-- dump date   	20140619_052916
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
996634000001	putative DnaA box, TGTGGATAA
996634000002	putative DnaA box, CTTTCCACA
996634000003	putative DnaA box, TTCTTCACA
996634000004	putative DnaA box, TTATCCACA
996634000005	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
996634000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634000007	Walker A motif; other site
996634000008	ATP binding site [chemical binding]; other site
996634000009	Walker B motif; other site
996634000010	arginine finger; other site
996634000011	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
996634000012	DnaA box-binding interface [nucleotide binding]; other site
996634000013	DNA polymerase III subunit beta; Validated; Region: PRK07761
996634000014	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
996634000015	putative DNA binding surface [nucleotide binding]; other site
996634000016	dimer interface [polypeptide binding]; other site
996634000017	beta-clamp/clamp loader binding surface; other site
996634000018	beta-clamp/translesion DNA polymerase binding surface; other site
996634000019	recombination protein F; Reviewed; Region: recF; PRK00064
996634000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
996634000021	Walker A/P-loop; other site
996634000022	ATP binding site [chemical binding]; other site
996634000023	Q-loop/lid; other site
996634000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634000025	ABC transporter signature motif; other site
996634000026	Walker B; other site
996634000027	D-loop; other site
996634000028	H-loop/switch region; other site
996634000029	hypothetical protein; Provisional; Region: PRK00111
996634000030	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
996634000031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634000032	ATP binding site [chemical binding]; other site
996634000033	Mg2+ binding site [ion binding]; other site
996634000034	G-X-G motif; other site
996634000035	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
996634000036	anchoring element; other site
996634000037	dimer interface [polypeptide binding]; other site
996634000038	ATP binding site [chemical binding]; other site
996634000039	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
996634000040	active site
996634000041	putative metal-binding site [ion binding]; other site
996634000042	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
996634000043	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
996634000044	metal binding site [ion binding]; metal-binding site
996634000045	DNA gyrase subunit A; Validated; Region: PRK05560
996634000046	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
996634000047	CAP-like domain; other site
996634000048	active site
996634000049	primary dimer interface [polypeptide binding]; other site
996634000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996634000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996634000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996634000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996634000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996634000055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996634000056	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
996634000057	YwiC-like protein; Region: YwiC; pfam14256
996634000058	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
996634000059	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
996634000060	putative ligand binding site [chemical binding]; other site
996634000061	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996634000062	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
996634000063	TM-ABC transporter signature motif; other site
996634000064	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634000065	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
996634000066	Walker A/P-loop; other site
996634000067	ATP binding site [chemical binding]; other site
996634000068	Q-loop/lid; other site
996634000069	ABC transporter signature motif; other site
996634000070	Walker B; other site
996634000071	D-loop; other site
996634000072	H-loop/switch region; other site
996634000073	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
996634000074	active site
996634000075	Rhomboid family; Region: Rhomboid; pfam01694
996634000076	Zeta toxin; Region: Zeta_toxin; pfam06414
996634000077	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
996634000078	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
996634000079	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
996634000080	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996634000081	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
996634000082	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
996634000083	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
996634000084	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
996634000085	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
996634000086	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
996634000087	Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576
996634000088	putative active site [active]
996634000089	catalytic site [active]
996634000090	Mg binding site [ion binding]; other site
996634000091	catalytic loop [active]
996634000092	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634000093	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634000094	Walker A/P-loop; other site
996634000095	ATP binding site [chemical binding]; other site
996634000096	Q-loop/lid; other site
996634000097	ABC transporter signature motif; other site
996634000098	Walker B; other site
996634000099	D-loop; other site
996634000100	H-loop/switch region; other site
996634000101	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634000102	ABC-ATPase subunit  interface; other site
996634000103	dimer interface [polypeptide binding]; other site
996634000104	putative PBP binding regions; other site
996634000105	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634000106	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634000107	ABC-ATPase subunit  interface; other site
996634000108	dimer interface [polypeptide binding]; other site
996634000109	putative PBP binding regions; other site
996634000110	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
996634000111	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
996634000112	siderophore binding site; other site
996634000113	putative septation inhibitor protein; Reviewed; Region: PRK00159
996634000114	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
996634000115	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996634000116	active site
996634000117	ATP binding site [chemical binding]; other site
996634000118	substrate binding site [chemical binding]; other site
996634000119	activation loop (A-loop); other site
996634000120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
996634000121	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634000122	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634000123	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634000124	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634000125	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
996634000126	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996634000127	active site
996634000128	ATP binding site [chemical binding]; other site
996634000129	substrate binding site [chemical binding]; other site
996634000130	activation loop (A-loop); other site
996634000131	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
996634000132	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
996634000133	Protein phosphatase 2C; Region: PP2C; pfam00481
996634000134	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
996634000135	active site
996634000136	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
996634000137	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
996634000138	phosphopeptide binding site; other site
996634000139	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
996634000140	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
996634000141	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
996634000142	phosphopeptide binding site; other site
996634000143	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
996634000144	CAAX protease self-immunity; Region: Abi; pfam02517
996634000145	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
996634000146	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
996634000147	active site residue [active]
996634000148	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
996634000149	active site residue [active]
996634000150	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
996634000151	Predicted transcriptional regulators [Transcription]; Region: COG1695
996634000152	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
996634000153	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
996634000154	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634000155	intersubunit interface [polypeptide binding]; other site
996634000156	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634000157	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634000158	Walker A/P-loop; other site
996634000159	ATP binding site [chemical binding]; other site
996634000160	Q-loop/lid; other site
996634000161	ABC transporter signature motif; other site
996634000162	Walker B; other site
996634000163	D-loop; other site
996634000164	H-loop/switch region; other site
996634000165	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634000166	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634000167	ABC-ATPase subunit  interface; other site
996634000168	dimer interface [polypeptide binding]; other site
996634000169	putative PBP binding regions; other site
996634000170	MgtE intracellular N domain; Region: MgtE_N; cl15244
996634000171	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
996634000172	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
996634000173	Divalent cation transporter; Region: MgtE; cl00786
996634000174	trehalose synthase; Region: treS_nterm; TIGR02456
996634000175	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348
996634000176	active site
996634000177	catalytic site [active]
996634000178	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
996634000179	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
996634000180	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634000181	Walker A/P-loop; other site
996634000182	ATP binding site [chemical binding]; other site
996634000183	Q-loop/lid; other site
996634000184	ABC transporter signature motif; other site
996634000185	Walker B; other site
996634000186	D-loop; other site
996634000187	H-loop/switch region; other site
996634000188	SdpI/YhfL protein family; Region: SdpI; pfam13630
996634000189	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634000190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634000191	active site
996634000192	phosphorylation site [posttranslational modification]
996634000193	intermolecular recognition site; other site
996634000194	dimerization interface [polypeptide binding]; other site
996634000195	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634000196	DNA binding residues [nucleotide binding]
996634000197	dimerization interface [polypeptide binding]; other site
996634000198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996634000199	Histidine kinase; Region: HisKA_3; pfam07730
996634000200	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
996634000201	potential frameshift: common BLAST hit: gi|385806492|ref|YP_005842889.1| major facilitator superfamily protein
996634000202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634000203	Anti-sigma-K factor rskA; Region: RskA; pfam10099
996634000204	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
996634000205	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634000206	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634000207	DNA binding residues [nucleotide binding]
996634000208	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
996634000209	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
996634000210	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
996634000211	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996634000212	catalytic residues [active]
996634000213	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
996634000214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634000215	dimer interface [polypeptide binding]; other site
996634000216	conserved gate region; other site
996634000217	putative PBP binding loops; other site
996634000218	ABC-ATPase subunit interface; other site
996634000219	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
996634000220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634000221	Walker A/P-loop; other site
996634000222	ATP binding site [chemical binding]; other site
996634000223	Q-loop/lid; other site
996634000224	ABC transporter signature motif; other site
996634000225	Walker B; other site
996634000226	D-loop; other site
996634000227	H-loop/switch region; other site
996634000228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634000229	Coenzyme A binding pocket [chemical binding]; other site
996634000230	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
996634000231	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
996634000232	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
996634000233	putative metal binding site [ion binding]; other site
996634000234	biotin synthase; Validated; Region: PRK06256
996634000235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634000236	FeS/SAM binding site; other site
996634000237	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
996634000238	MepB protein; Region: MepB; cl01985
996634000239	AMP nucleosidase; Provisional; Region: PRK08292
996634000240	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
996634000241	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
996634000242	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
996634000243	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
996634000244	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
996634000245	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
996634000246	active site
996634000247	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
996634000248	active site
996634000249	catalytic site [active]
996634000250	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210
996634000251	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
996634000252	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
996634000253	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
996634000254	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
996634000255	active site
996634000256	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
996634000257	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
996634000258	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
996634000259	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634000260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634000261	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
996634000262	Replicase family; Region: Replicase; pfam03090
996634000263	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
996634000264	active site
996634000265	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
996634000266	LGFP repeat; Region: LGFP; pfam08310
996634000267	LGFP repeat; Region: LGFP; pfam08310
996634000268	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
996634000269	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
996634000270	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
996634000271	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
996634000272	CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764
996634000273	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996634000274	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
996634000275	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
996634000276	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
996634000277	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
996634000278	Lipase (class 2); Region: Lipase_2; pfam01674
996634000279	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
996634000280	dimer interface [polypeptide binding]; other site
996634000281	FMN binding site [chemical binding]; other site
996634000282	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
996634000283	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
996634000284	trimer interface [polypeptide binding]; other site
996634000285	putative metal binding site [ion binding]; other site
996634000286	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
996634000287	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
996634000288	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
996634000289	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
996634000290	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
996634000291	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634000292	Coenzyme A binding pocket [chemical binding]; other site
996634000293	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
996634000294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
996634000295	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
996634000296	MarR family; Region: MarR; pfam01047
996634000297	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
996634000298	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
996634000299	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
996634000300	hypothetical protein; Provisional; Region: PRK10621
996634000301	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996634000302	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
996634000303	active site
996634000304	phosphorylation site [posttranslational modification]
996634000305	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
996634000306	active site
996634000307	P-loop; other site
996634000308	phosphorylation site [posttranslational modification]
996634000309	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
996634000310	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634000311	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
996634000312	putative Mg++ binding site [ion binding]; other site
996634000313	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634000314	nucleotide binding region [chemical binding]; other site
996634000315	ATP-binding site [chemical binding]; other site
996634000316	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
996634000317	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
996634000318	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
996634000319	trimer interface [polypeptide binding]; other site
996634000320	active site
996634000321	substrate binding site [chemical binding]; other site
996634000322	CoA binding site [chemical binding]; other site
996634000323	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
996634000324	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
996634000325	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
996634000326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634000327	NAD(P) binding site [chemical binding]; other site
996634000328	active site
996634000329	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996634000330	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
996634000331	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634000332	RNA binding surface [nucleotide binding]; other site
996634000333	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
996634000334	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996634000335	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
996634000336	Domain of unknown function (DUF222); Region: DUF222; pfam02720
996634000337	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
996634000338	active site
996634000339	glycerol kinase; Provisional; Region: glpK; PRK00047
996634000340	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
996634000341	N- and C-terminal domain interface [polypeptide binding]; other site
996634000342	active site
996634000343	MgATP binding site [chemical binding]; other site
996634000344	catalytic site [active]
996634000345	metal binding site [ion binding]; metal-binding site
996634000346	putative homotetramer interface [polypeptide binding]; other site
996634000347	glycerol binding site [chemical binding]; other site
996634000348	homodimer interface [polypeptide binding]; other site
996634000349	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
996634000350	amphipathic channel; other site
996634000351	Asn-Pro-Ala signature motifs; other site
996634000352	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
996634000353	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
996634000354	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
996634000355	active site
996634000356	Zn binding site [ion binding]; other site
996634000357	Protease prsW family; Region: PrsW-protease; pfam13367
996634000358	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
996634000359	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
996634000360	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
996634000361	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
996634000362	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
996634000363	short chain dehydrogenase; Provisional; Region: PRK07904
996634000364	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
996634000365	NAD(P) binding site [chemical binding]; other site
996634000366	active site
996634000367	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
996634000368	FAD binding domain; Region: FAD_binding_4; pfam01565
996634000369	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
996634000370	Predicted membrane protein [Function unknown]; Region: COG2246
996634000371	GtrA-like protein; Region: GtrA; pfam04138
996634000372	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
996634000373	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996634000374	active site
996634000375	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634000376	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
996634000377	intersubunit interface [polypeptide binding]; other site
996634000378	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
996634000379	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
996634000380	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996634000381	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634000382	ABC-ATPase subunit  interface; other site
996634000383	dimer interface [polypeptide binding]; other site
996634000384	putative PBP binding regions; other site
996634000385	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996634000386	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634000387	ABC-ATPase subunit  interface; other site
996634000388	dimer interface [polypeptide binding]; other site
996634000389	putative PBP binding regions; other site
996634000390	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634000391	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
996634000392	intersubunit interface [polypeptide binding]; other site
996634000393	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
996634000394	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
996634000395	active site
996634000396	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
996634000397	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
996634000398	Walker A/P-loop; other site
996634000399	ATP binding site [chemical binding]; other site
996634000400	Q-loop/lid; other site
996634000401	ABC transporter signature motif; other site
996634000402	Walker B; other site
996634000403	D-loop; other site
996634000404	H-loop/switch region; other site
996634000405	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
996634000406	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
996634000407	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
996634000408	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
996634000409	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
996634000410	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
996634000411	NAD(P) binding site [chemical binding]; other site
996634000412	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
996634000413	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634000414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634000415	homodimer interface [polypeptide binding]; other site
996634000416	catalytic residue [active]
996634000417	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
996634000418	transmembrane helices; other site
996634000419	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
996634000420	CAT RNA binding domain; Region: CAT_RBD; smart01061
996634000421	PRD domain; Region: PRD; pfam00874
996634000422	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
996634000423	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
996634000424	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
996634000425	active site turn [active]
996634000426	phosphorylation site [posttranslational modification]
996634000427	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
996634000428	HPr interaction site; other site
996634000429	glycerol kinase (GK) interaction site [polypeptide binding]; other site
996634000430	active site
996634000431	phosphorylation site [posttranslational modification]
996634000432	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
996634000433	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996634000434	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
996634000435	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996634000436	phiCUL0102-I, diphtheria toxin-encoding prophage
996634000437	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
996634000438	active site
996634000439	catalytic residues [active]
996634000440	DNA binding site [nucleotide binding]
996634000441	Int/Topo IB signature motif; other site
996634000442	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996634000443	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996634000444	non-specific DNA binding site [nucleotide binding]; other site
996634000445	salt bridge; other site
996634000446	sequence-specific DNA binding site [nucleotide binding]; other site
996634000447	Domain of unknown function (DUF955); Region: DUF955; cl01076
996634000448	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
996634000449	Domain of unknown function (DUF955); Region: DUF955; pfam06114
996634000450	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996634000451	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996634000452	sequence-specific DNA binding site [nucleotide binding]; other site
996634000453	salt bridge; other site
996634000454	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
996634000455	sequence-specific DNA binding site [nucleotide binding]; other site
996634000456	salt bridge; other site
996634000457	Helix-turn-helix domain; Region: HTH_17; pfam12728
996634000458	Prophage antirepressor [Transcription]; Region: COG3617
996634000459	BRO family, N-terminal domain; Region: Bro-N; smart01040
996634000460	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
996634000461	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
996634000462	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
996634000463	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
996634000464	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
996634000465	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
996634000466	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
996634000467	trimer interface [polypeptide binding]; other site
996634000468	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
996634000469	amidase catalytic site [active]
996634000470	Zn binding residues [ion binding]; other site
996634000471	substrate binding site [chemical binding]; other site
996634000472	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283
996634000473	nad+ binding pocket [chemical binding]; other site
996634000474	Diphtheria toxin, T domain; Region: Diphtheria_T; pfam02764
996634000475	Diphtheria toxin, R domain; Region: Diphtheria_R; pfam01324
996634000476	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
996634000477	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996634000478	DNA-binding site [nucleotide binding]; DNA binding site
996634000479	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634000480	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634000481	homodimer interface [polypeptide binding]; other site
996634000482	catalytic residue [active]
996634000483	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
996634000484	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
996634000485	active site
996634000486	multimer interface [polypeptide binding]; other site
996634000487	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
996634000488	predicted active site [active]
996634000489	catalytic triad [active]
996634000490	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
996634000491	prephenate dehydrogenase; Validated; Region: PRK06545
996634000492	prephenate dehydrogenase; Validated; Region: PRK08507
996634000493	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
996634000494	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
996634000495	nucleoside/Zn binding site; other site
996634000496	dimer interface [polypeptide binding]; other site
996634000497	catalytic motif [active]
996634000498	MMPL family; Region: MMPL; pfam03176
996634000499	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
996634000500	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
996634000501	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
996634000502	active site
996634000503	HIGH motif; other site
996634000504	nucleotide binding site [chemical binding]; other site
996634000505	active site
996634000506	KMSKS motif; other site
996634000507	fructuronate transporter; Provisional; Region: PRK10034; cl15264
996634000508	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
996634000509	Shikimate kinase; Region: SKI; pfam01202
996634000510	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
996634000511	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
996634000512	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
996634000513	putative NAD(P) binding site [chemical binding]; other site
996634000514	catalytic Zn binding site [ion binding]; other site
996634000515	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
996634000516	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
996634000517	NADP binding site [chemical binding]; other site
996634000518	homodimer interface [polypeptide binding]; other site
996634000519	active site
996634000520	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
996634000521	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634000522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634000523	homodimer interface [polypeptide binding]; other site
996634000524	catalytic residue [active]
996634000525	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
996634000526	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
996634000527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634000528	Walker A motif; other site
996634000529	ATP binding site [chemical binding]; other site
996634000530	Walker B motif; other site
996634000531	arginine finger; other site
996634000532	hypothetical protein; Validated; Region: PRK00153
996634000533	recombination protein RecR; Reviewed; Region: recR; PRK00076
996634000534	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
996634000535	RecR protein; Region: RecR; pfam02132
996634000536	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
996634000537	putative active site [active]
996634000538	putative metal-binding site [ion binding]; other site
996634000539	tetramer interface [polypeptide binding]; other site
996634000540	putative transporter; Provisional; Region: PRK09821
996634000541	GntP family permease; Region: GntP_permease; pfam02447
996634000542	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
996634000543	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996634000544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
996634000545	Transcriptional regulators [Transcription]; Region: FadR; COG2186
996634000546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996634000547	DNA-binding site [nucleotide binding]; DNA binding site
996634000548	FCD domain; Region: FCD; pfam07729
996634000549	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
996634000550	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
996634000551	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
996634000552	catalytic triad [active]
996634000553	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
996634000554	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996634000555	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
996634000556	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
996634000557	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
996634000558	active site
996634000559	catalytic site [active]
996634000560	substrate binding site [chemical binding]; other site
996634000561	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
996634000562	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
996634000563	dimer interface [polypeptide binding]; other site
996634000564	FMN binding site [chemical binding]; other site
996634000565	NADPH bind site [chemical binding]; other site
996634000566	2-isopropylmalate synthase; Validated; Region: PRK03739
996634000567	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
996634000568	active site
996634000569	catalytic residues [active]
996634000570	metal binding site [ion binding]; metal-binding site
996634000571	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
996634000572	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
996634000573	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634000574	DNA binding residues [nucleotide binding]
996634000575	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
996634000576	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
996634000577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634000578	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996634000579	putative substrate translocation pore; other site
996634000580	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
996634000581	intersubunit interface [polypeptide binding]; other site
996634000582	active site
996634000583	catalytic residue [active]
996634000584	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
996634000585	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
996634000586	active site
996634000587	substrate binding site [chemical binding]; other site
996634000588	metal binding site [ion binding]; metal-binding site
996634000589	TQXA domain; Region: TQXA_dom; TIGR03934
996634000590	Cna protein B-type domain; Region: Cna_B; pfam05738
996634000591	Cna protein B-type domain; Region: Cna_B; pfam05738
996634000592	Cna protein B-type domain; Region: Cna_B; pfam05738
996634000593	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634000594	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996634000595	Walker A/P-loop; other site
996634000596	ATP binding site [chemical binding]; other site
996634000597	Q-loop/lid; other site
996634000598	ABC transporter signature motif; other site
996634000599	Walker B; other site
996634000600	D-loop; other site
996634000601	H-loop/switch region; other site
996634000602	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
996634000603	aspartate kinase; Reviewed; Region: PRK06635
996634000604	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
996634000605	putative nucleotide binding site [chemical binding]; other site
996634000606	putative catalytic residues [active]
996634000607	putative Mg ion binding site [ion binding]; other site
996634000608	putative aspartate binding site [chemical binding]; other site
996634000609	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
996634000610	putative allosteric regulatory site; other site
996634000611	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
996634000612	putative allosteric regulatory residue; other site
996634000613	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
996634000614	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
996634000615	RNA polymerase sigma factor; Provisional; Region: PRK12535
996634000616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634000617	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634000618	DNA binding residues [nucleotide binding]
996634000619	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
996634000620	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
996634000621	heme binding pocket [chemical binding]; other site
996634000622	LGFP repeat; Region: LGFP; pfam08310
996634000623	LGFP repeat; Region: LGFP; pfam08310
996634000624	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
996634000625	potential frameshift: common BLAST hit: gi|337289842|ref|YP_004628863.1| laminin subunit beta-2
996634000626	tail fiber protein; Region: PHA00430
996634000627	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
996634000628	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
996634000629	Walker A/P-loop; other site
996634000630	ATP binding site [chemical binding]; other site
996634000631	Q-loop/lid; other site
996634000632	ABC transporter signature motif; other site
996634000633	Walker B; other site
996634000634	D-loop; other site
996634000635	H-loop/switch region; other site
996634000636	TOBE domain; Region: TOBE_2; pfam08402
996634000637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634000638	dimer interface [polypeptide binding]; other site
996634000639	conserved gate region; other site
996634000640	ABC-ATPase subunit interface; other site
996634000641	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
996634000642	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
996634000643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634000644	putative substrate translocation pore; other site
996634000645	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996634000646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634000647	active site
996634000648	phosphorylation site [posttranslational modification]
996634000649	intermolecular recognition site; other site
996634000650	dimerization interface [polypeptide binding]; other site
996634000651	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996634000652	DNA binding site [nucleotide binding]
996634000653	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996634000654	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996634000655	dimer interface [polypeptide binding]; other site
996634000656	phosphorylation site [posttranslational modification]
996634000657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634000658	ATP binding site [chemical binding]; other site
996634000659	Mg2+ binding site [ion binding]; other site
996634000660	G-X-G motif; other site
996634000661	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
996634000662	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
996634000663	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
996634000664	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
996634000665	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996634000666	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
996634000667	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
996634000668	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996634000669	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
996634000670	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
996634000671	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996634000672	Predicted membrane protein [Function unknown]; Region: COG1511
996634000673	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
996634000674	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
996634000675	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
996634000676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634000677	Walker A/P-loop; other site
996634000678	ATP binding site [chemical binding]; other site
996634000679	Q-loop/lid; other site
996634000680	ABC transporter signature motif; other site
996634000681	Walker B; other site
996634000682	D-loop; other site
996634000683	H-loop/switch region; other site
996634000684	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
996634000685	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
996634000686	putative active site [active]
996634000687	putative metal binding site [ion binding]; other site
996634000688	Yqey-like protein; Region: YqeY; pfam09424
996634000689	Transglycosylase; Region: Transgly; pfam00912
996634000690	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
996634000691	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
996634000692	PASTA domain; Region: PASTA; pfam03793
996634000693	Transcription factor WhiB; Region: Whib; pfam02467
996634000694	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
996634000695	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
996634000696	homotrimer interaction site [polypeptide binding]; other site
996634000697	putative active site [active]
996634000698	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
996634000699	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
996634000700	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996634000701	ligand binding site [chemical binding]; other site
996634000702	flexible hinge region; other site
996634000703	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
996634000704	putative switch regulator; other site
996634000705	non-specific DNA interactions [nucleotide binding]; other site
996634000706	DNA binding site [nucleotide binding]
996634000707	sequence specific DNA binding site [nucleotide binding]; other site
996634000708	putative cAMP binding site [chemical binding]; other site
996634000709	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
996634000710	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
996634000711	minor groove reading motif; other site
996634000712	helix-hairpin-helix signature motif; other site
996634000713	substrate binding pocket [chemical binding]; other site
996634000714	active site
996634000715	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
996634000716	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
996634000717	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996634000718	catalytic residues [active]
996634000719	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
996634000720	putative active site [active]
996634000721	putative CoA binding site [chemical binding]; other site
996634000722	nudix motif; other site
996634000723	metal binding site [ion binding]; metal-binding site
996634000724	Colicin V production protein; Region: Colicin_V; pfam02674
996634000725	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
996634000726	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
996634000727	active site
996634000728	substrate binding sites [chemical binding]; other site
996634000729	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
996634000730	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
996634000731	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
996634000732	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
996634000733	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634000734	motif II; other site
996634000735	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
996634000736	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
996634000737	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
996634000738	ATP binding site [chemical binding]; other site
996634000739	Walker A motif; other site
996634000740	hexamer interface [polypeptide binding]; other site
996634000741	Walker B motif; other site
996634000742	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
996634000743	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
996634000744	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
996634000745	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
996634000746	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
996634000747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634000748	ATP binding site [chemical binding]; other site
996634000749	putative Mg++ binding site [ion binding]; other site
996634000750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634000751	nucleotide binding region [chemical binding]; other site
996634000752	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
996634000753	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996634000754	DNA-binding site [nucleotide binding]; DNA binding site
996634000755	RNA-binding motif; other site
996634000756	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
996634000757	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
996634000758	active site
996634000759	interdomain interaction site; other site
996634000760	putative metal-binding site [ion binding]; other site
996634000761	nucleotide binding site [chemical binding]; other site
996634000762	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
996634000763	domain I; other site
996634000764	DNA binding groove [nucleotide binding]
996634000765	phosphate binding site [ion binding]; other site
996634000766	domain II; other site
996634000767	domain III; other site
996634000768	nucleotide binding site [chemical binding]; other site
996634000769	catalytic site [active]
996634000770	domain IV; other site
996634000771	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
996634000772	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
996634000773	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
996634000774	Predicted membrane protein [Function unknown]; Region: COG1297
996634000775	putative oligopeptide transporter, OPT family; Region: TIGR00733
996634000776	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996634000777	dimerization interface [polypeptide binding]; other site
996634000778	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
996634000779	cyclase homology domain; Region: CHD; cd07302
996634000780	nucleotidyl binding site; other site
996634000781	dimer interface [polypeptide binding]; other site
996634000782	metal binding site [ion binding]; metal-binding site
996634000783	DNA polymerase III subunit delta'; Validated; Region: PRK07940
996634000784	DNA polymerase III subunit delta'; Validated; Region: PRK08485
996634000785	acyl-CoA synthetase; Validated; Region: PRK07788
996634000786	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996634000787	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996634000788	acyl-activating enzyme (AAE) consensus motif; other site
996634000789	acyl-activating enzyme (AAE) consensus motif; other site
996634000790	AMP binding site [chemical binding]; other site
996634000791	active site
996634000792	CoA binding site [chemical binding]; other site
996634000793	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
996634000794	active site
996634000795	catalytic triad [active]
996634000796	oxyanion hole [active]
996634000797	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
996634000798	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
996634000799	substrate binding site; other site
996634000800	tetramer interface; other site
996634000801	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
996634000802	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
996634000803	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
996634000804	NADP binding site [chemical binding]; other site
996634000805	active site
996634000806	putative substrate binding site [chemical binding]; other site
996634000807	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
996634000808	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
996634000809	NAD binding site [chemical binding]; other site
996634000810	substrate binding site [chemical binding]; other site
996634000811	homodimer interface [polypeptide binding]; other site
996634000812	active site
996634000813	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
996634000814	Zn binding site [ion binding]; other site
996634000815	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
996634000816	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996634000817	Putative esterase; Region: Esterase; pfam00756
996634000818	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
996634000819	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
996634000820	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996634000821	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996634000822	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996634000823	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996634000824	non-specific DNA binding site [nucleotide binding]; other site
996634000825	salt bridge; other site
996634000826	sequence-specific DNA binding site [nucleotide binding]; other site
996634000827	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
996634000828	Domain of unknown function (DUF955); Region: DUF955; pfam06114
996634000829	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
996634000830	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
996634000831	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
996634000832	putative Iron-sulfur protein interface [polypeptide binding]; other site
996634000833	proximal heme binding site [chemical binding]; other site
996634000834	distal heme binding site [chemical binding]; other site
996634000835	putative dimer interface [polypeptide binding]; other site
996634000836	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
996634000837	L-aspartate oxidase; Provisional; Region: PRK06175
996634000838	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
996634000839	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
996634000840	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
996634000841	Predicted membrane protein [Function unknown]; Region: COG2733
996634000842	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
996634000843	Class I aldolases; Region: Aldolase_Class_I; cl17187
996634000844	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
996634000845	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
