-- dump date 20140619_052947 -- class Genbank::misc_feature -- table misc_feature_note -- id note 945711000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 945711000003 Walker A motif; other site 945711000004 ATP binding site [chemical binding]; other site 945711000005 Walker B motif; other site 945711000006 arginine finger; other site 945711000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 945711000008 DnaA box-binding interface [nucleotide binding]; other site 945711000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 945711000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 945711000011 putative DNA binding surface [nucleotide binding]; other site 945711000012 dimer interface [polypeptide binding]; other site 945711000013 beta-clamp/clamp loader binding surface; other site 945711000014 beta-clamp/translesion DNA polymerase binding surface; other site 945711000015 recombination protein F; Reviewed; Region: recF; PRK00064 945711000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 945711000017 Walker A/P-loop; other site 945711000018 ATP binding site [chemical binding]; other site 945711000019 Q-loop/lid; other site 945711000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711000021 ABC transporter signature motif; other site 945711000022 Walker B; other site 945711000023 D-loop; other site 945711000024 H-loop/switch region; other site 945711000025 hypothetical protein; Provisional; Region: PRK00111 945711000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 945711000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711000028 ATP binding site [chemical binding]; other site 945711000029 Mg2+ binding site [ion binding]; other site 945711000030 G-X-G motif; other site 945711000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 945711000032 anchoring element; other site 945711000033 dimer interface [polypeptide binding]; other site 945711000034 ATP binding site [chemical binding]; other site 945711000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 945711000036 active site 945711000037 putative metal-binding site [ion binding]; other site 945711000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 945711000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945711000040 metal binding site [ion binding]; metal-binding site 945711000041 DNA gyrase subunit A; Validated; Region: PRK05560 945711000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 945711000043 CAP-like domain; other site 945711000044 active site 945711000045 primary dimer interface [polypeptide binding]; other site 945711000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945711000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945711000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945711000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945711000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945711000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945711000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 945711000053 YwiC-like protein; Region: YwiC; pfam14256 945711000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 945711000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 945711000056 putative ligand binding site [chemical binding]; other site 945711000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 945711000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 945711000059 TM-ABC transporter signature motif; other site 945711000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 945711000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 945711000062 Walker A/P-loop; other site 945711000063 ATP binding site [chemical binding]; other site 945711000064 Q-loop/lid; other site 945711000065 ABC transporter signature motif; other site 945711000066 Walker B; other site 945711000067 D-loop; other site 945711000068 H-loop/switch region; other site 945711000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 945711000070 active site 945711000071 Rhomboid family; Region: Rhomboid; pfam01694 945711000072 DIRP; Region: DIRP; pfam06584 945711000073 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 945711000074 Zeta toxin; Region: Zeta_toxin; pfam06414 945711000075 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 945711000076 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 945711000077 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 945711000078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 945711000079 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 945711000080 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 945711000081 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 945711000082 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 945711000083 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 945711000084 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 945711000085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 945711000086 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 945711000087 putative active site [active] 945711000088 catalytic site [active] 945711000089 Mg binding site [ion binding]; other site 945711000090 catalytic loop [active] 945711000091 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711000092 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711000093 Walker A/P-loop; other site 945711000094 ATP binding site [chemical binding]; other site 945711000095 Q-loop/lid; other site 945711000096 ABC transporter signature motif; other site 945711000097 Walker B; other site 945711000098 D-loop; other site 945711000099 H-loop/switch region; other site 945711000100 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711000101 ABC-ATPase subunit interface; other site 945711000102 dimer interface [polypeptide binding]; other site 945711000103 putative PBP binding regions; other site 945711000104 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711000105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711000106 ABC-ATPase subunit interface; other site 945711000107 dimer interface [polypeptide binding]; other site 945711000108 putative PBP binding regions; other site 945711000109 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 945711000110 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 945711000111 siderophore binding site; other site 945711000112 putative septation inhibitor protein; Reviewed; Region: PRK00159 945711000113 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 945711000114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 945711000115 active site 945711000116 ATP binding site [chemical binding]; other site 945711000117 substrate binding site [chemical binding]; other site 945711000118 activation loop (A-loop); other site 945711000119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 945711000120 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711000121 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711000122 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711000123 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711000124 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 945711000125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 945711000126 active site 945711000127 ATP binding site [chemical binding]; other site 945711000128 substrate binding site [chemical binding]; other site 945711000129 activation loop (A-loop); other site 945711000130 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 945711000131 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 945711000132 Protein phosphatase 2C; Region: PP2C; pfam00481 945711000133 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 945711000134 active site 945711000135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 945711000136 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 945711000137 phosphopeptide binding site; other site 945711000138 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 945711000139 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 945711000140 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 945711000141 phosphopeptide binding site; other site 945711000142 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 945711000143 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 945711000144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945711000145 Walker A/P-loop; other site 945711000146 ATP binding site [chemical binding]; other site 945711000147 Q-loop/lid; other site 945711000148 ABC transporter signature motif; other site 945711000149 Walker B; other site 945711000150 D-loop; other site 945711000151 H-loop/switch region; other site 945711000152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 945711000153 Histidine kinase; Region: HisKA_3; pfam07730 945711000154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711000155 Mg2+ binding site [ion binding]; other site 945711000156 G-X-G motif; other site 945711000157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711000158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711000159 active site 945711000160 phosphorylation site [posttranslational modification] 945711000161 intermolecular recognition site; other site 945711000162 dimerization interface [polypeptide binding]; other site 945711000163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711000164 DNA binding residues [nucleotide binding] 945711000165 dimerization interface [polypeptide binding]; other site 945711000166 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 945711000167 CAAX protease self-immunity; Region: Abi; pfam02517 945711000168 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 945711000169 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 945711000170 active site residue [active] 945711000171 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 945711000172 active site residue [active] 945711000173 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 945711000174 Predicted transcriptional regulators [Transcription]; Region: COG1695 945711000175 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 945711000176 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 945711000177 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711000178 intersubunit interface [polypeptide binding]; other site 945711000179 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711000180 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711000181 Walker A/P-loop; other site 945711000182 ATP binding site [chemical binding]; other site 945711000183 Q-loop/lid; other site 945711000184 ABC transporter signature motif; other site 945711000185 Walker B; other site 945711000186 D-loop; other site 945711000187 H-loop/switch region; other site 945711000188 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711000189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711000190 ABC-ATPase subunit interface; other site 945711000191 dimer interface [polypeptide binding]; other site 945711000192 putative PBP binding regions; other site 945711000193 MgtE intracellular N domain; Region: MgtE_N; cl15244 945711000194 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 945711000195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 945711000196 Divalent cation transporter; Region: MgtE; cl00786 945711000197 trehalose synthase; Region: treS_nterm; TIGR02456 945711000198 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 945711000199 active site 945711000200 catalytic site [active] 945711000201 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 945711000202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711000203 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 945711000204 Walker A/P-loop; other site 945711000205 ATP binding site [chemical binding]; other site 945711000206 Q-loop/lid; other site 945711000207 ABC transporter signature motif; other site 945711000208 Walker B; other site 945711000209 D-loop; other site 945711000210 H-loop/switch region; other site 945711000211 SdpI/YhfL protein family; Region: SdpI; pfam13630 945711000212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711000213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711000214 active site 945711000215 phosphorylation site [posttranslational modification] 945711000216 intermolecular recognition site; other site 945711000217 dimerization interface [polypeptide binding]; other site 945711000218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711000219 DNA binding residues [nucleotide binding] 945711000220 dimerization interface [polypeptide binding]; other site 945711000221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945711000222 Histidine kinase; Region: HisKA_3; pfam07730 945711000223 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 945711000224 SdpI/YhfL protein family; Region: SdpI; pfam13630 945711000225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711000226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711000227 putative substrate translocation pore; other site 945711000228 Anti-sigma-K factor rskA; Region: RskA; pfam10099 945711000229 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 945711000230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711000231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711000232 DNA binding residues [nucleotide binding] 945711000233 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 945711000234 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 945711000235 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 945711000236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945711000237 catalytic residues [active] 945711000238 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 945711000239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711000240 dimer interface [polypeptide binding]; other site 945711000241 conserved gate region; other site 945711000242 putative PBP binding loops; other site 945711000243 ABC-ATPase subunit interface; other site 945711000244 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 945711000245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711000246 Walker A/P-loop; other site 945711000247 ATP binding site [chemical binding]; other site 945711000248 Q-loop/lid; other site 945711000249 ABC transporter signature motif; other site 945711000250 Walker B; other site 945711000251 D-loop; other site 945711000252 H-loop/switch region; other site 945711000253 Integrase core domain; Region: rve_3; pfam13683 945711000254 Replicase family; Region: Replicase; pfam03090 945711000255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945711000256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711000257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711000258 active site 945711000259 phosphorylation site [posttranslational modification] 945711000260 intermolecular recognition site; other site 945711000261 dimerization interface [polypeptide binding]; other site 945711000262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711000263 DNA binding residues [nucleotide binding] 945711000264 dimerization interface [polypeptide binding]; other site 945711000265 HTH-like domain; Region: HTH_21; pfam13276 945711000266 Integrase core domain; Region: rve; pfam00665 945711000267 HicB family; Region: HicB; pfam05534 945711000268 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 945711000269 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 945711000270 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 945711000271 putative metal binding site [ion binding]; other site 945711000272 biotin synthase; Validated; Region: PRK06256 945711000273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711000274 FeS/SAM binding site; other site 945711000275 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 945711000276 MepB protein; Region: MepB; cl01985 945711000277 AMP nucleosidase; Provisional; Region: PRK08292 945711000278 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 945711000279 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 945711000280 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 945711000281 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 945711000282 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945711000283 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 945711000284 active site 945711000285 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 945711000286 active site 945711000287 catalytic site [active] 945711000288 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 945711000289 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 945711000290 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 945711000291 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 945711000292 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 945711000293 active site 945711000294 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 945711000295 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 945711000296 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 945711000297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711000298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711000299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711000300 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 945711000301 putative substrate translocation pore; other site 945711000302 PIN domain; Region: PIN_3; pfam13470 945711000303 Helix-turn-helix domain; Region: HTH_17; cl17695 945711000304 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 945711000305 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 945711000306 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 945711000307 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 945711000308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 945711000309 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 945711000310 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 945711000311 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 945711000312 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 945711000313 Lipase (class 2); Region: Lipase_2; pfam01674 945711000314 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 945711000315 dimer interface [polypeptide binding]; other site 945711000316 FMN binding site [chemical binding]; other site 945711000317 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 945711000318 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 945711000319 trimer interface [polypeptide binding]; other site 945711000320 putative metal binding site [ion binding]; other site 945711000321 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 945711000322 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 945711000323 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 945711000324 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 945711000325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945711000326 Coenzyme A binding pocket [chemical binding]; other site 945711000327 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 945711000328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 945711000329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945711000330 MarR family; Region: MarR; pfam01047 945711000331 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 945711000332 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 945711000333 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 945711000334 hypothetical protein; Provisional; Region: PRK10621 945711000335 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 945711000336 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 945711000337 active site 945711000338 phosphorylation site [posttranslational modification] 945711000339 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 945711000340 active site 945711000341 P-loop; other site 945711000342 phosphorylation site [posttranslational modification] 945711000343 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 945711000344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711000345 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 945711000346 putative Mg++ binding site [ion binding]; other site 945711000347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711000348 nucleotide binding region [chemical binding]; other site 945711000349 ATP-binding site [chemical binding]; other site 945711000350 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 945711000351 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 945711000352 maltose O-acetyltransferase; Provisional; Region: PRK10092 945711000353 active site 945711000354 substrate binding site [chemical binding]; other site 945711000355 trimer interface [polypeptide binding]; other site 945711000356 CoA binding site [chemical binding]; other site 945711000357 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 945711000358 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 945711000359 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 945711000360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711000361 NAD(P) binding site [chemical binding]; other site 945711000362 active site 945711000363 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 945711000364 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 945711000365 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711000366 RNA binding surface [nucleotide binding]; other site 945711000367 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 945711000368 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945711000369 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 945711000370 Domain of unknown function (DUF222); Region: DUF222; pfam02720 945711000371 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945711000372 active site 945711000373 glycerol kinase; Provisional; Region: glpK; PRK00047 945711000374 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 945711000375 N- and C-terminal domain interface [polypeptide binding]; other site 945711000376 active site 945711000377 MgATP binding site [chemical binding]; other site 945711000378 catalytic site [active] 945711000379 metal binding site [ion binding]; metal-binding site 945711000380 putative homotetramer interface [polypeptide binding]; other site 945711000381 glycerol binding site [chemical binding]; other site 945711000382 homodimer interface [polypeptide binding]; other site 945711000383 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 945711000384 amphipathic channel; other site 945711000385 Asn-Pro-Ala signature motifs; other site 945711000386 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 945711000387 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 945711000388 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 945711000389 active site 945711000390 Zn binding site [ion binding]; other site 945711000391 Protease prsW family; Region: PrsW-protease; pfam13367 945711000392 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 945711000393 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 945711000394 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 945711000395 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 945711000396 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 945711000397 classical (c) SDRs; Region: SDR_c; cd05233 945711000398 NAD(P) binding site [chemical binding]; other site 945711000399 active site 945711000400 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 945711000401 FAD binding domain; Region: FAD_binding_4; pfam01565 945711000402 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 945711000403 Predicted membrane protein [Function unknown]; Region: COG2246 945711000404 GtrA-like protein; Region: GtrA; pfam04138 945711000405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 945711000406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945711000407 active site 945711000408 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711000409 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 945711000410 intersubunit interface [polypeptide binding]; other site 945711000411 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 945711000412 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 945711000413 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 945711000414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711000415 ABC-ATPase subunit interface; other site 945711000416 dimer interface [polypeptide binding]; other site 945711000417 putative PBP binding regions; other site 945711000418 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 945711000419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711000420 ABC-ATPase subunit interface; other site 945711000421 dimer interface [polypeptide binding]; other site 945711000422 putative PBP binding regions; other site 945711000423 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711000424 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 945711000425 intersubunit interface [polypeptide binding]; other site 945711000426 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 945711000427 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945711000428 active site 945711000429 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 945711000430 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 945711000431 Walker A/P-loop; other site 945711000432 ATP binding site [chemical binding]; other site 945711000433 Q-loop/lid; other site 945711000434 ABC transporter signature motif; other site 945711000435 Walker B; other site 945711000436 D-loop; other site 945711000437 H-loop/switch region; other site 945711000438 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 945711000439 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 945711000440 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 945711000441 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 945711000442 Beta-lactamase; Region: Beta-lactamase; pfam00144 945711000443 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 945711000444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945711000445 dimerization interface [polypeptide binding]; other site 945711000446 putative DNA binding site [nucleotide binding]; other site 945711000447 putative Zn2+ binding site [ion binding]; other site 945711000448 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 945711000449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711000450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711000451 homodimer interface [polypeptide binding]; other site 945711000452 catalytic residue [active] 945711000453 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 945711000454 transmembrane helices; other site 945711000455 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 945711000456 CAT RNA binding domain; Region: CAT_RBD; smart01061 945711000457 PRD domain; Region: PRD; pfam00874 945711000458 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 945711000459 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 945711000460 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 945711000461 active site turn [active] 945711000462 phosphorylation site [posttranslational modification] 945711000463 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 945711000464 HPr interaction site; other site 945711000465 glycerol kinase (GK) interaction site [polypeptide binding]; other site 945711000466 active site 945711000467 phosphorylation site [posttranslational modification] 945711000468 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 945711000469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945711000470 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 945711000471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945711000472 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945711000473 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 945711000474 Protein of unknown function (DUF433); Region: DUF433; pfam04255 945711000475 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 945711000476 active site 945711000477 catalytic residues [active] 945711000478 DNA binding site [nucleotide binding] 945711000479 Int/Topo IB signature motif; other site 945711000480 Ribosome inactivating protein; Region: RIP; pfam00161 945711000481 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 945711000482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 945711000483 DNA-binding site [nucleotide binding]; DNA binding site 945711000484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711000485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711000486 homodimer interface [polypeptide binding]; other site 945711000487 catalytic residue [active] 945711000488 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 945711000489 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 945711000490 active site 945711000491 multimer interface [polypeptide binding]; other site 945711000492 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 945711000493 predicted active site [active] 945711000494 catalytic triad [active] 945711000495 prephenate dehydrogenase; Validated; Region: PRK06545 945711000496 prephenate dehydrogenase; Validated; Region: PRK08507 945711000497 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 945711000498 nucleoside/Zn binding site; other site 945711000499 dimer interface [polypeptide binding]; other site 945711000500 catalytic motif [active] 945711000501 MMPL family; Region: MMPL; pfam03176 945711000502 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 945711000503 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 945711000504 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 945711000505 active site 945711000506 HIGH motif; other site 945711000507 nucleotide binding site [chemical binding]; other site 945711000508 active site 945711000509 KMSKS motif; other site 945711000510 fructuronate transporter; Provisional; Region: PRK10034; cl15264 945711000511 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 945711000512 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 945711000513 ATP-binding site [chemical binding]; other site 945711000514 Gluconate-6-phosphate binding site [chemical binding]; other site 945711000515 Shikimate kinase; Region: SKI; pfam01202 945711000516 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 945711000517 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 945711000518 putative NAD(P) binding site [chemical binding]; other site 945711000519 catalytic Zn binding site [ion binding]; other site 945711000520 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 945711000521 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 945711000522 NADP binding site [chemical binding]; other site 945711000523 homodimer interface [polypeptide binding]; other site 945711000524 active site 945711000525 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 945711000526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711000527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711000528 homodimer interface [polypeptide binding]; other site 945711000529 catalytic residue [active] 945711000530 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 945711000531 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 945711000532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711000533 Walker A motif; other site 945711000534 ATP binding site [chemical binding]; other site 945711000535 Walker B motif; other site 945711000536 arginine finger; other site 945711000537 hypothetical protein; Validated; Region: PRK00153 945711000538 recombination protein RecR; Reviewed; Region: recR; PRK00076 945711000539 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 945711000540 RecR protein; Region: RecR; pfam02132 945711000541 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 945711000542 putative active site [active] 945711000543 putative metal-binding site [ion binding]; other site 945711000544 tetramer interface [polypeptide binding]; other site 945711000545 putative transporter; Provisional; Region: PRK09821 945711000546 GntP family permease; Region: GntP_permease; pfam02447 945711000547 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 945711000548 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 945711000549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 945711000550 Transcriptional regulators [Transcription]; Region: FadR; COG2186 945711000551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 945711000552 DNA-binding site [nucleotide binding]; DNA binding site 945711000553 FCD domain; Region: FCD; pfam07729 945711000554 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 945711000555 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 945711000556 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 945711000557 catalytic triad [active] 945711000558 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 945711000559 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945711000560 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 945711000561 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 945711000562 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 945711000563 active site 945711000564 catalytic site [active] 945711000565 substrate binding site [chemical binding]; other site 945711000566 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 945711000567 putative YPXnL-motif binding site; other site 945711000568 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 945711000569 dimer interface [polypeptide binding]; other site 945711000570 FMN binding site [chemical binding]; other site 945711000571 NADPH bind site [chemical binding]; other site 945711000572 2-isopropylmalate synthase; Validated; Region: PRK03739 945711000573 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 945711000574 active site 945711000575 catalytic residues [active] 945711000576 metal binding site [ion binding]; metal-binding site 945711000577 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 945711000578 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 945711000579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711000580 DNA binding residues [nucleotide binding] 945711000581 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 945711000582 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 945711000583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711000584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711000585 putative substrate translocation pore; other site 945711000586 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 945711000587 intersubunit interface [polypeptide binding]; other site 945711000588 active site 945711000589 catalytic residue [active] 945711000590 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 945711000591 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 945711000592 active site 945711000593 substrate binding site [chemical binding]; other site 945711000594 metal binding site [ion binding]; metal-binding site 945711000595 TQXA domain; Region: TQXA_dom; TIGR03934 945711000596 Cna protein B-type domain; Region: Cna_B; pfam05738 945711000597 Cna protein B-type domain; Region: Cna_B; pfam05738 945711000598 Cna protein B-type domain; Region: Cna_B; pfam05738 945711000599 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711000600 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945711000601 Walker A/P-loop; other site 945711000602 ATP binding site [chemical binding]; other site 945711000603 Q-loop/lid; other site 945711000604 ABC transporter signature motif; other site 945711000605 Walker B; other site 945711000606 D-loop; other site 945711000607 H-loop/switch region; other site 945711000608 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 945711000609 aspartate kinase; Reviewed; Region: PRK06635 945711000610 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 945711000611 putative nucleotide binding site [chemical binding]; other site 945711000612 putative catalytic residues [active] 945711000613 putative Mg ion binding site [ion binding]; other site 945711000614 putative aspartate binding site [chemical binding]; other site 945711000615 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 945711000616 putative allosteric regulatory site; other site 945711000617 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 945711000618 putative allosteric regulatory residue; other site 945711000619 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 945711000620 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 945711000621 RNA polymerase sigma factor; Provisional; Region: PRK12535 945711000622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711000623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711000624 DNA binding residues [nucleotide binding] 945711000625 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 945711000626 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 945711000627 heme binding pocket [chemical binding]; other site 945711000628 LGFP repeat; Region: LGFP; pfam08310 945711000629 LGFP repeat; Region: LGFP; pfam08310 945711000630 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 945711000631 tail fiber protein; Region: PHA00430 945711000632 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 945711000633 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 945711000634 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 945711000635 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 945711000636 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945711000637 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 945711000638 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 945711000639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945711000640 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 945711000641 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 945711000642 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 945711000643 Predicted membrane protein [Function unknown]; Region: COG1511 945711000644 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 945711000645 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 945711000646 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 945711000647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711000648 Walker A/P-loop; other site 945711000649 ATP binding site [chemical binding]; other site 945711000650 Q-loop/lid; other site 945711000651 ABC transporter signature motif; other site 945711000652 Walker B; other site 945711000653 D-loop; other site 945711000654 H-loop/switch region; other site 945711000655 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 945711000656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945711000657 putative active site [active] 945711000658 putative metal binding site [ion binding]; other site 945711000659 Transglycosylase; Region: Transgly; pfam00912 945711000660 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 945711000661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 945711000662 PASTA domain; Region: PASTA; pfam03793 945711000663 Transcription factor WhiB; Region: Whib; pfam02467 945711000664 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 945711000665 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 945711000666 homotrimer interaction site [polypeptide binding]; other site 945711000667 putative active site [active] 945711000668 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 945711000669 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945711000670 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945711000671 ligand binding site [chemical binding]; other site 945711000672 flexible hinge region; other site 945711000673 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 945711000674 putative switch regulator; other site 945711000675 non-specific DNA interactions [nucleotide binding]; other site 945711000676 DNA binding site [nucleotide binding] 945711000677 sequence specific DNA binding site [nucleotide binding]; other site 945711000678 putative cAMP binding site [chemical binding]; other site 945711000679 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 945711000680 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 945711000681 minor groove reading motif; other site 945711000682 helix-hairpin-helix signature motif; other site 945711000683 substrate binding pocket [chemical binding]; other site 945711000684 active site 945711000685 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 945711000686 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 945711000687 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945711000688 catalytic residues [active] 945711000689 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 945711000690 putative active site [active] 945711000691 putative CoA binding site [chemical binding]; other site 945711000692 nudix motif; other site 945711000693 metal binding site [ion binding]; metal-binding site 945711000694 Colicin V production protein; Region: Colicin_V; pfam02674 945711000695 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 945711000696 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945711000697 active site 945711000698 substrate binding sites [chemical binding]; other site 945711000699 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 945711000700 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 945711000701 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 945711000702 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 945711000703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711000704 motif II; other site 945711000705 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 945711000706 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 945711000707 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 945711000708 ATP binding site [chemical binding]; other site 945711000709 Walker A motif; other site 945711000710 hexamer interface [polypeptide binding]; other site 945711000711 Walker B motif; other site 945711000712 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 945711000713 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 945711000714 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 945711000715 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 945711000716 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 945711000717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711000718 ATP binding site [chemical binding]; other site 945711000719 putative Mg++ binding site [ion binding]; other site 945711000720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711000721 nucleotide binding region [chemical binding]; other site 945711000722 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 945711000723 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 945711000724 DNA-binding site [nucleotide binding]; DNA binding site 945711000725 RNA-binding motif; other site 945711000726 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 945711000727 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 945711000728 active site 945711000729 interdomain interaction site; other site 945711000730 putative metal-binding site [ion binding]; other site 945711000731 nucleotide binding site [chemical binding]; other site 945711000732 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 945711000733 domain I; other site 945711000734 DNA binding groove [nucleotide binding] 945711000735 phosphate binding site [ion binding]; other site 945711000736 domain II; other site 945711000737 domain III; other site 945711000738 nucleotide binding site [chemical binding]; other site 945711000739 catalytic site [active] 945711000740 domain IV; other site 945711000741 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 945711000742 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 945711000743 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 945711000744 Predicted membrane protein [Function unknown]; Region: COG1297 945711000745 putative oligopeptide transporter, OPT family; Region: TIGR00733 945711000746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945711000747 dimerization interface [polypeptide binding]; other site 945711000748 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 945711000749 cyclase homology domain; Region: CHD; cd07302 945711000750 nucleotidyl binding site; other site 945711000751 metal binding site [ion binding]; metal-binding site 945711000752 dimer interface [polypeptide binding]; other site 945711000753 DNA polymerase III subunit delta'; Validated; Region: PRK07940 945711000754 DNA polymerase III subunit delta'; Validated; Region: PRK08485 945711000755 acyl-CoA synthetase; Validated; Region: PRK07788 945711000756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945711000757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945711000758 acyl-activating enzyme (AAE) consensus motif; other site 945711000759 acyl-activating enzyme (AAE) consensus motif; other site 945711000760 AMP binding site [chemical binding]; other site 945711000761 active site 945711000762 CoA binding site [chemical binding]; other site 945711000763 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 945711000764 active site 945711000765 catalytic triad [active] 945711000766 oxyanion hole [active] 945711000767 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 945711000768 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 945711000769 substrate binding site; other site 945711000770 tetramer interface; other site 945711000771 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 945711000772 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 945711000773 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 945711000774 NADP binding site [chemical binding]; other site 945711000775 active site 945711000776 putative substrate binding site [chemical binding]; other site 945711000777 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 945711000778 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 945711000779 NAD binding site [chemical binding]; other site 945711000780 substrate binding site [chemical binding]; other site 945711000781 homodimer interface [polypeptide binding]; other site 945711000782 active site 945711000783 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 945711000784 Zn binding site [ion binding]; other site 945711000785 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 945711000786 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945711000787 Putative esterase; Region: Esterase; pfam00756 945711000788 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 945711000789 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 945711000790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945711000791 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 945711000792 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 945711000793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 945711000794 non-specific DNA binding site [nucleotide binding]; other site 945711000795 salt bridge; other site 945711000796 sequence-specific DNA binding site [nucleotide binding]; other site 945711000797 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 945711000798 Domain of unknown function (DUF955); Region: DUF955; pfam06114 945711000799 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 945711000800 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 945711000801 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 945711000802 putative Iron-sulfur protein interface [polypeptide binding]; other site 945711000803 proximal heme binding site [chemical binding]; other site 945711000804 distal heme binding site [chemical binding]; other site 945711000805 putative dimer interface [polypeptide binding]; other site 945711000806 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 945711000807 L-aspartate oxidase; Provisional; Region: PRK06175 945711000808 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 945711000809 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 945711000810 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 945711000811 Predicted membrane protein [Function unknown]; Region: COG2733 945711000812 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 945711000813 Class I aldolases; Region: Aldolase_Class_I; cl17187 945711000814 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 945711000815 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 945711000816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711000817 FeS/SAM binding site; other site 945711000818 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 945711000819 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 945711000820 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 945711000821 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 945711000822 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 945711000823 FAD binding domain; Region: FAD_binding_4; pfam01565 945711000824 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 945711000825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 945711000826 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 945711000827 acyl-activating enzyme (AAE) consensus motif; other site 945711000828 putative AMP binding site [chemical binding]; other site 945711000829 putative active site [active] 945711000830 putative CoA binding site [chemical binding]; other site 945711000831 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 945711000832 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 945711000833 putative ADP-binding pocket [chemical binding]; other site 945711000834 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711000835 catalytic core [active] 945711000836 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711000837 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945711000838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945711000839 dimer interface [polypeptide binding]; other site 945711000840 phosphorylation site [posttranslational modification] 945711000841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711000842 ATP binding site [chemical binding]; other site 945711000843 Mg2+ binding site [ion binding]; other site 945711000844 G-X-G motif; other site 945711000845 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945711000846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711000847 active site 945711000848 phosphorylation site [posttranslational modification] 945711000849 intermolecular recognition site; other site 945711000850 dimerization interface [polypeptide binding]; other site 945711000851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945711000852 DNA binding site [nucleotide binding] 945711000853 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 945711000854 exopolyphosphatase; Region: exo_poly_only; TIGR03706 945711000855 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 945711000856 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 945711000857 pyrroline-5-carboxylate reductase; Region: PLN02688 945711000858 DNA binding domain, excisionase family; Region: excise; TIGR01764 945711000859 Thioredoxin; Region: Thioredoxin_4; pfam13462 945711000860 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 945711000861 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 945711000862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711000863 motif II; other site 945711000864 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 945711000865 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 945711000866 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 945711000867 tRNA; other site 945711000868 putative tRNA binding site [nucleotide binding]; other site 945711000869 putative NADP binding site [chemical binding]; other site 945711000870 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 945711000871 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 945711000872 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 945711000873 domain interfaces; other site 945711000874 active site 945711000875 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 945711000876 active site 945711000877 homodimer interface [polypeptide binding]; other site 945711000878 SAM binding site [chemical binding]; other site 945711000879 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 945711000880 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 945711000881 active site 945711000882 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 945711000883 dimer interface [polypeptide binding]; other site 945711000884 active site 945711000885 Schiff base residues; other site 945711000886 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945711000887 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 945711000888 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 945711000889 substrate binding site [chemical binding]; other site 945711000890 active site 945711000891 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 945711000892 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 945711000893 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 945711000894 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 945711000895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945711000896 inhibitor-cofactor binding pocket; inhibition site 945711000897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711000898 catalytic residue [active] 945711000899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711000900 catalytic core [active] 945711000901 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 945711000902 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945711000903 catalytic residues [active] 945711000904 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 945711000905 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 945711000906 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 945711000907 ResB-like family; Region: ResB; pfam05140 945711000908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945711000909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945711000910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711000911 S-adenosylmethionine binding site [chemical binding]; other site 945711000912 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711000913 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711000914 Walker A/P-loop; other site 945711000915 ATP binding site [chemical binding]; other site 945711000916 Q-loop/lid; other site 945711000917 ABC transporter signature motif; other site 945711000918 Walker B; other site 945711000919 D-loop; other site 945711000920 H-loop/switch region; other site 945711000921 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 945711000922 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711000923 intersubunit interface [polypeptide binding]; other site 945711000924 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711000925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711000926 ABC-ATPase subunit interface; other site 945711000927 dimer interface [polypeptide binding]; other site 945711000928 putative PBP binding regions; other site 945711000929 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 945711000930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945711000931 dimerization interface [polypeptide binding]; other site 945711000932 putative DNA binding site [nucleotide binding]; other site 945711000933 putative Zn2+ binding site [ion binding]; other site 945711000934 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 945711000935 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 945711000936 UbiA prenyltransferase family; Region: UbiA; pfam01040 945711000937 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 945711000938 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945711000939 acyl-activating enzyme (AAE) consensus motif; other site 945711000940 AMP binding site [chemical binding]; other site 945711000941 active site 945711000942 CoA binding site [chemical binding]; other site 945711000943 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 945711000944 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 945711000945 substrate binding site [chemical binding]; other site 945711000946 oxyanion hole (OAH) forming residues; other site 945711000947 trimer interface [polypeptide binding]; other site 945711000948 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 945711000949 oligomer interface [polypeptide binding]; other site 945711000950 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 945711000951 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 945711000952 O-succinylbenzoate synthase; Provisional; Region: PRK02901 945711000953 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 945711000954 active site 945711000955 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 945711000956 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 945711000957 dimer interface [polypeptide binding]; other site 945711000958 tetramer interface [polypeptide binding]; other site 945711000959 PYR/PP interface [polypeptide binding]; other site 945711000960 TPP binding site [chemical binding]; other site 945711000961 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 945711000962 TPP-binding site; other site 945711000963 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 945711000964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945711000965 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 945711000966 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 945711000967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711000968 S-adenosylmethionine binding site [chemical binding]; other site 945711000969 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 945711000970 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 945711000971 NAD(P) binding site [chemical binding]; other site 945711000972 LDH/MDH dimer interface [polypeptide binding]; other site 945711000973 substrate binding site [chemical binding]; other site 945711000974 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 945711000975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945711000976 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 945711000977 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 945711000978 substrate binding pocket [chemical binding]; other site 945711000979 chain length determination region; other site 945711000980 substrate-Mg2+ binding site; other site 945711000981 catalytic residues [active] 945711000982 aspartate-rich region 1; other site 945711000983 active site lid residues [active] 945711000984 aspartate-rich region 2; other site 945711000985 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 945711000986 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 945711000987 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 945711000988 putative homodimer interface [polypeptide binding]; other site 945711000989 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 945711000990 heterodimer interface [polypeptide binding]; other site 945711000991 homodimer interface [polypeptide binding]; other site 945711000992 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 945711000993 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 945711000994 23S rRNA interface [nucleotide binding]; other site 945711000995 L7/L12 interface [polypeptide binding]; other site 945711000996 putative thiostrepton binding site; other site 945711000997 L25 interface [polypeptide binding]; other site 945711000998 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 945711000999 mRNA/rRNA interface [nucleotide binding]; other site 945711001000 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 945711001001 trimer interface [polypeptide binding]; other site 945711001002 active site 945711001003 G bulge; other site 945711001004 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 945711001005 trimer interface [polypeptide binding]; other site 945711001006 active site 945711001007 G bulge; other site 945711001008 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 945711001009 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 945711001010 FMN binding site [chemical binding]; other site 945711001011 active site 945711001012 substrate binding site [chemical binding]; other site 945711001013 catalytic residue [active] 945711001014 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 945711001015 23S rRNA interface [nucleotide binding]; other site 945711001016 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 945711001017 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 945711001018 L11 interface [polypeptide binding]; other site 945711001019 putative EF-Tu interaction site [polypeptide binding]; other site 945711001020 putative EF-G interaction site [polypeptide binding]; other site 945711001021 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 945711001022 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711001023 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 945711001024 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711001025 intersubunit interface [polypeptide binding]; other site 945711001026 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711001027 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711001028 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711001029 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 945711001030 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 945711001031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 945711001032 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 945711001033 putative PBP binding regions; other site 945711001034 ABC-ATPase subunit interface; other site 945711001035 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 945711001036 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 945711001037 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 945711001038 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 945711001039 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 945711001040 RPB1 interaction site [polypeptide binding]; other site 945711001041 RPB10 interaction site [polypeptide binding]; other site 945711001042 RPB11 interaction site [polypeptide binding]; other site 945711001043 RPB3 interaction site [polypeptide binding]; other site 945711001044 RPB12 interaction site [polypeptide binding]; other site 945711001045 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 945711001046 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 945711001047 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 945711001048 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 945711001049 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 945711001050 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 945711001051 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 945711001052 G-loop; other site 945711001053 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 945711001054 DNA binding site [nucleotide binding] 945711001055 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 945711001056 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 945711001057 TQXA domain; Region: TQXA_dom; TIGR03934 945711001058 Histidine kinase; Region: HisKA_3; pfam07730 945711001059 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 945711001060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711001061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711001062 active site 945711001063 phosphorylation site [posttranslational modification] 945711001064 intermolecular recognition site; other site 945711001065 dimerization interface [polypeptide binding]; other site 945711001066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711001067 DNA binding residues [nucleotide binding] 945711001068 dimerization interface [polypeptide binding]; other site 945711001069 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711001070 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 945711001071 Walker A/P-loop; other site 945711001072 ATP binding site [chemical binding]; other site 945711001073 Q-loop/lid; other site 945711001074 ABC transporter signature motif; other site 945711001075 Walker B; other site 945711001076 D-loop; other site 945711001077 H-loop/switch region; other site 945711001078 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 945711001079 TIGR03943 family protein; Region: TIGR03943 945711001080 Predicted permease; Region: DUF318; cl17795 945711001081 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 945711001082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711001083 FeS/SAM binding site; other site 945711001084 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 945711001085 Class III ribonucleotide reductase; Region: RNR_III; cd01675 945711001086 effector binding site; other site 945711001087 active site 945711001088 Zn binding site [ion binding]; other site 945711001089 glycine loop; other site 945711001090 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 945711001091 S17 interaction site [polypeptide binding]; other site 945711001092 S8 interaction site; other site 945711001093 16S rRNA interaction site [nucleotide binding]; other site 945711001094 streptomycin interaction site [chemical binding]; other site 945711001095 23S rRNA interaction site [nucleotide binding]; other site 945711001096 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 945711001097 30S ribosomal protein S7; Validated; Region: PRK05302 945711001098 elongation factor G; Reviewed; Region: PRK00007 945711001099 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 945711001100 G1 box; other site 945711001101 putative GEF interaction site [polypeptide binding]; other site 945711001102 GTP/Mg2+ binding site [chemical binding]; other site 945711001103 Switch I region; other site 945711001104 G2 box; other site 945711001105 G3 box; other site 945711001106 Switch II region; other site 945711001107 G4 box; other site 945711001108 G5 box; other site 945711001109 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 945711001110 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 945711001111 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 945711001112 elongation factor Tu; Reviewed; Region: PRK00049 945711001113 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 945711001114 G1 box; other site 945711001115 GEF interaction site [polypeptide binding]; other site 945711001116 GTP/Mg2+ binding site [chemical binding]; other site 945711001117 Switch I region; other site 945711001118 G2 box; other site 945711001119 G3 box; other site 945711001120 Switch II region; other site 945711001121 G4 box; other site 945711001122 G5 box; other site 945711001123 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 945711001124 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 945711001125 Antibiotic Binding Site [chemical binding]; other site 945711001126 Predicted membrane protein [Function unknown]; Region: COG2323 945711001127 Asp23 family; Region: Asp23; cl00574 945711001128 Asp23 family; Region: Asp23; cl00574 945711001129 Asp23 family; Region: Asp23; pfam03780 945711001130 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 945711001131 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 945711001132 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 945711001133 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 945711001134 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 945711001135 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 945711001136 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 945711001137 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 945711001138 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 945711001139 putative translocon binding site; other site 945711001140 protein-rRNA interface [nucleotide binding]; other site 945711001141 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 945711001142 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 945711001143 G-X-X-G motif; other site 945711001144 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 945711001145 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 945711001146 23S rRNA interface [nucleotide binding]; other site 945711001147 5S rRNA interface [nucleotide binding]; other site 945711001148 putative antibiotic binding site [chemical binding]; other site 945711001149 L25 interface [polypeptide binding]; other site 945711001150 L27 interface [polypeptide binding]; other site 945711001151 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 945711001152 putative translocon interaction site; other site 945711001153 23S rRNA interface [nucleotide binding]; other site 945711001154 signal recognition particle (SRP54) interaction site; other site 945711001155 L23 interface [polypeptide binding]; other site 945711001156 trigger factor interaction site; other site 945711001157 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 945711001158 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 945711001159 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 945711001160 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 945711001161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711001162 Walker A/P-loop; other site 945711001163 ATP binding site [chemical binding]; other site 945711001164 Q-loop/lid; other site 945711001165 ABC transporter signature motif; other site 945711001166 Walker B; other site 945711001167 D-loop; other site 945711001168 H-loop/switch region; other site 945711001169 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711001170 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711001171 Walker A/P-loop; other site 945711001172 ATP binding site [chemical binding]; other site 945711001173 Q-loop/lid; other site 945711001174 ABC transporter signature motif; other site 945711001175 Walker B; other site 945711001176 D-loop; other site 945711001177 H-loop/switch region; other site 945711001178 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711001179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711001180 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 945711001181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001182 dimer interface [polypeptide binding]; other site 945711001183 conserved gate region; other site 945711001184 putative PBP binding loops; other site 945711001185 ABC-ATPase subunit interface; other site 945711001186 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001188 dimer interface [polypeptide binding]; other site 945711001189 conserved gate region; other site 945711001190 putative PBP binding loops; other site 945711001191 ABC-ATPase subunit interface; other site 945711001192 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 945711001193 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 945711001194 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 945711001195 RNA binding site [nucleotide binding]; other site 945711001196 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 945711001197 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 945711001198 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 945711001199 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 945711001200 serine transporter; Region: stp; TIGR00814 945711001201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 945711001202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 945711001203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 945711001204 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 945711001205 active site 945711001206 homotetramer interface [polypeptide binding]; other site 945711001207 homodimer interface [polypeptide binding]; other site 945711001208 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 945711001209 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945711001210 active site 945711001211 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 945711001212 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 945711001213 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 945711001214 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 945711001215 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 945711001216 5S rRNA interface [nucleotide binding]; other site 945711001217 23S rRNA interface [nucleotide binding]; other site 945711001218 L5 interface [polypeptide binding]; other site 945711001219 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 945711001220 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 945711001221 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 945711001222 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 945711001223 23S rRNA binding site [nucleotide binding]; other site 945711001224 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 945711001225 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 945711001226 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 945711001227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001228 dimer interface [polypeptide binding]; other site 945711001229 conserved gate region; other site 945711001230 putative PBP binding loops; other site 945711001231 ABC-ATPase subunit interface; other site 945711001232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 945711001233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001234 dimer interface [polypeptide binding]; other site 945711001235 conserved gate region; other site 945711001236 putative PBP binding loops; other site 945711001237 ABC-ATPase subunit interface; other site 945711001238 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 945711001239 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 945711001240 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 945711001241 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 945711001242 Walker A/P-loop; other site 945711001243 ATP binding site [chemical binding]; other site 945711001244 Q-loop/lid; other site 945711001245 ABC transporter signature motif; other site 945711001246 Walker B; other site 945711001247 D-loop; other site 945711001248 H-loop/switch region; other site 945711001249 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 945711001250 SecY translocase; Region: SecY; pfam00344 945711001251 adenylate kinase; Reviewed; Region: adk; PRK00279 945711001252 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 945711001253 AMP-binding site [chemical binding]; other site 945711001254 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 945711001255 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 945711001256 active site 945711001257 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 945711001258 catalytic site [active] 945711001259 Asp-box motif; other site 945711001260 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 945711001261 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 945711001262 rRNA binding site [nucleotide binding]; other site 945711001263 predicted 30S ribosome binding site; other site 945711001264 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 945711001265 30S ribosomal protein S13; Region: bact_S13; TIGR03631 945711001266 30S ribosomal protein S11; Validated; Region: PRK05309 945711001267 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 945711001268 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 945711001269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711001270 RNA binding surface [nucleotide binding]; other site 945711001271 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 945711001272 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 945711001273 alphaNTD - beta interaction site [polypeptide binding]; other site 945711001274 alphaNTD homodimer interface [polypeptide binding]; other site 945711001275 alphaNTD - beta' interaction site [polypeptide binding]; other site 945711001276 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 945711001277 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 945711001278 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 945711001279 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 945711001280 dimerization interface 3.5A [polypeptide binding]; other site 945711001281 active site 945711001282 Protein of unknown function (DUF690); Region: DUF690; cl04939 945711001283 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 945711001284 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 945711001285 active site 945711001286 catalytic residues [active] 945711001287 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 945711001288 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 945711001289 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 945711001290 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 945711001291 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 945711001292 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 945711001293 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 945711001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 945711001295 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 945711001296 23S rRNA interface [nucleotide binding]; other site 945711001297 L3 interface [polypeptide binding]; other site 945711001298 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 945711001299 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 945711001300 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 945711001301 active site 945711001302 substrate binding site [chemical binding]; other site 945711001303 metal binding site [ion binding]; metal-binding site 945711001304 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 945711001305 alanine racemase; Reviewed; Region: alr; PRK00053 945711001306 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 945711001307 active site 945711001308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945711001309 dimer interface [polypeptide binding]; other site 945711001310 substrate binding site [chemical binding]; other site 945711001311 catalytic residues [active] 945711001312 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 945711001313 Predicted permease [General function prediction only]; Region: COG2985 945711001314 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 945711001315 TrkA-C domain; Region: TrkA_C; pfam02080 945711001316 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 945711001317 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 945711001318 Glycoprotease family; Region: Peptidase_M22; pfam00814 945711001319 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 945711001320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945711001321 Coenzyme A binding pocket [chemical binding]; other site 945711001322 UGMP family protein; Validated; Region: PRK09604 945711001323 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 945711001324 oligomerisation interface [polypeptide binding]; other site 945711001325 mobile loop; other site 945711001326 roof hairpin; other site 945711001327 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 945711001328 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 945711001329 ring oligomerisation interface [polypeptide binding]; other site 945711001330 ATP/Mg binding site [chemical binding]; other site 945711001331 stacking interactions; other site 945711001332 hinge regions; other site 945711001333 Transcription factor WhiB; Region: Whib; pfam02467 945711001334 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 945711001335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711001336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711001337 DNA binding residues [nucleotide binding] 945711001338 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 945711001339 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 945711001340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 945711001341 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 945711001342 active site 945711001343 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 945711001344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 945711001345 phosphate binding site [ion binding]; other site 945711001346 Amino acid permease; Region: AA_permease_2; pfam13520 945711001347 GMP synthase; Reviewed; Region: guaA; PRK00074 945711001348 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 945711001349 AMP/PPi binding site [chemical binding]; other site 945711001350 candidate oxyanion hole; other site 945711001351 catalytic triad [active] 945711001352 potential glutamine specificity residues [chemical binding]; other site 945711001353 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 945711001354 ATP Binding subdomain [chemical binding]; other site 945711001355 Ligand Binding sites [chemical binding]; other site 945711001356 Dimerization subdomain; other site 945711001357 PspC domain; Region: PspC; cl00864 945711001358 PspC domain; Region: PspC; pfam04024 945711001359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945711001360 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 945711001361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711001362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711001363 active site 945711001364 phosphorylation site [posttranslational modification] 945711001365 intermolecular recognition site; other site 945711001366 dimerization interface [polypeptide binding]; other site 945711001367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711001368 dimerization interface [polypeptide binding]; other site 945711001369 DNA binding residues [nucleotide binding] 945711001370 AMIN domain; Region: AMIN; pfam11741 945711001371 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 945711001372 putative dimer interface [polypeptide binding]; other site 945711001373 putative [2Fe-2S] cluster binding site [ion binding]; other site 945711001374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001375 dimer interface [polypeptide binding]; other site 945711001376 conserved gate region; other site 945711001377 ABC-ATPase subunit interface; other site 945711001378 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 945711001379 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 945711001380 Walker A/P-loop; other site 945711001381 ATP binding site [chemical binding]; other site 945711001382 Q-loop/lid; other site 945711001383 ABC transporter signature motif; other site 945711001384 Walker B; other site 945711001385 D-loop; other site 945711001386 H-loop/switch region; other site 945711001387 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 945711001388 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 945711001389 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 945711001390 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 945711001391 Uncharacterized conserved protein [Function unknown]; Region: COG3402 945711001392 Predicted membrane protein [Function unknown]; Region: COG3428 945711001393 Bacterial PH domain; Region: DUF304; pfam03703 945711001394 Bacterial PH domain; Region: DUF304; cl01348 945711001395 Bacterial PH domain; Region: DUF304; pfam03703 945711001396 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711001397 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 945711001398 intersubunit interface [polypeptide binding]; other site 945711001399 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 945711001400 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 945711001401 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 945711001402 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711001403 ABC-ATPase subunit interface; other site 945711001404 dimer interface [polypeptide binding]; other site 945711001405 putative PBP binding regions; other site 945711001406 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 945711001407 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 945711001408 ABC-ATPase subunit interface; other site 945711001409 dimer interface [polypeptide binding]; other site 945711001410 putative PBP binding regions; other site 945711001411 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 945711001412 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 945711001413 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 945711001414 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 945711001415 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 945711001416 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 945711001417 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 945711001418 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 945711001419 homodimer interface [polypeptide binding]; other site 945711001420 NADP binding site [chemical binding]; other site 945711001421 substrate binding site [chemical binding]; other site 945711001422 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 945711001423 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945711001424 active site 945711001425 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 945711001426 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 945711001427 Htaa; Region: HtaA; pfam04213 945711001428 Htaa; Region: HtaA; pfam04213 945711001429 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 945711001430 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711001431 intersubunit interface [polypeptide binding]; other site 945711001432 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 945711001433 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711001434 ABC-ATPase subunit interface; other site 945711001435 dimer interface [polypeptide binding]; other site 945711001436 putative PBP binding regions; other site 945711001437 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 945711001438 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711001439 Walker A/P-loop; other site 945711001440 ATP binding site [chemical binding]; other site 945711001441 Q-loop/lid; other site 945711001442 ABC transporter signature motif; other site 945711001443 Walker B; other site 945711001444 D-loop; other site 945711001445 H-loop/switch region; other site 945711001446 Htaa; Region: HtaA; pfam04213 945711001447 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 945711001448 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 945711001449 homodimer interface [polypeptide binding]; other site 945711001450 substrate-cofactor binding pocket; other site 945711001451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711001452 catalytic residue [active] 945711001453 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 945711001454 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 945711001455 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 945711001456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711001457 putative substrate translocation pore; other site 945711001458 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 945711001459 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945711001460 DNA binding residues [nucleotide binding] 945711001461 dimer interface [polypeptide binding]; other site 945711001462 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 945711001463 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 945711001464 putative catalytic site [active] 945711001465 putative metal binding site [ion binding]; other site 945711001466 putative phosphate binding site [ion binding]; other site 945711001467 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 945711001468 active site 945711001469 substrate binding sites [chemical binding]; other site 945711001470 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 945711001471 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 945711001472 active site 945711001473 HIGH motif; other site 945711001474 dimer interface [polypeptide binding]; other site 945711001475 KMSKS motif; other site 945711001476 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 945711001477 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 945711001478 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 945711001479 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 945711001480 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945711001481 NlpC/P60 family; Region: NLPC_P60; pfam00877 945711001482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711001483 active site 945711001484 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 945711001485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 945711001486 non-specific DNA binding site [nucleotide binding]; other site 945711001487 salt bridge; other site 945711001488 sequence-specific DNA binding site [nucleotide binding]; other site 945711001489 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 945711001490 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 945711001491 active site 945711001492 substrate binding site [chemical binding]; other site 945711001493 metal binding site [ion binding]; metal-binding site 945711001494 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 945711001495 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 945711001496 metal binding site [ion binding]; metal-binding site 945711001497 putative dimer interface [polypeptide binding]; other site 945711001498 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 945711001499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945711001500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945711001501 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 945711001502 pyruvate carboxylase; Reviewed; Region: PRK12999 945711001503 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945711001504 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945711001505 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 945711001506 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 945711001507 active site 945711001508 catalytic residues [active] 945711001509 metal binding site [ion binding]; metal-binding site 945711001510 homodimer binding site [polypeptide binding]; other site 945711001511 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945711001512 carboxyltransferase (CT) interaction site; other site 945711001513 biotinylation site [posttranslational modification]; other site 945711001514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711001515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711001516 putative substrate translocation pore; other site 945711001517 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 945711001518 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945711001519 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 945711001520 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 945711001521 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945711001522 carboxyltransferase (CT) interaction site; other site 945711001523 biotinylation site [posttranslational modification]; other site 945711001524 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 945711001525 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 945711001526 active site residue [active] 945711001527 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 945711001528 active site residue [active] 945711001529 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 945711001530 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 945711001531 Maf-like protein; Region: Maf; pfam02545 945711001532 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 945711001533 active site 945711001534 dimer interface [polypeptide binding]; other site 945711001535 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 945711001536 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 945711001537 substrate binding site [chemical binding]; other site 945711001538 dimer interface [polypeptide binding]; other site 945711001539 ATP binding site [chemical binding]; other site 945711001540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 945711001541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 945711001542 DNA binding site [nucleotide binding] 945711001543 domain linker motif; other site 945711001544 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 945711001545 putative ligand binding site [chemical binding]; other site 945711001546 dimerization interface [polypeptide binding]; other site 945711001547 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 945711001548 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 945711001549 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945711001550 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945711001551 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 945711001552 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945711001553 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945711001554 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 945711001555 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 945711001556 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711001557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711001558 Walker A/P-loop; other site 945711001559 ATP binding site [chemical binding]; other site 945711001560 Q-loop/lid; other site 945711001561 ABC transporter signature motif; other site 945711001562 Walker B; other site 945711001563 D-loop; other site 945711001564 H-loop/switch region; other site 945711001565 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 945711001566 ATP-grasp domain; Region: ATP-grasp; pfam02222 945711001567 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 945711001568 Uncharacterized conserved protein [Function unknown]; Region: COG1434 945711001569 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 945711001570 putative active site [active] 945711001571 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 945711001572 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711001573 intersubunit interface [polypeptide binding]; other site 945711001574 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711001575 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711001576 ABC-ATPase subunit interface; other site 945711001577 dimer interface [polypeptide binding]; other site 945711001578 putative PBP binding regions; other site 945711001579 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711001580 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711001581 Walker A/P-loop; other site 945711001582 ATP binding site [chemical binding]; other site 945711001583 Q-loop/lid; other site 945711001584 ABC transporter signature motif; other site 945711001585 Walker B; other site 945711001586 D-loop; other site 945711001587 H-loop/switch region; other site 945711001588 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 945711001589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001590 dimer interface [polypeptide binding]; other site 945711001591 conserved gate region; other site 945711001592 putative PBP binding loops; other site 945711001593 ABC-ATPase subunit interface; other site 945711001594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001595 dimer interface [polypeptide binding]; other site 945711001596 conserved gate region; other site 945711001597 putative PBP binding loops; other site 945711001598 ABC-ATPase subunit interface; other site 945711001599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 945711001600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 945711001601 TIGR03089 family protein; Region: TIGR03089 945711001602 Transcriptional regulator [Transcription]; Region: LytR; COG1316 945711001603 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 945711001604 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945711001605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945711001606 active site 945711001607 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945711001608 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 945711001609 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 945711001610 active site 945711001611 Substrate binding site; other site 945711001612 Mg++ binding site; other site 945711001613 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 945711001614 Transcription factor WhiB; Region: Whib; pfam02467 945711001615 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 945711001616 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 945711001617 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 945711001618 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 945711001619 active site 945711001620 substrate binding site [chemical binding]; other site 945711001621 metal binding site [ion binding]; metal-binding site 945711001622 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 945711001623 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 945711001624 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 945711001626 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 945711001627 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 945711001628 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 945711001629 homotetramer interface [polypeptide binding]; other site 945711001630 ligand binding site [chemical binding]; other site 945711001631 catalytic site [active] 945711001632 NAD binding site [chemical binding]; other site 945711001633 thymidylate kinase; Validated; Region: PRK07933 945711001634 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 945711001635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945711001636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711001637 active site 945711001638 phosphorylation site [posttranslational modification] 945711001639 intermolecular recognition site; other site 945711001640 dimerization interface [polypeptide binding]; other site 945711001641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945711001642 DNA binding site [nucleotide binding] 945711001643 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 945711001644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945711001645 dimerization interface [polypeptide binding]; other site 945711001646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945711001647 dimer interface [polypeptide binding]; other site 945711001648 phosphorylation site [posttranslational modification] 945711001649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711001650 ATP binding site [chemical binding]; other site 945711001651 Mg2+ binding site [ion binding]; other site 945711001652 G-X-G motif; other site 945711001653 lipoprotein LpqB; Provisional; Region: PRK13616 945711001654 Sporulation and spore germination; Region: Germane; pfam10646 945711001655 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 945711001656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711001657 active site 945711001658 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 945711001659 30S subunit binding site; other site 945711001660 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 945711001661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 945711001662 ATP binding site [chemical binding]; other site 945711001663 putative Mg++ binding site [ion binding]; other site 945711001664 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 945711001665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 945711001666 nucleotide binding region [chemical binding]; other site 945711001667 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 945711001668 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 945711001669 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 945711001670 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 945711001671 FAD binding pocket [chemical binding]; other site 945711001672 FAD binding motif [chemical binding]; other site 945711001673 phosphate binding motif [ion binding]; other site 945711001674 beta-alpha-beta structure motif; other site 945711001675 NAD binding pocket [chemical binding]; other site 945711001676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 945711001677 catalytic loop [active] 945711001678 iron binding site [ion binding]; other site 945711001679 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 945711001680 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 945711001681 putative di-iron ligands [ion binding]; other site 945711001682 