-- dump date 20140619_053121 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1267754000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1267754000003 Walker A motif; other site 1267754000004 ATP binding site [chemical binding]; other site 1267754000005 Walker B motif; other site 1267754000006 arginine finger; other site 1267754000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1267754000008 DnaA box-binding interface [nucleotide binding]; other site 1267754000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1267754000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1267754000011 putative DNA binding surface [nucleotide binding]; other site 1267754000012 dimer interface [polypeptide binding]; other site 1267754000013 beta-clamp/clamp loader binding surface; other site 1267754000014 beta-clamp/translesion DNA polymerase binding surface; other site 1267754000015 recombination protein F; Reviewed; Region: recF; PRK00064 1267754000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1267754000017 Walker A/P-loop; other site 1267754000018 ATP binding site [chemical binding]; other site 1267754000019 Q-loop/lid; other site 1267754000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754000021 ABC transporter signature motif; other site 1267754000022 Walker B; other site 1267754000023 D-loop; other site 1267754000024 H-loop/switch region; other site 1267754000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1267754000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1267754000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754000028 Mg2+ binding site [ion binding]; other site 1267754000029 G-X-G motif; other site 1267754000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1267754000031 anchoring element; other site 1267754000032 dimer interface [polypeptide binding]; other site 1267754000033 ATP binding site [chemical binding]; other site 1267754000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1267754000035 active site 1267754000036 putative metal-binding site [ion binding]; other site 1267754000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1267754000038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1267754000039 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1267754000040 beta-galactosidase; Region: BGL; TIGR03356 1267754000041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754000043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754000045 DNA gyrase subunit A; Validated; Region: PRK05560 1267754000046 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1267754000047 CAP-like domain; other site 1267754000048 active site 1267754000049 primary dimer interface [polypeptide binding]; other site 1267754000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1267754000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1267754000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1267754000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1267754000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1267754000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1267754000056 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1267754000057 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1267754000058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1267754000059 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1267754000060 active site 1267754000061 Int/Topo IB signature motif; other site 1267754000062 catalytic residues [active] 1267754000063 DNA binding site [nucleotide binding] 1267754000064 AAA domain; Region: AAA_25; pfam13481 1267754000065 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1267754000066 Protein of unknown function (DUF390); Region: DUF390; pfam04094 1267754000067 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1267754000068 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1267754000069 Abortive infection C-terminus; Region: Abi_C; pfam14355 1267754000070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754000071 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1267754000072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000073 putative substrate translocation pore; other site 1267754000074 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1267754000075 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1267754000076 catalytic residues [active] 1267754000077 catalytic nucleophile [active] 1267754000078 Presynaptic Site I dimer interface [polypeptide binding]; other site 1267754000079 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1267754000080 Synaptic Flat tetramer interface [polypeptide binding]; other site 1267754000081 Synaptic Site I dimer interface [polypeptide binding]; other site 1267754000082 DNA binding site [nucleotide binding] 1267754000083 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1267754000084 DNA-binding interface [nucleotide binding]; DNA binding site 1267754000085 AAA domain; Region: AAA_14; pfam13173 1267754000086 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1267754000087 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1267754000088 active site 1267754000089 catalytic site [active] 1267754000090 substrate binding site [chemical binding]; other site 1267754000091 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1267754000092 short chain dehydrogenase; Provisional; Region: PRK08267 1267754000093 classical (c) SDRs; Region: SDR_c; cd05233 1267754000094 NAD(P) binding site [chemical binding]; other site 1267754000095 active site 1267754000096 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1267754000097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1267754000098 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1267754000099 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1267754000100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1267754000101 putative Zn2+ binding site [ion binding]; other site 1267754000102 putative DNA binding site [nucleotide binding]; other site 1267754000103 dimerization interface [polypeptide binding]; other site 1267754000104 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1267754000105 arsenical-resistance protein; Region: acr3; TIGR00832 1267754000106 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1267754000107 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1267754000108 active site 1267754000109 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1267754000110 Abi-like protein; Region: Abi_2; pfam07751 1267754000111 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1267754000112 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1267754000113 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1267754000114 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1267754000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000116 putative substrate translocation pore; other site 1267754000117 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1267754000118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754000119 catalytic residue [active] 1267754000120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1267754000121 dimerization interface [polypeptide binding]; other site 1267754000122 putative DNA binding site [nucleotide binding]; other site 1267754000123 putative Zn2+ binding site [ion binding]; other site 1267754000124 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1267754000125 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1267754000126 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1267754000127 active site 1267754000128 Rhomboid family; Region: Rhomboid; cl11446 1267754000129 putative septation inhibitor protein; Reviewed; Region: PRK00159 1267754000130 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1267754000131 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1267754000132 glutamine binding [chemical binding]; other site 1267754000133 catalytic triad [active] 1267754000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1267754000135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1267754000136 active site 1267754000137 ATP binding site [chemical binding]; other site 1267754000138 substrate binding site [chemical binding]; other site 1267754000139 activation loop (A-loop); other site 1267754000140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1267754000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754000144 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1267754000146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1267754000147 active site 1267754000148 ATP binding site [chemical binding]; other site 1267754000149 substrate binding site [chemical binding]; other site 1267754000150 activation loop (A-loop); other site 1267754000151 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1267754000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1267754000153 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1267754000154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1267754000155 Protein phosphatase 2C; Region: PP2C; pfam00481 1267754000156 active site 1267754000157 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1267754000158 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1267754000159 phosphopeptide binding site; other site 1267754000160 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1267754000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1267754000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1267754000163 phosphopeptide binding site; other site 1267754000164 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1267754000165 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1267754000166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754000167 ATP binding site [chemical binding]; other site 1267754000168 Q-loop/lid; other site 1267754000169 ABC transporter signature motif; other site 1267754000170 Walker B; other site 1267754000171 D-loop; other site 1267754000172 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1267754000173 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1267754000174 Q-loop/lid; other site 1267754000175 ABC transporter signature motif; other site 1267754000176 Walker B; other site 1267754000177 D-loop; other site 1267754000178 H-loop/switch region; other site 1267754000179 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1267754000180 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1267754000181 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1267754000182 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1267754000183 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1267754000184 CoenzymeA binding site [chemical binding]; other site 1267754000185 subunit interaction site [polypeptide binding]; other site 1267754000186 PHB binding site; other site 1267754000187 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1267754000188 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1267754000189 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1267754000190 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1267754000191 active site 1267754000192 homotetramer interface [polypeptide binding]; other site 1267754000193 homodimer interface [polypeptide binding]; other site 1267754000194 CAAX protease self-immunity; Region: Abi; cl00558 1267754000195 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1267754000196 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1267754000197 quinolinate synthetase; Provisional; Region: PRK09375 1267754000198 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1267754000199 L-aspartate oxidase; Provisional; Region: PRK06175 1267754000200 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1267754000201 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1267754000202 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1267754000203 dimerization interface [polypeptide binding]; other site 1267754000204 active site 1267754000205 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1267754000206 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1267754000207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754000208 catalytic residue [active] 1267754000209 benzoate transport; Region: 2A0115; TIGR00895 1267754000210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000211 putative substrate translocation pore; other site 1267754000212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000213 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1267754000214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754000215 NAD(P) binding site [chemical binding]; other site 1267754000216 active site 1267754000217 Fic family protein [Function unknown]; Region: COG3177 1267754000218 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1267754000219 Fic/DOC family; Region: Fic; pfam02661 1267754000220 NAD-dependent deacetylase; Provisional; Region: PRK00481 1267754000221 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1267754000222 NAD+ binding site [chemical binding]; other site 1267754000223 substrate binding site [chemical binding]; other site 1267754000224 Zn binding site [ion binding]; other site 1267754000225 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1267754000226 active site 1267754000227 8-oxo-dGMP binding site [chemical binding]; other site 1267754000228 nudix motif; other site 1267754000229 metal binding site [ion binding]; metal-binding site 1267754000230 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1267754000231 PLD-like domain; Region: PLDc_2; pfam13091 1267754000232 putative homodimer interface [polypeptide binding]; other site 1267754000233 putative active site [active] 1267754000234 catalytic site [active] 1267754000235 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1267754000236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754000237 ATP binding site [chemical binding]; other site 1267754000238 putative Mg++ binding site [ion binding]; other site 1267754000239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754000240 nucleotide binding region [chemical binding]; other site 1267754000241 ATP-binding site [chemical binding]; other site 1267754000242 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1267754000243 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1267754000244 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1267754000245 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1267754000246 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1267754000247 trimer interface [polypeptide binding]; other site 1267754000248 putative metal binding site [ion binding]; other site 1267754000249 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1267754000250 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1267754000251 Protein of unknown function, DUF488; Region: DUF488; cl01246 1267754000252 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 1267754000253 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1267754000254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754000255 active site 1267754000256 phosphorylation site [posttranslational modification] 1267754000257 intermolecular recognition site; other site 1267754000258 dimerization interface [polypeptide binding]; other site 1267754000259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1267754000260 DNA binding residues [nucleotide binding] 1267754000261 dimerization interface [polypeptide binding]; other site 1267754000262 PspC domain; Region: PspC; pfam04024 1267754000263 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1267754000264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754000265 ATP binding site [chemical binding]; other site 1267754000266 Mg2+ binding site [ion binding]; other site 1267754000267 G-X-G motif; other site 1267754000268 PspC domain; Region: PspC; pfam04024 1267754000269 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1267754000270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754000271 ATP binding site [chemical binding]; other site 1267754000272 putative Mg++ binding site [ion binding]; other site 1267754000273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754000274 nucleotide binding region [chemical binding]; other site 1267754000275 ATP-binding site [chemical binding]; other site 1267754000276 Helicase associated domain (HA2); Region: HA2; pfam04408 1267754000277 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1267754000278 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1267754000279 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1267754000280 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1267754000281 active site 1267754000282 FMN binding site [chemical binding]; other site 1267754000283 2,4-decadienoyl-CoA binding site; other site 1267754000284 catalytic residue [active] 1267754000285 4Fe-4S cluster binding site [ion binding]; other site 1267754000286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1267754000287 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1267754000288 RNA binding surface [nucleotide binding]; other site 1267754000289 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1267754000290 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1267754000291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1267754000292 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1267754000293 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1267754000294 active site 1267754000295 Zn binding site [ion binding]; other site 1267754000296 Protease prsW family; Region: PrsW-protease; pfam13367 1267754000297 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1267754000298 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1267754000299 active site 1267754000300 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1267754000301 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1267754000302 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1267754000303 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1267754000304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1267754000305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754000306 active site 1267754000307 phosphorylation site [posttranslational modification] 1267754000308 intermolecular recognition site; other site 1267754000309 dimerization interface [polypeptide binding]; other site 1267754000310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1267754000311 DNA binding site [nucleotide binding] 1267754000312 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1267754000313 metal-binding site [ion binding] 1267754000314 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1267754000315 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1267754000316 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1267754000317 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1267754000318 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1267754000319 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1267754000320 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1267754000321 LabA_like proteins; Region: LabA_like; cd06167 1267754000322 putative metal binding site [ion binding]; other site 1267754000323 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1267754000324 Predicted transcriptional regulators [Transcription]; Region: COG1725 1267754000325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1267754000326 DNA-binding site [nucleotide binding]; DNA binding site 1267754000327 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1267754000328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000329 putative substrate translocation pore; other site 1267754000330 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1267754000331 active site 1267754000332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1267754000333 Ligand Binding Site [chemical binding]; other site 1267754000334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1267754000335 Ligand Binding Site [chemical binding]; other site 1267754000336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754000337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754000338 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1267754000339 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1267754000340 active site 1267754000341 catalytic site [active] 1267754000342 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1267754000343 Lsr2; Region: Lsr2; pfam11774 1267754000344 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1267754000345 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1267754000346 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1267754000347 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1267754000348 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1267754000349 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1267754000350 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1267754000351 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1267754000352 active site 1267754000353 nucleophile elbow; other site 1267754000354 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1267754000355 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1267754000356 active site 1267754000357 catalytic site [active] 1267754000358 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1267754000359 Predicted flavoprotein [General function prediction only]; Region: COG0431 1267754000360 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1267754000361 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1267754000362 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1267754000363 dimer interface [polypeptide binding]; other site 1267754000364 putative radical transfer pathway; other site 1267754000365 diiron center [ion binding]; other site 1267754000366 tyrosyl radical; other site 1267754000367 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1267754000368 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1267754000369 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1267754000370 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1267754000371 FeoA domain; Region: FeoA; pfam04023 1267754000372 CAAX protease self-immunity; Region: Abi; pfam02517 1267754000373 Amidase; Region: Amidase; cl11426 1267754000374 prephenate dehydratase; Provisional; Region: PRK11898 1267754000375 Prephenate dehydratase; Region: PDT; pfam00800 1267754000376 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1267754000377 putative L-Phe binding site [chemical binding]; other site 1267754000378 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754000379 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1267754000380 Septum formation; Region: Septum_form; pfam13845 1267754000381 Septum formation; Region: Septum_form; pfam13845 1267754000382 seryl-tRNA synthetase; Provisional; Region: PRK05431 1267754000383 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1267754000384 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1267754000385 dimer interface [polypeptide binding]; other site 1267754000386 active site 1267754000387 motif 1; other site 1267754000388 motif 2; other site 1267754000389 motif 3; other site 1267754000390 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1267754000391 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1267754000392 putative acyl-acceptor binding pocket; other site 1267754000393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754000394 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1267754000395 active site 1267754000396 motif I; other site 1267754000397 motif II; other site 1267754000398 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1267754000399 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1267754000400 FAD binding domain; Region: FAD_binding_4; pfam01565 1267754000401 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1267754000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754000403 S-adenosylmethionine binding site [chemical binding]; other site 1267754000404 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1267754000405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1267754000406 UDP-galactopyranose mutase; Region: GLF; pfam03275 1267754000407 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1267754000408 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1267754000409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754000410 ATP binding site [chemical binding]; other site 1267754000411 putative Mg++ binding site [ion binding]; other site 1267754000412 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1267754000413 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1267754000414 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1267754000415 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1267754000416 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1267754000417 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1267754000418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754000419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754000420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1267754000421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1267754000422 Walker A/P-loop; other site 1267754000423 ATP binding site [chemical binding]; other site 1267754000424 Q-loop/lid; other site 1267754000425 ABC transporter signature motif; other site 1267754000426 Walker B; other site 1267754000427 D-loop; other site 1267754000428 H-loop/switch region; other site 1267754000429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1267754000430 FtsX-like permease family; Region: FtsX; pfam02687 1267754000431 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1267754000432 active site 1267754000433 catalytic triad [active] 1267754000434 oxyanion hole [active] 1267754000435 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1267754000436 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1267754000437 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1267754000438 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1267754000439 active site 1267754000440 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1267754000441 UbiA prenyltransferase family; Region: UbiA; pfam01040 1267754000442 Putative esterase; Region: Esterase; pfam00756 1267754000443 S-formylglutathione hydrolase; Region: PLN02442 1267754000444 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1267754000445 LGFP repeat; Region: LGFP; pfam08310 1267754000446 LGFP repeat; Region: LGFP; pfam08310 1267754000447 LGFP repeat; Region: LGFP; pfam08310 1267754000448 LGFP repeat; Region: LGFP; pfam08310 1267754000449 Cutinase; Region: Cutinase; pfam01083 1267754000450 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1267754000451 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1267754000452 acyl-activating enzyme (AAE) consensus motif; other site 1267754000453 active site 1267754000454 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1267754000455 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1267754000456 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1267754000457 active site 1267754000458 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1267754000459 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1267754000460 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1267754000461 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1267754000462 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1267754000463 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1267754000464 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1267754000465 acyl-CoA synthetase; Validated; Region: PRK07788 1267754000466 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754000467 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1267754000468 acyl-activating enzyme (AAE) consensus motif; other site 1267754000469 acyl-activating enzyme (AAE) consensus motif; other site 1267754000470 AMP binding site [chemical binding]; other site 1267754000471 active site 1267754000472 CoA binding site [chemical binding]; other site 1267754000473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754000475 putative substrate translocation pore; other site 1267754000476 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 1267754000477 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1267754000478 Predicted integral membrane protein [Function unknown]; Region: COG0392 1267754000479 MMPL family; Region: MMPL; pfam03176 1267754000480 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1267754000481 MMPL family; Region: MMPL; pfam03176 1267754000482 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1267754000483 LabA_like proteins; Region: LabA_like; cd06167 1267754000484 putative metal binding site [ion binding]; other site 1267754000485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754000486 S-adenosylmethionine binding site [chemical binding]; other site 1267754000487 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1267754000488 active site 1267754000489 substrate-binding site [chemical binding]; other site 1267754000490 metal-binding site [ion binding] 1267754000491 GTP binding site [chemical binding]; other site 1267754000492 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1267754000493 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1267754000494 catalytic residue [active] 1267754000495 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1267754000496 catalytic residues [active] 1267754000497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1267754000498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1267754000499 peroxiredoxin; Region: AhpC; TIGR03137 1267754000500 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1267754000501 dimer interface [polypeptide binding]; other site 1267754000502 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1267754000503 catalytic triad [active] 1267754000504 peroxidatic and resolving cysteines [active] 1267754000505 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1267754000506 Sulphur transport; Region: Sulf_transp; pfam04143 1267754000507 Sulphur transport; Region: Sulf_transp; pfam04143 1267754000508 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1267754000509 CPxP motif; other site 1267754000510 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1267754000511 metal ion-dependent adhesion site (MIDAS); other site 1267754000512 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1267754000513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754000514 substrate binding site [chemical binding]; other site 1267754000515 oxyanion hole (OAH) forming residues; other site 1267754000516 trimer interface [polypeptide binding]; other site 1267754000517 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1267754000518 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1267754000519 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1267754000520 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1267754000521 dimer interface [polypeptide binding]; other site 1267754000522 active site 1267754000523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754000524 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1267754000525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1267754000526 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1267754000527 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1267754000528 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1267754000529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1267754000530 Ligand Binding Site [chemical binding]; other site 1267754000531 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1267754000532 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1267754000533 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1267754000534 VanW like protein; Region: VanW; pfam04294 1267754000535 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1267754000536 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1267754000537 isocitrate lyase; Provisional; Region: PRK15063 1267754000538 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1267754000539 tetramer interface [polypeptide binding]; other site 1267754000540 active site 1267754000541 Mg2+/Mn2+ binding site [ion binding]; other site 1267754000542 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1267754000543 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1267754000544 CGNR zinc finger; Region: zf-CGNR; pfam11706 1267754000545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000547 putative substrate translocation pore; other site 1267754000548 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754000549 malate synthase G; Provisional; Region: PRK02999 1267754000550 active site 1267754000551 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1267754000552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754000553 motif II; other site 1267754000554 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1267754000555 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1267754000556 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1267754000557 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1267754000558 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1267754000559 putative Iron-sulfur protein interface [polypeptide binding]; other site 1267754000560 proximal heme binding site [chemical binding]; other site 1267754000561 distal heme binding site [chemical binding]; other site 1267754000562 putative dimer interface [polypeptide binding]; other site 1267754000563 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1267754000564 L-aspartate oxidase; Provisional; Region: PRK06175 1267754000565 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1267754000566 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1267754000567 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1267754000568 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1267754000569 Predicted membrane protein [Function unknown]; Region: COG2733 1267754000570 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1267754000571 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1267754000572 intersubunit interface [polypeptide binding]; other site 1267754000573 active site 1267754000574 catalytic residue [active] 1267754000575 