	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
662755005165	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
662755005166	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
662755005167	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
662755005168	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
662755005169	carboxyltransferase (CT) interaction site; other site
662755005170	biotinylation site [posttranslational modification]; other site
662755005171	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
662755005172	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
662755005173	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
662755005174	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
662755005175	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
662755005176	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
662755005177	purine monophosphate binding site [chemical binding]; other site
662755005178	dimer interface [polypeptide binding]; other site
662755005179	putative catalytic residues [active]
662755005180	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
662755005181	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
662755005182	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
662755005183	active site
662755005184	substrate binding site [chemical binding]; other site
662755005185	cosubstrate binding site; other site
662755005186	catalytic site [active]
662755005187	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
662755005188	Peptidase family M23; Region: Peptidase_M23; pfam01551
662755005189	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
662755005190	Part of AAA domain; Region: AAA_19; pfam13245
662755005191	Family description; Region: UvrD_C_2; pfam13538
662755005192	hypothetical protein; Provisional; Region: PRK07857
662755005193	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
662755005194	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
662755005195	active site
662755005196	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
662755005197	Nucleoside recognition; Region: Gate; pfam07670
662755005198	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
662755005199	Nucleoside recognition; Region: Gate; pfam07670
662755005200	Homeodomain-like domain; Region: HTH_23; pfam13384
662755005201	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755005202	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755005203	Integrase core domain; Region: rve; pfam00665
662755005204	MULE transposase domain; Region: MULE; pfam10551
662755005205	hypothetical protein; Validated; Region: PRK00068
662755005206	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
662755005207	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
662755005208	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
662755005209	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
662755005210	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
662755005211	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
662755005212	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
662755005213	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
662755005214	Part of AAA domain; Region: AAA_19; pfam13245
662755005215	Family description; Region: UvrD_C_2; pfam13538
662755005216	HRDC domain; Region: HRDC; pfam00570
662755005217	Ion channel; Region: Ion_trans_2; pfam07885
662755005218	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
662755005219	TrkA-N domain; Region: TrkA_N; pfam02254
662755005220	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
662755005221	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
662755005222	Family description; Region: UvrD_C_2; pfam13538
662755005223	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
662755005224	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
662755005225	Part of AAA domain; Region: AAA_19; pfam13245
662755005226	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
662755005227	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
662755005228	TIGR02569 family protein; Region: TIGR02569_actnb
662755005229	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
662755005230	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
662755005231	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
662755005232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
662755005233	ATP binding site [chemical binding]; other site
662755005234	putative Mg++ binding site [ion binding]; other site
662755005235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
662755005236	nucleotide binding region [chemical binding]; other site
662755005237	ATP-binding site [chemical binding]; other site
662755005238	Transcription factor WhiB; Region: Whib; pfam02467
662755005239	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
662755005240	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
662755005241	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755005242	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755005243	DNA binding residues [nucleotide binding]
662755005244	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
662755005245	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
662755005246	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
662755005247	hinge; other site
662755005248	active site
662755005249	Predicted GTPases [General function prediction only]; Region: COG1162
662755005250	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
662755005251	GTPase/Zn-binding domain interface [polypeptide binding]; other site
662755005252	GTP/Mg2+ binding site [chemical binding]; other site
662755005253	G4 box; other site
662755005254	G5 box; other site
662755005255	G1 box; other site
662755005256	Switch I region; other site
662755005257	G2 box; other site
662755005258	G3 box; other site
662755005259	Switch II region; other site
662755005260	AzlC protein; Region: AzlC; pfam03591
662755005261	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
662755005262	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
662755005263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
662755005264	ATP binding site [chemical binding]; other site
662755005265	putative Mg++ binding site [ion binding]; other site
662755005266	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
662755005267	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
662755005268	nucleotide binding region [chemical binding]; other site
662755005269	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
662755005270	30S subunit binding site; other site
662755005271	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
662755005272	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755005273	active site
662755005274	lipoprotein LpqB; Provisional; Region: PRK13616
662755005275	Sporulation and spore germination; Region: Germane; pfam10646
662755005276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
662755005277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
662755005278	dimerization interface [polypeptide binding]; other site
662755005279	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
662755005280	dimer interface [polypeptide binding]; other site
662755005281	phosphorylation site [posttranslational modification]
662755005282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755005283	ATP binding site [chemical binding]; other site
662755005284	Mg2+ binding site [ion binding]; other site
662755005285	G-X-G motif; other site
662755005286	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
662755005287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755005288	active site
662755005289	phosphorylation site [posttranslational modification]
662755005290	intermolecular recognition site; other site
662755005291	dimerization interface [polypeptide binding]; other site
662755005292	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
662755005293	DNA binding site [nucleotide binding]
662755005294	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
662755005295	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
662755005296	TMP-binding site; other site
662755005297	ATP-binding site [chemical binding]; other site
662755005298	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
662755005299	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
662755005300	ligand binding site [chemical binding]; other site
662755005301	catalytic site [active]
662755005302	NAD binding site [chemical binding]; other site
662755005303	homotetramer interface [polypeptide binding]; other site
662755005304	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
662755005305	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
662755005306	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
662755005307	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
662755005308	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
662755005309	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
662755005310	active site
662755005311	substrate binding site [chemical binding]; other site
662755005312	metal binding site [ion binding]; metal-binding site
662755005313	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
662755005314	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
662755005315	Transcription factor WhiB; Region: Whib; pfam02467
662755005316	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
662755005317	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
662755005318	active site
662755005319	Substrate binding site; other site
662755005320	Mg++ binding site; other site
662755005321	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
662755005322	putative trimer interface [polypeptide binding]; other site
662755005323	putative CoA binding site [chemical binding]; other site
662755005324	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
662755005325	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
662755005326	Probable Catalytic site; other site
662755005327	metal-binding site
662755005328	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
662755005329	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
662755005330	NADP binding site [chemical binding]; other site
662755005331	active site
662755005332	putative substrate binding site [chemical binding]; other site
662755005333	Transcriptional regulator [Transcription]; Region: LytR; COG1316
662755005334	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
662755005335	TIGR03089 family protein; Region: TIGR03089
662755005336	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
662755005337	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
662755005338	Walker A/P-loop; other site
662755005339	ATP binding site [chemical binding]; other site
662755005340	Q-loop/lid; other site
662755005341	ABC transporter signature motif; other site
662755005342	Walker B; other site
662755005343	D-loop; other site
662755005344	H-loop/switch region; other site
662755005345	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755005346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755005347	active site
662755005348	phosphorylation site [posttranslational modification]
662755005349	intermolecular recognition site; other site