Predicted GTPases [General function prediction only]; Region: COG1162 945711001683 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 945711001684 GTPase/Zn-binding domain interface [polypeptide binding]; other site 945711001685 GTP/Mg2+ binding site [chemical binding]; other site 945711001686 G4 box; other site 945711001687 G5 box; other site 945711001688 G1 box; other site 945711001689 Switch I region; other site 945711001690 G2 box; other site 945711001691 G3 box; other site 945711001692 Switch II region; other site 945711001693 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 945711001694 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 945711001695 hinge; other site 945711001696 active site 945711001697 Uncharacterized conserved protein [Function unknown]; Region: COG2135 945711001698 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 945711001699 putative deacylase active site [active] 945711001700 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 945711001701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711001702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711001703 DNA binding residues [nucleotide binding] 945711001704 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 945711001705 Transcription factor WhiB; Region: Whib; pfam02467 945711001706 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 945711001707 active site 945711001708 catalytic triad [active] 945711001709 oxyanion hole [active] 945711001710 PQQ-like domain; Region: PQQ_2; pfam13360 945711001711 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 945711001712 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945711001713 ATP binding site [chemical binding]; other site 945711001714 Mg++ binding site [ion binding]; other site 945711001715 motif III; other site 945711001716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711001717 nucleotide binding region [chemical binding]; other site 945711001718 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 945711001719 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 945711001720 TIGR02569 family protein; Region: TIGR02569_actnb 945711001721 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 945711001722 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 945711001723 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 945711001724 Part of AAA domain; Region: AAA_19; pfam13245 945711001725 Family description; Region: UvrD_C_2; pfam13538 945711001726 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 945711001727 Ion channel; Region: Ion_trans_2; pfam07885 945711001728 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 945711001729 TrkA-N domain; Region: TrkA_N; pfam02254 945711001730 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 945711001731 putative NADH binding site [chemical binding]; other site 945711001732 putative active site [active] 945711001733 nudix motif; other site 945711001734 putative metal binding site [ion binding]; other site 945711001735 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 945711001736 Part of AAA domain; Region: AAA_19; pfam13245 945711001737 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 945711001738 Family description; Region: UvrD_C_2; pfam13538 945711001739 HRDC domain; Region: HRDC; pfam00570 945711001740 Protein of unknown function DUF45; Region: DUF45; cl00636 945711001741 putative hydrolase; Region: TIGR03624 945711001742 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 945711001743 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 945711001744 hypothetical protein; Validated; Region: PRK00068 945711001745 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 945711001746 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 945711001747 pentamer interface [polypeptide binding]; other site 945711001748 dodecaamer interface [polypeptide binding]; other site 945711001749 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 945711001750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945711001751 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 945711001752 acyl-activating enzyme (AAE) consensus motif; other site 945711001753 AMP binding site [chemical binding]; other site 945711001754 active site 945711001755 CoA binding site [chemical binding]; other site 945711001756 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 945711001757 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 945711001758 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945711001759 putative trimer interface [polypeptide binding]; other site 945711001760 putative CoA binding site [chemical binding]; other site 945711001761 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945711001762 putative trimer interface [polypeptide binding]; other site 945711001763 putative CoA binding site [chemical binding]; other site 945711001764 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 945711001765 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 945711001766 oxaloacetate decarboxylase; Provisional; Region: PRK12330 945711001767 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 945711001768 active site 945711001769 catalytic residues [active] 945711001770 metal binding site [ion binding]; metal-binding site 945711001771 homodimer binding site [polypeptide binding]; other site 945711001772 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 945711001773 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945711001774 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945711001775 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945711001776 carboxyltransferase (CT) interaction site; other site 945711001777 biotinylation site [posttranslational modification]; other site 945711001778 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945711001779 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 945711001780 active site 945711001781 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 945711001782 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945711001783 active site 945711001784 peptide chain release factor 2; Validated; Region: prfB; PRK00578 945711001785 This domain is found in peptide chain release factors; Region: PCRF; smart00937 945711001786 RF-1 domain; Region: RF-1; pfam00472 945711001787 AAA domain; Region: AAA_17; pfam13207 945711001788 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 945711001789 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 945711001790 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 945711001791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711001792 Walker A/P-loop; other site 945711001793 ATP binding site [chemical binding]; other site 945711001794 Q-loop/lid; other site 945711001795 ABC transporter signature motif; other site 945711001796 Walker B; other site 945711001797 D-loop; other site 945711001798 H-loop/switch region; other site 945711001799 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 945711001800 FtsX-like permease family; Region: FtsX; pfam02687 945711001801 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 945711001802 SmpB-tmRNA interface; other site 945711001803 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 945711001804 active site clefts [active] 945711001805 zinc binding site [ion binding]; other site 945711001806 dimer interface [polypeptide binding]; other site 945711001807 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 945711001808 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711001809 intersubunit interface [polypeptide binding]; other site 945711001810 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711001811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711001812 ABC-ATPase subunit interface; other site 945711001813 dimer interface [polypeptide binding]; other site 945711001814 putative PBP binding regions; other site 945711001815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711001816 ABC-ATPase subunit interface; other site 945711001817 dimer interface [polypeptide binding]; other site 945711001818 putative PBP binding regions; other site 945711001819 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 945711001820 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711001821 Walker A/P-loop; other site 945711001822 ATP binding site [chemical binding]; other site 945711001823 Q-loop/lid; other site 945711001824 ABC transporter signature motif; other site 945711001825 Walker B; other site 945711001826 D-loop; other site 945711001827 H-loop/switch region; other site 945711001828 aminotransferase; Validated; Region: PRK07777 945711001829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711001830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711001831 homodimer interface [polypeptide binding]; other site 945711001832 catalytic residue [active] 945711001833 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 945711001834 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 945711001835 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 945711001836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711001837 ATP binding site [chemical binding]; other site 945711001838 putative Mg++ binding site [ion binding]; other site 945711001839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711001840 nucleotide binding region [chemical binding]; other site 945711001841 ATP-binding site [chemical binding]; other site 945711001842 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 945711001843 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 945711001844 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 945711001845 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 945711001846 DNA-binding site [nucleotide binding]; DNA binding site 945711001847 RNA-binding motif; other site 945711001848 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 945711001849 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 945711001850 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 945711001851 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 945711001852 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 945711001853 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945711001854 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 945711001855 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 945711001856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945711001857 catalytic residue [active] 945711001858 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 945711001859 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 945711001860 dimer interface [polypeptide binding]; other site 945711001861 active site 945711001862 citrylCoA binding site [chemical binding]; other site 945711001863 NADH binding [chemical binding]; other site 945711001864 cationic pore residues; other site 945711001865 oxalacetate/citrate binding site [chemical binding]; other site 945711001866 coenzyme A binding site [chemical binding]; other site 945711001867 catalytic triad [active] 945711001868 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 945711001869 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 945711001870 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945711001871 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945711001872 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 945711001873 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 945711001874 E-class dimer interface [polypeptide binding]; other site 945711001875 P-class dimer interface [polypeptide binding]; other site 945711001876 active site 945711001877 Cu2+ binding site [ion binding]; other site 945711001878 Zn2+ binding site [ion binding]; other site 945711001879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945711001880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945711001881 active site 945711001882 catalytic tetrad [active] 945711001883 enoyl-CoA hydratase; Provisional; Region: PRK06688 945711001884 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 945711001885 substrate binding site [chemical binding]; other site 945711001886 oxyanion hole (OAH) forming residues; other site 945711001887 trimer interface [polypeptide binding]; other site 945711001888 Protein of unknown function, DUF485; Region: DUF485; pfam04341 945711001889 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 945711001890 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 945711001891 Na binding site [ion binding]; other site 945711001892 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 945711001893 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 945711001894 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 945711001895 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 945711001896 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 945711001897 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 945711001898 multidrug efflux protein NorA; Provisional; Region: PRK00187 945711001899 cation binding site [ion binding]; other site 945711001900 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 945711001901 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 945711001902 dimer interface [polypeptide binding]; other site 945711001903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711001904 catalytic residue [active] 945711001905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 945711001906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945711001907 catalytic residue [active] 945711001908 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 945711001909 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 945711001910 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 945711001911 substrate binding pocket [chemical binding]; other site 945711001912 active site 945711001913 iron coordination sites [ion binding]; other site 945711001914 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 945711001915 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 945711001916 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711001917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711001918 dimer interface [polypeptide binding]; other site 945711001919 conserved gate region; other site 945711001920 putative PBP binding loops; other site 945711001921 ABC-ATPase subunit interface; other site 945711001922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711001923 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 945711001924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711001925 Walker A/P-loop; other site 945711001926 ATP binding site [chemical binding]; other site 945711001927 Q-loop/lid; other site 945711001928 ABC transporter signature motif; other site 945711001929 Walker B; other site 945711001930 D-loop; other site 945711001931 H-loop/switch region; other site 945711001932 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711001933 Walker A/P-loop; other site 945711001934 ATP binding site [chemical binding]; other site 945711001935 Q-loop/lid; other site 945711001936 ABC transporter signature motif; other site 945711001937 Walker B; other site 945711001938 D-loop; other site 945711001939 H-loop/switch region; other site 945711001940 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 945711001941 active site 945711001942 SAM binding site [chemical binding]; other site 945711001943 homodimer interface [polypeptide binding]; other site 945711001944 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 945711001945 catalytic residues [active] 945711001946 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 945711001947 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 945711001948 folate binding site [chemical binding]; other site 945711001949 NADP+ binding site [chemical binding]; other site 945711001950 thymidylate synthase; Reviewed; Region: thyA; PRK01827 945711001951 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 945711001952 dimerization interface [polypeptide binding]; other site 945711001953 active site 945711001954 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 945711001955 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945711001956 active site 945711001957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711001958 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 945711001959 ATP binding site [chemical binding]; other site 945711001960 putative Mg++ binding site [ion binding]; other site 945711001961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711001962 nucleotide binding region [chemical binding]; other site 945711001963 ATP-binding site [chemical binding]; other site 945711001964 DEAD/H associated; Region: DEAD_assoc; pfam08494 945711001965 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 945711001966 active site 945711001967 SUMO-1 interface [polypeptide binding]; other site 945711001968 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 945711001969 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 945711001970 putative DNA binding site [nucleotide binding]; other site 945711001971 catalytic residue [active] 945711001972 putative H2TH interface [polypeptide binding]; other site 945711001973 putative catalytic residues [active] 945711001974 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 945711001975 hypothetical protein; Provisional; Region: PRK11770 945711001976 Domain of unknown function (DUF307); Region: DUF307; pfam03733 945711001977 Domain of unknown function (DUF307); Region: DUF307; pfam03733 945711001978 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 945711001979 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 945711001980 active site 945711001981 dimer interface [polypeptide binding]; other site 945711001982 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 945711001983 dimer interface [polypeptide binding]; other site 945711001984 active site 945711001985 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 945711001986 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 945711001987 tetramerization interface [polypeptide binding]; other site 945711001988 NAD(P) binding site [chemical binding]; other site 945711001989 catalytic residues [active] 945711001990 hypothetical protein; Provisional; Region: PRK07857 945711001991 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 945711001992 Part of AAA domain; Region: AAA_19; pfam13245 945711001993 Family description; Region: UvrD_C_2; pfam13538 945711001994 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 945711001995 Peptidase family M23; Region: Peptidase_M23; pfam01551 945711001996 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 945711001997 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 945711001998 active site 945711001999 substrate binding site [chemical binding]; other site 945711002000 cosubstrate binding site; other site 945711002001 catalytic site [active] 945711002002 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 945711002003 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 945711002004 purine monophosphate binding site [chemical binding]; other site 945711002005 dimer interface [polypeptide binding]; other site 945711002006 putative catalytic residues [active] 945711002007 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 945711002008 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 945711002009 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 945711002010 Walker A/P-loop; other site 945711002011 ATP binding site [chemical binding]; other site 945711002012 Q-loop/lid; other site 945711002013 ABC transporter signature motif; other site 945711002014 Walker B; other site 945711002015 D-loop; other site 945711002016 H-loop/switch region; other site 945711002017 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 945711002018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 945711002019 substrate binding pocket [chemical binding]; other site 945711002020 membrane-bound complex binding site; other site 945711002021 hinge residues; other site 945711002022 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 945711002023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002024 dimer interface [polypeptide binding]; other site 945711002025 conserved gate region; other site 945711002026 putative PBP binding loops; other site 945711002027 ABC-ATPase subunit interface; other site 945711002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002029 dimer interface [polypeptide binding]; other site 945711002030 conserved gate region; other site 945711002031 putative PBP binding loops; other site 945711002032 ABC-ATPase subunit interface; other site 945711002033 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 945711002034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711002035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711002036 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 945711002037 30S ribosomal protein S18; Provisional; Region: PRK13401 945711002038 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 945711002039 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 945711002040 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 945711002041 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 945711002042 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 945711002043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945711002044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711002045 active site 945711002046 phosphorylation site [posttranslational modification] 945711002047 intermolecular recognition site; other site 945711002048 dimerization interface [polypeptide binding]; other site 945711002049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945711002050 DNA binding site [nucleotide binding] 945711002051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945711002052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945711002053 dimerization interface [polypeptide binding]; other site 945711002054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945711002055 dimer interface [polypeptide binding]; other site 945711002056 phosphorylation site [posttranslational modification] 945711002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711002058 ATP binding site [chemical binding]; other site 945711002059 Mg2+ binding site [ion binding]; other site 945711002060 G-X-G motif; other site 945711002061 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945711002062 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 945711002063 protein binding site [polypeptide binding]; other site 945711002064 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 945711002065 MPT binding site; other site 945711002066 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 945711002067 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 945711002068 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 945711002069 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 945711002070 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 945711002071 active site 945711002072 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 945711002073 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 945711002074 dimer interface [polypeptide binding]; other site 945711002075 putative functional site; other site 945711002076 putative MPT binding site; other site 945711002077 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 945711002078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 945711002079 Coenzyme A binding pocket [chemical binding]; other site 945711002080 Predicted membrane protein [Function unknown]; Region: COG2259 945711002081 Predicted integral membrane protein [Function unknown]; Region: COG5660 945711002082 Putative zinc-finger; Region: zf-HC2; pfam13490 945711002083 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 945711002084 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 945711002085 BCCT family transporter; Region: BCCT; pfam02028 945711002086 Uncharacterized membrane protein [Function unknown]; Region: COG3949 945711002087 Predicted methyltransferases [General function prediction only]; Region: COG0313 945711002088 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 945711002089 putative SAM binding site [chemical binding]; other site 945711002090 putative homodimer interface [polypeptide binding]; other site 945711002091 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 945711002092 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 945711002093 active site 945711002094 HIGH motif; other site 945711002095 KMSKS motif; other site 945711002096 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 945711002097 tRNA binding surface [nucleotide binding]; other site 945711002098 anticodon binding site; other site 945711002099 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 945711002100 active site 945711002101 Domain of unknown function (DUF348); Region: DUF348; pfam03990 945711002102 Domain of unknown function (DUF348); Region: DUF348; pfam03990 945711002103 G5 domain; Region: G5; pfam07501 945711002104 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 945711002105 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 945711002106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711002107 S-adenosylmethionine binding site [chemical binding]; other site 945711002108 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 945711002109 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 945711002110 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 945711002111 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711002112 ABC transporter; Region: ABC_tran_2; pfam12848 945711002113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711002114 Uncharacterized conserved protein [Function unknown]; Region: COG1359 945711002115 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 945711002116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711002117 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 945711002118 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 945711002119 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 945711002120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711002121 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 945711002122 active site 945711002123 motif I; other site 945711002124 motif II; other site 945711002125 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 945711002126 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 945711002127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 945711002128 substrate binding site [chemical binding]; other site 945711002129 oxyanion hole (OAH) forming residues; other site 945711002130 trimer interface [polypeptide binding]; other site 945711002131 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 945711002132 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 945711002133 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 945711002134 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 945711002135 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 945711002136 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 945711002137 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 945711002138 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 945711002139 G1 box; other site 945711002140 putative GEF interaction site [polypeptide binding]; other site 945711002141 GTP/Mg2+ binding site [chemical binding]; other site 945711002142 Switch I region; other site 945711002143 G2 box; other site 945711002144 G3 box; other site 945711002145 Switch II region; other site 945711002146 G4 box; other site 945711002147 G5 box; other site 945711002148 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 945711002149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711002150 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 945711002151 NAD(P) binding site [chemical binding]; other site 945711002152 active site 945711002153 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 945711002154 putative active site [active] 945711002155 catalytic residue [active] 945711002156 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 945711002157 FMN binding site [chemical binding]; other site 945711002158 substrate binding site [chemical binding]; other site 945711002159 putative catalytic residue [active] 945711002160 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 945711002161 putative active site [active] 945711002162 catalytic residue [active] 945711002163 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 945711002164 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 945711002165 5S rRNA interface [nucleotide binding]; other site 945711002166 CTC domain interface [polypeptide binding]; other site 945711002167 L16 interface [polypeptide binding]; other site 945711002168 pullulanase, type I; Region: pulA_typeI; TIGR02104 945711002169 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 945711002170 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 945711002171 Ca binding site [ion binding]; other site 945711002172 active site 945711002173 catalytic site [active] 945711002174 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 945711002175 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 945711002176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711002177 active site 945711002178 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 945711002179 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 945711002180 Substrate binding site; other site 945711002181 Mg++ binding site; other site 945711002182 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 945711002183 active site 945711002184 substrate binding site [chemical binding]; other site 945711002185 CoA binding site [chemical binding]; other site 945711002186 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 945711002187 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 945711002188 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 945711002189 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 945711002190 gating phenylalanine in ion channel; other site 945711002191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711002192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711002193 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 945711002194 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 945711002195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711002196 ATP binding site [chemical binding]; other site 945711002197 putative Mg++ binding site [ion binding]; other site 945711002198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711002199 nucleotide binding region [chemical binding]; other site 945711002200 ATP-binding site [chemical binding]; other site 945711002201 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 945711002202 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 945711002203 Spore germination protein; Region: Spore_permease; cl17796 945711002204 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 945711002205 homodimer interface [polypeptide binding]; other site 945711002206 metal binding site [ion binding]; metal-binding site 945711002207 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 945711002208 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 945711002209 N-acetyl-D-glucosamine binding site [chemical binding]; other site 945711002210 enolase; Provisional; Region: eno; PRK00077 945711002211 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 945711002212 dimer interface [polypeptide binding]; other site 945711002213 metal binding site [ion binding]; metal-binding site 945711002214 substrate binding pocket [chemical binding]; other site 945711002215 Septum formation initiator; Region: DivIC; pfam04977 945711002216 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 945711002217 Uncharacterized conserved protein [Function unknown]; Region: COG1507 945711002218 exopolyphosphatase; Region: exo_poly_only; TIGR03706 945711002219 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 945711002220 Helix-turn-helix domain; Region: HTH_18; pfam12833 945711002221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 945711002222 Bax inhibitor 1 like; Region: BaxI_1; cl17691 945711002223 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 945711002224 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 945711002225 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 945711002226 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 945711002227 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 945711002228 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 945711002229 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 945711002230 catalytic residue [active] 945711002231 putative FPP diphosphate binding site; other site 945711002232 putative FPP binding hydrophobic cleft; other site 945711002233 dimer interface [polypeptide binding]; other site 945711002234 putative IPP diphosphate binding site; other site 945711002235 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 945711002236 pantothenate kinase; Provisional; Region: PRK05439 945711002237 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 945711002238 ATP-binding site [chemical binding]; other site 945711002239 CoA-binding site [chemical binding]; other site 945711002240 Mg2+-binding site [ion binding]; other site 945711002241 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 945711002242 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 945711002243 dimer interface [polypeptide binding]; other site 945711002244 active site 945711002245 glycine-pyridoxal phosphate binding site [chemical binding]; other site 945711002246 folate binding site [chemical binding]; other site 945711002247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711002248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711002249 putative substrate translocation pore; other site 945711002250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711002251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 945711002252 dimerization interface [polypeptide binding]; other site 945711002253 Transcriptional regulator [Transcription]; Region: LysR; COG0583 945711002254 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 945711002255 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 945711002256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945711002257 Coenzyme A binding pocket [chemical binding]; other site 945711002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711002259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711002260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711002261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711002262 fumarate hydratase; Reviewed; Region: fumC; PRK00485 945711002263 Class II fumarases; Region: Fumarase_classII; cd01362 945711002264 active site 945711002265 tetramer interface [polypeptide binding]; other site 945711002266 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 945711002267 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 945711002268 putative active site [active] 945711002269 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 945711002270 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 945711002271 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 945711002272 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 945711002273 generic binding surface II; other site 945711002274 generic binding surface I; other site 945711002275 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 945711002276 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 945711002277 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 945711002278 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 945711002279 Domain of unknown function DUF20; Region: UPF0118; pfam01594 945711002280 GTP-binding protein YchF; Reviewed; Region: PRK09601 945711002281 YchF GTPase; Region: YchF; cd01900 945711002282 G1 box; other site 945711002283 GTP/Mg2+ binding site [chemical binding]; other site 945711002284 Switch I region; other site 945711002285 G2 box; other site 945711002286 Switch II region; other site 945711002287 G3 box; other site 945711002288 G4 box; other site 945711002289 G5 box; other site 945711002290 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 945711002291 Alkylmercury lyase; Region: MerB; pfam03243 945711002292 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 945711002293 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 945711002294 PhnA protein; Region: PhnA; pfam03831 945711002295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945711002296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945711002297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002298 Walker A/P-loop; other site 945711002299 ATP binding site [chemical binding]; other site 945711002300 Q-loop/lid; other site 945711002301 ABC transporter signature motif; other site 945711002302 Walker B; other site 945711002303 D-loop; other site 945711002304 H-loop/switch region; other site 945711002305 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 945711002306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002307 Walker A/P-loop; other site 945711002308 ATP binding site [chemical binding]; other site 945711002309 Q-loop/lid; other site 945711002310 ABC transporter signature motif; other site 945711002311 Walker B; other site 945711002312 D-loop; other site 945711002313 H-loop/switch region; other site 945711002314 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 945711002315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002316 Walker A/P-loop; other site 945711002317 ATP binding site [chemical binding]; other site 945711002318 Q-loop/lid; other site 945711002319 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945711002320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002321 Walker A/P-loop; other site 945711002322 ATP binding site [chemical binding]; other site 945711002323 Q-loop/lid; other site 945711002324 ABC transporter signature motif; other site 945711002325 Walker B; other site 945711002326 D-loop; other site 945711002327 H-loop/switch region; other site 945711002328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 945711002329 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 945711002330 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 945711002331 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 945711002332 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 945711002333 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 945711002334 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 945711002335 Walker A/P-loop; other site 945711002336 ATP binding site [chemical binding]; other site 945711002337 Q-loop/lid; other site 945711002338 ABC transporter signature motif; other site 945711002339 Walker B; other site 945711002340 D-loop; other site 945711002341 H-loop/switch region; other site 945711002342 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 945711002343 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 945711002344 Q-loop/lid; other site 945711002345 ABC transporter signature motif; other site 945711002346 Walker B; other site 945711002347 D-loop; other site 945711002348 H-loop/switch region; other site 945711002349 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 945711002350 hypothetical protein; Provisional; Region: PRK06547 945711002351 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 945711002352 nudix motif; other site 945711002353 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 945711002354 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 945711002355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711002356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002357 dimer interface [polypeptide binding]; other site 945711002358 conserved gate region; other site 945711002359 ABC-ATPase subunit interface; other site 945711002360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711002361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002362 dimer interface [polypeptide binding]; other site 945711002363 conserved gate region; other site 945711002364 putative PBP binding loops; other site 945711002365 ABC-ATPase subunit interface; other site 945711002366 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 945711002367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711002368 Walker A/P-loop; other site 945711002369 ATP binding site [chemical binding]; other site 945711002370 Q-loop/lid; other site 945711002371 ABC transporter signature motif; other site 945711002372 Walker B; other site 945711002373 D-loop; other site 945711002374 H-loop/switch region; other site 945711002375 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711002376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711002377 Walker A/P-loop; other site 945711002378 ATP binding site [chemical binding]; other site 945711002379 Q-loop/lid; other site 945711002380 ABC transporter signature motif; other site 945711002381 Walker B; other site 945711002382 D-loop; other site 945711002383 H-loop/switch region; other site 945711002384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711002385 Predicted transcriptional regulators [Transcription]; Region: COG1695 945711002386 Transcriptional regulator PadR-like family; Region: PadR; cl17335 945711002387 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711002388 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945711002389 Walker A/P-loop; other site 945711002390 ATP binding site [chemical binding]; other site 945711002391 Q-loop/lid; other site 945711002392 ABC transporter signature motif; other site 945711002393 Walker B; other site 945711002394 D-loop; other site 945711002395 H-loop/switch region; other site 945711002396 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 945711002397 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 945711002398 cleavage site 945711002399 active site 945711002400 substrate binding sites [chemical binding]; other site 945711002401 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 945711002402 ArsC family; Region: ArsC; pfam03960 945711002403 catalytic residues [active] 945711002404 Protein of unknown function (DUF402); Region: DUF402; cl00979 945711002405 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 945711002406 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 945711002407 G1 box; other site 945711002408 GTP/Mg2+ binding site [chemical binding]; other site 945711002409 G2 box; other site 945711002410 Switch I region; other site 945711002411 G3 box; other site 945711002412 Switch II region; other site 945711002413 G4 box; other site 945711002414 G5 box; other site 945711002415 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 945711002416 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 945711002417 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 945711002418 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 945711002419 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 945711002420 Ferredoxin [Energy production and conversion]; Region: COG1146 945711002421 4Fe-4S binding domain; Region: Fer4; pfam00037 945711002422 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 945711002423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711002424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711002425 homodimer interface [polypeptide binding]; other site 945711002426 catalytic residue [active] 945711002427 Predicted membrane protein [Function unknown]; Region: COG2246 945711002428 GtrA-like protein; Region: GtrA; pfam04138 945711002429 Domain of unknown function (DUF222); Region: DUF222; pfam02720 945711002430 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945711002431 active site 945711002432 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 945711002433 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 945711002434 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 945711002435 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 945711002436 putative trimer interface [polypeptide binding]; other site 945711002437 putative CoA binding site [chemical binding]; other site 945711002438 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 945711002439 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 945711002440 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 945711002441 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945711002442 putative trimer interface [polypeptide binding]; other site 945711002443 putative CoA binding site [chemical binding]; other site 945711002444 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 945711002445 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 945711002446 metal binding site [ion binding]; metal-binding site 945711002447 putative dimer interface [polypeptide binding]; other site 945711002448 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 945711002449 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 945711002450 dihydropteroate synthase; Region: DHPS; TIGR01496 945711002451 substrate binding pocket [chemical binding]; other site 945711002452 dimer interface [polypeptide binding]; other site 945711002453 inhibitor binding site; inhibition site 945711002454 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945711002455 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 945711002456 Ligand binding site; other site 945711002457 Putative Catalytic site; other site 945711002458 DXD motif; other site 945711002459 DivIVA domain; Region: DivI1A_domain; TIGR03544 945711002460 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 945711002461 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 945711002462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711002463 S-adenosylmethionine binding site [chemical binding]; other site 945711002464 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 945711002465 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 945711002466 active site 945711002467 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 945711002468 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 945711002469 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 945711002470 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945711002471 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 945711002472 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 945711002473 ligand binding site; other site 945711002474 oligomer interface; other site 945711002475 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 945711002476 dimer interface [polypeptide binding]; other site 945711002477 N-terminal domain interface [polypeptide binding]; other site 945711002478 sulfate 1 binding site; other site 945711002479 Methyltransferase domain; Region: Methyltransf_24; pfam13578 945711002480 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 945711002481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711002482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711002483 DNA binding residues [nucleotide binding] 945711002484 sec-independent translocase; Provisional; Region: tatB; PRK00182 945711002485 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 945711002486 antiporter inner membrane protein; Provisional; Region: PRK11670 945711002487 Domain of unknown function DUF59; Region: DUF59; pfam01883 945711002488 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 945711002489 Predicted membrane protein [Function unknown]; Region: COG4420 945711002490 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 945711002491 MgtE intracellular N domain; Region: MgtE_N; smart00924 945711002492 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 945711002493 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 945711002494 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 945711002495 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 945711002496 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 945711002497 TPP-binding site [chemical binding]; other site 945711002498 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 945711002499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945711002500 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945711002501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002502 Walker A/P-loop; other site 945711002503 ATP binding site [chemical binding]; other site 945711002504 Q-loop/lid; other site 945711002505 ABC transporter signature motif; other site 945711002506 Walker B; other site 945711002507 D-loop; other site 945711002508 H-loop/switch region; other site 945711002509 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945711002510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945711002511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002512 Walker A/P-loop; other site 945711002513 ATP binding site [chemical binding]; other site 945711002514 Q-loop/lid; other site 945711002515 ABC transporter signature motif; other site 945711002516 Walker B; other site 945711002517 D-loop; other site 945711002518 H-loop/switch region; other site 945711002519 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 945711002520 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 945711002521 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 945711002522 shikimate binding site; other site 945711002523 NAD(P) binding site [chemical binding]; other site 945711002524 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 945711002525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 945711002526 substrate binding pocket [chemical binding]; other site 945711002527 catalytic triad [active] 945711002528 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 945711002529 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 945711002530 active site 945711002531 catalytic residues [active] 945711002532 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 945711002533 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 945711002534 Na binding site [ion binding]; other site 945711002535 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 945711002536 