996634000846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634000847	FeS/SAM binding site; other site
996634000848	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
996634000849	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
996634000850	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
996634000851	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
996634000852	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
996634000853	FAD binding domain; Region: FAD_binding_4; pfam01565
996634000854	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
996634000855	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
996634000856	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
996634000857	acyl-activating enzyme (AAE) consensus motif; other site
996634000858	putative AMP binding site [chemical binding]; other site
996634000859	putative active site [active]
996634000860	putative CoA binding site [chemical binding]; other site
996634000861	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
996634000862	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
996634000863	putative ADP-binding pocket [chemical binding]; other site
996634000864	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634000865	catalytic core [active]
996634000866	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634000867	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996634000868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996634000869	dimer interface [polypeptide binding]; other site
996634000870	phosphorylation site [posttranslational modification]
996634000871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634000872	ATP binding site [chemical binding]; other site
996634000873	Mg2+ binding site [ion binding]; other site
996634000874	G-X-G motif; other site
996634000875	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996634000876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634000877	active site
996634000878	phosphorylation site [posttranslational modification]
996634000879	intermolecular recognition site; other site
996634000880	dimerization interface [polypeptide binding]; other site
996634000881	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996634000882	DNA binding site [nucleotide binding]
996634000883	exopolyphosphatase; Region: exo_poly_only; TIGR03706
996634000884	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
996634000885	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
996634000886	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
996634000887	DNA binding domain, excisionase family; Region: excise; TIGR01764
996634000888	Thioredoxin; Region: Thioredoxin_4; pfam13462
996634000889	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
996634000890	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
996634000891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634000892	motif II; other site
996634000893	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
996634000894	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
996634000895	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
996634000896	tRNA; other site
996634000897	putative tRNA binding site [nucleotide binding]; other site
996634000898	putative NADP binding site [chemical binding]; other site
996634000899	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
996634000900	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
996634000901	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
996634000902	domain interfaces; other site
996634000903	active site
996634000904	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
996634000905	active site
996634000906	homodimer interface [polypeptide binding]; other site
996634000907	SAM binding site [chemical binding]; other site
996634000908	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
996634000909	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
996634000910	active site
996634000911	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
996634000912	dimer interface [polypeptide binding]; other site
996634000913	active site
996634000914	Schiff base residues; other site
996634000915	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996634000916	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
996634000917	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
996634000918	substrate binding site [chemical binding]; other site
996634000919	active site
996634000920	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
996634000921	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
996634000922	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996634000923	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
996634000924	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996634000925	inhibitor-cofactor binding pocket; inhibition site
996634000926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634000927	catalytic residue [active]
996634000928	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634000929	catalytic core [active]
996634000930	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
996634000931	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996634000932	catalytic residues [active]
996634000933	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
996634000934	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
996634000935	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
996634000936	ResB-like family; Region: ResB; pfam05140
996634000937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
996634000938	Methyltransferase domain; Region: Methyltransf_31; pfam13847
996634000939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634000940	S-adenosylmethionine binding site [chemical binding]; other site
996634000941	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
996634000942	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996634000943	dimerization interface [polypeptide binding]; other site
996634000944	putative DNA binding site [nucleotide binding]; other site
996634000945	putative Zn2+ binding site [ion binding]; other site
996634000946	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
996634000947	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
996634000948	UbiA prenyltransferase family; Region: UbiA; pfam01040
996634000949	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
996634000950	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996634000951	acyl-activating enzyme (AAE) consensus motif; other site
996634000952	AMP binding site [chemical binding]; other site
996634000953	active site
996634000954	CoA binding site [chemical binding]; other site
996634000955	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
996634000956	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996634000957	substrate binding site [chemical binding]; other site
996634000958	oxyanion hole (OAH) forming residues; other site
996634000959	trimer interface [polypeptide binding]; other site
996634000960	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
996634000961	oligomer interface [polypeptide binding]; other site
996634000962	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
996634000963	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
996634000964	O-succinylbenzoate synthase; Provisional; Region: PRK02901
996634000965	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
996634000966	active site
996634000967	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
996634000968	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
996634000969	dimer interface [polypeptide binding]; other site
996634000970	tetramer interface [polypeptide binding]; other site
996634000971	PYR/PP interface [polypeptide binding]; other site
996634000972	TPP binding site [chemical binding]; other site
996634000973	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
996634000974	TPP-binding site; other site
996634000975	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
996634000976	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
996634000977	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
996634000978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634000979	S-adenosylmethionine binding site [chemical binding]; other site
996634000980	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
996634000981	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
996634000982	NAD(P) binding site [chemical binding]; other site
996634000983	LDH/MDH dimer interface [polypeptide binding]; other site
996634000984	substrate binding site [chemical binding]; other site
996634000985	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
996634000986	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996634000987	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
996634000988	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
996634000989	substrate binding pocket [chemical binding]; other site
996634000990	chain length determination region; other site
996634000991	substrate-Mg2+ binding site; other site
996634000992	catalytic residues [active]
996634000993	aspartate-rich region 1; other site
996634000994	active site lid residues [active]
996634000995	aspartate-rich region 2; other site
996634000996	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
996634000997	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
996634000998	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
996634000999	putative homodimer interface [polypeptide binding]; other site
996634001000	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
996634001001	heterodimer interface [polypeptide binding]; other site
996634001002	homodimer interface [polypeptide binding]; other site
996634001003	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
996634001004	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
996634001005	23S rRNA interface [nucleotide binding]; other site
996634001006	L7/L12 interface [polypeptide binding]; other site
996634001007	putative thiostrepton binding site; other site
996634001008	L25 interface [polypeptide binding]; other site
996634001009	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
996634001010	mRNA/rRNA interface [nucleotide binding]; other site
996634001011	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
996634001012	trimer interface [polypeptide binding]; other site
996634001013	active site
996634001014	G bulge; other site
996634001015	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
996634001016	trimer interface [polypeptide binding]; other site
996634001017	active site
996634001018	G bulge; other site
996634001019	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
996634001020	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
996634001021	FMN binding site [chemical binding]; other site
996634001022	active site
996634001023	substrate binding site [chemical binding]; other site
996634001024	catalytic residue [active]
996634001025	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
996634001026	23S rRNA interface [nucleotide binding]; other site
996634001027	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
996634001028	50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157
996634001029	L11 interface [polypeptide binding]; other site
996634001030	putative EF-Tu interaction site [polypeptide binding]; other site
996634001031	putative EF-G interaction site [polypeptide binding]; other site
996634001032	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
996634001033	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634001034	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
996634001035	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634001036	intersubunit interface [polypeptide binding]; other site
996634001037	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634001038	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634001039	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
996634001040	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634001041	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
996634001042	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
996634001043	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
996634001044	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996634001045	putative PBP binding regions; other site
996634001046	ABC-ATPase subunit  interface; other site
996634001047	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
996634001048	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
996634001049	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
996634001050	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
996634001051	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
996634001052	RPB1 interaction site [polypeptide binding]; other site
996634001053	RPB10 interaction site [polypeptide binding]; other site
996634001054	RPB11 interaction site [polypeptide binding]; other site
996634001055	RPB3 interaction site [polypeptide binding]; other site
996634001056	RPB12 interaction site [polypeptide binding]; other site
996634001057	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
996634001058	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
996634001059	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
996634001060	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
996634001061	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
996634001062	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
996634001063	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
996634001064	G-loop; other site
996634001065	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
996634001066	DNA binding site [nucleotide binding]
996634001067	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
996634001068	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
996634001069	TQXA domain; Region: TQXA_dom; TIGR03934
996634001070	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
996634001071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996634001072	Histidine kinase; Region: HisKA_3; pfam07730
996634001073	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
996634001074	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634001075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634001076	active site
996634001077	phosphorylation site [posttranslational modification]
996634001078	intermolecular recognition site; other site
996634001079	dimerization interface [polypeptide binding]; other site
996634001080	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634001081	DNA binding residues [nucleotide binding]
996634001082	dimerization interface [polypeptide binding]; other site
996634001083	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634001084	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
996634001085	Walker A/P-loop; other site
996634001086	ATP binding site [chemical binding]; other site
996634001087	Q-loop/lid; other site
996634001088	ABC transporter signature motif; other site
996634001089	Walker B; other site
996634001090	D-loop; other site
996634001091	H-loop/switch region; other site
996634001092	TIGR03943 family protein; Region: TIGR03943
996634001093	Predicted permease; Region: DUF318; cl17795
996634001094	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
996634001095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634001096	FeS/SAM binding site; other site
996634001097	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
996634001098	Class III ribonucleotide reductase; Region: RNR_III; cd01675
996634001099	effector binding site; other site
996634001100	active site
996634001101	Zn binding site [ion binding]; other site
996634001102	glycine loop; other site
996634001103	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
996634001104	S17 interaction site [polypeptide binding]; other site
996634001105	S8 interaction site; other site
996634001106	16S rRNA interaction site [nucleotide binding]; other site
996634001107	streptomycin interaction site [chemical binding]; other site
996634001108	23S rRNA interaction site [nucleotide binding]; other site
996634001109	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
996634001110	30S ribosomal protein S7; Validated; Region: PRK05302
996634001111	elongation factor G; Reviewed; Region: PRK00007
996634001112	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
996634001113	G1 box; other site
996634001114	putative GEF interaction site [polypeptide binding]; other site
996634001115	GTP/Mg2+ binding site [chemical binding]; other site
996634001116	Switch I region; other site
996634001117	G2 box; other site
996634001118	G3 box; other site
996634001119	Switch II region; other site
996634001120	G4 box; other site
996634001121	G5 box; other site
996634001122	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
996634001123	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
996634001124	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
996634001125	elongation factor Tu; Reviewed; Region: PRK00049
996634001126	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
996634001127	G1 box; other site
996634001128	GEF interaction site [polypeptide binding]; other site
996634001129	GTP/Mg2+ binding site [chemical binding]; other site
996634001130	Switch I region; other site
996634001131	G2 box; other site
996634001132	G3 box; other site
996634001133	Switch II region; other site
996634001134	G4 box; other site
996634001135	G5 box; other site
996634001136	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
996634001137	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
996634001138	Antibiotic Binding Site [chemical binding]; other site
996634001139	Predicted membrane protein [Function unknown]; Region: COG2323
996634001140	Asp23 family; Region: Asp23; cl00574
996634001141	Asp23 family; Region: Asp23; cl00574
996634001142	Asp23 family; Region: Asp23; pfam03780
996634001143	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
996634001144	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
996634001145	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
996634001146	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
996634001147	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
996634001148	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
996634001149	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
996634001150	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
996634001151	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
996634001152	putative translocon binding site; other site
996634001153	protein-rRNA interface [nucleotide binding]; other site
996634001154	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
996634001155	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
996634001156	G-X-X-G motif; other site
996634001157	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
996634001158	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
996634001159	23S rRNA interface [nucleotide binding]; other site
996634001160	5S rRNA interface [nucleotide binding]; other site
996634001161	putative antibiotic binding site [chemical binding]; other site
996634001162	L25 interface [polypeptide binding]; other site
996634001163	L27 interface [polypeptide binding]; other site
996634001164	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
996634001165	putative translocon interaction site; other site
996634001166	23S rRNA interface [nucleotide binding]; other site
996634001167	signal recognition particle (SRP54) interaction site; other site
996634001168	L23 interface [polypeptide binding]; other site
996634001169	trigger factor interaction site; other site
996634001170	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
996634001171	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
996634001172	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
996634001173	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
996634001174	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634001175	Walker A/P-loop; other site
996634001176	ATP binding site [chemical binding]; other site
996634001177	Q-loop/lid; other site
996634001178	ABC transporter signature motif; other site
996634001179	Walker B; other site
996634001180	D-loop; other site
996634001181	H-loop/switch region; other site
996634001182	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634001183	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634001184	Walker A/P-loop; other site
996634001185	ATP binding site [chemical binding]; other site
996634001186	Q-loop/lid; other site
996634001187	ABC transporter signature motif; other site
996634001188	Walker B; other site
996634001189	D-loop; other site
996634001190	H-loop/switch region; other site
996634001191	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634001192	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634001193	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
996634001194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001195	dimer interface [polypeptide binding]; other site
996634001196	conserved gate region; other site
996634001197	putative PBP binding loops; other site
996634001198	ABC-ATPase subunit interface; other site
996634001199	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634001200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001201	putative PBP binding loops; other site
996634001202	dimer interface [polypeptide binding]; other site
996634001203	ABC-ATPase subunit interface; other site
996634001204	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
996634001205	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
996634001206	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
996634001207	RNA binding site [nucleotide binding]; other site
996634001208	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
996634001209	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
996634001210	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
996634001211	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
996634001212	serine transporter; Region: stp; TIGR00814
996634001213	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
996634001214	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
996634001215	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
996634001216	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
996634001217	active site
996634001218	homotetramer interface [polypeptide binding]; other site
996634001219	homodimer interface [polypeptide binding]; other site
996634001220	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
996634001221	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
996634001222	active site
996634001223	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
996634001224	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
996634001225	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
996634001226	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
996634001227	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
996634001228	5S rRNA interface [nucleotide binding]; other site
996634001229	23S rRNA interface [nucleotide binding]; other site
996634001230	L5 interface [polypeptide binding]; other site
996634001231	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
996634001232	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
996634001233	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
996634001234	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
996634001235	23S rRNA binding site [nucleotide binding]; other site
996634001236	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
996634001237	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
996634001238	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
996634001239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001240	dimer interface [polypeptide binding]; other site
996634001241	conserved gate region; other site
996634001242	putative PBP binding loops; other site
996634001243	ABC-ATPase subunit interface; other site
996634001244	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
996634001245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001246	dimer interface [polypeptide binding]; other site
996634001247	conserved gate region; other site
996634001248	putative PBP binding loops; other site
996634001249	ABC-ATPase subunit interface; other site
996634001250	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
996634001251	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
996634001252	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
996634001253	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
996634001254	Walker A/P-loop; other site
996634001255	ATP binding site [chemical binding]; other site
996634001256	Q-loop/lid; other site
996634001257	ABC transporter signature motif; other site
996634001258	Walker B; other site
996634001259	D-loop; other site
996634001260	H-loop/switch region; other site
996634001261	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
996634001262	SecY translocase; Region: SecY; pfam00344
996634001263	adenylate kinase; Reviewed; Region: adk; PRK00279
996634001264	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
996634001265	AMP-binding site [chemical binding]; other site
996634001266	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
996634001267	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
996634001268	active site
996634001269	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
996634001270	catalytic site [active]
996634001271	Asp-box motif; other site
996634001272	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
996634001273	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
996634001274	rRNA binding site [nucleotide binding]; other site
996634001275	predicted 30S ribosome binding site; other site
996634001276	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
996634001277	30S ribosomal protein S13; Region: bact_S13; TIGR03631
996634001278	30S ribosomal protein S11; Validated; Region: PRK05309
996634001279	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
996634001280	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
996634001281	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634001282	RNA binding surface [nucleotide binding]; other site
996634001283	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
996634001284	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
996634001285	alphaNTD - beta interaction site [polypeptide binding]; other site
996634001286	alphaNTD homodimer interface [polypeptide binding]; other site
996634001287	alphaNTD - beta' interaction site [polypeptide binding]; other site
996634001288	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
996634001289	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
996634001290	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
996634001291	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
996634001292	dimerization interface 3.5A [polypeptide binding]; other site
996634001293	active site
996634001294	Protein of unknown function (DUF690); Region: DUF690; cl04939
996634001295	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
996634001296	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
996634001297	active site
996634001298	catalytic residues [active]
996634001299	potential frameshift: common BLAST hit: gi|38233164|ref|NP_938931.1| putative surface-anchored membrane protein
996634001300	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
996634001301	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
996634001302	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
996634001303	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
996634001304	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
996634001305	phiCUL0102-II
996634001306	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996634001307	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
996634001308	DNA binding site [nucleotide binding]
996634001309	Int/Topo IB signature motif; other site
996634001310	active site
996634001311	catalytic residues [active]
996634001312	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996634001313	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996634001314	non-specific DNA binding site [nucleotide binding]; other site
996634001315	salt bridge; other site
996634001316	sequence-specific DNA binding site [nucleotide binding]; other site
996634001317	Helix-turn-helix domain; Region: HTH_17; pfam12728
996634001318	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
996634001319	active site
996634001320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996634001321	DNA-binding site [nucleotide binding]; DNA binding site
996634001322	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
996634001323	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
996634001324	dimer interface [polypeptide binding]; other site
996634001325	ssDNA binding site [nucleotide binding]; other site
996634001326	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996634001327	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
996634001328	trimer interface [polypeptide binding]; other site
996634001329	active site
996634001330	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
996634001331	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
996634001332	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
996634001333	ParB-like nuclease domain; Region: ParB; smart00470
996634001334	Methyltransferase domain; Region: Methyltransf_26; pfam13659
996634001335	ParB-like nuclease domain; Region: ParB; smart00470
996634001336	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
996634001337	Phage terminase large subunit; Region: Terminase_3; cl12054
996634001338	Terminase-like family; Region: Terminase_6; pfam03237
996634001339	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
996634001340	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
996634001341	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
996634001342	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
996634001343	NlpC/P60 family; Region: NLPC_P60; cl17555
996634001344	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996634001345	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
996634001346	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497
996634001347	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
996634001348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
996634001349	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
996634001350	23S rRNA interface [nucleotide binding]; other site
996634001351	L3 interface [polypeptide binding]; other site
996634001352	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
996634001353	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
996634001354	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
996634001355	active site
996634001356	substrate binding site [chemical binding]; other site
996634001357	metal binding site [ion binding]; metal-binding site
996634001358	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
996634001359	alanine racemase; Reviewed; Region: alr; PRK00053
996634001360	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
996634001361	active site
996634001362	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996634001363	dimer interface [polypeptide binding]; other site
996634001364	substrate binding site [chemical binding]; other site
996634001365	catalytic residues [active]
996634001366	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
996634001367	Predicted permease [General function prediction only]; Region: COG2985
996634001368	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
996634001369	TrkA-C domain; Region: TrkA_C; pfam02080
996634001370	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
996634001371	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
996634001372	Glycoprotease family; Region: Peptidase_M22; pfam00814
996634001373	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
996634001374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634001375	Coenzyme A binding pocket [chemical binding]; other site
996634001376	UGMP family protein; Validated; Region: PRK09604
996634001377	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
996634001378	oligomerisation interface [polypeptide binding]; other site
996634001379	mobile loop; other site
996634001380	roof hairpin; other site
996634001381	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
996634001382	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
996634001383	ring oligomerisation interface [polypeptide binding]; other site
996634001384	ATP/Mg binding site [chemical binding]; other site
996634001385	stacking interactions; other site
996634001386	hinge regions; other site
996634001387	Transcription factor WhiB; Region: Whib; pfam02467
996634001388	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
996634001389	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634001390	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634001391	DNA binding residues [nucleotide binding]
996634001392	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
996634001393	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
996634001394	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
996634001395	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
996634001396	active site
996634001397	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
996634001398	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
996634001399	phosphate binding site [ion binding]; other site
996634001400	Amino acid permease; Region: AA_permease_2; pfam13520
996634001401	GMP synthase; Reviewed; Region: guaA; PRK00074
996634001402	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
996634001403	AMP/PPi binding site [chemical binding]; other site
996634001404	candidate oxyanion hole; other site
996634001405	catalytic triad [active]
996634001406	potential glutamine specificity residues [chemical binding]; other site
996634001407	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
996634001408	ATP Binding subdomain [chemical binding]; other site
996634001409	Ligand Binding sites [chemical binding]; other site
996634001410	Dimerization subdomain; other site
996634001411	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
996634001412	PspC domain; Region: PspC; pfam04024
996634001413	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996634001414	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
996634001415	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634001416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634001417	active site
996634001418	phosphorylation site [posttranslational modification]
996634001419	intermolecular recognition site; other site
996634001420	dimerization interface [polypeptide binding]; other site
996634001421	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634001422	dimerization interface [polypeptide binding]; other site
996634001423	DNA binding residues [nucleotide binding]
996634001424	AMIN domain; Region: AMIN; pfam11741
996634001425	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
996634001426	putative dimer interface [polypeptide binding]; other site
996634001427	putative [2Fe-2S] cluster binding site [ion binding]; other site
996634001428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001429	dimer interface [polypeptide binding]; other site
996634001430	conserved gate region; other site
996634001431	ABC-ATPase subunit interface; other site
996634001432	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
996634001433	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
996634001434	Walker A/P-loop; other site
996634001435	ATP binding site [chemical binding]; other site
996634001436	Q-loop/lid; other site
996634001437	ABC transporter signature motif; other site
996634001438	Walker B; other site
996634001439	D-loop; other site
996634001440	H-loop/switch region; other site
996634001441	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
996634001442	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
996634001443	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
996634001444	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
996634001445	Uncharacterized conserved protein [Function unknown]; Region: COG3402
996634001446	Predicted membrane protein [Function unknown]; Region: COG3428
996634001447	Bacterial PH domain; Region: DUF304; pfam03703
996634001448	Bacterial PH domain; Region: DUF304; cl01348
996634001449	Bacterial PH domain; Region: DUF304; pfam03703
996634001450	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634001451	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
996634001452	intersubunit interface [polypeptide binding]; other site
996634001453	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
996634001454	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
996634001455	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996634001456	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634001457	ABC-ATPase subunit  interface; other site
996634001458	dimer interface [polypeptide binding]; other site
996634001459	putative PBP binding regions; other site
996634001460	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996634001461	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
996634001462	ABC-ATPase subunit  interface; other site
996634001463	dimer interface [polypeptide binding]; other site
996634001464	putative PBP binding regions; other site
996634001465	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
996634001466	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
996634001467	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
996634001468	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
996634001469	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
996634001470	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
996634001471	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
996634001472	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
996634001473	homodimer interface [polypeptide binding]; other site
996634001474	NADP binding site [chemical binding]; other site
996634001475	substrate binding site [chemical binding]; other site
996634001476	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
996634001477	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
996634001478	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
996634001479	Htaa; Region: HtaA; pfam04213
996634001480	Htaa; Region: HtaA; pfam04213
996634001481	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
996634001482	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634001483	intersubunit interface [polypeptide binding]; other site
996634001484	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
996634001485	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634001486	ABC-ATPase subunit  interface; other site
996634001487	dimer interface [polypeptide binding]; other site
996634001488	putative PBP binding regions; other site
996634001489	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
996634001490	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634001491	Walker A/P-loop; other site
996634001492	ATP binding site [chemical binding]; other site
996634001493	Q-loop/lid; other site
996634001494	ABC transporter signature motif; other site
996634001495	Walker B; other site
996634001496	D-loop; other site
996634001497	H-loop/switch region; other site
996634001498	Htaa; Region: HtaA; pfam04213
996634001499	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
996634001500	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
996634001501	homodimer interface [polypeptide binding]; other site
996634001502	substrate-cofactor binding pocket; other site
996634001503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634001504	catalytic residue [active]
996634001505	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
996634001506	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
996634001507	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
996634001508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634001509	putative substrate translocation pore; other site
996634001510	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
996634001511	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996634001512	DNA binding residues [nucleotide binding]
996634001513	dimer interface [polypeptide binding]; other site
996634001514	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
996634001515	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
996634001516	putative catalytic site [active]
996634001517	putative metal binding site [ion binding]; other site
996634001518	putative phosphate binding site [ion binding]; other site
996634001519	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
996634001520	active site
996634001521	substrate binding sites [chemical binding]; other site
996634001522	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
996634001523	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
996634001524	active site
996634001525	HIGH motif; other site
996634001526	dimer interface [polypeptide binding]; other site
996634001527	KMSKS motif; other site
996634001528	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
996634001529	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
996634001530	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
996634001531	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
996634001532	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996634001533	NlpC/P60 family; Region: NLPC_P60; pfam00877
996634001534	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634001535	active site
996634001536	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996634001537	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996634001538	non-specific DNA binding site [nucleotide binding]; other site
996634001539	salt bridge; other site
996634001540	sequence-specific DNA binding site [nucleotide binding]; other site
996634001541	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
996634001542	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
996634001543	active site
996634001544	substrate binding site [chemical binding]; other site
996634001545	metal binding site [ion binding]; metal-binding site
996634001546	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
996634001547	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
996634001548	metal binding site [ion binding]; metal-binding site
996634001549	putative dimer interface [polypeptide binding]; other site
996634001550	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
996634001551	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996634001552	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996634001553	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996634001554	pyruvate carboxylase; Reviewed; Region: PRK12999
996634001555	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996634001556	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996634001557	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
996634001558	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
996634001559	active site
996634001560	catalytic residues [active]
996634001561	metal binding site [ion binding]; metal-binding site
996634001562	homodimer binding site [polypeptide binding]; other site
996634001563	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996634001564	carboxyltransferase (CT) interaction site; other site
996634001565	biotinylation site [posttranslational modification]; other site
996634001566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634001567	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996634001568	putative substrate translocation pore; other site
996634001569	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
996634001570	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996634001571	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
996634001572	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
996634001573	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996634001574	carboxyltransferase (CT) interaction site; other site
996634001575	biotinylation site [posttranslational modification]; other site
996634001576	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
996634001577	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
996634001578	active site residue [active]
996634001579	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
996634001580	active site residue [active]
996634001581	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
996634001582	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
996634001583	Maf-like protein; Region: Maf; pfam02545
996634001584	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
996634001585	active site
996634001586	dimer interface [polypeptide binding]; other site
996634001587	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
996634001588	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
996634001589	substrate binding site [chemical binding]; other site
996634001590	dimer interface [polypeptide binding]; other site
996634001591	ATP binding site [chemical binding]; other site
996634001592	Transcriptional regulators [Transcription]; Region: PurR; COG1609
996634001593	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
996634001594	DNA binding site [nucleotide binding]
996634001595	domain linker motif; other site
996634001596	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
996634001597	putative ligand binding site [chemical binding]; other site
996634001598	dimerization interface [polypeptide binding]; other site
996634001599	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
996634001600	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
996634001601	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
996634001602	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
996634001603	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
996634001604	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
996634001605	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
996634001606	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
996634001607	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
996634001608	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634001609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634001610	Walker A/P-loop; other site
996634001611	ATP binding site [chemical binding]; other site
996634001612	Q-loop/lid; other site
996634001613	ABC transporter signature motif; other site
996634001614	Walker B; other site
996634001615	D-loop; other site
996634001616	H-loop/switch region; other site
996634001617	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
996634001618	ATP-grasp domain; Region: ATP-grasp; pfam02222
996634001619	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
996634001620	Uncharacterized conserved protein [Function unknown]; Region: COG1434
996634001621	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
996634001622	putative active site [active]
996634001623	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
996634001624	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634001625	intersubunit interface [polypeptide binding]; other site
996634001626	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634001627	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634001628	ABC-ATPase subunit  interface; other site
996634001629	dimer interface [polypeptide binding]; other site
996634001630	putative PBP binding regions; other site
996634001631	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634001632	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
996634001633	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
996634001634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001635	dimer interface [polypeptide binding]; other site
996634001636	conserved gate region; other site
996634001637	putative PBP binding loops; other site
996634001638	ABC-ATPase subunit interface; other site
996634001639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001640	dimer interface [polypeptide binding]; other site
996634001641	conserved gate region; other site
996634001642	putative PBP binding loops; other site
996634001643	ABC-ATPase subunit interface; other site
996634001644	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
996634001645	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
996634001646	TIGR03089 family protein; Region: TIGR03089
996634001647	Transcriptional regulator [Transcription]; Region: LytR; COG1316
996634001648	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
996634001649	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
996634001650	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996634001651	active site
996634001652	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996634001653	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
996634001654	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
996634001655	active site
996634001656	Substrate binding site; other site
996634001657	Mg++ binding site; other site
996634001658	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
996634001659	Transcription factor WhiB; Region: Whib; pfam02467
996634001660	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
996634001661	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
996634001662	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
996634001663	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
996634001664	active site
996634001665	substrate binding site [chemical binding]; other site
996634001666	metal binding site [ion binding]; metal-binding site
996634001667	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
996634001668	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
996634001669	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
996634001670	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
996634001671	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
996634001672	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
996634001673	homotetramer interface [polypeptide binding]; other site
996634001674	ligand binding site [chemical binding]; other site
996634001675	catalytic site [active]
996634001676	NAD binding site [chemical binding]; other site
996634001677	thymidylate kinase; Validated; Region: PRK07933
996634001678	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
996634001679	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996634001680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634001681	active site
996634001682	phosphorylation site [posttranslational modification]
996634001683	intermolecular recognition site; other site