662755005350	dimerization interface [polypeptide binding]; other site
662755005351	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755005352	DNA binding residues [nucleotide binding]
662755005353	dimerization interface [polypeptide binding]; other site
662755005354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
662755005355	Histidine kinase; Region: HisKA_3; pfam07730
662755005356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755005357	ATP binding site [chemical binding]; other site
662755005358	Mg2+ binding site [ion binding]; other site
662755005359	G-X-G motif; other site
662755005360	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
662755005361	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
662755005362	Walker A/P-loop; other site
662755005363	ATP binding site [chemical binding]; other site
662755005364	Q-loop/lid; other site
662755005365	ABC transporter signature motif; other site
662755005366	Walker B; other site
662755005367	D-loop; other site
662755005368	H-loop/switch region; other site
662755005369	TOBE domain; Region: TOBE_2; pfam08402
662755005370	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
662755005371	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
662755005372	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
662755005373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755005374	dimer interface [polypeptide binding]; other site
662755005375	conserved gate region; other site
662755005376	putative PBP binding loops; other site
662755005377	ABC-ATPase subunit interface; other site
662755005378	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
662755005379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755005380	dimer interface [polypeptide binding]; other site
662755005381	conserved gate region; other site
662755005382	putative PBP binding loops; other site
662755005383	ABC-ATPase subunit interface; other site
662755005384	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
662755005385	putative active site [active]
662755005386	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
662755005387	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
662755005388	ATP-grasp domain; Region: ATP-grasp; pfam02222
662755005389	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
662755005390	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
662755005391	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
662755005392	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
662755005393	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
662755005394	Maf-like protein; Region: Maf; pfam02545
662755005395	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
662755005396	active site
662755005397	dimer interface [polypeptide binding]; other site
662755005398	citrate synthase; Provisional; Region: PRK14033
662755005399	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
662755005400	dimer interface [polypeptide binding]; other site
662755005401	active site
662755005402	citrylCoA binding site [chemical binding]; other site
662755005403	oxalacetate/citrate binding site [chemical binding]; other site
662755005404	coenzyme A binding site [chemical binding]; other site
662755005405	catalytic triad [active]
662755005406	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
662755005407	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
662755005408	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
662755005409	active site residue [active]
662755005410	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
662755005411	active site residue [active]
662755005412	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
662755005413	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
662755005414	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
662755005415	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
662755005416	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
662755005417	carboxyltransferase (CT) interaction site; other site
662755005418	biotinylation site [posttranslational modification]; other site
662755005419	potential frameshift: common BLAST hit: gi|68536761|ref|YP_251466.1| putative glycerol kinase
662755005420	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
662755005421	nucleotide binding site [chemical binding]; other site
662755005422	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
662755005423	nucleotide binding site [chemical binding]; other site
662755005424	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
662755005425	Predicted membrane protein [Function unknown]; Region: COG2261
662755005426	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
662755005427	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
662755005428	NAD(P) binding site [chemical binding]; other site
662755005429	catalytic residues [active]
662755005430	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
662755005431	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
662755005432	metal binding site [ion binding]; metal-binding site
662755005433	putative dimer interface [polypeptide binding]; other site
662755005434	purine nucleoside phosphorylase; Provisional; Region: PRK08202
662755005435	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
662755005436	active site
662755005437	substrate binding site [chemical binding]; other site
662755005438	metal binding site [ion binding]; metal-binding site
662755005439	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
662755005440	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
662755005441	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
662755005442	putative DNA binding site [nucleotide binding]; other site
662755005443	putative Zn2+ binding site [ion binding]; other site
662755005444	AsnC family; Region: AsnC_trans_reg; pfam01037
662755005445	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
662755005446	active site
662755005447	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
662755005448	NlpC/P60 family; Region: NLPC_P60; pfam00877
662755005449	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
662755005450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755005451	Walker A/P-loop; other site
662755005452	ATP binding site [chemical binding]; other site
662755005453	Q-loop/lid; other site
662755005454	ABC transporter signature motif; other site
662755005455	Walker B; other site
662755005456	D-loop; other site
662755005457	H-loop/switch region; other site
662755005458	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
662755005459	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
662755005460	TM-ABC transporter signature motif; other site
662755005461	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
662755005462	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
662755005463	putative ligand binding site [chemical binding]; other site
662755005464	adenosine deaminase; Provisional; Region: PRK09358
662755005465	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
662755005466	active site
662755005467	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
662755005468	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
662755005469	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
662755005470	active site
662755005471	HIGH motif; other site
662755005472	dimer interface [polypeptide binding]; other site
662755005473	KMSKS motif; other site
662755005474	hypothetical protein; Provisional; Region: PRK10578
662755005475	UPF0126 domain; Region: UPF0126; pfam03458
662755005476	UPF0126 domain; Region: UPF0126; pfam03458
662755005477	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
662755005478	putative catalytic site [active]
662755005479	putative metal binding site [ion binding]; other site
662755005480	putative phosphate binding site [ion binding]; other site
662755005481	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
662755005482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755005483	putative substrate translocation pore; other site
662755005484	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
662755005485	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
662755005486	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
662755005487	CoA binding domain; Region: CoA_binding; smart00881
662755005488	CoA-ligase; Region: Ligase_CoA; pfam00549
662755005489	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
662755005490	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
662755005491	CoA-ligase; Region: Ligase_CoA; pfam00549
662755005492	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
662755005493	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
662755005494	homodimer interface [polypeptide binding]; other site
662755005495	substrate-cofactor binding pocket; other site
662755005496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755005497	catalytic residue [active]
662755005498	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
662755005499	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
662755005500	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
662755005501	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
662755005502	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
662755005503	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
662755005504	homodimer interface [polypeptide binding]; other site
662755005505	NADP binding site [chemical binding]; other site
662755005506	substrate binding site [chemical binding]; other site
662755005507	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
662755005508	Uncharacterized conserved protein [Function unknown]; Region: COG3268
662755005509	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755005510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
662755005511	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
662755005512	hypothetical protein; Provisional; Region: PRK06547
662755005513	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
662755005514	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
662755005515	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755005516	Walker A/P-loop; other site
662755005517	ATP binding site [chemical binding]; other site
662755005518	Q-loop/lid; other site
662755005519	ABC transporter signature motif; other site
662755005520	Walker B; other site
662755005521	D-loop; other site
662755005522	H-loop/switch region; other site
662755005523	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
662755005524	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
662755005525	Walker A/P-loop; other site
662755005526	ATP binding site [chemical binding]; other site
662755005527	Q-loop/lid; other site
662755005528	ABC transporter signature motif; other site
662755005529	Walker B; other site
662755005530	D-loop; other site
662755005531	H-loop/switch region; other site
662755005532	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
662755005533	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
662755005534	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
662755005535	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
662755005536	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
662755005537	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