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 945711002537 nucleotide binding site/active site [active] 945711002538 HIT family signature motif; other site 945711002539 catalytic residue [active] 945711002540 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 945711002541 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 945711002542 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 945711002543 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 945711002544 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 945711002545 ATP binding site [chemical binding]; other site 945711002546 Mg++ binding site [ion binding]; other site 945711002547 motif III; other site 945711002548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711002549 nucleotide binding region [chemical binding]; other site 945711002550 ATP-binding site [chemical binding]; other site 945711002551 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 945711002552 putative RNA binding site [nucleotide binding]; other site 945711002553 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 945711002554 dimer interface [polypeptide binding]; other site 945711002555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945711002556 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 945711002557 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 945711002558 Na binding site [ion binding]; other site 945711002559 SNF2 Helicase protein; Region: DUF3670; pfam12419 945711002560 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 945711002561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711002562 ATP binding site [chemical binding]; other site 945711002563 putative Mg++ binding site [ion binding]; other site 945711002564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711002565 nucleotide binding region [chemical binding]; other site 945711002566 ATP-binding site [chemical binding]; other site 945711002567 Uncharacterized conserved protein [Function unknown]; Region: COG4279 945711002568 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 945711002569 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 945711002570 active site 945711002571 metal binding site [ion binding]; metal-binding site 945711002572 DNA binding site [nucleotide binding] 945711002573 AAA domain; Region: AAA_23; pfam13476 945711002574 Uncharacterized conserved protein [Function unknown]; Region: COG2353 945711002575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945711002576 MarR family; Region: MarR_2; pfam12802 945711002577 PspC domain; Region: PspC; pfam04024 945711002578 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 945711002579 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 945711002580 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 945711002581 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 945711002582 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 945711002583 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 945711002584 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 945711002585 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 945711002586 Cysteine-rich domain; Region: CCG; pfam02754 945711002587 Cysteine-rich domain; Region: CCG; pfam02754 945711002588 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 945711002589 L-lactate permease; Region: Lactate_perm; cl00701 945711002590 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 945711002591 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 945711002592 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 945711002593 active site 945711002594 HIGH motif; other site 945711002595 KMSK motif region; other site 945711002596 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 945711002597 tRNA binding surface [nucleotide binding]; other site 945711002598 anticodon binding site; other site 945711002599 diaminopimelate decarboxylase; Region: lysA; TIGR01048 945711002600 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 945711002601 active site 945711002602 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945711002603 substrate binding site [chemical binding]; other site 945711002604 catalytic residues [active] 945711002605 dimer interface [polypeptide binding]; other site 945711002606 homoserine dehydrogenase; Provisional; Region: PRK06349 945711002607 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 945711002608 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 945711002609 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 945711002610 homoserine kinase; Provisional; Region: PRK01212 945711002611 Predicted transcriptional regulator [Transcription]; Region: COG2345 945711002612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 945711002613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945711002614 acyl-activating enzyme (AAE) consensus motif; other site 945711002615 AMP binding site [chemical binding]; other site 945711002616 active site 945711002617 CoA binding site [chemical binding]; other site 945711002618 transcription termination factor Rho; Provisional; Region: PRK12678 945711002619 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 945711002620 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945711002621 RNA binding site [nucleotide binding]; other site 945711002622 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 945711002623 multimer interface [polypeptide binding]; other site 945711002624 Walker A motif; other site 945711002625 ATP binding site [chemical binding]; other site 945711002626 Walker B motif; other site 945711002627 peptide chain release factor 1; Validated; Region: prfA; PRK00591 945711002628 This domain is found in peptide chain release factors; Region: PCRF; smart00937 945711002629 RF-1 domain; Region: RF-1; pfam00472 945711002630 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 945711002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711002632 S-adenosylmethionine binding site [chemical binding]; other site 945711002633 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 945711002634 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 945711002635 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 945711002636 Mg++ binding site [ion binding]; other site 945711002637 putative catalytic motif [active] 945711002638 substrate binding site [chemical binding]; other site 945711002639 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 945711002640 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 945711002641 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 945711002642 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 945711002643 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 945711002644 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 945711002645 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 945711002646 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 945711002647 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 945711002648 beta subunit interaction interface [polypeptide binding]; other site 945711002649 Walker A motif; other site 945711002650 ATP binding site [chemical binding]; other site 945711002651 Walker B motif; other site 945711002652 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 945711002653 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 945711002654 core domain interface [polypeptide binding]; other site 945711002655 delta subunit interface [polypeptide binding]; other site 945711002656 epsilon subunit interface [polypeptide binding]; other site 945711002657 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 945711002658 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 945711002659 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 945711002660 alpha subunit interaction interface [polypeptide binding]; other site 945711002661 Walker A motif; other site 945711002662 ATP binding site [chemical binding]; other site 945711002663 Walker B motif; other site 945711002664 inhibitor binding site; inhibition site 945711002665 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 945711002666 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 945711002667 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 945711002668 gamma subunit interface [polypeptide binding]; other site 945711002669 epsilon subunit interface [polypeptide binding]; other site 945711002670 LBP interface [polypeptide binding]; other site 945711002671 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 945711002672 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 945711002673 hypothetical protein; Provisional; Region: PRK03298 945711002674 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 945711002675 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945711002676 dimer interface [polypeptide binding]; other site 945711002677 substrate binding site [chemical binding]; other site 945711002678 metal binding site [ion binding]; metal-binding site 945711002679 Domain of unknown function DUF77; Region: DUF77; pfam01910 945711002680 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 945711002681 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 945711002682 glycogen branching enzyme; Provisional; Region: PRK05402 945711002683 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 945711002684 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 945711002685 active site 945711002686 catalytic site [active] 945711002687 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 945711002688 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 945711002689 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 945711002690 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945711002691 active site 945711002692 catalytic site [active] 945711002693 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 945711002694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711002695 Walker A/P-loop; other site 945711002696 ATP binding site [chemical binding]; other site 945711002697 ABC transporter signature motif; other site 945711002698 Walker B; other site 945711002699 D-loop; other site 945711002700 H-loop/switch region; other site 945711002701 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 945711002702 Ligand binding site [chemical binding]; other site 945711002703 Electron transfer flavoprotein domain; Region: ETF; pfam01012 945711002704 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 945711002705 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 945711002706 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 945711002707 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 945711002708 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 945711002709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945711002710 catalytic residue [active] 945711002711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711002712 S-adenosylmethionine binding site [chemical binding]; other site 945711002713 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 945711002714 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 945711002715 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 945711002716 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 945711002717 active site 945711002718 catalytic site [active] 945711002719 substrate binding site [chemical binding]; other site 945711002720 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 945711002721 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 945711002722 nucleotide binding pocket [chemical binding]; other site 945711002723 K-X-D-G motif; other site 945711002724 catalytic site [active] 945711002725 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 945711002726 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 945711002727 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 945711002728 Dimer interface [polypeptide binding]; other site 945711002729 BRCT sequence motif; other site 945711002730 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 945711002731 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 945711002732 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 945711002733 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 945711002734 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 945711002735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945711002736 Coenzyme A binding pocket [chemical binding]; other site 945711002737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711002738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711002739 putative substrate translocation pore; other site 945711002740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711002741 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711002742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711002743 ABC-ATPase subunit interface; other site 945711002744 dimer interface [polypeptide binding]; other site 945711002745 putative PBP binding regions; other site 945711002746 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711002747 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711002748 Walker A/P-loop; other site 945711002749 ATP binding site [chemical binding]; other site 945711002750 Q-loop/lid; other site 945711002751 ABC transporter signature motif; other site 945711002752 Walker B; other site 945711002753 D-loop; other site 945711002754 H-loop/switch region; other site 945711002755 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 945711002756 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 945711002757 putative ligand binding residues [chemical binding]; other site 945711002758 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 945711002759 phosphofructokinase; Region: PFK_mixed; TIGR02483 945711002760 active site 945711002761 ADP/pyrophosphate binding site [chemical binding]; other site 945711002762 dimerization interface [polypeptide binding]; other site 945711002763 allosteric effector site; other site 945711002764 fructose-1,6-bisphosphate binding site; other site 945711002765 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 945711002766 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 945711002767 GatB domain; Region: GatB_Yqey; smart00845 945711002768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945711002769 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945711002770 active site 945711002771 catalytic tetrad [active] 945711002772 Lysine efflux permease [General function prediction only]; Region: COG1279 945711002773 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 945711002774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 945711002775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 945711002776 dimerization interface [polypeptide binding]; other site 945711002777 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 945711002778 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 945711002779 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 945711002780 putative dimer interface [polypeptide binding]; other site 945711002781 N-terminal domain interface [polypeptide binding]; other site 945711002782 putative substrate binding pocket (H-site) [chemical binding]; other site 945711002783 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 945711002784 Predicted membrane protein [Function unknown]; Region: COG2259 945711002785 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 945711002786 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 945711002787 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 945711002788 Mechanosensitive ion channel; Region: MS_channel; pfam00924 945711002789 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 945711002790 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 945711002791 PYR/PP interface [polypeptide binding]; other site 945711002792 dimer interface [polypeptide binding]; other site 945711002793 TPP binding site [chemical binding]; other site 945711002794 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 945711002795 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 945711002796 TPP-binding site [chemical binding]; other site 945711002797 dimer interface [polypeptide binding]; other site 945711002798 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 945711002799 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 945711002800 putative valine binding site [chemical binding]; other site 945711002801 dimer interface [polypeptide binding]; other site 945711002802 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 945711002803 ketol-acid reductoisomerase; Provisional; Region: PRK05479 945711002804 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 945711002805 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 945711002806 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 945711002807 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 945711002808 Uncharacterized conserved protein [Function unknown]; Region: COG1479 945711002809 Protein of unknown function DUF262; Region: DUF262; pfam03235 945711002810 Uncharacterized conserved protein [Function unknown]; Region: COG3472 945711002811 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 945711002812 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 945711002813 ligand binding site [chemical binding]; other site 945711002814 NAD binding site [chemical binding]; other site 945711002815 dimerization interface [polypeptide binding]; other site 945711002816 catalytic site [active] 945711002817 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 945711002818 putative L-serine binding site [chemical binding]; other site 945711002819 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 945711002820 tartrate dehydrogenase; Region: TTC; TIGR02089 945711002821 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 945711002822 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945711002823 ligand binding site [chemical binding]; other site 945711002824 flexible hinge region; other site 945711002825 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 945711002826 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945711002827 metal binding triad; other site 945711002828 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 945711002829 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 945711002830 active site 945711002831 catalytic site [active] 945711002832 substrate binding site [chemical binding]; other site 945711002833 hypothetical protein; Provisional; Region: PRK06771 945711002834 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 945711002835 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 945711002836 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 945711002837 Methyltransferase domain; Region: Methyltransf_23; pfam13489 945711002838 Methyltransferase domain; Region: Methyltransf_18; pfam12847 945711002839 S-adenosylmethionine binding site [chemical binding]; other site 945711002840 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 945711002841 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 945711002842 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 945711002843 active site 945711002844 HIGH motif; other site 945711002845 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 945711002846 active site 945711002847 KMSKS motif; other site 945711002848 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 945711002849 Cutinase; Region: Cutinase; pfam01083 945711002850 H+ Antiporter protein; Region: 2A0121; TIGR00900 945711002851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711002852 putative substrate translocation pore; other site 945711002853 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 945711002854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711002855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002856 dimer interface [polypeptide binding]; other site 945711002857 conserved gate region; other site 945711002858 putative PBP binding loops; other site 945711002859 ABC-ATPase subunit interface; other site 945711002860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711002861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002862 dimer interface [polypeptide binding]; other site 945711002863 conserved gate region; other site 945711002864 putative PBP binding loops; other site 945711002865 ABC-ATPase subunit interface; other site 945711002866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711002867 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711002868 Walker A/P-loop; other site 945711002869 ATP binding site [chemical binding]; other site 945711002870 Q-loop/lid; other site 945711002871 ABC transporter signature motif; other site 945711002872 Walker B; other site 945711002873 D-loop; other site 945711002874 H-loop/switch region; other site 945711002875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 945711002876 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711002877 Walker A/P-loop; other site 945711002878 ATP binding site [chemical binding]; other site 945711002879 Q-loop/lid; other site 945711002880 ABC transporter signature motif; other site 945711002881 Walker B; other site 945711002882 D-loop; other site 945711002883 H-loop/switch region; other site 945711002884 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 945711002885 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 945711002886 biotin synthase; Region: bioB; TIGR00433 945711002887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711002888 FeS/SAM binding site; other site 945711002889 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 945711002890 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 945711002891 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945711002892 Zn2+ binding site [ion binding]; other site 945711002893 Mg2+ binding site [ion binding]; other site 945711002894 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 945711002895 Transcriptional regulator [Transcription]; Region: IclR; COG1414 945711002896 Bacterial transcriptional regulator; Region: IclR; pfam01614 945711002897 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 945711002898 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 945711002899 substrate binding site [chemical binding]; other site 945711002900 ligand binding site [chemical binding]; other site 945711002901 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 945711002902 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 945711002903 substrate binding site [chemical binding]; other site 945711002904 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 945711002905 active site 945711002906 Ap6A binding site [chemical binding]; other site 945711002907 nudix motif; other site 945711002908 metal binding site [ion binding]; metal-binding site 945711002909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711002910 catalytic core [active] 945711002911 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 945711002912 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 945711002913 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 945711002914 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 945711002915 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 945711002916 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945711002917 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 945711002918 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 945711002919 thiamine monophosphate kinase; Provisional; Region: PRK05731 945711002920 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 945711002921 ATP binding site [chemical binding]; other site 945711002922 dimerization interface [polypeptide binding]; other site 945711002923 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 945711002924 ligand binding site [chemical binding]; other site 945711002925 active site 945711002926 UGI interface [polypeptide binding]; other site 945711002927 catalytic site [active] 945711002928 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 945711002929 DAK2 domain; Region: Dak2; pfam02734 945711002930 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 945711002931 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 945711002932 generic binding surface II; other site 945711002933 ssDNA binding site; other site 945711002934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711002935 ATP binding site [chemical binding]; other site 945711002936 putative Mg++ binding site [ion binding]; other site 945711002937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711002938 nucleotide binding region [chemical binding]; other site 945711002939 ATP-binding site [chemical binding]; other site 945711002940 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 945711002941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945711002942 carboxyltransferase (CT) interaction site; other site 945711002943 biotinylation site [posttranslational modification]; other site 945711002944 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 945711002945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711002946 S-adenosylmethionine binding site [chemical binding]; other site 945711002947 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 945711002948 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 945711002949 active site 945711002950 (T/H)XGH motif; other site 945711002951 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 945711002952 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 945711002953 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 945711002954 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 945711002955 Walker A/P-loop; other site 945711002956 ATP binding site [chemical binding]; other site 945711002957 Q-loop/lid; other site 945711002958 ABC transporter signature motif; other site 945711002959 Walker B; other site 945711002960 D-loop; other site 945711002961 H-loop/switch region; other site 945711002962 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711002963 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 945711002964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711002965 dimer interface [polypeptide binding]; other site 945711002966 conserved gate region; other site 945711002967 putative PBP binding loops; other site 945711002968 ABC-ATPase subunit interface; other site 945711002969 Membrane-associated tegument protein; Region: UL11; cl17374 945711002970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 945711002971 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 945711002972 substrate binding pocket [chemical binding]; other site 945711002973 membrane-bound complex binding site; other site 945711002974 hinge residues; other site 945711002975 Domain of unknown function (DUF368); Region: DUF368; pfam04018 945711002976 DNA polymerase I; Provisional; Region: PRK05755 945711002977 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 945711002978 active site 945711002979 metal binding site 1 [ion binding]; metal-binding site 945711002980 putative 5' ssDNA interaction site; other site 945711002981 metal binding site 3; metal-binding site 945711002982 metal binding site 2 [ion binding]; metal-binding site 945711002983 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 945711002984 putative DNA binding site [nucleotide binding]; other site 945711002985 putative metal binding site [ion binding]; other site 945711002986 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 945711002987 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 945711002988 active site 945711002989 DNA binding site [nucleotide binding] 945711002990 catalytic site [active] 945711002991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945711002992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711002993 S-adenosylmethionine binding site [chemical binding]; other site 945711002994 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 945711002995 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 945711002996 RNA binding site [nucleotide binding]; other site 945711002997 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 945711002998 RNA binding site [nucleotide binding]; other site 945711002999 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945711003000 RNA binding site [nucleotide binding]; other site 945711003001 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 945711003002 RNA binding site [nucleotide binding]; other site 945711003003 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 945711003004 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 945711003005 active site turn [active] 945711003006 phosphorylation site [posttranslational modification] 945711003007 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 945711003008 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 945711003009 HPr interaction site; other site 945711003010 glycerol kinase (GK) interaction site [polypeptide binding]; other site 945711003011 active site 945711003012 phosphorylation site [posttranslational modification] 945711003013 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 945711003014 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 945711003015 CoA-binding site [chemical binding]; other site 945711003016 ATP-binding [chemical binding]; other site 945711003017 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 945711003018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711003019 FeS/SAM binding site; other site 945711003020 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 945711003021 excinuclease ABC subunit B; Provisional; Region: PRK05298 945711003022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711003023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711003024 nucleotide binding region [chemical binding]; other site 945711003025 ATP-binding site [chemical binding]; other site 945711003026 Ultra-violet resistance protein B; Region: UvrB; pfam12344 945711003027 UvrB/uvrC motif; Region: UVR; pfam02151 945711003028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711003029 Ligand Binding Site [chemical binding]; other site 945711003030 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 945711003031 Part of AAA domain; Region: AAA_19; pfam13245 945711003032 PhoH-like protein; Region: PhoH; cl17668 945711003033 Predicted membrane protein [Function unknown]; Region: COG2259 945711003034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 945711003035 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 945711003036 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945711003037 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945711003038 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 945711003039 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 945711003040 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 945711003041 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 945711003042 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 945711003043 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 945711003044 23S rRNA binding site [nucleotide binding]; other site 945711003045 L21 binding site [polypeptide binding]; other site 945711003046 L13 binding site [polypeptide binding]; other site 945711003047 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 945711003048 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 945711003049 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 945711003050 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945711003051 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 945711003052 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 945711003053 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 945711003054 dimer interface [polypeptide binding]; other site 945711003055 motif 1; other site 945711003056 active site 945711003057 motif 2; other site 945711003058 motif 3; other site 945711003059 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 945711003060 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 945711003061 putative tRNA-binding site [nucleotide binding]; other site 945711003062 B3/4 domain; Region: B3_4; pfam03483 945711003063 tRNA synthetase B5 domain; Region: B5; smart00874 945711003064 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 945711003065 dimer interface [polypeptide binding]; other site 945711003066 motif 1; other site 945711003067 motif 3; other site 945711003068 motif 2; other site 945711003069 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 945711003070 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 945711003071 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 945711003072 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 945711003073 heterotetramer interface [polypeptide binding]; other site 945711003074 active site pocket [active] 945711003075 cleavage site 945711003076 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 945711003077 feedback inhibition sensing region; other site 945711003078 homohexameric interface [polypeptide binding]; other site 945711003079 nucleotide binding site [chemical binding]; other site 945711003080 N-acetyl-L-glutamate binding site [chemical binding]; other site 945711003081 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 945711003082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945711003083 inhibitor-cofactor binding pocket; inhibition site 945711003084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711003085 catalytic residue [active] 945711003086 ornithine carbamoyltransferase; Provisional; Region: PRK00779 945711003087 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 945711003088 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 945711003089 arginine repressor; Provisional; Region: PRK03341 945711003090 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 945711003091 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 945711003092 argininosuccinate synthase; Provisional; Region: PRK13820 945711003093 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 945711003094 ANP binding site [chemical binding]; other site 945711003095 Substrate Binding Site II [chemical binding]; other site 945711003096 Substrate Binding Site I [chemical binding]; other site 945711003097 argininosuccinate lyase; Provisional; Region: PRK00855 945711003098 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 945711003099 active sites [active] 945711003100 tetramer interface [polypeptide binding]; other site 945711003101 Uncharacterized conserved protein [Function unknown]; Region: COG2835 945711003102 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 945711003103 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 945711003104 active site 945711003105 HIGH motif; other site 945711003106 dimer interface [polypeptide binding]; other site 945711003107 KMSKS motif; other site 945711003108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711003109 RNA binding surface [nucleotide binding]; other site 945711003110 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 945711003111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711003112 active site 945711003113 motif I; other site 945711003114 motif II; other site 945711003115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711003116 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 945711003117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711003118 RNA binding surface [nucleotide binding]; other site 945711003119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711003120 S-adenosylmethionine binding site [chemical binding]; other site 945711003121 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 945711003122 ATP-NAD kinase; Region: NAD_kinase; pfam01513 945711003123 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 945711003124 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 945711003125 Walker A/P-loop; other site 945711003126 ATP binding site [chemical binding]; other site 945711003127 Q-loop/lid; other site 945711003128 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 945711003129 ABC transporter signature motif; other site 945711003130 Walker B; other site 945711003131 D-loop; other site 945711003132 H-loop/switch region; other site 945711003133 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 945711003134 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 945711003135 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 945711003136 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 945711003137 dimer interface [polypeptide binding]; other site 945711003138 ADP-ribose binding site [chemical binding]; other site 945711003139 active site 945711003140 nudix motif; other site 945711003141 metal binding site [ion binding]; metal-binding site 945711003142 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 945711003143 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 945711003144 active site 945711003145 Int/Topo IB signature motif; other site 945711003146 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 945711003147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 945711003148 P-loop; other site 945711003149 Magnesium ion binding site [ion binding]; other site 945711003150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 945711003151 Magnesium ion binding site [ion binding]; other site 945711003152 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 945711003153 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 945711003154 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 945711003155 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 945711003156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711003157 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 945711003158 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945711003159 inhibitor-cofactor binding pocket; inhibition site 945711003160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711003161 catalytic residue [active] 945711003162 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 945711003163 AAA domain; Region: AAA_26; pfam13500 945711003164 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 945711003165 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 945711003166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711003167 RNA binding surface [nucleotide binding]; other site 945711003168 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 945711003169 active site 945711003170 cytidylate kinase; Provisional; Region: cmk; PRK00023 945711003171 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 945711003172 CMP-binding site; other site 945711003173 The sites determining sugar specificity; other site 945711003174 GTP-binding protein Der; Reviewed; Region: PRK03003 945711003175 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 945711003176 G1 box; other site 945711003177 GTP/Mg2+ binding site [chemical binding]; other site 945711003178 Switch I region; other site 945711003179 G2 box; other site 945711003180 Switch II region; other site 945711003181 G3 box; other site 945711003182 G4 box; other site 945711003183 G5 box; other site 945711003184 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 945711003185 G1 box; other site 945711003186 GTP/Mg2+ binding site [chemical binding]; other site 945711003187 Switch I region; other site 945711003188 G2 box; other site 945711003189 G3 box; other site 945711003190 Switch II region; other site 945711003191 G4 box; other site 945711003192 G5 box; other site 945711003193 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 945711003194 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 945711003195 hypothetical protein; Provisional; Region: PRK08317 945711003196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711003197 S-adenosylmethionine binding site [chemical binding]; other site 945711003198 Predicted esterase [General function prediction only]; Region: COG0627 945711003199 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 945711003200 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 945711003201 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711003202 intersubunit interface [polypeptide binding]; other site 945711003203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711003204 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711003205 dimer interface [polypeptide binding]; other site 945711003206 putative PBP binding regions; other site 945711003207 ABC-ATPase subunit interface; other site 945711003208 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 945711003209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711003210 ABC-ATPase subunit interface; other site 945711003211 dimer interface [polypeptide binding]; other site 945711003212 putative PBP binding regions; other site 945711003213 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711003214 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711003215 Walker A/P-loop; other site 945711003216 ATP binding site [chemical binding]; other site 945711003217 Q-loop/lid; other site 945711003218 ABC transporter signature motif; other site 945711003219 Walker B; other site 945711003220 D-loop; other site 945711003221 H-loop/switch region; other site 945711003222 IucA / IucC family; Region: IucA_IucC; pfam04183 945711003223 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 945711003224 IucA / IucC family; Region: IucA_IucC; pfam04183 945711003225 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 945711003226 H+ Antiporter protein; Region: 2A0121; TIGR00900 945711003227 hypothetical protein; Provisional; Region: PRK01842 945711003228 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 945711003229 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 945711003230 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 945711003231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 945711003232 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 945711003233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711003234 nucleotide binding region [chemical binding]; other site 945711003235 ATP-binding site [chemical binding]; other site 945711003236 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 945711003237 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 945711003238 phosphopeptide binding site; other site 945711003239 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 945711003240 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945711003241 DNA binding residues [nucleotide binding] 945711003242 Bifunctional nuclease; Region: DNase-RNase; pfam02577 945711003243 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 945711003244 DNA binding residues [nucleotide binding] 945711003245 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945711003246 putative dimer interface [polypeptide binding]; other site 945711003247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 945711003248 metal ion-dependent adhesion site (MIDAS); other site 945711003249 Domain of unknown function DUF21; Region: DUF21; pfam01595 945711003250 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 945711003251 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 945711003252 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 945711003253 Domain of unknown function DUF21; Region: DUF21; pfam01595 945711003254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 945711003255 Transporter associated domain; Region: CorC_HlyC; smart01091 945711003256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 945711003257 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945711003258 ATP binding site [chemical binding]; other site 945711003259 putative Mg++ binding site [ion binding]; other site 945711003260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711003261 nucleotide binding region [chemical binding]; other site 945711003262 ATP-binding site [chemical binding]; other site 945711003263 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 945711003264 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 945711003265 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 945711003266 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 945711003267 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 945711003268 CoenzymeA binding site [chemical binding]; other site 945711003269 subunit interaction site [polypeptide binding]; other site 945711003270 PHB binding site; other site 945711003271 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 945711003272 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 945711003273 oligomer interface [polypeptide binding]; other site 945711003274 metal binding site [ion binding]; metal-binding site 945711003275 metal binding site [ion binding]; metal-binding site 945711003276 putative Cl binding site [ion binding]; other site 945711003277 basic sphincter; other site 945711003278 hydrophobic gate; other site 945711003279 periplasmic entrance; other site 945711003280 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945711003281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711003282 S-adenosylmethionine binding site [chemical binding]; other site 945711003283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711003284 Walker A/P-loop; other site 945711003285 ATP binding site [chemical binding]; other site 945711003286 ABC transporter; Region: ABC_tran; pfam00005 945711003287 ABC transporter signature motif; other site 945711003288 Walker B; other site 945711003289 D-loop; other site 945711003290 H-loop/switch region; other site 945711003291 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 945711003292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945711003293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945711003294 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 945711003295 metabolite-proton symporter; Region: 2A0106; TIGR00883 945711003296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711003297 putative substrate translocation pore; other site 945711003298 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 945711003299 FAD binding domain; Region: FAD_binding_4; pfam01565 945711003300 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945711003301 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 945711003302 Cysteine-rich domain; Region: CCG; pfam02754 945711003303 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 945711003304 Sodium Bile acid symporter family; Region: SBF; pfam01758 945711003305 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 945711003306 YceI-like domain; Region: YceI; pfam04264 945711003307 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 945711003308 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 945711003309 Ligand binding site; other site 945711003310 Putative Catalytic site; other site 945711003311 DXD motif; other site 945711003312 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 945711003313 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 945711003314 putative active site [active] 945711003315 catalytic triad [active] 945711003316 putative dimer interface [polypeptide binding]; other site 945711003317 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 945711003318 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 945711003319 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 945711003320 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 945711003321 precorrin-3B synthase; Region: CobG; TIGR02435 945711003322 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 945711003323 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 945711003324 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 945711003325 Precorrin-8X methylmutase; Region: CbiC; pfam02570 945711003326 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 945711003327 active site 945711003328 SAM binding site [chemical binding]; other site 945711003329 homodimer interface [polypeptide binding]; other site 945711003330 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 945711003331 homodimer interface [polypeptide binding]; other site 945711003332 active site 945711003333 SAM binding site [chemical binding]; other site 945711003334 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 945711003335 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 945711003336 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 945711003337 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 945711003338 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 945711003339 active site 945711003340 SAM binding site [chemical binding]; other site 945711003341 homodimer interface [polypeptide binding]; other site 945711003342 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 945711003343 active site 945711003344 putative homodimer interface [polypeptide binding]; other site 945711003345 SAM binding site [chemical binding]; other site 945711003346 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 945711003347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945711003348 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 945711003349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711003350 NAD(P) binding site [chemical binding]; other site 945711003351 active site 945711003352 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 945711003353 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 945711003354 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 945711003355 active site 945711003356 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945711003357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711003358 ATP binding site [chemical binding]; other site 945711003359 putative Mg++ binding site [ion binding]; other site 945711003360 helicase superfamily c-terminal domain; Region: HELICc; smart00490 945711003361 nucleotide binding region [chemical binding]; other site 945711003362 ATP-binding site [chemical binding]; other site 945711003363 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 945711003364 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 945711003365 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 945711003366 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 945711003367 