996634001684	dimerization interface [polypeptide binding]; other site
996634001685	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996634001686	DNA binding site [nucleotide binding]
996634001687	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
996634001688	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996634001689	dimerization interface [polypeptide binding]; other site
996634001690	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996634001691	dimer interface [polypeptide binding]; other site
996634001692	phosphorylation site [posttranslational modification]
996634001693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634001694	ATP binding site [chemical binding]; other site
996634001695	Mg2+ binding site [ion binding]; other site
996634001696	G-X-G motif; other site
996634001697	lipoprotein LpqB; Provisional; Region: PRK13616
996634001698	Sporulation and spore germination; Region: Germane; pfam10646
996634001699	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
996634001700	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634001701	active site
996634001702	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
996634001703	30S subunit binding site; other site
996634001704	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
996634001705	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996634001706	ATP binding site [chemical binding]; other site
996634001707	putative Mg++ binding site [ion binding]; other site
996634001708	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
996634001709	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
996634001710	nucleotide binding region [chemical binding]; other site
996634001711	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
996634001712	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
996634001713	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
996634001714	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
996634001715	FAD binding pocket [chemical binding]; other site
996634001716	FAD binding motif [chemical binding]; other site
996634001717	phosphate binding motif [ion binding]; other site
996634001718	beta-alpha-beta structure motif; other site
996634001719	NAD binding pocket [chemical binding]; other site
996634001720	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996634001721	catalytic loop [active]
996634001722	iron binding site [ion binding]; other site
996634001723	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
996634001724	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
996634001725	putative di-iron ligands [ion binding]; other site
996634001726	Predicted GTPases [General function prediction only]; Region: COG1162
996634001727	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
996634001728	GTPase/Zn-binding domain interface [polypeptide binding]; other site
996634001729	GTP/Mg2+ binding site [chemical binding]; other site
996634001730	G4 box; other site
996634001731	G5 box; other site
996634001732	G1 box; other site
996634001733	Switch I region; other site
996634001734	G2 box; other site
996634001735	G3 box; other site
996634001736	Switch II region; other site
996634001737	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
996634001738	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
996634001739	active site
996634001740	hinge; other site
996634001741	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
996634001742	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
996634001743	putative deacylase active site [active]
996634001744	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
996634001745	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634001746	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634001747	DNA binding residues [nucleotide binding]
996634001748	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
996634001749	Transcription factor WhiB; Region: Whib; pfam02467
996634001750	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
996634001751	active site
996634001752	catalytic triad [active]
996634001753	oxyanion hole [active]
996634001754	PQQ-like domain; Region: PQQ_2; pfam13360
996634001755	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996634001756	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996634001757	ATP binding site [chemical binding]; other site
996634001758	Mg++ binding site [ion binding]; other site
996634001759	motif III; other site
996634001760	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634001761	nucleotide binding region [chemical binding]; other site
996634001762	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
996634001763	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
996634001764	TIGR02569 family protein; Region: TIGR02569_actnb
996634001765	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
996634001766	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
996634001767	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
996634001768	Part of AAA domain; Region: AAA_19; pfam13245
996634001769	Family description; Region: UvrD_C_2; pfam13538
996634001770	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
996634001771	Ion channel; Region: Ion_trans_2; pfam07885
996634001772	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
996634001773	TrkA-N domain; Region: TrkA_N; pfam02254
996634001774	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
996634001775	putative NADH binding site [chemical binding]; other site
996634001776	putative active site [active]
996634001777	nudix motif; other site
996634001778	putative metal binding site [ion binding]; other site
996634001779	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
996634001780	Part of AAA domain; Region: AAA_19; pfam13245
996634001781	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
996634001782	Family description; Region: UvrD_C_2; pfam13538
996634001783	HRDC domain; Region: HRDC; pfam00570
996634001784	Protein of unknown function DUF45; Region: DUF45; cl00636
996634001785	putative hydrolase; Region: TIGR03624
996634001786	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
996634001787	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
996634001788	hypothetical protein; Validated; Region: PRK00068
996634001789	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
996634001790	potential nonsense mutation: common BLAST hit: gi|220930551|ref|YP_002507460.1| protein of unknown function DUF1696
996634001791	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
996634001792	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996634001793	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
996634001794	acyl-activating enzyme (AAE) consensus motif; other site
996634001795	AMP binding site [chemical binding]; other site
996634001796	active site
996634001797	CoA binding site [chemical binding]; other site
996634001798	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
996634001799	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
996634001800	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
996634001801	putative trimer interface [polypeptide binding]; other site
996634001802	putative CoA binding site [chemical binding]; other site
996634001803	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
996634001804	putative trimer interface [polypeptide binding]; other site
996634001805	putative CoA binding site [chemical binding]; other site
996634001806	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
996634001807	oxaloacetate decarboxylase; Provisional; Region: PRK12330
996634001808	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
996634001809	active site
996634001810	catalytic residues [active]
996634001811	metal binding site [ion binding]; metal-binding site
996634001812	homodimer binding site [polypeptide binding]; other site
996634001813	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
996634001814	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
996634001815	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
996634001816	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996634001817	carboxyltransferase (CT) interaction site; other site
996634001818	biotinylation site [posttranslational modification]; other site
996634001819	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996634001820	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
996634001821	active site
996634001822	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
996634001823	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996634001824	active site
996634001825	peptide chain release factor 2; Validated; Region: prfB; PRK00578
996634001826	This domain is found in peptide chain release factors; Region: PCRF; smart00937
996634001827	RF-1 domain; Region: RF-1; pfam00472
996634001828	AAA domain; Region: AAA_17; pfam13207
996634001829	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
996634001830	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
996634001831	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
996634001832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634001833	Walker A/P-loop; other site
996634001834	ATP binding site [chemical binding]; other site
996634001835	Q-loop/lid; other site
996634001836	ABC transporter signature motif; other site
996634001837	Walker B; other site
996634001838	D-loop; other site
996634001839	H-loop/switch region; other site
996634001840	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
996634001841	FtsX-like permease family; Region: FtsX; pfam02687
996634001842	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
996634001843	SmpB-tmRNA interface; other site
996634001844	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
996634001845	active site clefts [active]
996634001846	zinc binding site [ion binding]; other site
996634001847	dimer interface [polypeptide binding]; other site
996634001848	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
996634001849	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634001850	intersubunit interface [polypeptide binding]; other site
996634001851	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634001852	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634001853	ABC-ATPase subunit  interface; other site
996634001854	dimer interface [polypeptide binding]; other site
996634001855	putative PBP binding regions; other site
996634001856	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634001857	ABC-ATPase subunit  interface; other site
996634001858	dimer interface [polypeptide binding]; other site
996634001859	putative PBP binding regions; other site
996634001860	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
996634001861	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634001862	Walker A/P-loop; other site
996634001863	ATP binding site [chemical binding]; other site
996634001864	Q-loop/lid; other site
996634001865	ABC transporter signature motif; other site
996634001866	Walker B; other site
996634001867	D-loop; other site
996634001868	H-loop/switch region; other site
996634001869	aminotransferase; Validated; Region: PRK07777
996634001870	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634001871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634001872	homodimer interface [polypeptide binding]; other site
996634001873	catalytic residue [active]
996634001874	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
996634001875	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
996634001876	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
996634001877	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634001878	ATP binding site [chemical binding]; other site
996634001879	putative Mg++ binding site [ion binding]; other site
996634001880	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634001881	nucleotide binding region [chemical binding]; other site
996634001882	ATP-binding site [chemical binding]; other site
996634001883	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
996634001884	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
996634001885	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
996634001886	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996634001887	DNA-binding site [nucleotide binding]; DNA binding site
996634001888	RNA-binding motif; other site
996634001889	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
996634001890	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
996634001891	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
996634001892	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
996634001893	potential frameshift: common BLAST hit: gi|38233380|ref|NP_939147.1| putative methyltransferase
996634001894	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
996634001895	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
996634001896	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996634001897	catalytic residue [active]
996634001898	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
996634001899	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
996634001900	dimer interface [polypeptide binding]; other site
996634001901	active site
996634001902	citrylCoA binding site [chemical binding]; other site
996634001903	NADH binding [chemical binding]; other site
996634001904	cationic pore residues; other site
996634001905	oxalacetate/citrate binding site [chemical binding]; other site
996634001906	coenzyme A binding site [chemical binding]; other site
996634001907	catalytic triad [active]
996634001908	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996634001909	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
996634001910	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
996634001911	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
996634001912	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
996634001913	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
996634001914	E-class dimer interface [polypeptide binding]; other site
996634001915	P-class dimer interface [polypeptide binding]; other site
996634001916	active site
996634001917	Cu2+ binding site [ion binding]; other site
996634001918	Zn2+ binding site [ion binding]; other site
996634001919	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996634001920	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996634001921	active site
996634001922	catalytic tetrad [active]
996634001923	enoyl-CoA hydratase; Provisional; Region: PRK06688
996634001924	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996634001925	substrate binding site [chemical binding]; other site
996634001926	oxyanion hole (OAH) forming residues; other site
996634001927	trimer interface [polypeptide binding]; other site
996634001928	Protein of unknown function, DUF485; Region: DUF485; pfam04341
996634001929	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
996634001930	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
996634001931	Na binding site [ion binding]; other site
996634001932	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
996634001933	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
996634001934	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
996634001935	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
996634001936	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
996634001937	multidrug efflux protein NorA; Provisional; Region: PRK00187
996634001938	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
996634001939	cation binding site [ion binding]; other site
996634001940	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
996634001941	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
996634001942	dimer interface [polypeptide binding]; other site
996634001943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634001944	catalytic residue [active]
996634001945	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
996634001946	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996634001947	catalytic residue [active]
996634001948	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
996634001949	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
996634001950	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
996634001951	substrate binding pocket [chemical binding]; other site
996634001952	active site
996634001953	iron coordination sites [ion binding]; other site
996634001954	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
996634001955	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
996634001956	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634001957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634001958	dimer interface [polypeptide binding]; other site
996634001959	conserved gate region; other site
996634001960	putative PBP binding loops; other site
996634001961	ABC-ATPase subunit interface; other site
996634001962	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634001963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
996634001964	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
996634001965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634001966	Walker A/P-loop; other site
996634001967	ATP binding site [chemical binding]; other site
996634001968	Q-loop/lid; other site
996634001969	ABC transporter signature motif; other site
996634001970	Walker B; other site
996634001971	D-loop; other site
996634001972	H-loop/switch region; other site
996634001973	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634001974	Walker A/P-loop; other site
996634001975	ATP binding site [chemical binding]; other site
996634001976	Q-loop/lid; other site
996634001977	ABC transporter signature motif; other site
996634001978	Walker B; other site
996634001979	D-loop; other site
996634001980	H-loop/switch region; other site
996634001981	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
996634001982	active site
996634001983	SAM binding site [chemical binding]; other site
996634001984	homodimer interface [polypeptide binding]; other site
996634001985	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
996634001986	catalytic residues [active]
996634001987	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
996634001988	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
996634001989	folate binding site [chemical binding]; other site
996634001990	NADP+ binding site [chemical binding]; other site
996634001991	thymidylate synthase; Reviewed; Region: thyA; PRK01827
996634001992	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
996634001993	dimerization interface [polypeptide binding]; other site
996634001994	active site
996634001995	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
996634001996	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996634001997	active site
996634001998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634001999	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
996634002000	ATP binding site [chemical binding]; other site
996634002001	putative Mg++ binding site [ion binding]; other site
996634002002	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634002003	nucleotide binding region [chemical binding]; other site
996634002004	ATP-binding site [chemical binding]; other site
996634002005	DEAD/H associated; Region: DEAD_assoc; pfam08494
996634002006	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
996634002007	active site
996634002008	SUMO-1 interface [polypeptide binding]; other site
996634002009	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
996634002010	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
996634002011	putative DNA binding site [nucleotide binding]; other site
996634002012	catalytic residue [active]
996634002013	putative H2TH interface [polypeptide binding]; other site
996634002014	putative catalytic residues [active]
996634002015	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
996634002016	hypothetical protein; Provisional; Region: PRK11770
996634002017	Domain of unknown function (DUF307); Region: DUF307; pfam03733
996634002018	Domain of unknown function (DUF307); Region: DUF307; pfam03733
996634002019	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
996634002020	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
996634002021	active site
996634002022	dimer interface [polypeptide binding]; other site
996634002023	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
996634002024	dimer interface [polypeptide binding]; other site
996634002025	active site
996634002026	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996634002027	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
996634002028	tetramerization interface [polypeptide binding]; other site
996634002029	NAD(P) binding site [chemical binding]; other site
996634002030	catalytic residues [active]
996634002031	hypothetical protein; Provisional; Region: PRK07857
996634002032	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
996634002033	Part of AAA domain; Region: AAA_19; pfam13245
996634002034	Family description; Region: UvrD_C_2; pfam13538
996634002035	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
996634002036	Peptidase family M23; Region: Peptidase_M23; pfam01551
996634002037	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
996634002038	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
996634002039	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
996634002040	active site
996634002041	substrate binding site [chemical binding]; other site
996634002042	cosubstrate binding site; other site
996634002043	catalytic site [active]
996634002044	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
996634002045	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
996634002046	purine monophosphate binding site [chemical binding]; other site
996634002047	dimer interface [polypeptide binding]; other site
996634002048	putative catalytic residues [active]
996634002049	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
996634002050	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
996634002051	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
996634002052	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
996634002053	Walker A/P-loop; other site
996634002054	ATP binding site [chemical binding]; other site
996634002055	Q-loop/lid; other site
996634002056	ABC transporter signature motif; other site
996634002057	Walker B; other site
996634002058	D-loop; other site
996634002059	H-loop/switch region; other site
996634002060	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
996634002061	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996634002062	substrate binding pocket [chemical binding]; other site
996634002063	membrane-bound complex binding site; other site
996634002064	hinge residues; other site
996634002065	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996634002066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634002067	dimer interface [polypeptide binding]; other site
996634002068	conserved gate region; other site
996634002069	putative PBP binding loops; other site
996634002070	ABC-ATPase subunit interface; other site
996634002071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634002072	dimer interface [polypeptide binding]; other site
996634002073	conserved gate region; other site
996634002074	putative PBP binding loops; other site
996634002075	ABC-ATPase subunit interface; other site
996634002076	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
996634002077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634002078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634002079	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
996634002080	30S ribosomal protein S18; Provisional; Region: PRK13401
996634002081	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
996634002082	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
996634002083	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
996634002084	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
996634002085	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
996634002086	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996634002087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634002088	active site
996634002089	phosphorylation site [posttranslational modification]
996634002090	intermolecular recognition site; other site
996634002091	dimerization interface [polypeptide binding]; other site
996634002092	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996634002093	DNA binding site [nucleotide binding]
996634002094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996634002095	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996634002096	dimerization interface [polypeptide binding]; other site
996634002097	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996634002098	dimer interface [polypeptide binding]; other site
996634002099	phosphorylation site [posttranslational modification]
996634002100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634002101	ATP binding site [chemical binding]; other site
996634002102	Mg2+ binding site [ion binding]; other site
996634002103	G-X-G motif; other site
996634002104	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
996634002105	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
996634002106	protein binding site [polypeptide binding]; other site
996634002107	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
996634002108	MPT binding site; other site
996634002109	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
996634002110	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
996634002111	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
996634002112	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
996634002113	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
996634002114	active site
996634002115	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
996634002116	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
996634002117	dimer interface [polypeptide binding]; other site
996634002118	putative functional site; other site
996634002119	putative MPT binding site; other site
996634002120	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
996634002121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
996634002122	Coenzyme A binding pocket [chemical binding]; other site
996634002123	Predicted membrane protein [Function unknown]; Region: COG2259
996634002124	Predicted integral membrane protein [Function unknown]; Region: COG5660
996634002125	Putative zinc-finger; Region: zf-HC2; pfam13490
996634002126	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
996634002127	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
996634002128	BCCT family transporter; Region: BCCT; pfam02028
996634002129	Uncharacterized membrane protein [Function unknown]; Region: COG3949
996634002130	Predicted methyltransferases [General function prediction only]; Region: COG0313
996634002131	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
996634002132	putative SAM binding site [chemical binding]; other site
996634002133	putative homodimer interface [polypeptide binding]; other site
996634002134	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
996634002135	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
996634002136	active site
996634002137	HIGH motif; other site
996634002138	KMSKS motif; other site
996634002139	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
996634002140	tRNA binding surface [nucleotide binding]; other site
996634002141	anticodon binding site; other site
996634002142	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
996634002143	active site
996634002144	Domain of unknown function (DUF348); Region: DUF348; pfam03990
996634002145	Domain of unknown function (DUF348); Region: DUF348; pfam03990
996634002146	G5 domain; Region: G5; pfam07501
996634002147	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
996634002148	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
996634002149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634002150	S-adenosylmethionine binding site [chemical binding]; other site
996634002151	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
996634002152	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
996634002153	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
996634002154	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634002155	ABC transporter; Region: ABC_tran_2; pfam12848
996634002156	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634002157	Uncharacterized conserved protein [Function unknown]; Region: COG1359
996634002158	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
996634002159	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634002160	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
996634002161	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
996634002162	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
996634002163	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634002164	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
996634002165	active site
996634002166	motif I; other site
996634002167	motif II; other site
996634002168	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
996634002169	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
996634002170	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996634002171	substrate binding site [chemical binding]; other site
996634002172	oxyanion hole (OAH) forming residues; other site
996634002173	trimer interface [polypeptide binding]; other site
996634002174	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
996634002175	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
996634002176	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
996634002177	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
996634002178	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
996634002179	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
996634002180	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
996634002181	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
996634002182	G1 box; other site
996634002183	putative GEF interaction site [polypeptide binding]; other site
996634002184	GTP/Mg2+ binding site [chemical binding]; other site
996634002185	Switch I region; other site
996634002186	G2 box; other site
996634002187	G3 box; other site
996634002188	Switch II region; other site
996634002189	G4 box; other site
996634002190	G5 box; other site
996634002191	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
996634002192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634002193	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
996634002194	NAD(P) binding site [chemical binding]; other site
996634002195	active site
996634002196	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
996634002197	putative active site [active]
996634002198	catalytic residue [active]
996634002199	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
996634002200	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
996634002201	FMN binding site [chemical binding]; other site
996634002202	substrate binding site [chemical binding]; other site
996634002203	putative catalytic residue [active]
996634002204	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
996634002205	putative active site [active]
996634002206	catalytic residue [active]
996634002207	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
996634002208	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
996634002209	5S rRNA interface [nucleotide binding]; other site
996634002210	CTC domain interface [polypeptide binding]; other site
996634002211	L16 interface [polypeptide binding]; other site
996634002212	pullulanase, type I; Region: pulA_typeI; TIGR02104
996634002213	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
996634002214	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
996634002215	Ca binding site [ion binding]; other site
996634002216	active site
996634002217	catalytic site [active]
996634002218	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
996634002219	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
996634002220	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634002221	active site
996634002222	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
996634002223	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
996634002224	Substrate binding site; other site
996634002225	Mg++ binding site; other site
996634002226	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
996634002227	active site
996634002228	substrate binding site [chemical binding]; other site
996634002229	CoA binding site [chemical binding]; other site
996634002230	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
996634002231	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
996634002232	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
996634002233	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
996634002234	gating phenylalanine in ion channel; other site
996634002235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634002236	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634002237	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
996634002238	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
996634002239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634002240	ATP binding site [chemical binding]; other site
996634002241	putative Mg++ binding site [ion binding]; other site
996634002242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634002243	nucleotide binding region [chemical binding]; other site
996634002244	ATP-binding site [chemical binding]; other site
996634002245	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
996634002246	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
996634002247	Spore germination protein; Region: Spore_permease; cl17796
996634002248	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
996634002249	homodimer interface [polypeptide binding]; other site
996634002250	metal binding site [ion binding]; metal-binding site
996634002251	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
996634002252	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996634002253	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996634002254	enolase; Provisional; Region: eno; PRK00077
996634002255	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
996634002256	dimer interface [polypeptide binding]; other site
996634002257	metal binding site [ion binding]; metal-binding site
996634002258	substrate binding pocket [chemical binding]; other site
996634002259	Septum formation initiator; Region: DivIC; pfam04977
996634002260	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
996634002261	Uncharacterized conserved protein [Function unknown]; Region: COG1507
996634002262	exopolyphosphatase; Region: exo_poly_only; TIGR03706
996634002263	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
996634002264	Helix-turn-helix domain; Region: HTH_18; pfam12833
996634002265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996634002266	Bax inhibitor 1 like; Region: BaxI_1; cl17691
996634002267	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
996634002268	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
996634002269	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
996634002270	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
996634002271	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
996634002272	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
996634002273	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
996634002274	catalytic residue [active]
996634002275	putative FPP diphosphate  binding site; other site
996634002276	putative FPP binding hydrophobic cleft; other site
996634002277	dimer interface [polypeptide binding]; other site
996634002278	putative IPP diphosphate binding site; other site
996634002279	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
996634002280	pantothenate kinase; Provisional; Region: PRK05439
996634002281	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
996634002282	ATP-binding site [chemical binding]; other site
996634002283	CoA-binding site [chemical binding]; other site
996634002284	Mg2+-binding site [ion binding]; other site
996634002285	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
996634002286	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
996634002287	dimer interface [polypeptide binding]; other site
996634002288	active site
996634002289	glycine-pyridoxal phosphate binding site [chemical binding]; other site
996634002290	folate binding site [chemical binding]; other site
996634002291	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996634002292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634002293	putative substrate translocation pore; other site
996634002294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634002295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634002296	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
996634002297	dimerization interface [polypeptide binding]; other site
996634002298	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996634002299	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
996634002300	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
996634002301	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634002302	Coenzyme A binding pocket [chemical binding]; other site
996634002303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634002304	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996634002305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634002306	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634002307	fumarate hydratase; Reviewed; Region: fumC; PRK00485
996634002308	Class II fumarases; Region: Fumarase_classII; cd01362
996634002309	active site
996634002310	tetramer interface [polypeptide binding]; other site
996634002311	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
996634002312	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
996634002313	putative active site [active]
996634002314	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
996634002315	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
996634002316	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
996634002317	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
996634002318	generic binding surface II; other site
996634002319	generic binding surface I; other site
996634002320	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
996634002321	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
996634002322	Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616
996634002323	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
996634002324	Domain of unknown function DUF20; Region: UPF0118; pfam01594
996634002325	GTP-binding protein YchF; Reviewed; Region: PRK09601
996634002326	YchF GTPase; Region: YchF; cd01900
996634002327	G1 box; other site
996634002328	GTP/Mg2+ binding site [chemical binding]; other site
996634002329	Switch I region; other site
996634002330	G2 box; other site
996634002331	Switch II region; other site
996634002332	G3 box; other site
996634002333	G4 box; other site
996634002334	G5 box; other site
996634002335	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
996634002336	Alkylmercury lyase; Region: MerB; pfam03243
996634002337	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
996634002338	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
996634002339	PhnA protein; Region: PhnA; pfam03831
996634002340	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996634002341	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996634002342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002343	Walker A/P-loop; other site
996634002344	ATP binding site [chemical binding]; other site
996634002345	Q-loop/lid; other site
996634002346	ABC transporter signature motif; other site
996634002347	Walker B; other site
996634002348	D-loop; other site
996634002349	H-loop/switch region; other site
996634002350	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
996634002351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002352	Walker A/P-loop; other site
996634002353	ATP binding site [chemical binding]; other site
996634002354	Q-loop/lid; other site
996634002355	ABC transporter signature motif; other site
996634002356	Walker B; other site
996634002357	D-loop; other site
996634002358	H-loop/switch region; other site
996634002359	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
996634002360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002361	Walker A/P-loop; other site
996634002362	ATP binding site [chemical binding]; other site
996634002363	Q-loop/lid; other site
996634002364	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
996634002365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002366	Walker A/P-loop; other site
996634002367	ATP binding site [chemical binding]; other site
996634002368	Q-loop/lid; other site
996634002369	ABC transporter signature motif; other site
996634002370	Walker B; other site
996634002371	D-loop; other site
996634002372	H-loop/switch region; other site
996634002373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
996634002374	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
996634002375	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
996634002376	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
996634002377	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
996634002378	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
996634002379	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
996634002380	Walker A/P-loop; other site
996634002381	ATP binding site [chemical binding]; other site
996634002382	Q-loop/lid; other site
996634002383	ABC transporter signature motif; other site
996634002384	Walker B; other site
996634002385	D-loop; other site
996634002386	H-loop/switch region; other site
996634002387	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
996634002388	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
996634002389	Q-loop/lid; other site
996634002390	ABC transporter signature motif; other site
996634002391	Walker B; other site
996634002392	D-loop; other site
996634002393	H-loop/switch region; other site
996634002394	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
996634002395	hypothetical protein; Provisional; Region: PRK06547
996634002396	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
996634002397	nudix motif; other site
996634002398	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
996634002399	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
996634002400	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634002401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634002402	dimer interface [polypeptide binding]; other site
996634002403	conserved gate region; other site
996634002404	ABC-ATPase subunit interface; other site
996634002405	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634002406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634002407	dimer interface [polypeptide binding]; other site
996634002408	conserved gate region; other site
996634002409	putative PBP binding loops; other site
996634002410	ABC-ATPase subunit interface; other site
996634002411	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
996634002412	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634002413	Walker A/P-loop; other site
996634002414	ATP binding site [chemical binding]; other site
996634002415	Q-loop/lid; other site
996634002416	ABC transporter signature motif; other site
996634002417	Walker B; other site
996634002418	D-loop; other site
996634002419	H-loop/switch region; other site
996634002420	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634002421	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634002422	Walker A/P-loop; other site
996634002423	ATP binding site [chemical binding]; other site
996634002424	Q-loop/lid; other site
996634002425	ABC transporter signature motif; other site
996634002426	Walker B; other site
996634002427	D-loop; other site
996634002428	H-loop/switch region; other site
996634002429	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634002430	Predicted transcriptional regulators [Transcription]; Region: COG1695
996634002431	Transcriptional regulator PadR-like family; Region: PadR; cl17335
996634002432	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634002433	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996634002434	Walker A/P-loop; other site
996634002435	ATP binding site [chemical binding]; other site
996634002436	Q-loop/lid; other site
996634002437	ABC transporter signature motif; other site
996634002438	Walker B; other site
996634002439	D-loop; other site
996634002440	H-loop/switch region; other site
996634002441	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
996634002442	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
996634002443	cleavage site
996634002444	active site
996634002445	substrate binding sites [chemical binding]; other site
996634002446	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
996634002447	ArsC family; Region: ArsC; pfam03960
996634002448	catalytic residues [active]
996634002449	Protein of unknown function (DUF402); Region: DUF402; cl00979
996634002450	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
996634002451	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
996634002452	G1 box; other site
996634002453	GTP/Mg2+ binding site [chemical binding]; other site
996634002454	G2 box; other site
996634002455	Switch I region; other site
996634002456	G3 box; other site
996634002457	Switch II region; other site
996634002458	G4 box; other site
996634002459	G5 box; other site
996634002460	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
996634002461	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
996634002462	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
996634002463	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
996634002464	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
996634002465	Ferredoxin [Energy production and conversion]; Region: COG1146
996634002466	4Fe-4S binding domain; Region: Fer4; pfam00037
996634002467	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
996634002468	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634002469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634002470	homodimer interface [polypeptide binding]; other site
996634002471	catalytic residue [active]
996634002472	Predicted membrane protein [Function unknown]; Region: COG2246
996634002473	GtrA-like protein; Region: GtrA; pfam04138
996634002474	Domain of unknown function (DUF222); Region: DUF222; pfam02720
996634002475	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
996634002476	active site
996634002477	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
996634002478	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
996634002479	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
996634002480	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
996634002481	putative trimer interface [polypeptide binding]; other site
996634002482	putative CoA binding site [chemical binding]; other site
996634002483	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
996634002484	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
996634002485	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
996634002486	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
996634002487	putative trimer interface [polypeptide binding]; other site
996634002488	putative CoA binding site [chemical binding]; other site
996634002489	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
996634002490	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
996634002491	metal binding site [ion binding]; metal-binding site
996634002492	putative dimer interface [polypeptide binding]; other site
996634002493	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
996634002494	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
996634002495	dihydropteroate synthase; Region: DHPS; TIGR01496
996634002496	substrate binding pocket [chemical binding]; other site
996634002497	dimer interface [polypeptide binding]; other site
996634002498	inhibitor binding site; inhibition site
996634002499	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
996634002500	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
996634002501	Ligand binding site; other site
996634002502	Putative Catalytic site; other site
996634002503	DXD motif; other site
996634002504	DivIVA domain; Region: DivI1A_domain; TIGR03544
996634002505	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
996634002506	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
996634002507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634002508	S-adenosylmethionine binding site [chemical binding]; other site
996634002509	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
996634002510	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
996634002511	active site
996634002512	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
996634002513	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
996634002514	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
996634002515	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
996634002516	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
996634002517	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
996634002518	ligand binding site; other site
996634002519	oligomer interface; other site
996634002520	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
996634002521	dimer interface [polypeptide binding]; other site
996634002522	N-terminal domain interface [polypeptide binding]; other site
996634002523	sulfate 1 binding site; other site
996634002524	Methyltransferase domain; Region: Methyltransf_24; pfam13578
996634002525	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
996634002526	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634002527	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634002528	DNA binding residues [nucleotide binding]
996634002529	sec-independent translocase; Provisional; Region: tatB; PRK00182
996634002530	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
996634002531	antiporter inner membrane protein; Provisional; Region: PRK11670
996634002532	Domain of unknown function DUF59; Region: DUF59; pfam01883
996634002533	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
996634002534	Predicted membrane protein [Function unknown]; Region: COG4420
996634002535	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
996634002536	MgtE intracellular N domain; Region: MgtE_N; smart00924
996634002537	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
996634002538	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