662755005538	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
662755005539	active site
662755005540	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
662755005541	generic binding surface II; other site
662755005542	generic binding surface I; other site
662755005543	T5orf172 domain; Region: T5orf172; pfam10544
662755005544	DEAD-like helicases superfamily; Region: DEXDc; smart00487
662755005545	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755005546	ATP binding site [chemical binding]; other site
662755005547	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
662755005548	putative Mg++ binding site [ion binding]; other site
662755005549	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
662755005550	Methyltransferase domain; Region: Methyltransf_26; pfam13659
662755005551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755005552	non-specific DNA binding site [nucleotide binding]; other site
662755005553	salt bridge; other site
662755005554	sequence-specific DNA binding site [nucleotide binding]; other site
662755005555	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
662755005556	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
662755005557	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
662755005558	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
662755005559	Walker A/P-loop; other site
662755005560	ATP binding site [chemical binding]; other site
662755005561	Q-loop/lid; other site
662755005562	ABC transporter signature motif; other site
662755005563	Walker B; other site
662755005564	D-loop; other site
662755005565	H-loop/switch region; other site
662755005566	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
662755005567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
662755005568	dimer interface [polypeptide binding]; other site
662755005569	conserved gate region; other site
662755005570	putative PBP binding loops; other site
662755005571	ABC-ATPase subunit interface; other site
662755005572	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
662755005573	putative dimer interface [polypeptide binding]; other site
662755005574	putative [2Fe-2S] cluster binding site [ion binding]; other site
662755005575	DNA Polymerase Y-family; Region: PolY_like; cd03468
662755005576	active site
662755005577	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
662755005578	DNA binding site [nucleotide binding]
662755005579	GMP synthase; Reviewed; Region: guaA; PRK00074
662755005580	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
662755005581	AMP/PPi binding site [chemical binding]; other site
662755005582	candidate oxyanion hole; other site
662755005583	catalytic triad [active]
662755005584	potential glutamine specificity residues [chemical binding]; other site
662755005585	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
662755005586	ATP Binding subdomain [chemical binding]; other site
662755005587	Ligand Binding sites [chemical binding]; other site
662755005588	Dimerization subdomain; other site
662755005589	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
662755005590	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
662755005591	phosphate binding site [ion binding]; other site
662755005592	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
662755005593	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
662755005594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
662755005595	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
662755005596	active site
662755005597	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
662755005598	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755005599	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755005600	DNA binding residues [nucleotide binding]
662755005601	Transcription factor WhiB; Region: Whib; pfam02467
662755005602	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
662755005603	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
662755005604	ring oligomerisation interface [polypeptide binding]; other site
662755005605	ATP/Mg binding site [chemical binding]; other site
662755005606	stacking interactions; other site
662755005607	hinge regions; other site
662755005608	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
662755005609	oligomerisation interface [polypeptide binding]; other site
662755005610	mobile loop; other site
662755005611	roof hairpin; other site
662755005612	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
662755005613	Glycoprotease family; Region: Peptidase_M22; pfam00814
662755005614	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
662755005615	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
662755005616	Coenzyme A binding pocket [chemical binding]; other site
662755005617	UGMP family protein; Validated; Region: PRK09604
662755005618	alanine racemase; Reviewed; Region: alr; PRK00053
662755005619	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
662755005620	active site
662755005621	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
662755005622	dimer interface [polypeptide binding]; other site
662755005623	substrate binding site [chemical binding]; other site
662755005624	catalytic residues [active]
662755005625	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
662755005626	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
662755005627	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
662755005628	glutaminase active site [active]
662755005629	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
662755005630	dimer interface [polypeptide binding]; other site
662755005631	active site
662755005632	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
662755005633	dimer interface [polypeptide binding]; other site
662755005634	active site
662755005635	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
662755005636	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
662755005637	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
662755005638	active site
662755005639	substrate binding site [chemical binding]; other site
662755005640	metal binding site [ion binding]; metal-binding site
662755005641	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
662755005642	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
662755005643	23S rRNA interface [nucleotide binding]; other site
662755005644	L3 interface [polypeptide binding]; other site
662755005645	PRC-barrel domain; Region: PRC; pfam05239
662755005646	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
662755005647	Proteins of 100 residues with WXG; Region: WXG100; cl02005
662755005648	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
662755005649	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
662755005650	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
662755005651	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
662755005652	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
662755005653	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
662755005654	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
662755005655	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
662755005656	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
662755005657	active site
662755005658	catalytic residues [active]
662755005659	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
662755005660	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
662755005661	dimerization interface 3.5A [polypeptide binding]; other site
662755005662	active site
662755005663	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
662755005664	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
662755005665	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
662755005666	alphaNTD - beta interaction site [polypeptide binding]; other site
662755005667	alphaNTD homodimer interface [polypeptide binding]; other site
662755005668	alphaNTD - beta' interaction site [polypeptide binding]; other site
662755005669	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
662755005670	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
662755005671	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
662755005672	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
662755005673	RNA binding surface [nucleotide binding]; other site
662755005674	30S ribosomal protein S11; Validated; Region: PRK05309
662755005675	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
662755005676	30S ribosomal protein S13; Region: bact_S13; TIGR03631
662755005677	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
662755005678	rRNA binding site [nucleotide binding]; other site
662755005679	predicted 30S ribosome binding site; other site
662755005680	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
662755005681	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
662755005682	methionine aminopeptidase; Provisional; Region: PRK12318
662755005683	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
662755005684	active site
662755005685	adenylate kinase; Reviewed; Region: adk; PRK00279
662755005686	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
662755005687	AMP-binding site [chemical binding]; other site
662755005688	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
662755005689	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
662755005690	SecY translocase; Region: SecY; pfam00344
662755005691	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
662755005692	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
662755005693	23S rRNA binding site [nucleotide binding]; other site
662755005694	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
662755005695	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
662755005696	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
662755005697	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
662755005698	23S rRNA interface [nucleotide binding]; other site
662755005699	L21e interface [polypeptide binding]; other site
662755005700	5S rRNA interface [nucleotide binding]; other site
662755005701	L27 interface [polypeptide binding]; other site
662755005702	L5 interface [polypeptide binding]; other site
662755005703	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
662755005704	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
662755005705	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
662755005706	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
662755005707	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755005708	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755005709	ABC-ATPase subunit  interface; other site
662755005710	dimer interface [polypeptide binding]; other site
662755005711	putative PBP binding regions; other site
662755005712	Transposase; Region: DEDD_Tnp_IS110; pfam01548
662755005713	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
662755005714	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
662755005715	multiple promoter invertase; Provisional; Region: mpi; PRK13413
662755005716	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
662755005717	catalytic residues [active]
662755005718	catalytic nucleophile [active]
662755005719	Presynaptic Site I dimer interface [polypeptide binding]; other site