Predicted transcriptional regulator [Transcription]; Region: COG2378 945711003368 WYL domain; Region: WYL; pfam13280 945711003369 WYL domain; Region: WYL; pfam13280 945711003370 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 945711003371 Pup-like protein; Region: Pup; pfam05639 945711003372 Pup-ligase protein; Region: Pup_ligase; cl15463 945711003373 proteasome ATPase; Region: pup_AAA; TIGR03689 945711003374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711003375 Walker A motif; other site 945711003376 ATP binding site [chemical binding]; other site 945711003377 Walker B motif; other site 945711003378 arginine finger; other site 945711003379 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 945711003380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945711003381 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 945711003382 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 945711003383 active site 945711003384 metal binding site [ion binding]; metal-binding site 945711003385 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 945711003386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 945711003387 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 945711003388 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 945711003389 Potassium binding sites [ion binding]; other site 945711003390 Cesium cation binding sites [ion binding]; other site 945711003391 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 945711003392 Aspartase; Region: Aspartase; cd01357 945711003393 active sites [active] 945711003394 tetramer interface [polypeptide binding]; other site 945711003395 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 945711003396 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 945711003397 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 945711003398 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 945711003399 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 945711003400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 945711003401 homodimer interface [polypeptide binding]; other site 945711003402 putative metal binding site [ion binding]; other site 945711003403 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 945711003404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711003405 motif II; other site 945711003406 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 945711003407 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 945711003408 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 945711003409 substrate binding pocket [chemical binding]; other site 945711003410 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 945711003411 B12 binding site [chemical binding]; other site 945711003412 cobalt ligand [ion binding]; other site 945711003413 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 945711003414 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 945711003415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711003416 active site 945711003417 HIGH motif; other site 945711003418 nucleotide binding site [chemical binding]; other site 945711003419 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711003420 active site 945711003421 KMSKS motif; other site 945711003422 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 945711003423 tRNA binding surface [nucleotide binding]; other site 945711003424 anticodon binding site; other site 945711003425 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 945711003426 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945711003427 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945711003428 active site 945711003429 catalytic tetrad [active] 945711003430 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 945711003431 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 945711003432 quinone interaction residues [chemical binding]; other site 945711003433 active site 945711003434 catalytic residues [active] 945711003435 FMN binding site [chemical binding]; other site 945711003436 substrate binding site [chemical binding]; other site 945711003437 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 945711003438 substrate binding site [chemical binding]; other site 945711003439 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 945711003440 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 945711003441 dimerization domain swap beta strand [polypeptide binding]; other site 945711003442 regulatory protein interface [polypeptide binding]; other site 945711003443 active site 945711003444 regulatory phosphorylation site [posttranslational modification]; other site 945711003445 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 945711003446 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 945711003447 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 945711003448 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 945711003449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711003450 Walker A/P-loop; other site 945711003451 ATP binding site [chemical binding]; other site 945711003452 Q-loop/lid; other site 945711003453 ABC transporter signature motif; other site 945711003454 Walker B; other site 945711003455 D-loop; other site 945711003456 H-loop/switch region; other site 945711003457 ABC transporter; Region: ABC_tran_2; pfam12848 945711003458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711003459 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 945711003460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711003461 NAD(P) binding site [chemical binding]; other site 945711003462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711003463 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 945711003464 NAD(P) binding site [chemical binding]; other site 945711003465 active site 945711003466 membrane ATPase/protein kinase; Provisional; Region: PRK09435 945711003467 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 945711003468 Walker A; other site 945711003469 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 945711003470 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 945711003471 active site 945711003472 substrate binding site [chemical binding]; other site 945711003473 coenzyme B12 binding site [chemical binding]; other site 945711003474 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 945711003475 B12 binding site [chemical binding]; other site 945711003476 cobalt ligand [ion binding]; other site 945711003477 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 945711003478 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 945711003479 heterodimer interface [polypeptide binding]; other site 945711003480 substrate interaction site [chemical binding]; other site 945711003481 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945711003482 Uncharacterized conserved protein [Function unknown]; Region: COG0398 945711003483 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 945711003484 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 945711003485 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 945711003486 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 945711003487 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 945711003488 ferrochelatase; Reviewed; Region: hemH; PRK00035 945711003489 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 945711003490 C-terminal domain interface [polypeptide binding]; other site 945711003491 active site 945711003492 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 945711003493 active site 945711003494 N-terminal domain interface [polypeptide binding]; other site 945711003495 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945711003496 NlpC/P60 family; Region: NLPC_P60; pfam00877 945711003497 aconitate hydratase; Validated; Region: PRK09277 945711003498 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 945711003499 substrate binding site [chemical binding]; other site 945711003500 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 945711003501 ligand binding site [chemical binding]; other site 945711003502 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 945711003503 substrate binding site [chemical binding]; other site 945711003504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711003505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711003506 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 945711003507 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 945711003508 catalytic triad [active] 945711003509 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 945711003510 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 945711003511 AAA ATPase domain; Region: AAA_16; pfam13191 945711003512 AAA domain; Region: AAA_22; pfam13401 945711003513 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 945711003514 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 945711003515 amidase catalytic site [active] 945711003516 Zn binding residues [ion binding]; other site 945711003517 substrate binding site [chemical binding]; other site 945711003518 Phage-related minor tail protein [Function unknown]; Region: COG5280 945711003519 Phage-related protein [Function unknown]; Region: COG5412 945711003520 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 945711003521 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 945711003522 Clp protease; Region: CLP_protease; pfam00574 945711003523 oligomer interface [polypeptide binding]; other site 945711003524 active site residues [active] 945711003525 large terminase protein; Provisional; Region: 17; PHA02533 945711003526 Phage terminase, small subunit; Region: Terminase_4; cl01525 945711003527 AAA domain; Region: AAA_14; pfam13173 945711003528 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945711003529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711003530 ATP binding site [chemical binding]; other site 945711003531 putative Mg++ binding site [ion binding]; other site 945711003532 VRR-NUC domain; Region: VRR_NUC; pfam08774 945711003533 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 945711003534 Virulence-associated protein E; Region: VirE; pfam05272 945711003535 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 945711003536 active site 945711003537 DNA binding site [nucleotide binding] 945711003538 catalytic site [active] 945711003539 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 945711003540 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 945711003541 AntA/AntB antirepressor; Region: AntA; cl01430 945711003542 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 945711003543 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 945711003544 Domain of unknown function (DUF955); Region: DUF955; pfam06114 945711003545 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 945711003546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 945711003547 active site 945711003548 DNA binding site [nucleotide binding] 945711003549 Int/Topo IB signature motif; other site 945711003550 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 945711003551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711003552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711003553 Walker A/P-loop; other site 945711003554 ATP binding site [chemical binding]; other site 945711003555 Q-loop/lid; other site 945711003556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711003557 ABC transporter signature motif; other site 945711003558 Walker B; other site 945711003559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711003560 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 945711003561 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 945711003562 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 945711003563 trimerization site [polypeptide binding]; other site 945711003564 active site 945711003565 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 945711003566 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 945711003567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945711003568 catalytic residue [active] 945711003569 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 945711003570 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 945711003571 Walker A/P-loop; other site 945711003572 ATP binding site [chemical binding]; other site 945711003573 Q-loop/lid; other site 945711003574 ABC transporter signature motif; other site 945711003575 Walker B; other site 945711003576 D-loop; other site 945711003577 H-loop/switch region; other site 945711003578 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 945711003579 FeS assembly protein SufD; Region: sufD; TIGR01981 945711003580 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 945711003581 FeS assembly protein SufB; Region: sufB; TIGR01980 945711003582 Predicted transcriptional regulator [Transcription]; Region: COG2345 945711003583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945711003584 putative DNA binding site [nucleotide binding]; other site 945711003585 putative Zn2+ binding site [ion binding]; other site 945711003586 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 945711003587 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711003588 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945711003589 Walker A/P-loop; other site 945711003590 ATP binding site [chemical binding]; other site 945711003591 Q-loop/lid; other site 945711003592 ABC transporter signature motif; other site 945711003593 Walker B; other site 945711003594 D-loop; other site 945711003595 H-loop/switch region; other site 945711003596 ABC-2 type transporter; Region: ABC2_membrane; cl17235 945711003597 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 945711003598 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 945711003599 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 945711003600 UbiA prenyltransferase family; Region: UbiA; pfam01040 945711003601 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 945711003602 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 945711003603 TPP-binding site [chemical binding]; other site 945711003604 dimer interface [polypeptide binding]; other site 945711003605 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 945711003606 PYR/PP interface [polypeptide binding]; other site 945711003607 dimer interface [polypeptide binding]; other site 945711003608 TPP binding site [chemical binding]; other site 945711003609 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945711003610 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 945711003611 putative active site [active] 945711003612 transaldolase; Provisional; Region: PRK03903 945711003613 catalytic residue [active] 945711003614 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 945711003615 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 945711003616 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 945711003617 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 945711003618 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 945711003619 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 945711003620 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 945711003621 putative active site [active] 945711003622 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 945711003623 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 945711003624 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 945711003625 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 945711003626 triosephosphate isomerase; Provisional; Region: PRK14567 945711003627 substrate binding site [chemical binding]; other site 945711003628 dimer interface [polypeptide binding]; other site 945711003629 catalytic triad [active] 945711003630 Phosphoglycerate kinase; Region: PGK; pfam00162 945711003631 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 945711003632 substrate binding site [chemical binding]; other site 945711003633 hinge regions; other site 945711003634 ADP binding site [chemical binding]; other site 945711003635 catalytic site [active] 945711003636 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 945711003637 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 945711003638 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 945711003639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 945711003640 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 945711003641 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 945711003642 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 945711003643 phosphate binding site [ion binding]; other site 945711003644 putative substrate binding pocket [chemical binding]; other site 945711003645 dimer interface [polypeptide binding]; other site 945711003646 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 945711003647 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 945711003648 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 945711003649 GIY-YIG motif/motif A; other site 945711003650 active site 945711003651 catalytic site [active] 945711003652 putative DNA binding site [nucleotide binding]; other site 945711003653 metal binding site [ion binding]; metal-binding site 945711003654 UvrB/uvrC motif; Region: UVR; pfam02151 945711003655 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 945711003656 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 945711003657 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 945711003658 homopentamer interface [polypeptide binding]; other site 945711003659 active site 945711003660 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 945711003661 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 945711003662 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 945711003663 dimerization interface [polypeptide binding]; other site 945711003664 active site 945711003665 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 945711003666 Lumazine binding domain; Region: Lum_binding; pfam00677 945711003667 Lumazine binding domain; Region: Lum_binding; pfam00677 945711003668 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 945711003669 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 945711003670 catalytic motif [active] 945711003671 Zn binding site [ion binding]; other site 945711003672 RibD C-terminal domain; Region: RibD_C; pfam01872 945711003673 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 945711003674 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 945711003675 substrate binding site [chemical binding]; other site 945711003676 hexamer interface [polypeptide binding]; other site 945711003677 metal binding site [ion binding]; metal-binding site 945711003678 16S rRNA methyltransferase B; Provisional; Region: PRK14902 945711003679 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 945711003680 putative RNA binding site [nucleotide binding]; other site 945711003681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711003682 S-adenosylmethionine binding site [chemical binding]; other site 945711003683 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 945711003684 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 945711003685 putative active site [active] 945711003686 substrate binding site [chemical binding]; other site 945711003687 putative cosubstrate binding site; other site 945711003688 catalytic site [active] 945711003689 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 945711003690 substrate binding site [chemical binding]; other site 945711003691 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 945711003692 active site 945711003693 catalytic residues [active] 945711003694 metal binding site [ion binding]; metal-binding site 945711003695 primosome assembly protein PriA; Provisional; Region: PRK14873 945711003696 S-adenosylmethionine synthetase; Validated; Region: PRK05250 945711003697 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 945711003698 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 945711003699 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 945711003700 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 945711003701 Flavoprotein; Region: Flavoprotein; pfam02441 945711003702 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 945711003703 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 945711003704 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 945711003705 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 945711003706 catalytic site [active] 945711003707 G-X2-G-X-G-K; other site 945711003708 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 945711003709 active site 945711003710 dimer interface [polypeptide binding]; other site 945711003711 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 945711003712 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945711003713 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945711003714 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 945711003715 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945711003716 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945711003717 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 945711003718 IMP binding site; other site 945711003719 dimer interface [polypeptide binding]; other site 945711003720 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 945711003721 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 945711003722 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 945711003723 catalytic site [active] 945711003724 subunit interface [polypeptide binding]; other site 945711003725 dihydroorotase; Validated; Region: pyrC; PRK09357 945711003726 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 945711003727 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 945711003728 active site 945711003729 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 945711003730 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 945711003731 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 945711003732 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 945711003733 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711003734 active site 945711003735 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 945711003736 hydrophobic ligand binding site; other site 945711003737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711003738 TIGR01777 family protein; Region: yfcH 945711003739 NAD(P) binding site [chemical binding]; other site 945711003740 active site 945711003741 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 945711003742 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 945711003743 putative RNA binding site [nucleotide binding]; other site 945711003744 elongation factor P; Validated; Region: PRK00529 945711003745 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 945711003746 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 945711003747 RNA binding site [nucleotide binding]; other site 945711003748 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 945711003749 RNA binding site [nucleotide binding]; other site 945711003750 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 945711003751 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 945711003752 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 945711003753 active site 945711003754 Dehydroquinase class II; Region: DHquinase_II; pfam01220 945711003755 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 945711003756 trimer interface [polypeptide binding]; other site 945711003757 active site 945711003758 dimer interface [polypeptide binding]; other site 945711003759 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 945711003760 active site 945711003761 dimer interface [polypeptide binding]; other site 945711003762 metal binding site [ion binding]; metal-binding site 945711003763 shikimate kinase; Reviewed; Region: aroK; PRK00131 945711003764 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 945711003765 ADP binding site [chemical binding]; other site 945711003766 magnesium binding site [ion binding]; other site 945711003767 putative shikimate binding site; other site 945711003768 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 945711003769 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 945711003770 Tetramer interface [polypeptide binding]; other site 945711003771 active site 945711003772 FMN-binding site [chemical binding]; other site 945711003773 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 945711003774 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 945711003775 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 945711003776 shikimate binding site; other site 945711003777 NAD(P) binding site [chemical binding]; other site 945711003778 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 945711003779 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 945711003780 dimerization interface [polypeptide binding]; other site 945711003781 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 945711003782 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 945711003783 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 945711003784 motif 1; other site 945711003785 active site 945711003786 motif 2; other site 945711003787 motif 3; other site 945711003788 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 945711003789 DHHA1 domain; Region: DHHA1; pfam02272 945711003790 recombination factor protein RarA; Reviewed; Region: PRK13342 945711003791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711003792 Walker A motif; other site 945711003793 ATP binding site [chemical binding]; other site 945711003794 Walker B motif; other site 945711003795 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 945711003796 Phosphotransferase enzyme family; Region: APH; pfam01636 945711003797 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 945711003798 substrate binding site [chemical binding]; other site 945711003799 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 945711003800 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 945711003801 dimer interface [polypeptide binding]; other site 945711003802 anticodon binding site; other site 945711003803 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 945711003804 homodimer interface [polypeptide binding]; other site 945711003805 motif 1; other site 945711003806 active site 945711003807 motif 2; other site 945711003808 GAD domain; Region: GAD; pfam02938 945711003809 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945711003810 active site 945711003811 motif 3; other site 945711003812 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 945711003813 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945711003814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711003815 ATP binding site [chemical binding]; other site 945711003816 putative Mg++ binding site [ion binding]; other site 945711003817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711003818 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 945711003819 nucleotide binding region [chemical binding]; other site 945711003820 ATP-binding site [chemical binding]; other site 945711003821 Predicted membrane protein [Function unknown]; Region: COG1511 945711003822 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 945711003823 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 945711003824 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 945711003825 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 945711003826 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 945711003827 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 945711003828 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 945711003829 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 945711003830 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 945711003831 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 945711003832 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 945711003833 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 945711003834 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 945711003835 dimer interface [polypeptide binding]; other site 945711003836 motif 1; other site 945711003837 active site 945711003838 motif 2; other site 945711003839 motif 3; other site 945711003840 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 945711003841 anticodon binding site; other site 945711003842 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 945711003843 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 945711003844 dimer interface [polypeptide binding]; other site 945711003845 catalytic triad [active] 945711003846 peroxidatic and resolving cysteines [active] 945711003847 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 945711003848 active site 945711003849 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 945711003850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945711003851 Zn2+ binding site [ion binding]; other site 945711003852 Mg2+ binding site [ion binding]; other site 945711003853 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 945711003854 synthetase active site [active] 945711003855 NTP binding site [chemical binding]; other site 945711003856 metal binding site [ion binding]; metal-binding site 945711003857 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 945711003858 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 945711003859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711003860 active site 945711003861 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 945711003862 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 945711003863 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 945711003864 Protein export membrane protein; Region: SecD_SecF; pfam02355 945711003865 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 945711003866 Protein export membrane protein; Region: SecD_SecF; cl14618 945711003867 Preprotein translocase subunit; Region: YajC; pfam02699 945711003868 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 945711003869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711003870 Walker A motif; other site 945711003871 ATP binding site [chemical binding]; other site 945711003872 Walker B motif; other site 945711003873 arginine finger; other site 945711003874 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 945711003875 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 945711003876 RuvA N terminal domain; Region: RuvA_N; pfam01330 945711003877 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 945711003878 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 945711003879 active site 945711003880 putative DNA-binding cleft [nucleotide binding]; other site 945711003881 dimer interface [polypeptide binding]; other site 945711003882 hypothetical protein; Validated; Region: PRK00110 945711003883 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 945711003884 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 945711003885 active site 945711003886 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 945711003887 catalytic triad [active] 945711003888 dimer interface [polypeptide binding]; other site 945711003889 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 945711003890 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 945711003891 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 945711003892 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945711003893 catalytic residue [active] 945711003894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945711003895 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945711003896 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 945711003897 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 945711003898 putative acyl-acceptor binding pocket; other site 945711003899 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 945711003900 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 945711003901 nucleotide binding site/active site [active] 945711003902 HIT family signature motif; other site 945711003903 catalytic residue [active] 945711003904 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 945711003905 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 945711003906 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 945711003907 active site 945711003908 dimer interface [polypeptide binding]; other site 945711003909 motif 1; other site 945711003910 motif 2; other site 945711003911 motif 3; other site 945711003912 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 945711003913 anticodon binding site; other site 945711003914 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 945711003915 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 945711003916 Protein of unknown function (DUF461); Region: DUF461; pfam04314 945711003917 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 945711003918 hypothetical protein; Provisional; Region: PRK14059 945711003919 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 945711003920 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 945711003921 SelR domain; Region: SelR; pfam01641 945711003922 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 945711003923 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 945711003924 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 945711003925 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 945711003926 catalytic site [active] 945711003927 putative active site [active] 945711003928 putative substrate binding site [chemical binding]; other site 945711003929 HRDC domain; Region: HRDC; pfam00570 945711003930 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 945711003931 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 945711003932 TPP-binding site; other site 945711003933 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 945711003934 PYR/PP interface [polypeptide binding]; other site 945711003935 dimer interface [polypeptide binding]; other site 945711003936 TPP binding site [chemical binding]; other site 945711003937 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945711003938 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 945711003939 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 945711003940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945711003941 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 945711003942 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 945711003943 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 945711003944 trimer interface [polypeptide binding]; other site 945711003945 active site 945711003946 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 945711003947 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 945711003948 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945711003949 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 945711003950 active site 945711003951 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 945711003952 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945711003953 nucleotide binding site [chemical binding]; other site 945711003954 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 945711003955 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 945711003956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711003957 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 945711003958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711003959 DNA binding residues [nucleotide binding] 945711003960 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 945711003961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711003962 ATP binding site [chemical binding]; other site 945711003963 putative Mg++ binding site [ion binding]; other site 945711003964 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 945711003965 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 945711003966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711003967 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 945711003968 S-adenosylmethionine binding site [chemical binding]; other site 945711003969 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 945711003970 putative active site [active] 945711003971 dimerization interface [polypeptide binding]; other site 945711003972 putative tRNAtyr binding site [nucleotide binding]; other site 945711003973 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 945711003974 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 945711003975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711003976 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 945711003977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711003978 DNA binding residues [nucleotide binding] 945711003979 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 945711003980 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 945711003981 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 945711003982 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 945711003983 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 945711003984 NAD binding site [chemical binding]; other site 945711003985 homodimer interface [polypeptide binding]; other site 945711003986 active site 945711003987 substrate binding site [chemical binding]; other site 945711003988 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 945711003989 PAC2 family; Region: PAC2; pfam09754 945711003990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711003991 ATP binding site [chemical binding]; other site 945711003992 putative Mg++ binding site [ion binding]; other site 945711003993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711003994 nucleotide binding region [chemical binding]; other site 945711003995 ATP-binding site [chemical binding]; other site 945711003996 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 945711003997 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 945711003998 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 945711003999 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 945711004000 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 945711004001 dimer interface [polypeptide binding]; other site 945711004002 decamer (pentamer of dimers) interface [polypeptide binding]; other site 945711004003 catalytic triad [active] 945711004004 peroxidatic and resolving cysteines [active] 945711004005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 945711004006 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 945711004007 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 945711004008 dimerization interface [polypeptide binding]; other site 945711004009 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 945711004010 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 945711004011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945711004012 ATP binding site [chemical binding]; other site 945711004013 putative Mg++ binding site [ion binding]; other site 945711004014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945711004015 nucleotide binding region [chemical binding]; other site 945711004016 ATP-binding site [chemical binding]; other site 945711004017 Helicase associated domain (HA2); Region: HA2; pfam04408 945711004018 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 945711004019 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 945711004020 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 945711004021 ATP cone domain; Region: ATP-cone; pfam03477 945711004022 LexA repressor; Validated; Region: PRK00215 945711004023 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 945711004024 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 945711004025 Catalytic site [active] 945711004026 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 945711004027 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 945711004028 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 945711004029 potential frameshift: common BLAST hit: gi|337290948|ref|YP_004629969.1| phosphoenolpyruvate-protein phosphotransferase 945711004030 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 945711004031 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 945711004032 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 945711004033 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 945711004034 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 945711004035 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 945711004036 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 945711004037 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 945711004038 putative substrate binding site [chemical binding]; other site 945711004039 putative ATP binding site [chemical binding]; other site 945711004040 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 945711004041 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 945711004042 active site 945711004043 phosphorylation site [posttranslational modification] 945711004044 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 945711004045 active site 945711004046 P-loop; other site 945711004047 phosphorylation site [posttranslational modification] 945711004048 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 945711004049 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 945711004050 dimerization domain swap beta strand [polypeptide binding]; other site 945711004051 regulatory protein interface [polypeptide binding]; other site 945711004052 active site 945711004053 regulatory phosphorylation site [posttranslational modification]; other site 945711004054 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 945711004055 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 945711004056 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 945711004057 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 945711004058 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 945711004059 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 945711004060 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 945711004061 GTPases [General function prediction only]; Region: HflX; COG2262 945711004062 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 945711004063 HflX GTPase family; Region: HflX; cd01878 945711004064 G1 box; other site 945711004065 GTP/Mg2+ binding site [chemical binding]; other site 945711004066 Switch I region; other site 945711004067 G2 box; other site 945711004068 G3 box; other site 945711004069 Switch II region; other site 945711004070 G4 box; other site 945711004071 G5 box; other site 945711004072 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 945711004073 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 945711004074 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 945711004075 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 945711004076 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 945711004077 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 945711004078 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 945711004079 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 945711004080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 945711004081 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 945711004082 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 945711004083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711004084 FeS/SAM binding site; other site 945711004085 recombination regulator RecX; Reviewed; Region: recX; PRK00117 945711004086 recombinase A; Provisional; Region: recA; PRK09354 945711004087 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 945711004088 hexamer interface [polypeptide binding]; other site 945711004089 Walker A motif; other site 945711004090 ATP binding site [chemical binding]; other site 945711004091 Walker B motif; other site 945711004092 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 945711004093 BioY family; Region: BioY; pfam02632 945711004094 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 945711004095 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 945711004096 Walker A/P-loop; other site 945711004097 ATP binding site [chemical binding]; other site 945711004098 Q-loop/lid; other site 945711004099 ABC transporter signature motif; other site 945711004100 Walker B; other site 945711004101 D-loop; other site 945711004102 H-loop/switch region; other site 945711004103 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 945711004104 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 945711004105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 945711004106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 945711004107 sequence-specific DNA binding site [nucleotide binding]; other site 945711004108 salt bridge; other site 945711004109 Competence-damaged protein; Region: CinA; pfam02464 945711004110 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 945711004111 YCII-related domain; Region: YCII; cl00999 945711004112 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 945711004113 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 945711004114 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 945711004115 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 945711004116 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 945711004117 TIGR03085 family protein; Region: TIGR03085 945711004118 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 945711004119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 945711004120 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 945711004121 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 945711004122 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 945711004123 dimer interface [polypeptide binding]; other site 945711004124 active site 945711004125 catalytic residue [active] 945711004126 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 945711004127 dihydrodipicolinate reductase; Provisional; Region: PRK00048 945711004128 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 945711004129 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 945711004130 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 945711004131 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 945711004132 oligomer interface [polypeptide binding]; other site 945711004133 RNA binding site [nucleotide binding]; other site 945711004134 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 945711004135 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 945711004136 RNase E interface [polypeptide binding]; other site 945711004137 trimer interface [polypeptide binding]; other site 945711004138 active site 945711004139 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 945711004140 putative nucleic acid binding region [nucleotide binding]; other site 945711004141 G-X-X-G motif; other site 945711004142 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 945711004143 RNA binding site [nucleotide binding]; other site 945711004144 domain interface; other site 945711004145 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 945711004146 16S/18S rRNA binding site [nucleotide binding]; other site 945711004147 S13e-L30e interaction site [polypeptide binding]; other site 945711004148 25S rRNA binding site [nucleotide binding]; other site 945711004149 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 945711004150 active site 945711004151 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 945711004152 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 945711004153 active site 945711004154 Riboflavin kinase; Region: Flavokinase; smart00904 945711004155 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 945711004156 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 945711004157 RNA binding site [nucleotide binding]; other site 945711004158 active site 945711004159 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 945711004160 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 945711004161 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 945711004162 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945711004163 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 945711004164 active site 945711004165 metal binding site [ion binding]; metal-binding site 945711004166 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 945711004167 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 945711004168 DHH family; Region: DHH; pfam01368 945711004169 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 945711004170 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 945711004171 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 945711004172 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 945711004173 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 945711004174 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 945711004175 G1 box; other site 945711004176 putative GEF interaction site [polypeptide binding]; other site 945711004177 GTP/Mg2+ binding site [chemical binding]; other site 945711004178 Switch I region; other site 945711004179 G2 box; other site 945711004180 G3 box; other site 945711004181 Switch II region; other site 945711004182 G4 box; other site 945711004183 G5 box; other site 945711004184 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 945711004185 Translation-initiation factor 2; Region: IF-2; pfam11987 945711004186 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 945711004187 Protein of unknown function (DUF448); Region: DUF448; pfam04296 945711004188 putative RNA binding cleft [nucleotide binding]; other site 945711004189 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 945711004190 NusA N-terminal domain; Region: NusA_N; pfam08529 945711004191 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 945711004192 RNA binding site [nucleotide binding]; other site 945711004193 homodimer interface [polypeptide binding]; other site 945711004194 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 945711004195 G-X-X-G motif; other site 945711004196 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 945711004197 G-X-X-G motif; other site 945711004198 ribosome maturation protein RimP; Reviewed; Region: PRK00092 945711004199 Sm and related proteins; Region: Sm_like; cl00259 945711004200 heptamer interface [polypeptide binding]; other site 945711004201 Sm1 motif; other