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1267754000576 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1267754000577 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1267754000578 FAD binding domain; Region: FAD_binding_4; pfam01565 1267754000579 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1267754000580 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1267754000581 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754000582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754000583 acyl-activating enzyme (AAE) consensus motif; other site 1267754000584 AMP binding site [chemical binding]; other site 1267754000585 active site 1267754000586 CoA binding site [chemical binding]; other site 1267754000587 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1267754000588 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1267754000589 putative ADP-binding pocket [chemical binding]; other site 1267754000590 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1267754000591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754000592 catalytic core [active] 1267754000593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754000594 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1267754000595 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1267754000596 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1267754000597 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1267754000598 DNA binding domain, excisionase family; Region: excise; TIGR01764 1267754000599 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1267754000600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754000601 motif II; other site 1267754000602 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1267754000603 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1267754000604 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1267754000605 tRNA; other site 1267754000606 putative tRNA binding site [nucleotide binding]; other site 1267754000607 putative NADP binding site [chemical binding]; other site 1267754000608 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1267754000609 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1267754000610 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1267754000611 domain interfaces; other site 1267754000612 active site 1267754000613 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1267754000614 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1267754000615 active site 1267754000616 SAM binding site [chemical binding]; other site 1267754000617 homodimer interface [polypeptide binding]; other site 1267754000618 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1267754000619 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1267754000620 active site 1267754000621 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1267754000622 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1267754000623 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1267754000624 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1267754000625 dimer interface [polypeptide binding]; other site 1267754000626 active site 1267754000627 Schiff base residues; other site 1267754000628 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1267754000629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1267754000630 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1267754000631 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1267754000632 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1267754000633 inhibitor-cofactor binding pocket; inhibition site 1267754000634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754000635 catalytic residue [active] 1267754000636 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754000637 catalytic core [active] 1267754000638 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1267754000639 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1267754000640 catalytic residues [active] 1267754000641 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1267754000642 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1267754000643 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1267754000644 ResB-like family; Region: ResB; pfam05140 1267754000645 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1267754000646 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1267754000647 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1267754000648 NAD binding site [chemical binding]; other site 1267754000649 substrate binding site [chemical binding]; other site 1267754000650 homodimer interface [polypeptide binding]; other site 1267754000651 active site 1267754000652 metabolite-proton symporter; Region: 2A0106; TIGR00883 1267754000653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000654 putative substrate translocation pore; other site 1267754000655 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1267754000656 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1267754000657 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1267754000658 substrate binding site; other site 1267754000659 tetramer interface; other site 1267754000660 Phosphotransferase enzyme family; Region: APH; pfam01636 1267754000661 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1267754000662 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1267754000663 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1267754000664 UbiA prenyltransferase family; Region: UbiA; pfam01040 1267754000665 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1267754000666 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1267754000667 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1267754000668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1267754000669 Walker A/P-loop; other site 1267754000670 ATP binding site [chemical binding]; other site 1267754000671 Q-loop/lid; other site 1267754000672 ABC transporter signature motif; other site 1267754000673 Walker B; other site 1267754000674 D-loop; other site 1267754000675 H-loop/switch region; other site 1267754000676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1267754000677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1267754000678 Walker A/P-loop; other site 1267754000679 ATP binding site [chemical binding]; other site 1267754000680 Q-loop/lid; other site 1267754000681 ABC transporter signature motif; other site 1267754000682 Walker B; other site 1267754000683 D-loop; other site 1267754000684 H-loop/switch region; other site 1267754000685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1267754000686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1267754000687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754000688 dimer interface [polypeptide binding]; other site 1267754000689 conserved gate region; other site 1267754000690 putative PBP binding loops; other site 1267754000691 ABC-ATPase subunit interface; other site 1267754000692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1267754000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1267754000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754000695 dimer interface [polypeptide binding]; other site 1267754000696 conserved gate region; other site 1267754000697 putative PBP binding loops; other site 1267754000698 ABC-ATPase subunit interface; other site 1267754000699 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1267754000700 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1267754000701 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1267754000702 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1267754000703 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1267754000704 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754000705 acyl-activating enzyme (AAE) consensus motif; other site 1267754000706 AMP binding site [chemical binding]; other site 1267754000707 active site 1267754000708 CoA binding site [chemical binding]; other site 1267754000709 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1267754000710 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1267754000711 active site 1267754000712 naphthoate synthase; Region: PLN02921 1267754000713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754000714 substrate binding site [chemical binding]; other site 1267754000715 oxyanion hole (OAH) forming residues; other site 1267754000716 trimer interface [polypeptide binding]; other site 1267754000717 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1267754000718 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1267754000719 active site 1267754000720 Divergent AAA domain; Region: AAA_4; pfam04326 1267754000721 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1267754000722 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1267754000723 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1267754000724 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1267754000725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1267754000726 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1267754000727 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1267754000728 dimer interface [polypeptide binding]; other site 1267754000729 tetramer interface [polypeptide binding]; other site 1267754000730 PYR/PP interface [polypeptide binding]; other site 1267754000731 TPP binding site [chemical binding]; other site 1267754000732 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1267754000733 TPP-binding site; other site 1267754000734 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1267754000735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1267754000736 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1267754000737 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1267754000738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754000739 S-adenosylmethionine binding site [chemical binding]; other site 1267754000740 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1267754000741 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1267754000742 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1267754000743 substrate binding pocket [chemical binding]; other site 1267754000744 chain length determination region; other site 1267754000745 substrate-Mg2+ binding site; other site 1267754000746 catalytic residues [active] 1267754000747 aspartate-rich region 1; other site 1267754000748 active site lid residues [active] 1267754000749 aspartate-rich region 2; other site 1267754000750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754000751 MULE transposase domain; Region: MULE; pfam10551 1267754000752 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1267754000753 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1267754000754 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1267754000755 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1267754000756 proposed catalytic triad [active] 1267754000757 conserved cys residue [active] 1267754000758 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1267754000759 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1267754000760 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1267754000761 MULE transposase domain; Region: MULE; pfam10551 1267754000762 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1267754000763 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1267754000764 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1267754000765 putative homodimer interface [polypeptide binding]; other site 1267754000766 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1267754000767 heterodimer interface [polypeptide binding]; other site 1267754000768 homodimer interface [polypeptide binding]; other site 1267754000769 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1267754000770 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cl08257 1267754000771 23S rRNA interface [nucleotide binding]; other site 1267754000772 L7/L12 interface [polypeptide binding]; other site 1267754000773 putative thiostrepton binding site; other site 1267754000774 L25 interface [polypeptide binding]; other site 1267754000775 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1267754000776 mRNA/rRNA interface [nucleotide binding]; other site 1267754000777 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1267754000778 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1267754000779 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754000780 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1267754000781 intersubunit interface [polypeptide binding]; other site 1267754000782 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1267754000783 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754000784 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1267754000785 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1267754000786 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1267754000787 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1267754000788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754000789 ABC-ATPase subunit interface; other site 1267754000790 dimer interface [polypeptide binding]; other site 1267754000791 putative PBP binding regions; other site 1267754000792 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1267754000793 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1267754000794 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1267754000795 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1267754000796 23S rRNA interface [nucleotide binding]; other site 1267754000797 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1267754000798 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1267754000799 peripheral dimer interface [polypeptide binding]; other site 1267754000800 core dimer interface [polypeptide binding]; other site 1267754000801 L10 interface [polypeptide binding]; other site 1267754000802 L11 interface [polypeptide binding]; other site 1267754000803 putative EF-Tu interaction site [polypeptide binding]; other site 1267754000804 putative EF-G interaction site [polypeptide binding]; other site 1267754000805 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1267754000806 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1267754000807 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1267754000808 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1267754000809 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1267754000810 RPB1 interaction site [polypeptide binding]; other site 1267754000811 RPB10 interaction site [polypeptide binding]; other site 1267754000812 RPB11 interaction site [polypeptide binding]; other site 1267754000813 RPB3 interaction site [polypeptide binding]; other site 1267754000814 RPB12 interaction site [polypeptide binding]; other site 1267754000815 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1267754000816 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1267754000817 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1267754000818 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1267754000819 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1267754000820 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1267754000821 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1267754000822 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1267754000823 DNA binding site [nucleotide binding] 1267754000824 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1267754000825 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1267754000826 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1267754000827 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1267754000828 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1267754000829 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1267754000830 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1267754000831 effector binding site; other site 1267754000832 active site 1267754000833 Zn binding site [ion binding]; other site 1267754000834 glycine loop; other site 1267754000835 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1267754000836 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1267754000837 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1267754000838 catalytic triad [active] 1267754000839 catalytic triad [active] 1267754000840 oxyanion hole [active] 1267754000841 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1267754000842 S17 interaction site [polypeptide binding]; other site 1267754000843 S8 interaction site; other site 1267754000844 16S rRNA interaction site [nucleotide binding]; other site 1267754000845 streptomycin interaction site [chemical binding]; other site 1267754000846 23S rRNA interaction site [nucleotide binding]; other site 1267754000847 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1267754000848 30S ribosomal protein S7; Validated; Region: PRK05302 1267754000849 elongation factor G; Reviewed; Region: PRK00007 1267754000850 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1267754000851 G1 box; other site 1267754000852 putative GEF interaction site [polypeptide binding]; other site 1267754000853 GTP/Mg2+ binding site [chemical binding]; other site 1267754000854 Switch I region; other site 1267754000855 G2 box; other site 1267754000856 G3 box; other site 1267754000857 Switch II region; other site 1267754000858 G4 box; other site 1267754000859 G5 box; other site 1267754000860 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1267754000861 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1267754000862 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1267754000863 elongation factor Tu; Reviewed; Region: PRK00049 1267754000864 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1267754000865 G1 box; other site 1267754000866 GEF interaction site [polypeptide binding]; other site 1267754000867 GTP/Mg2+ binding site [chemical binding]; other site 1267754000868 Switch I region; other site 1267754000869 G2 box; other site 1267754000870 G3 box; other site 1267754000871 Switch II region; other site 1267754000872 G4 box; other site 1267754000873 G5 box; other site 1267754000874 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1267754000875 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1267754000876 Antibiotic Binding Site [chemical binding]; other site 1267754000877 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1267754000878 active site 1267754000879 catalytic site [active] 1267754000880 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1267754000881 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1267754000882 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1267754000883 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1267754000884 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1267754000885 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1267754000886 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1267754000887 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1267754000888 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1267754000889 putative translocon binding site; other site 1267754000890 protein-rRNA interface [nucleotide binding]; other site 1267754000891 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1267754000892 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1267754000893 G-X-X-G motif; other site 1267754000894 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1267754000895 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1267754000896 23S rRNA interface [nucleotide binding]; other site 1267754000897 5S rRNA interface [nucleotide binding]; other site 1267754000898 putative antibiotic binding site [chemical binding]; other site 1267754000899 L25 interface [polypeptide binding]; other site 1267754000900 L27 interface [polypeptide binding]; other site 1267754000901 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1267754000902 23S rRNA interface [nucleotide binding]; other site 1267754000903 putative translocon interaction site; other site 1267754000904 signal recognition particle (SRP54) interaction site; other site 1267754000905 L23 interface [polypeptide binding]; other site 1267754000906 trigger factor interaction site; other site 1267754000907 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1267754000908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754000910 putative substrate translocation pore; other site 1267754000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754000912 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754000913 putative substrate translocation pore; other site 1267754000914 HTH-like domain; Region: HTH_21; pfam13276 1267754000915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1267754000916 Integrase core domain; Region: rve; pfam00665 1267754000917 Integrase core domain; Region: rve_2; pfam13333 1267754000918 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1267754000919 Isochorismatase family; Region: Isochorismatase; pfam00857 1267754000920 catalytic triad [active] 1267754000921 conserved cis-peptide bond; other site 1267754000922 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1267754000923 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1267754000924 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1267754000925 acyl-activating enzyme (AAE) consensus motif; other site 1267754000926 active site 1267754000927 AMP binding site [chemical binding]; other site 1267754000928 substrate binding site [chemical binding]; other site 1267754000929 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1267754000930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754000931 NAD(P) binding site [chemical binding]; other site 1267754000932 active site 1267754000933 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754000934 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1267754000935 Walker A/P-loop; other site 1267754000936 ATP binding site [chemical binding]; other site 1267754000937 Q-loop/lid; other site 1267754000938 ABC transporter signature motif; other site 1267754000939 Walker B; other site 1267754000940 D-loop; other site 1267754000941 H-loop/switch region; other site 1267754000942 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1267754000943 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754000944 ABC-ATPase subunit interface; other site 1267754000945 dimer interface [polypeptide binding]; other site 1267754000946 putative PBP binding regions; other site 1267754000947 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1267754000948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754000949 ABC-ATPase subunit interface; other site 1267754000950 dimer interface [polypeptide binding]; other site 1267754000951 putative PBP binding regions; other site 1267754000952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1267754000953 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1267754000954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754000955 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1267754000956 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1267754000957 acyl-activating enzyme (AAE) consensus motif; other site 1267754000958 AMP binding site [chemical binding]; other site 1267754000959 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754000960 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1267754000961 intersubunit interface [polypeptide binding]; other site 1267754000962 Condensation domain; Region: Condensation; pfam00668 1267754000963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1267754000964 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1267754000965 acyl-activating enzyme (AAE) consensus motif; other site 1267754000966 AMP binding site [chemical binding]; other site 1267754000967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1267754000968 Condensation domain; Region: Condensation; pfam00668 1267754000969 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1267754000970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1267754000971 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1267754000972 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1267754000973 FAD binding pocket [chemical binding]; other site 1267754000974 FAD binding motif [chemical binding]; other site 1267754000975 phosphate binding motif [ion binding]; other site 1267754000976 NAD binding pocket [chemical binding]; other site 1267754000977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754000978 intersubunit interface [polypeptide binding]; other site 1267754000979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1267754000980 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1267754000981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754000982 dimer interface [polypeptide binding]; other site 1267754000983 putative PBP binding regions; other site 1267754000984 ABC-ATPase subunit interface; other site 1267754000985 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754000986 ABC transporter; Region: ABC_tran; pfam00005 1267754000987 Q-loop/lid; other site 1267754000988 ABC transporter signature motif; other site 1267754000989 Walker B; other site 1267754000990 D-loop; other site 1267754000991 H-loop/switch region; other site 1267754000992 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1267754000993 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1267754000994 FAD binding pocket [chemical binding]; other site 1267754000995 FAD binding motif [chemical binding]; other site 1267754000996 phosphate binding motif [ion binding]; other site 1267754000997 NAD binding pocket [chemical binding]; other site 1267754000998 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1267754000999 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1267754001000 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1267754001001 RNA binding site [nucleotide binding]; other site 1267754001002 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1267754001003 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1267754001004 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1267754001005 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1267754001006 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1267754001007 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1267754001008 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1267754001009 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1267754001010 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1267754001011 5S rRNA interface [nucleotide binding]; other site 1267754001012 L27 interface [polypeptide binding]; other site 1267754001013 23S rRNA interface [nucleotide binding]; other site 1267754001014 L5 interface [polypeptide binding]; other site 1267754001015 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1267754001016 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1267754001017 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1267754001018 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1267754001019 23S rRNA binding site [nucleotide binding]; other site 1267754001020 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1267754001021 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1267754001022 SecY translocase; Region: SecY; pfam00344 1267754001023 adenylate kinase; Reviewed; Region: adk; PRK00279 1267754001024 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1267754001025 AMP-binding site [chemical binding]; other site 1267754001026 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1267754001027 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1267754001028 active site 1267754001029 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1267754001030 rRNA binding site [nucleotide binding]; other site 1267754001031 predicted 30S ribosome binding site; other site 1267754001032 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1267754001033 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1267754001034 30S ribosomal protein S11; Validated; Region: PRK05309 1267754001035 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1267754001036 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1267754001037 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1267754001038 RNA binding surface [nucleotide binding]; other site 1267754001039 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1267754001040 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1267754001041 alphaNTD - beta interaction site [polypeptide binding]; other site 1267754001042 alphaNTD homodimer interface [polypeptide binding]; other site 1267754001043 alphaNTD - beta' interaction site [polypeptide binding]; other site 1267754001044 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1267754001045 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1267754001046 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1267754001047 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1267754001048 dimerization interface 3.5A [polypeptide binding]; other site 1267754001049 active site 1267754001050 Protein of unknown function (DUF690); Region: DUF690; cl04939 1267754001051 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1267754001052 active site 1267754001053 catalytic residues [active] 1267754001054 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1267754001055 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1267754001056 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1267754001057 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1267754001058 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1267754001059 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1267754001060 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1267754001061 DNA methylase; Region: N6_N4_Mtase; pfam01555 1267754001062 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1267754001063 DNA methylase; Region: N6_N4_Mtase; cl17433 1267754001064 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1267754001065 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1267754001066 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1267754001067 23S rRNA interface [nucleotide binding]; other site 1267754001068 L3 interface [polypeptide binding]; other site 1267754001069 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1267754001070 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1267754001071 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1267754001072 dimer interface [polypeptide binding]; other site 1267754001073 substrate binding site [chemical binding]; other site 1267754001074 ATP binding site [chemical binding]; other site 1267754001075 Putative transcription activator [Transcription]; Region: TenA; COG0819 1267754001076 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1267754001077 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1267754001078 active site 1267754001079 substrate binding site [chemical binding]; other site 1267754001080 metal binding site [ion binding]; metal-binding site 1267754001081 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1267754001082 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1267754001083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1267754001084 DNA binding residues [nucleotide binding] 1267754001085 dimer interface [polypeptide binding]; other site 1267754001086 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1267754001087 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1267754001088 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1267754001089 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1267754001090 glutaminase active site [active] 1267754001091 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1267754001092 dimer interface [polypeptide binding]; other site 1267754001093 active site 1267754001094 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1267754001095 dimer interface [polypeptide binding]; other site 1267754001096 active site 1267754001097 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1267754001098 putative substrate binding site [chemical binding]; other site 1267754001099 putative ATP binding site [chemical binding]; other site 1267754001100 alanine racemase; Reviewed; Region: alr; PRK00053 1267754001101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1267754001102 active site 1267754001103 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1267754001104 dimer interface [polypeptide binding]; other site 1267754001105 substrate binding site [chemical binding]; other site 1267754001106 catalytic residues [active] 1267754001107 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1267754001108 RNA polymerase I specific transcription initiation factor RRN3; Region: RRN3; pfam05327 1267754001109 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1267754001110 Glycoprotease family; Region: Peptidase_M22; pfam00814 1267754001111 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1267754001112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1267754001113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1267754001114 Coenzyme A binding pocket [chemical binding]; other site 1267754001115 UGMP family protein; Validated; Region: PRK09604 1267754001116 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1267754001117 oligomerisation interface [polypeptide binding]; other site 1267754001118 mobile loop; other site 1267754001119 roof hairpin; other site 1267754001120 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1267754001121 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1267754001122 ring oligomerisation interface [polypeptide binding]; other site 1267754001123 ATP/Mg binding site [chemical binding]; other site 1267754001124 stacking interactions; other site 1267754001125 hinge regions; other site 1267754001126 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1267754001127 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1267754001128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1267754001129 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1267754001130 active site 1267754001131 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1267754001132 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1267754001133 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1267754001134 phosphate binding site [ion