996634002539	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
996634002540	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
996634002541	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
996634002542	TPP-binding site [chemical binding]; other site
996634002543	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
996634002544	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996634002545	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996634002546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002547	Walker A/P-loop; other site
996634002548	ATP binding site [chemical binding]; other site
996634002549	Q-loop/lid; other site
996634002550	ABC transporter signature motif; other site
996634002551	Walker B; other site
996634002552	D-loop; other site
996634002553	H-loop/switch region; other site
996634002554	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996634002555	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996634002556	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002557	Walker A/P-loop; other site
996634002558	ATP binding site [chemical binding]; other site
996634002559	Q-loop/lid; other site
996634002560	ABC transporter signature motif; other site
996634002561	Walker B; other site
996634002562	D-loop; other site
996634002563	H-loop/switch region; other site
996634002564	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
996634002565	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
996634002566	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
996634002567	shikimate binding site; other site
996634002568	NAD(P) binding site [chemical binding]; other site
996634002569	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
996634002570	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
996634002571	substrate binding pocket [chemical binding]; other site
996634002572	catalytic triad [active]
996634002573	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
996634002574	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
996634002575	active site
996634002576	catalytic residues [active]
996634002577	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
996634002578	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
996634002579	Na binding site [ion binding]; other site
996634002580	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
996634002581	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
996634002582	nucleotide binding site/active site [active]
996634002583	HIT family signature motif; other site
996634002584	catalytic residue [active]
996634002585	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
996634002586	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
996634002587	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
996634002588	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
996634002589	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996634002590	ATP binding site [chemical binding]; other site
996634002591	Mg++ binding site [ion binding]; other site
996634002592	motif III; other site
996634002593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634002594	nucleotide binding region [chemical binding]; other site
996634002595	ATP-binding site [chemical binding]; other site
996634002596	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
996634002597	putative RNA binding site [nucleotide binding]; other site
996634002598	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
996634002599	dimer interface [polypeptide binding]; other site
996634002600	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996634002601	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
996634002602	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
996634002603	Na binding site [ion binding]; other site
996634002604	SNF2 Helicase protein; Region: DUF3670; pfam12419
996634002605	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
996634002606	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634002607	ATP binding site [chemical binding]; other site
996634002608	putative Mg++ binding site [ion binding]; other site
996634002609	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634002610	nucleotide binding region [chemical binding]; other site
996634002611	ATP-binding site [chemical binding]; other site
996634002612	Uncharacterized conserved protein [Function unknown]; Region: COG4279
996634002613	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
996634002614	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
996634002615	active site
996634002616	metal binding site [ion binding]; metal-binding site
996634002617	DNA binding site [nucleotide binding]
996634002618	AAA domain; Region: AAA_23; pfam13476
996634002619	Uncharacterized conserved protein [Function unknown]; Region: COG2353
996634002620	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
996634002621	MarR family; Region: MarR_2; pfam12802
996634002622	PspC domain; Region: PspC; pfam04024
996634002623	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
996634002624	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
996634002625	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
996634002626	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
996634002627	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
996634002628	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
996634002629	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
996634002630	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
996634002631	Cysteine-rich domain; Region: CCG; pfam02754
996634002632	Cysteine-rich domain; Region: CCG; pfam02754
996634002633	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
996634002634	L-lactate permease; Region: Lactate_perm; cl00701
996634002635	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
996634002636	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
996634002637	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
996634002638	active site
996634002639	HIGH motif; other site
996634002640	KMSK motif region; other site
996634002641	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
996634002642	tRNA binding surface [nucleotide binding]; other site
996634002643	anticodon binding site; other site
996634002644	diaminopimelate decarboxylase; Region: lysA; TIGR01048
996634002645	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
996634002646	active site
996634002647	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996634002648	substrate binding site [chemical binding]; other site
996634002649	catalytic residues [active]
996634002650	dimer interface [polypeptide binding]; other site
996634002651	homoserine dehydrogenase; Provisional; Region: PRK06349
996634002652	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
996634002653	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
996634002654	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
996634002655	homoserine kinase; Provisional; Region: PRK01212
996634002656	Predicted transcriptional regulator [Transcription]; Region: COG2345
996634002657	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
996634002658	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996634002659	acyl-activating enzyme (AAE) consensus motif; other site
996634002660	AMP binding site [chemical binding]; other site
996634002661	active site
996634002662	CoA binding site [chemical binding]; other site
996634002663	transcription termination factor Rho; Provisional; Region: PRK12678
996634002664	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
996634002665	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
996634002666	RNA binding site [nucleotide binding]; other site
996634002667	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
996634002668	multimer interface [polypeptide binding]; other site
996634002669	Walker A motif; other site
996634002670	ATP binding site [chemical binding]; other site
996634002671	Walker B motif; other site
996634002672	peptide chain release factor 1; Validated; Region: prfA; PRK00591
996634002673	This domain is found in peptide chain release factors; Region: PCRF; smart00937
996634002674	RF-1 domain; Region: RF-1; pfam00472
996634002675	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
996634002676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634002677	S-adenosylmethionine binding site [chemical binding]; other site
996634002678	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
996634002679	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
996634002680	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
996634002681	Mg++ binding site [ion binding]; other site
996634002682	putative catalytic motif [active]
996634002683	substrate binding site [chemical binding]; other site
996634002684	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
996634002685	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
996634002686	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
996634002687	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
996634002688	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
996634002689	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
996634002690	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
996634002691	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
996634002692	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
996634002693	beta subunit interaction interface [polypeptide binding]; other site
996634002694	Walker A motif; other site
996634002695	ATP binding site [chemical binding]; other site
996634002696	Walker B motif; other site
996634002697	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
996634002698	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
996634002699	core domain interface [polypeptide binding]; other site
996634002700	delta subunit interface [polypeptide binding]; other site
996634002701	epsilon subunit interface [polypeptide binding]; other site
996634002702	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
996634002703	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
996634002704	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
996634002705	alpha subunit interaction interface [polypeptide binding]; other site
996634002706	Walker A motif; other site
996634002707	ATP binding site [chemical binding]; other site
996634002708	Walker B motif; other site
996634002709	inhibitor binding site; inhibition site
996634002710	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
996634002711	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
996634002712	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
996634002713	gamma subunit interface [polypeptide binding]; other site
996634002714	epsilon subunit interface [polypeptide binding]; other site
996634002715	LBP interface [polypeptide binding]; other site
996634002716	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
996634002717	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
996634002718	hypothetical protein; Provisional; Region: PRK03298
996634002719	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
996634002720	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996634002721	dimer interface [polypeptide binding]; other site
996634002722	substrate binding site [chemical binding]; other site
996634002723	metal binding site [ion binding]; metal-binding site
996634002724	Domain of unknown function DUF77; Region: DUF77; pfam01910
996634002725	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
996634002726	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
996634002727	glycogen branching enzyme; Provisional; Region: PRK05402
996634002728	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
996634002729	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
996634002730	active site
996634002731	catalytic site [active]
996634002732	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
996634002733	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
996634002734	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
996634002735	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
996634002736	active site
996634002737	catalytic site [active]
996634002738	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
996634002739	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002740	Walker A/P-loop; other site
996634002741	ATP binding site [chemical binding]; other site
996634002742	ABC transporter signature motif; other site
996634002743	Walker B; other site
996634002744	D-loop; other site
996634002745	H-loop/switch region; other site
996634002746	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
996634002747	Ligand binding site [chemical binding]; other site
996634002748	Electron transfer flavoprotein domain; Region: ETF; pfam01012
996634002749	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
996634002750	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
996634002751	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
996634002752	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
996634002753	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
996634002754	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996634002755	catalytic residue [active]
996634002756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634002757	S-adenosylmethionine binding site [chemical binding]; other site
996634002758	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
996634002759	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
996634002760	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
996634002761	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
996634002762	active site
996634002763	catalytic site [active]
996634002764	substrate binding site [chemical binding]; other site
996634002765	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
996634002766	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
996634002767	nucleotide binding pocket [chemical binding]; other site
996634002768	K-X-D-G motif; other site
996634002769	catalytic site [active]
996634002770	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
996634002771	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
996634002772	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
996634002773	Dimer interface [polypeptide binding]; other site
996634002774	BRCT sequence motif; other site
996634002775	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
996634002776	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
996634002777	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
996634002778	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
996634002779	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
996634002780	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634002781	Coenzyme A binding pocket [chemical binding]; other site
996634002782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634002783	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996634002784	putative substrate translocation pore; other site
996634002785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634002786	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634002787	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634002788	ABC-ATPase subunit  interface; other site
996634002789	dimer interface [polypeptide binding]; other site
996634002790	putative PBP binding regions; other site
996634002791	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634002792	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634002793	Walker A/P-loop; other site
996634002794	ATP binding site [chemical binding]; other site
996634002795	Q-loop/lid; other site
996634002796	ABC transporter signature motif; other site
996634002797	Walker B; other site
996634002798	D-loop; other site
996634002799	H-loop/switch region; other site
996634002800	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
996634002801	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
996634002802	putative ligand binding residues [chemical binding]; other site
996634002803	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
996634002804	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
996634002805	phosphofructokinase; Region: PFK_mixed; TIGR02483
996634002806	active site
996634002807	ADP/pyrophosphate binding site [chemical binding]; other site
996634002808	dimerization interface [polypeptide binding]; other site
996634002809	allosteric effector site; other site
996634002810	fructose-1,6-bisphosphate binding site; other site
996634002811	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
996634002812	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
996634002813	GatB domain; Region: GatB_Yqey; smart00845
996634002814	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996634002815	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996634002816	active site
996634002817	catalytic tetrad [active]
996634002818	Lysine efflux permease [General function prediction only]; Region: COG1279
996634002819	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
996634002820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996634002821	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996634002822	dimerization interface [polypeptide binding]; other site
996634002823	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
996634002824	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
996634002825	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
996634002826	putative dimer interface [polypeptide binding]; other site
996634002827	N-terminal domain interface [polypeptide binding]; other site
996634002828	putative substrate binding pocket (H-site) [chemical binding]; other site
996634002829	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
996634002830	Predicted membrane protein [Function unknown]; Region: COG2259
996634002831	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
996634002832	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
996634002833	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996634002834	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996634002835	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
996634002836	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
996634002837	PYR/PP interface [polypeptide binding]; other site
996634002838	dimer interface [polypeptide binding]; other site
996634002839	TPP binding site [chemical binding]; other site
996634002840	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
996634002841	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
996634002842	TPP-binding site [chemical binding]; other site
996634002843	dimer interface [polypeptide binding]; other site
996634002844	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
996634002845	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
996634002846	putative valine binding site [chemical binding]; other site
996634002847	dimer interface [polypeptide binding]; other site
996634002848	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
996634002849	ketol-acid reductoisomerase; Provisional; Region: PRK05479
996634002850	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
996634002851	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
996634002852	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
996634002853	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
996634002854	Uncharacterized conserved protein [Function unknown]; Region: COG1479
996634002855	Protein of unknown function DUF262; Region: DUF262; pfam03235
996634002856	Uncharacterized conserved protein [Function unknown]; Region: COG3472
996634002857	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
996634002858	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
996634002859	ligand binding site [chemical binding]; other site
996634002860	NAD binding site [chemical binding]; other site
996634002861	dimerization interface [polypeptide binding]; other site
996634002862	catalytic site [active]
996634002863	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
996634002864	putative L-serine binding site [chemical binding]; other site
996634002865	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
996634002866	tartrate dehydrogenase; Region: TTC; TIGR02089
996634002867	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
996634002868	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996634002869	ligand binding site [chemical binding]; other site
996634002870	flexible hinge region; other site
996634002871	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
996634002872	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996634002873	metal binding triad; other site
996634002874	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
996634002875	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
996634002876	active site
996634002877	catalytic site [active]
996634002878	substrate binding site [chemical binding]; other site
996634002879	hypothetical protein; Provisional; Region: PRK06771
996634002880	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
996634002881	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
996634002882	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
996634002883	Methyltransferase domain; Region: Methyltransf_23; pfam13489
996634002884	Methyltransferase domain; Region: Methyltransf_18; pfam12847
996634002885	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
996634002886	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
996634002887	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
996634002888	active site
996634002889	HIGH motif; other site
996634002890	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
996634002891	active site
996634002892	KMSKS motif; other site
996634002893	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
996634002894	Cutinase; Region: Cutinase; pfam01083
996634002895	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
996634002896	HsdM N-terminal domain; Region: HsdM_N; pfam12161
996634002897	Methyltransferase domain; Region: Methyltransf_26; pfam13659
996634002898	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
996634002899	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
996634002900	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
996634002901	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
996634002902	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
996634002903	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634002904	ATP binding site [chemical binding]; other site
996634002905	putative Mg++ binding site [ion binding]; other site
996634002906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634002907	ABC transporter signature motif; other site
996634002908	Walker B; other site
996634002909	D-loop; other site
996634002910	H-loop/switch region; other site
996634002911	Protein of unknown function DUF91; Region: DUF91; cl00709
996634002912	Uncharacterized conserved protein [Function unknown]; Region: COG3586
996634002913	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
996634002914	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634002915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634002916	dimer interface [polypeptide binding]; other site
996634002917	conserved gate region; other site
996634002918	putative PBP binding loops; other site
996634002919	ABC-ATPase subunit interface; other site
996634002920	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634002921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634002922	dimer interface [polypeptide binding]; other site
996634002923	conserved gate region; other site
996634002924	putative PBP binding loops; other site
996634002925	ABC-ATPase subunit interface; other site
996634002926	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634002927	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634002928	Walker A/P-loop; other site
996634002929	ATP binding site [chemical binding]; other site
996634002930	Q-loop/lid; other site
996634002931	ABC transporter signature motif; other site
996634002932	Walker B; other site
996634002933	D-loop; other site
996634002934	H-loop/switch region; other site
996634002935	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
996634002936	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634002937	Walker A/P-loop; other site
996634002938	ATP binding site [chemical binding]; other site
996634002939	Q-loop/lid; other site
996634002940	ABC transporter signature motif; other site
996634002941	Walker B; other site
996634002942	D-loop; other site
996634002943	H-loop/switch region; other site
996634002944	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
996634002945	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
996634002946	biotin synthase; Region: bioB; TIGR00433
996634002947	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634002948	FeS/SAM binding site; other site
996634002949	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
996634002950	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
996634002951	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996634002952	Zn2+ binding site [ion binding]; other site
996634002953	Mg2+ binding site [ion binding]; other site
996634002954	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
996634002955	Transcriptional regulator [Transcription]; Region: IclR; COG1414
996634002956	Bacterial transcriptional regulator; Region: IclR; pfam01614
996634002957	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
996634002958	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
996634002959	substrate binding site [chemical binding]; other site
996634002960	ligand binding site [chemical binding]; other site
996634002961	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
996634002962	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
996634002963	substrate binding site [chemical binding]; other site
996634002964	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
996634002965	active site
996634002966	Ap6A binding site [chemical binding]; other site
996634002967	nudix motif; other site
996634002968	metal binding site [ion binding]; metal-binding site
996634002969	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634002970	catalytic core [active]
996634002971	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
996634002972	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
996634002973	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
996634002974	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
996634002975	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
996634002976	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996634002977	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
996634002978	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
996634002979	thiamine monophosphate kinase; Provisional; Region: PRK05731
996634002980	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
996634002981	ATP binding site [chemical binding]; other site
996634002982	dimerization interface [polypeptide binding]; other site
996634002983	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
996634002984	ligand binding site [chemical binding]; other site
996634002985	active site
996634002986	UGI interface [polypeptide binding]; other site
996634002987	catalytic site [active]
996634002988	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
996634002989	DAK2 domain; Region: Dak2; pfam02734
996634002990	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
996634002991	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
996634002992	generic binding surface II; other site
996634002993	ssDNA binding site; other site
996634002994	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634002995	ATP binding site [chemical binding]; other site
996634002996	putative Mg++ binding site [ion binding]; other site
996634002997	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634002998	nucleotide binding region [chemical binding]; other site
996634002999	ATP-binding site [chemical binding]; other site
996634003000	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
996634003001	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996634003002	carboxyltransferase (CT) interaction site; other site
996634003003	biotinylation site [posttranslational modification]; other site
996634003004	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
996634003005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634003006	S-adenosylmethionine binding site [chemical binding]; other site
996634003007	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
996634003008	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
996634003009	active site
996634003010	(T/H)XGH motif; other site
996634003011	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996634003012	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
996634003013	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
996634003014	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
996634003015	Walker A/P-loop; other site
996634003016	ATP binding site [chemical binding]; other site
996634003017	Q-loop/lid; other site
996634003018	ABC transporter signature motif; other site
996634003019	Walker B; other site
996634003020	D-loop; other site
996634003021	H-loop/switch region; other site
996634003022	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634003023	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996634003024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634003025	dimer interface [polypeptide binding]; other site
996634003026	conserved gate region; other site
996634003027	putative PBP binding loops; other site
996634003028	ABC-ATPase subunit interface; other site
996634003029	Membrane-associated tegument protein; Region: UL11; cl17374
996634003030	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996634003031	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996634003032	substrate binding pocket [chemical binding]; other site
996634003033	membrane-bound complex binding site; other site
996634003034	hinge residues; other site
996634003035	Domain of unknown function (DUF368); Region: DUF368; pfam04018
996634003036	DNA polymerase I; Provisional; Region: PRK05755
996634003037	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
996634003038	active site
996634003039	metal binding site 1 [ion binding]; metal-binding site
996634003040	putative 5' ssDNA interaction site; other site
996634003041	metal binding site 3; metal-binding site
996634003042	metal binding site 2 [ion binding]; metal-binding site
996634003043	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
996634003044	putative DNA binding site [nucleotide binding]; other site
996634003045	putative metal binding site [ion binding]; other site
996634003046	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
996634003047	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
996634003048	active site
996634003049	DNA binding site [nucleotide binding]
996634003050	catalytic site [active]
996634003051	Methyltransferase domain; Region: Methyltransf_31; pfam13847
996634003052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634003053	S-adenosylmethionine binding site [chemical binding]; other site
996634003054	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
996634003055	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
996634003056	RNA binding site [nucleotide binding]; other site
996634003057	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
996634003058	RNA binding site [nucleotide binding]; other site
996634003059	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
996634003060	RNA binding site [nucleotide binding]; other site
996634003061	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
996634003062	RNA binding site [nucleotide binding]; other site
996634003063	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
996634003064	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
996634003065	active site turn [active]
996634003066	phosphorylation site [posttranslational modification]
996634003067	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
996634003068	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
996634003069	HPr interaction site; other site
996634003070	glycerol kinase (GK) interaction site [polypeptide binding]; other site
996634003071	active site
996634003072	phosphorylation site [posttranslational modification]
996634003073	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
996634003074	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
996634003075	CoA-binding site [chemical binding]; other site
996634003076	ATP-binding [chemical binding]; other site
996634003077	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
996634003078	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634003079	FeS/SAM binding site; other site
996634003080	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
996634003081	excinuclease ABC subunit B; Provisional; Region: PRK05298
996634003082	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634003083	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634003084	nucleotide binding region [chemical binding]; other site
996634003085	ATP-binding site [chemical binding]; other site
996634003086	Ultra-violet resistance protein B; Region: UvrB; pfam12344
996634003087	UvrB/uvrC motif; Region: UVR; pfam02151
996634003088	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634003089	Ligand Binding Site [chemical binding]; other site
996634003090	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
996634003091	Part of AAA domain; Region: AAA_19; pfam13245
996634003092	PhoH-like protein; Region: PhoH; cl17668
996634003093	Family description; Region: UvrD_C_2; pfam13538
996634003094	Predicted membrane protein [Function unknown]; Region: COG2259
996634003095	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996634003096	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
996634003097	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
996634003098	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
996634003099	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
996634003100	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
996634003101	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
996634003102	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
996634003103	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
996634003104	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
996634003105	23S rRNA binding site [nucleotide binding]; other site
996634003106	L21 binding site [polypeptide binding]; other site
996634003107	L13 binding site [polypeptide binding]; other site
996634003108	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
996634003109	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
996634003110	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
996634003111	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
996634003112	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
996634003113	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
996634003114	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
996634003115	dimer interface [polypeptide binding]; other site
996634003116	motif 1; other site
996634003117	active site
996634003118	motif 2; other site
996634003119	motif 3; other site
996634003120	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
996634003121	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
996634003122	putative tRNA-binding site [nucleotide binding]; other site
996634003123	B3/4 domain; Region: B3_4; pfam03483
996634003124	tRNA synthetase B5 domain; Region: B5; smart00874
996634003125	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
996634003126	dimer interface [polypeptide binding]; other site
996634003127	motif 1; other site
996634003128	motif 3; other site
996634003129	motif 2; other site
996634003130	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
996634003131	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
996634003132	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
996634003133	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
996634003134	heterotetramer interface [polypeptide binding]; other site
996634003135	active site pocket [active]
996634003136	cleavage site
996634003137	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
996634003138	feedback inhibition sensing region; other site
996634003139	homohexameric interface [polypeptide binding]; other site
996634003140	nucleotide binding site [chemical binding]; other site
996634003141	N-acetyl-L-glutamate binding site [chemical binding]; other site
996634003142	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
996634003143	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996634003144	inhibitor-cofactor binding pocket; inhibition site
996634003145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634003146	catalytic residue [active]
996634003147	ornithine carbamoyltransferase; Provisional; Region: PRK00779
996634003148	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
996634003149	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
996634003150	arginine repressor; Provisional; Region: PRK03341
996634003151	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
996634003152	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
996634003153	argininosuccinate synthase; Provisional; Region: PRK13820
996634003154	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
996634003155	ANP binding site [chemical binding]; other site
996634003156	Substrate Binding Site II [chemical binding]; other site
996634003157	Substrate Binding Site I [chemical binding]; other site
996634003158	argininosuccinate lyase; Provisional; Region: PRK00855
996634003159	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
996634003160	active sites [active]
996634003161	tetramer interface [polypeptide binding]; other site
996634003162	Uncharacterized conserved protein [Function unknown]; Region: COG2835
996634003163	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
996634003164	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
996634003165	active site
996634003166	HIGH motif; other site
996634003167	dimer interface [polypeptide binding]; other site
996634003168	KMSKS motif; other site
996634003169	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634003170	RNA binding surface [nucleotide binding]; other site
996634003171	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
996634003172	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
996634003173	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634003174	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
996634003175	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634003176	RNA binding surface [nucleotide binding]; other site
996634003177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634003178	S-adenosylmethionine binding site [chemical binding]; other site
996634003179	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
996634003180	ATP-NAD kinase; Region: NAD_kinase; pfam01513
996634003181	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
996634003182	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
996634003183	Walker A/P-loop; other site
996634003184	ATP binding site [chemical binding]; other site
996634003185	Q-loop/lid; other site
996634003186	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
996634003187	ABC transporter signature motif; other site
996634003188	Walker B; other site
996634003189	D-loop; other site
996634003190	H-loop/switch region; other site
996634003191	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
996634003192	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
996634003193	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
996634003194	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
996634003195	dimer interface [polypeptide binding]; other site
996634003196	ADP-ribose binding site [chemical binding]; other site
996634003197	active site
996634003198	nudix motif; other site
996634003199	metal binding site [ion binding]; metal-binding site
996634003200	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
996634003201	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
996634003202	active site
996634003203	Int/Topo IB signature motif; other site
996634003204	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
996634003205	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996634003206	P-loop; other site
996634003207	Magnesium ion binding site [ion binding]; other site
996634003208	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996634003209	Magnesium ion binding site [ion binding]; other site
996634003210	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996634003211	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
996634003212	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
996634003213	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
996634003214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634003215	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
996634003216	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996634003217	inhibitor-cofactor binding pocket; inhibition site
996634003218	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634003219	catalytic residue [active]
996634003220	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
996634003221	AAA domain; Region: AAA_26; pfam13500
996634003222	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
996634003223	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
996634003224	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634003225	RNA binding surface [nucleotide binding]; other site
996634003226	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
996634003227	active site
996634003228	cytidylate kinase; Provisional; Region: cmk; PRK00023
996634003229	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
996634003230	CMP-binding site; other site
996634003231	The sites determining sugar specificity; other site
996634003232	GTP-binding protein Der; Reviewed; Region: PRK03003
996634003233	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
996634003234	G1 box; other site
996634003235	GTP/Mg2+ binding site [chemical binding]; other site
996634003236	Switch I region; other site
996634003237	G2 box; other site
996634003238	Switch II region; other site
996634003239	G3 box; other site
996634003240	G4 box; other site
996634003241	G5 box; other site
996634003242	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
996634003243	G1 box; other site
996634003244	GTP/Mg2+ binding site [chemical binding]; other site
996634003245	Switch I region; other site
996634003246	G2 box; other site
996634003247	G3 box; other site
996634003248	Switch II region; other site
996634003249	G4 box; other site
996634003250	G5 box; other site
996634003251	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
996634003252	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
996634003253	hypothetical protein; Provisional; Region: PRK08317
996634003254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634003255	S-adenosylmethionine binding site [chemical binding]; other site
996634003256	Predicted esterase [General function prediction only]; Region: COG0627
996634003257	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
996634003258	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
996634003259	siderophore binding site; other site
996634003260	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634003261	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634003262	dimer interface [polypeptide binding]; other site
996634003263	putative PBP binding regions; other site
996634003264	ABC-ATPase subunit  interface; other site
996634003265	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
996634003266	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634003267	ABC-ATPase subunit  interface; other site
996634003268	dimer interface [polypeptide binding]; other site
996634003269	putative PBP binding regions; other site
996634003270	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634003271	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634003272	Walker A/P-loop; other site
996634003273	ATP binding site [chemical binding]; other site
996634003274	Q-loop/lid; other site
996634003275	ABC transporter signature motif; other site
996634003276	Walker B; other site
996634003277	D-loop; other site
996634003278	H-loop/switch region; other site
996634003279	IucA / IucC family; Region: IucA_IucC; pfam04183
996634003280	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
996634003281	IucA / IucC family; Region: IucA_IucC; pfam04183
996634003282	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
996634003283	H+ Antiporter protein; Region: 2A0121; TIGR00900
996634003284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
996634003285	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996634003286	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
996634003287	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
996634003288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996634003289	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
996634003290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634003291	nucleotide binding region [chemical binding]; other site
996634003292	ATP-binding site [chemical binding]; other site
996634003293	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
996634003294	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
996634003295	phosphopeptide binding site; other site
996634003296	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
996634003297	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996634003298	DNA binding residues [nucleotide binding]
996634003299	Bifunctional nuclease; Region: DNase-RNase; pfam02577
996634003300	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
996634003301	DNA binding residues [nucleotide binding]
996634003302	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996634003303	putative dimer interface [polypeptide binding]; other site
996634003304	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
996634003305	metal ion-dependent adhesion site (MIDAS); other site
996634003306	Domain of unknown function DUF21; Region: DUF21; pfam01595
996634003307	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
996634003308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
996634003309	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
996634003310	Domain of unknown function DUF21; Region: DUF21; pfam01595
996634003311	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
996634003312	Transporter associated domain; Region: CorC_HlyC; smart01091
996634003313	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996634003314	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996634003315	ATP binding site [chemical binding]; other site
996634003316	putative Mg++ binding site [ion binding]; other site
996634003317	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634003318	nucleotide binding region [chemical binding]; other site
996634003319	ATP-binding site [chemical binding]; other site
996634003320	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996634003321	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
996634003322	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
996634003323	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996634003324	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
996634003325	CoenzymeA binding site [chemical binding]; other site
996634003326	subunit interaction site [polypeptide binding]; other site
996634003327	PHB binding site; other site
996634003328	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
996634003329	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
996634003330	oligomer interface [polypeptide binding]; other site
996634003331	metal binding site [ion binding]; metal-binding site
996634003332	metal binding site [ion binding]; metal-binding site
996634003333	putative Cl binding site [ion binding]; other site
996634003334	basic sphincter; other site
996634003335	hydrophobic gate; other site
996634003336	periplasmic entrance; other site
996634003337	Methyltransferase domain; Region: Methyltransf_31; pfam13847
996634003338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634003339	S-adenosylmethionine binding site [chemical binding]; other site
996634003340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634003341	ABC transporter signature motif; other site
996634003342	Walker B; other site
996634003343	D-loop; other site
996634003344	H-loop/switch region; other site
996634003345	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
996634003346	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996634003347	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996634003348	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
996634003349	metabolite-proton symporter; Region: 2A0106; TIGR00883
996634003350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634003351	putative substrate translocation pore; other site
996634003352	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
996634003353	FAD binding domain; Region: FAD_binding_4; pfam01565
996634003354	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996634003355	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
996634003356	Cysteine-rich domain; Region: CCG; pfam02754
996634003357	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
996634003358	Sodium Bile acid symporter family; Region: SBF; pfam01758
996634003359	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
996634003360	YceI-like domain; Region: YceI; pfam04264
996634003361	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
996634003362	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
996634003363	Ligand binding site; other site
996634003364	Putative Catalytic site; other site
996634003365	DXD motif; other site
996634003366	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
996634003367	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
996634003368	putative active site [active]
996634003369	catalytic triad [active]
996634003370	putative dimer interface [polypeptide binding]; other site
996634003371	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
996634003372	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
996634003373	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
996634003374	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
996634003375	precorrin-3B synthase; Region: CobG; TIGR02435
996634003376	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
996634003377	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