662755005720	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
662755005721	Synaptic Flat tetramer interface [polypeptide binding]; other site
662755005722	Synaptic Site I dimer interface [polypeptide binding]; other site
662755005723	DNA binding site [nucleotide binding]
662755005724	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
662755005725	DNA-binding interface [nucleotide binding]; DNA binding site
662755005726	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
662755005727	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
662755005728	active site
662755005729	ATP binding site [chemical binding]; other site
662755005730	substrate binding site [chemical binding]; other site
662755005731	activation loop (A-loop); other site
662755005732	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
662755005733	active site
662755005734	zinc binding site [ion binding]; other site
662755005735	FtsX-like permease family; Region: FtsX; pfam02687
662755005736	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
662755005737	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
662755005738	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755005739	Walker A/P-loop; other site
662755005740	ATP binding site [chemical binding]; other site
662755005741	Q-loop/lid; other site
662755005742	ABC transporter signature motif; other site
662755005743	Walker B; other site
662755005744	D-loop; other site
662755005745	H-loop/switch region; other site
662755005746	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
662755005747	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
662755005748	Walker A/P-loop; other site
662755005749	ATP binding site [chemical binding]; other site
662755005750	Q-loop/lid; other site
662755005751	ABC transporter signature motif; other site
662755005752	Walker B; other site
662755005753	D-loop; other site
662755005754	H-loop/switch region; other site
662755005755	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755005756	ABC-ATPase subunit  interface; other site
662755005757	dimer interface [polypeptide binding]; other site
662755005758	putative PBP binding regions; other site
662755005759	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
662755005760	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
662755005761	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755005762	ABC-ATPase subunit  interface; other site
662755005763	dimer interface [polypeptide binding]; other site
662755005764	putative PBP binding regions; other site
662755005765	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
662755005766	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
662755005767	siderophore binding site; other site
662755005768	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
662755005769	FAD binding pocket [chemical binding]; other site
662755005770	FAD binding motif [chemical binding]; other site
662755005771	phosphate binding motif [ion binding]; other site
662755005772	NAD binding pocket [chemical binding]; other site
662755005773	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
662755005774	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
662755005775	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
662755005776	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
662755005777	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
662755005778	RNA binding site [nucleotide binding]; other site
662755005779	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
662755005780	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
662755005781	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
662755005782	putative translocon interaction site; other site
662755005783	signal recognition particle (SRP54) interaction site; other site
662755005784	L23 interface [polypeptide binding]; other site
662755005785	trigger factor interaction site; other site
662755005786	23S rRNA interface [nucleotide binding]; other site
662755005787	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
662755005788	23S rRNA interface [nucleotide binding]; other site
662755005789	5S rRNA interface [nucleotide binding]; other site
662755005790	putative antibiotic binding site [chemical binding]; other site
662755005791	L25 interface [polypeptide binding]; other site
662755005792	L27 interface [polypeptide binding]; other site
662755005793	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
662755005794	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
662755005795	G-X-X-G motif; other site
662755005796	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
662755005797	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
662755005798	putative translocon binding site; other site
662755005799	protein-rRNA interface [nucleotide binding]; other site
662755005800	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
662755005801	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
662755005802	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
662755005803	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
662755005804	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
662755005805	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
662755005806	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
662755005807	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
662755005808	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
662755005809	active site
662755005810	catalytic site [active]
662755005811	MULE transposase domain; Region: MULE; pfam10551
662755005812	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
662755005813	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
662755005814	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
662755005815	putative homodimer interface [polypeptide binding]; other site
662755005816	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
662755005817	heterodimer interface [polypeptide binding]; other site
662755005818	homodimer interface [polypeptide binding]; other site
662755005819	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
662755005820	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
662755005821	23S rRNA interface [nucleotide binding]; other site
662755005822	L7/L12 interface [polypeptide binding]; other site
662755005823	putative thiostrepton binding site; other site
662755005824	L25 interface [polypeptide binding]; other site
662755005825	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
662755005826	mRNA/rRNA interface [nucleotide binding]; other site
662755005827	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
662755005828	Lipase (class 2); Region: Lipase_2; pfam01674
662755005829	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
662755005830	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
662755005831	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
662755005832	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
662755005833	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755005834	intersubunit interface [polypeptide binding]; other site
662755005835	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
662755005836	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
662755005837	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
662755005838	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
662755005839	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
662755005840	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
662755005841	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
662755005842	dimer interface [polypeptide binding]; other site
662755005843	ABC-ATPase subunit  interface; other site
662755005844	putative PBP binding regions; other site
662755005845	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
662755005846	23S rRNA interface [nucleotide binding]; other site
662755005847	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
662755005848	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
662755005849	peripheral dimer interface [polypeptide binding]; other site
662755005850	core dimer interface [polypeptide binding]; other site
662755005851	L10 interface [polypeptide binding]; other site
662755005852	L11 interface [polypeptide binding]; other site
662755005853	putative EF-Tu interaction site [polypeptide binding]; other site
662755005854	putative EF-G interaction site [polypeptide binding]; other site
662755005855	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
662755005856	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
662755005857	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
662755005858	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
662755005859	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
662755005860	RPB1 interaction site [polypeptide binding]; other site
662755005861	RPB10 interaction site [polypeptide binding]; other site
662755005862	RPB11 interaction site [polypeptide binding]; other site
662755005863	RPB3 interaction site [polypeptide binding]; other site
662755005864	RPB12 interaction site [polypeptide binding]; other site
662755005865	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
662755005866	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
662755005867	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
662755005868	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
662755005869	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
662755005870	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
662755005871	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
662755005872	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
662755005873	DNA binding site [nucleotide binding]
662755005874	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
662755005875	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
662755005876	Lipase (class 2); Region: Lipase_2; pfam01674
662755005877	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
662755005878	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
662755005879	S17 interaction site [polypeptide binding]; other site
662755005880	S8 interaction site; other site
662755005881	16S rRNA interaction site [nucleotide binding]; other site
662755005882	streptomycin interaction site [chemical binding]; other site
662755005883	23S rRNA interaction site [nucleotide binding]; other site
662755005884	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
662755005885	30S ribosomal protein S7; Validated; Region: PRK05302
662755005886	elongation factor G; Reviewed; Region: PRK00007
662755005887	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
662755005888	G1 box; other site
662755005889	putative GEF interaction site [polypeptide binding]; other site
662755005890	GTP/Mg2+ binding site [chemical binding]; other site
662755005891	Switch I region; other site
662755005892	G2 box; other site
662755005893	G3 box; other site
662755005894	Switch II region; other site
662755005895	G4 box; other site
662755005896	G5 box; other site
662755005897	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
662755005898	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
662755005899	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
662755005900	elongation factor Tu; Reviewed; Region: PRK00049