binding]; other site 1267754001135 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754001136 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1267754001137 intersubunit interface [polypeptide binding]; other site 1267754001138 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1267754001139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754001140 ABC-ATPase subunit interface; other site 1267754001141 dimer interface [polypeptide binding]; other site 1267754001142 putative PBP binding regions; other site 1267754001143 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1267754001144 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754001145 Walker A/P-loop; other site 1267754001146 ATP binding site [chemical binding]; other site 1267754001147 Q-loop/lid; other site 1267754001148 ABC transporter signature motif; other site 1267754001149 Walker B; other site 1267754001150 D-loop; other site 1267754001151 H-loop/switch region; other site 1267754001152 GMP synthase; Reviewed; Region: guaA; PRK00074 1267754001153 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1267754001154 AMP/PPi binding site [chemical binding]; other site 1267754001155 candidate oxyanion hole; other site 1267754001156 catalytic triad [active] 1267754001157 potential glutamine specificity residues [chemical binding]; other site 1267754001158 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1267754001159 ATP Binding subdomain [chemical binding]; other site 1267754001160 Ligand Binding sites [chemical binding]; other site 1267754001161 Dimerization subdomain; other site 1267754001162 DNA Polymerase Y-family; Region: PolY_like; cd03468 1267754001163 active site 1267754001164 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1267754001165 DNA binding site [nucleotide binding] 1267754001166 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1267754001167 putative dimer interface [polypeptide binding]; other site 1267754001168 putative [2Fe-2S] cluster binding site [ion binding]; other site 1267754001169 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1267754001170 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1267754001171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754001172 dimer interface [polypeptide binding]; other site 1267754001173 conserved gate region; other site 1267754001174 putative PBP binding loops; other site 1267754001175 ABC-ATPase subunit interface; other site 1267754001176 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1267754001177 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1267754001178 Walker A/P-loop; other site 1267754001179 ATP binding site [chemical binding]; other site 1267754001180 Q-loop/lid; other site 1267754001181 ABC transporter signature motif; other site 1267754001182 Walker B; other site 1267754001183 D-loop; other site 1267754001184 H-loop/switch region; other site 1267754001185 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1267754001186 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1267754001187 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1267754001188 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1267754001189 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1267754001190 active site 1267754001191 PHP Thumb interface [polypeptide binding]; other site 1267754001192 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1267754001193 generic binding surface II; other site 1267754001194 generic binding surface I; other site 1267754001195 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1267754001196 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1267754001197 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1267754001198 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1267754001199 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1267754001200 Walker A/P-loop; other site 1267754001201 ATP binding site [chemical binding]; other site 1267754001202 Q-loop/lid; other site 1267754001203 ABC transporter signature motif; other site 1267754001204 Walker B; other site 1267754001205 D-loop; other site 1267754001206 H-loop/switch region; other site 1267754001207 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1267754001208 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1267754001209 Walker A/P-loop; other site 1267754001210 ATP binding site [chemical binding]; other site 1267754001211 Q-loop/lid; other site 1267754001212 ABC transporter signature motif; other site 1267754001213 Walker B; other site 1267754001214 D-loop; other site 1267754001215 H-loop/switch region; other site 1267754001216 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1267754001217 hypothetical protein; Provisional; Region: PRK06547 1267754001218 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1267754001219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754001220 NAD(P) binding site [chemical binding]; other site 1267754001221 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1267754001222 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1267754001223 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1267754001224 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1267754001225 homodimer interface [polypeptide binding]; other site 1267754001226 NADP binding site [chemical binding]; other site 1267754001227 substrate binding site [chemical binding]; other site 1267754001228 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1267754001229 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1267754001230 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1267754001231 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1267754001232 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1267754001233 homodimer interface [polypeptide binding]; other site 1267754001234 substrate-cofactor binding pocket; other site 1267754001235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754001236 catalytic residue [active] 1267754001237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1267754001238 MOSC domain; Region: MOSC; pfam03473 1267754001239 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1267754001240 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1267754001241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754001242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754001243 putative substrate translocation pore; other site 1267754001244 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1267754001245 putative catalytic site [active] 1267754001246 putative metal binding site [ion binding]; other site 1267754001247 putative phosphate binding site [ion binding]; other site 1267754001248 Predicted membrane protein [Function unknown]; Region: COG2860 1267754001249 UPF0126 domain; Region: UPF0126; pfam03458 1267754001250 UPF0126 domain; Region: UPF0126; pfam03458 1267754001251 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1267754001252 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1267754001253 active site 1267754001254 HIGH motif; other site 1267754001255 dimer interface [polypeptide binding]; other site 1267754001256 KMSKS motif; other site 1267754001257 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1267754001258 adenosine deaminase; Provisional; Region: PRK09358 1267754001259 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1267754001260 active site 1267754001261 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1267754001262 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1267754001263 putative ligand binding site [chemical binding]; other site 1267754001264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1267754001265 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1267754001266 TM-ABC transporter signature motif; other site 1267754001267 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1267754001268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754001269 Walker A/P-loop; other site 1267754001270 ATP binding site [chemical binding]; other site 1267754001271 Q-loop/lid; other site 1267754001272 ABC transporter signature motif; other site 1267754001273 Walker B; other site 1267754001274 D-loop; other site 1267754001275 H-loop/switch region; other site 1267754001276 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1267754001277 NlpC/P60 family; Region: NLPC_P60; pfam00877 1267754001278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754001279 active site 1267754001280 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1267754001281 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1267754001282 active site 1267754001283 substrate binding site [chemical binding]; other site 1267754001284 metal binding site [ion binding]; metal-binding site 1267754001285 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1267754001286 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1267754001287 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1267754001288 metal binding site [ion binding]; metal-binding site 1267754001289 putative dimer interface [polypeptide binding]; other site 1267754001290 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1267754001291 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1267754001292 glycerol kinase; Provisional; Region: glpK; PRK00047 1267754001293 N- and C-terminal domain interface [polypeptide binding]; other site 1267754001294 active site 1267754001295 MgATP binding site [chemical binding]; other site 1267754001296 catalytic site [active] 1267754001297 metal binding site [ion binding]; metal-binding site 1267754001298 putative homotetramer interface [polypeptide binding]; other site 1267754001299 glycerol binding site [chemical binding]; other site 1267754001300 homodimer interface [polypeptide binding]; other site 1267754001301 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1267754001302 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1267754001303 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1267754001304 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1267754001305 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1267754001306 carboxyltransferase (CT) interaction site; other site 1267754001307 biotinylation site [posttranslational modification]; other site 1267754001308 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1267754001309 citrate synthase; Provisional; Region: PRK14033 1267754001310 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1267754001311 dimer interface [polypeptide binding]; other site 1267754001312 active site 1267754001313 citrylCoA binding site [chemical binding]; other site 1267754001314 oxalacetate/citrate binding site [chemical binding]; other site 1267754001315 coenzyme A binding site [chemical binding]; other site 1267754001316 catalytic triad [active] 1267754001317 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1267754001318 active site 1267754001319 dimer interface [polypeptide binding]; other site 1267754001320 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1267754001321 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1267754001322 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1267754001323 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1267754001324 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1267754001325 ATP-grasp domain; Region: ATP-grasp; pfam02222 1267754001326 AIR carboxylase; Region: AIRC; pfam00731 1267754001327 biotin synthase; Validated; Region: PRK06256 1267754001328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1267754001329 FeS/SAM binding site; other site 1267754001330 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1267754001331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1267754001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754001333 dimer interface [polypeptide binding]; other site 1267754001334 conserved gate region; other site 1267754001335 putative PBP binding loops; other site 1267754001336 ABC-ATPase subunit interface; other site 1267754001337 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1267754001338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754001339 dimer interface [polypeptide binding]; other site 1267754001340 conserved gate region; other site 1267754001341 putative PBP binding loops; other site 1267754001342 ABC-ATPase subunit interface; other site 1267754001343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1267754001344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1267754001345 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1267754001346 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1267754001347 Walker A/P-loop; other site 1267754001348 ATP binding site [chemical binding]; other site 1267754001349 Q-loop/lid; other site 1267754001350 ABC transporter signature motif; other site 1267754001351 Walker B; other site 1267754001352 D-loop; other site 1267754001353 H-loop/switch region; other site 1267754001354 TOBE domain; Region: TOBE_2; pfam08402 1267754001355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1267754001356 Histidine kinase; Region: HisKA_3; pfam07730 1267754001357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754001358 ATP binding site [chemical binding]; other site 1267754001359 Mg2+ binding site [ion binding]; other site 1267754001360 G-X-G motif; other site 1267754001361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1267754001362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754001363 active site 1267754001364 phosphorylation site [posttranslational modification] 1267754001365 intermolecular recognition site; other site 1267754001366 dimerization interface [polypeptide binding]; other site 1267754001367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1267754001368 DNA binding residues [nucleotide binding] 1267754001369 dimerization interface [polypeptide binding]; other site 1267754001370 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1267754001371 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1267754001372 Walker A/P-loop; other site 1267754001373 ATP binding site [chemical binding]; other site 1267754001374 Q-loop/lid; other site 1267754001375 ABC transporter signature motif; other site 1267754001376 Walker B; other site 1267754001377 D-loop; other site 1267754001378 H-loop/switch region; other site 1267754001379 TIGR03089 family protein; Region: TIGR03089 1267754001380 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1267754001381 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1267754001382 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1267754001383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754001384 active site 1267754001385 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1267754001386 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1267754001387 Probable Catalytic site; other site 1267754001388 metal-binding site 1267754001389 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1267754001390 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1267754001391 active site 1267754001392 Substrate binding site; other site 1267754001393 Mg++ binding site; other site 1267754001394 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1267754001395 putative trimer interface [polypeptide binding]; other site 1267754001396 putative CoA binding site [chemical binding]; other site 1267754001397 Transcription factor WhiB; Region: Whib; pfam02467 1267754001398 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1267754001399 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1267754001400 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1267754001401 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1267754001402 active site 1267754001403 substrate binding site [chemical binding]; other site 1267754001404 metal binding site [ion binding]; metal-binding site 1267754001405 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 1267754001406 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1267754001407 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1267754001408 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1267754001409 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1267754001410 homotetramer interface [polypeptide binding]; other site 1267754001411 ligand binding site [chemical binding]; other site 1267754001412 catalytic site [active] 1267754001413 NAD binding site [chemical binding]; other site 1267754001414 thymidylate kinase; Validated; Region: PRK07933 1267754001415 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1267754001416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754001417 active site 1267754001418 phosphorylation site [posttranslational modification] 1267754001419 intermolecular recognition site; other site 1267754001420 dimerization interface [polypeptide binding]; other site 1267754001421 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1267754001422 DNA binding site [nucleotide binding] 1267754001423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1267754001424 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1267754001425 dimerization interface [polypeptide binding]; other site 1267754001426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1267754001427 dimer interface [polypeptide binding]; other site 1267754001428 phosphorylation site [posttranslational modification] 1267754001429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754001430 ATP binding site [chemical binding]; other site 1267754001431 Mg2+ binding site [ion binding]; other site 1267754001432 G-X-G motif; other site 1267754001433 lipoprotein LpqB; Provisional; Region: PRK13616 1267754001434 Sporulation and spore germination; Region: Germane; pfam10646 1267754001435 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1267754001436 30S subunit binding site; other site 1267754001437 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1267754001438 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1267754001439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1267754001440 nucleotide binding region [chemical binding]; other site 1267754001441 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1267754001442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754001443 motif II; other site 1267754001444 Predicted GTPases [General function prediction only]; Region: COG1162 1267754001445 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1267754001446 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1267754001447 GTP/Mg2+ binding site [chemical binding]; other site 1267754001448 G4 box; other site 1267754001449 G1 box; other site 1267754001450 Switch I region; other site 1267754001451 G2 box; other site 1267754001452 G3 box; other site 1267754001453 Switch II region; other site 1267754001454 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1267754001455 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1267754001456 hinge; other site 1267754001457 active site 1267754001458 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1267754001459 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1267754001460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1267754001461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1267754001462 DNA binding residues [nucleotide binding] 1267754001463 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1267754001464 Transcription factor WhiB; Region: Whib; pfam02467 1267754001465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1267754001466 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1267754001467 ATP binding site [chemical binding]; other site 1267754001468 putative Mg++ binding site [ion binding]; other site 1267754001469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754001470 nucleotide binding region [chemical binding]; other site 1267754001471 ATP-binding site [chemical binding]; other site 1267754001472 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1267754001473 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1267754001474 TIGR02569 family protein; Region: TIGR02569_actnb 1267754001475 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1267754001476 Part of AAA domain; Region: AAA_19; pfam13245 1267754001477 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1267754001478 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1267754001479 Part of AAA domain; Region: AAA_19; pfam13245 1267754001480 Family description; Region: UvrD_C_2; pfam13538 1267754001481 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1267754001482 Ion channel; Region: Ion_trans_2; pfam07885 1267754001483 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1267754001484 TrkA-N domain; Region: TrkA_N; pfam02254 1267754001485 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1267754001486 Part of AAA domain; Region: AAA_19; pfam13245 1267754001487 Family description; Region: UvrD_C_2; pfam13538 1267754001488 HRDC domain; Region: HRDC; pfam00570 1267754001489 Protein of unknown function DUF45; Region: DUF45; pfam01863 1267754001490 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1267754001491 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1267754001492 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1267754001493 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1267754001494 hypothetical protein; Validated; Region: PRK00068 1267754001495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754001496 putative substrate translocation pore; other site 1267754001497 Cupin domain; Region: Cupin_2; cl17218 1267754001498 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1267754001499 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1267754001500 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1267754001501 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1267754001502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754001503 ABC-ATPase subunit interface; other site 1267754001504 dimer interface [polypeptide binding]; other site 1267754001505 putative PBP binding regions; other site 1267754001506 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1267754001507 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754001508 intersubunit interface [polypeptide binding]; other site 1267754001509 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1267754001510 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1267754001511 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1267754001512 hypothetical protein; Provisional; Region: PRK07857 1267754001513 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1267754001514 Part of AAA domain; Region: AAA_19; pfam13245 1267754001515 Family description; Region: UvrD_C_2; pfam13538 1267754001516 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1267754001517 Peptidase family M23; Region: Peptidase_M23; pfam01551 1267754001518 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1267754001519 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1267754001520 active site 1267754001521 substrate binding site [chemical binding]; other site 1267754001522 cosubstrate binding site; other site 1267754001523 catalytic site [active] 1267754001524 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1267754001525 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1267754001526 purine monophosphate binding site [chemical binding]; other site 1267754001527 dimer interface [polypeptide binding]; other site 1267754001528 putative catalytic residues [active] 1267754001529 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1267754001530 putative acyltransferase; Provisional; Region: PRK05790 1267754001531 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1267754001532 dimer interface [polypeptide binding]; other site 1267754001533 active site 1267754001534 Predicted permeases [General function prediction only]; Region: COG0679 1267754001535 Vacuolar segregation subunit 7; Region: Vac7; pfam12751 1267754001536 RDD family; Region: RDD; pfam06271 1267754001537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1267754001538 hypothetical protein; Provisional; Region: PRK13663 1267754001539 30S ribosomal protein S18; Provisional; Region: PRK13401 1267754001540 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1267754001541 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1267754001542 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1267754001543 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1267754001544 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1267754001545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1267754001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754001547 active site 1267754001548 phosphorylation site [posttranslational modification] 1267754001549 intermolecular recognition site; other site 1267754001550 dimerization interface [polypeptide binding]; other site 1267754001551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1267754001552 DNA binding site [nucleotide binding] 1267754001553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1267754001554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1267754001555 dimerization interface [polypeptide binding]; other site 1267754001556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1267754001557 dimer interface [polypeptide binding]; other site 1267754001558 phosphorylation site [posttranslational modification] 1267754001559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754001560 ATP binding site [chemical binding]; other site 1267754001561 Mg2+ binding site [ion binding]; other site 1267754001562 G-X-G motif; other site 1267754001563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1267754001564 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1267754001565 protein binding site [polypeptide binding]; other site 1267754001566 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1267754001567 MPT binding site; other site 1267754001568 trimer interface [polypeptide binding]; other site 1267754001569 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1267754001570 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1267754001571 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1267754001572 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1267754001573 active site 1267754001574 tetramer interface; other site 1267754001575 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1267754001576 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1267754001577 dimer interface [polypeptide binding]; other site 1267754001578 putative functional site; other site 1267754001579 putative MPT binding site; other site 1267754001580 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1267754001581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1267754001582 Predicted membrane protein [Function unknown]; Region: COG2259 1267754001583 Predicted integral membrane protein [Function unknown]; Region: COG5660 1267754001584 Putative zinc-finger; Region: zf-HC2; pfam13490 1267754001585 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1267754001586 Predicted methyltransferases [General function prediction only]; Region: COG0313 1267754001587 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1267754001588 putative SAM binding site [chemical binding]; other site 1267754001589 putative homodimer interface [polypeptide binding]; other site 1267754001590 BCCT family transporter; Region: BCCT; pfam02028 1267754001591 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1267754001592 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1267754001593 active site 1267754001594 nucleotide binding site [chemical binding]; other site 1267754001595 HIGH motif; other site 1267754001596 KMSKS motif; other site 1267754001597 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1267754001598 tRNA binding surface [nucleotide binding]; other site 1267754001599 anticodon binding site; other site 1267754001600 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1267754001601 active site 1267754001602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1267754001603 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1267754001604 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1267754001605 G5 domain; Region: G5; pfam07501 1267754001606 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1267754001607 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1267754001608 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1267754001609 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1267754001610 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1267754001611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754001612 Walker A/P-loop; other site 1267754001613 ATP binding site [chemical binding]; other site 1267754001614 Q-loop/lid; other site 1267754001615 ABC transporter signature motif; other site 1267754001616 Walker B; other site 1267754001617 D-loop; other site 1267754001618 H-loop/switch region; other site 1267754001619 ABC transporter; Region: ABC_tran_2; pfam12848 1267754001620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1267754001621 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1267754001622 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1267754001623 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754001624 substrate binding site [chemical binding]; other site 1267754001625 oxyanion hole (OAH) forming residues; other site 1267754001626 trimer interface [polypeptide binding]; other site 1267754001627 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1267754001628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754001629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754001630 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1267754001631 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1267754001632 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1267754001633 G1 box; other site 1267754001634 putative GEF interaction site [polypeptide binding]; other site 1267754001635 GTP/Mg2+ binding site [chemical binding]; other site 1267754001636 Switch I region; other site 1267754001637 G2 box; other site 1267754001638 G3 box; other site 1267754001639 Switch II region; other site 1267754001640 G4 box; other site 1267754001641 G5 box; other site 1267754001642 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1267754001643 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1267754001644 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1267754001645 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1267754001646 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1267754001647 putative active site [active] 1267754001648 catalytic residue [active] 1267754001649 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1267754001650 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1267754001651 5S rRNA interface [nucleotide binding]; other site 1267754001652 CTC domain interface [polypeptide binding]; other site 1267754001653 L16 interface [polypeptide binding]; other site 1267754001654 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1267754001655 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1267754001656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754001657 active site 1267754001658 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1267754001659 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1267754001660 Substrate binding site; other site 1267754001661 Mg++ binding site; other site 1267754001662 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1267754001663 active site 1267754001664 substrate binding site [chemical binding]; other site 1267754001665 CoA binding site [chemical binding]; other site 1267754001666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754001667 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1267754001668 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1267754001669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754001670 ATP binding site [chemical binding]; other site 1267754001671 putative Mg++ binding site [ion binding]; other site 1267754001672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754001673 nucleotide binding region [chemical binding]; other site 1267754001674 ATP-binding site [chemical binding]; other site 1267754001675 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1267754001676 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1267754001677 homodimer interface [polypeptide binding]; other site 1267754001678 metal binding site [ion binding]; metal-binding site 1267754001679 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1267754001680 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1267754001681 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1267754001682 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1267754001683 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1267754001684 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1267754001685 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1267754001686 enolase; Provisional; Region: eno; PRK00077 1267754001687 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1267754001688 dimer interface [polypeptide binding]; other site 1267754001689 metal binding site [ion binding]; metal-binding site 1267754001690 substrate binding pocket [chemical binding]; other site 1267754001691 Septum formation initiator; Region: DivIC; pfam04977 1267754001692 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1267754001693 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1267754001694 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1267754001695 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1267754001696 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1267754001697 short chain dehydrogenase; Provisional; Region: PRK08219 1267754001698 classical (c) SDRs; Region: SDR_c; cd05233 1267754001699 NAD(P) binding site [chemical binding]; other site 1267754001700 active site 1267754001701 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1267754001702 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1267754001703 NAD(P) binding site [chemical binding]; other site 1267754001704 catalytic residues [active] 1267754001705 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1267754001706 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1267754001707 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1267754001708 