site 945711004202 hexamer interface [polypeptide binding]; other site 945711004203 RNA binding site [nucleotide binding]; other site 945711004204 Sm2 motif; other site 945711004205 prolyl-tRNA synthetase; Provisional; Region: PRK09194 945711004206 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 945711004207 dimer interface [polypeptide binding]; other site 945711004208 motif 1; other site 945711004209 active site 945711004210 motif 2; other site 945711004211 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 945711004212 putative deacylase active site [active] 945711004213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945711004214 active site 945711004215 motif 3; other site 945711004216 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 945711004217 anticodon binding site; other site 945711004218 hypothetical protein; Validated; Region: PRK02101 945711004219 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 945711004220 active site 945711004221 SAM binding site [chemical binding]; other site 945711004222 homodimer interface [polypeptide binding]; other site 945711004223 Uncharacterized conserved protein [Function unknown]; Region: COG0397 945711004224 hypothetical protein; Validated; Region: PRK00029 945711004225 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 945711004226 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 945711004227 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 945711004228 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 945711004229 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 945711004230 DNA binding site [nucleotide binding] 945711004231 active site 945711004232 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 945711004233 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 945711004234 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 945711004235 catalytic triad [active] 945711004236 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 945711004237 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 945711004238 Walker A motif; other site 945711004239 homodimer interface [polypeptide binding]; other site 945711004240 ATP binding site [chemical binding]; other site 945711004241 hydroxycobalamin binding site [chemical binding]; other site 945711004242 Walker B motif; other site 945711004243 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 945711004244 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 945711004245 metal ion-dependent adhesion site (MIDAS); other site 945711004246 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 945711004247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711004248 Walker A motif; other site 945711004249 ATP binding site [chemical binding]; other site 945711004250 Walker B motif; other site 945711004251 arginine finger; other site 945711004252 malate:quinone oxidoreductase; Validated; Region: PRK05257 945711004253 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 945711004254 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 945711004255 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 945711004256 mycothione reductase; Reviewed; Region: PRK07846 945711004257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945711004258 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 945711004259 cobyric acid synthase; Provisional; Region: PRK00784 945711004260 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 945711004261 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 945711004262 catalytic triad [active] 945711004263 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 945711004264 active site 945711004265 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 945711004266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 945711004267 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 945711004268 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 945711004269 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 945711004270 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 945711004271 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 945711004272 active site 945711004273 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 945711004274 protein binding site [polypeptide binding]; other site 945711004275 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 945711004276 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 945711004277 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 945711004278 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 945711004279 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 945711004280 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 945711004281 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 945711004282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711004283 FeS/SAM binding site; other site 945711004284 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 945711004285 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 945711004286 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 945711004287 ribosome recycling factor; Reviewed; Region: frr; PRK00083 945711004288 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 945711004289 hinge region; other site 945711004290 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 945711004291 putative nucleotide binding site [chemical binding]; other site 945711004292 uridine monophosphate binding site [chemical binding]; other site 945711004293 homohexameric interface [polypeptide binding]; other site 945711004294 elongation factor Ts; Provisional; Region: tsf; PRK09377 945711004295 UBA/TS-N domain; Region: UBA; pfam00627 945711004296 Elongation factor TS; Region: EF_TS; pfam00889 945711004297 Elongation factor TS; Region: EF_TS; pfam00889 945711004298 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 945711004299 rRNA interaction site [nucleotide binding]; other site 945711004300 S8 interaction site; other site 945711004301 putative laminin-1 binding site; other site 945711004302 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 945711004303 Peptidase family M23; Region: Peptidase_M23; pfam01551 945711004304 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 945711004305 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 945711004306 active site 945711004307 DNA binding site [nucleotide binding] 945711004308 Int/Topo IB signature motif; other site 945711004309 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 945711004310 DNA protecting protein DprA; Region: dprA; TIGR00732 945711004311 potential frameshift: common BLAST hit: gi|383314495|ref|YP_005375350.1| ATP-dependent protease 945711004312 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 945711004313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 945711004314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711004315 Walker A motif; other site 945711004316 ATP binding site [chemical binding]; other site 945711004317 Walker B motif; other site 945711004318 arginine finger; other site 945711004319 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 945711004320 hypothetical protein; Reviewed; Region: PRK12497 945711004321 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 945711004322 ThiC-associated domain; Region: ThiC-associated; pfam13667 945711004323 ThiC family; Region: ThiC; pfam01964 945711004324 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 945711004325 thiamine phosphate binding site [chemical binding]; other site 945711004326 active site 945711004327 pyrophosphate binding site [ion binding]; other site 945711004328 hydroxyglutarate oxidase; Provisional; Region: PRK11728 945711004329 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 945711004330 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 945711004331 thiS-thiF/thiG interaction site; other site 945711004332 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 945711004333 ThiS interaction site; other site 945711004334 putative active site [active] 945711004335 tetramer interface [polypeptide binding]; other site 945711004336 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 945711004337 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 945711004338 ATP binding site [chemical binding]; other site 945711004339 substrate interface [chemical binding]; other site 945711004340 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 945711004341 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 945711004342 dimer interface [polypeptide binding]; other site 945711004343 substrate binding site [chemical binding]; other site 945711004344 ATP binding site [chemical binding]; other site 945711004345 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 945711004346 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 945711004347 RNA/DNA hybrid binding site [nucleotide binding]; other site 945711004348 active site 945711004349 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 945711004350 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 945711004351 Catalytic site [active] 945711004352 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 945711004353 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 945711004354 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 945711004355 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 945711004356 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 945711004357 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945711004358 RNA binding site [nucleotide binding]; other site 945711004359 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 945711004360 active site 945711004361 P-loop; other site 945711004362 phosphorylation site [posttranslational modification] 945711004363 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 945711004364 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 945711004365 active site 945711004366 phosphorylation site [posttranslational modification] 945711004367 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 945711004368 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 945711004369 RimM N-terminal domain; Region: RimM; pfam01782 945711004370 PRC-barrel domain; Region: PRC; pfam05239 945711004371 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 945711004372 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 945711004373 signal recognition particle protein; Provisional; Region: PRK10867 945711004374 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 945711004375 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 945711004376 P loop; other site 945711004377 GTP binding site [chemical binding]; other site 945711004378 Signal peptide binding domain; Region: SRP_SPB; pfam02978 945711004379 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 945711004380 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945711004381 metal binding triad; other site 945711004382 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 945711004383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945711004384 Zn2+ binding site [ion binding]; other site 945711004385 Mg2+ binding site [ion binding]; other site 945711004386 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 945711004387 Nitrogen regulatory protein P-II; Region: P-II; smart00938 945711004388 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 945711004389 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 945711004390 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 945711004391 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 945711004392 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 945711004393 Walker A/P-loop; other site 945711004394 ATP binding site [chemical binding]; other site 945711004395 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 945711004396 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 945711004397 ABC transporter signature motif; other site 945711004398 Walker B; other site 945711004399 D-loop; other site 945711004400 H-loop/switch region; other site 945711004401 Acylphosphatase; Region: Acylphosphatase; cl00551 945711004402 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 945711004403 amino acid carrier protein; Region: agcS; TIGR00835 945711004404 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 945711004405 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 945711004406 DNA binding site [nucleotide binding] 945711004407 catalytic residue [active] 945711004408 H2TH interface [polypeptide binding]; other site 945711004409 putative catalytic residues [active] 945711004410 turnover-facilitating residue; other site 945711004411 intercalation triad [nucleotide binding]; other site 945711004412 8OG recognition residue [nucleotide binding]; other site 945711004413 putative reading head residues; other site 945711004414 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 945711004415 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 945711004416 ribonuclease III; Reviewed; Region: rnc; PRK00102 945711004417 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 945711004418 dimerization interface [polypeptide binding]; other site 945711004419 active site 945711004420 metal binding site [ion binding]; metal-binding site 945711004421 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 945711004422 dsRNA binding site [nucleotide binding]; other site 945711004423 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 945711004424 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 945711004425 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 945711004426 RibD C-terminal domain; Region: RibD_C; cl17279 945711004427 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 945711004428 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 945711004429 hexamer interface [polypeptide binding]; other site 945711004430 ligand binding site [chemical binding]; other site 945711004431 putative active site [active] 945711004432 NAD(P) binding site [chemical binding]; other site 945711004433 glutamate dehydrogenase; Provisional; Region: PRK09414 945711004434 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 945711004435 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 945711004436 NAD(P) binding site [chemical binding]; other site 945711004437 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 945711004438 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 945711004439 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 945711004440 nucleotide binding site/active site [active] 945711004441 HIT family signature motif; other site 945711004442 catalytic residue [active] 945711004443 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 945711004444 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 945711004445 metal binding site [ion binding]; metal-binding site 945711004446 putative dimer interface [polypeptide binding]; other site 945711004447 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 945711004448 homodimer interface [polypeptide binding]; other site 945711004449 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 945711004450 active site pocket [active] 945711004451 Electron transfer DM13; Region: DM13; pfam10517 945711004452 pyruvate kinase; Provisional; Region: PRK06247 945711004453 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 945711004454 domain interfaces; other site 945711004455 active site 945711004456 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 945711004457 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 945711004458 active site 945711004459 ribulose/triose binding site [chemical binding]; other site 945711004460 phosphate binding site [ion binding]; other site 945711004461 substrate (anthranilate) binding pocket [chemical binding]; other site 945711004462 product (indole) binding pocket [chemical binding]; other site 945711004463 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 945711004464 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 945711004465 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 945711004466 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 945711004467 substrate binding site [chemical binding]; other site 945711004468 glutamase interaction surface [polypeptide binding]; other site 945711004469 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 945711004470 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945711004471 active site 945711004472 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 945711004473 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 945711004474 catalytic residues [active] 945711004475 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 945711004476 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 945711004477 putative active site [active] 945711004478 oxyanion strand; other site 945711004479 catalytic triad [active] 945711004480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945711004481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711004482 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 945711004483 putative active site pocket [active] 945711004484 4-fold oligomerization interface [polypeptide binding]; other site 945711004485 metal binding residues [ion binding]; metal-binding site 945711004486 3-fold/trimer interface [polypeptide binding]; other site 945711004487 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 945711004488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711004489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711004490 homodimer interface [polypeptide binding]; other site 945711004491 catalytic residue [active] 945711004492 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 945711004493 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 945711004494 NAD binding site [chemical binding]; other site 945711004495 dimerization interface [polypeptide binding]; other site 945711004496 product binding site; other site 945711004497 substrate binding site [chemical binding]; other site 945711004498 zinc binding site [ion binding]; other site 945711004499 catalytic residues [active] 945711004500 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 945711004501 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 945711004502 tetracycline repressor protein TetR; Provisional; Region: PRK13756 945711004503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711004504 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 945711004505 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 945711004506 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 945711004507 active site 945711004508 catalytic site [active] 945711004509 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 945711004510 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 945711004511 active site 945711004512 catalytic site [active] 945711004513 substrate binding site [chemical binding]; other site 945711004514 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 945711004515 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 945711004516 synthetase active site [active] 945711004517 NTP binding site [chemical binding]; other site 945711004518 metal binding site [ion binding]; metal-binding site 945711004519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711004520 RNA binding surface [nucleotide binding]; other site 945711004521 Uncharacterized conserved protein [Function unknown]; Region: COG1739 945711004522 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 945711004523 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 945711004524 threonine dehydratase; Validated; Region: PRK08639 945711004525 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 945711004526 tetramer interface [polypeptide binding]; other site 945711004527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711004528 catalytic residue [active] 945711004529 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 945711004530 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 945711004531 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 945711004532 active site 945711004533 PHP Thumb interface [polypeptide binding]; other site 945711004534 metal binding site [ion binding]; metal-binding site 945711004535 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 945711004536 generic binding surface I; other site 945711004537 generic binding surface II; other site 945711004538 Predicted permeases [General function prediction only]; Region: RarD; COG2962 945711004539 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 945711004540 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945711004541 RNA binding surface [nucleotide binding]; other site 945711004542 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 945711004543 active site 945711004544 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 945711004545 lipoprotein signal peptidase; Provisional; Region: PRK14787 945711004546 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 945711004547 active site 945711004548 homotetramer interface [polypeptide binding]; other site 945711004549 homodimer interface [polypeptide binding]; other site 945711004550 DNA polymerase IV; Provisional; Region: PRK03348 945711004551 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 945711004552 active site 945711004553 DNA binding site [nucleotide binding] 945711004554 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 945711004555 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 945711004556 HIGH motif; other site 945711004557 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 945711004558 active site 945711004559 KMSKS motif; other site 945711004560 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 945711004561 tRNA binding surface [nucleotide binding]; other site 945711004562 anticodon binding site; other site 945711004563 DivIVA domain; Region: DivI1A_domain; TIGR03544 945711004564 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 945711004565 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 945711004566 YGGT family; Region: YGGT; cl00508 945711004567 Protein of unknown function (DUF552); Region: DUF552; cl00775 945711004568 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 945711004569 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 945711004570 cell division protein FtsZ; Validated; Region: PRK09330 945711004571 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 945711004572 nucleotide binding site [chemical binding]; other site 945711004573 SulA interaction site; other site 945711004574 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 945711004575 Cell division protein FtsQ; Region: FtsQ; pfam03799 945711004576 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 945711004577 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 945711004578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945711004579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945711004580 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 945711004581 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 945711004582 homodimer interface [polypeptide binding]; other site 945711004583 active site 945711004584 cell division protein FtsW; Region: ftsW; TIGR02614 945711004585 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 945711004586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945711004587 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 945711004588 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 945711004589 Mg++ binding site [ion binding]; other site 945711004590 putative catalytic motif [active] 945711004591 putative substrate binding site [chemical binding]; other site 945711004592 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 945711004593 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 945711004594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945711004595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945711004596 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 945711004597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945711004598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945711004599 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 945711004600 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 945711004601 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 945711004602 Septum formation initiator; Region: DivIC; cl17659 945711004603 MraW methylase family; Region: Methyltransf_5; cl17771 945711004604 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 945711004605 cell division protein MraZ; Reviewed; Region: PRK00326 945711004606 MraZ protein; Region: MraZ; pfam02381 945711004607 MraZ protein; Region: MraZ; pfam02381 945711004608 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 945711004609 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 945711004610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 945711004611 Coenzyme A binding pocket [chemical binding]; other site 945711004612 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 945711004613 FAD binding site [chemical binding]; other site 945711004614 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 945711004615 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 945711004616 substrate binding pocket [chemical binding]; other site 945711004617 chain length determination region; other site 945711004618 substrate-Mg2+ binding site; other site 945711004619 catalytic residues [active] 945711004620 aspartate-rich region 1; other site 945711004621 active site lid residues [active] 945711004622 aspartate-rich region 2; other site 945711004623 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 945711004624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 945711004625 Catalytic domain of Protein Kinases; Region: PKc; cd00180 945711004626 active site 945711004627 ATP binding site [chemical binding]; other site 945711004628 substrate binding site [chemical binding]; other site 945711004629 activation loop (A-loop); other site 945711004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 945711004631 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711004632 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711004633 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711004634 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711004635 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945711004636 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 945711004637 Predicted membrane protein [Function unknown]; Region: COG4763 945711004638 Acyltransferase family; Region: Acyl_transf_3; pfam01757 945711004639 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 945711004640 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 945711004641 putative acyl-acceptor binding pocket; other site 945711004642 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 945711004643 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945711004644 nucleotide binding site [chemical binding]; other site 945711004645 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945711004646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945711004647 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 945711004648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945711004649 NlpC/P60 family; Region: NLPC_P60; pfam00877 945711004650 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945711004651 NlpC/P60 family; Region: NLPC_P60; pfam00877 945711004652 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 945711004653 heme bH binding site [chemical binding]; other site 945711004654 intrachain domain interface; other site 945711004655 heme bL binding site [chemical binding]; other site 945711004656 interchain domain interface [polypeptide binding]; other site 945711004657 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 945711004658 Qo binding site; other site 945711004659 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 945711004660 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 945711004661 iron-sulfur cluster [ion binding]; other site 945711004662 [2Fe-2S] cluster binding site [ion binding]; other site 945711004663 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 945711004664 Cytochrome c; Region: Cytochrom_C; pfam00034 945711004665 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 945711004666 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 945711004667 Subunit I/III interface [polypeptide binding]; other site 945711004668 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 945711004669 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 945711004670 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 945711004671 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 945711004672 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 945711004673 active site 945711004674 dimer interface [polypeptide binding]; other site 945711004675 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 945711004676 Ligand Binding Site [chemical binding]; other site 945711004677 Molecular Tunnel; other site 945711004678 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 945711004679 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 945711004680 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 945711004681 homotrimer interface [polypeptide binding]; other site 945711004682 Walker A motif; other site 945711004683 GTP binding site [chemical binding]; other site 945711004684 Walker B motif; other site 945711004685 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 945711004686 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 945711004687 putative dimer interface [polypeptide binding]; other site 945711004688 active site pocket [active] 945711004689 putative cataytic base [active] 945711004690 cobalamin synthase; Reviewed; Region: cobS; PRK00235 945711004691 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 945711004692 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 945711004693 homodimer interface [polypeptide binding]; other site 945711004694 substrate-cofactor binding pocket; other site 945711004695 catalytic residue [active] 945711004696 multifunctional aminopeptidase A; Provisional; Region: PRK00913 945711004697 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 945711004698 interface (dimer of trimers) [polypeptide binding]; other site 945711004699 Substrate-binding/catalytic site; other site 945711004700 Zn-binding sites [ion binding]; other site 945711004701 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 945711004702 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945711004703 E3 interaction surface; other site 945711004704 lipoyl attachment site [posttranslational modification]; other site 945711004705 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945711004706 E3 interaction surface; other site 945711004707 lipoyl attachment site [posttranslational modification]; other site 945711004708 e3 binding domain; Region: E3_binding; pfam02817 945711004709 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 945711004710 glycine dehydrogenase; Provisional; Region: PRK05367 945711004711 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 945711004712 tetramer interface [polypeptide binding]; other site 945711004713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711004714 catalytic residue [active] 945711004715 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 945711004716 tetramer interface [polypeptide binding]; other site 945711004717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711004718 catalytic residue [active] 945711004719 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 945711004720 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 945711004721 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 945711004722 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 945711004723 lipoyl attachment site [posttranslational modification]; other site 945711004724 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 945711004725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945711004726 active site 945711004727 lipoate-protein ligase B; Provisional; Region: PRK14345 945711004728 lipoyl synthase; Provisional; Region: PRK05481 945711004729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711004730 FeS/SAM binding site; other site 945711004731 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711004732 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711004733 Walker A/P-loop; other site 945711004734 ATP binding site [chemical binding]; other site 945711004735 Q-loop/lid; other site 945711004736 ABC transporter signature motif; other site 945711004737 Walker B; other site 945711004738 D-loop; other site 945711004739 H-loop/switch region; other site 945711004740 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711004741 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 945711004742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711004743 putative PBP binding regions; other site 945711004744 ABC-ATPase subunit interface; other site 945711004745 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 945711004746 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 945711004747 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711004748 ABC-ATPase subunit interface; other site 945711004749 dimer interface [polypeptide binding]; other site 945711004750 putative PBP binding regions; other site 945711004751 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 945711004752 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711004753 intersubunit interface [polypeptide binding]; other site 945711004754 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 945711004755 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 945711004756 FAD binding pocket [chemical binding]; other site 945711004757 FAD binding motif [chemical binding]; other site 945711004758 phosphate binding motif [ion binding]; other site 945711004759 NAD binding pocket [chemical binding]; other site 945711004760 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 945711004761 RDD family; Region: RDD; pfam06271 945711004762 glutamine synthetase, type I; Region: GlnA; TIGR00653 945711004763 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 945711004764 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 945711004765 Abi-like protein; Region: Abi_2; pfam07751 945711004766 Transposase; Region: DEDD_Tnp_IS110; pfam01548 945711004767 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 945711004768 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 945711004769 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 945711004770 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 945711004771 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 945711004772 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 945711004773 active site 945711004774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 945711004775 Predicted permease [General function prediction only]; Region: COG2056 945711004776 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 945711004777 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 945711004778 nudix motif; other site 945711004779 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 945711004780 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 945711004781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711004782 catalytic residue [active] 945711004783 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 945711004784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711004785 D-galactonate transporter; Region: 2A0114; TIGR00893 945711004786 putative substrate translocation pore; other site 945711004787 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 945711004788 heme binding pocket [chemical binding]; other site 945711004789 heme ligand [chemical binding]; other site 945711004790 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 945711004791 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945711004792 metal binding triad; other site 945711004793 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 945711004794 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945711004795 metal binding triad; other site 945711004796 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 945711004797 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 945711004798 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 945711004799 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 945711004800 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 945711004801 putative active site; other site 945711004802 putative metal binding residues [ion binding]; other site 945711004803 signature motif; other site 945711004804 putative triphosphate binding site [ion binding]; other site 945711004805 CHAD domain; Region: CHAD; pfam05235 945711004806 Sporulation related domain; Region: SPOR; cl10051 945711004807 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 945711004808 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 945711004809 RNB domain; Region: RNB; pfam00773 945711004810 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 945711004811 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 945711004812 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 945711004813 RNA/DNA hybrid binding site [nucleotide binding]; other site 945711004814 active site 945711004815 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711004816 catalytic core [active] 945711004817 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 945711004818 Putative zinc ribbon domain; Region: DUF164; pfam02591 945711004819 Uncharacterized conserved protein [Function unknown]; Region: COG0327 945711004820 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 945711004821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 945711004822 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 945711004823 hypothetical protein; Provisional; Region: PRK07908 945711004824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711004825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711004826 homodimer interface [polypeptide binding]; other site 945711004827 catalytic residue [active] 945711004828 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 945711004829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711004830 motif II; other site 945711004831 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 945711004832 Low molecular weight phosphatase family; Region: LMWPc; cl00105 945711004833 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 945711004834 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 945711004835 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 945711004836 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 945711004837 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 945711004838 dimer interface [polypeptide binding]; other site 945711004839 TPP-binding site [chemical binding]; other site 945711004840 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 945711004841 Serine hydrolase; Region: Ser_hydrolase; cl17834 945711004842 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 945711004843 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 945711004844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711004845 active site 945711004846 motif I; other site 945711004847 motif II; other site 945711004848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711004849 Beta-lactamase; Region: Beta-lactamase; pfam00144 945711004850 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 945711004851 Predicted membrane protein [Function unknown]; Region: COG2860 945711004852 UPF0126 domain; Region: UPF0126; pfam03458 945711004853 UPF0126 domain; Region: UPF0126; pfam03458 945711004854 DNA primase; Validated; Region: dnaG; PRK05667 945711004855 CHC2 zinc finger; Region: zf-CHC2; pfam01807 945711004856 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 945711004857 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 945711004858 active site 945711004859 metal binding site [ion binding]; metal-binding site 945711004860 interdomain interaction site; other site 945711004861 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 945711004862 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 945711004863 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 945711004864 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 945711004865 glutaminase active site [active] 945711004866 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 945711004867 dimer interface [polypeptide binding]; other site 945711004868 active site 945711004869 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 945711004870 dimer interface [polypeptide binding]; other site 945711004871 active site 945711004872 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 945711004873 active site 945711004874 barstar interaction site; other site 945711004875 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 945711004876 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945711004877 Zn2+ binding site [ion binding]; other site 945711004878 Mg2+ binding site [ion binding]; other site 945711004879 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 945711004880 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 945711004881 putative active site [active] 945711004882 Repair protein; Region: Repair_PSII; pfam04536 945711004883 glycyl-tRNA synthetase; Provisional; Region: PRK04173 945711004884 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945711004885 motif 1; other site 945711004886 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 945711004887 active site 945711004888 motif 2; other site 945711004889 motif 3; other site 945711004890 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 945711004891 anticodon binding site; other site 945711004892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945711004893 putative DNA binding site [nucleotide binding]; other site 945711004894 putative Zn2+ binding site [ion binding]; other site 945711004895 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 945711004896 metal binding site 2 [ion binding]; metal-binding site 945711004897 putative DNA binding helix; other site 945711004898 metal binding site 1 [ion binding]; metal-binding site 945711004899 dimer interface [polypeptide binding]; other site 945711004900 structural Zn2+ binding site [ion binding]; other site 945711004901 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 945711004902 diiron binding motif [ion binding]; other site 945711004903 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 945711004904 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 945711004905 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 945711004906 catalytic residue [active] 945711004907 putative FPP diphosphate binding site; other site 945711004908 putative FPP binding hydrophobic cleft; other site 945711004909 dimer interface [polypeptide binding]; other site 945711004910 putative IPP diphosphate binding site; other site 945711004911 Recombination protein O N terminal; Region: RecO_N; pfam11967 945711004912 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 945711004913 Recombination protein O C terminal; Region: RecO_C; pfam02565 945711004914 GTPase Era; Reviewed; Region: era; PRK00089 945711004915 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 945711004916 G1 box; other site 945711004917 GTP/Mg2+ binding site [chemical binding]; other site 945711004918 Switch I region; other site 945711004919 G2 box; other site 945711004920 Switch II region; other site 945711004921 G3 box; other site 945711004922 G4 box; other site 945711004923 G5 box; other site 945711004924 KH domain; Region: KH_2; pfam07650 945711004925 pyridoxamine kinase; Validated; Region: PRK05756 945711004926 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 945711004927 dimer interface [polypeptide binding]; other site 945711004928 pyridoxal binding site [chemical binding]; other site 945711004929 ATP binding site [chemical binding]; other site 945711004930 Domain of unknown function DUF21; Region: DUF21; pfam01595 945711004931 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 945711004932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 945711004933 Transporter associated domain; Region: CorC_HlyC; smart01091 945711004934 metal-binding heat shock protein; Provisional; Region: PRK00016 945711004935 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 945711004936 PhoH-like protein; Region: PhoH; pfam02562 945711004937 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 945711004938 chaperone protein DnaJ; Provisional; Region: PRK14278 945711004939 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 945711004940 HSP70 interaction site [polypeptide binding]; other site 945711004941 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 945711004942 Zn binding sites [ion binding]; other site 945711004943 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 945711004944 dimer interface [polypeptide binding]; other site 945711004945 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 945711004946 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 945711004947 coproporphyrinogen III oxidase; Validated; Region: PRK05628 945711004948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945711004949 FeS/SAM binding site; other site 945711004950 HemN C-terminal domain; Region: HemN_C; pfam06969 945711004951 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 945711004952 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 945711004953 acyl-activating enzyme (AAE) consensus motif; other site 945711004954 putative AMP binding site [chemical binding]; other site 945711004955 putative active site [active] 945711004956 putative CoA binding site [chemical binding]; other site 945711004957 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 945711004958 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 945711004959 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 945711004960 active site 945711004961 Zn binding site [ion binding]; other site 945711004962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 945711004963 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 945711004964 substrate binding pocket [chemical binding]; other site 945711004965 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 945711004966 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 945711004967 active site 945711004968 metal binding site [ion binding]; metal-binding site 945711004969 nudix motif; other site 945711004970 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945711004971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945711004972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711004973 Walker A/P-loop; other site 945711004974 ATP binding site [chemical binding]; other site 945711004975 Q-loop/lid; other site 945711004976 ABC transporter signature motif; other site 945711004977 Walker B; other site 945711004978 D-loop; other site 945711004979 H-loop/switch region; other site 945711004980 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 945711004981 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 945711004982 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 945711004983 Domain of unknown function (DUF222); Region: DUF222; pfam02720 945711004984 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945711004985 active site 945711004986 BCCT family transporter; Region: BCCT; pfam02028 945711004987 Predicted permeases [General function prediction only]; Region: COG0679 945711004988 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 945711004989 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 945711004990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711004991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711004992 dimer interface [polypeptide binding]; other site 945711004993 conserved gate region; other site 945711004994 putative PBP binding loops; other site 945711004995 ABC-ATPase subunit interface; other site 945711004996 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 945711004997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711004998 dimer interface [polypeptide binding]; other site 945711004999 conserved gate region; other site 945711005000 putative PBP binding loops; other site 945711005001 ABC-ATPase subunit interface; other site 945711005002 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 945711005003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711005004 Walker A/P-loop; other site 945711005005 ATP binding site [chemical binding]; other site 945711005006 Q-loop/lid; other site 945711005007 ABC transporter signature motif; other site 945711005008 Walker B; other site 945711005009 D-loop; other site 945711005010 H-loop/switch region; other site 945711005011 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711005012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711005013 Walker A/P-loop; other site 945711005014 ATP binding site [chemical binding]; other site 945711005015 Q-loop/lid; other site 945711005016 ABC transporter signature motif; other site 945711005017 Walker B; other site 945711005018 D-loop; other site 945711005019 H-loop/switch region; other site 945711005020 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711005021 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 945711005022 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 945711005023 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945711005024 catalytic residue [active] 945711005025 Sulphur transport; Region: Sulf_transp; pfam04143 945711005026 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 945711005027 CPxP motif; other site 945711005028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711005029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945711005030 Walker A/P-loop; other site 945711005031 ATP binding site [chemical binding]; other site 945711005032 Q-loop/lid; other site 945711005033 ABC transporter signature motif; other site 945711005034 Walker B; other site 945711005035 D-loop; other site 945711005036 H-loop/switch region; other site 945711005037 