996634003378	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
996634003379	Precorrin-8X methylmutase; Region: CbiC; pfam02570
996634003380	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
996634003381	active site
996634003382	SAM binding site [chemical binding]; other site
996634003383	homodimer interface [polypeptide binding]; other site
996634003384	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
996634003385	homodimer interface [polypeptide binding]; other site
996634003386	active site
996634003387	SAM binding site [chemical binding]; other site
996634003388	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
996634003389	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
996634003390	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
996634003391	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
996634003392	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
996634003393	active site
996634003394	SAM binding site [chemical binding]; other site
996634003395	homodimer interface [polypeptide binding]; other site
996634003396	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
996634003397	active site
996634003398	putative homodimer interface [polypeptide binding]; other site
996634003399	SAM binding site [chemical binding]; other site
996634003400	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
996634003401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
996634003402	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
996634003403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634003404	NAD(P) binding site [chemical binding]; other site
996634003405	active site
996634003406	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
996634003407	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
996634003408	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
996634003409	active site
996634003410	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996634003411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634003412	ATP binding site [chemical binding]; other site
996634003413	putative Mg++ binding site [ion binding]; other site
996634003414	helicase superfamily c-terminal domain; Region: HELICc; smart00490
996634003415	nucleotide binding region [chemical binding]; other site
996634003416	ATP-binding site [chemical binding]; other site
996634003417	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
996634003418	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
996634003419	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
996634003420	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
996634003421	Predicted transcriptional regulator [Transcription]; Region: COG2378
996634003422	WYL domain; Region: WYL; pfam13280
996634003423	WYL domain; Region: WYL; pfam13280
996634003424	Pup-ligase protein; Region: Pup_ligase; cl15463
996634003425	Pup-like protein; Region: Pup; pfam05639
996634003426	Pup-ligase protein; Region: Pup_ligase; cl15463
996634003427	proteasome ATPase; Region: pup_AAA; TIGR03689
996634003428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634003429	Walker A motif; other site
996634003430	ATP binding site [chemical binding]; other site
996634003431	Walker B motif; other site
996634003432	arginine finger; other site
996634003433	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
996634003434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
996634003435	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
996634003436	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
996634003437	active site
996634003438	metal binding site [ion binding]; metal-binding site
996634003439	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
996634003440	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
996634003441	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
996634003442	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
996634003443	Potassium binding sites [ion binding]; other site
996634003444	Cesium cation binding sites [ion binding]; other site
996634003445	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
996634003446	Aspartase; Region: Aspartase; cd01357
996634003447	active sites [active]
996634003448	tetramer interface [polypeptide binding]; other site
996634003449	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
996634003450	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
996634003451	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
996634003452	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
996634003453	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
996634003454	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
996634003455	homodimer interface [polypeptide binding]; other site
996634003456	putative metal binding site [ion binding]; other site
996634003457	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
996634003458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634003459	motif II; other site
996634003460	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
996634003461	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
996634003462	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
996634003463	substrate binding pocket [chemical binding]; other site
996634003464	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
996634003465	B12 binding site [chemical binding]; other site
996634003466	cobalt ligand [ion binding]; other site
996634003467	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
996634003468	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
996634003469	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634003470	active site
996634003471	HIGH motif; other site
996634003472	nucleotide binding site [chemical binding]; other site
996634003473	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634003474	active site
996634003475	KMSKS motif; other site
996634003476	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
996634003477	tRNA binding surface [nucleotide binding]; other site
996634003478	anticodon binding site; other site
996634003479	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
996634003480	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996634003481	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996634003482	active site
996634003483	catalytic tetrad [active]
996634003484	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
996634003485	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
996634003486	quinone interaction residues [chemical binding]; other site
996634003487	active site
996634003488	catalytic residues [active]
996634003489	FMN binding site [chemical binding]; other site
996634003490	substrate binding site [chemical binding]; other site
996634003491	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
996634003492	substrate binding site [chemical binding]; other site
996634003493	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
996634003494	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
996634003495	dimerization domain swap beta strand [polypeptide binding]; other site
996634003496	regulatory protein interface [polypeptide binding]; other site
996634003497	active site
996634003498	regulatory phosphorylation site [posttranslational modification]; other site
996634003499	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
996634003500	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
996634003501	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
996634003502	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
996634003503	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634003504	Walker A/P-loop; other site
996634003505	ATP binding site [chemical binding]; other site
996634003506	ABC transporter signature motif; other site
996634003507	Walker B; other site
996634003508	D-loop; other site
996634003509	H-loop/switch region; other site
996634003510	ABC transporter; Region: ABC_tran_2; pfam12848
996634003511	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634003512	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
996634003513	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634003514	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634003515	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
996634003516	NAD(P) binding site [chemical binding]; other site
996634003517	active site
996634003518	membrane ATPase/protein kinase; Provisional; Region: PRK09435
996634003519	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
996634003520	Walker A; other site
996634003521	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
996634003522	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
996634003523	active site
996634003524	substrate binding site [chemical binding]; other site
996634003525	coenzyme B12 binding site [chemical binding]; other site
996634003526	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
996634003527	B12 binding site [chemical binding]; other site
996634003528	cobalt ligand [ion binding]; other site
996634003529	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
996634003530	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
996634003531	heterodimer interface [polypeptide binding]; other site
996634003532	substrate interaction site [chemical binding]; other site
996634003533	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
996634003534	Uncharacterized conserved protein [Function unknown]; Region: COG0398
996634003535	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
996634003536	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
996634003537	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
996634003538	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
996634003539	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
996634003540	ferrochelatase; Reviewed; Region: hemH; PRK00035
996634003541	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
996634003542	C-terminal domain interface [polypeptide binding]; other site
996634003543	active site
996634003544	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
996634003545	active site
996634003546	N-terminal domain interface [polypeptide binding]; other site
996634003547	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996634003548	NlpC/P60 family; Region: NLPC_P60; pfam00877
996634003549	aconitate hydratase; Validated; Region: PRK09277
996634003550	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
996634003551	substrate binding site [chemical binding]; other site
996634003552	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
996634003553	ligand binding site [chemical binding]; other site
996634003554	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
996634003555	substrate binding site [chemical binding]; other site
996634003556	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634003557	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634003558	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
996634003559	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
996634003560	catalytic triad [active]
996634003561	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
996634003562	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
996634003563	AAA ATPase domain; Region: AAA_16; pfam13191
996634003564	AAA domain; Region: AAA_22; pfam13401
996634003565	phiCUL0102-III
996634003566	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
996634003567	amidase catalytic site [active]
996634003568	Zn binding residues [ion binding]; other site
996634003569	substrate binding site [chemical binding]; other site
996634003570	Phage-related minor tail protein [Function unknown]; Region: COG5280
996634003571	Phage-related protein [Function unknown]; Region: COG5412
996634003572	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
996634003573	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
996634003574	Clp protease; Region: CLP_protease; pfam00574
996634003575	oligomer interface [polypeptide binding]; other site
996634003576	active site residues [active]
996634003577	large terminase protein; Provisional; Region: 17; PHA02533
996634003578	Phage terminase, small subunit; Region: Terminase_4; cl01525
996634003579	AAA domain; Region: AAA_14; pfam13173
996634003580	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634003581	ATP binding site [chemical binding]; other site
996634003582	putative Mg++ binding site [ion binding]; other site
996634003583	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
996634003584	Virulence-associated protein E; Region: VirE; pfam05272
996634003585	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
996634003586	active site
996634003587	DNA binding site [nucleotide binding]
996634003588	catalytic site [active]
996634003589	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
996634003590	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
996634003591	Helix-turn-helix domain; Region: HTH_17; cl17695
996634003592	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
996634003593	Domain of unknown function (DUF955); Region: DUF955; pfam06114
996634003594	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
996634003595	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996634003596	active site
996634003597	DNA binding site [nucleotide binding]
996634003598	Int/Topo IB signature motif; other site
996634003599	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
996634003600	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634003601	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634003602	Walker A/P-loop; other site
996634003603	ATP binding site [chemical binding]; other site
996634003604	Q-loop/lid; other site
996634003605	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634003606	ABC transporter signature motif; other site
996634003607	Walker B; other site
996634003608	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634003609	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
996634003610	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
996634003611	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
996634003612	trimerization site [polypeptide binding]; other site
996634003613	active site
996634003614	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
996634003615	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
996634003616	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996634003617	catalytic residue [active]
996634003618	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
996634003619	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
996634003620	Walker A/P-loop; other site
996634003621	ATP binding site [chemical binding]; other site
996634003622	Q-loop/lid; other site
996634003623	ABC transporter signature motif; other site
996634003624	Walker B; other site
996634003625	D-loop; other site
996634003626	H-loop/switch region; other site
996634003627	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
996634003628	FeS assembly protein SufD; Region: sufD; TIGR01981
996634003629	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
996634003630	FeS assembly protein SufB; Region: sufB; TIGR01980
996634003631	Predicted transcriptional regulator [Transcription]; Region: COG2345
996634003632	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996634003633	putative DNA binding site [nucleotide binding]; other site
996634003634	putative Zn2+ binding site [ion binding]; other site
996634003635	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
996634003636	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634003637	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996634003638	Walker A/P-loop; other site
996634003639	ATP binding site [chemical binding]; other site
996634003640	Q-loop/lid; other site
996634003641	ABC transporter signature motif; other site
996634003642	Walker B; other site
996634003643	D-loop; other site
996634003644	H-loop/switch region; other site
996634003645	ABC-2 type transporter; Region: ABC2_membrane; cl17235
996634003646	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
996634003647	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
996634003648	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
996634003649	UbiA prenyltransferase family; Region: UbiA; pfam01040
996634003650	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
996634003651	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
996634003652	TPP-binding site [chemical binding]; other site
996634003653	dimer interface [polypeptide binding]; other site
996634003654	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
996634003655	PYR/PP interface [polypeptide binding]; other site
996634003656	dimer interface [polypeptide binding]; other site
996634003657	TPP binding site [chemical binding]; other site
996634003658	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
996634003659	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
996634003660	putative active site [active]
996634003661	transaldolase; Provisional; Region: PRK03903
996634003662	catalytic residue [active]
996634003663	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
996634003664	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
996634003665	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
996634003666	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
996634003667	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
996634003668	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
996634003669	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
996634003670	putative active site [active]
996634003671	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
996634003672	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
996634003673	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
996634003674	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
996634003675	triosephosphate isomerase; Provisional; Region: PRK14567
996634003676	substrate binding site [chemical binding]; other site
996634003677	dimer interface [polypeptide binding]; other site
996634003678	catalytic triad [active]
996634003679	Phosphoglycerate kinase; Region: PGK; pfam00162
996634003680	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
996634003681	substrate binding site [chemical binding]; other site
996634003682	hinge regions; other site
996634003683	ADP binding site [chemical binding]; other site
996634003684	catalytic site [active]
996634003685	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
996634003686	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
996634003687	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
996634003688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
996634003689	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
996634003690	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
996634003691	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
996634003692	phosphate binding site [ion binding]; other site
996634003693	putative substrate binding pocket [chemical binding]; other site
996634003694	dimer interface [polypeptide binding]; other site
996634003695	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
996634003696	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
996634003697	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
996634003698	GIY-YIG motif/motif A; other site
996634003699	active site
996634003700	catalytic site [active]
996634003701	putative DNA binding site [nucleotide binding]; other site
996634003702	metal binding site [ion binding]; metal-binding site
996634003703	UvrB/uvrC motif; Region: UVR; pfam02151
996634003704	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
996634003705	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
996634003706	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
996634003707	homopentamer interface [polypeptide binding]; other site
996634003708	active site
996634003709	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
996634003710	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
996634003711	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
996634003712	dimerization interface [polypeptide binding]; other site
996634003713	active site
996634003714	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
996634003715	Lumazine binding domain; Region: Lum_binding; pfam00677
996634003716	Lumazine binding domain; Region: Lum_binding; pfam00677
996634003717	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
996634003718	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
996634003719	catalytic motif [active]
996634003720	Zn binding site [ion binding]; other site
996634003721	RibD C-terminal domain; Region: RibD_C; pfam01872
996634003722	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
996634003723	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
996634003724	substrate binding site [chemical binding]; other site
996634003725	hexamer interface [polypeptide binding]; other site
996634003726	metal binding site [ion binding]; metal-binding site
996634003727	16S rRNA methyltransferase B; Provisional; Region: PRK14902
996634003728	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
996634003729	putative RNA binding site [nucleotide binding]; other site
996634003730	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
996634003731	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
996634003732	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
996634003733	putative active site [active]
996634003734	substrate binding site [chemical binding]; other site
996634003735	putative cosubstrate binding site; other site
996634003736	catalytic site [active]
996634003737	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
996634003738	substrate binding site [chemical binding]; other site
996634003739	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
996634003740	active site
996634003741	catalytic residues [active]
996634003742	metal binding site [ion binding]; metal-binding site
996634003743	primosome assembly protein PriA; Provisional; Region: PRK14873
996634003744	S-adenosylmethionine synthetase; Validated; Region: PRK05250
996634003745	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
996634003746	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
996634003747	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
996634003748	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
996634003749	Flavoprotein; Region: Flavoprotein; pfam02441
996634003750	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
996634003751	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
996634003752	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
996634003753	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
996634003754	catalytic site [active]
996634003755	G-X2-G-X-G-K; other site
996634003756	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
996634003757	active site
996634003758	dimer interface [polypeptide binding]; other site
996634003759	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
996634003760	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996634003761	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996634003762	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
996634003763	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996634003764	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996634003765	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
996634003766	IMP binding site; other site
996634003767	dimer interface [polypeptide binding]; other site
996634003768	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
996634003769	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
996634003770	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
996634003771	catalytic site [active]
996634003772	subunit interface [polypeptide binding]; other site
996634003773	dihydroorotase; Validated; Region: pyrC; PRK09357
996634003774	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
996634003775	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
996634003776	active site
996634003777	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
996634003778	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
996634003779	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
996634003780	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
996634003781	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634003782	active site
996634003783	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
996634003784	hydrophobic ligand binding site; other site
996634003785	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634003786	TIGR01777 family protein; Region: yfcH
996634003787	NAD(P) binding site [chemical binding]; other site
996634003788	active site
996634003789	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
996634003790	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
996634003791	putative RNA binding site [nucleotide binding]; other site
996634003792	elongation factor P; Validated; Region: PRK00529
996634003793	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
996634003794	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
996634003795	RNA binding site [nucleotide binding]; other site
996634003796	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
996634003797	RNA binding site [nucleotide binding]; other site
996634003798	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
996634003799	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
996634003800	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
996634003801	active site
996634003802	Dehydroquinase class II; Region: DHquinase_II; pfam01220
996634003803	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
996634003804	trimer interface [polypeptide binding]; other site
996634003805	active site
996634003806	dimer interface [polypeptide binding]; other site
996634003807	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
996634003808	active site
996634003809	dimer interface [polypeptide binding]; other site
996634003810	metal binding site [ion binding]; metal-binding site
996634003811	shikimate kinase; Reviewed; Region: aroK; PRK00131
996634003812	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
996634003813	ADP binding site [chemical binding]; other site
996634003814	magnesium binding site [ion binding]; other site
996634003815	putative shikimate binding site; other site
996634003816	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
996634003817	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
996634003818	Tetramer interface [polypeptide binding]; other site
996634003819	active site
996634003820	FMN-binding site [chemical binding]; other site
996634003821	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
996634003822	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
996634003823	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
996634003824	shikimate binding site; other site
996634003825	NAD(P) binding site [chemical binding]; other site
996634003826	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
996634003827	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
996634003828	dimerization interface [polypeptide binding]; other site
996634003829	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
996634003830	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
996634003831	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
996634003832	motif 1; other site
996634003833	active site
996634003834	motif 2; other site
996634003835	motif 3; other site
996634003836	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
996634003837	DHHA1 domain; Region: DHHA1; pfam02272
996634003838	recombination factor protein RarA; Reviewed; Region: PRK13342
996634003839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634003840	Walker A motif; other site
996634003841	ATP binding site [chemical binding]; other site
996634003842	Walker B motif; other site
996634003843	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
996634003844	Phosphotransferase enzyme family; Region: APH; pfam01636
996634003845	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
996634003846	substrate binding site [chemical binding]; other site
996634003847	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
996634003848	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
996634003849	dimer interface [polypeptide binding]; other site
996634003850	anticodon binding site; other site
996634003851	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
996634003852	homodimer interface [polypeptide binding]; other site
996634003853	motif 1; other site
996634003854	active site
996634003855	motif 2; other site
996634003856	GAD domain; Region: GAD; pfam02938
996634003857	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996634003858	active site
996634003859	motif 3; other site
996634003860	Predicted metalloprotease [General function prediction only]; Region: COG2321
996634003861	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
996634003862	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996634003863	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634003864	ATP binding site [chemical binding]; other site
996634003865	putative Mg++ binding site [ion binding]; other site
996634003866	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634003867	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
996634003868	nucleotide binding region [chemical binding]; other site
996634003869	ATP-binding site [chemical binding]; other site
996634003870	Predicted membrane protein [Function unknown]; Region: COG1511
996634003871	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
996634003872	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
996634003873	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
996634003874	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
996634003875	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
996634003876	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
996634003877	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634003878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634003879	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996634003880	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
996634003881	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
996634003882	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
996634003883	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
996634003884	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
996634003885	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
996634003886	dimer interface [polypeptide binding]; other site
996634003887	motif 1; other site
996634003888	active site
996634003889	motif 2; other site
996634003890	motif 3; other site
996634003891	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
996634003892	anticodon binding site; other site
996634003893	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
996634003894	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
996634003895	dimer interface [polypeptide binding]; other site
996634003896	catalytic triad [active]
996634003897	peroxidatic and resolving cysteines [active]
996634003898	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
996634003899	active site
996634003900	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
996634003901	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996634003902	Zn2+ binding site [ion binding]; other site
996634003903	Mg2+ binding site [ion binding]; other site
996634003904	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
996634003905	synthetase active site [active]
996634003906	NTP binding site [chemical binding]; other site
996634003907	metal binding site [ion binding]; metal-binding site
996634003908	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
996634003909	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
996634003910	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634003911	active site
996634003912	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
996634003913	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
996634003914	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
996634003915	Protein export membrane protein; Region: SecD_SecF; pfam02355
996634003916	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
996634003917	Protein export membrane protein; Region: SecD_SecF; cl14618
996634003918	Preprotein translocase subunit; Region: YajC; pfam02699
996634003919	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
996634003920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634003921	Walker A motif; other site
996634003922	ATP binding site [chemical binding]; other site
996634003923	Walker B motif; other site
996634003924	arginine finger; other site
996634003925	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
996634003926	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
996634003927	RuvA N terminal domain; Region: RuvA_N; pfam01330
996634003928	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
996634003929	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
996634003930	active site
996634003931	putative DNA-binding cleft [nucleotide binding]; other site
996634003932	dimer interface [polypeptide binding]; other site
996634003933	hypothetical protein; Validated; Region: PRK00110
996634003934	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
996634003935	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
996634003936	active site
996634003937	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
996634003938	catalytic triad [active]
996634003939	dimer interface [polypeptide binding]; other site
996634003940	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
996634003941	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
996634003942	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
996634003943	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996634003944	catalytic residue [active]
996634003945	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996634003946	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
996634003947	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
996634003948	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
996634003949	putative acyl-acceptor binding pocket; other site
996634003950	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
996634003951	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
996634003952	nucleotide binding site/active site [active]
996634003953	HIT family signature motif; other site
996634003954	catalytic residue [active]
996634003955	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
996634003956	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
996634003957	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
996634003958	active site
996634003959	dimer interface [polypeptide binding]; other site
996634003960	motif 1; other site
996634003961	motif 2; other site
996634003962	motif 3; other site
996634003963	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
996634003964	anticodon binding site; other site
996634003965	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
996634003966	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
996634003967	Protein of unknown function (DUF461); Region: DUF461; pfam04314
996634003968	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
996634003969	hypothetical protein; Provisional; Region: PRK14059
996634003970	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
996634003971	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
996634003972	SelR domain; Region: SelR; pfam01641
996634003973	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
996634003974	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
996634003975	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
996634003976	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
996634003977	catalytic site [active]
996634003978	putative active site [active]
996634003979	putative substrate binding site [chemical binding]; other site
996634003980	HRDC domain; Region: HRDC; pfam00570
996634003981	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
996634003982	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
996634003983	TPP-binding site; other site
996634003984	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
996634003985	PYR/PP interface [polypeptide binding]; other site
996634003986	dimer interface [polypeptide binding]; other site
996634003987	TPP binding site [chemical binding]; other site
996634003988	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
996634003989	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
996634003990	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
996634003991	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
996634003992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634003993	S-adenosylmethionine binding site [chemical binding]; other site
996634003994	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
996634003995	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
996634003996	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
996634003997	trimer interface [polypeptide binding]; other site
996634003998	active site
996634003999	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
996634004000	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
996634004001	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996634004002	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
996634004003	active site
996634004004	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
996634004005	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
996634004006	nucleotide binding site [chemical binding]; other site
996634004007	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
996634004008	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
996634004009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634004010	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
996634004011	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634004012	DNA binding residues [nucleotide binding]
996634004013	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
996634004014	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634004015	ATP binding site [chemical binding]; other site
996634004016	putative Mg++ binding site [ion binding]; other site
996634004017	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
996634004018	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
996634004019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634004020	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
996634004021	S-adenosylmethionine binding site [chemical binding]; other site
996634004022	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
996634004023	putative active site [active]
996634004024	dimerization interface [polypeptide binding]; other site
996634004025	putative tRNAtyr binding site [nucleotide binding]; other site
996634004026	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
996634004027	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
996634004028	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634004029	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
996634004030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634004031	DNA binding residues [nucleotide binding]
996634004032	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
996634004033	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
996634004034	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
996634004035	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
996634004036	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
996634004037	NAD binding site [chemical binding]; other site
996634004038	homodimer interface [polypeptide binding]; other site
996634004039	active site
996634004040	substrate binding site [chemical binding]; other site
996634004041	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
996634004042	PAC2 family; Region: PAC2; pfam09754
996634004043	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996634004044	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634004045	ATP binding site [chemical binding]; other site
996634004046	putative Mg++ binding site [ion binding]; other site
996634004047	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634004048	nucleotide binding region [chemical binding]; other site
996634004049	ATP-binding site [chemical binding]; other site
996634004050	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
996634004051	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
996634004052	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
996634004053	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
996634004054	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
996634004055	dimer interface [polypeptide binding]; other site
996634004056	decamer (pentamer of dimers) interface [polypeptide binding]; other site
996634004057	catalytic triad [active]
996634004058	peroxidatic and resolving cysteines [active]
996634004059	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996634004060	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
996634004061	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
996634004062	dimerization interface [polypeptide binding]; other site
996634004063	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
996634004064	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
996634004065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996634004066	ATP binding site [chemical binding]; other site
996634004067	putative Mg++ binding site [ion binding]; other site
996634004068	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996634004069	nucleotide binding region [chemical binding]; other site
996634004070	ATP-binding site [chemical binding]; other site
996634004071	Helicase associated domain (HA2); Region: HA2; pfam04408
996634004072	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
996634004073	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
996634004074	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
996634004075	ATP cone domain; Region: ATP-cone; pfam03477
996634004076	LexA repressor; Validated; Region: PRK00215
996634004077	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
996634004078	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
996634004079	Catalytic site [active]
996634004080	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
996634004081	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
996634004082	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
996634004083	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
996634004084	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
996634004085	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
996634004086	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
996634004087	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
996634004088	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
996634004089	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
996634004090	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
996634004091	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
996634004092	putative substrate binding site [chemical binding]; other site
996634004093	putative ATP binding site [chemical binding]; other site
996634004094	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
996634004095	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
996634004096	active site
996634004097	phosphorylation site [posttranslational modification]
996634004098	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
996634004099	active site
996634004100	P-loop; other site
996634004101	phosphorylation site [posttranslational modification]
996634004102	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
996634004103	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
996634004104	dimerization domain swap beta strand [polypeptide binding]; other site
996634004105	regulatory protein interface [polypeptide binding]; other site
996634004106	active site
996634004107	regulatory phosphorylation site [posttranslational modification]; other site
996634004108	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
996634004109	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
996634004110	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
996634004111	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996634004112	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
996634004113	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
996634004114	GTPases [General function prediction only]; Region: HflX; COG2262
996634004115	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
996634004116	HflX GTPase family; Region: HflX; cd01878
996634004117	G1 box; other site
996634004118	GTP/Mg2+ binding site [chemical binding]; other site
996634004119	Switch I region; other site
996634004120	G2 box; other site
996634004121	G3 box; other site
996634004122	Switch II region; other site
996634004123	G4 box; other site
996634004124	G5 box; other site
996634004125	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
996634004126	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
996634004127	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
996634004128	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
996634004129	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
996634004130	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
996634004131	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
996634004132	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
996634004133	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
996634004134	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
996634004135	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
996634004136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634004137	FeS/SAM binding site; other site
996634004138	recombination regulator RecX; Reviewed; Region: recX; PRK00117
996634004139	recombinase A; Provisional; Region: recA; PRK09354
996634004140	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
996634004141	hexamer interface [polypeptide binding]; other site
996634004142	Walker A motif; other site
996634004143	ATP binding site [chemical binding]; other site
996634004144	Walker B motif; other site
996634004145	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
996634004146	BioY family; Region: BioY; pfam02632
996634004147	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
996634004148	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
996634004149	Walker A/P-loop; other site
996634004150	ATP binding site [chemical binding]; other site
996634004151	Q-loop/lid; other site
996634004152	ABC transporter signature motif; other site
996634004153	Walker B; other site
996634004154	D-loop; other site
996634004155	H-loop/switch region; other site
996634004156	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
996634004157	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
996634004158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996634004159	sequence-specific DNA binding site [nucleotide binding]; other site
996634004160	salt bridge; other site
996634004161	Competence-damaged protein; Region: CinA; pfam02464
996634004162	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
996634004163	YCII-related domain; Region: YCII; cl00999
996634004164	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
996634004165	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
996634004166	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
996634004167	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
996634004168	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
996634004169	TIGR03085 family protein; Region: TIGR03085
996634004170	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
996634004171	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996634004172	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
996634004173	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
996634004174	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
996634004175	dimer interface [polypeptide binding]; other site
996634004176	active site
996634004177	catalytic residue [active]
996634004178	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
996634004179	dihydrodipicolinate reductase; Provisional; Region: PRK00048
996634004180	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
996634004181	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
996634004182	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
996634004183	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
996634004184	oligomer interface [polypeptide binding]; other site
996634004185	RNA binding site [nucleotide binding]; other site
996634004186	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
996634004187	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
996634004188	RNase E interface [polypeptide binding]; other site
996634004189	trimer interface [polypeptide binding]; other site
996634004190	active site
996634004191	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
996634004192	putative nucleic acid binding region [nucleotide binding]; other site
996634004193	G-X-X-G motif; other site
996634004194	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
996634004195	RNA binding site [nucleotide binding]; other site
996634004196	domain interface; other site
996634004197	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
996634004198	16S/18S rRNA binding site [nucleotide binding]; other site
996634004199	S13e-L30e interaction site [polypeptide binding]; other site
996634004200	25S rRNA binding site [nucleotide binding]; other site
996634004201	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
996634004202	active site
996634004203	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
996634004204	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
996634004205	active site
996634004206	Riboflavin kinase; Region: Flavokinase; smart00904
996634004207	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
996634004208	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
996634004209	RNA binding site [nucleotide binding]; other site
996634004210	active site
996634004211	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
996634004212	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
996634004213	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
996634004214	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
996634004215	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
996634004216	active site
996634004217	metal binding site [ion binding]; metal-binding site
996634004218	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
996634004219	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