substrate binding site [chemical binding]; other site 1267754001709 dimer interface [polypeptide binding]; other site 1267754001710 NADP binding site [chemical binding]; other site 1267754001711 catalytic residues [active] 1267754001712 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1267754001713 active site 2 [active] 1267754001714 active site 1 [active] 1267754001715 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1267754001716 CoenzymeA binding site [chemical binding]; other site 1267754001717 subunit interaction site [polypeptide binding]; other site 1267754001718 PHB binding site; other site 1267754001719 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1267754001720 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1267754001721 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1267754001722 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1267754001723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754001724 substrate binding site [chemical binding]; other site 1267754001725 oxyanion hole (OAH) forming residues; other site 1267754001726 trimer interface [polypeptide binding]; other site 1267754001727 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1267754001728 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1267754001729 dimer interface [polypeptide binding]; other site 1267754001730 active site 1267754001731 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1267754001732 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754001733 substrate binding site [chemical binding]; other site 1267754001734 oxyanion hole (OAH) forming residues; other site 1267754001735 trimer interface [polypeptide binding]; other site 1267754001736 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1267754001737 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1267754001738 FAD binding pocket [chemical binding]; other site 1267754001739 FAD binding motif [chemical binding]; other site 1267754001740 phosphate binding motif [ion binding]; other site 1267754001741 beta-alpha-beta structure motif; other site 1267754001742 NAD(p) ribose binding residues [chemical binding]; other site 1267754001743 NAD binding pocket [chemical binding]; other site 1267754001744 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1267754001745 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1267754001746 catalytic loop [active] 1267754001747 iron binding site [ion binding]; other site 1267754001748 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1267754001749 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1267754001750 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1267754001751 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1267754001752 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1267754001753 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1267754001754 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1267754001755 CoenzymeA binding site [chemical binding]; other site 1267754001756 subunit interaction site [polypeptide binding]; other site 1267754001757 PHB binding site; other site 1267754001758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754001759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754001760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754001761 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1267754001762 acyl-activating enzyme (AAE) consensus motif; other site 1267754001763 AMP binding site [chemical binding]; other site 1267754001764 active site 1267754001765 CoA binding site [chemical binding]; other site 1267754001766 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1267754001767 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1267754001768 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1267754001769 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1267754001770 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1267754001771 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1267754001772 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1267754001773 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1267754001774 catalytic residue [active] 1267754001775 putative FPP diphosphate binding site; other site 1267754001776 putative FPP binding hydrophobic cleft; other site 1267754001777 dimer interface [polypeptide binding]; other site 1267754001778 putative IPP diphosphate binding site; other site 1267754001779 pantothenate kinase; Provisional; Region: PRK05439 1267754001780 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1267754001781 ATP-binding site [chemical binding]; other site 1267754001782 CoA-binding site [chemical binding]; other site 1267754001783 Mg2+-binding site [ion binding]; other site 1267754001784 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1267754001785 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1267754001786 dimer interface [polypeptide binding]; other site 1267754001787 active site 1267754001788 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1267754001789 folate binding site [chemical binding]; other site 1267754001790 Isochorismatase family; Region: Isochorismatase; pfam00857 1267754001791 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1267754001792 catalytic triad [active] 1267754001793 metal binding site [ion binding]; metal-binding site 1267754001794 conserved cis-peptide bond; other site 1267754001795 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1267754001796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754001797 active site 1267754001798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1267754001799 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1267754001800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1267754001801 Coenzyme A binding pocket [chemical binding]; other site 1267754001802 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1267754001803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754001804 putative substrate translocation pore; other site 1267754001805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754001806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754001807 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1267754001808 Class II fumarases; Region: Fumarase_classII; cd01362 1267754001809 active site 1267754001810 tetramer interface [polypeptide binding]; other site 1267754001811 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1267754001812 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1267754001813 putative active site [active] 1267754001814 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1267754001815 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1267754001816 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1267754001817 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1267754001818 generic binding surface II; other site 1267754001819 generic binding surface I; other site 1267754001820 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 1267754001821 Alcohol dehydrogenase transcription factor Myb/SANT-like; Region: MADF_DNA_bdg; cl17739 1267754001822 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1267754001823 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1267754001824 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1267754001825 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1267754001826 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1267754001827 Na2 binding site [ion binding]; other site 1267754001828 putative substrate binding site 1 [chemical binding]; other site 1267754001829 Na binding site 1 [ion binding]; other site 1267754001830 putative substrate binding site 2 [chemical binding]; other site 1267754001831 GTP-binding protein YchF; Reviewed; Region: PRK09601 1267754001832 YchF GTPase; Region: YchF; cd01900 1267754001833 G1 box; other site 1267754001834 GTP/Mg2+ binding site [chemical binding]; other site 1267754001835 Switch I region; other site 1267754001836 G2 box; other site 1267754001837 Switch II region; other site 1267754001838 G3 box; other site 1267754001839 G4 box; other site 1267754001840 G5 box; other site 1267754001841 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1267754001842 Abi-like protein; Region: Abi_2; pfam07751 1267754001843 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1267754001844 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1267754001845 catalytic residues [active] 1267754001846 catalytic nucleophile [active] 1267754001847 Recombinase; Region: Recombinase; pfam07508 1267754001848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1267754001849 Abi-like protein; Region: Abi_2; pfam07751 1267754001850 hypothetical protein; Provisional; Region: PRK09256 1267754001851 mercuric reductase; Region: MerA; TIGR02053 1267754001852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1267754001853 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1267754001854 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1267754001855 DNA binding residues [nucleotide binding] 1267754001856 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1267754001857 dimer interface [polypeptide binding]; other site 1267754001858 metal binding site [ion binding]; metal-binding site 1267754001859 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1267754001860 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1267754001861 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1267754001862 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1267754001863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1267754001864 dimerization interface [polypeptide binding]; other site 1267754001865 putative DNA binding site [nucleotide binding]; other site 1267754001866 putative Zn2+ binding site [ion binding]; other site 1267754001867 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1267754001868 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 1267754001869 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1267754001870 Protein of unknown function DUF262; Region: DUF262; pfam03235 1267754001871 Protein of unknown function DUF262; Region: DUF262; pfam03235 1267754001872 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1267754001873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1267754001874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1267754001875 dimerization interface [polypeptide binding]; other site 1267754001876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1267754001877 dimer interface [polypeptide binding]; other site 1267754001878 phosphorylation site [posttranslational modification] 1267754001879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754001880 ATP binding site [chemical binding]; other site 1267754001881 Mg2+ binding site [ion binding]; other site 1267754001882 G-X-G motif; other site 1267754001883 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1267754001884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754001885 active site 1267754001886 phosphorylation site [posttranslational modification] 1267754001887 intermolecular recognition site; other site 1267754001888 dimerization interface [polypeptide binding]; other site 1267754001889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1267754001890 DNA binding site [nucleotide binding] 1267754001891 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1267754001892 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1267754001893 active site 1267754001894 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1267754001895 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1267754001896 nudix motif; other site 1267754001897 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1267754001898 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1267754001899 pyruvate dehydrogenase; Provisional; Region: PRK06546 1267754001900 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1267754001901 PYR/PP interface [polypeptide binding]; other site 1267754001902 tetramer interface [polypeptide binding]; other site 1267754001903 dimer interface [polypeptide binding]; other site 1267754001904 TPP binding site [chemical binding]; other site 1267754001905 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1267754001906 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1267754001907 TPP-binding site [chemical binding]; other site 1267754001908 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1267754001909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1267754001910 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1267754001911 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1267754001912 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1267754001913 active site 1267754001914 nucleophile elbow; other site 1267754001915 Protein of unknown function (DUF808); Region: DUF808; cl01002 1267754001916 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1267754001917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1267754001918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754001919 active site 1267754001920 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1267754001921 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1267754001922 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1267754001923 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1267754001924 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1267754001925 G1 box; other site 1267754001926 putative GEF interaction site [polypeptide binding]; other site 1267754001927 GTP/Mg2+ binding site [chemical binding]; other site 1267754001928 Switch I region; other site 1267754001929 G2 box; other site 1267754001930 G3 box; other site 1267754001931 Switch II region; other site 1267754001932 G4 box; other site 1267754001933 G5 box; other site 1267754001934 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1267754001935 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1267754001936 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1267754001937 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1267754001938 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1267754001939 Ferredoxin [Energy production and conversion]; Region: COG1146 1267754001940 4Fe-4S binding domain; Region: Fer4; cl02805 1267754001941 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1267754001942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1267754001943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754001944 homodimer interface [polypeptide binding]; other site 1267754001945 catalytic residue [active] 1267754001946 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1267754001947 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1267754001948 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1267754001949 DivIVA domain; Region: DivI1A_domain; TIGR03544 1267754001950 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1267754001951 interface (dimer of trimers) [polypeptide binding]; other site 1267754001952 Substrate-binding/catalytic site; other site 1267754001953 Zn-binding sites [ion binding]; other site 1267754001954 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1267754001955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754001956 S-adenosylmethionine binding site [chemical binding]; other site 1267754001957 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1267754001958 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1267754001959 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1267754001960 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1267754001961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1267754001962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1267754001963 DNA binding residues [nucleotide binding] 1267754001964 Putative zinc-finger; Region: zf-HC2; pfam13490 1267754001965 sec-independent translocase; Provisional; Region: tatB; PRK00182 1267754001966 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1267754001967 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1267754001968 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1267754001969 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1267754001970 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1267754001971 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1267754001972 MgtE intracellular N domain; Region: MgtE_N; smart00924 1267754001973 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1267754001974 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1267754001975 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1267754001976 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1267754001977 TPP-binding site [chemical binding]; other site 1267754001978 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1267754001979 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1267754001980 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1267754001981 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1267754001982 Walker A/P-loop; other site 1267754001983 ATP binding site [chemical binding]; other site 1267754001984 Q-loop/lid; other site 1267754001985 ABC transporter signature motif; other site 1267754001986 Walker B; other site 1267754001987 D-loop; other site 1267754001988 H-loop/switch region; other site 1267754001989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1267754001990 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1267754001991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754001992 Walker A/P-loop; other site 1267754001993 ATP binding site [chemical binding]; other site 1267754001994 Q-loop/lid; other site 1267754001995 ABC transporter signature motif; other site 1267754001996 Walker B; other site 1267754001997 D-loop; other site 1267754001998 H-loop/switch region; other site 1267754001999 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1267754002000 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1267754002001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1267754002002 putative transposase OrfB; Reviewed; Region: PHA02517 1267754002003 HTH-like domain; Region: HTH_21; pfam13276 1267754002004 Integrase core domain; Region: rve; pfam00665 1267754002005 Integrase core domain; Region: rve_2; pfam13333 1267754002006 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1267754002007 Spore germination protein; Region: Spore_permease; cl17796 1267754002008 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1267754002009 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1267754002010 ATP binding site [chemical binding]; other site 1267754002011 Mg++ binding site [ion binding]; other site 1267754002012 motif III; other site 1267754002013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754002014 nucleotide binding region [chemical binding]; other site 1267754002015 ATP-binding site [chemical binding]; other site 1267754002016 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1267754002017 putative RNA binding site [nucleotide binding]; other site 1267754002018 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1267754002019 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1267754002020 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1267754002021 Na binding site [ion binding]; other site 1267754002022 SNF2 Helicase protein; Region: DUF3670; pfam12419 1267754002023 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1267754002024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754002025 ATP binding site [chemical binding]; other site 1267754002026 putative Mg++ binding site [ion binding]; other site 1267754002027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754002028 nucleotide binding region [chemical binding]; other site 1267754002029 ATP-binding site [chemical binding]; other site 1267754002030 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1267754002031 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1267754002032 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1267754002033 active site 1267754002034 metal binding site [ion binding]; metal-binding site 1267754002035 DNA binding site [nucleotide binding] 1267754002036 AAA domain; Region: AAA_23; pfam13476 1267754002037 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1267754002038 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1267754002039 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1267754002040 active site 1267754002041 HIGH motif; other site 1267754002042 KMSK motif region; other site 1267754002043 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1267754002044 tRNA binding surface [nucleotide binding]; other site 1267754002045 anticodon binding site; other site 1267754002046 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1267754002047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1267754002048 active site 1267754002049 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1267754002050 substrate binding site [chemical binding]; other site 1267754002051 catalytic residues [active] 1267754002052 dimer interface [polypeptide binding]; other site 1267754002053 homoserine dehydrogenase; Provisional; Region: PRK06349 1267754002054 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1267754002055 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1267754002056 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1267754002057 homoserine kinase; Provisional; Region: PRK01212 1267754002058 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 1267754002059 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1267754002060 ATP binding site [chemical binding]; other site 1267754002061 substrate interface [chemical binding]; other site 1267754002062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1267754002063 active site residue [active] 1267754002064 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1267754002065 MPT binding site; other site 1267754002066 trimer interface [polypeptide binding]; other site 1267754002067 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1267754002068 MoaE interaction surface [polypeptide binding]; other site 1267754002069 MoeB interaction surface [polypeptide binding]; other site 1267754002070 thiocarboxylated glycine; other site 1267754002071 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1267754002072 GTP binding site; other site 1267754002073 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1267754002074 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1267754002075 dimer interface [polypeptide binding]; other site 1267754002076 putative functional site; other site 1267754002077 putative MPT binding site; other site 1267754002078 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1267754002079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1267754002080 FeS/SAM binding site; other site 1267754002081 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1267754002082 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1267754002083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754002084 acyl-activating enzyme (AAE) consensus motif; other site 1267754002085 AMP binding site [chemical binding]; other site 1267754002086 active site 1267754002087 CoA binding site [chemical binding]; other site 1267754002088 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1267754002089 transcription termination factor Rho; Provisional; Region: PRK12608 1267754002090 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1267754002091 RNA binding site [nucleotide binding]; other site 1267754002092 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1267754002093 multimer interface [polypeptide binding]; other site 1267754002094 Walker A motif; other site 1267754002095 ATP binding site [chemical binding]; other site 1267754002096 Walker B motif; other site 1267754002097 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1267754002098 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1267754002099 RF-1 domain; Region: RF-1; pfam00472 1267754002100 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1267754002101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754002102 S-adenosylmethionine binding site [chemical binding]; other site 1267754002103 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1267754002104 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1267754002105 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1267754002106 Mg++ binding site [ion binding]; other site 1267754002107 putative catalytic motif [active] 1267754002108 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1267754002109 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1267754002110 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1267754002111 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1267754002112 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1267754002113 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1267754002114 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1267754002115 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1267754002116 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1267754002117 beta subunit interaction interface [polypeptide binding]; other site 1267754002118 Walker A motif; other site 1267754002119 ATP binding site [chemical binding]; other site 1267754002120 Walker B motif; other site 1267754002121 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1267754002122 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1267754002123 core domain interface [polypeptide binding]; other site 1267754002124 delta subunit interface [polypeptide binding]; other site 1267754002125 epsilon subunit interface [polypeptide binding]; other site 1267754002126 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1267754002127 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1267754002128 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1267754002129 alpha subunit interaction interface [polypeptide binding]; other site 1267754002130 Walker A motif; other site 1267754002131 ATP binding site [chemical binding]; other site 1267754002132 Walker B motif; other site 1267754002133 inhibitor binding site; inhibition site 1267754002134 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1267754002135 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1267754002136 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1267754002137 gamma subunit interface [polypeptide binding]; other site 1267754002138 epsilon subunit interface [polypeptide binding]; other site 1267754002139 LBP interface [polypeptide binding]; other site 1267754002140 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1267754002141 hypothetical protein; Provisional; Region: PRK03298 1267754002142 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1267754002143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1267754002144 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1267754002145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754002146 Walker A/P-loop; other site 1267754002147 ATP binding site [chemical binding]; other site 1267754002148 Q-loop/lid; other site 1267754002149 ABC transporter signature motif; other site 1267754002150 Walker B; other site 1267754002151 D-loop; other site 1267754002152 H-loop/switch region; other site 1267754002153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1267754002154 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1267754002155 Ligand binding site [chemical binding]; other site 1267754002156 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1267754002157 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1267754002158 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1267754002159 Ligand Binding Site [chemical binding]; other site 1267754002160 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1267754002161 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1267754002162 Citrate transporter; Region: CitMHS; pfam03600 1267754002163 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1267754002164 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1267754002165 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1267754002166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754002167 catalytic residue [active] 1267754002168 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1267754002169 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1267754002170 Ligand Binding Site [chemical binding]; other site 1267754002171 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1267754002172 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1267754002173 nucleotide binding pocket [chemical binding]; other site 1267754002174 K-X-D-G motif; other site 1267754002175 catalytic site [active] 1267754002176 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1267754002177 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1267754002178 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1267754002179 Dimer interface [polypeptide binding]; other site 1267754002180 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1267754002181 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1267754002182 active site 1267754002183 catalytic site [active] 1267754002184 substrate binding site [chemical binding]; other site 1267754002185 threonine dehydratase; Reviewed; Region: PRK09224 1267754002186 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1267754002187 tetramer interface [polypeptide binding]; other site 1267754002188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754002189 catalytic residue [active] 1267754002190 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1267754002191 putative Ile/Val binding site [chemical binding]; other site 1267754002192 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1267754002193 putative Ile/Val binding site [chemical binding]; other site 1267754002194 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1267754002195 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1267754002196 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1267754002197 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1267754002198 NUDIX domain; Region: NUDIX; pfam00293 1267754002199 nudix motif; other site 1267754002200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754002201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754002202 putative substrate translocation pore; other site 1267754002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754002204 putative substrate translocation pore; other site 1267754002205 6-phosphofructokinase; Provisional; Region: PRK03202 1267754002206 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1267754002207 active site 1267754002208 ADP/pyrophosphate binding site [chemical binding]; other site 1267754002209 dimerization interface [polypeptide binding]; other site 1267754002210 allosteric effector site; other site 1267754002211 fructose-1,6-bisphosphate binding site; other site 1267754002212 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1267754002213 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1267754002214 GatB domain; Region: GatB_Yqey; smart00845 1267754002215 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1267754002216 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754002217 ABC-ATPase subunit interface; other site 1267754002218 dimer interface [polypeptide binding]; other site 1267754002219 putative PBP binding regions; other site 1267754002220 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1267754002221 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754002222 Walker A/P-loop; other site 1267754002223 ATP binding site [chemical binding]; other site 1267754002224 Q-loop/lid; other site 1267754002225 ABC transporter signature motif; other site 1267754002226 Walker B; other site 1267754002227 D-loop; other site 1267754002228 H-loop/switch region; other site 1267754002229 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1267754002230 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754002231 intersubunit interface [polypeptide binding]; other site 1267754002232 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1267754002233 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1267754002234 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1267754002235 putative dimer interface [polypeptide binding]; other site 1267754002236 N-terminal domain interface [polypeptide binding]; other site 1267754002237 putative substrate binding pocket (H-site) [chemical binding]; other site 1267754002238 Predicted membrane protein [Function unknown]; Region: COG2259 1267754002239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754002240 Walker A/P-loop; other site 1267754002241 ATP binding site [chemical binding]; other site 1267754002242 Q-loop/lid; other site 1267754002243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754002244 ABC transporter signature motif; other site 1267754002245 Walker B; other site 1267754002246 D-loop; other site 1267754002247 H-loop/switch region; other site 1267754002248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754002249 AAA domain; Region: AAA_21; pfam13304 1267754002250 Walker A/P-loop; other site 1267754002251 ATP binding site [chemical binding]; other site 1267754002252 Q-loop/lid; other site 1267754002253 ABC transporter signature motif; other site 1267754002254 Walker B; other site 1267754002255 D-loop; other site 1267754002256 H-loop/switch region; other site 1267754002257 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1267754002258 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1267754002259 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1267754002260 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1267754002261 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1267754002262 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1267754002263 PYR/PP interface [polypeptide binding]; other site 1267754002264 dimer interface [polypeptide binding]; other site 1267754002265 TPP binding site [chemical binding]; other site 1267754002266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1267754002267 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1267754002268 TPP-binding site [chemical binding]; other site 1267754002269 dimer interface [polypeptide binding]; other site 1267754002270 