662755005901	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
662755005902	G1 box; other site
662755005903	GEF interaction site [polypeptide binding]; other site
662755005904	GTP/Mg2+ binding site [chemical binding]; other site
662755005905	Switch I region; other site
662755005906	G2 box; other site
662755005907	G3 box; other site
662755005908	Switch II region; other site
662755005909	G4 box; other site
662755005910	G5 box; other site
662755005911	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
662755005912	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
662755005913	Antibiotic Binding Site [chemical binding]; other site
662755005914	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
662755005915	MULE transposase domain; Region: MULE; pfam10551
662755005916	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
662755005917	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
662755005918	substrate binding pocket [chemical binding]; other site
662755005919	chain length determination region; other site
662755005920	substrate-Mg2+ binding site; other site
662755005921	catalytic residues [active]
662755005922	aspartate-rich region 1; other site
662755005923	active site lid residues [active]
662755005924	aspartate-rich region 2; other site
662755005925	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
662755005926	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
662755005927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
662755005928	S-adenosylmethionine binding site [chemical binding]; other site
662755005929	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
662755005930	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
662755005931	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
662755005932	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
662755005933	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
662755005934	dimer interface [polypeptide binding]; other site
662755005935	tetramer interface [polypeptide binding]; other site
662755005936	PYR/PP interface [polypeptide binding]; other site
662755005937	TPP binding site [chemical binding]; other site
662755005938	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
662755005939	TPP-binding site; other site
662755005940	O-succinylbenzoate synthase; Provisional; Region: PRK02901
662755005941	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
662755005942	metal binding site [ion binding]; metal-binding site
662755005943	substrate binding pocket [chemical binding]; other site
662755005944	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755005945	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
662755005946	substrate binding site [chemical binding]; other site
662755005947	oxyanion hole (OAH) forming residues; other site
662755005948	trimer interface [polypeptide binding]; other site
662755005949	Predicted membrane protein [Function unknown]; Region: COG2259
662755005950	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755005951	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
662755005952	acyl-activating enzyme (AAE) consensus motif; other site
662755005953	AMP binding site [chemical binding]; other site
662755005954	active site
662755005955	CoA binding site [chemical binding]; other site
662755005956	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
662755005957	UbiA prenyltransferase family; Region: UbiA; pfam01040
662755005958	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
662755005959	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
662755005960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755005961	putative substrate translocation pore; other site
662755005962	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
662755005963	Phosphotransferase enzyme family; Region: APH; pfam01636
662755005964	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
662755005965	ATP binding site [chemical binding]; other site
662755005966	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
662755005967	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
662755005968	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
662755005969	substrate binding site; other site
662755005970	tetramer interface; other site
662755005971	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
662755005972	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
662755005973	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
662755005974	Walker A/P-loop; other site
662755005975	ATP binding site [chemical binding]; other site
662755005976	Q-loop/lid; other site
662755005977	ABC transporter signature motif; other site
662755005978	Walker B; other site
662755005979	D-loop; other site
662755005980	H-loop/switch region; other site
662755005981	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
662755005982	dimer interface [polypeptide binding]; other site
662755005983	putative PBP binding regions; other site
662755005984	ABC-ATPase subunit  interface; other site
662755005985	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
662755005986	Integrase core domain; Region: rve; pfam00665
662755005987	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
662755005988	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
662755005989	NAD binding site [chemical binding]; other site
662755005990	substrate binding site [chemical binding]; other site
662755005991	homodimer interface [polypeptide binding]; other site
662755005992	active site
662755005993	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
662755005994	ResB-like family; Region: ResB; pfam05140
662755005995	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
662755005996	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
662755005997	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
662755005998	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
662755005999	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
662755006000	catalytic residues [active]
662755006001	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755006002	catalytic core [active]
662755006003	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
662755006004	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
662755006005	inhibitor-cofactor binding pocket; inhibition site
662755006006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755006007	catalytic residue [active]
662755006008	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
662755006009	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
662755006010	Soluble P-type ATPase [General function prediction only]; Region: COG4087
662755006011	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
662755006012	dimer interface [polypeptide binding]; other site
662755006013	active site
662755006014	Schiff base residues; other site
662755006015	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
662755006016	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
662755006017	active site
662755006018	SAM binding site [chemical binding]; other site
662755006019	homodimer interface [polypeptide binding]; other site
662755006020	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
662755006021	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
662755006022	active site
662755006023	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
662755006024	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
662755006025	domain interfaces; other site
662755006026	active site
662755006027	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
662755006028	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
662755006029	tRNA; other site
662755006030	putative tRNA binding site [nucleotide binding]; other site
662755006031	putative NADP binding site [chemical binding]; other site
662755006032	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
662755006033	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
662755006034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
662755006035	motif II; other site
662755006036	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
662755006037	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
662755006038	exopolyphosphatase; Region: exo_poly_only; TIGR03706
662755006039	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
662755006040	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
662755006041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755006042	active site
662755006043	phosphorylation site [posttranslational modification]
662755006044	intermolecular recognition site; other site
662755006045	dimerization interface [polypeptide binding]; other site
662755006046	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
662755006047	DNA binding site [nucleotide binding]
662755006048	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
662755006049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
662755006050	dimer interface [polypeptide binding]; other site
662755006051	phosphorylation site [posttranslational modification]
662755006052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
662755006053	ATP binding site [chemical binding]; other site
662755006054	G-X-G motif; other site
662755006055	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
662755006056	catalytic core [active]
662755006057	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
662755006058	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
662755006059	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
662755006060	active site
662755006061	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
662755006062	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
662755006063	putative ADP-binding pocket [chemical binding]; other site
662755006064	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
662755006065	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755006066	acyl-activating enzyme (AAE) consensus motif; other site
662755006067	AMP binding site [chemical binding]; other site
662755006068	active site
662755006069	CoA binding site [chemical binding]; other site
662755006070	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
662755006071	FAD binding domain; Region: FAD_binding_4; pfam01565
662755006072	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
662755006073	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
662755006074	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
662755006075	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
662755006076	intersubunit interface [polypeptide binding]; other site
662755006077	active site
662755006078	catalytic residue [active]
662755006079	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
662755006080	Predicted membrane protein [Function unknown]; Region: COG2733
662755006081	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
662755006082	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
662755006083	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
662755006084	L-aspartate oxidase; Provisional; Region: PRK06175
662755006085	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
662755006086	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
662755006087	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
662755006088	putative Iron-sulfur protein interface [polypeptide binding]; other site