996634004220	DHH family; Region: DHH; pfam01368
996634004221	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
996634004222	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
996634004223	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
996634004224	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
996634004225	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
996634004226	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
996634004227	G1 box; other site
996634004228	putative GEF interaction site [polypeptide binding]; other site
996634004229	GTP/Mg2+ binding site [chemical binding]; other site
996634004230	Switch I region; other site
996634004231	G2 box; other site
996634004232	G3 box; other site
996634004233	Switch II region; other site
996634004234	G4 box; other site
996634004235	G5 box; other site
996634004236	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
996634004237	Translation-initiation factor 2; Region: IF-2; pfam11987
996634004238	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
996634004239	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
996634004240	putative RNA binding cleft [nucleotide binding]; other site
996634004241	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
996634004242	NusA N-terminal domain; Region: NusA_N; pfam08529
996634004243	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
996634004244	RNA binding site [nucleotide binding]; other site
996634004245	homodimer interface [polypeptide binding]; other site
996634004246	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
996634004247	G-X-X-G motif; other site
996634004248	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
996634004249	G-X-X-G motif; other site
996634004250	ribosome maturation protein RimP; Reviewed; Region: PRK00092
996634004251	Sm and related proteins; Region: Sm_like; cl00259
996634004252	heptamer interface [polypeptide binding]; other site
996634004253	Sm1 motif; other site
996634004254	hexamer interface [polypeptide binding]; other site
996634004255	RNA binding site [nucleotide binding]; other site
996634004256	Sm2 motif; other site
996634004257	prolyl-tRNA synthetase; Provisional; Region: PRK09194
996634004258	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
996634004259	dimer interface [polypeptide binding]; other site
996634004260	motif 1; other site
996634004261	active site
996634004262	motif 2; other site
996634004263	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
996634004264	putative deacylase active site [active]
996634004265	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996634004266	active site
996634004267	motif 3; other site
996634004268	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
996634004269	anticodon binding site; other site
996634004270	hypothetical protein; Validated; Region: PRK02101
996634004271	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
996634004272	active site
996634004273	SAM binding site [chemical binding]; other site
996634004274	homodimer interface [polypeptide binding]; other site
996634004275	Uncharacterized conserved protein [Function unknown]; Region: COG0397
996634004276	hypothetical protein; Validated; Region: PRK00029
996634004277	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
996634004278	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
996634004279	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
996634004280	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
996634004281	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
996634004282	DNA binding site [nucleotide binding]
996634004283	active site
996634004284	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
996634004285	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
996634004286	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
996634004287	catalytic triad [active]
996634004288	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
996634004289	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
996634004290	Walker A motif; other site
996634004291	homodimer interface [polypeptide binding]; other site
996634004292	ATP binding site [chemical binding]; other site
996634004293	hydroxycobalamin binding site [chemical binding]; other site
996634004294	Walker B motif; other site
996634004295	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
996634004296	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
996634004297	metal ion-dependent adhesion site (MIDAS); other site
996634004298	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
996634004299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634004300	Walker A motif; other site
996634004301	ATP binding site [chemical binding]; other site
996634004302	Walker B motif; other site
996634004303	arginine finger; other site
996634004304	malate:quinone oxidoreductase; Validated; Region: PRK05257
996634004305	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
996634004306	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
996634004307	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
996634004308	mycothione reductase; Reviewed; Region: PRK07846
996634004309	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996634004310	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996634004311	cobyric acid synthase; Provisional; Region: PRK00784
996634004312	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
996634004313	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
996634004314	catalytic triad [active]
996634004315	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
996634004316	active site
996634004317	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
996634004318	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
996634004319	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
996634004320	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
996634004321	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
996634004322	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
996634004323	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
996634004324	active site
996634004325	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
996634004326	protein binding site [polypeptide binding]; other site
996634004327	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
996634004328	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
996634004329	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
996634004330	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
996634004331	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
996634004332	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
996634004333	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
996634004334	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634004335	FeS/SAM binding site; other site
996634004336	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
996634004337	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
996634004338	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
996634004339	ribosome recycling factor; Reviewed; Region: frr; PRK00083
996634004340	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
996634004341	hinge region; other site
996634004342	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
996634004343	putative nucleotide binding site [chemical binding]; other site
996634004344	uridine monophosphate binding site [chemical binding]; other site
996634004345	homohexameric interface [polypeptide binding]; other site
996634004346	elongation factor Ts; Provisional; Region: tsf; PRK09377
996634004347	UBA/TS-N domain; Region: UBA; pfam00627
996634004348	Elongation factor TS; Region: EF_TS; pfam00889
996634004349	Elongation factor TS; Region: EF_TS; pfam00889
996634004350	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
996634004351	rRNA interaction site [nucleotide binding]; other site
996634004352	S8 interaction site; other site
996634004353	putative laminin-1 binding site; other site
996634004354	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
996634004355	Peptidase family M23; Region: Peptidase_M23; pfam01551
996634004356	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
996634004357	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996634004358	active site
996634004359	DNA binding site [nucleotide binding]
996634004360	Int/Topo IB signature motif; other site
996634004361	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
996634004362	DNA protecting protein DprA; Region: dprA; TIGR00732
996634004363	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
996634004364	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
996634004365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634004366	Walker A motif; other site
996634004367	ATP binding site [chemical binding]; other site
996634004368	Walker B motif; other site
996634004369	arginine finger; other site
996634004370	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
996634004371	hypothetical protein; Reviewed; Region: PRK12497
996634004372	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
996634004373	ThiC-associated domain; Region: ThiC-associated; pfam13667
996634004374	ThiC family; Region: ThiC; pfam01964
996634004375	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
996634004376	thiamine phosphate binding site [chemical binding]; other site
996634004377	active site
996634004378	pyrophosphate binding site [ion binding]; other site
996634004379	hydroxyglutarate oxidase; Provisional; Region: PRK11728
996634004380	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
996634004381	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
996634004382	thiS-thiF/thiG interaction site; other site
996634004383	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
996634004384	ThiS interaction site; other site
996634004385	putative active site [active]
996634004386	tetramer interface [polypeptide binding]; other site
996634004387	thiamine biosynthesis protein ThiF; Validated; Region: PRK05600
996634004388	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
996634004389	ATP binding site [chemical binding]; other site
996634004390	substrate interface [chemical binding]; other site
996634004391	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
996634004392	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
996634004393	dimer interface [polypeptide binding]; other site
996634004394	substrate binding site [chemical binding]; other site
996634004395	ATP binding site [chemical binding]; other site
996634004396	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
996634004397	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
996634004398	RNA/DNA hybrid binding site [nucleotide binding]; other site
996634004399	active site
996634004400	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
996634004401	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
996634004402	Catalytic site [active]
996634004403	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
996634004404	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
996634004405	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
996634004406	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
996634004407	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
996634004408	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
996634004409	RNA binding site [nucleotide binding]; other site
996634004410	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
996634004411	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
996634004412	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
996634004413	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
996634004414	active site
996634004415	phosphorylation site [posttranslational modification]
996634004416	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
996634004417	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
996634004418	RimM N-terminal domain; Region: RimM; pfam01782
996634004419	PRC-barrel domain; Region: PRC; pfam05239
996634004420	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
996634004421	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
996634004422	signal recognition particle protein; Provisional; Region: PRK10867
996634004423	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
996634004424	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
996634004425	P loop; other site
996634004426	GTP binding site [chemical binding]; other site
996634004427	Signal peptide binding domain; Region: SRP_SPB; pfam02978
996634004428	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
996634004429	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996634004430	metal binding triad; other site
996634004431	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
996634004432	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996634004433	Zn2+ binding site [ion binding]; other site
996634004434	Mg2+ binding site [ion binding]; other site
996634004435	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
996634004436	Nitrogen regulatory protein P-II; Region: P-II; smart00938
996634004437	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
996634004438	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
996634004439	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996634004440	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
996634004441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634004442	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
996634004443	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
996634004444	ABC transporter signature motif; other site
996634004445	Walker B; other site
996634004446	D-loop; other site
996634004447	H-loop/switch region; other site
996634004448	Acylphosphatase; Region: Acylphosphatase; cl00551
996634004449	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
996634004450	amino acid carrier protein; Region: agcS; TIGR00835
996634004451	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
996634004452	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
996634004453	DNA binding site [nucleotide binding]
996634004454	catalytic residue [active]
996634004455	H2TH interface [polypeptide binding]; other site
996634004456	putative catalytic residues [active]
996634004457	turnover-facilitating residue; other site
996634004458	intercalation triad [nucleotide binding]; other site
996634004459	8OG recognition residue [nucleotide binding]; other site
996634004460	putative reading head residues; other site
996634004461	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
996634004462	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
996634004463	ribonuclease III; Reviewed; Region: rnc; PRK00102
996634004464	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
996634004465	dimerization interface [polypeptide binding]; other site
996634004466	active site
996634004467	metal binding site [ion binding]; metal-binding site
996634004468	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
996634004469	dsRNA binding site [nucleotide binding]; other site
996634004470	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
996634004471	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
996634004472	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
996634004473	RibD C-terminal domain; Region: RibD_C; cl17279
996634004474	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
996634004475	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
996634004476	hexamer interface [polypeptide binding]; other site
996634004477	ligand binding site [chemical binding]; other site
996634004478	putative active site [active]
996634004479	NAD(P) binding site [chemical binding]; other site
996634004480	glutamate dehydrogenase; Provisional; Region: PRK09414
996634004481	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
996634004482	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
996634004483	NAD(P) binding site [chemical binding]; other site
996634004484	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
996634004485	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
996634004486	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
996634004487	nucleotide binding site/active site [active]
996634004488	HIT family signature motif; other site
996634004489	catalytic residue [active]
996634004490	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
996634004491	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
996634004492	metal binding site [ion binding]; metal-binding site
996634004493	putative dimer interface [polypeptide binding]; other site
996634004494	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
996634004495	homodimer interface [polypeptide binding]; other site
996634004496	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
996634004497	active site pocket [active]
996634004498	Electron transfer DM13; Region: DM13; pfam10517
996634004499	pyruvate kinase; Provisional; Region: PRK06247
996634004500	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
996634004501	domain interfaces; other site
996634004502	active site
996634004503	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
996634004504	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
996634004505	active site
996634004506	ribulose/triose binding site [chemical binding]; other site
996634004507	phosphate binding site [ion binding]; other site
996634004508	substrate (anthranilate) binding pocket [chemical binding]; other site
996634004509	product (indole) binding pocket [chemical binding]; other site
996634004510	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
996634004511	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
996634004512	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
996634004513	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
996634004514	substrate binding site [chemical binding]; other site
996634004515	glutamase interaction surface [polypeptide binding]; other site
996634004516	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
996634004517	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996634004518	active site
996634004519	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
996634004520	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
996634004521	catalytic residues [active]
996634004522	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
996634004523	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
996634004524	putative active site [active]
996634004525	oxyanion strand; other site
996634004526	catalytic triad [active]
996634004527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634004528	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
996634004529	putative active site pocket [active]
996634004530	4-fold oligomerization interface [polypeptide binding]; other site
996634004531	metal binding residues [ion binding]; metal-binding site
996634004532	3-fold/trimer interface [polypeptide binding]; other site
996634004533	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
996634004534	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634004535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634004536	homodimer interface [polypeptide binding]; other site
996634004537	catalytic residue [active]
996634004538	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
996634004539	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
996634004540	NAD binding site [chemical binding]; other site
996634004541	dimerization interface [polypeptide binding]; other site
996634004542	product binding site; other site
996634004543	substrate binding site [chemical binding]; other site
996634004544	zinc binding site [ion binding]; other site
996634004545	catalytic residues [active]
996634004546	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
996634004547	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
996634004548	tetracycline repressor protein TetR; Provisional; Region: PRK13756
996634004549	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634004550	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
996634004551	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
996634004552	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
996634004553	active site
996634004554	catalytic site [active]
996634004555	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
996634004556	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
996634004557	active site
996634004558	catalytic site [active]
996634004559	substrate binding site [chemical binding]; other site
996634004560	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
996634004561	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
996634004562	synthetase active site [active]
996634004563	NTP binding site [chemical binding]; other site
996634004564	metal binding site [ion binding]; metal-binding site
996634004565	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634004566	RNA binding surface [nucleotide binding]; other site
996634004567	Uncharacterized conserved protein [Function unknown]; Region: COG1739
996634004568	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
996634004569	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
996634004570	threonine dehydratase; Validated; Region: PRK08639
996634004571	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
996634004572	tetramer interface [polypeptide binding]; other site
996634004573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634004574	catalytic residue [active]
996634004575	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
996634004576	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
996634004577	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
996634004578	active site
996634004579	PHP Thumb interface [polypeptide binding]; other site
996634004580	metal binding site [ion binding]; metal-binding site
996634004581	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
996634004582	generic binding surface I; other site
996634004583	generic binding surface II; other site
996634004584	Predicted permeases [General function prediction only]; Region: RarD; COG2962
996634004585	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
996634004586	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996634004587	RNA binding surface [nucleotide binding]; other site
996634004588	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
996634004589	active site
996634004590	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
996634004591	lipoprotein signal peptidase; Provisional; Region: PRK14787
996634004592	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
996634004593	active site
996634004594	homotetramer interface [polypeptide binding]; other site
996634004595	homodimer interface [polypeptide binding]; other site
996634004596	DNA polymerase IV; Provisional; Region: PRK03348
996634004597	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
996634004598	active site
996634004599	DNA binding site [nucleotide binding]
996634004600	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
996634004601	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
996634004602	HIGH motif; other site
996634004603	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
996634004604	active site
996634004605	KMSKS motif; other site
996634004606	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
996634004607	tRNA binding surface [nucleotide binding]; other site
996634004608	anticodon binding site; other site
996634004609	DivIVA domain; Region: DivI1A_domain; TIGR03544
996634004610	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
996634004611	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
996634004612	YGGT family; Region: YGGT; cl00508
996634004613	Protein of unknown function (DUF552); Region: DUF552; cl00775
996634004614	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
996634004615	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
996634004616	cell division protein FtsZ; Validated; Region: PRK09330
996634004617	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
996634004618	nucleotide binding site [chemical binding]; other site
996634004619	SulA interaction site; other site
996634004620	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
996634004621	Cell division protein FtsQ; Region: FtsQ; pfam03799
996634004622	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
996634004623	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
996634004624	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996634004625	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996634004626	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
996634004627	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
996634004628	homodimer interface [polypeptide binding]; other site
996634004629	active site
996634004630	cell division protein FtsW; Region: ftsW; TIGR02614
996634004631	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
996634004632	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996634004633	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
996634004634	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
996634004635	Mg++ binding site [ion binding]; other site
996634004636	putative catalytic motif [active]
996634004637	putative substrate binding site [chemical binding]; other site
996634004638	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
996634004639	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
996634004640	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996634004641	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996634004642	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
996634004643	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996634004644	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996634004645	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
996634004646	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
996634004647	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
996634004648	Septum formation initiator; Region: DivIC; cl17659
996634004649	MraW methylase family; Region: Methyltransf_5; cl17771
996634004650	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
996634004651	cell division protein MraZ; Reviewed; Region: PRK00326
996634004652	MraZ protein; Region: MraZ; pfam02381
996634004653	MraZ protein; Region: MraZ; pfam02381
996634004654	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
996634004655	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
996634004656	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
996634004657	Coenzyme A binding pocket [chemical binding]; other site
996634004658	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
996634004659	FAD binding site [chemical binding]; other site
996634004660	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
996634004661	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
996634004662	substrate binding pocket [chemical binding]; other site
996634004663	chain length determination region; other site
996634004664	substrate-Mg2+ binding site; other site
996634004665	catalytic residues [active]
996634004666	aspartate-rich region 1; other site
996634004667	active site lid residues [active]
996634004668	aspartate-rich region 2; other site
996634004669	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
996634004670	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996634004671	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996634004672	active site
996634004673	ATP binding site [chemical binding]; other site
996634004674	substrate binding site [chemical binding]; other site
996634004675	activation loop (A-loop); other site
996634004676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
996634004677	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634004678	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634004679	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634004680	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634004681	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
996634004682	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
996634004683	Predicted membrane protein [Function unknown]; Region: COG4763
996634004684	Acyltransferase family; Region: Acyl_transf_3; pfam01757
996634004685	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
996634004686	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
996634004687	putative acyl-acceptor binding pocket; other site
996634004688	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
996634004689	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
996634004690	nucleotide binding site [chemical binding]; other site
996634004691	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
996634004692	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996634004693	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
996634004694	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996634004695	NlpC/P60 family; Region: NLPC_P60; pfam00877
996634004696	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996634004697	NlpC/P60 family; Region: NLPC_P60; pfam00877
996634004698	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
996634004699	heme bH binding site [chemical binding]; other site
996634004700	intrachain domain interface; other site
996634004701	heme bL binding site [chemical binding]; other site
996634004702	interchain domain interface [polypeptide binding]; other site
996634004703	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
996634004704	Qo binding site; other site
996634004705	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
996634004706	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
996634004707	iron-sulfur cluster [ion binding]; other site
996634004708	[2Fe-2S] cluster binding site [ion binding]; other site
996634004709	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996634004710	Cytochrome c; Region: Cytochrom_C; pfam00034
996634004711	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996634004712	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
996634004713	Subunit I/III interface [polypeptide binding]; other site
996634004714	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
996634004715	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
996634004716	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
996634004717	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
996634004718	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
996634004719	active site
996634004720	dimer interface [polypeptide binding]; other site
996634004721	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
996634004722	Ligand Binding Site [chemical binding]; other site
996634004723	Molecular Tunnel; other site
996634004724	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
996634004725	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
996634004726	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
996634004727	homotrimer interface [polypeptide binding]; other site
996634004728	Walker A motif; other site
996634004729	GTP binding site [chemical binding]; other site
996634004730	Walker B motif; other site
996634004731	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
996634004732	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
996634004733	putative dimer interface [polypeptide binding]; other site
996634004734	active site pocket [active]
996634004735	putative cataytic base [active]
996634004736	cobalamin synthase; Reviewed; Region: cobS; PRK00235
996634004737	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
996634004738	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
996634004739	homodimer interface [polypeptide binding]; other site
996634004740	substrate-cofactor binding pocket; other site
996634004741	catalytic residue [active]
996634004742	multifunctional aminopeptidase A; Provisional; Region: PRK00913
996634004743	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
996634004744	interface (dimer of trimers) [polypeptide binding]; other site
996634004745	Substrate-binding/catalytic site; other site
996634004746	Zn-binding sites [ion binding]; other site
996634004747	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
996634004748	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996634004749	E3 interaction surface; other site
996634004750	lipoyl attachment site [posttranslational modification]; other site
996634004751	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996634004752	E3 interaction surface; other site
996634004753	lipoyl attachment site [posttranslational modification]; other site
996634004754	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996634004755	E3 interaction surface; other site
996634004756	lipoyl attachment site [posttranslational modification]; other site
996634004757	e3 binding domain; Region: E3_binding; pfam02817
996634004758	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
996634004759	glycine dehydrogenase; Provisional; Region: PRK05367
996634004760	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
996634004761	tetramer interface [polypeptide binding]; other site
996634004762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634004763	catalytic residue [active]
996634004764	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
996634004765	tetramer interface [polypeptide binding]; other site
996634004766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634004767	catalytic residue [active]
996634004768	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
996634004769	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
996634004770	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
996634004771	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
996634004772	lipoyl attachment site [posttranslational modification]; other site
996634004773	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
996634004774	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996634004775	active site
996634004776	lipoate-protein ligase B; Provisional; Region: PRK14345
996634004777	lipoyl synthase; Provisional; Region: PRK05481
996634004778	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996634004779	FeS/SAM binding site; other site
996634004780	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634004781	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634004782	Walker A/P-loop; other site
996634004783	ATP binding site [chemical binding]; other site
996634004784	Q-loop/lid; other site
996634004785	ABC transporter signature motif; other site
996634004786	Walker B; other site
996634004787	D-loop; other site
996634004788	H-loop/switch region; other site
996634004789	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634004790	ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609
996634004791	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634004792	putative PBP binding regions; other site
996634004793	ABC-ATPase subunit  interface; other site
996634004794	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634004795	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
996634004796	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634004797	ABC-ATPase subunit  interface; other site
996634004798	dimer interface [polypeptide binding]; other site
996634004799	putative PBP binding regions; other site
996634004800	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
996634004801	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634004802	intersubunit interface [polypeptide binding]; other site
996634004803	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
996634004804	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
996634004805	FAD binding pocket [chemical binding]; other site
996634004806	FAD binding motif [chemical binding]; other site
996634004807	phosphate binding motif [ion binding]; other site
996634004808	NAD binding pocket [chemical binding]; other site
996634004809	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
996634004810	RDD family; Region: RDD; pfam06271
996634004811	glutamine synthetase, type I; Region: GlnA; TIGR00653
996634004812	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
996634004813	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
996634004814	Abi-like protein; Region: Abi_2; pfam07751
996634004815	Transposase; Region: DEDD_Tnp_IS110; pfam01548
996634004816	potential frameshift: common BLAST hit: gi|227833291|ref|YP_002834998.1| putative regulatory protein
996634004817	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
996634004818	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
996634004819	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
996634004820	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
996634004821	active site
996634004822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
996634004823	Predicted permease [General function prediction only]; Region: COG2056
996634004824	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
996634004825	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
996634004826	nudix motif; other site
996634004827	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
996634004828	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
996634004829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634004830	catalytic residue [active]
996634004831	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
996634004832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634004833	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996634004834	putative substrate translocation pore; other site
996634004835	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
996634004836	heme binding pocket [chemical binding]; other site
996634004837	heme ligand [chemical binding]; other site
996634004838	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
996634004839	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996634004840	metal binding triad; other site
996634004841	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
996634004842	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996634004843	metal binding triad; other site
996634004844	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
996634004845	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
996634004846	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
996634004847	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
996634004848	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
996634004849	putative active site; other site
996634004850	putative metal binding residues [ion binding]; other site
996634004851	signature motif; other site
996634004852	putative triphosphate binding site [ion binding]; other site
996634004853	CHAD domain; Region: CHAD; pfam05235
996634004854	Sporulation related domain; Region: SPOR; cl10051
996634004855	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
996634004856	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
996634004857	RNB domain; Region: RNB; pfam00773
996634004858	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
996634004859	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
996634004860	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
996634004861	RNA/DNA hybrid binding site [nucleotide binding]; other site
996634004862	active site
996634004863	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634004864	catalytic core [active]
996634004865	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
996634004866	Putative zinc ribbon domain; Region: DUF164; pfam02591
996634004867	hypothetical protein; Provisional; Region: PRK07908
996634004868	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634004869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634004870	homodimer interface [polypeptide binding]; other site
996634004871	catalytic residue [active]
996634004872	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
996634004873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634004874	motif II; other site
996634004875	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
996634004876	Low molecular weight phosphatase family; Region: LMWPc; cd00115
996634004877	active site
996634004878	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
996634004879	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
996634004880	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
996634004881	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
996634004882	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
996634004883	dimer interface [polypeptide binding]; other site
996634004884	TPP-binding site [chemical binding]; other site
996634004885	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996634004886	Serine hydrolase; Region: Ser_hydrolase; cl17834
996634004887	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
996634004888	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
996634004889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634004890	active site
996634004891	motif I; other site
996634004892	motif II; other site
996634004893	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634004894	Beta-lactamase; Region: Beta-lactamase; pfam00144
996634004895	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
996634004896	Predicted membrane protein [Function unknown]; Region: COG2860
996634004897	UPF0126 domain; Region: UPF0126; pfam03458
996634004898	UPF0126 domain; Region: UPF0126; pfam03458
996634004899	DNA primase; Validated; Region: dnaG; PRK05667
996634004900	CHC2 zinc finger; Region: zf-CHC2; pfam01807
996634004901	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
996634004902	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
996634004903	active site
996634004904	metal binding site [ion binding]; metal-binding site
996634004905	interdomain interaction site; other site
996634004906	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
996634004907	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
996634004908	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
996634004909	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
996634004910	glutaminase active site [active]
996634004911	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
996634004912	dimer interface [polypeptide binding]; other site
996634004913	active site
996634004914	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
996634004915	dimer interface [polypeptide binding]; other site
996634004916	active site
996634004917	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
996634004918	active site
996634004919	barstar interaction site; other site
996634004920	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
996634004921	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996634004922	Zn2+ binding site [ion binding]; other site
996634004923	Mg2+ binding site [ion binding]; other site
996634004924	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
996634004925	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
996634004926	putative active site [active]
996634004927	Repair protein; Region: Repair_PSII; pfam04536
996634004928	glycyl-tRNA synthetase; Provisional; Region: PRK04173
996634004929	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996634004930	motif 1; other site
996634004931	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
996634004932	active site
996634004933	motif 2; other site
996634004934	motif 3; other site
996634004935	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
996634004936	anticodon binding site; other site
996634004937	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996634004938	putative DNA binding site [nucleotide binding]; other site
996634004939	putative Zn2+ binding site [ion binding]; other site
996634004940	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
996634004941	metal binding site 2 [ion binding]; metal-binding site
996634004942	putative DNA binding helix; other site
996634004943	metal binding site 1 [ion binding]; metal-binding site
996634004944	dimer interface [polypeptide binding]; other site
996634004945	structural Zn2+ binding site [ion binding]; other site
996634004946	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
996634004947	diiron binding motif [ion binding]; other site
996634004948	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
996634004949	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
996634004950	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
996634004951	catalytic residue [active]
996634004952	putative FPP diphosphate  binding site; other site
996634004953	putative FPP binding hydrophobic cleft; other site
996634004954	dimer interface [polypeptide binding]; other site
996634004955	putative IPP diphosphate binding site; other site
996634004956	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
996634004957	Recombination protein O N terminal; Region: RecO_N; pfam11967
996634004958	Recombination protein O C terminal; Region: RecO_C; pfam02565
996634004959	GTPase Era; Reviewed; Region: era; PRK00089
996634004960	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
996634004961	G1 box; other site
996634004962	GTP/Mg2+ binding site [chemical binding]; other site
996634004963	Switch I region; other site
996634004964	G2 box; other site
996634004965	Switch II region; other site
996634004966	G3 box; other site
996634004967	G4 box; other site
996634004968	G5 box; other site
996634004969	KH domain; Region: KH_2; pfam07650
996634004970	pyridoxamine kinase; Validated; Region: PRK05756
996634004971	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
996634004972	dimer interface [polypeptide binding]; other site
996634004973	pyridoxal binding site [chemical binding]; other site
996634004974	ATP binding site [chemical binding]; other site
996634004975	Domain of unknown function DUF21; Region: DUF21; pfam01595
996634004976	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
996634004977	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
996634004978	Transporter associated domain; Region: CorC_HlyC; smart01091
996634004979	metal-binding heat shock protein; Provisional; Region: PRK00016
996634004980	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
996634004981	PhoH-like protein; Region: PhoH; pfam02562
996634004982	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
996634004983	chaperone protein DnaJ; Provisional; Region: PRK14278
996634004984	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
996634004985	HSP70 interaction site [polypeptide binding]; other site
996634004986	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
996634004987	Zn binding sites [ion binding]; other site
996634004988	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
996634004989	dimer interface [polypeptide binding]; other site
996634004990	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
996634004991	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
996634004992	seadornavirus RNA-directed RNA polymerase; Region: seadorna_RNAP; TIGR04234
996634004993	HemN C-terminal domain; Region: HemN_C; pfam06969
996634004994	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
996634004995	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
996634004996	acyl-activating enzyme (AAE) consensus motif; other site
996634004997	putative AMP binding site [chemical binding]; other site
996634004998	putative active site [active]
996634004999	putative CoA binding site [chemical binding]; other site
996634005000	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
996634005001	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
996634005002	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
996634005003	active site
996634005004	Zn binding site [ion binding]; other site
996634005005	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
996634005006	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
996634005007	substrate binding pocket [chemical binding]; other site
996634005008	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
996634005009	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
996634005010	active site
996634005011	metal binding site [ion binding]; metal-binding site
996634005012	nudix motif; other site
996634005013	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996634005014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996634005015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634005016	Walker A/P-loop; other site
996634005017	ATP binding site [chemical binding]; other site
996634005018	Q-loop/lid; other site
996634005019	ABC transporter signature motif; other site
996634005020	Walker B; other site
996634005021	D-loop; other site
996634005022	H-loop/switch region; other site
996634005023	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
996634005024	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
996634005025	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
996634005026	Domain of unknown function (DUF222); Region: DUF222; pfam02720
996634005027	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
996634005028	active site
996634005029	BCCT family transporter; Region: BCCT; pfam02028
996634005030	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
996634005031	Predicted permeases [General function prediction only]; Region: COG0679
996634005032	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
996634005033	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
996634005034	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634005035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634005036	dimer interface [polypeptide binding]; other site
996634005037	conserved gate region; other site
996634005038	putative PBP binding loops; other site
996634005039	ABC-ATPase subunit interface; other site
996634005040	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
996634005041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634005042	dimer interface [polypeptide binding]; other site
996634005043	conserved gate region; other site
996634005044	putative PBP binding loops; other site
996634005045	ABC-ATPase subunit interface; other site
996634005046	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
996634005047	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634005048	Walker A/P-loop; other site
996634005049	ATP binding site [chemical binding]; other site
996634005050	Q-loop/lid; other site
996634005051	ABC transporter signature motif; other site
996634005052	Walker B; other site
996634005053	D-loop; other site
996634005054	H-loop/switch region; other site
996634005055	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634005056	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634005057	Walker A/P-loop; other site
996634005058	ATP binding site [chemical binding]; other site
996634005059	Q-loop/lid; other site