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1267754002271 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1267754002272 putative valine binding site [chemical binding]; other site 1267754002273 dimer interface [polypeptide binding]; other site 1267754002274 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1267754002275 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1267754002276 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1267754002277 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1267754002278 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1267754002279 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1267754002280 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1267754002281 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1267754002282 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1267754002283 active site 1267754002284 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1267754002285 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1267754002286 ligand binding site [chemical binding]; other site 1267754002287 NAD binding site [chemical binding]; other site 1267754002288 dimerization interface [polypeptide binding]; other site 1267754002289 catalytic site [active] 1267754002290 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1267754002291 putative L-serine binding site [chemical binding]; other site 1267754002292 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1267754002293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1267754002294 Walker A/P-loop; other site 1267754002295 ATP binding site [chemical binding]; other site 1267754002296 Q-loop/lid; other site 1267754002297 ABC transporter signature motif; other site 1267754002298 Walker B; other site 1267754002299 D-loop; other site 1267754002300 H-loop/switch region; other site 1267754002301 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1267754002302 tartrate dehydrogenase; Region: TTC; TIGR02089 1267754002303 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1267754002304 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1267754002305 ligand binding site [chemical binding]; other site 1267754002306 flexible hinge region; other site 1267754002307 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1267754002308 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1267754002309 metal binding triad; other site 1267754002310 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1267754002311 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1267754002312 active site 1267754002313 catalytic site [active] 1267754002314 substrate binding site [chemical binding]; other site 1267754002315 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1267754002316 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1267754002317 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1267754002318 isochorismate synthase DhbC; Validated; Region: PRK06923 1267754002319 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1267754002320 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1267754002321 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1267754002322 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1267754002323 active site 1267754002324 HIGH motif; other site 1267754002325 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1267754002326 active site 1267754002327 KMSKS motif; other site 1267754002328 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1267754002329 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1267754002330 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1267754002331 putative di-iron ligands [ion binding]; other site 1267754002332 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1267754002333 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1267754002334 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1267754002335 FAD binding pocket [chemical binding]; other site 1267754002336 FAD binding motif [chemical binding]; other site 1267754002337 phosphate binding motif [ion binding]; other site 1267754002338 beta-alpha-beta structure motif; other site 1267754002339 NAD binding pocket [chemical binding]; other site 1267754002340 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1267754002341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1267754002342 catalytic loop [active] 1267754002343 iron binding site [ion binding]; other site 1267754002344 Predicted membrane protein [Function unknown]; Region: COG1297 1267754002345 putative oligopeptide transporter, OPT family; Region: TIGR00733 1267754002346 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1267754002347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1267754002348 putative DNA binding site [nucleotide binding]; other site 1267754002349 putative Zn2+ binding site [ion binding]; other site 1267754002350 Bacterial transcriptional regulator; Region: IclR; pfam01614 1267754002351 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1267754002352 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1267754002353 substrate binding site [chemical binding]; other site 1267754002354 ligand binding site [chemical binding]; other site 1267754002355 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1267754002356 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1267754002357 substrate binding site [chemical binding]; other site 1267754002358 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1267754002359 active site 1267754002360 Ap6A binding site [chemical binding]; other site 1267754002361 nudix motif; other site 1267754002362 metal binding site [ion binding]; metal-binding site 1267754002363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754002364 catalytic core [active] 1267754002365 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1267754002366 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1267754002367 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1267754002368 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1267754002369 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1267754002370 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1267754002371 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1267754002372 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1267754002373 thiamine monophosphate kinase; Provisional; Region: PRK05731 1267754002374 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1267754002375 ATP binding site [chemical binding]; other site 1267754002376 dimerization interface [polypeptide binding]; other site 1267754002377 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1267754002378 ligand binding site [chemical binding]; other site 1267754002379 active site 1267754002380 UGI interface [polypeptide binding]; other site 1267754002381 catalytic site [active] 1267754002382 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1267754002383 DAK2 domain; Region: Dak2; pfam02734 1267754002384 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1267754002385 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1267754002386 generic binding surface II; other site 1267754002387 ssDNA binding site; other site 1267754002388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754002389 ATP binding site [chemical binding]; other site 1267754002390 putative Mg++ binding site [ion binding]; other site 1267754002391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754002392 nucleotide binding region [chemical binding]; other site 1267754002393 ATP-binding site [chemical binding]; other site 1267754002394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1267754002395 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1267754002396 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1267754002397 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1267754002398 active site 1267754002399 (T/H)XGH motif; other site 1267754002400 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1267754002401 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1267754002402 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1267754002403 ribonuclease III; Reviewed; Region: rnc; PRK00102 1267754002404 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1267754002405 dimerization interface [polypeptide binding]; other site 1267754002406 active site 1267754002407 metal binding site [ion binding]; metal-binding site 1267754002408 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1267754002409 dsRNA binding site [nucleotide binding]; other site 1267754002410 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1267754002411 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1267754002412 DNA binding site [nucleotide binding] 1267754002413 catalytic residue [active] 1267754002414 H2TH interface [polypeptide binding]; other site 1267754002415 putative catalytic residues [active] 1267754002416 turnover-facilitating residue; other site 1267754002417 intercalation triad [nucleotide binding]; other site 1267754002418 8OG recognition residue [nucleotide binding]; other site 1267754002419 putative reading head residues; other site 1267754002420 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1267754002421 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1267754002422 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1267754002423 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1267754002424 Acylphosphatase; Region: Acylphosphatase; cl00551 1267754002425 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1267754002426 AAA domain; Region: AAA_23; pfam13476 1267754002427 Walker A/P-loop; other site 1267754002428 ATP binding site [chemical binding]; other site 1267754002429 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1267754002430 ABC transporter signature motif; other site 1267754002431 Walker B; other site 1267754002432 D-loop; other site 1267754002433 H-loop/switch region; other site 1267754002434 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1267754002435 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1267754002436 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1267754002437 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1267754002438 signal recognition particle protein; Provisional; Region: PRK10867 1267754002439 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1267754002440 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1267754002441 P loop; other site 1267754002442 GTP binding site [chemical binding]; other site 1267754002443 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1267754002444 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1267754002445 hypothetical protein; Validated; Region: PRK00029 1267754002446 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1267754002447 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1267754002448 glutamate dehydrogenase; Provisional; Region: PRK09414 1267754002449 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1267754002450 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1267754002451 NAD(P) binding site [chemical binding]; other site 1267754002452 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1267754002453 RimM N-terminal domain; Region: RimM; pfam01782 1267754002454 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1267754002455 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1267754002456 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1267754002457 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1267754002458 BCCT family transporter; Region: BCCT; cl00569 1267754002459 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1267754002460 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1267754002461 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1267754002462 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1267754002463 RNA binding site [nucleotide binding]; other site 1267754002464 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1267754002465 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1267754002466 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1267754002467 Catalytic site [active] 1267754002468 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1267754002469 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1267754002470 RNA/DNA hybrid binding site [nucleotide binding]; other site 1267754002471 active site 1267754002472 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1267754002473 hypothetical protein; Reviewed; Region: PRK12497 1267754002474 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1267754002475 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1267754002476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754002477 Walker A motif; other site 1267754002478 ATP binding site [chemical binding]; other site 1267754002479 Walker B motif; other site 1267754002480 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1267754002481 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1267754002482 DNA protecting protein DprA; Region: dprA; TIGR00732 1267754002483 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1267754002484 DNA binding site [nucleotide binding] 1267754002485 sequence specific DNA binding site [nucleotide binding]; other site 1267754002486 putative cAMP binding site [chemical binding]; other site 1267754002487 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1267754002488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1267754002489 active site 1267754002490 DNA binding site [nucleotide binding] 1267754002491 Int/Topo IB signature motif; other site 1267754002492 Peptidase family M23; Region: Peptidase_M23; pfam01551 1267754002493 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1267754002494 rRNA interaction site [nucleotide binding]; other site 1267754002495 S8 interaction site; other site 1267754002496 putative laminin-1 binding site; other site 1267754002497 elongation factor Ts; Provisional; Region: tsf; PRK09377 1267754002498 UBA/TS-N domain; Region: UBA; pfam00627 1267754002499 Elongation factor TS; Region: EF_TS; pfam00889 1267754002500 Elongation factor TS; Region: EF_TS; pfam00889 1267754002501 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1267754002502 putative nucleotide binding site [chemical binding]; other site 1267754002503 uridine monophosphate binding site [chemical binding]; other site 1267754002504 homohexameric interface [polypeptide binding]; other site 1267754002505 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1267754002506 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1267754002507 hinge region; other site 1267754002508 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1267754002509 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1267754002510 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1267754002511 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1267754002512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1267754002513 FeS/SAM binding site; other site 1267754002514 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1267754002515 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1267754002516 putative [Fe4-S4] binding site [ion binding]; other site 1267754002517 putative molybdopterin cofactor binding site [chemical binding]; other site 1267754002518 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1267754002519 putative molybdopterin cofactor binding site; other site 1267754002520 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1267754002521 4Fe-4S binding domain; Region: Fer4; pfam00037 1267754002522 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1267754002523 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 1267754002524 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 1267754002525 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 1267754002526 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1267754002527 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1267754002528 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1267754002529 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1267754002530 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1267754002531 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1267754002532 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1267754002533 active site 1267754002534 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1267754002535 protein binding site [polypeptide binding]; other site 1267754002536 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1267754002537 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1267754002538 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1267754002539 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1267754002540 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1267754002541 Walker A/P-loop; other site 1267754002542 ATP binding site [chemical binding]; other site 1267754002543 Q-loop/lid; other site 1267754002544 ABC transporter signature motif; other site 1267754002545 Walker B; other site 1267754002546 D-loop; other site 1267754002547 H-loop/switch region; other site 1267754002548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1267754002549 Histidine kinase; Region: HisKA_3; pfam07730 1267754002550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754002551 ATP binding site [chemical binding]; other site 1267754002552 Mg2+ binding site [ion binding]; other site 1267754002553 G-X-G motif; other site 1267754002554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1267754002555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754002556 active site 1267754002557 phosphorylation site [posttranslational modification] 1267754002558 intermolecular recognition site; other site 1267754002559 dimerization interface [polypeptide binding]; other site 1267754002560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1267754002561 DNA binding residues [nucleotide binding] 1267754002562 dimerization interface [polypeptide binding]; other site 1267754002563 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1267754002564 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1267754002565 methionine aminopeptidase; Provisional; Region: PRK12318 1267754002566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1267754002567 active site 1267754002568 mycothione reductase; Reviewed; Region: PRK07846 1267754002569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1267754002570 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1267754002571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1267754002572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1267754002573 malate:quinone oxidoreductase; Validated; Region: PRK05257 1267754002574 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1267754002575 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1267754002576 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1267754002577 homodimer interface [polypeptide binding]; other site 1267754002578 active site 1267754002579 SAM binding site [chemical binding]; other site 1267754002580 Protein of unknown function (DUF328); Region: DUF328; cl01143 1267754002581 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1267754002582 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1267754002583 dimer interface [polypeptide binding]; other site 1267754002584 motif 1; other site 1267754002585 active site 1267754002586 motif 2; other site 1267754002587 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1267754002588 putative deacylase active site [active] 1267754002589 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1267754002590 active site 1267754002591 motif 3; other site 1267754002592 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1267754002593 anticodon binding site; other site 1267754002594 Sm and related proteins; Region: Sm_like; cl00259 1267754002595 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1267754002596 NusA N-terminal domain; Region: NusA_N; pfam08529 1267754002597 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1267754002598 RNA binding site [nucleotide binding]; other site 1267754002599 homodimer interface [polypeptide binding]; other site 1267754002600 NusA-like KH domain; Region: KH_5; pfam13184 1267754002601 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1267754002602 G-X-X-G motif; other site 1267754002603 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1267754002604 putative RNA binding cleft [nucleotide binding]; other site 1267754002605 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1267754002606 translation initiation factor IF-2; Region: IF-2; TIGR00487 1267754002607 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1267754002608 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1267754002609 G1 box; other site 1267754002610 putative GEF interaction site [polypeptide binding]; other site 1267754002611 GTP/Mg2+ binding site [chemical binding]; other site 1267754002612 Switch I region; other site 1267754002613 G2 box; other site 1267754002614 G3 box; other site 1267754002615 Switch II region; other site 1267754002616 G4 box; other site 1267754002617 G5 box; other site 1267754002618 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1267754002619 Translation-initiation factor 2; Region: IF-2; pfam11987 1267754002620 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1267754002621 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1267754002622 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1267754002623 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1267754002624 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1267754002625 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1267754002626 active site 1267754002627 metal binding site [ion binding]; metal-binding site 1267754002628 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1267754002629 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1267754002630 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1267754002631 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1267754002632 RNA binding site [nucleotide binding]; other site 1267754002633 active site 1267754002634 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1267754002635 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1267754002636 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1267754002637 active site 1267754002638 Riboflavin kinase; Region: Flavokinase; pfam01687 1267754002639 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1267754002640 16S/18S rRNA binding site [nucleotide binding]; other site 1267754002641 S13e-L30e interaction site [polypeptide binding]; other site 1267754002642 25S rRNA binding site [nucleotide binding]; other site 1267754002643 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1267754002644 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1267754002645 oligomer interface [polypeptide binding]; other site 1267754002646 RNA binding site [nucleotide binding]; other site 1267754002647 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1267754002648 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1267754002649 RNase E interface [polypeptide binding]; other site 1267754002650 trimer interface [polypeptide binding]; other site 1267754002651 active site 1267754002652 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1267754002653 putative nucleic acid binding region [nucleotide binding]; other site 1267754002654 G-X-X-G motif; other site 1267754002655 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1267754002656 RNA binding site [nucleotide binding]; other site 1267754002657 domain interface; other site 1267754002658 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1267754002659 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1267754002660 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1267754002661 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1267754002662 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1267754002663 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1267754002664 dimer interface [polypeptide binding]; other site 1267754002665 active site 1267754002666 catalytic residue [active] 1267754002667 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1267754002668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1267754002669 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1267754002670 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1267754002671 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1267754002672 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1267754002673 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1267754002674 Integral membrane protein TerC family; Region: TerC; cl10468 1267754002675 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1267754002676 Competence-damaged protein; Region: CinA; pfam02464 1267754002677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1267754002678 non-specific DNA binding site [nucleotide binding]; other site 1267754002679 salt bridge; other site 1267754002680 sequence-specific DNA binding site [nucleotide binding]; other site 1267754002681 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1267754002682 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1267754002683 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1267754002684 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1267754002685 Walker A/P-loop; other site 1267754002686 ATP binding site [chemical binding]; other site 1267754002687 Q-loop/lid; other site 1267754002688 ABC transporter signature motif; other site 1267754002689 Walker B; other site 1267754002690 D-loop; other site 1267754002691 H-loop/switch region; other site 1267754002692 BioY family; Region: BioY; pfam02632 1267754002693 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1267754002694 recombinase A; Provisional; Region: recA; PRK09354 1267754002695 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1267754002696 hexamer interface [polypeptide binding]; other site 1267754002697 Walker A motif; other site 1267754002698 ATP binding site [chemical binding]; other site 1267754002699 Walker B motif; other site 1267754002700 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1267754002701 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1267754002702 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1267754002703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1267754002704 FeS/SAM binding site; other site 1267754002705 TRAM domain; Region: TRAM; cl01282 1267754002706 CoA-binding domain; Region: CoA_binding_3; pfam13727 1267754002707 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1267754002708 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1267754002709 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1267754002710 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1267754002711 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1267754002712 GTPases [General function prediction only]; Region: HflX; COG2262 1267754002713 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1267754002714 HflX GTPase family; Region: HflX; cd01878 1267754002715 G1 box; other site 1267754002716 GTP/Mg2+ binding site [chemical binding]; other site 1267754002717 Switch I region; other site 1267754002718 G2 box; other site 1267754002719 G3 box; other site 1267754002720 Switch II region; other site 1267754002721 G4 box; other site 1267754002722 G5 box; other site 1267754002723 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1267754002724 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1267754002725 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1267754002726 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1267754002727 LexA repressor; Validated; Region: PRK00215 1267754002728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1267754002729 putative DNA binding site [nucleotide binding]; other site 1267754002730 putative Zn2+ binding site [ion binding]; other site 1267754002731 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1267754002732 Catalytic site [active] 1267754002733 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1267754002734 ATP cone domain; Region: ATP-cone; pfam03477 1267754002735 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1267754002736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754002737 ATP binding site [chemical binding]; other site 1267754002738 putative Mg++ binding site [ion binding]; other site 1267754002739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754002740 nucleotide binding region [chemical binding]; other site 1267754002741 ATP-binding site [chemical binding]; other site 1267754002742 Helicase associated domain (HA2); Region: HA2; pfam04408 1267754002743 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1267754002744 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1267754002745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1267754002746 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1267754002747 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1267754002748 dimerization interface [polypeptide binding]; other site 1267754002749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754002750 ATP binding site [chemical binding]; other site 1267754002751 putative Mg++ binding site [ion binding]; other site 1267754002752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754002753 nucleotide binding region [chemical binding]; other site 1267754002754 ATP-binding site [chemical binding]; other site 1267754002755 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1267754002756 PAC2 family; Region: PAC2; pfam09754 1267754002757 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1267754002758 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1267754002759 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1267754002760 NAD binding site [chemical binding]; other site 1267754002761 homodimer interface [polypeptide binding]; other site 1267754002762 active site 1267754002763 substrate binding site [chemical binding]; other site 1267754002764 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1267754002765 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1267754002766 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1267754002767 FeoA domain; Region: FeoA; pfam04023 1267754002768 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1267754002769 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1267754002770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1267754002771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1267754002772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1267754002773 DNA binding residues [nucleotide binding] 1267754002774 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 1267754002775 putative active site [active] 1267754002776 dimerization interface [polypeptide binding]; other site 1267754002777 putative tRNAtyr binding site [nucleotide binding]; other site 1267754002778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754002779 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1267754002780 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1267754002781 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1267754002782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754002783 ATP binding site [chemical binding]; other site 1267754002784 putative Mg++ binding site [ion binding]; other site 1267754002785 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1267754002786 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1267754002787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1267754002788 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1267754002789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1267754002790 DNA binding residues [nucleotide binding] 1267754002791 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1267754002792 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1267754002793 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1267754002794 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1267754002795 active site 1267754002796 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1267754002797 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1267754002798 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1267754002799 trimer interface [polypeptide binding]; other site 1267754002800 active site 1267754002801 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1267754002802 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1267754002803 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1267754002804 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1267754002805 TPP-binding site; other site 1267754002806 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1267754002807 PYR/PP interface [polypeptide binding]; other site 1267754002808 dimer interface [polypeptide binding]; other site 1267754002809 TPP binding site [chemical binding]; other site 1267754002810 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1267754002811 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1267754002812 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1267754002813 putative ligand binding residues [chemical binding]; other site 1267754002814 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754002815 ABC-ATPase subunit interface; other site 1267754002816 dimer interface [polypeptide binding]; other site 1267754002817 putative PBP binding regions; other site 1267754002818 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1267754002819 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754002820 ABC-ATPase subunit interface; other site 1267754002821 dimer interface [polypeptide binding]; other site 1267754002822 putative PBP binding regions; other site 1267754002823 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1267754002824 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754002825 Walker A/P-loop; other site 1267754002826 ATP binding site [chemical binding]; other site 1267754002827 Q-loop/lid; other site 1267754002828 ABC transporter signature motif; other site 1267754002829 Walker B; other site 1267754002830 D-loop; other site 1267754002831 H-loop/switch region; other site 1267754002832 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1267754002833 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1267754002834 