662755006089	proximal heme binding site [chemical binding]; other site
662755006090	distal heme binding site [chemical binding]; other site
662755006091	putative dimer interface [polypeptide binding]; other site
662755006092	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
662755006093	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
662755006094	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
662755006095	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
662755006096	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
662755006097	malate synthase G; Provisional; Region: PRK02999
662755006098	active site
662755006099	isocitrate lyase; Provisional; Region: PRK15063
662755006100	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
662755006101	tetramer interface [polypeptide binding]; other site
662755006102	active site
662755006103	Mg2+/Mn2+ binding site [ion binding]; other site
662755006104	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
662755006105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
662755006106	non-specific DNA binding site [nucleotide binding]; other site
662755006107	salt bridge; other site
662755006108	sequence-specific DNA binding site [nucleotide binding]; other site
662755006109	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
662755006110	Domain of unknown function (DUF955); Region: DUF955; pfam06114
662755006111	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
662755006112	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
662755006113	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
662755006114	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
662755006115	Predicted esterase [General function prediction only]; Region: COG0627
662755006116	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
662755006117	Zn binding site [ion binding]; other site
662755006118	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
662755006119	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755006120	active site
662755006121	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755006122	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
662755006123	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
662755006124	Ligand binding site; other site
662755006125	Putative Catalytic site; other site
662755006126	DXD motif; other site
662755006127	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
662755006128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
662755006129	acyl-CoA oxidase; Region: PLN02312
662755006130	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755006131	active site
662755006132	diacylglycerol kinase; Reviewed; Region: PRK11914
662755006133	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
662755006134	AAA ATPase domain; Region: AAA_16; pfam13191
662755006135	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
662755006136	FAD binding domain; Region: FAD_binding_4; pfam01565
662755006137	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
662755006138	Transposase, Mutator family; Region: Transposase_mut; pfam00872
662755006139	MULE transposase domain; Region: MULE; pfam10551
662755006140	The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921
662755006141	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
662755006142	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
662755006143	putative acyl-acceptor binding pocket; other site
662755006144	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
662755006145	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
662755006146	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
662755006147	Transcriptional regulators [Transcription]; Region: MarR; COG1846
662755006148	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
662755006149	Transposase, Mutator family; Region: Transposase_mut; pfam00872
662755006150	MULE transposase domain; Region: MULE; pfam10551
662755006151	DNA polymerase III subunit delta'; Validated; Region: PRK07940
662755006152	DNA polymerase III subunit delta'; Validated; Region: PRK08485
662755006153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
662755006154	dimerization interface [polypeptide binding]; other site
662755006155	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
662755006156	cyclase homology domain; Region: CHD; cd07302
662755006157	nucleotidyl binding site; other site
662755006158	metal binding site [ion binding]; metal-binding site
662755006159	dimer interface [polypeptide binding]; other site
662755006160	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
662755006161	CoA-transferase family III; Region: CoA_transf_3; pfam02515
662755006162	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
662755006163	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
662755006164	active site
662755006165	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
662755006166	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
662755006167	active site
662755006168	interdomain interaction site; other site
662755006169	putative metal-binding site [ion binding]; other site
662755006170	nucleotide binding site [chemical binding]; other site
662755006171	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
662755006172	domain I; other site
662755006173	phosphate binding site [ion binding]; other site
662755006174	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
662755006175	domain II; other site
662755006176	domain III; other site
662755006177	nucleotide binding site [chemical binding]; other site
662755006178	DNA binding groove [nucleotide binding]
662755006179	catalytic site [active]
662755006180	domain IV; other site
662755006181	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
662755006182	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
662755006183	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
662755006184	DNA-binding site [nucleotide binding]; DNA binding site
662755006185	RNA-binding motif; other site
662755006186	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
662755006187	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
662755006188	ATP binding site [chemical binding]; other site
662755006189	putative Mg++ binding site [ion binding]; other site
662755006190	nucleotide binding region [chemical binding]; other site
662755006191	helicase superfamily c-terminal domain; Region: HELICc; smart00490
662755006192	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
662755006193	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
662755006194	Type II/IV secretion system protein; Region: T2SE; pfam00437
662755006195	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
662755006196	ATP binding site [chemical binding]; other site
662755006197	Walker A motif; other site
662755006198	hexamer interface [polypeptide binding]; other site
662755006199	Walker B motif; other site
662755006200	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
662755006201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
662755006202	motif II; other site
662755006203	Fic/DOC family; Region: Fic; pfam02661
662755006204	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
662755006205	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
662755006206	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
662755006207	Colicin V production protein; Region: Colicin_V; pfam02674
662755006208	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
662755006209	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
662755006210	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
662755006211	putative active site [active]
662755006212	putative CoA binding site [chemical binding]; other site
662755006213	nudix motif; other site
662755006214	metal binding site [ion binding]; metal-binding site
662755006215	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
662755006216	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
662755006217	catalytic residues [active]
662755006218	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
662755006219	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
662755006220	minor groove reading motif; other site
662755006221	helix-hairpin-helix signature motif; other site
662755006222	substrate binding pocket [chemical binding]; other site
662755006223	active site
662755006224	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
662755006225	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
662755006226	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
662755006227	ligand binding site [chemical binding]; other site
662755006228	flexible hinge region; other site
662755006229	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
662755006230	putative switch regulator; other site
662755006231	non-specific DNA interactions [nucleotide binding]; other site
662755006232	DNA binding site [nucleotide binding]
662755006233	sequence specific DNA binding site [nucleotide binding]; other site
662755006234	putative cAMP binding site [chemical binding]; other site
662755006235	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
662755006236	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
662755006237	homotrimer interaction site [polypeptide binding]; other site
662755006238	putative active site [active]
662755006239	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
662755006240	Transcription factor WhiB; Region: Whib; pfam02467
662755006241	Transglycosylase; Region: Transgly; pfam00912
662755006242	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
662755006243	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
662755006244	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
662755006245	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
662755006246	putative active site [active]
662755006247	putative metal binding site [ion binding]; other site
662755006248	Transposase, Mutator family; Region: Transposase_mut; pfam00872
662755006249	MULE transposase domain; Region: MULE; pfam10551
662755006250	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
662755006251	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
662755006252	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
662755006253	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
662755006254	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
662755006255	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
662755006256	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
662755006257	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
662755006258	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
662755006259	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
662755006260	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
662755006261	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
662755006262	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
662755006263	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
662755006264	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755006265	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755006266	DNA binding residues [nucleotide binding]
662755006267	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
662755006268	hydrophobic ligand binding site; other site