996634005060	ABC transporter signature motif; other site
996634005061	Walker B; other site
996634005062	D-loop; other site
996634005063	H-loop/switch region; other site
996634005064	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634005065	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
996634005066	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
996634005067	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996634005068	catalytic residue [active]
996634005069	Sulphur transport; Region: Sulf_transp; pfam04143
996634005070	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
996634005071	CPxP  motif; other site
996634005072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634005073	H-loop/switch region; other site
996634005074	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634005075	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
996634005076	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634005077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
996634005078	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
996634005079	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
996634005080	multidrug resistance protein MdtH; Provisional; Region: PRK11646
996634005081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
996634005082	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634005083	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
996634005084	Walker A/P-loop; other site
996634005085	ATP binding site [chemical binding]; other site
996634005086	Q-loop/lid; other site
996634005087	ABC transporter signature motif; other site
996634005088	Walker B; other site
996634005089	D-loop; other site
996634005090	H-loop/switch region; other site
996634005091	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634005092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634005093	Walker A/P-loop; other site
996634005094	ATP binding site [chemical binding]; other site
996634005095	Q-loop/lid; other site
996634005096	ABC transporter signature motif; other site
996634005097	Walker B; other site
996634005098	D-loop; other site
996634005099	H-loop/switch region; other site
996634005100	GTP-binding protein LepA; Provisional; Region: PRK05433
996634005101	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
996634005102	G1 box; other site
996634005103	putative GEF interaction site [polypeptide binding]; other site
996634005104	GTP/Mg2+ binding site [chemical binding]; other site
996634005105	Switch I region; other site
996634005106	G2 box; other site
996634005107	G3 box; other site
996634005108	Switch II region; other site
996634005109	G4 box; other site
996634005110	G5 box; other site
996634005111	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
996634005112	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
996634005113	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
996634005114	PemK-like protein; Region: PemK; pfam02452
996634005115	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
996634005116	LysE type translocator; Region: LysE; cl00565
996634005117	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
996634005118	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
996634005119	hypothetical protein; Validated; Region: PRK05629
996634005120	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
996634005121	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
996634005122	Competence protein; Region: Competence; pfam03772
996634005123	comEA protein; Region: comE; TIGR01259
996634005124	Helix-hairpin-helix motif; Region: HHH; pfam00633
996634005125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
996634005126	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
996634005127	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634005128	catalytic core [active]
996634005129	Oligomerisation domain; Region: Oligomerisation; pfam02410
996634005130	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
996634005131	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
996634005132	active site
996634005133	(T/H)XGH motif; other site
996634005134	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
996634005135	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
996634005136	putative catalytic cysteine [active]
996634005137	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
996634005138	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
996634005139	putative ligand binding site [chemical binding]; other site
996634005140	putative NAD binding site [chemical binding]; other site
996634005141	catalytic site [active]
996634005142	Protein of unknown function (DUF454); Region: DUF454; pfam04304
996634005143	putative transporter; Validated; Region: PRK03818
996634005144	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
996634005145	TrkA-C domain; Region: TrkA_C; pfam02080
996634005146	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
996634005147	gamma-glutamyl kinase; Provisional; Region: PRK05429
996634005148	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
996634005149	nucleotide binding site [chemical binding]; other site
996634005150	homotetrameric interface [polypeptide binding]; other site
996634005151	putative phosphate binding site [ion binding]; other site
996634005152	putative allosteric binding site; other site
996634005153	PUA domain; Region: PUA; pfam01472
996634005154	GTPase CgtA; Reviewed; Region: obgE; PRK12296
996634005155	GTP1/OBG; Region: GTP1_OBG; pfam01018
996634005156	Obg GTPase; Region: Obg; cd01898
996634005157	G1 box; other site
996634005158	GTP/Mg2+ binding site [chemical binding]; other site
996634005159	Switch I region; other site
996634005160	G2 box; other site
996634005161	G3 box; other site
996634005162	Switch II region; other site
996634005163	G4 box; other site
996634005164	G5 box; other site
996634005165	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
996634005166	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
996634005167	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
996634005168	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
996634005169	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
996634005170	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
996634005171	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
996634005172	homodimer interface [polypeptide binding]; other site
996634005173	oligonucleotide binding site [chemical binding]; other site
996634005174	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
996634005175	active site
996634005176	multimer interface [polypeptide binding]; other site
996634005177	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
996634005178	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
996634005179	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
996634005180	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
996634005181	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996634005182	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996634005183	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
996634005184	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634005185	active site
996634005186	HIGH motif; other site
996634005187	nucleotide binding site [chemical binding]; other site
996634005188	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
996634005189	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
996634005190	active site
996634005191	KMSKS motif; other site
996634005192	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
996634005193	tRNA binding surface [nucleotide binding]; other site
996634005194	anticodon binding site; other site
996634005195	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
996634005196	malate dehydrogenase; Provisional; Region: PRK05442
996634005197	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
996634005198	NAD(P) binding site [chemical binding]; other site
996634005199	dimer interface [polypeptide binding]; other site
996634005200	malate binding site [chemical binding]; other site
996634005201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634005202	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634005203	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
996634005204	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
996634005205	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
996634005206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634005207	Walker A motif; other site
996634005208	ATP binding site [chemical binding]; other site
996634005209	Walker B motif; other site
996634005210	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
996634005211	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
996634005212	Glutamine amidotransferase class-I; Region: GATase; pfam00117
996634005213	glutamine binding [chemical binding]; other site
996634005214	catalytic triad [active]
996634005215	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
996634005216	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
996634005217	substrate-cofactor binding pocket; other site
996634005218	Aminotransferase class IV; Region: Aminotran_4; pfam01063
996634005219	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634005220	catalytic residue [active]
996634005221	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
996634005222	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
996634005223	oligomer interface [polypeptide binding]; other site
996634005224	active site residues [active]
996634005225	Clp protease; Region: CLP_protease; pfam00574
996634005226	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
996634005227	oligomer interface [polypeptide binding]; other site
996634005228	active site residues [active]
996634005229	trigger factor; Provisional; Region: tig; PRK01490
996634005230	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996634005231	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
996634005232	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
996634005233	Pirin-related protein [General function prediction only]; Region: COG1741
996634005234	Pirin; Region: Pirin; pfam02678
996634005235	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
996634005236	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
996634005237	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
996634005238	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
996634005239	catalytic residues [active]
996634005240	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
996634005241	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
996634005242	Zn binding site [ion binding]; other site
996634005243	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996634005244	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996634005245	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
996634005246	apolar tunnel; other site
996634005247	heme binding site [chemical binding]; other site
996634005248	dimerization interface [polypeptide binding]; other site
996634005249	Protein of unknown function, DUF606; Region: DUF606; pfam04657
996634005250	Protein of unknown function, DUF606; Region: DUF606; pfam04657
996634005251	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
996634005252	active site
996634005253	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
996634005254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634005255	Walker A/P-loop; other site
996634005256	ATP binding site [chemical binding]; other site
996634005257	Q-loop/lid; other site
996634005258	ABC transporter signature motif; other site
996634005259	Walker B; other site
996634005260	D-loop; other site
996634005261	H-loop/switch region; other site
996634005262	ABC transporter; Region: ABC_tran_2; pfam12848
996634005263	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996634005264	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
996634005265	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
996634005266	dimer interface [polypeptide binding]; other site
996634005267	ssDNA binding site [nucleotide binding]; other site
996634005268	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996634005269	YcaO-like family; Region: YcaO; pfam02624
996634005270	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
996634005271	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
996634005272	NADPH bind site [chemical binding]; other site
996634005273	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
996634005274	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
996634005275	SpaB C-terminal domain; Region: SpaB_C; pfam14028
996634005276	YcaO-like family; Region: YcaO; pfam02624
996634005277	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
996634005278	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634005279	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996634005280	Walker A/P-loop; other site
996634005281	ATP binding site [chemical binding]; other site
996634005282	Q-loop/lid; other site
996634005283	ABC transporter signature motif; other site
996634005284	Walker B; other site
996634005285	D-loop; other site
996634005286	H-loop/switch region; other site
996634005287	Copper resistance protein D; Region: CopD; cl00563
996634005288	Predicted membrane protein [Function unknown]; Region: COG3336
996634005289	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
996634005290	Carbon starvation protein CstA; Region: CstA; pfam02554
996634005291	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
996634005292	Protein of unknown function (DUF466); Region: DUF466; pfam04328
996634005293	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
996634005294	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
996634005295	active site
996634005296	catalytic triad [active]
996634005297	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
996634005298	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
996634005299	NADP binding site [chemical binding]; other site
996634005300	dimer interface [polypeptide binding]; other site
996634005301	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
996634005302	classical (c) SDRs; Region: SDR_c; cd05233
996634005303	NAD(P) binding site [chemical binding]; other site
996634005304	active site
996634005305	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
996634005306	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
996634005307	catalytic site [active]
996634005308	putative active site [active]
996634005309	putative substrate binding site [chemical binding]; other site
996634005310	dimer interface [polypeptide binding]; other site
996634005311	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
996634005312	N-acetylneuraminate lyase; Provisional; Region: PRK04147
996634005313	inhibitor site; inhibition site
996634005314	active site
996634005315	dimer interface [polypeptide binding]; other site
996634005316	catalytic residue [active]
996634005317	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
996634005318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
996634005319	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
996634005320	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
996634005321	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
996634005322	Prostaglandin dehydrogenases; Region: PGDH; cd05288
996634005323	NAD(P) binding site [chemical binding]; other site
996634005324	substrate binding site [chemical binding]; other site
996634005325	dimer interface [polypeptide binding]; other site
996634005326	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
996634005327	Isochorismatase family; Region: Isochorismatase; pfam00857
996634005328	catalytic triad [active]
996634005329	metal binding site [ion binding]; metal-binding site
996634005330	conserved cis-peptide bond; other site
996634005331	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
996634005332	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
996634005333	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
996634005334	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
996634005335	catalytic triad [active]
996634005336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634005337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634005338	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
996634005339	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
996634005340	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
996634005341	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
996634005342	phosphate binding site [ion binding]; other site
996634005343	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
996634005344	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
996634005345	active site 2 [active]
996634005346	active site 1 [active]
996634005347	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
996634005348	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
996634005349	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
996634005350	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
996634005351	putative NAD(P) binding site [chemical binding]; other site
996634005352	active site
996634005353	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
996634005354	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
996634005355	active site
996634005356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996634005357	Histidine kinase; Region: HisKA_3; pfam07730
996634005358	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
996634005359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634005360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634005361	active site
996634005362	phosphorylation site [posttranslational modification]
996634005363	intermolecular recognition site; other site
996634005364	dimerization interface [polypeptide binding]; other site
996634005365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634005366	DNA binding residues [nucleotide binding]
996634005367	dimerization interface [polypeptide binding]; other site
996634005368	Protein of unknown function (DUF418); Region: DUF418; cl12135
996634005369	Protein of unknown function (DUF418); Region: DUF418; pfam04235
996634005370	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
996634005371	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
996634005372	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
996634005373	NodB motif; other site
996634005374	active site
996634005375	catalytic site [active]
996634005376	metal binding site [ion binding]; metal-binding site
996634005377	Glucitol operon activator protein (GutM); Region: GutM; cl01890
996634005378	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
996634005379	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
996634005380	active site
996634005381	dimerization interface [polypeptide binding]; other site
996634005382	ribonuclease PH; Reviewed; Region: rph; PRK00173
996634005383	Ribonuclease PH; Region: RNase_PH_bact; cd11362
996634005384	hexamer interface [polypeptide binding]; other site
996634005385	active site
996634005386	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
996634005387	glutamate racemase; Provisional; Region: PRK00865
996634005388	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
996634005389	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
996634005390	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
996634005391	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
996634005392	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
996634005393	active site
996634005394	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
996634005395	DEAD/DEAH box helicase; Region: DEAD; pfam00270
996634005396	ATP binding site [chemical binding]; other site
996634005397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996634005398	putative Mg++ binding site [ion binding]; other site
996634005399	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
996634005400	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
996634005401	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
996634005402	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
996634005403	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
996634005404	phosphoserine phosphatase SerB; Region: serB; TIGR00338
996634005405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634005406	motif II; other site
996634005407	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
996634005408	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
996634005409	D-pathway; other site
996634005410	Putative ubiquinol binding site [chemical binding]; other site
996634005411	Low-spin heme (heme b) binding site [chemical binding]; other site
996634005412	Putative water exit pathway; other site
996634005413	Binuclear center (heme o3/CuB) [ion binding]; other site
996634005414	K-pathway; other site
996634005415	Putative proton exit pathway; other site
996634005416	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
996634005417	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
996634005418	dimer interface [polypeptide binding]; other site
996634005419	putative radical transfer pathway; other site
996634005420	diiron center [ion binding]; other site
996634005421	tyrosyl radical; other site
996634005422	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
996634005423	Ferritin-like domain; Region: Ferritin; pfam00210
996634005424	ferroxidase diiron center [ion binding]; other site
996634005425	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
996634005426	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
996634005427	Class I ribonucleotide reductase; Region: RNR_I; cd01679
996634005428	active site
996634005429	dimer interface [polypeptide binding]; other site
996634005430	catalytic residues [active]
996634005431	effector binding site; other site
996634005432	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
996634005433	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
996634005434	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
996634005435	catalytic residues [active]
996634005436	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
996634005437	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
996634005438	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
996634005439	homodimer interface [polypeptide binding]; other site
996634005440	NAD binding pocket [chemical binding]; other site
996634005441	ATP binding pocket [chemical binding]; other site
996634005442	Mg binding site [ion binding]; other site
996634005443	active-site loop [active]
996634005444	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
996634005445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996634005446	dimerization interface [polypeptide binding]; other site
996634005447	putative DNA binding site [nucleotide binding]; other site
996634005448	putative Zn2+ binding site [ion binding]; other site
996634005449	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
996634005450	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996634005451	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
996634005452	Thioredoxin; Region: Thioredoxin_4; cl17273
996634005453	Predicted membrane protein [Function unknown]; Region: COG2259
996634005454	phosphoglucomutase; Validated; Region: PRK07564
996634005455	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
996634005456	active site
996634005457	substrate binding site [chemical binding]; other site
996634005458	metal binding site [ion binding]; metal-binding site
996634005459	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
996634005460	CrcB-like protein; Region: CRCB; pfam02537
996634005461	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996634005462	FtsX-like permease family; Region: FtsX; pfam02687
996634005463	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996634005464	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996634005465	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634005466	Walker A/P-loop; other site
996634005467	ATP binding site [chemical binding]; other site
996634005468	Q-loop/lid; other site
996634005469	ABC transporter signature motif; other site
996634005470	Walker B; other site
996634005471	D-loop; other site
996634005472	H-loop/switch region; other site
996634005473	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
996634005474	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
996634005475	hinge; other site
996634005476	active site
996634005477	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
996634005478	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634005479	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634005480	DNA binding residues [nucleotide binding]
996634005481	dimerization interface [polypeptide binding]; other site
996634005482	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
996634005483	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
996634005484	dimer interface [polypeptide binding]; other site
996634005485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634005486	catalytic residue [active]
996634005487	serine O-acetyltransferase; Region: cysE; TIGR01172
996634005488	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
996634005489	trimer interface [polypeptide binding]; other site
996634005490	active site
996634005491	substrate binding site [chemical binding]; other site
996634005492	CoA binding site [chemical binding]; other site
996634005493	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634005494	Coenzyme A binding pocket [chemical binding]; other site
996634005495	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
996634005496	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
996634005497	putative active site [active]
996634005498	metal binding site [ion binding]; metal-binding site
996634005499	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
996634005500	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
996634005501	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
996634005502	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
996634005503	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
996634005504	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
996634005505	Walker A/P-loop; other site
996634005506	ATP binding site [chemical binding]; other site
996634005507	Q-loop/lid; other site
996634005508	ABC transporter signature motif; other site
996634005509	Walker B; other site
996634005510	D-loop; other site
996634005511	H-loop/switch region; other site
996634005512	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
996634005513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634005514	Walker A/P-loop; other site
996634005515	ATP binding site [chemical binding]; other site
996634005516	Q-loop/lid; other site
996634005517	ABC transporter signature motif; other site
996634005518	Walker B; other site
996634005519	D-loop; other site
996634005520	H-loop/switch region; other site
996634005521	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
996634005522	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
996634005523	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
996634005524	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
996634005525	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
996634005526	FMN binding site [chemical binding]; other site
996634005527	active site
996634005528	catalytic residues [active]
996634005529	substrate binding site [chemical binding]; other site
996634005530	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
996634005531	PhoU domain; Region: PhoU; pfam01895
996634005532	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
996634005533	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
996634005534	Walker A/P-loop; other site
996634005535	ATP binding site [chemical binding]; other site
996634005536	Q-loop/lid; other site
996634005537	ABC transporter signature motif; other site
996634005538	Walker B; other site
996634005539	D-loop; other site
996634005540	H-loop/switch region; other site
996634005541	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
996634005542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634005543	dimer interface [polypeptide binding]; other site
996634005544	conserved gate region; other site
996634005545	putative PBP binding loops; other site
996634005546	ABC-ATPase subunit interface; other site
996634005547	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
996634005548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634005549	dimer interface [polypeptide binding]; other site
996634005550	conserved gate region; other site
996634005551	putative PBP binding loops; other site
996634005552	ABC-ATPase subunit interface; other site
996634005553	PBP superfamily domain; Region: PBP_like_2; cl17296
996634005554	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
996634005555	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
996634005556	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
996634005557	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
996634005558	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
996634005559	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
996634005560	heme-binding site [chemical binding]; other site
996634005561	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
996634005562	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
996634005563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634005564	catalytic residue [active]
996634005565	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
996634005566	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
996634005567	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
996634005568	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
996634005569	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
996634005570	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
996634005571	dimerization interface [polypeptide binding]; other site
996634005572	putative ATP binding site [chemical binding]; other site
996634005573	amidophosphoribosyltransferase; Provisional; Region: PRK07847
996634005574	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
996634005575	active site
996634005576	tetramer interface [polypeptide binding]; other site
996634005577	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634005578	active site
996634005579	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
996634005580	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
996634005581	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
996634005582	dimer interface [polypeptide binding]; other site
996634005583	putative radical transfer pathway; other site
996634005584	diiron center [ion binding]; other site
996634005585	tyrosyl radical; other site
996634005586	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
996634005587	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
996634005588	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
996634005589	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
996634005590	dimerization interface [polypeptide binding]; other site
996634005591	ATP binding site [chemical binding]; other site
996634005592	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
996634005593	dimerization interface [polypeptide binding]; other site
996634005594	ATP binding site [chemical binding]; other site
996634005595	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
996634005596	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
996634005597	putative active site [active]
996634005598	catalytic triad [active]
996634005599	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
996634005600	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
996634005601	catalytic residues [active]
996634005602	dimer interface [polypeptide binding]; other site
996634005603	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
996634005604	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996634005605	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
996634005606	ATP binding site [chemical binding]; other site
996634005607	active site
996634005608	substrate binding site [chemical binding]; other site
996634005609	adenylosuccinate lyase; Region: purB; TIGR00928
996634005610	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
996634005611	tetramer interface [polypeptide binding]; other site
996634005612	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
996634005613	TrkA-N domain; Region: TrkA_N; pfam02254
996634005614	TrkA-C domain; Region: TrkA_C; pfam02080
996634005615	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
996634005616	Cation transport protein; Region: TrkH; cl17365
996634005617	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
996634005618	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
996634005619	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
996634005620	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
996634005621	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
996634005622	nucleotide binding site/active site [active]
996634005623	HIT family signature motif; other site
996634005624	catalytic residue [active]
996634005625	PGAP1-like protein; Region: PGAP1; pfam07819
996634005626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996634005627	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996634005628	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996634005629	dimerization interface [polypeptide binding]; other site
996634005630	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996634005631	dimer interface [polypeptide binding]; other site
996634005632	phosphorylation site [posttranslational modification]
996634005633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634005634	ATP binding site [chemical binding]; other site
996634005635	Mg2+ binding site [ion binding]; other site
996634005636	G-X-G motif; other site
996634005637	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996634005638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634005639	active site
996634005640	phosphorylation site [posttranslational modification]
996634005641	intermolecular recognition site; other site
996634005642	dimerization interface [polypeptide binding]; other site
996634005643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996634005644	DNA binding site [nucleotide binding]
996634005645	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
996634005646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634005647	putative substrate translocation pore; other site
996634005648	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634005649	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634005650	Putative esterase; Region: Esterase; pfam00756
996634005651	S-formylglutathione hydrolase; Region: PLN02442
996634005652	xanthine permease; Region: pbuX; TIGR03173
996634005653	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
996634005654	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
996634005655	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
996634005656	putative active site [active]
996634005657	pyruvate dehydrogenase; Provisional; Region: PRK06546
996634005658	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
996634005659	PYR/PP interface [polypeptide binding]; other site
996634005660	tetramer interface [polypeptide binding]; other site
996634005661	dimer interface [polypeptide binding]; other site
996634005662	TPP binding site [chemical binding]; other site
996634005663	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
996634005664	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
996634005665	TPP-binding site [chemical binding]; other site
996634005666	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
996634005667	Uncharacterized conserved protein [Function unknown]; Region: COG3610
996634005668	Uncharacterized conserved protein [Function unknown]; Region: COG2966
996634005669	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
996634005670	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
996634005671	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
996634005672	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
996634005673	active site
996634005674	homotetramer interface [polypeptide binding]; other site
996634005675	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
996634005676	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
996634005677	Transcriptional regulators [Transcription]; Region: PurR; COG1609
996634005678	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
996634005679	DNA binding site [nucleotide binding]
996634005680	domain linker motif; other site
996634005681	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
996634005682	putative dimerization interface [polypeptide binding]; other site
996634005683	putative ligand binding site [chemical binding]; other site
996634005684	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
996634005685	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
996634005686	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
996634005687	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
996634005688	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
996634005689	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634005690	active site
996634005691	HIGH motif; other site
996634005692	nucleotide binding site [chemical binding]; other site
996634005693	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
996634005694	KMSKS motif; other site
996634005695	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
996634005696	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
996634005697	homotrimer interaction site [polypeptide binding]; other site
996634005698	zinc binding site [ion binding]; other site
996634005699	CDP-binding sites; other site
996634005700	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
996634005701	substrate binding site; other site
996634005702	dimer interface; other site
996634005703	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
996634005704	flagellar hook protein FlgE, epsilon proteobacterial; Region: flgE_epsilon; TIGR02489
996634005705	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996634005706	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
996634005707	Walker A motif; other site
996634005708	ATP binding site [chemical binding]; other site
996634005709	Walker B motif; other site
996634005710	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
996634005711	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
996634005712	active site clefts [active]
996634005713	zinc binding site [ion binding]; other site
996634005714	dimer interface [polypeptide binding]; other site
996634005715	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
996634005716	endonuclease III; Region: ENDO3c; smart00478
996634005717	minor groove reading motif; other site
996634005718	helix-hairpin-helix signature motif; other site
996634005719	substrate binding pocket [chemical binding]; other site
996634005720	active site
996634005721	Uncharacterized conserved protein [Function unknown]; Region: COG2966
996634005722	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
996634005723	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
996634005724	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
996634005725	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
996634005726	Clp amino terminal domain; Region: Clp_N; pfam02861
996634005727	Clp amino terminal domain; Region: Clp_N; pfam02861
996634005728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634005729	Walker A motif; other site
996634005730	ATP binding site [chemical binding]; other site
996634005731	Walker B motif; other site
996634005732	arginine finger; other site
996634005733	UvrB/uvrC motif; Region: UVR; pfam02151
996634005734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634005735	Walker A motif; other site
996634005736	ATP binding site [chemical binding]; other site
996634005737	Walker B motif; other site
996634005738	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996634005739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634005740	putative substrate translocation pore; other site
996634005741	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
996634005742	active site
996634005743	tetramer interface [polypeptide binding]; other site
996634005744	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
996634005745	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
996634005746	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
996634005747	Fic/DOC family; Region: Fic; cl00960
996634005748	Mnd1 family; Region: Mnd1; pfam03962
996634005749	Trypsin; Region: Trypsin; pfam00089
996634005750	active site
996634005751	substrate binding sites [chemical binding]; other site
996634005752	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
996634005753	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
996634005754	dimer interface [polypeptide binding]; other site
996634005755	putative anticodon binding site; other site
996634005756	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996634005757	motif 1; other site
996634005758	dimer interface [polypeptide binding]; other site
996634005759	active site
996634005760	motif 2; other site
996634005761	motif 3; other site
996634005762	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
996634005763	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
996634005764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
996634005765	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
996634005766	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
996634005767	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
996634005768	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996634005769	NAD(P) binding site [chemical binding]; other site
996634005770	catalytic residues [active]
996634005771	BCCT family transporter; Region: BCCT; cl00569
996634005772	choline dehydrogenase; Validated; Region: PRK02106
996634005773	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
996634005774	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634005775	pantoate--beta-alanine ligase; Region: panC; TIGR00018
996634005776	active site
996634005777	nucleotide binding site [chemical binding]; other site
996634005778	HIGH motif; other site
996634005779	KMSKS motif; other site
996634005780	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
996634005781	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
996634005782	catalytic center binding site [active]
996634005783	ATP binding site [chemical binding]; other site
996634005784	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
996634005785	homooctamer interface [polypeptide binding]; other site
996634005786	active site
996634005787	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
996634005788	dihydropteroate synthase; Region: DHPS; TIGR01496
996634005789	substrate binding pocket [chemical binding]; other site
996634005790	dimer interface [polypeptide binding]; other site
996634005791	inhibitor binding site; inhibition site
996634005792	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
996634005793	homodecamer interface [polypeptide binding]; other site
996634005794	GTP cyclohydrolase I; Provisional; Region: PLN03044
996634005795	active site
996634005796	putative catalytic site residues [active]
996634005797	zinc binding site [ion binding]; other site
996634005798	GTP-CH-I/GFRP interaction surface; other site
996634005799	FtsH Extracellular; Region: FtsH_ext; pfam06480
996634005800	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
996634005801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634005802	Walker A motif; other site
996634005803	ATP binding site [chemical binding]; other site
996634005804	Walker B motif; other site
996634005805	arginine finger; other site
996634005806	Peptidase family M41; Region: Peptidase_M41; pfam01434
996634005807	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634005808	active site
996634005809	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
996634005810	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
996634005811	Ligand Binding Site [chemical binding]; other site
996634005812	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
996634005813	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
996634005814	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
996634005815	dimer interface [polypeptide binding]; other site
996634005816	substrate binding site [chemical binding]; other site
996634005817	metal binding sites [ion binding]; metal-binding site
996634005818	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
996634005819	active site residue [active]
996634005820	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
996634005821	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
996634005822	Secretory lipase; Region: LIP; pfam03583
996634005823	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
996634005824	MarR family; Region: MarR_2; pfam12802
996634005825	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996634005826	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
996634005827	acyl-activating enzyme (AAE) consensus motif; other site
996634005828	AMP binding site [chemical binding]; other site
996634005829	active site
996634005830	CoA binding site [chemical binding]; other site
996634005831	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
996634005832	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
996634005833	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
996634005834	putative trimer interface [polypeptide binding]; other site
996634005835	putative CoA binding site [chemical binding]; other site
996634005836	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
996634005837	putative trimer interface [polypeptide binding]; other site
996634005838	putative CoA binding site [chemical binding]; other site
996634005839	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
996634005840	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
996634005841	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
996634005842	ring oligomerisation interface [polypeptide binding]; other site
996634005843	ATP/Mg binding site [chemical binding]; other site
996634005844	stacking interactions; other site
996634005845	hinge regions; other site
996634005846	hypothetical protein; Provisional; Region: PRK07907
996634005847	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
996634005848	active site
996634005849	metal binding site [ion binding]; metal-binding site
996634005850	dimer interface [polypeptide binding]; other site
996634005851	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
996634005852	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996634005853	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
996634005854	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996634005855	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996634005856	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
996634005857	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
996634005858	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996634005859	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
996634005860	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
996634005861	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
996634005862	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
996634005863	carboxylate-amine ligase; Provisional; Region: PRK13517
996634005864	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
996634005865	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
996634005866	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
996634005867	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
996634005868	active site
996634005869	catalytic residues [active]
996634005870	metal binding site [ion binding]; metal-binding site
996634005871	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634005872	Coenzyme A binding pocket [chemical binding]; other site
996634005873	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
996634005874	putative catalytic site [active]
996634005875	putative phosphate binding site [ion binding]; other site
996634005876	active site
996634005877	metal binding site A [ion binding]; metal-binding site
996634005878	DNA binding site [nucleotide binding]
996634005879	putative AP binding site [nucleotide binding]; other site
996634005880	putative metal binding site B [ion binding]; other site
996634005881	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
996634005882	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
996634005883	putative active site [active]
996634005884	catalytic site [active]
996634005885	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
996634005886	putative active site [active]
996634005887	catalytic site [active]
996634005888	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
996634005889	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634005890	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
996634005891	Walker A/P-loop; other site
996634005892	ATP binding site [chemical binding]; other site
996634005893	Q-loop/lid; other site
996634005894	ABC transporter signature motif; other site
996634005895	Walker B; other site
996634005896	D-loop; other site
996634005897	H-loop/switch region; other site
996634005898	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
996634005899	nudix motif; other site
996634005900	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
996634005901	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996634005902	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996634005903	substrate binding pocket [chemical binding]; other site
996634005904	membrane-bound complex binding site; other site
996634005905	hinge residues; other site
996634005906	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996634005907	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996634005908	active site
996634005909	ATP binding site [chemical binding]; other site
996634005910	substrate binding site [chemical binding]; other site
996634005911	activation loop (A-loop); other site
996634005912	propionate/acetate kinase; Provisional; Region: PRK12379
996634005913	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
996634005914	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
996634005915	ferredoxin-NADP+ reductase; Region: PLN02852
996634005916	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996634005917	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996634005918	Coenzyme A binding pocket [chemical binding]; other site
996634005919	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