substrate binding site [chemical binding]; other site 1267754002835 active site 1267754002836 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1267754002837 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1267754002838 SelR domain; Region: SelR; pfam01641 1267754002839 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1267754002840 CopC domain; Region: CopC; pfam04234 1267754002841 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1267754002842 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1267754002843 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1267754002844 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1267754002845 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1267754002846 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1267754002847 active site 1267754002848 dimer interface [polypeptide binding]; other site 1267754002849 motif 1; other site 1267754002850 motif 2; other site 1267754002851 motif 3; other site 1267754002852 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1267754002853 anticodon binding site; other site 1267754002854 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1267754002855 nucleotide binding site/active site [active] 1267754002856 HIT family signature motif; other site 1267754002857 catalytic residue [active] 1267754002858 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1267754002859 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1267754002860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1267754002861 putative acyl-acceptor binding pocket; other site 1267754002862 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1267754002863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1267754002864 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1267754002865 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1267754002866 active site 1267754002867 multimer interface [polypeptide binding]; other site 1267754002868 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1267754002869 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1267754002870 active site 1267754002871 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1267754002872 catalytic triad [active] 1267754002873 dimer interface [polypeptide binding]; other site 1267754002874 hypothetical protein; Validated; Region: PRK00110 1267754002875 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1267754002876 active site 1267754002877 putative DNA-binding cleft [nucleotide binding]; other site 1267754002878 dimer interface [polypeptide binding]; other site 1267754002879 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1267754002880 RuvA N terminal domain; Region: RuvA_N; pfam01330 1267754002881 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1267754002882 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1267754002883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754002884 Walker A motif; other site 1267754002885 ATP binding site [chemical binding]; other site 1267754002886 Walker B motif; other site 1267754002887 arginine finger; other site 1267754002888 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1267754002889 Preprotein translocase subunit; Region: YajC; pfam02699 1267754002890 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1267754002891 Protein export membrane protein; Region: SecD_SecF; cl14618 1267754002892 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1267754002893 Protein export membrane protein; Region: SecD_SecF; pfam02355 1267754002894 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1267754002895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754002896 active site 1267754002897 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1267754002898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1267754002899 Zn2+ binding site [ion binding]; other site 1267754002900 Mg2+ binding site [ion binding]; other site 1267754002901 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1267754002902 synthetase active site [active] 1267754002903 NTP binding site [chemical binding]; other site 1267754002904 metal binding site [ion binding]; metal-binding site 1267754002905 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1267754002906 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1267754002907 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1267754002908 active site 1267754002909 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1267754002910 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1267754002911 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1267754002912 dimer interface [polypeptide binding]; other site 1267754002913 motif 1; other site 1267754002914 active site 1267754002915 motif 2; other site 1267754002916 motif 3; other site 1267754002917 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1267754002918 anticodon binding site; other site 1267754002919 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1267754002920 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1267754002921 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1267754002922 dimer interface [polypeptide binding]; other site 1267754002923 anticodon binding site; other site 1267754002924 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1267754002925 homodimer interface [polypeptide binding]; other site 1267754002926 motif 1; other site 1267754002927 active site 1267754002928 motif 2; other site 1267754002929 GAD domain; Region: GAD; pfam02938 1267754002930 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1267754002931 active site 1267754002932 motif 3; other site 1267754002933 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1267754002934 substrate binding site [chemical binding]; other site 1267754002935 recombination factor protein RarA; Reviewed; Region: PRK13342 1267754002936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754002937 Walker A motif; other site 1267754002938 ATP binding site [chemical binding]; other site 1267754002939 Walker B motif; other site 1267754002940 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1267754002941 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1267754002942 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1267754002943 motif 1; other site 1267754002944 active site 1267754002945 motif 2; other site 1267754002946 motif 3; other site 1267754002947 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1267754002948 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1267754002949 YceG-like family; Region: YceG; pfam02618 1267754002950 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1267754002951 dimerization interface [polypeptide binding]; other site 1267754002952 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1267754002953 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1267754002954 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1267754002955 shikimate binding site; other site 1267754002956 NAD(P) binding site [chemical binding]; other site 1267754002957 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1267754002958 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1267754002959 FMN binding site [chemical binding]; other site 1267754002960 active site 1267754002961 substrate binding site [chemical binding]; other site 1267754002962 catalytic residue [active] 1267754002963 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1267754002964 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1267754002965 Tetramer interface [polypeptide binding]; other site 1267754002966 active site 1267754002967 FMN-binding site [chemical binding]; other site 1267754002968 shikimate kinase; Reviewed; Region: aroK; PRK00131 1267754002969 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1267754002970 ADP binding site [chemical binding]; other site 1267754002971 magnesium binding site [ion binding]; other site 1267754002972 putative shikimate binding site; other site 1267754002973 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1267754002974 active site 1267754002975 dimer interface [polypeptide binding]; other site 1267754002976 metal binding site [ion binding]; metal-binding site 1267754002977 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1267754002978 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1267754002979 trimer interface [polypeptide binding]; other site 1267754002980 active site 1267754002981 dimer interface [polypeptide binding]; other site 1267754002982 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1267754002983 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1267754002984 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1267754002985 active site 1267754002986 elongation factor P; Validated; Region: PRK00529 1267754002987 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1267754002988 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1267754002989 RNA binding site [nucleotide binding]; other site 1267754002990 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1267754002991 RNA binding site [nucleotide binding]; other site 1267754002992 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1267754002993 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1267754002994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754002995 active site 1267754002996 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1267754002997 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1267754002998 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1267754002999 dihydroorotase; Validated; Region: pyrC; PRK09357 1267754003000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1267754003001 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1267754003002 active site 1267754003003 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1267754003004 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1267754003005 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1267754003006 catalytic site [active] 1267754003007 subunit interface [polypeptide binding]; other site 1267754003008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1267754003009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1267754003010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1267754003011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1267754003012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1267754003013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1267754003014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1267754003015 IMP binding site; other site 1267754003016 dimer interface [polypeptide binding]; other site 1267754003017 interdomain contacts; other site 1267754003018 partial ornithine binding site; other site 1267754003019 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1267754003020 active site 1267754003021 dimer interface [polypeptide binding]; other site 1267754003022 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1267754003023 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1267754003024 catalytic site [active] 1267754003025 G-X2-G-X-G-K; other site 1267754003026 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1267754003027 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1267754003028 Flavoprotein; Region: Flavoprotein; pfam02441 1267754003029 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1267754003030 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1267754003031 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1267754003032 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1267754003033 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1267754003034 primosome assembly protein PriA; Provisional; Region: PRK14873 1267754003035 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1267754003036 active site 1267754003037 catalytic residues [active] 1267754003038 metal binding site [ion binding]; metal-binding site 1267754003039 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1267754003040 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1267754003041 putative active site [active] 1267754003042 substrate binding site [chemical binding]; other site 1267754003043 putative cosubstrate binding site; other site 1267754003044 catalytic site [active] 1267754003045 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1267754003046 substrate binding site [chemical binding]; other site 1267754003047 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1267754003048 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1267754003049 putative RNA binding site [nucleotide binding]; other site 1267754003050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754003051 S-adenosylmethionine binding site [chemical binding]; other site 1267754003052 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1267754003053 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1267754003054 substrate binding site [chemical binding]; other site 1267754003055 hexamer interface [polypeptide binding]; other site 1267754003056 metal binding site [ion binding]; metal-binding site 1267754003057 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1267754003058 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1267754003059 catalytic motif [active] 1267754003060 Zn binding site [ion binding]; other site 1267754003061 RibD C-terminal domain; Region: RibD_C; pfam01872 1267754003062 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1267754003063 Lumazine binding domain; Region: Lum_binding; pfam00677 1267754003064 Lumazine binding domain; Region: Lum_binding; pfam00677 1267754003065 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1267754003066 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1267754003067 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1267754003068 dimerization interface [polypeptide binding]; other site 1267754003069 active site 1267754003070 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1267754003071 homopentamer interface [polypeptide binding]; other site 1267754003072 active site 1267754003073 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1267754003074 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 1267754003075 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1267754003076 GIY-YIG motif/motif A; other site 1267754003077 active site 1267754003078 catalytic site [active] 1267754003079 putative DNA binding site [nucleotide binding]; other site 1267754003080 metal binding site [ion binding]; metal-binding site 1267754003081 UvrB/uvrC motif; Region: UVR; pfam02151 1267754003082 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1267754003083 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1267754003084 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1267754003085 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1267754003086 phosphate binding site [ion binding]; other site 1267754003087 putative substrate binding pocket [chemical binding]; other site 1267754003088 dimer interface [polypeptide binding]; other site 1267754003089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1267754003090 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1267754003091 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1267754003092 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1267754003093 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1267754003094 Phosphoglycerate kinase; Region: PGK; pfam00162 1267754003095 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1267754003096 substrate binding site [chemical binding]; other site 1267754003097 hinge regions; other site 1267754003098 ADP binding site [chemical binding]; other site 1267754003099 catalytic site [active] 1267754003100 triosephosphate isomerase; Provisional; Region: PRK14567 1267754003101 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1267754003102 substrate binding site [chemical binding]; other site 1267754003103 dimer interface [polypeptide binding]; other site 1267754003104 catalytic triad [active] 1267754003105 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1267754003106 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1267754003107 putative active site [active] 1267754003108 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1267754003109 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1267754003110 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1267754003111 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1267754003112 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1267754003113 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1267754003114 putative active site [active] 1267754003115 transaldolase; Provisional; Region: PRK03903 1267754003116 catalytic residue [active] 1267754003117 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1267754003118 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1267754003119 TPP-binding site [chemical binding]; other site 1267754003120 dimer interface [polypeptide binding]; other site 1267754003121 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1267754003122 PYR/PP interface [polypeptide binding]; other site 1267754003123 dimer interface [polypeptide binding]; other site 1267754003124 TPP binding site [chemical binding]; other site 1267754003125 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1267754003126 UbiA prenyltransferase family; Region: UbiA; pfam01040 1267754003127 SdpI/YhfL protein family; Region: SdpI; pfam13630 1267754003128 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1267754003129 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1267754003130 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1267754003131 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1267754003132 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1267754003133 Walker A/P-loop; other site 1267754003134 ATP binding site [chemical binding]; other site 1267754003135 Q-loop/lid; other site 1267754003136 ABC transporter signature motif; other site 1267754003137 Walker B; other site 1267754003138 D-loop; other site 1267754003139 H-loop/switch region; other site 1267754003140 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1267754003141 Predicted transcriptional regulator [Transcription]; Region: COG2345 1267754003142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1267754003143 dimerization interface [polypeptide binding]; other site 1267754003144 putative DNA binding site [nucleotide binding]; other site 1267754003145 putative Zn2+ binding site [ion binding]; other site 1267754003146 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1267754003147 FeS assembly protein SufB; Region: sufB; TIGR01980 1267754003148 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1267754003149 FeS assembly protein SufD; Region: sufD; TIGR01981 1267754003150 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1267754003151 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1267754003152 Walker A/P-loop; other site 1267754003153 ATP binding site [chemical binding]; other site 1267754003154 Q-loop/lid; other site 1267754003155 ABC transporter signature motif; other site 1267754003156 Walker B; other site 1267754003157 D-loop; other site 1267754003158 H-loop/switch region; other site 1267754003159 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1267754003160 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1267754003161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754003162 catalytic residue [active] 1267754003163 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1267754003164 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1267754003165 trimerization site [polypeptide binding]; other site 1267754003166 active site 1267754003167 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1267754003168 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1267754003169 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1267754003170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1267754003171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754003172 Walker A/P-loop; other site 1267754003173 ATP binding site [chemical binding]; other site 1267754003174 Q-loop/lid; other site 1267754003175 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1267754003176 ABC transporter signature motif; other site 1267754003177 Walker B; other site 1267754003178 ABC transporter; Region: ABC_tran_2; pfam12848 1267754003179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1267754003180 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1267754003181 hypothetical protein; Validated; Region: PRK00194 1267754003182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754003183 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1267754003184 NAD(P) binding site [chemical binding]; other site 1267754003185 active site 1267754003186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754003187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754003188 aconitate hydratase; Validated; Region: PRK09277 1267754003189 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1267754003190 substrate binding site [chemical binding]; other site 1267754003191 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1267754003192 ligand binding site [chemical binding]; other site 1267754003193 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1267754003194 substrate binding site [chemical binding]; other site 1267754003195 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1267754003196 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1267754003197 NlpC/P60 family; Region: NLPC_P60; pfam00877 1267754003198 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1267754003199 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1267754003200 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1267754003201 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1267754003202 substrate binding site [chemical binding]; other site 1267754003203 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1267754003204 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1267754003205 quinone interaction residues [chemical binding]; other site 1267754003206 active site 1267754003207 catalytic residues [active] 1267754003208 FMN binding site [chemical binding]; other site 1267754003209 substrate binding site [chemical binding]; other site 1267754003210 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1267754003211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1267754003212 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1267754003213 active site 1267754003214 HIGH motif; other site 1267754003215 nucleotide binding site [chemical binding]; other site 1267754003216 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1267754003217 active site 1267754003218 KMSKS motif; other site 1267754003219 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1267754003220 tRNA binding surface [nucleotide binding]; other site 1267754003221 anticodon binding site; other site 1267754003222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1267754003223 homodimer interface [polypeptide binding]; other site 1267754003224 putative metal binding site [ion binding]; other site 1267754003225 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1267754003226 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1267754003227 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1267754003228 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1267754003229 Aspartase; Region: Aspartase; cd01357 1267754003230 active sites [active] 1267754003231 tetramer interface [polypeptide binding]; other site 1267754003232 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1267754003233 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1267754003234 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1267754003235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754003236 S-adenosylmethionine binding site [chemical binding]; other site 1267754003237 proteasome ATPase; Region: pup_AAA; TIGR03689 1267754003238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754003239 Walker A motif; other site 1267754003240 ATP binding site [chemical binding]; other site 1267754003241 Walker B motif; other site 1267754003242 arginine finger; other site 1267754003243 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1267754003244 Pup-like protein; Region: Pup; pfam05639 1267754003245 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1267754003246 WYL domain; Region: WYL; pfam13280 1267754003247 Predicted transcriptional regulator [Transcription]; Region: COG2378 1267754003248 WYL domain; Region: WYL; pfam13280 1267754003249 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1267754003250 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1267754003251 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1267754003252 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1267754003253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754003254 ATP binding site [chemical binding]; other site 1267754003255 putative Mg++ binding site [ion binding]; other site 1267754003256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754003257 nucleotide binding region [chemical binding]; other site 1267754003258 ATP-binding site [chemical binding]; other site 1267754003259 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1267754003260 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1267754003261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754003262 NAD(P) binding site [chemical binding]; other site 1267754003263 active site 1267754003264 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1267754003265 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1267754003266 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1267754003267 putative active site [active] 1267754003268 catalytic triad [active] 1267754003269 putative dimer interface [polypeptide binding]; other site 1267754003270 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1267754003271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1267754003272 Ligand binding site; other site 1267754003273 Putative Catalytic site; other site 1267754003274 DXD motif; other site 1267754003275 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1267754003276 YceI-like domain; Region: YceI; pfam04264 1267754003277 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1267754003278 MgtE intracellular N domain; Region: MgtE_N; smart00924 1267754003279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1267754003280 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1267754003281 Divalent cation transporter; Region: MgtE; pfam01769 1267754003282 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1267754003283 TrkA-N domain; Region: TrkA_N; pfam02254 1267754003284 TrkA-C domain; Region: TrkA_C; pfam02080 1267754003285 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1267754003286 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1267754003287 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1267754003288 amidase; Provisional; Region: PRK12470 1267754003289 Amidase; Region: Amidase; cl11426 1267754003290 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1267754003291 FAD binding domain; Region: FAD_binding_2; pfam00890 1267754003292 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1267754003293 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1267754003294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1267754003295 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1267754003296 CoenzymeA binding site [chemical binding]; other site 1267754003297 subunit interaction site [polypeptide binding]; other site 1267754003298 PHB binding site; other site 1267754003299 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1267754003300 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1267754003301 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1267754003302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1267754003303 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1267754003304 ATP binding site [chemical binding]; other site 1267754003305 putative Mg++ binding site [ion binding]; other site 1267754003306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754003307 nucleotide binding region [chemical binding]; other site 1267754003308 ATP-binding site [chemical binding]; other site 1267754003309 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1267754003310 Domain of unknown function DUF21; Region: DUF21; pfam01595 1267754003311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1267754003312 Transporter associated domain; Region: CorC_HlyC; smart01091 1267754003313 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1267754003314 Domain of unknown function DUF21; Region: DUF21; pfam01595 1267754003315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1267754003316 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1267754003317 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1267754003318 DNA binding residues [nucleotide binding] 1267754003319 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1267754003320 putative dimer interface [polypeptide binding]; other site 1267754003321 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1267754003322 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1267754003323 DNA binding residues [nucleotide binding] 1267754003324 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1267754003325 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1267754003326 phosphopeptide binding site; other site 1267754003327 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1267754003328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1267754003329 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1267754003330 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1267754003331 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1267754003332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754003333 ATP binding site [chemical binding]; other site 1267754003334 putative Mg++ binding site [ion binding]; other site 1267754003335 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1267754003336 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1267754003337 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1267754003338 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1267754003339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754003340 S-adenosylmethionine binding site [chemical binding]; other site 1267754003341 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1267754003342 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1267754003343 Walker A/P-loop; other site 1267754003344 ATP binding site [chemical binding]; other site 1267754003345 Q-loop/lid; other site 1267754003346 ABC transporter signature motif; other site 1267754003347 Walker B; other site 1267754003348 D-loop; other site 1267754003349 H-loop/switch region; other site 1267754003350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1267754003351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754003352 active site 1267754003353 phosphorylation site [posttranslational modification] 1267754003354 intermolecular recognition site; other site 1267754003355 dimerization interface [polypeptide binding]; other site 1267754003356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1267754003357 DNA binding residues [nucleotide binding] 1267754003358 dimerization interface [polypeptide binding]; other site 1267754003359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1267754003360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1267754003361 non-specific DNA binding site [nucleotide binding]; other site 1267754003362 salt bridge; other site 1267754003363 sequence-specific DNA binding site [nucleotide binding]; other site 1267754003364 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1267754003365 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1267754003366 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1267754003367 TrkA-N domain; Region: TrkA_N; pfam02254 1267754003368 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 1267754003369 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1267754003370 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1267754003371 Potassium binding sites [ion binding]; other site 1267754003372 Cesium cation binding sites [ion binding]; other site 1267754003373 Haemolysin-III related; Region: HlyIII; pfam03006 1267754003374 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1267754003375 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1267754003376 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1267754003377 CMP-binding site; other site 1267754003378 The sites determining sugar specificity; other site 1267754003379 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1267754003380 G1 box; other site 1267754003381 GTP/Mg2+ binding site [chemical binding]; other site 1267754003382 Switch I region; other site 1267754003383 G2 box; other site 1267754003384 Switch II region; other site 1267754003385 G3 box; other site 1267754003386 G4 box; other site 1267754003387 G5 box; other site 1267754003388 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1267754003389 G1 box; other site 1267754003390 GTP/Mg2+ binding site [chemical binding]; other site 1267754003391 Switch I region; other site 1267754003392 G2 box; other site 1267754003393 G3 box; other site 1267754003394 Switch II region; other site 1267754003395 G4 box; other site 1267754003396 G5 box; other site 1267754003397 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1267754003398 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1267754003399 RNA binding surface [nucleotide binding]; other site 1267754003400 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1267754003401 active site 1267754003402 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1267754003403 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1267754003404 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1267754003405 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1267754003406 P-loop; other site 1267754003407 Magnesium ion binding site [ion binding]; other site 1267754003408 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1267754003409 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1267754003410 active site 