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711005038 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 945711005039 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711005040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 945711005041 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 945711005042 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 945711005043 multidrug resistance protein MdtH; Provisional; Region: PRK11646 945711005044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711005045 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 945711005046 Walker A/P-loop; other site 945711005047 ATP binding site [chemical binding]; other site 945711005048 Q-loop/lid; other site 945711005049 ABC transporter signature motif; other site 945711005050 Walker B; other site 945711005051 D-loop; other site 945711005052 H-loop/switch region; other site 945711005053 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711005054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711005055 Walker A/P-loop; other site 945711005056 ATP binding site [chemical binding]; other site 945711005057 Q-loop/lid; other site 945711005058 ABC transporter signature motif; other site 945711005059 Walker B; other site 945711005060 D-loop; other site 945711005061 H-loop/switch region; other site 945711005062 GTP-binding protein LepA; Provisional; Region: PRK05433 945711005063 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 945711005064 G1 box; other site 945711005065 putative GEF interaction site [polypeptide binding]; other site 945711005066 GTP/Mg2+ binding site [chemical binding]; other site 945711005067 Switch I region; other site 945711005068 G2 box; other site 945711005069 G3 box; other site 945711005070 Switch II region; other site 945711005071 G4 box; other site 945711005072 G5 box; other site 945711005073 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 945711005074 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 945711005075 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 945711005076 PemK-like protein; Region: PemK; pfam02452 945711005077 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 945711005078 LysE type translocator; Region: LysE; cl00565 945711005079 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 945711005080 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 945711005081 hypothetical protein; Validated; Region: PRK05629 945711005082 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 945711005083 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 945711005084 Competence protein; Region: Competence; pfam03772 945711005085 comEA protein; Region: comE; TIGR01259 945711005086 Helix-hairpin-helix motif; Region: HHH; pfam00633 945711005087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 945711005088 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 945711005089 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711005090 catalytic core [active] 945711005091 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 945711005092 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 945711005093 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 945711005094 active site 945711005095 (T/H)XGH motif; other site 945711005096 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 945711005097 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 945711005098 putative catalytic cysteine [active] 945711005099 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 945711005100 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 945711005101 putative ligand binding site [chemical binding]; other site 945711005102 putative NAD binding site [chemical binding]; other site 945711005103 catalytic site [active] 945711005104 Protein of unknown function (DUF454); Region: DUF454; cl01063 945711005105 putative transporter; Validated; Region: PRK03818 945711005106 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 945711005107 TrkA-C domain; Region: TrkA_C; pfam02080 945711005108 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 945711005109 gamma-glutamyl kinase; Provisional; Region: PRK05429 945711005110 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 945711005111 nucleotide binding site [chemical binding]; other site 945711005112 homotetrameric interface [polypeptide binding]; other site 945711005113 putative phosphate binding site [ion binding]; other site 945711005114 putative allosteric binding site; other site 945711005115 PUA domain; Region: PUA; pfam01472 945711005116 GTPase CgtA; Reviewed; Region: obgE; PRK12296 945711005117 GTP1/OBG; Region: GTP1_OBG; pfam01018 945711005118 Obg GTPase; Region: Obg; cd01898 945711005119 G1 box; other site 945711005120 GTP/Mg2+ binding site [chemical binding]; other site 945711005121 Switch I region; other site 945711005122 G2 box; other site 945711005123 G3 box; other site 945711005124 Switch II region; other site 945711005125 G4 box; other site 945711005126 G5 box; other site 945711005127 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 945711005128 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 945711005129 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 945711005130 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 945711005131 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 945711005132 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 945711005133 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 945711005134 homodimer interface [polypeptide binding]; other site 945711005135 oligonucleotide binding site [chemical binding]; other site 945711005136 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 945711005137 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 945711005138 active site 945711005139 multimer interface [polypeptide binding]; other site 945711005140 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 945711005141 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 945711005142 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 945711005143 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 945711005144 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945711005145 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945711005146 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 945711005147 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711005148 active site 945711005149 HIGH motif; other site 945711005150 nucleotide binding site [chemical binding]; other site 945711005151 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 945711005152 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 945711005153 active site 945711005154 KMSKS motif; other site 945711005155 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 945711005156 tRNA binding surface [nucleotide binding]; other site 945711005157 anticodon binding site; other site 945711005158 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 945711005159 malate dehydrogenase; Provisional; Region: PRK05442 945711005160 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 945711005161 NAD(P) binding site [chemical binding]; other site 945711005162 dimer interface [polypeptide binding]; other site 945711005163 malate binding site [chemical binding]; other site 945711005164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711005165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711005166 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 945711005167 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 945711005168 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 945711005169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711005170 Walker A motif; other site 945711005171 ATP binding site [chemical binding]; other site 945711005172 Walker B motif; other site 945711005173 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 945711005174 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 945711005175 Glutamine amidotransferase class-I; Region: GATase; pfam00117 945711005176 glutamine binding [chemical binding]; other site 945711005177 catalytic triad [active] 945711005178 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 945711005179 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 945711005180 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 945711005181 substrate-cofactor binding pocket; other site 945711005182 Aminotransferase class IV; Region: Aminotran_4; pfam01063 945711005183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711005184 catalytic residue [active] 945711005185 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 945711005186 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 945711005187 oligomer interface [polypeptide binding]; other site 945711005188 active site residues [active] 945711005189 Clp protease; Region: CLP_protease; pfam00574 945711005190 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 945711005191 oligomer interface [polypeptide binding]; other site 945711005192 active site residues [active] 945711005193 trigger factor; Provisional; Region: tig; PRK01490 945711005194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 945711005195 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 945711005196 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 945711005197 Pirin-related protein [General function prediction only]; Region: COG1741 945711005198 Pirin; Region: Pirin; pfam02678 945711005199 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 945711005200 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 945711005201 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 945711005202 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 945711005203 catalytic residues [active] 945711005204 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 945711005205 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 945711005206 Zn binding site [ion binding]; other site 945711005207 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 945711005208 Mechanosensitive ion channel; Region: MS_channel; pfam00924 945711005209 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 945711005210 apolar tunnel; other site 945711005211 heme binding site [chemical binding]; other site 945711005212 dimerization interface [polypeptide binding]; other site 945711005213 Protein of unknown function, DUF606; Region: DUF606; pfam04657 945711005214 Protein of unknown function, DUF606; Region: DUF606; pfam04657 945711005215 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 945711005216 active site 945711005217 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 945711005218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711005219 Walker A/P-loop; other site 945711005220 ATP binding site [chemical binding]; other site 945711005221 Q-loop/lid; other site 945711005222 ABC transporter signature motif; other site 945711005223 Walker B; other site 945711005224 D-loop; other site 945711005225 H-loop/switch region; other site 945711005226 ABC transporter; Region: ABC_tran_2; pfam12848 945711005227 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945711005228 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 945711005229 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 945711005230 dimer interface [polypeptide binding]; other site 945711005231 ssDNA binding site [nucleotide binding]; other site 945711005232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945711005233 YcaO-like family; Region: YcaO; pfam02624 945711005234 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 945711005235 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 945711005236 NADPH bind site [chemical binding]; other site 945711005237 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 945711005238 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 945711005239 SpaB C-terminal domain; Region: SpaB_C; pfam14028 945711005240 YcaO-like family; Region: YcaO; pfam02624 945711005241 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 945711005242 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711005243 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945711005244 Walker A/P-loop; other site 945711005245 ATP binding site [chemical binding]; other site 945711005246 Q-loop/lid; other site 945711005247 ABC transporter signature motif; other site 945711005248 Walker B; other site 945711005249 D-loop; other site 945711005250 H-loop/switch region; other site 945711005251 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 945711005252 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 945711005253 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 945711005254 Carbon starvation protein CstA; Region: CstA; pfam02554 945711005255 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 945711005256 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 945711005257 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 945711005258 active site 945711005259 catalytic triad [active] 945711005260 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 945711005261 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 945711005262 NADP binding site [chemical binding]; other site 945711005263 dimer interface [polypeptide binding]; other site 945711005264 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 945711005265 classical (c) SDRs; Region: SDR_c; cd05233 945711005266 NAD(P) binding site [chemical binding]; other site 945711005267 active site 945711005268 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 945711005269 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 945711005270 catalytic site [active] 945711005271 putative active site [active] 945711005272 putative substrate binding site [chemical binding]; other site 945711005273 dimer interface [polypeptide binding]; other site 945711005274 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 945711005275 N-acetylneuraminate lyase; Provisional; Region: PRK04147 945711005276 inhibitor site; inhibition site 945711005277 active site 945711005278 dimer interface [polypeptide binding]; other site 945711005279 catalytic residue [active] 945711005280 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 945711005281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 945711005282 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 945711005283 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 945711005284 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 945711005285 Prostaglandin dehydrogenases; Region: PGDH; cd05288 945711005286 NAD(P) binding site [chemical binding]; other site 945711005287 substrate binding site [chemical binding]; other site 945711005288 dimer interface [polypeptide binding]; other site 945711005289 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 945711005290 Isochorismatase family; Region: Isochorismatase; pfam00857 945711005291 catalytic triad [active] 945711005292 metal binding site [ion binding]; metal-binding site 945711005293 conserved cis-peptide bond; other site 945711005294 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 945711005295 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 945711005296 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 945711005297 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 945711005298 catalytic triad [active] 945711005299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711005300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711005301 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 945711005302 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 945711005303 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 945711005304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 945711005305 phosphate binding site [ion binding]; other site 945711005306 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 945711005307 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 945711005308 active site 2 [active] 945711005309 active site 1 [active] 945711005310 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 945711005311 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 945711005312 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 945711005313 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 945711005314 putative NAD(P) binding site [chemical binding]; other site 945711005315 active site 945711005316 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 945711005317 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 945711005318 active site 945711005320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711005321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711005322 active site 945711005323 phosphorylation site [posttranslational modification] 945711005324 intermolecular recognition site; other site 945711005325 dimerization interface [polypeptide binding]; other site 945711005326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711005327 DNA binding residues [nucleotide binding] 945711005328 dimerization interface [polypeptide binding]; other site 945711005329 Protein of unknown function (DUF418); Region: DUF418; cl12135 945711005330 Protein of unknown function (DUF418); Region: DUF418; pfam04235 945711005331 Glucitol operon activator protein (GutM); Region: GutM; cl01890 945711005332 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 945711005333 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 945711005334 active site 945711005335 dimerization interface [polypeptide binding]; other site 945711005336 ribonuclease PH; Reviewed; Region: rph; PRK00173 945711005337 Ribonuclease PH; Region: RNase_PH_bact; cd11362 945711005338 hexamer interface [polypeptide binding]; other site 945711005339 active site 945711005340 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 945711005341 glutamate racemase; Provisional; Region: PRK00865 945711005342 Rhomboid family; Region: Rhomboid; cl11446 945711005343 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 945711005344 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 945711005345 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 945711005346 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 945711005347 active site 945711005348 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 945711005349 DEAD/DEAH box helicase; Region: DEAD; pfam00270 945711005350 ATP binding site [chemical binding]; other site 945711005351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 945711005352 putative Mg++ binding site [ion binding]; other site 945711005353 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 945711005354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 945711005355 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 945711005356 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 945711005357 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 945711005358 phosphoserine phosphatase SerB; Region: serB; TIGR00338 945711005359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711005360 motif II; other site 945711005361 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 945711005362 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 945711005363 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 945711005364 D-pathway; other site 945711005365 Putative ubiquinol binding site [chemical binding]; other site 945711005366 Low-spin heme (heme b) binding site [chemical binding]; other site 945711005367 Putative water exit pathway; other site 945711005368 Binuclear center (heme o3/CuB) [ion binding]; other site 945711005369 K-pathway; other site 945711005370 Putative proton exit pathway; other site 945711005371 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 945711005372 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 945711005373 dimer interface [polypeptide binding]; other site 945711005374 putative radical transfer pathway; other site 945711005375 diiron center [ion binding]; other site 945711005376 tyrosyl radical; other site 945711005377 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 945711005378 Ferritin-like domain; Region: Ferritin; pfam00210 945711005379 ferroxidase diiron center [ion binding]; other site 945711005380 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 945711005381 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 945711005382 Class I ribonucleotide reductase; Region: RNR_I; cd01679 945711005383 active site 945711005384 dimer interface [polypeptide binding]; other site 945711005385 catalytic residues [active] 945711005386 effector binding site; other site 945711005387 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 945711005388 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 945711005389 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 945711005390 catalytic residues [active] 945711005391 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 945711005392 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 945711005393 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 945711005394 homodimer interface [polypeptide binding]; other site 945711005395 NAD binding pocket [chemical binding]; other site 945711005396 ATP binding pocket [chemical binding]; other site 945711005397 Mg binding site [ion binding]; other site 945711005398 active-site loop [active] 945711005399 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 945711005400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945711005401 dimerization interface [polypeptide binding]; other site 945711005402 putative DNA binding site [nucleotide binding]; other site 945711005403 putative Zn2+ binding site [ion binding]; other site 945711005404 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 945711005405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945711005406 Soluble P-type ATPase [General function prediction only]; Region: COG4087 945711005407 Thioredoxin; Region: Thioredoxin_4; cl17273 945711005408 Predicted membrane protein [Function unknown]; Region: COG2259 945711005409 phosphoglucomutase; Validated; Region: PRK07564 945711005410 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 945711005411 active site 945711005412 substrate binding site [chemical binding]; other site 945711005413 metal binding site [ion binding]; metal-binding site 945711005414 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 945711005415 CrcB-like protein; Region: CRCB; pfam02537 945711005416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945711005417 FtsX-like permease family; Region: FtsX; pfam02687 945711005418 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945711005419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945711005420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711005421 Walker A/P-loop; other site 945711005422 ATP binding site [chemical binding]; other site 945711005423 Q-loop/lid; other site 945711005424 ABC transporter signature motif; other site 945711005425 Walker B; other site 945711005426 D-loop; other site 945711005427 H-loop/switch region; other site 945711005428 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 945711005429 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 945711005430 hinge; other site 945711005431 active site 945711005432 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 945711005433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711005434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711005435 DNA binding residues [nucleotide binding] 945711005436 dimerization interface [polypeptide binding]; other site 945711005437 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 945711005438 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 945711005439 dimer interface [polypeptide binding]; other site 945711005440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711005441 catalytic residue [active] 945711005442 serine O-acetyltransferase; Region: cysE; TIGR01172 945711005443 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 945711005444 trimer interface [polypeptide binding]; other site 945711005445 active site 945711005446 substrate binding site [chemical binding]; other site 945711005447 CoA binding site [chemical binding]; other site 945711005448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945711005449 Coenzyme A binding pocket [chemical binding]; other site 945711005450 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 945711005451 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 945711005452 putative active site [active] 945711005453 metal binding site [ion binding]; metal-binding site 945711005454 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 945711005455 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 945711005456 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 945711005457 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 945711005458 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 945711005459 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 945711005460 Walker A/P-loop; other site 945711005461 ATP binding site [chemical binding]; other site 945711005462 Q-loop/lid; other site 945711005463 ABC transporter signature motif; other site 945711005464 Walker B; other site 945711005465 D-loop; other site 945711005466 H-loop/switch region; other site 945711005467 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 945711005468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711005469 Walker A/P-loop; other site 945711005470 ATP binding site [chemical binding]; other site 945711005471 Q-loop/lid; other site 945711005472 ABC transporter signature motif; other site 945711005473 Walker B; other site 945711005474 D-loop; other site 945711005475 H-loop/switch region; other site 945711005476 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 945711005477 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 945711005478 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 945711005479 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 945711005480 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 945711005481 FMN binding site [chemical binding]; other site 945711005482 active site 945711005483 catalytic residues [active] 945711005484 substrate binding site [chemical binding]; other site 945711005485 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 945711005486 PhoU domain; Region: PhoU; pfam01895 945711005487 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 945711005488 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 945711005489 Walker A/P-loop; other site 945711005490 ATP binding site [chemical binding]; other site 945711005491 Q-loop/lid; other site 945711005492 ABC transporter signature motif; other site 945711005493 Walker B; other site 945711005494 D-loop; other site 945711005495 H-loop/switch region; other site 945711005496 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 945711005497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711005498 dimer interface [polypeptide binding]; other site 945711005499 conserved gate region; other site 945711005500 putative PBP binding loops; other site 945711005501 ABC-ATPase subunit interface; other site 945711005502 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 945711005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711005504 dimer interface [polypeptide binding]; other site 945711005505 conserved gate region; other site 945711005506 putative PBP binding loops; other site 945711005507 ABC-ATPase subunit interface; other site 945711005508 PBP superfamily domain; Region: PBP_like_2; cl17296 945711005509 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 945711005510 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 945711005511 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 945711005512 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 945711005513 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 945711005514 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 945711005515 heme-binding site [chemical binding]; other site 945711005516 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 945711005517 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 945711005518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711005519 catalytic residue [active] 945711005520 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 945711005521 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 945711005522 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 945711005523 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 945711005524 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 945711005525 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 945711005526 dimerization interface [polypeptide binding]; other site 945711005527 putative ATP binding site [chemical binding]; other site 945711005528 amidophosphoribosyltransferase; Provisional; Region: PRK07847 945711005529 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 945711005530 active site 945711005531 tetramer interface [polypeptide binding]; other site 945711005532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711005533 active site 945711005534 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 945711005535 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 945711005536 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 945711005537 dimer interface [polypeptide binding]; other site 945711005538 putative radical transfer pathway; other site 945711005539 diiron center [ion binding]; other site 945711005540 tyrosyl radical; other site 945711005541 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 945711005542 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 945711005543 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 945711005544 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 945711005545 dimerization interface [polypeptide binding]; other site 945711005546 ATP binding site [chemical binding]; other site 945711005547 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 945711005548 dimerization interface [polypeptide binding]; other site 945711005549 ATP binding site [chemical binding]; other site 945711005550 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 945711005551 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 945711005552 putative active site [active] 945711005553 catalytic triad [active] 945711005554 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 945711005555 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 945711005556 catalytic residues [active] 945711005557 dimer interface [polypeptide binding]; other site 945711005558 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 945711005559 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945711005560 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 945711005561 ATP binding site [chemical binding]; other site 945711005562 active site 945711005563 substrate binding site [chemical binding]; other site 945711005564 adenylosuccinate lyase; Region: purB; TIGR00928 945711005565 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 945711005566 tetramer interface [polypeptide binding]; other site 945711005567 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 945711005568 TrkA-N domain; Region: TrkA_N; pfam02254 945711005569 TrkA-C domain; Region: TrkA_C; pfam02080 945711005570 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 945711005571 Cation transport protein; Region: TrkH; cl17365 945711005572 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 945711005573 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 945711005574 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 945711005575 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 945711005576 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 945711005577 nucleotide binding site/active site [active] 945711005578 HIT family signature motif; other site 945711005579 catalytic residue [active] 945711005580 PGAP1-like protein; Region: PGAP1; pfam07819 945711005581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 945711005582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945711005583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945711005584 dimerization interface [polypeptide binding]; other site 945711005585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945711005586 dimer interface [polypeptide binding]; other site 945711005587 phosphorylation site [posttranslational modification] 945711005588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711005589 ATP binding site [chemical binding]; other site 945711005590 Mg2+ binding site [ion binding]; other site 945711005591 G-X-G motif; other site 945711005592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945711005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711005594 active site 945711005595 phosphorylation site [posttranslational modification] 945711005596 intermolecular recognition site; other site 945711005597 dimerization interface [polypeptide binding]; other site 945711005598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945711005599 DNA binding site [nucleotide binding] 945711005600 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 945711005601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711005602 putative substrate translocation pore; other site 945711005603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711005604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711005605 Putative esterase; Region: Esterase; pfam00756 945711005606 S-formylglutathione hydrolase; Region: PLN02442 945711005607 xanthine permease; Region: pbuX; TIGR03173 945711005608 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 945711005609 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 945711005610 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 945711005611 putative active site [active] 945711005612 pyruvate dehydrogenase; Provisional; Region: PRK06546 945711005613 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 945711005614 PYR/PP interface [polypeptide binding]; other site 945711005615 tetramer interface [polypeptide binding]; other site 945711005616 dimer interface [polypeptide binding]; other site 945711005617 TPP binding site [chemical binding]; other site 945711005618 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 945711005619 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 945711005620 TPP-binding site [chemical binding]; other site 945711005621 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 945711005622 Uncharacterized conserved protein [Function unknown]; Region: COG3610 945711005623 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 945711005624 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 945711005625 Uncharacterized conserved protein [Function unknown]; Region: COG2966 945711005626 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 945711005627 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 945711005628 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 945711005629 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 945711005630 active site 945711005631 homotetramer interface [polypeptide binding]; other site 945711005632 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 945711005633 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 945711005634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 945711005635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 945711005636 DNA binding site [nucleotide binding] 945711005637 domain linker motif; other site 945711005638 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 945711005639 putative dimerization interface [polypeptide binding]; other site 945711005640 putative ligand binding site [chemical binding]; other site 945711005641 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 945711005642 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 945711005643 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 945711005644 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945711005645 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 945711005646 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711005647 active site 945711005648 HIGH motif; other site 945711005649 nucleotide binding site [chemical binding]; other site 945711005650 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 945711005651 KMSKS motif; other site 945711005652 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 945711005653 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 945711005654 homotrimer interaction site [polypeptide binding]; other site 945711005655 zinc binding site [ion binding]; other site 945711005656 CDP-binding sites; other site 945711005657 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 945711005658 substrate binding site; other site 945711005659 dimer interface; other site 945711005660 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 945711005661 flagellar hook protein FlgE, epsilon proteobacterial; Region: flgE_epsilon; TIGR02489 945711005662 DNA repair protein RadA; Provisional; Region: PRK11823 945711005663 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 945711005664 Walker A motif; other site 945711005665 ATP binding site [chemical binding]; other site 945711005666 Walker B motif; other site 945711005667 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 945711005668 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 945711005669 active site clefts [active] 945711005670 zinc binding site [ion binding]; other site 945711005671 dimer interface [polypeptide binding]; other site 945711005672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 945711005673 endonuclease III; Region: ENDO3c; smart00478 945711005674 minor groove reading motif; other site 945711005675 helix-hairpin-helix signature motif; other site 945711005676 substrate binding pocket [chemical binding]; other site 945711005677 active site 945711005678 Uncharacterized conserved protein [Function unknown]; Region: COG2966 945711005679 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 945711005680 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 945711005681 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 945711005682 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 945711005683 Clp amino terminal domain; Region: Clp_N; pfam02861 945711005684 Clp amino terminal domain; Region: Clp_N; pfam02861 945711005685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711005686 Walker A motif; other site 945711005687 ATP binding site [chemical binding]; other site 945711005688 Walker B motif; other site 945711005689 arginine finger; other site 945711005690 UvrB/uvrC motif; Region: UVR; pfam02151 945711005691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711005692 Walker A motif; other site 945711005693 ATP binding site [chemical binding]; other site 945711005694 Walker B motif; other site 945711005695 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 945711005696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711005697 putative substrate translocation pore; other site 945711005698 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 945711005699 active site 945711005700 tetramer interface [polypeptide binding]; other site 945711005701 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 945711005702 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 945711005703 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 945711005704 Mnd1 family; Region: Mnd1; pfam03962 945711005705 Trypsin; Region: Trypsin; pfam00089 945711005706 active site 945711005707 substrate binding sites [chemical binding]; other site 945711005708 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 945711005709 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 945711005710 dimer interface [polypeptide binding]; other site 945711005711 putative anticodon binding site; other site 945711005712 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945711005713 motif 1; other site 945711005714 dimer interface [polypeptide binding]; other site 945711005715 active site 945711005716 motif 2; other site 945711005717 motif 3; other site 945711005718 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 945711005719 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 945711005720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 945711005721 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 945711005722 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 945711005723 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 945711005724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 945711005725 NAD(P) binding site [chemical binding]; other site 945711005726 catalytic residues [active] 945711005727 BCCT family transporter; Region: BCCT; cl00569 945711005728 choline dehydrogenase; Validated; Region: PRK02106 945711005729 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 945711005730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711005731 pantoate--beta-alanine ligase; Region: panC; TIGR00018 945711005732 active site 945711005733 nucleotide binding site [chemical binding]; other site 945711005734 HIGH motif; other site 945711005735 KMSKS motif; other site 945711005736 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 945711005737 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 945711005738 catalytic center binding site [active] 945711005739 ATP binding site [chemical binding]; other site 945711005740 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 945711005741 homooctamer interface [polypeptide binding]; other site 945711005742 active site 945711005743 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 945711005744 dihydropteroate synthase; Region: DHPS; TIGR01496 945711005745 substrate binding pocket [chemical binding]; other site 945711005746 dimer interface [polypeptide binding]; other site 945711005747 inhibitor binding site; inhibition site 945711005748 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 945711005749 homodecamer interface [polypeptide binding]; other site 945711005750 GTP cyclohydrolase I; Provisional; Region: PLN03044 945711005751 active site 945711005752 putative catalytic site residues [active] 945711005753 zinc binding site [ion binding]; other site 945711005754 GTP-CH-I/GFRP interaction surface; other site 945711005755 FtsH Extracellular; Region: FtsH_ext; pfam06480 945711005756 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 945711005757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711005758 Walker A motif; other site 945711005759 ATP binding site [chemical binding]; other site 945711005760 Walker B motif; other site 945711005761 arginine finger; other site 945711005762 Peptidase family M41; Region: Peptidase_M41; pfam01434 945711005763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711005764 active site 945711005765 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 945711005766 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 945711005767 Ligand Binding Site [chemical binding]; other site 945711005768 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 945711005769 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 945711005770 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 945711005771 dimer interface [polypeptide binding]; other site 945711005772 substrate binding site [chemical binding]; other site 945711005773 metal binding sites [ion binding]; metal-binding site 945711005774 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 945711005775 active site residue [active] 945711005776 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 945711005777 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 945711005778 Secretory lipase; Region: LIP; pfam03583 945711005779 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945711005780 MarR family; Region: MarR_2; pfam12802 945711005781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945711005782 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 945711005783 acyl-activating enzyme (AAE) consensus motif; other site 945711005784 AMP binding site [chemical binding]; other site 945711005785 active site 945711005786 CoA binding site [chemical binding]; other site 945711005787 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 945711005788 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 945711005789 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945711005790 putative trimer interface [polypeptide binding]; other site 945711005791 putative CoA binding site [chemical binding]; other site 945711005792 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945711005793 putative trimer interface [polypeptide binding]; other site 945711005794 putative CoA binding site [chemical binding]; other site 945711005795 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 945711005796 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 945711005797 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 945711005798 ring oligomerisation interface [polypeptide binding]; other site 945711005799 ATP/Mg binding site [chemical binding]; other site 945711005800 stacking interactions; other site 945711005801 hinge regions; other site 945711005802 hypothetical protein; Provisional; Region: PRK07907 945711005803 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 945711005804 active site 945711005805 metal binding site [ion binding]; metal-binding site 945711005806 dimer interface [polypeptide binding]; other site 945711005807 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 945711005808 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945711005809 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 945711005810 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 945711005811 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 945711005812 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 945711005813 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 945711005814 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945711005815 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 945711005816 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 945711005817 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 945711005818 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 945711005819 carboxylate-amine ligase; Provisional; Region: PRK13517 945711005820 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 945711005821 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 945711005822 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 945711005823 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 945711005824 active site 945711005825 catalytic residues [active] 945711005826 metal binding site [ion binding]; metal-binding site 945711005827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945711005828 Coenzyme A binding pocket [chemical binding]; other site 945711005829 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 945711005830 putative catalytic site [active] 945711005831 putative phosphate binding site [ion binding]; other site 945711005832 active site 945711005833 metal binding site A [ion binding]; metal-binding site 945711005834 DNA binding site [nucleotide binding] 945711005835 putative AP binding site [nucleotide binding]; other site 945711005836 putative metal binding site B [ion binding]; other site 945711005837 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 945711005838 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 945711005839 putative active site [active] 945711005840 catalytic site [active] 945711005841 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 945711005842 putative active site [active] 945711005843 catalytic site [active] 945711005844 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 945711005845 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711005846 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 945711005847 Walker A/P-loop; other site 945711005848 ATP binding site [chemical binding]; other site 945711005849 Q-loop/lid; other site 945711005850 ABC transporter signature motif; other site 945711005851 Walker B; other site 945711005852 D-loop; other site 945711005853 H-loop/switch region; other site 945711005854 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 945711005855 nudix motif; other site 945711005856 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 945711005857 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 945711005858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 945711005859 substrate binding pocket [chemical binding]; other site 945711005860 membrane-bound complex binding site; other site 945711005861 hinge residues; other site 945711005862 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 945711005863 Catalytic domain of Protein Kinases; Region: PKc; cd00180 945711005864 active site 945711005865 ATP binding site [chemical binding]; other site 945711005866 substrate binding site [chemical binding]; other site 945711005867 activation loop (A-loop); other site 945711005868 propionate/acetate kinase; Provisional; Region: PRK12379 945711005869 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 945711005870 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 945711005871 ferredoxin-NADP+ reductase; Region: PLN02852 945711005872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945711005873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 945711005874 Coenzyme A binding pocket [chemical binding]; other site 945711005875 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945711005876 active site 945711005877 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 945711005878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945711005879 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 945711005880 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711005881 active site 945711005882 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 945711005883 Protease prsW family; Region: PrsW-protease; pfam13367 945711005884 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 945711005885 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945711005886 catalytic residues [active] 945711005887 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 945711005888 ResB-like family; Region: ResB; pfam05140 945711005889 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 945711005890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945711005891 TPR motif; other site 945711005892 TPR repeat; Region: TPR_11; pfam13414 945711005893 binding surface 945711005894 Cytochrome c552; Region: Cytochrom_C552; pfam02335 945711005895 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 945711005896 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 945711005897 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 945711005898 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 945711005899 GDP-binding site [chemical binding]; other site 945711005900 ACT binding site; other site 945711005901 IMP binding site; other site 945711005902 Predicted membrane protein [Function unknown]; Region: COG4129 945711005903 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 945711005904 Predicted membrane protein [Function unknown]; Region: COG4129 945711005905 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 945711005906 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 945711005907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945711005908 Walker A/P-loop; other site 945711005909 ATP binding site [chemical binding]; other site 945711005910 Q-loop/lid; other site 945711005911 ABC transporter signature motif; other site 945711005912 Walker B; other site 945711005913 D-loop; other site 945711005914 H-loop/switch region; other site 945711005915 Predicted transcriptional regulators [Transcription]; Region: COG1695 945711005916 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 945711005917 Cna protein B-type domain; Region: Cna_B; pfam05738 945711005918 Cna protein B-type domain; Region: Cna_B; pfam05738 945711005919 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945711005920 Cna protein B-type domain; Region: Cna_B; pfam05738 945711005921 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945711005922 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 945711005923 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 945711005924 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 945711005925 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 945711005926 active site 945711005927 intersubunit interface [polypeptide binding]; other site 945711005928 zinc binding site [ion binding]; other site 945711005929 Na+ binding site [ion binding]; other site 945711005930 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 945711005931 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 945711005932 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 945711005933 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945711005934 active site 945711005935 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 945711005936 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 945711005937 active site residue [active] 945711005938 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 945711005939 active site residue [active] 945711005940 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 945711005941 Uncharacterized conserved protein [Function unknown]; Region: COG1434 945711005942 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 945711005943 putative active site [active] 945711005944 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 945711005945 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 945711005946 active site 945711005947 catalytic site [active] 945711005948 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 945711005949 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 945711005950 active site 945711005951 catalytic site [active] 945711005952 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 945711005953 Clp amino terminal domain; Region: Clp_N; pfam02861 945711005954 Clp amino terminal domain; Region: Clp_N; pfam02861 945711005955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711005956 Walker A motif; other site 945711005957 ATP binding site [chemical binding]; other site 945711005958 Walker B motif; other site 945711005959 arginine finger; other site 945711005960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945711005961 Walker A motif; other site 945711005962 ATP binding site [chemical binding]; other site 945711005963 Walker B motif; other site 945711005964 arginine finger; other site 945711005965 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 945711005966 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 945711005967 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945711005968 Walker A/P-loop; other site 945711005969 ATP binding site [chemical binding]; other site 945711005970 Q-loop/lid; other site 945711005971 ABC transporter signature motif; other site 945711005972 Walker B; other site 945711005973 D-loop; other site 945711005974 H-loop/switch region; other site 945711005975 Mnd1 family; Region: Mnd1; pfam03962 945711005976 Septum formation initiator; Region: DivIC; cl17659 945711005977 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 945711005978 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 945711005979 FAD binding pocket [chemical binding]; other site 945711005980 conserved FAD binding motif [chemical binding]; other site 945711005981 phosphate binding motif [ion binding]; other site 945711005982 beta-alpha-beta structure motif; other site 945711005983 NAD binding pocket [chemical binding]; other site 945711005984 CAAX protease self-immunity; Region: Abi; pfam02517 945711005985 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 945711005986 active site 945711005987 substrate binding sites [chemical binding]; other site 945711005988 Protein of unknown function (DUF418); Region: DUF418; cl12135 945711005989 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945711005990 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 945711005991 FtsX-like permease family; Region: FtsX; pfam02687 945711005992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711005993 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945711005994 Walker A/P-loop; other site 945711005995 ATP binding site [chemical binding]; other site 945711005996 Q-loop/lid; other site 945711005997 ABC transporter signature motif; other site 945711005998 Walker B; other site 945711005999 D-loop; other site 945711006000 H-loop/switch region; other site 945711006001 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 945711006002 HlyD family secretion protein; Region: HlyD_3; pfam13437 945711006003 Predicted amidohydrolase [General function prediction only]; Region: COG0388 945711006004 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 945711006005 putative active site [active] 945711006006 catalytic triad [active] 945711006007 putative dimer interface [polypeptide binding]; other site 945711006008 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 945711006009 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 945711006010 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 945711006011 NAD binding site [chemical binding]; other site 945711006012 substrate binding site [chemical binding]; other site 945711006013 catalytic Zn binding site [ion binding]; other site 945711006014 tetramer interface [polypeptide binding]; other site 945711006015 structural Zn binding site [ion binding]; other site 945711006016 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 945711006017 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 945711006018 NAD(P) binding site [chemical binding]; other site 945711006019 catalytic residues [active] 945711006020 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 945711006021 active site 945711006022 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 945711006023 DNA binding residues [nucleotide binding] 945711006024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945711006025 putative dimer interface [polypeptide binding]; other site 945711006026 chaperone protein DnaJ; Provisional; Region: PRK14279 945711006027 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 945711006028 HSP70 interaction site [polypeptide binding]; other site 945711006029 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 945711006030 Zn binding sites [ion binding]; other site 945711006031 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 945711006032 dimer interface [polypeptide binding]; other site 945711006033 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 945711006034 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 945711006035 dimer interface [polypeptide binding]; other site 945711006036 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 945711006037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 945711006038 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 945711006039 nucleotide binding site [chemical binding]; other site 945711006040 NEF interaction site [polypeptide binding]; other site 945711006041 SBD interface [polypeptide binding]; other site 945711006042 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 945711006043 metal ion-dependent adhesion site (MIDAS); other site 945711006044 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 945711006045 active site 945711006046 catalytic site [active] 945711006047 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 945711006048 Domain of unknown function DUF20; Region: UPF0118; pfam01594 945711006049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711006050 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 945711006051 Walker A/P-loop; other site 945711006052 ATP binding site [chemical binding]; other site 945711006053 Q-loop/lid; other site 945711006054 ABC transporter signature motif; other site 945711006055 Walker B; other site 945711006056 D-loop; other site 945711006057 H-loop/switch region; other site 945711006058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711006060 dimer interface [polypeptide binding]; other site 945711006061 conserved gate region; other site 945711006062 putative PBP binding loops; other site 945711006063 ABC-ATPase subunit interface; other site 945711006064 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 945711006065 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711006066 Walker A/P-loop; other site 945711006067 ATP binding site [chemical binding]; other site 945711006068 Q-loop/lid; other site 945711006069 ABC transporter signature motif; other site 945711006070 Walker B; other site 945711006071 D-loop; other site 945711006072 H-loop/switch region; other site 945711006073 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711006074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711006075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711006076 dimer interface [polypeptide binding]; other site 945711006077 conserved gate region; other site 945711006078 putative PBP binding loops; other site 945711006079 ABC-ATPase subunit interface; other site 945711006080 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 945711006081 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 945711006082 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 945711006083 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 945711006084 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 945711006085 4Fe-4S binding domain; Region: Fer4; cl02805 945711006086 4Fe-4S binding domain; Region: Fer4; pfam00037 945711006087 Cysteine-rich domain; Region: CCG; pfam02754 945711006088 Cysteine-rich domain; Region: CCG; pfam02754 945711006089 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 945711006090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945711006091 dimerization interface [polypeptide binding]; other site 945711006092 putative DNA binding site [nucleotide binding]; other site 945711006093 putative Zn2+ binding site [ion binding]; other site 945711006094 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711006095 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711006096 Walker A/P-loop; other site 945711006097 ATP binding site [chemical binding]; other site 945711006098 Q-loop/lid; other site 945711006099 ABC transporter signature motif; other site 945711006100 Walker B; other site 945711006101 D-loop; other site 945711006102 H-loop/switch region; other site 945711006103 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711006104 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711006105 putative PBP binding regions; other site 945711006106 ABC-ATPase subunit interface; other site 945711006107 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 945711006108 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945711006109 intersubunit interface [polypeptide binding]; other site 945711006110 UreD urease accessory protein; Region: UreD; pfam01774 945711006111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 945711006112 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 945711006113 UreF; Region: UreF; pfam01730 945711006114 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 945711006115 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 945711006116 dimer interface [polypeptide binding]; other site 945711006117 catalytic residues [active] 945711006118 urease subunit alpha; Reviewed; Region: ureC; PRK13207 945711006119 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 945711006120 subunit interactions [polypeptide binding]; other site 945711006121 active site 945711006122 flap region; other site 945711006123 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 945711006124 gamma-beta subunit interface [polypeptide binding]; other site 945711006125 alpha-beta subunit interface [polypeptide binding]; other site 945711006126 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 945711006127 alpha-gamma subunit interface [polypeptide binding]; other site 945711006128 beta-gamma subunit interface [polypeptide binding]; other site 945711006129 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 945711006130 EamA-like transporter family; Region: EamA; pfam00892 945711006131 EamA-like transporter family; Region: EamA; pfam00892 945711006132 aminotransferase AlaT; Validated; Region: PRK09265 945711006133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945711006134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711006135 homodimer interface [polypeptide binding]; other site 945711006136 catalytic residue [active] 945711006137 YibE/F-like protein; Region: YibE_F; pfam07907 945711006138 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 945711006139 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 945711006140 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 945711006141 dimer interface [polypeptide binding]; other site 945711006142 putative anticodon binding site; other site 945711006143 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945711006144 motif 1; other site 945711006145 dimer interface [polypeptide binding]; other site 945711006146 active site 945711006147 motif 2; other site 945711006148 motif 3; other site 945711006149 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 945711006150 Protein of unknown function (DUF998); Region: DUF998; pfam06197 945711006151 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 945711006152 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 945711006153 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 945711006154 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 945711006155 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 945711006156 trimer interface [polypeptide binding]; other site 945711006157 active site 945711006158 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 945711006159 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 945711006160 NAD(P) binding site [chemical binding]; other site 945711006161 catalytic residues [active] 945711006162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711006163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711006164 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945711006165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945711006166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711006167 Walker A/P-loop; other site 945711006168 ATP binding site [chemical binding]; other site 945711006169 Q-loop/lid; other site 945711006170 ABC transporter signature motif; other site 945711006171 Walker B; other site 945711006172 D-loop; other site 945711006173 H-loop/switch region; other site 945711006174 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945711006175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945711006176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711006177 Walker A/P-loop; other site 945711006178 ATP binding site [chemical binding]; other site 945711006179 Q-loop/lid; other site 945711006180 ABC transporter signature motif; other site 945711006181 Walker B; other site 945711006182 D-loop; other site 945711006183 H-loop/switch region; other site 945711006184 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 945711006185 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 945711006186 Walker A/P-loop; other site 945711006187 ATP binding site [chemical binding]; other site 945711006188 Q-loop/lid; other site 945711006189 ABC transporter signature motif; other site 945711006190 Walker B; other site 945711006191 D-loop; other site 945711006192 H-loop/switch region; other site 945711006193 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 945711006194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711006195 Walker A/P-loop; other site 945711006196 ATP binding site [chemical binding]; other site 945711006197 Q-loop/lid; other site 945711006198 ABC transporter signature motif; other site 945711006199 Walker B; other site 945711006200 D-loop; other site 945711006201 H-loop/switch region; other site 945711006202 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 945711006203 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 945711006204 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 945711006205 VanW like protein; Region: VanW; pfam04294 945711006206 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 945711006207 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 945711006208 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 945711006209 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 945711006210 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 945711006211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945711006212 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945711006213 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945711006214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711006215 S-adenosylmethionine binding site [chemical binding]; other site 945711006216 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 945711006217 active site 945711006218 substrate-binding site [chemical binding]; other site 945711006219 metal-binding site [ion binding] 945711006220 GTP binding site [chemical binding]; other site 945711006221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945711006222 S-adenosylmethionine binding site [chemical binding]; other site 945711006223 LabA_like proteins; Region: LabA_like; cd06167 945711006224 putative metal binding site [ion binding]; other site 945711006225 MMPL family; Region: MMPL; pfam03176 945711006226 MMPL family; Region: MMPL; pfam03176 945711006227 Predicted integral membrane protein [Function unknown]; Region: COG0392 945711006228 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 945711006229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 945711006230 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 945711006231 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 945711006232 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945711006233 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 945711006234 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 945711006235 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 945711006236 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 945711006237 active site 945711006238 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 945711006239 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 945711006240 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 945711006241 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 945711006242 acyl-activating enzyme (AAE) consensus motif; other site 945711006243 active site 945711006244 Cutinase; Region: Cutinase; pfam01083 945711006245 Putative esterase; Region: Esterase; pfam00756 945711006246 S-formylglutathione hydrolase; Region: PLN02442 945711006247 LGFP repeat; Region: LGFP; pfam08310 945711006248 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 945711006249 LGFP repeat; Region: LGFP; pfam08310 945711006250 LGFP repeat; Region: LGFP; pfam08310 945711006251 Putative esterase; Region: Esterase; pfam00756 945711006252 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 945711006253 UbiA prenyltransferase family; Region: UbiA; pfam01040 945711006254 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945711006255 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 945711006256 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 945711006257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945711006258 Repair protein; Region: Repair_PSII; pfam04536 945711006259 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 945711006260 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945711006261 active site 945711006262 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 945711006263 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 945711006264 active site 945711006265 catalytic site [active] 945711006266 metal binding site [ion binding]; metal-binding site 945711006267 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 945711006268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711006269 putative substrate translocation pore; other site 945711006270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711006271 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 945711006272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945711006273 UDP-galactopyranose mutase; Region: GLF; pfam03275 945711006274 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 945711006275 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 945711006276 Walker A/P-loop; other site 945711006277 ATP binding site [chemical binding]; other site 945711006278 Q-loop/lid; other site 945711006279 ABC transporter signature motif; other site 945711006280 Walker B; other site 945711006281 D-loop; other site 945711006282 H-loop/switch region; other site 945711006283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 945711006284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945711006285 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 945711006286 putative PBP binding regions; other site 945711006287 ABC-ATPase subunit interface; other site 945711006288 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 945711006289 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 945711006290 putative binding site residues; other site 945711006291 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 945711006292 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 945711006293 amidase catalytic site [active] 945711006294 Zn binding residues [ion binding]; other site 945711006295 substrate binding site [chemical binding]; other site 945711006296 LGFP repeat; Region: LGFP; pfam08310 945711006297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711006298 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 945711006299 active site 945711006300 motif I; other site 945711006301 motif II; other site 945711006302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945711006303 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 945711006304 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 945711006305 putative acyl-acceptor binding pocket; other site 945711006306 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 945711006307 seryl-tRNA synthetase; Provisional; Region: PRK05431 945711006308 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 945711006309 dimer interface [polypeptide binding]; other site 945711006310 active site 945711006311 motif 1; other site 945711006312 motif 2; other site 945711006313 motif 3; other site 945711006314 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 945711006315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 945711006316 DNA-binding site [nucleotide binding]; DNA binding site 945711006317 UTRA domain; Region: UTRA; pfam07702 945711006318 Septum formation; Region: Septum_form; pfam13845 945711006319 Septum formation; Region: Septum_form; pfam13845 945711006320 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 945711006321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945711006322 catalytic core [active] 945711006323 prephenate dehydratase; Provisional; Region: PRK11898 945711006324 Prephenate dehydratase; Region: PDT; pfam00800 945711006325 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 945711006326 putative L-Phe binding site [chemical binding]; other site 945711006327 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 945711006328 Amidase; Region: Amidase; cl11426 945711006329 CAAX protease self-immunity; Region: Abi; pfam02517 945711006330 Transcriptional regulator [Transcription]; Region: LytR; COG1316 945711006331 Htaa; Region: HtaA; pfam04213 945711006332 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 945711006333 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 945711006334 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 945711006335 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 945711006336 putative active site [active] 945711006337 catalytic site [active] 945711006338 putative metal binding site [ion binding]; other site 945711006339 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 945711006340 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 945711006341 Nucleoside recognition; Region: Gate; pfam07670 945711006342 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 945711006343 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 945711006344 active site 945711006345 catalytic motif [active] 945711006346 Zn binding site [ion binding]; other site 945711006347 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 945711006348 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 945711006349 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 945711006350 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 945711006351 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 945711006352 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 945711006353 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945711006354 NAD binding site [chemical binding]; other site 945711006355 dimer interface [polypeptide binding]; other site 945711006356 substrate binding site [chemical binding]; other site 945711006357 methionine sulfoxide reductase A; Provisional; Region: PRK00058 945711006358 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 945711006359 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 945711006360 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 945711006361 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 945711006362 Predicted flavoprotein [General function prediction only]; Region: COG0431 945711006363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 945711006364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 945711006365 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 945711006366 putative dimerization interface [polypeptide binding]; other site 945711006367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711006368 putative substrate translocation pore; other site 945711006369 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 945711006370 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 945711006371 GIY-YIG motif/motif A; other site 945711006372 putative active site [active] 945711006373 putative metal binding site [ion binding]; other site 945711006374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 945711006375 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 945711006376 Uncharacterized conserved protein [Function unknown]; Region: COG3410 945711006377 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 945711006378 homodimer interface [polypeptide binding]; other site 945711006379 chemical substrate binding site [chemical binding]; other site 945711006380 oligomer interface [polypeptide binding]; other site 945711006381 metal binding site [ion binding]; metal-binding site 945711006382 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 945711006383 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 945711006384 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 945711006385 Lsr2; Region: Lsr2; pfam11774 945711006386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711006387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711006388 active site 945711006389 phosphorylation site [posttranslational modification] 945711006390 intermolecular recognition site; other site 945711006391 dimerization interface [polypeptide binding]; other site 945711006392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711006393 DNA binding residues [nucleotide binding] 945711006394 dimerization interface [polypeptide binding]; other site 945711006395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945711006396 Histidine kinase; Region: HisKA_3; pfam07730 945711006397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711006398 ATP binding site [chemical binding]; other site 945711006399 Mg2+ binding site [ion binding]; other site 945711006400 G-X-G motif; other site 945711006401 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 945711006402 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 945711006403 active site 945711006404 catalytic site [active] 945711006405 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 945711006406 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 945711006407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711006408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711006409 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 945711006410 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711006411 Ligand Binding Site [chemical binding]; other site 945711006412 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711006413 Ligand Binding Site [chemical binding]; other site 945711006414 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 945711006415 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 945711006416 active site 945711006417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945711006418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945711006419 Walker A/P-loop; other site 945711006420 ATP binding site [chemical binding]; other site 945711006421 Q-loop/lid; other site 945711006422 ABC transporter signature motif; other site 945711006423 Walker B; other site 945711006424 D-loop; other site 945711006425 H-loop/switch region; other site 945711006426 Predicted transcriptional regulators [Transcription]; Region: COG1725 945711006427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 945711006428 DNA-binding site [nucleotide binding]; DNA binding site 945711006429 LabA_like proteins; Region: LabA_like; cd06167 945711006430 putative metal binding site [ion binding]; other site 945711006431 Uncharacterized conserved protein [Function unknown]; Region: COG1432 945711006432 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 945711006433 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945711006434 catalytic residues [active] 945711006435 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 945711006436 metal-binding site [ion binding] 945711006437 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 945711006438 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 945711006439 metal-binding site [ion binding] 945711006440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945711006441 benzoate transport; Region: 2A0115; TIGR00895 945711006442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711006443 putative substrate translocation pore; other site 945711006444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945711006445 replicative DNA helicase; Provisional; Region: PRK05636 945711006446 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 945711006447 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 945711006448 Walker A motif; other site 945711006449 ATP binding site [chemical binding]; other site 945711006450 Walker B motif; other site 945711006451 DNA binding loops [nucleotide binding] 945711006452 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 945711006453 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 945711006454 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 945711006455 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 945711006456 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 945711006457 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 945711006458 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 945711006459 dimer interface [polypeptide binding]; other site 945711006460 ssDNA binding site [nucleotide binding]; other site 945711006461 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945711006462 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 945711006463 Predicted integral membrane protein [Function unknown]; Region: COG5650 945711006464 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 945711006465 Transglycosylase; Region: Transgly; pfam00912 945711006466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 945711006467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945711006468 MarR family; Region: MarR; pfam01047 945711006469 MarR family; Region: MarR_2; cl17246 945711006470 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711006471 Ligand Binding Site [chemical binding]; other site 945711006472 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711006473 Ligand Binding Site [chemical binding]; other site 945711006474 short chain dehydrogenase; Provisional; Region: PRK08219 945711006475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945711006476 NAD(P) binding site [chemical binding]; other site 945711006477 active site 945711006478 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 945711006479 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 945711006480 active site residue [active] 945711006481 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 945711006482 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 945711006483 Htaa; Region: HtaA; pfam04213 945711006484 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 945711006485 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 945711006486 dimerization interface [polypeptide binding]; other site 945711006487 DPS ferroxidase diiron center [ion binding]; other site 945711006488 ion pore; other site 945711006489 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 945711006490 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 945711006491 putative DNA binding site [nucleotide binding]; other site 945711006492 catalytic residue [active] 945711006493 putative H2TH interface [polypeptide binding]; other site 945711006494 putative catalytic residues [active] 945711006495 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 945711006496 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 945711006497 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 945711006498 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 945711006499 putative substrate binding site [chemical binding]; other site 945711006500 putative ATP binding site [chemical binding]; other site 945711006501 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 945711006502 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 945711006503 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 945711006504 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 945711006505 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 945711006506 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 945711006507 HIGH motif; other site 945711006508 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 945711006509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711006510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945711006511 active site 945711006512 KMSKS motif; other site 945711006513 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 945711006514 tRNA binding surface [nucleotide binding]; other site 945711006515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945711006516 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945711006517 Walker A/P-loop; other site 945711006518 ATP binding site [chemical binding]; other site 945711006519 Q-loop/lid; other site 945711006520 ABC transporter signature motif; other site 945711006521 Walker B; other site 945711006522 D-loop; other site 945711006523 H-loop/switch region; other site 945711006524 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945711006525 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 945711006526 FtsX-like permease family; Region: FtsX; pfam02687 945711006527 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711006528 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711006529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945711006530 Histidine kinase; Region: HisKA_3; pfam07730 945711006531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945711006532 ATP binding site [chemical binding]; other site 945711006533 Mg2+ binding site [ion binding]; other site 945711006534 G-X-G motif; other site 945711006535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945711006536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945711006537 active site 945711006538 phosphorylation site [posttranslational modification] 945711006539 intermolecular recognition site; other site 945711006540 dimerization interface [polypeptide binding]; other site 945711006541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945711006542 DNA binding residues [nucleotide binding] 945711006543 dimerization interface [polypeptide binding]; other site 945711006544 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 945711006545 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711006546 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 945711006547 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711006548 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 945711006549 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 945711006550 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 945711006551 active site 945711006552 trimer interface [polypeptide binding]; other site 945711006553 allosteric site; other site 945711006554 active site lid [active] 945711006555 hexamer (dimer of trimers) interface [polypeptide binding]; other site 945711006556 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 945711006557 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 945711006558 active site 945711006559 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 945711006560 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 945711006561 putative active site cavity [active] 945711006562 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 945711006563 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945711006564 nucleotide binding site [chemical binding]; other site 945711006565 Transcriptional regulators [Transcription]; Region: FadR; COG2186 945711006566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 945711006567 DNA-binding site [nucleotide binding]; DNA binding site 945711006568 FCD domain; Region: FCD; pfam07729 945711006569 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 945711006570 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 945711006571 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945711006572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711006573 dimer interface [polypeptide binding]; other site 945711006574 conserved gate region; other site 945711006575 putative PBP binding loops; other site 945711006576 ABC-ATPase subunit interface; other site 945711006577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945711006578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945711006579 dimer interface [polypeptide binding]; other site 945711006580 conserved gate region; other site 945711006581 putative PBP binding loops; other site 945711006582 ABC-ATPase subunit interface; other site 945711006583 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 945711006584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711006585 Walker A/P-loop; other site 945711006586 ATP binding site [chemical binding]; other site 945711006587 Q-loop/lid; other site 945711006588 ABC transporter signature motif; other site 945711006589 Walker B; other site 945711006590 D-loop; other site 945711006591 H-loop/switch region; other site 945711006592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 945711006593 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 945711006594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945711006595 Walker A/P-loop; other site 945711006596 ATP binding site [chemical binding]; other site 945711006597 Q-loop/lid; other site 945711006598 ABC transporter signature motif; other site 945711006599 Walker B; other site 945711006600 D-loop; other site 945711006601 H-loop/switch region; other site 945711006602 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945711006603 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 945711006604 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 945711006605 inhibitor site; inhibition site 945711006606 active site 945711006607 dimer interface [polypeptide binding]; other site 945711006608 catalytic residue [active] 945711006609 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 945711006610 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 945711006611 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 945711006612 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 945711006613 tetramerization interface [polypeptide binding]; other site 945711006614 NAD(P) binding site [chemical binding]; other site 945711006615 catalytic residues [active] 945711006616 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 945711006617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945711006618 inhibitor-cofactor binding pocket; inhibition site 945711006619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711006620 catalytic residue [active] 945711006621 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 945711006622 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 945711006623 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 945711006624 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 945711006625 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 945711006626 NAD(P) binding site [chemical binding]; other site 945711006627 catalytic residues [active] 945711006628 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 945711006629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711006630 Ligand Binding Site [chemical binding]; other site 945711006631 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945711006632 Ligand Binding Site [chemical binding]; other site 945711006633 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 945711006634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945711006635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945711006636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945711006637 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 945711006638 active site 945711006639 catalytic residues [active] 945711006640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 945711006641 hypothetical protein; Provisional; Region: PRK13663 945711006642 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 945711006643 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 945711006644 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 945711006645 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 945711006646 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 945711006647 active site lid residues [active] 945711006648 substrate binding pocket [chemical binding]; other site 945711006649 catalytic residues [active] 945711006650 substrate-Mg2+ binding site; other site 945711006651 aspartate-rich region 1; other site 945711006652 aspartate-rich region 2; other site 945711006653 phytoene desaturase; Region: crtI_fam; TIGR02734 945711006654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945711006655 SdpI/YhfL protein family; Region: SdpI; pfam13630 945711006656 anthranilate synthase component I; Provisional; Region: PRK13564 945711006657 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 945711006658 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 945711006659 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 945711006660 Glutamine amidotransferase class-I; Region: GATase; pfam00117 945711006661 glutamine binding [chemical binding]; other site 945711006662 catalytic triad [active] 945711006663 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 945711006664 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 945711006665 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 945711006666 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 945711006667 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 945711006668 active site 945711006669 ribulose/triose binding site [chemical binding]; other site 945711006670 phosphate binding site [ion binding]; other site 945711006671 substrate (anthranilate) binding pocket [chemical binding]; other site 945711006672 product (indole) binding pocket [chemical binding]; other site 945711006673 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 945711006674 active site 945711006675 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 945711006676 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 945711006677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945711006678 catalytic residue [active] 945711006679 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 945711006680 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 945711006681 substrate binding site [chemical binding]; other site 945711006682 active site 945711006683 catalytic residues [active] 945711006684 heterodimer interface [polypeptide binding]; other site 945711006685 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 945711006686 iron-sulfur cluster [ion binding]; other site 945711006687 [2Fe-2S] cluster binding site [ion binding]; other site 945711006688 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 945711006689 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 945711006690 diaminohydroxyphosphoribosylaminopyrimidine deaminase; Region: PLN02807 945711006691 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 945711006692 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 945711006693 hypothetical protein; Validated; Region: PRK00228 945711006694 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 945711006695 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 945711006696 active site 945711006697 NTP binding site [chemical binding]; other site 945711006698 metal binding triad [ion binding]; metal-binding site 945711006699 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 945711006700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945711006701 Zn2+ binding site [ion binding]; other site 945711006702 Mg2+ binding site [ion binding]; other site 945711006703 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 945711006704 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 945711006705 active site 945711006706 Ap6A binding site [chemical binding]; other site 945711006707 nudix motif; other site 945711006708 metal binding site [ion binding]; metal-binding site 945711006709 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 945711006710 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 945711006711 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 945711006712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945711006713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945711006714 DNA binding residues [nucleotide binding] 945711006715 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 945711006716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945711006717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945711006718 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945711006719 catalytic residues [active] 945711006720 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 945711006721 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 945711006722 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 945711006723 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 945711006724 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 945711006725 active site 945711006726 metal binding site [ion binding]; metal-binding site 945711006727 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 945711006728 ParB-like nuclease domain; Region: ParBc; pfam02195 945711006729 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 945711006730 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 945711006731 P-loop; other site 945711006732 Magnesium ion binding site [ion binding]; other site 945711006733 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 945711006734 Magnesium ion binding site [ion binding]; other site 945711006735 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 945711006736 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 945711006737 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 945711006738 Haemolytic domain; Region: Haemolytic; pfam01809 945711006739 ribonuclease P; Reviewed; Region: rnpA; PRK03459 945711006740 Ribosomal protein L34; Region: Ribosomal_L34; cl00370