996634005920	active site
996634005921	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
996634005922	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996634005923	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
996634005924	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634005925	active site
996634005926	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
996634005927	Protease prsW family; Region: PrsW-protease; pfam13367
996634005928	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
996634005929	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996634005930	catalytic residues [active]
996634005931	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
996634005932	ResB-like family; Region: ResB; pfam05140
996634005933	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
996634005934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996634005935	TPR motif; other site
996634005936	TPR repeat; Region: TPR_11; pfam13414
996634005937	binding surface
996634005938	Cytochrome c552; Region: Cytochrom_C552; pfam02335
996634005939	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
996634005940	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
996634005941	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
996634005942	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
996634005943	GDP-binding site [chemical binding]; other site
996634005944	ACT binding site; other site
996634005945	IMP binding site; other site
996634005946	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
996634005947	Predicted membrane protein [Function unknown]; Region: COG4129
996634005948	Predicted membrane protein [Function unknown]; Region: COG4129
996634005949	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
996634005950	Predicted transcriptional regulators [Transcription]; Region: COG1695
996634005951	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
996634005952	Cna protein B-type domain; Region: Cna_B; pfam05738
996634005953	Cna protein B-type domain; Region: Cna_B; pfam05738
996634005954	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
996634005955	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
996634005956	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
996634005957	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
996634005958	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
996634005959	active site
996634005960	intersubunit interface [polypeptide binding]; other site
996634005961	zinc binding site [ion binding]; other site
996634005962	Na+ binding site [ion binding]; other site
996634005963	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
996634005964	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
996634005965	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
996634005966	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996634005967	active site
996634005968	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
996634005969	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
996634005970	active site residue [active]
996634005971	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
996634005972	active site residue [active]
996634005973	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
996634005974	Uncharacterized conserved protein [Function unknown]; Region: COG1434
996634005975	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
996634005976	putative active site [active]
996634005977	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
996634005978	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
996634005979	active site
996634005980	catalytic site [active]
996634005981	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
996634005982	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
996634005983	active site
996634005984	catalytic site [active]
996634005985	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
996634005986	Clp amino terminal domain; Region: Clp_N; pfam02861
996634005987	Clp amino terminal domain; Region: Clp_N; pfam02861
996634005988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634005989	Walker A motif; other site
996634005990	ATP binding site [chemical binding]; other site
996634005991	Walker B motif; other site
996634005992	arginine finger; other site
996634005993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996634005994	Walker A motif; other site
996634005995	ATP binding site [chemical binding]; other site
996634005996	Walker B motif; other site
996634005997	arginine finger; other site
996634005998	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996634005999	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
996634006000	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996634006001	Walker A/P-loop; other site
996634006002	ATP binding site [chemical binding]; other site
996634006003	Q-loop/lid; other site
996634006004	ABC transporter signature motif; other site
996634006005	Walker B; other site
996634006006	D-loop; other site
996634006007	H-loop/switch region; other site
996634006008	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
996634006009	Septum formation initiator; Region: DivIC; cl17659
996634006010	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
996634006011	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
996634006012	FAD binding pocket [chemical binding]; other site
996634006013	conserved FAD binding motif [chemical binding]; other site
996634006014	phosphate binding motif [ion binding]; other site
996634006015	beta-alpha-beta structure motif; other site
996634006016	NAD binding pocket [chemical binding]; other site
996634006017	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996634006018	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
996634006019	FtsX-like permease family; Region: FtsX; pfam02687
996634006020	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634006021	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996634006022	Walker A/P-loop; other site
996634006023	ATP binding site [chemical binding]; other site
996634006024	Q-loop/lid; other site
996634006025	ABC transporter signature motif; other site
996634006026	Walker B; other site
996634006027	D-loop; other site
996634006028	H-loop/switch region; other site
996634006029	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
996634006030	HlyD family secretion protein; Region: HlyD_3; pfam13437
996634006031	Predicted amidohydrolase [General function prediction only]; Region: COG0388
996634006032	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
996634006033	putative active site [active]
996634006034	catalytic triad [active]
996634006035	putative dimer interface [polypeptide binding]; other site
996634006036	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
996634006037	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
996634006038	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
996634006039	NAD binding site [chemical binding]; other site
996634006040	substrate binding site [chemical binding]; other site
996634006041	catalytic Zn binding site [ion binding]; other site
996634006042	tetramer interface [polypeptide binding]; other site
996634006043	structural Zn binding site [ion binding]; other site
996634006044	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
996634006045	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996634006046	NAD(P) binding site [chemical binding]; other site
996634006047	catalytic residues [active]
996634006048	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
996634006049	active site
996634006050	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
996634006051	DNA binding residues [nucleotide binding]
996634006052	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996634006053	putative dimer interface [polypeptide binding]; other site
996634006054	chaperone protein DnaJ; Provisional; Region: PRK14279
996634006055	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
996634006056	HSP70 interaction site [polypeptide binding]; other site
996634006057	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
996634006058	Zn binding sites [ion binding]; other site
996634006059	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
996634006060	dimer interface [polypeptide binding]; other site
996634006061	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
996634006062	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
996634006063	dimer interface [polypeptide binding]; other site
996634006064	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
996634006065	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
996634006066	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
996634006067	nucleotide binding site [chemical binding]; other site
996634006068	NEF interaction site [polypeptide binding]; other site
996634006069	SBD interface [polypeptide binding]; other site
996634006070	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
996634006071	metal ion-dependent adhesion site (MIDAS); other site
996634006072	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
996634006073	active site
996634006074	catalytic site [active]
996634006075	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
996634006076	Domain of unknown function DUF20; Region: UPF0118; pfam01594
996634006077	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634006078	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
996634006079	Walker A/P-loop; other site
996634006080	ATP binding site [chemical binding]; other site
996634006081	Q-loop/lid; other site
996634006082	ABC transporter signature motif; other site
996634006083	Walker B; other site
996634006084	D-loop; other site
996634006085	H-loop/switch region; other site
996634006086	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634006087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634006088	dimer interface [polypeptide binding]; other site
996634006089	conserved gate region; other site
996634006090	putative PBP binding loops; other site
996634006091	ABC-ATPase subunit interface; other site
996634006092	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
996634006093	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634006094	Walker A/P-loop; other site
996634006095	ATP binding site [chemical binding]; other site
996634006096	Q-loop/lid; other site
996634006097	ABC transporter signature motif; other site
996634006098	Walker B; other site
996634006099	D-loop; other site
996634006100	H-loop/switch region; other site
996634006101	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634006102	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634006103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634006104	dimer interface [polypeptide binding]; other site
996634006105	conserved gate region; other site
996634006106	putative PBP binding loops; other site
996634006107	ABC-ATPase subunit interface; other site
996634006108	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
996634006109	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
996634006110	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
996634006111	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
996634006112	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
996634006113	4Fe-4S binding domain; Region: Fer4; cl02805
996634006114	Cysteine-rich domain; Region: CCG; pfam02754
996634006115	Cysteine-rich domain; Region: CCG; pfam02754
996634006116	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
996634006117	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996634006118	dimerization interface [polypeptide binding]; other site
996634006119	putative DNA binding site [nucleotide binding]; other site
996634006120	putative Zn2+ binding site [ion binding]; other site
996634006121	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634006122	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634006123	Walker A/P-loop; other site
996634006124	ATP binding site [chemical binding]; other site
996634006125	Q-loop/lid; other site
996634006126	ABC transporter signature motif; other site
996634006127	Walker B; other site
996634006128	D-loop; other site
996634006129	H-loop/switch region; other site
996634006130	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634006131	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634006132	putative PBP binding regions; other site
996634006133	ABC-ATPase subunit  interface; other site
996634006134	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
996634006135	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
996634006136	intersubunit interface [polypeptide binding]; other site
996634006137	UreD urease accessory protein; Region: UreD; pfam01774
996634006138	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996634006139	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
996634006140	UreF; Region: UreF; pfam01730
996634006141	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
996634006142	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
996634006143	dimer interface [polypeptide binding]; other site
996634006144	catalytic residues [active]
996634006145	urease subunit alpha; Reviewed; Region: ureC; PRK13207
996634006146	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
996634006147	subunit interactions [polypeptide binding]; other site
996634006148	active site
996634006149	flap region; other site
996634006150	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
996634006151	gamma-beta subunit interface [polypeptide binding]; other site
996634006152	alpha-beta subunit interface [polypeptide binding]; other site
996634006153	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
996634006154	alpha-gamma subunit interface [polypeptide binding]; other site
996634006155	beta-gamma subunit interface [polypeptide binding]; other site
996634006156	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
996634006157	EamA-like transporter family; Region: EamA; pfam00892
996634006158	EamA-like transporter family; Region: EamA; pfam00892
996634006159	aminotransferase AlaT; Validated; Region: PRK09265
996634006160	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996634006161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634006162	homodimer interface [polypeptide binding]; other site
996634006163	catalytic residue [active]
996634006164	YibE/F-like protein; Region: YibE_F; pfam07907
996634006165	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
996634006166	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
996634006167	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
996634006168	dimer interface [polypeptide binding]; other site
996634006169	putative anticodon binding site; other site
996634006170	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996634006171	motif 1; other site
996634006172	dimer interface [polypeptide binding]; other site
996634006173	active site
996634006174	motif 2; other site
996634006175	motif 3; other site
996634006176	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
996634006177	Protein of unknown function (DUF998); Region: DUF998; pfam06197
996634006178	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
996634006179	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996634006180	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
996634006181	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
996634006182	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
996634006183	trimer interface [polypeptide binding]; other site
996634006184	active site
996634006185	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996634006186	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
996634006187	NAD(P) binding site [chemical binding]; other site
996634006188	catalytic residues [active]
996634006189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634006190	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996634006191	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996634006192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634006193	Walker A/P-loop; other site
996634006194	ATP binding site [chemical binding]; other site
996634006195	Q-loop/lid; other site
996634006196	ABC transporter signature motif; other site
996634006197	Walker B; other site
996634006198	D-loop; other site
996634006199	H-loop/switch region; other site
996634006200	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996634006201	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996634006202	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634006203	Walker A/P-loop; other site
996634006204	ATP binding site [chemical binding]; other site
996634006205	Q-loop/lid; other site
996634006206	ABC transporter signature motif; other site
996634006207	Walker B; other site
996634006208	D-loop; other site
996634006209	H-loop/switch region; other site
996634006210	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
996634006211	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
996634006212	Walker A/P-loop; other site
996634006213	ATP binding site [chemical binding]; other site
996634006214	Q-loop/lid; other site
996634006215	ABC transporter signature motif; other site
996634006216	Walker B; other site
996634006217	D-loop; other site
996634006218	H-loop/switch region; other site
996634006219	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
996634006220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634006221	Walker A/P-loop; other site
996634006222	ATP binding site [chemical binding]; other site
996634006223	Q-loop/lid; other site
996634006224	ABC transporter signature motif; other site
996634006225	Walker B; other site
996634006226	D-loop; other site
996634006227	H-loop/switch region; other site
996634006228	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
996634006229	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
996634006230	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
996634006231	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
996634006232	VanW like protein; Region: VanW; pfam04294
996634006233	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
996634006234	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
996634006235	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
996634006236	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
996634006237	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
996634006238	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
996634006239	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996634006240	Methyltransferase domain; Region: Methyltransf_31; pfam13847
996634006241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634006242	S-adenosylmethionine binding site [chemical binding]; other site
996634006243	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
996634006244	active site
996634006245	substrate-binding site [chemical binding]; other site
996634006246	metal-binding site [ion binding]
996634006247	GTP binding site [chemical binding]; other site
996634006248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996634006249	S-adenosylmethionine binding site [chemical binding]; other site
996634006250	LabA_like proteins; Region: LabA_like; cd06167
996634006251	putative metal binding site [ion binding]; other site
996634006252	MMPL family; Region: MMPL; pfam03176
996634006253	MMPL family; Region: MMPL; pfam03176
996634006254	Predicted integral membrane protein [Function unknown]; Region: COG0392
996634006255	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
996634006256	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
996634006257	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
996634006258	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
996634006259	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
996634006260	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
996634006261	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
996634006262	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
996634006263	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
996634006264	active site
996634006265	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
996634006266	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
996634006267	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
996634006268	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
996634006269	acyl-activating enzyme (AAE) consensus motif; other site
996634006270	active site
996634006271	Cutinase; Region: Cutinase; pfam01083
996634006272	Putative esterase; Region: Esterase; pfam00756
996634006273	S-formylglutathione hydrolase; Region: PLN02442
996634006274	LGFP repeat; Region: LGFP; pfam08310
996634006275	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
996634006276	LGFP repeat; Region: LGFP; pfam08310
996634006277	LGFP repeat; Region: LGFP; pfam08310
996634006278	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
996634006279	Putative esterase; Region: Esterase; pfam00756
996634006280	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
996634006281	UbiA prenyltransferase family; Region: UbiA; pfam01040
996634006282	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
996634006283	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
996634006284	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
996634006285	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996634006286	Repair protein; Region: Repair_PSII; pfam04536
996634006287	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
996634006288	active site
996634006289	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
996634006290	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
996634006291	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
996634006292	active site
996634006293	catalytic site [active]
996634006294	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
996634006295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634006296	putative substrate translocation pore; other site
996634006297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634006298	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
996634006299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996634006300	UDP-galactopyranose mutase; Region: GLF; pfam03275
996634006301	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
996634006302	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996634006303	Walker A/P-loop; other site
996634006304	ATP binding site [chemical binding]; other site
996634006305	Q-loop/lid; other site
996634006306	ABC transporter signature motif; other site
996634006307	Walker B; other site
996634006308	D-loop; other site
996634006309	H-loop/switch region; other site
996634006310	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
996634006311	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996634006312	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
996634006313	putative PBP binding regions; other site
996634006314	ABC-ATPase subunit  interface; other site
996634006315	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
996634006316	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
996634006317	putative binding site residues; other site
996634006318	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
996634006319	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
996634006320	amidase catalytic site [active]
996634006321	Zn binding residues [ion binding]; other site
996634006322	substrate binding site [chemical binding]; other site
996634006323	LGFP repeat; Region: LGFP; pfam08310
996634006324	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634006325	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
996634006326	active site
996634006327	motif I; other site
996634006328	motif II; other site
996634006329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996634006330	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
996634006331	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
996634006332	putative acyl-acceptor binding pocket; other site
996634006333	seryl-tRNA synthetase; Provisional; Region: PRK05431
996634006334	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
996634006335	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
996634006336	dimer interface [polypeptide binding]; other site
996634006337	active site
996634006338	motif 1; other site
996634006339	motif 2; other site
996634006340	motif 3; other site
996634006341	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
996634006342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996634006343	DNA-binding site [nucleotide binding]; DNA binding site
996634006344	UTRA domain; Region: UTRA; pfam07702
996634006345	Septum formation; Region: Septum_form; pfam13845
996634006346	Septum formation; Region: Septum_form; pfam13845
996634006347	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
996634006348	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996634006349	catalytic core [active]
996634006350	prephenate dehydratase; Provisional; Region: PRK11898
996634006351	Prephenate dehydratase; Region: PDT; pfam00800
996634006352	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
996634006353	putative L-Phe binding site [chemical binding]; other site
996634006354	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
996634006355	Amidase; Region: Amidase; cl11426
996634006356	CAAX protease self-immunity; Region: Abi; pfam02517
996634006357	Transcriptional regulator [Transcription]; Region: LytR; COG1316
996634006358	Htaa; Region: HtaA; pfam04213
996634006359	potential frameshift: common BLAST hit: gi|227833882|ref|YP_002835589.1| amino-acid carrier protein
996634006360	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
996634006361	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
996634006362	putative active site [active]
996634006363	catalytic site [active]
996634006364	putative metal binding site [ion binding]; other site
996634006365	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
996634006366	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
996634006367	Nucleoside recognition; Region: Gate; pfam07670
996634006368	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
996634006369	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
996634006370	active site
996634006371	catalytic motif [active]
996634006372	Zn binding site [ion binding]; other site
996634006373	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
996634006374	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
996634006375	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
996634006376	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
996634006377	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
996634006378	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
996634006379	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996634006380	NAD binding site [chemical binding]; other site
996634006381	dimer interface [polypeptide binding]; other site
996634006382	substrate binding site [chemical binding]; other site
996634006383	methionine sulfoxide reductase A; Provisional; Region: PRK00058
996634006384	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
996634006385	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
996634006386	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
996634006387	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996634006388	Predicted flavoprotein [General function prediction only]; Region: COG0431
996634006389	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996634006390	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996634006391	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
996634006392	putative dimerization interface [polypeptide binding]; other site
996634006393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634006394	putative substrate translocation pore; other site
996634006395	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
996634006396	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
996634006397	GIY-YIG motif/motif A; other site
996634006398	putative active site [active]
996634006399	putative metal binding site [ion binding]; other site
996634006400	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
996634006401	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
996634006402	Uncharacterized conserved protein [Function unknown]; Region: COG3410
996634006403	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
996634006404	homodimer interface [polypeptide binding]; other site
996634006405	chemical substrate binding site [chemical binding]; other site
996634006406	oligomer interface [polypeptide binding]; other site
996634006407	metal binding site [ion binding]; metal-binding site
996634006408	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
996634006409	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
996634006410	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
996634006411	Lsr2; Region: Lsr2; pfam11774
996634006412	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634006413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634006414	active site
996634006415	phosphorylation site [posttranslational modification]
996634006416	intermolecular recognition site; other site
996634006417	dimerization interface [polypeptide binding]; other site
996634006418	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634006419	DNA binding residues [nucleotide binding]
996634006420	dimerization interface [polypeptide binding]; other site
996634006421	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996634006422	Histidine kinase; Region: HisKA_3; pfam07730
996634006423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634006424	ATP binding site [chemical binding]; other site
996634006425	Mg2+ binding site [ion binding]; other site
996634006426	G-X-G motif; other site
996634006427	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
996634006428	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
996634006429	active site
996634006430	catalytic site [active]
996634006431	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
996634006432	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
996634006433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634006434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634006435	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
996634006436	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634006437	Ligand Binding Site [chemical binding]; other site
996634006438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634006439	Ligand Binding Site [chemical binding]; other site
996634006440	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
996634006441	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
996634006442	active site
996634006443	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996634006444	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996634006445	Walker A/P-loop; other site
996634006446	ATP binding site [chemical binding]; other site
996634006447	Q-loop/lid; other site
996634006448	ABC transporter signature motif; other site
996634006449	Walker B; other site
996634006450	D-loop; other site
996634006451	H-loop/switch region; other site
996634006452	Predicted transcriptional regulators [Transcription]; Region: COG1725
996634006453	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996634006454	DNA-binding site [nucleotide binding]; DNA binding site
996634006455	LabA_like proteins; Region: LabA_like; cd06167
996634006456	putative metal binding site [ion binding]; other site
996634006457	Uncharacterized conserved protein [Function unknown]; Region: COG1432
996634006458	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
996634006459	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
996634006460	catalytic residues [active]
996634006461	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996634006462	metal-binding site [ion binding]
996634006463	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
996634006464	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996634006465	metal-binding site [ion binding]
996634006466	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996634006467	Transposase, Mutator family; Region: Transposase_mut; pfam00872
996634006468	Transposase, Mutator family; Region: Transposase_mut; pfam00872
996634006469	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
996634006470	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
996634006471	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996634006472	potential frameshift: common BLAST hit: gi|340793271|ref|YP_004758734.1| transposase for insertion sequence element
996634006473	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996634006474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996634006475	benzoate transport; Region: 2A0115; TIGR00895
996634006476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634006477	putative substrate translocation pore; other site
996634006478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996634006479	replicative DNA helicase; Provisional; Region: PRK05636
996634006480	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
996634006481	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
996634006482	Walker A motif; other site
996634006483	ATP binding site [chemical binding]; other site
996634006484	Walker B motif; other site
996634006485	DNA binding loops [nucleotide binding]
996634006486	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
996634006487	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
996634006488	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
996634006489	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
996634006490	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
996634006491	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
996634006492	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
996634006493	dimer interface [polypeptide binding]; other site
996634006494	ssDNA binding site [nucleotide binding]; other site
996634006495	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996634006496	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
996634006497	Predicted integral membrane protein [Function unknown]; Region: COG5650
996634006498	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
996634006499	Transglycosylase; Region: Transgly; pfam00912
996634006500	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
996634006501	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
996634006502	MarR family; Region: MarR; pfam01047
996634006503	MarR family; Region: MarR_2; cl17246
996634006504	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634006505	Ligand Binding Site [chemical binding]; other site
996634006506	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634006507	Ligand Binding Site [chemical binding]; other site
996634006508	short chain dehydrogenase; Provisional; Region: PRK08219
996634006509	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996634006510	NAD(P) binding site [chemical binding]; other site
996634006511	active site
996634006512	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
996634006513	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
996634006514	active site residue [active]
996634006515	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
996634006516	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
996634006517	Htaa; Region: HtaA; pfam04213
996634006518	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
996634006519	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
996634006520	dimerization interface [polypeptide binding]; other site
996634006521	DPS ferroxidase diiron center [ion binding]; other site
996634006522	ion pore; other site
996634006523	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
996634006524	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
996634006525	putative DNA binding site [nucleotide binding]; other site
996634006526	catalytic residue [active]
996634006527	putative H2TH interface [polypeptide binding]; other site
996634006528	putative catalytic residues [active]
996634006529	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
996634006530	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
996634006531	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
996634006532	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
996634006533	putative substrate binding site [chemical binding]; other site
996634006534	putative ATP binding site [chemical binding]; other site
996634006535	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
996634006536	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
996634006537	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
996634006538	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
996634006539	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
996634006540	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
996634006541	HIGH motif; other site
996634006542	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
996634006543	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634006544	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996634006545	active site
996634006546	KMSKS motif; other site
996634006547	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
996634006548	tRNA binding surface [nucleotide binding]; other site
996634006549	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996634006550	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996634006551	Walker A/P-loop; other site
996634006552	ATP binding site [chemical binding]; other site
996634006553	Q-loop/lid; other site
996634006554	ABC transporter signature motif; other site
996634006555	Walker B; other site
996634006556	D-loop; other site
996634006557	H-loop/switch region; other site
996634006558	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996634006559	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
996634006560	FtsX-like permease family; Region: FtsX; pfam02687
996634006561	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634006562	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634006563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996634006564	Histidine kinase; Region: HisKA_3; pfam07730
996634006565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996634006566	ATP binding site [chemical binding]; other site
996634006567	Mg2+ binding site [ion binding]; other site
996634006568	G-X-G motif; other site
996634006569	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996634006570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996634006571	active site
996634006572	phosphorylation site [posttranslational modification]
996634006573	intermolecular recognition site; other site
996634006574	dimerization interface [polypeptide binding]; other site
996634006575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996634006576	DNA binding residues [nucleotide binding]
996634006577	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
996634006578	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634006579	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
996634006580	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634006581	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
996634006582	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
996634006583	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
996634006584	active site
996634006585	trimer interface [polypeptide binding]; other site
996634006586	allosteric site; other site
996634006587	active site lid [active]
996634006588	hexamer (dimer of trimers) interface [polypeptide binding]; other site
996634006589	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
996634006590	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
996634006591	active site
996634006592	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
996634006593	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
996634006594	putative active site cavity [active]
996634006595	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
996634006596	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
996634006597	nucleotide binding site [chemical binding]; other site
996634006598	Transcriptional regulators [Transcription]; Region: FadR; COG2186
996634006599	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996634006600	DNA-binding site [nucleotide binding]; DNA binding site
996634006601	FCD domain; Region: FCD; pfam07729
996634006602	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
996634006603	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
996634006604	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
996634006605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634006606	dimer interface [polypeptide binding]; other site
996634006607	conserved gate region; other site
996634006608	putative PBP binding loops; other site
996634006609	ABC-ATPase subunit interface; other site
996634006610	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
996634006611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996634006612	dimer interface [polypeptide binding]; other site
996634006613	conserved gate region; other site
996634006614	putative PBP binding loops; other site
996634006615	ABC-ATPase subunit interface; other site
996634006616	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
996634006617	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634006618	Walker A/P-loop; other site
996634006619	ATP binding site [chemical binding]; other site
996634006620	Q-loop/lid; other site
996634006621	ABC transporter signature motif; other site
996634006622	Walker B; other site
996634006623	D-loop; other site
996634006624	H-loop/switch region; other site
996634006625	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
996634006626	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
996634006627	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996634006628	Walker A/P-loop; other site
996634006629	ATP binding site [chemical binding]; other site
996634006630	Q-loop/lid; other site
996634006631	ABC transporter signature motif; other site
996634006632	Walker B; other site
996634006633	D-loop; other site
996634006634	H-loop/switch region; other site
996634006635	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996634006636	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
996634006637	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
996634006638	inhibitor site; inhibition site
996634006639	active site
996634006640	dimer interface [polypeptide binding]; other site
996634006641	catalytic residue [active]
996634006642	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
996634006643	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
996634006644	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996634006645	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
996634006646	tetramerization interface [polypeptide binding]; other site
996634006647	NAD(P) binding site [chemical binding]; other site
996634006648	catalytic residues [active]
996634006649	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
996634006650	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996634006651	inhibitor-cofactor binding pocket; inhibition site
996634006652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634006653	catalytic residue [active]
996634006654	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
996634006655	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
996634006656	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
996634006657	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
996634006658	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
996634006659	NAD(P) binding site [chemical binding]; other site
996634006660	catalytic residues [active]
996634006661	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
996634006662	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634006663	Ligand Binding Site [chemical binding]; other site
996634006664	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996634006665	Ligand Binding Site [chemical binding]; other site
996634006666	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
996634006667	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996634006668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996634006669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996634006670	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
996634006671	active site
996634006672	catalytic residues [active]
996634006673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
996634006674	hypothetical protein; Provisional; Region: PRK13663
996634006675	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
996634006676	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
996634006677	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
996634006678	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
996634006679	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
996634006680	active site lid residues [active]
996634006681	substrate binding pocket [chemical binding]; other site
996634006682	catalytic residues [active]
996634006683	substrate-Mg2+ binding site; other site
996634006684	aspartate-rich region 1; other site
996634006685	aspartate-rich region 2; other site
996634006686	phytoene desaturase; Region: crtI_fam; TIGR02734
996634006687	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996634006688	SdpI/YhfL protein family; Region: SdpI; pfam13630
996634006689	anthranilate synthase component I; Provisional; Region: PRK13564
996634006690	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
996634006691	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
996634006692	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
996634006693	Glutamine amidotransferase class-I; Region: GATase; pfam00117
996634006694	glutamine binding [chemical binding]; other site
996634006695	catalytic triad [active]
996634006696	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
996634006697	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
996634006698	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
996634006699	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
996634006700	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
996634006701	active site
996634006702	ribulose/triose binding site [chemical binding]; other site
996634006703	phosphate binding site [ion binding]; other site
996634006704	substrate (anthranilate) binding pocket [chemical binding]; other site
996634006705	product (indole) binding pocket [chemical binding]; other site
996634006706	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
996634006707	active site
996634006708	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
996634006709	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
996634006710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996634006711	catalytic residue [active]
996634006712	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
996634006713	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
996634006714	substrate binding site [chemical binding]; other site
996634006715	active site
996634006716	catalytic residues [active]
996634006717	heterodimer interface [polypeptide binding]; other site
996634006718	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
996634006719	iron-sulfur cluster [ion binding]; other site
996634006720	[2Fe-2S] cluster binding site [ion binding]; other site
996634006721	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
996634006722	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
996634006723	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
996634006724	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
996634006725	hypothetical protein; Validated; Region: PRK00228
996634006726	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
996634006727	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
996634006728	active site
996634006729	NTP binding site [chemical binding]; other site
996634006730	metal binding triad [ion binding]; metal-binding site
996634006731	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
996634006732	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996634006733	Zn2+ binding site [ion binding]; other site
996634006734	Mg2+ binding site [ion binding]; other site
996634006735	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
996634006736	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
996634006737	active site
996634006738	Ap6A binding site [chemical binding]; other site
996634006739	nudix motif; other site
996634006740	metal binding site [ion binding]; metal-binding site
996634006741	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
996634006742	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
996634006743	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
996634006744	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996634006745	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996634006746	DNA binding residues [nucleotide binding]
996634006747	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
996634006748	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996634006749	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996634006750	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
996634006751	catalytic residues [active]
996634006752	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
996634006753	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
996634006754	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
996634006755	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
996634006756	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
996634006757	active site
996634006758	metal binding site [ion binding]; metal-binding site
996634006759	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
996634006760	ParB-like nuclease domain; Region: ParBc; pfam02195
996634006761	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
996634006762	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996634006763	P-loop; other site
996634006764	Magnesium ion binding site [ion binding]; other site
996634006765	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996634006766	Magnesium ion binding site [ion binding]; other site
996634006767	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
996634006768	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
996634006769	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
996634006770	Haemolytic domain; Region: Haemolytic; pfam01809
996634006771	ribonuclease P; Reviewed; Region: rnpA; PRK03459
996634006772	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
996634006773	putative DnaA box, TCATCCACT
996634006774	putative DnaA box, TGTGAATAA