1267754003411 DNA binding site [nucleotide binding] 1267754003412 Int/Topo IB signature motif; other site 1267754003413 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1267754003414 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1267754003415 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1267754003416 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1267754003417 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1267754003418 Walker A/P-loop; other site 1267754003419 ATP binding site [chemical binding]; other site 1267754003420 Q-loop/lid; other site 1267754003421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754003422 Walker B; other site 1267754003423 D-loop; other site 1267754003424 H-loop/switch region; other site 1267754003425 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1267754003426 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1267754003427 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1267754003428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1267754003429 RNA binding surface [nucleotide binding]; other site 1267754003430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754003431 S-adenosylmethionine binding site [chemical binding]; other site 1267754003432 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1267754003433 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1267754003434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754003435 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1267754003436 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1267754003437 active site 1267754003438 HIGH motif; other site 1267754003439 dimer interface [polypeptide binding]; other site 1267754003440 KMSKS motif; other site 1267754003441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1267754003442 RNA binding surface [nucleotide binding]; other site 1267754003443 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1267754003444 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1267754003445 ThiC-associated domain; Region: ThiC-associated; pfam13667 1267754003446 ThiC family; Region: ThiC; pfam01964 1267754003447 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1267754003448 thiamine phosphate binding site [chemical binding]; other site 1267754003449 active site 1267754003450 pyrophosphate binding site [ion binding]; other site 1267754003451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754003452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754003453 putative substrate translocation pore; other site 1267754003454 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1267754003455 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1267754003456 thiS-thiF/thiG interaction site; other site 1267754003457 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1267754003458 ThiS interaction site; other site 1267754003459 putative active site [active] 1267754003460 tetramer interface [polypeptide binding]; other site 1267754003461 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1267754003462 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1267754003463 ATP binding site [chemical binding]; other site 1267754003464 substrate interface [chemical binding]; other site 1267754003465 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1267754003466 active site residue [active] 1267754003467 argininosuccinate lyase; Provisional; Region: PRK00855 1267754003468 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1267754003469 active sites [active] 1267754003470 tetramer interface [polypeptide binding]; other site 1267754003471 argininosuccinate synthase; Provisional; Region: PRK13820 1267754003472 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1267754003473 ANP binding site [chemical binding]; other site 1267754003474 Substrate Binding Site II [chemical binding]; other site 1267754003475 Substrate Binding Site I [chemical binding]; other site 1267754003476 arginine repressor; Provisional; Region: PRK03341 1267754003477 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1267754003478 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1267754003479 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1267754003480 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1267754003481 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1267754003482 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1267754003483 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1267754003484 inhibitor-cofactor binding pocket; inhibition site 1267754003485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754003486 catalytic residue [active] 1267754003487 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1267754003488 feedback inhibition sensing region; other site 1267754003489 homohexameric interface [polypeptide binding]; other site 1267754003490 nucleotide binding site [chemical binding]; other site 1267754003491 N-acetyl-L-glutamate binding site [chemical binding]; other site 1267754003492 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1267754003493 heterotetramer interface [polypeptide binding]; other site 1267754003494 active site pocket [active] 1267754003495 cleavage site 1267754003496 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1267754003497 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1267754003498 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1267754003499 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1267754003500 putative tRNA-binding site [nucleotide binding]; other site 1267754003501 B3/4 domain; Region: B3_4; pfam03483 1267754003502 tRNA synthetase B5 domain; Region: B5; smart00874 1267754003503 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1267754003504 dimer interface [polypeptide binding]; other site 1267754003505 motif 1; other site 1267754003506 motif 3; other site 1267754003507 motif 2; other site 1267754003508 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1267754003509 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1267754003510 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1267754003511 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1267754003512 dimer interface [polypeptide binding]; other site 1267754003513 motif 1; other site 1267754003514 active site 1267754003515 motif 2; other site 1267754003516 motif 3; other site 1267754003517 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1267754003518 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1267754003519 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1267754003520 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1267754003521 23S rRNA binding site [nucleotide binding]; other site 1267754003522 L21 binding site [polypeptide binding]; other site 1267754003523 L13 binding site [polypeptide binding]; other site 1267754003524 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1267754003525 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1267754003526 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1267754003527 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1267754003528 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1267754003529 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1267754003530 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1267754003531 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1267754003532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1267754003533 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1267754003534 Part of AAA domain; Region: AAA_19; pfam13245 1267754003535 Family description; Region: UvrD_C_2; pfam13538 1267754003536 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1267754003537 Ligand Binding Site [chemical binding]; other site 1267754003538 excinuclease ABC subunit B; Provisional; Region: PRK05298 1267754003539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754003540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754003541 nucleotide binding region [chemical binding]; other site 1267754003542 ATP-binding site [chemical binding]; other site 1267754003543 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1267754003544 UvrB/uvrC motif; Region: UVR; pfam02151 1267754003545 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1267754003546 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1267754003547 CoA-binding site [chemical binding]; other site 1267754003548 ATP-binding [chemical binding]; other site 1267754003549 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1267754003550 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1267754003551 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1267754003552 dimer interface [polypeptide binding]; other site 1267754003553 active site 1267754003554 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1267754003555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754003556 NAD(P) binding site [chemical binding]; other site 1267754003557 active site 1267754003558 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1267754003559 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1267754003560 active site 2 [active] 1267754003561 active site 1 [active] 1267754003562 Predicted membrane protein [Function unknown]; Region: COG2323 1267754003563 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1267754003564 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1267754003565 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1267754003566 RNA binding site [nucleotide binding]; other site 1267754003567 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1267754003568 RNA binding site [nucleotide binding]; other site 1267754003569 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1267754003570 RNA binding site [nucleotide binding]; other site 1267754003571 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1267754003572 RNA binding site [nucleotide binding]; other site 1267754003573 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1267754003574 DNA polymerase I; Provisional; Region: PRK05755 1267754003575 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1267754003576 active site 1267754003577 metal binding site 1 [ion binding]; metal-binding site 1267754003578 putative 5' ssDNA interaction site; other site 1267754003579 metal binding site 3; metal-binding site 1267754003580 metal binding site 2 [ion binding]; metal-binding site 1267754003581 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1267754003582 putative DNA binding site [nucleotide binding]; other site 1267754003583 putative metal binding site [ion binding]; other site 1267754003584 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1267754003585 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1267754003586 active site 1267754003587 DNA binding site [nucleotide binding] 1267754003588 catalytic site [active] 1267754003589 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1267754003590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1267754003591 ABC-ATPase subunit interface; other site 1267754003592 dimer interface [polypeptide binding]; other site 1267754003593 putative PBP binding regions; other site 1267754003594 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1267754003595 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1267754003596 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1267754003597 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754003598 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1267754003599 intersubunit interface [polypeptide binding]; other site 1267754003600 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1267754003601 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1267754003602 NAD(P) binding site [chemical binding]; other site 1267754003603 substrate binding site [chemical binding]; other site 1267754003604 dimer interface [polypeptide binding]; other site 1267754003605 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1267754003606 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1267754003607 G1 box; other site 1267754003608 GTP/Mg2+ binding site [chemical binding]; other site 1267754003609 G2 box; other site 1267754003610 Switch I region; other site 1267754003611 G3 box; other site 1267754003612 Switch II region; other site 1267754003613 G4 box; other site 1267754003614 Nucleoside recognition; Region: Gate; pfam07670 1267754003615 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1267754003616 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1267754003617 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1267754003618 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1267754003619 glutaminase; Provisional; Region: PRK00971 1267754003620 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1267754003621 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1267754003622 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1267754003623 DNA binding site [nucleotide binding] 1267754003624 active site 1267754003625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1267754003626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1267754003627 substrate binding pocket [chemical binding]; other site 1267754003628 membrane-bound complex binding site; other site 1267754003629 hinge residues; other site 1267754003630 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1267754003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754003632 dimer interface [polypeptide binding]; other site 1267754003633 conserved gate region; other site 1267754003634 putative PBP binding loops; other site 1267754003635 ABC-ATPase subunit interface; other site 1267754003636 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1267754003637 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1267754003638 Walker A/P-loop; other site 1267754003639 ATP binding site [chemical binding]; other site 1267754003640 Q-loop/lid; other site 1267754003641 ABC transporter signature motif; other site 1267754003642 Walker B; other site 1267754003643 D-loop; other site 1267754003644 H-loop/switch region; other site 1267754003645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1267754003646 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1267754003647 nucleotide binding site/active site [active] 1267754003648 HIT family signature motif; other site 1267754003649 catalytic residue [active] 1267754003650 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1267754003651 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1267754003652 metal binding site [ion binding]; metal-binding site 1267754003653 putative dimer interface [polypeptide binding]; other site 1267754003654 pyruvate kinase; Provisional; Region: PRK06247 1267754003655 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1267754003656 active site 1267754003657 domain interfaces; other site 1267754003658 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1267754003659 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1267754003660 substrate binding site [chemical binding]; other site 1267754003661 active site 1267754003662 catalytic residues [active] 1267754003663 heterodimer interface [polypeptide binding]; other site 1267754003664 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1267754003665 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1267754003666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754003667 catalytic residue [active] 1267754003668 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1267754003669 active site 1267754003670 ribulose/triose binding site [chemical binding]; other site 1267754003671 phosphate binding site [ion binding]; other site 1267754003672 substrate (anthranilate) binding pocket [chemical binding]; other site 1267754003673 product (indole) binding pocket [chemical binding]; other site 1267754003674 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1267754003675 anthranilate synthase component I; Provisional; Region: PRK13571 1267754003676 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1267754003677 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1267754003678 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1267754003679 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1267754003680 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1267754003681 substrate binding site [chemical binding]; other site 1267754003682 glutamase interaction surface [polypeptide binding]; other site 1267754003683 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1267754003684 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1267754003685 active site 1267754003686 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1267754003687 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1267754003688 catalytic residues [active] 1267754003689 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1267754003690 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1267754003691 putative active site [active] 1267754003692 oxyanion strand; other site 1267754003693 catalytic triad [active] 1267754003694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754003695 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1267754003696 putative active site pocket [active] 1267754003697 4-fold oligomerization interface [polypeptide binding]; other site 1267754003698 metal binding residues [ion binding]; metal-binding site 1267754003699 3-fold/trimer interface [polypeptide binding]; other site 1267754003700 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1267754003701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1267754003702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754003703 homodimer interface [polypeptide binding]; other site 1267754003704 catalytic residue [active] 1267754003705 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1267754003706 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1267754003707 NAD binding site [chemical binding]; other site 1267754003708 dimerization interface [polypeptide binding]; other site 1267754003709 product binding site; other site 1267754003710 substrate binding site [chemical binding]; other site 1267754003711 zinc binding site [ion binding]; other site 1267754003712 catalytic residues [active] 1267754003713 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1267754003714 Dimer interface [polypeptide binding]; other site 1267754003715 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1267754003716 synthetase active site [active] 1267754003717 NTP binding site [chemical binding]; other site 1267754003718 metal binding site [ion binding]; metal-binding site 1267754003719 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1267754003720 RNA binding surface [nucleotide binding]; other site 1267754003721 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1267754003722 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1267754003723 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1267754003724 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1267754003725 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1267754003726 active site 1267754003727 PHP Thumb interface [polypeptide binding]; other site 1267754003728 metal binding site [ion binding]; metal-binding site 1267754003729 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1267754003730 generic binding surface II; other site 1267754003731 generic binding surface I; other site 1267754003732 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1267754003733 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1267754003734 dimer interface [polypeptide binding]; other site 1267754003735 active site 1267754003736 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1267754003737 substrate binding site [chemical binding]; other site 1267754003738 catalytic residue [active] 1267754003739 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1267754003740 EamA-like transporter family; Region: EamA; pfam00892 1267754003741 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1267754003742 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1267754003743 active site 1267754003744 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1267754003745 DNA polymerase IV; Provisional; Region: PRK03348 1267754003746 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1267754003747 active site 1267754003748 DNA binding site [nucleotide binding] 1267754003749 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1267754003750 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1267754003751 HIGH motif; other site 1267754003752 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1267754003753 active site 1267754003754 KMSKS motif; other site 1267754003755 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1267754003756 tRNA binding surface [nucleotide binding]; other site 1267754003757 anticodon binding site; other site 1267754003758 DivIVA domain; Region: DivI1A_domain; TIGR03544 1267754003759 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1267754003760 YGGT family; Region: YGGT; pfam02325 1267754003761 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1267754003762 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1267754003763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1267754003764 catalytic residue [active] 1267754003765 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1267754003766 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1267754003767 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1267754003768 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1267754003769 nucleotide binding site [chemical binding]; other site 1267754003770 SulA interaction site; other site 1267754003771 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1267754003772 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1267754003773 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1267754003774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1267754003775 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1267754003776 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1267754003777 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1267754003778 active site 1267754003779 homodimer interface [polypeptide binding]; other site 1267754003780 cell division protein FtsW; Region: ftsW; TIGR02614 1267754003781 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1267754003782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1267754003783 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1267754003784 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1267754003785 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1267754003786 Mg++ binding site [ion binding]; other site 1267754003787 putative catalytic motif [active] 1267754003788 putative substrate binding site [chemical binding]; other site 1267754003789 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1267754003790 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1267754003791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1267754003792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1267754003793 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1267754003794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1267754003795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1267754003796 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1267754003797 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1267754003798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1267754003799 MraW methylase family; Region: Methyltransf_5; cl17771 1267754003800 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1267754003801 cell division protein MraZ; Reviewed; Region: PRK00326 1267754003802 MraZ protein; Region: MraZ; pfam02381 1267754003803 MraZ protein; Region: MraZ; pfam02381 1267754003804 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1267754003805 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1267754003806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1267754003807 Coenzyme A binding pocket [chemical binding]; other site 1267754003808 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1267754003809 FAD binding site [chemical binding]; other site 1267754003810 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1267754003811 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1267754003812 substrate binding pocket [chemical binding]; other site 1267754003813 chain length determination region; other site 1267754003814 substrate-Mg2+ binding site; other site 1267754003815 catalytic residues [active] 1267754003816 aspartate-rich region 1; other site 1267754003817 active site lid residues [active] 1267754003818 aspartate-rich region 2; other site 1267754003819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1267754003820 phytoene desaturase; Region: crtI_fam; TIGR02734 1267754003821 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1267754003822 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1267754003823 Helix-turn-helix domain; Region: HTH_17; pfam12728 1267754003824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1267754003825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1267754003826 active site 1267754003827 ATP binding site [chemical binding]; other site 1267754003828 substrate binding site [chemical binding]; other site 1267754003829 activation loop (A-loop); other site 1267754003830 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754003831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1267754003832 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754003833 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754003834 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754003835 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1267754003836 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1267754003837 Predicted membrane protein [Function unknown]; Region: COG4763 1267754003838 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1267754003839 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1267754003840 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1267754003841 putative acyl-acceptor binding pocket; other site 1267754003842 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1267754003843 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1267754003844 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1267754003845 nucleotide binding site [chemical binding]; other site 1267754003846 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1267754003847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1267754003848 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1267754003849 NlpC/P60 family; Region: NLPC_P60; pfam00877 1267754003850 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1267754003851 NlpC/P60 family; Region: NLPC_P60; pfam00877 1267754003852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1267754003853 active site 1267754003854 catalytic site [active] 1267754003855 substrate binding site [chemical binding]; other site 1267754003856 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1267754003857 heme bH binding site [chemical binding]; other site 1267754003858 intrachain domain interface; other site 1267754003859 heme bL binding site [chemical binding]; other site 1267754003860 interchain domain interface [polypeptide binding]; other site 1267754003861 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1267754003862 Qo binding site; other site 1267754003863 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1267754003864 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1267754003865 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1267754003866 iron-sulfur cluster [ion binding]; other site 1267754003867 [2Fe-2S] cluster binding site [ion binding]; other site 1267754003868 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1267754003869 Cytochrome c; Region: Cytochrom_C; pfam00034 1267754003870 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1267754003871 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1267754003872 Subunit I/III interface [polypeptide binding]; other site 1267754003873 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1267754003874 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1267754003875 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1267754003876 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1267754003877 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1267754003878 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1267754003879 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1267754003880 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1267754003881 active site 1267754003882 dimer interface [polypeptide binding]; other site 1267754003883 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1267754003884 Ligand Binding Site [chemical binding]; other site 1267754003885 Molecular Tunnel; other site 1267754003886 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1267754003887 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1267754003888 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 1267754003889 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1267754003890 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1267754003891 homodimer interface [polypeptide binding]; other site 1267754003892 substrate-cofactor binding pocket; other site 1267754003893 catalytic residue [active] 1267754003894 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1267754003895 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1267754003896 interface (dimer of trimers) [polypeptide binding]; other site 1267754003897 Substrate-binding/catalytic site; other site 1267754003898 Zn-binding sites [ion binding]; other site 1267754003899 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1267754003900 E3 interaction surface; other site 1267754003901 lipoyl attachment site [posttranslational modification]; other site 1267754003902 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1267754003903 E3 interaction surface; other site 1267754003904 lipoyl attachment site [posttranslational modification]; other site 1267754003905 e3 binding domain; Region: E3_binding; pfam02817 1267754003906 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1267754003907 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1267754003908 lipoate-protein ligase B; Provisional; Region: PRK14345 1267754003909 lipoyl synthase; Provisional; Region: PRK05481 1267754003910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1267754003911 FeS/SAM binding site; other site 1267754003912 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1267754003913 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1267754003914 RDD family; Region: RDD; pfam06271 1267754003915 glutamine synthetase, type I; Region: GlnA; TIGR00653 1267754003916 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1267754003917 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1267754003918 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1267754003919 heme binding pocket [chemical binding]; other site 1267754003920 heme ligand [chemical binding]; other site 1267754003921 Htaa; Region: HtaA; pfam04213 1267754003922 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1267754003923 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754003924 Walker A/P-loop; other site 1267754003925 ATP binding site [chemical binding]; other site 1267754003926 Q-loop/lid; other site 1267754003927 ABC transporter signature motif; other site 1267754003928 Walker B; other site 1267754003929 D-loop; other site 1267754003930 H-loop/switch region; other site 1267754003931 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1267754003932 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754003933 ABC-ATPase subunit interface; other site 1267754003934 dimer interface [polypeptide binding]; other site 1267754003935 putative PBP binding regions; other site 1267754003936 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1267754003937 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754003938 intersubunit interface [polypeptide binding]; other site 1267754003939 Htaa; Region: HtaA; pfam04213 1267754003940 Htaa; Region: HtaA; pfam04213 1267754003941 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1267754003942 Protein of unknown function DUF262; Region: DUF262; pfam03235 1267754003943 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1267754003944 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1267754003945 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1267754003946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754003947 S-adenosylmethionine binding site [chemical binding]; other site 1267754003948 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1267754003949 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1267754003950 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1267754003951 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1267754003952 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1267754003953 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1267754003954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754003955 ATP binding site [chemical binding]; other site 1267754003956 putative Mg++ binding site [ion binding]; other site 1267754003957 CCC1-related family of proteins; Region: CCC1_like; cl00278 1267754003958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1267754003959 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1267754003960 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1267754003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1267754003962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1267754003963 Walker A/P-loop; other site 1267754003964 ATP binding site [chemical binding]; other site 1267754003965 Q-loop/lid; other site 1267754003966 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1267754003967 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1267754003968 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1267754003969 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1267754003970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754003971 putative substrate translocation pore; other site 1267754003972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754003973 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1267754003974 