662755006269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
662755006270	TIGR01777 family protein; Region: yfcH
662755006271	NAD(P) binding site [chemical binding]; other site
662755006272	active site
662755006273	ferrochelatase; Reviewed; Region: hemH; PRK00035
662755006274	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
662755006275	C-terminal domain interface [polypeptide binding]; other site
662755006276	active site
662755006277	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
662755006278	active site
662755006279	N-terminal domain interface [polypeptide binding]; other site
662755006280	Major Facilitator Superfamily; Region: MFS_1; pfam07690
662755006281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006282	putative substrate translocation pore; other site
662755006283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006284	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
662755006285	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
662755006286	aspartate kinase; Reviewed; Region: PRK06635
662755006287	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
662755006288	putative nucleotide binding site [chemical binding]; other site
662755006289	putative catalytic residues [active]
662755006290	putative Mg ion binding site [ion binding]; other site
662755006291	putative aspartate binding site [chemical binding]; other site
662755006292	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
662755006293	putative allosteric regulatory site; other site
662755006294	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
662755006295	putative allosteric regulatory residue; other site
662755006296	Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855
662755006297	Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855
662755006298	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
662755006299	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
662755006300	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
662755006301	DDE domain; Region: DDE_Tnp_IS240; pfam13610
662755006302	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
662755006303	active site
662755006304	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
662755006305	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
662755006306	2-isopropylmalate synthase; Validated; Region: PRK03739
662755006307	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
662755006308	active site
662755006309	catalytic residues [active]
662755006310	metal binding site [ion binding]; metal-binding site
662755006311	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
662755006312	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
662755006313	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
662755006314	active site
662755006315	substrate binding site [chemical binding]; other site
662755006316	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
662755006317	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
662755006318	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
662755006319	catalytic triad [active]
662755006320	Predicted membrane protein [Function unknown]; Region: COG4270
662755006321	recombination protein RecR; Reviewed; Region: recR; PRK00076
662755006322	RecR protein; Region: RecR; pfam02132
662755006323	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
662755006324	putative active site [active]
662755006325	putative metal-binding site [ion binding]; other site
662755006326	tetramer interface [polypeptide binding]; other site
662755006327	hypothetical protein; Validated; Region: PRK00153
662755006328	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
662755006329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
662755006330	Walker A motif; other site
662755006331	ATP binding site [chemical binding]; other site
662755006332	Walker B motif; other site
662755006333	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
662755006334	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
662755006335	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
662755006336	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755006337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755006338	homodimer interface [polypeptide binding]; other site
662755006339	catalytic residue [active]
662755006340	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
662755006341	metal ion-dependent adhesion site (MIDAS); other site
662755006342	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
662755006343	intracellular protease, PfpI family; Region: PfpI; TIGR01382
662755006344	proposed catalytic triad [active]
662755006345	conserved cys residue [active]
662755006346	enoyl-CoA hydratase; Provisional; Region: PRK07509
662755006347	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
662755006348	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
662755006349	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
662755006350	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
662755006351	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
662755006352	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
662755006353	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
662755006354	helicase Cas3; Provisional; Region: PRK09694
662755006355	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
662755006356	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
662755006357	enoyl-CoA hydratase; Provisional; Region: PRK07509
662755006358	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
662755006359	substrate binding site [chemical binding]; other site
662755006360	oxyanion hole (OAH) forming residues; other site
662755006361	trimer interface [polypeptide binding]; other site
662755006362	quinolinate synthetase; Provisional; Region: PRK09375
662755006363	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
662755006364	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
662755006365	dimerization interface [polypeptide binding]; other site
662755006366	active site
662755006367	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
662755006368	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
662755006369	putative active site [active]
662755006370	putative metal binding site [ion binding]; other site
662755006371	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
662755006372	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
662755006373	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
662755006374	active site
662755006375	HIGH motif; other site
662755006376	nucleotide binding site [chemical binding]; other site
662755006377	active site
662755006378	KMSKS motif; other site
662755006379	Homeodomain-like domain; Region: HTH_23; pfam13384
662755006380	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
662755006381	Helix-turn-helix domain; Region: HTH_38; pfam13936
662755006382	Integrase core domain; Region: rve; pfam00665
662755006383	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
662755006384	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
662755006385	beta-galactosidase; Region: BGL; TIGR03356
662755006386	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
662755006387	Major Facilitator Superfamily; Region: MFS_1; pfam07690
662755006388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006389	Major Facilitator Superfamily; Region: MFS_1; pfam07690
662755006390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006391	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
662755006392	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
662755006393	nudix motif; other site
662755006394	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
662755006395	Secretory lipase; Region: LIP; pfam03583
662755006396	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
662755006397	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
662755006398	nucleoside/Zn binding site; other site
662755006399	dimer interface [polypeptide binding]; other site
662755006400	catalytic motif [active]
662755006401	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
662755006402	prephenate dehydrogenase; Validated; Region: PRK06545
662755006403	prephenate dehydrogenase; Validated; Region: PRK08507
662755006404	MULE transposase domain; Region: MULE; pfam10551
662755006405	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
662755006406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
662755006407	homodimer interface [polypeptide binding]; other site
662755006408	catalytic residue [active]
662755006409	Transposase; Region: DEDD_Tnp_IS110; pfam01548
662755006410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
662755006411	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
662755006412	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
662755006413	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
662755006414	NAD(P) binding site [chemical binding]; other site
662755006415	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
662755006416	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
662755006417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
662755006418	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
662755006419	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
662755006420	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
662755006421	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
662755006422	Walker A/P-loop; other site
662755006423	ATP binding site [chemical binding]; other site
662755006424	Q-loop/lid; other site
662755006425	ABC transporter signature motif; other site
662755006426	Walker B; other site
662755006427	D-loop; other site
662755006428	H-loop/switch region; other site
662755006429	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
662755006430	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755006431	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
662755006432	acyl-activating enzyme (AAE) consensus motif; other site
662755006433	AMP binding site [chemical binding]; other site
662755006434	active site
662755006435	CoA binding site [chemical binding]; other site
662755006436	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
662755006437	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
662755006438	active site
662755006439	Predicted membrane protein [Function unknown]; Region: COG2246
662755006440	GtrA-like protein; Region: GtrA; pfam04138
662755006441	Predicted membrane protein [Function unknown]; Region: COG2246
662755006442	GtrA-like protein; Region: GtrA; pfam04138
662755006443	Divergent AAA domain; Region: AAA_4; pfam04326
662755006444	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
662755006445	Helicase associated domain (HA2); Region: HA2; cl04503
662755006446	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
662755006447	agmatinase; Region: agmatinase; TIGR01230
662755006448	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
662755006449	putative active site [active]
662755006450	putative metal binding site [ion binding]; other site
662755006451	Transcriptional regulator [Transcription]; Region: IclR; COG1414
662755006452	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
662755006453	Bacterial transcriptional regulator; Region: IclR; pfam01614
662755006454	imidazolonepropionase; Provisional; Region: PRK14085
662755006455	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
662755006456	active site
662755006457	urocanate hydratase; Provisional; Region: PRK05414
662755006458	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
662755006459	active sites [active]
662755006460	tetramer interface [polypeptide binding]; other site
662755006461	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
662755006462	FAD binding domain; Region: FAD_binding_4; pfam01565
662755006463	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
662755006464	short chain dehydrogenase; Provisional; Region: PRK08251
662755006465	classical (c) SDRs; Region: SDR_c; cd05233
662755006466	NAD(P) binding site [chemical binding]; other site
662755006467	active site
662755006468	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
662755006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006470	putative substrate translocation pore; other site
662755006471	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
662755006472	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
662755006473	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
662755006474	putative NAD(P) binding site [chemical binding]; other site
662755006475	putative substrate binding site [chemical binding]; other site
662755006476	catalytic Zn binding site [ion binding]; other site
662755006477	structural Zn binding site [ion binding]; other site
662755006478	dimer interface [polypeptide binding]; other site
662755006479	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
662755006480	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
662755006481	catalytic residues [active]
662755006482	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
662755006483	CoenzymeA binding site [chemical binding]; other site
662755006484	subunit interaction site [polypeptide binding]; other site
662755006485	PHB binding site; other site
662755006486	CrcB-like protein; Region: CRCB; pfam02537
662755006487	CrcB-like protein; Region: CRCB; pfam02537
662755006488	Transcriptional regulators [Transcription]; Region: MarR; COG1846
662755006489	MarR family; Region: MarR_2; pfam12802
662755006490	replicative DNA helicase; Provisional; Region: PRK05636
662755006491	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
662755006492	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
662755006493	Walker A motif; other site
662755006494	ATP binding site [chemical binding]; other site
662755006495	Walker B motif; other site
662755006496	DNA binding loops [nucleotide binding]
662755006497	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
662755006498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755006499	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
662755006500	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
662755006501	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
662755006502	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
662755006503	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
662755006504	dimer interface [polypeptide binding]; other site
662755006505	ssDNA binding site [nucleotide binding]; other site
662755006506	tetramer (dimer of dimers) interface [polypeptide binding]; other site
662755006507	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
662755006508	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
662755006509	Predicted integral membrane protein [Function unknown]; Region: COG5650
662755006510	Transglycosylase; Region: Transgly; pfam00912
662755006511	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
662755006512	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
662755006513	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
662755006514	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
662755006515	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
662755006516	MarR family; Region: MarR; pfam01047
662755006517	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
662755006518	Ligand Binding Site [chemical binding]; other site
662755006519	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
662755006520	Ligand Binding Site [chemical binding]; other site
662755006521	DNA photolyase; Region: DNA_photolyase; pfam00875
662755006522	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
662755006523	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
662755006524	Transposase, Mutator family; Region: Transposase_mut; pfam00872
662755006525	MULE transposase domain; Region: MULE; pfam10551
662755006526	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
662755006527	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
662755006528	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
662755006529	HIGH motif; other site
662755006530	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
662755006531	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
662755006532	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
662755006533	active site
662755006534	KMSKS motif; other site
662755006535	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
662755006536	tRNA binding surface [nucleotide binding]; other site
662755006537	SdpI/YhfL protein family; Region: SdpI; pfam13630
662755006538	Histidine kinase; Region: HisKA_3; pfam07730
662755006539	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
662755006540	ATP binding site [chemical binding]; other site
662755006541	Mg2+ binding site [ion binding]; other site
662755006542	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
662755006543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
662755006544	active site
662755006545	phosphorylation site [posttranslational modification]
662755006546	intermolecular recognition site; other site
662755006547	dimerization interface [polypeptide binding]; other site
662755006548	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
662755006549	DNA binding residues [nucleotide binding]
662755006550	dimerization interface [polypeptide binding]; other site
662755006551	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
662755006552	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
662755006553	substrate binding site [chemical binding]; other site
662755006554	ATP binding site [chemical binding]; other site
662755006555	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
662755006556	active site
662755006557	tetramer interface [polypeptide binding]; other site
662755006558	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
662755006559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006560	putative substrate translocation pore; other site
662755006561	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
662755006562	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
662755006563	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
662755006564	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
662755006565	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
662755006566	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
662755006567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
662755006568	putative substrate translocation pore; other site
662755006569	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
662755006570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
662755006571	Walker A/P-loop; other site
662755006572	ATP binding site [chemical binding]; other site
662755006573	ABC transporter signature motif; other site
662755006574	Walker B; other site
662755006575	D-loop; other site
662755006576	H-loop/switch region; other site
662755006577	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
662755006578	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
662755006579	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
662755006580	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
662755006581	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
662755006582	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
662755006583	Cysteine-rich domain; Region: CCG; pfam02754
662755006584	Cysteine-rich domain; Region: CCG; pfam02754
662755006585	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
662755006586	nudix motif; other site
662755006587	Sec24-related protein; Provisional; Region: PTZ00395
662755006588	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
662755006589	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
662755006590	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
662755006591	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
662755006592	active site
662755006593	NTP binding site [chemical binding]; other site
662755006594	metal binding triad [ion binding]; metal-binding site
662755006595	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
662755006596	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
662755006597	Zn2+ binding site [ion binding]; other site
662755006598	Mg2+ binding site [ion binding]; other site
662755006599	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
662755006600	active site
662755006601	Ap6A binding site [chemical binding]; other site
662755006602	nudix motif; other site
662755006603	metal binding site [ion binding]; metal-binding site
662755006604	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
662755006605	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
662755006606	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
662755006607	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
662755006608	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
662755006609	DNA binding residues [nucleotide binding]
662755006610	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
662755006611	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
662755006612	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
662755006613	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
662755006614	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
662755006615	catalytic residues [active]
662755006616	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
662755006617	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
662755006618	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
662755006619	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
662755006620	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
662755006621	active site
662755006622	metal binding site [ion binding]; metal-binding site
662755006623	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
662755006624	ParB-like nuclease domain; Region: ParBc; pfam02195
662755006625	KorB domain; Region: KorB; pfam08535
662755006626	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
662755006627	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
662755006628	P-loop; other site
662755006629	Magnesium ion binding site [ion binding]; other site
662755006630	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
662755006631	Magnesium ion binding site [ion binding]; other site
662755006632	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
662755006633	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
662755006634	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
662755006635	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399