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1267754003975 ornithine cyclodeaminase; Validated; Region: PRK06199 1267754003976 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1267754003977 glutamine synthetase, type I; Region: GlnA; TIGR00653 1267754003978 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1267754003979 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1267754003980 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1267754003981 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1267754003982 gating phenylalanine in ion channel; other site 1267754003983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754003984 Walker A/P-loop; other site 1267754003985 ATP binding site [chemical binding]; other site 1267754003986 Q-loop/lid; other site 1267754003987 ABC transporter signature motif; other site 1267754003988 Walker B; other site 1267754003989 D-loop; other site 1267754003990 H-loop/switch region; other site 1267754003991 Predicted transcriptional regulators [Transcription]; Region: COG1725 1267754003992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1267754003993 DNA-binding site [nucleotide binding]; DNA binding site 1267754003994 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1267754003995 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1267754003996 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1267754003997 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1267754003998 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1267754003999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754004000 catalytic residue [active] 1267754004001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754004002 Walker A/P-loop; other site 1267754004003 ATP binding site [chemical binding]; other site 1267754004004 Q-loop/lid; other site 1267754004005 ABC transporter signature motif; other site 1267754004006 Walker B; other site 1267754004007 D-loop; other site 1267754004008 H-loop/switch region; other site 1267754004009 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1267754004010 Phosphotransferase enzyme family; Region: APH; pfam01636 1267754004011 VanZ like family; Region: VanZ; cl01971 1267754004012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754004013 D-galactonate transporter; Region: 2A0114; TIGR00893 1267754004014 putative substrate translocation pore; other site 1267754004015 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1267754004016 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1267754004017 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 1267754004018 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1267754004019 metal binding triad; other site 1267754004020 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1267754004021 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1267754004022 metal binding triad; other site 1267754004023 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1267754004024 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1267754004025 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1267754004026 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1267754004027 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1267754004028 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1267754004029 oligomerization interface [polypeptide binding]; other site 1267754004030 active site 1267754004031 metal binding site [ion binding]; metal-binding site 1267754004032 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1267754004033 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1267754004034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754004035 motif II; other site 1267754004036 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1267754004037 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1267754004038 RNA/DNA hybrid binding site [nucleotide binding]; other site 1267754004039 active site 1267754004040 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754004041 catalytic core [active] 1267754004042 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1267754004043 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1267754004044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1267754004045 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1267754004046 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1267754004047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754004048 motif II; other site 1267754004049 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1267754004050 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1267754004051 active site 1267754004052 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1267754004053 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1267754004054 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1267754004055 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1267754004056 dimer interface [polypeptide binding]; other site 1267754004057 TPP-binding site [chemical binding]; other site 1267754004058 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1267754004059 acyl carrier protein; Provisional; Region: acpP; PRK00982 1267754004060 Beta-lactamase; Region: Beta-lactamase; pfam00144 1267754004061 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1267754004062 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1267754004063 BCCT family transporter; Region: BCCT; pfam02028 1267754004064 MULE transposase domain; Region: MULE; pfam10551 1267754004065 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1267754004066 putative homodimer interface [polypeptide binding]; other site 1267754004067 putative homotetramer interface [polypeptide binding]; other site 1267754004068 putative allosteric switch controlling residues; other site 1267754004069 putative metal binding site [ion binding]; other site 1267754004070 putative homodimer-homodimer interface [polypeptide binding]; other site 1267754004071 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1267754004072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1267754004073 metal-binding site [ion binding] 1267754004074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1267754004075 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1267754004076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1267754004077 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1267754004078 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1267754004079 NAD binding site [chemical binding]; other site 1267754004080 catalytic Zn binding site [ion binding]; other site 1267754004081 substrate binding site [chemical binding]; other site 1267754004082 structural Zn binding site [ion binding]; other site 1267754004083 DNA primase; Validated; Region: dnaG; PRK05667 1267754004084 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1267754004085 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1267754004086 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1267754004087 active site 1267754004088 metal binding site [ion binding]; metal-binding site 1267754004089 interdomain interaction site; other site 1267754004090 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1267754004091 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1267754004092 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1267754004093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1267754004094 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1267754004095 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1267754004096 active site 1267754004097 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1267754004098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1267754004099 Zn2+ binding site [ion binding]; other site 1267754004100 Mg2+ binding site [ion binding]; other site 1267754004101 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1267754004102 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1267754004103 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1267754004104 active site 1267754004105 FMN binding site [chemical binding]; other site 1267754004106 substrate binding site [chemical binding]; other site 1267754004107 3Fe-4S cluster binding site [ion binding]; other site 1267754004108 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1267754004109 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1267754004110 motif 1; other site 1267754004111 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1267754004112 active site 1267754004113 motif 2; other site 1267754004114 motif 3; other site 1267754004115 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1267754004116 anticodon binding site; other site 1267754004117 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1267754004118 metal binding site 2 [ion binding]; metal-binding site 1267754004119 putative DNA binding helix; other site 1267754004120 metal binding site 1 [ion binding]; metal-binding site 1267754004121 dimer interface [polypeptide binding]; other site 1267754004122 structural Zn2+ binding site [ion binding]; other site 1267754004123 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1267754004124 diiron binding motif [ion binding]; other site 1267754004125 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1267754004126 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1267754004127 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1267754004128 catalytic residue [active] 1267754004129 putative FPP diphosphate binding site; other site 1267754004130 putative FPP binding hydrophobic cleft; other site 1267754004131 dimer interface [polypeptide binding]; other site 1267754004132 putative IPP diphosphate binding site; other site 1267754004133 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1267754004134 Recombination protein O N terminal; Region: RecO_N; pfam11967 1267754004135 Recombination protein O C terminal; Region: RecO_C; pfam02565 1267754004136 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1267754004137 GTPase Era; Reviewed; Region: era; PRK00089 1267754004138 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1267754004139 G1 box; other site 1267754004140 GTP/Mg2+ binding site [chemical binding]; other site 1267754004141 Switch I region; other site 1267754004142 G2 box; other site 1267754004143 Switch II region; other site 1267754004144 G3 box; other site 1267754004145 G4 box; other site 1267754004146 G5 box; other site 1267754004147 KH domain; Region: KH_2; pfam07650 1267754004148 Domain of unknown function DUF21; Region: DUF21; pfam01595 1267754004149 FOG: CBS domain [General function prediction only]; Region: COG0517 1267754004150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1267754004151 metal-binding heat shock protein; Provisional; Region: PRK00016 1267754004152 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1267754004153 PhoH-like protein; Region: PhoH; pfam02562 1267754004154 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1267754004155 chaperone protein DnaJ; Provisional; Region: PRK14278 1267754004156 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1267754004157 HSP70 interaction site [polypeptide binding]; other site 1267754004158 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1267754004159 Zn binding sites [ion binding]; other site 1267754004160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1267754004161 dimer interface [polypeptide binding]; other site 1267754004162 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1267754004163 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1267754004164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1267754004165 FeS/SAM binding site; other site 1267754004166 HemN C-terminal domain; Region: HemN_C; pfam06969 1267754004167 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1267754004168 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1267754004169 acyl-activating enzyme (AAE) consensus motif; other site 1267754004170 putative AMP binding site [chemical binding]; other site 1267754004171 putative active site [active] 1267754004172 putative CoA binding site [chemical binding]; other site 1267754004173 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1267754004174 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1267754004175 active site 1267754004176 Zn binding site [ion binding]; other site 1267754004177 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1267754004178 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754004179 intersubunit interface [polypeptide binding]; other site 1267754004180 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1267754004181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1267754004182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754004183 homodimer interface [polypeptide binding]; other site 1267754004184 catalytic residue [active] 1267754004185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1267754004186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1267754004187 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1267754004188 Walker A/P-loop; other site 1267754004189 ATP binding site [chemical binding]; other site 1267754004190 Q-loop/lid; other site 1267754004191 ABC transporter signature motif; other site 1267754004192 Walker B; other site 1267754004193 D-loop; other site 1267754004194 H-loop/switch region; other site 1267754004195 CsbD-like; Region: CsbD; pfam05532 1267754004196 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1267754004197 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1267754004198 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1267754004199 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1267754004200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754004201 ATP binding site [chemical binding]; other site 1267754004202 putative Mg++ binding site [ion binding]; other site 1267754004203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754004204 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1267754004205 nucleotide binding region [chemical binding]; other site 1267754004206 ATP-binding site [chemical binding]; other site 1267754004207 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1267754004208 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1267754004209 active site 1267754004210 metal binding site [ion binding]; metal-binding site 1267754004211 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1267754004212 Sodium Bile acid symporter family; Region: SBF; pfam01758 1267754004213 GTP-binding protein LepA; Provisional; Region: PRK05433 1267754004214 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1267754004215 G1 box; other site 1267754004216 putative GEF interaction site [polypeptide binding]; other site 1267754004217 GTP/Mg2+ binding site [chemical binding]; other site 1267754004218 Switch I region; other site 1267754004219 G2 box; other site 1267754004220 G3 box; other site 1267754004221 Switch II region; other site 1267754004222 G4 box; other site 1267754004223 G5 box; other site 1267754004224 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1267754004225 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1267754004226 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1267754004227 PemK-like protein; Region: PemK; pfam02452 1267754004228 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1267754004229 hypothetical protein; Validated; Region: PRK05629 1267754004230 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1267754004231 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1267754004232 Competence protein; Region: Competence; pfam03772 1267754004233 SLBB domain; Region: SLBB; pfam10531 1267754004234 comEA protein; Region: comE; TIGR01259 1267754004235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1267754004236 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1267754004237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754004238 catalytic core [active] 1267754004239 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1267754004240 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1267754004241 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1267754004242 active site 1267754004243 (T/H)XGH motif; other site 1267754004244 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1267754004245 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1267754004246 putative catalytic cysteine [active] 1267754004247 gamma-glutamyl kinase; Provisional; Region: PRK05429 1267754004248 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1267754004249 nucleotide binding site [chemical binding]; other site 1267754004250 homotetrameric interface [polypeptide binding]; other site 1267754004251 putative phosphate binding site [ion binding]; other site 1267754004252 putative allosteric binding site; other site 1267754004253 PUA domain; Region: PUA; pfam01472 1267754004254 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1267754004255 GTP1/OBG; Region: GTP1_OBG; pfam01018 1267754004256 Obg GTPase; Region: Obg; cd01898 1267754004257 G1 box; other site 1267754004258 GTP/Mg2+ binding site [chemical binding]; other site 1267754004259 Switch I region; other site 1267754004260 G2 box; other site 1267754004261 G3 box; other site 1267754004262 Switch II region; other site 1267754004263 G4 box; other site 1267754004264 G5 box; other site 1267754004265 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1267754004266 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1267754004267 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1267754004268 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1267754004269 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1267754004270 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1267754004271 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1267754004272 homodimer interface [polypeptide binding]; other site 1267754004273 oligonucleotide binding site [chemical binding]; other site 1267754004274 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1267754004275 active site 1267754004276 multimer interface [polypeptide binding]; other site 1267754004277 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1267754004278 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1267754004279 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1267754004280 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1267754004281 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1267754004282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1267754004283 active site 1267754004284 HIGH motif; other site 1267754004285 nucleotide binding site [chemical binding]; other site 1267754004286 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1267754004287 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1267754004288 active site 1267754004289 KMSKS motif; other site 1267754004290 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1267754004291 tRNA binding surface [nucleotide binding]; other site 1267754004292 anticodon binding site; other site 1267754004293 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1267754004294 malate dehydrogenase; Provisional; Region: PRK05442 1267754004295 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1267754004296 NAD(P) binding site [chemical binding]; other site 1267754004297 LDH/MDH dimer interface [polypeptide binding]; other site 1267754004298 substrate binding site [chemical binding]; other site 1267754004299 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1267754004300 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1267754004301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754004302 Walker A motif; other site 1267754004303 ATP binding site [chemical binding]; other site 1267754004304 Walker B motif; other site 1267754004305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1267754004306 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1267754004307 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1267754004308 oligomer interface [polypeptide binding]; other site 1267754004309 active site residues [active] 1267754004310 Clp protease; Region: CLP_protease; pfam00574 1267754004311 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1267754004312 oligomer interface [polypeptide binding]; other site 1267754004313 active site residues [active] 1267754004314 trigger factor; Provisional; Region: tig; PRK01490 1267754004315 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1267754004316 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1267754004317 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1267754004318 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1267754004319 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1267754004320 Zn binding site [ion binding]; other site 1267754004321 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1267754004322 apolar tunnel; other site 1267754004323 heme binding site [chemical binding]; other site 1267754004324 dimerization interface [polypeptide binding]; other site 1267754004325 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1267754004326 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1267754004327 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1267754004328 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1267754004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754004330 Walker A/P-loop; other site 1267754004331 ATP binding site [chemical binding]; other site 1267754004332 Q-loop/lid; other site 1267754004333 ABC transporter signature motif; other site 1267754004334 Walker B; other site 1267754004335 D-loop; other site 1267754004336 H-loop/switch region; other site 1267754004337 ABC transporter; Region: ABC_tran_2; pfam12848 1267754004338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1267754004339 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1267754004340 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1267754004341 dimer interface [polypeptide binding]; other site 1267754004342 ssDNA binding site [nucleotide binding]; other site 1267754004343 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1267754004344 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1267754004345 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1267754004346 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1267754004347 active site 1267754004348 DNA binding site [nucleotide binding] 1267754004349 Int/Topo IB signature motif; other site 1267754004350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1267754004351 sequence-specific DNA binding site [nucleotide binding]; other site 1267754004352 salt bridge; other site 1267754004353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1267754004354 non-specific DNA binding site [nucleotide binding]; other site 1267754004355 salt bridge; other site 1267754004356 sequence-specific DNA binding site [nucleotide binding]; other site 1267754004357 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1267754004358 DNA methylase; Region: N6_N4_Mtase; pfam01555 1267754004359 DNA methylase; Region: N6_N4_Mtase; pfam01555 1267754004360 DNA methylase; Region: N6_N4_Mtase; cl17433 1267754004361 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1267754004362 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1267754004363 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1267754004364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1267754004365 DNA binding residues [nucleotide binding] 1267754004366 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1267754004367 classical (c) SDRs; Region: SDR_c; cd05233 1267754004368 NAD(P) binding site [chemical binding]; other site 1267754004369 active site 1267754004370 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1267754004371 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1267754004372 catalytic site [active] 1267754004373 putative active site [active] 1267754004374 putative substrate binding site [chemical binding]; other site 1267754004375 dimer interface [polypeptide binding]; other site 1267754004376 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1267754004377 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1267754004378 metal-binding site [ion binding] 1267754004379 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1267754004380 substrate binding pocket [chemical binding]; other site 1267754004381 substrate-Mg2+ binding site; other site 1267754004382 aspartate-rich region 1; other site 1267754004383 aspartate-rich region 2; other site 1267754004384 Bacterial Ig-like domain; Region: Big_5; pfam13205 1267754004385 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1267754004386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1267754004387 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1267754004388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1267754004389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754004390 active site 1267754004391 phosphorylation site [posttranslational modification] 1267754004392 intermolecular recognition site; other site 1267754004393 dimerization interface [polypeptide binding]; other site 1267754004394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1267754004395 DNA binding site [nucleotide binding] 1267754004396 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1267754004397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1267754004398 dimer interface [polypeptide binding]; other site 1267754004399 phosphorylation site [posttranslational modification] 1267754004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754004401 ATP binding site [chemical binding]; other site 1267754004402 Mg2+ binding site [ion binding]; other site 1267754004403 G-X-G motif; other site 1267754004404 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1267754004405 PhoU domain; Region: PhoU; pfam01895 1267754004406 PhoU domain; Region: PhoU; pfam01895 1267754004407 PBP superfamily domain; Region: PBP_like_2; cl17296 1267754004408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754004409 dimer interface [polypeptide binding]; other site 1267754004410 conserved gate region; other site 1267754004411 putative PBP binding loops; other site 1267754004412 ABC-ATPase subunit interface; other site 1267754004413 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1267754004414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754004415 dimer interface [polypeptide binding]; other site 1267754004416 conserved gate region; other site 1267754004417 putative PBP binding loops; other site 1267754004418 ABC-ATPase subunit interface; other site 1267754004419 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1267754004420 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1267754004421 Walker A/P-loop; other site 1267754004422 ATP binding site [chemical binding]; other site 1267754004423 Q-loop/lid; other site 1267754004424 ABC transporter signature motif; other site 1267754004425 Walker B; other site 1267754004426 D-loop; other site 1267754004427 H-loop/switch region; other site 1267754004428 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1267754004429 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1267754004430 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1267754004431 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1267754004432 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1267754004433 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1267754004434 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1267754004435 catalytic triad [active] 1267754004436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754004437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754004438 HTH-like domain; Region: HTH_21; pfam13276 1267754004439 Integrase core domain; Region: rve; pfam00665 1267754004440 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1267754004441 LGFP repeat; Region: LGFP; pfam08310 1267754004442 LGFP repeat; Region: LGFP; pfam08310 1267754004443 LGFP repeat; Region: LGFP; pfam08310 1267754004444 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754004445 MULE transposase domain; Region: MULE; pfam10551 1267754004446 HTH-like domain; Region: HTH_21; pfam13276 1267754004447 Integrase core domain; Region: rve; pfam00665 1267754004448 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1267754004449 LGFP repeat; Region: LGFP; pfam08310 1267754004450 LGFP repeat; Region: LGFP; pfam08310 1267754004451 LGFP repeat; Region: LGFP; pfam08310 1267754004452 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754004453 MULE transposase domain; Region: MULE; pfam10551 1267754004454 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1267754004455 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1267754004456 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1267754004457 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1267754004458 metal binding site [ion binding]; metal-binding site 1267754004459 putative dimer interface [polypeptide binding]; other site 1267754004460 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1267754004461 active site 1267754004462 dimerization interface [polypeptide binding]; other site 1267754004463 ribonuclease PH; Reviewed; Region: rph; PRK00173 1267754004464 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1267754004465 hexamer interface [polypeptide binding]; other site 1267754004466 active site 1267754004467 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1267754004468 glutamate racemase; Provisional; Region: PRK00865 1267754004469 Rhomboid family; Region: Rhomboid; cl11446 1267754004470 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1267754004471 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1267754004472 cleavage site 1267754004473 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1267754004474 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1267754004475 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1267754004476 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1267754004477 active site 1267754004478 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1267754004479 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1267754004480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1267754004481 putative Mg++ binding site [ion binding]; other site 1267754004482 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1267754004483 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1267754004484 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1267754004485 acyl-activating enzyme (AAE) consensus motif; other site 1267754004486 active site 1267754004487 putative CoA binding site [chemical binding]; other site 1267754004488 AMP binding site [chemical binding]; other site 1267754004489 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1267754004490 dimer interface [polypeptide binding]; other site 1267754004491 putative active site [active] 1267754004492 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1267754004493 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1267754004494 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1267754004495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754004496 motif II; other site 1267754004497 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1267754004498 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1267754004499 D-pathway; other site 1267754004500 Putative ubiquinol binding site [chemical binding]; other site 1267754004501 Low-spin heme (heme b) binding site [chemical binding]; other site 1267754004502 Putative water exit pathway; other site 1267754004503 Binuclear center (heme o3/CuB) [ion binding]; other site 1267754004504 K-pathway; other site 1267754004505 Putative proton exit pathway; other site 1267754004506 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1267754004507 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1267754004508 dimer interface [polypeptide binding]; other site 1267754004509 putative radical transfer pathway; other site 1267754004510 diiron center [ion binding]; other site 1267754004511 tyrosyl radical; other site 1267754004512 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1267754004513 Ferritin-like domain; Region: Ferritin; pfam00210 1267754004514 ferroxidase diiron center [ion binding]; other site 1267754004515 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1267754004516 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1267754004517 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1267754004518 active site 1267754004519 dimer interface [polypeptide binding]; other site 1267754004520 catalytic residues [active] 1267754004521 effector binding site; other site 1267754004522 R2 peptide binding site; other site 1267754004523 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1267754004524 enterobactin exporter EntS; Provisional; Region: PRK10489 1267754004525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754004526 putative substrate translocation pore; other site 1267754004527 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1267754004528 catalytic residues [active] 1267754004529 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1267754004530 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1267754004531 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1267754004532 homodimer interface [polypeptide binding]; other site 1267754004533 NAD binding pocket [chemical binding]; other site 1267754004534 ATP binding pocket [chemical binding]; other site 1267754004535 Mg binding site [ion binding]; other site 1267754004536 active-site loop [active] 1267754004537 Protein of unknown function, DUF393; Region: DUF393; cl01136 1267754004538 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1267754004539 putative active site [active] 1267754004540 redox center [active] 1267754004541 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1267754004542 putative transposase OrfB; Reviewed; Region: PHA02517 1267754004543 HTH-like domain; Region: HTH_21; pfam13276 1267754004544 Integrase core domain; Region: rve; pfam00665 1267754004545 Integrase core domain; Region: rve_2; pfam13333 1267754004546 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1267754004547 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1267754004548 catalytic residues [active] 1267754004549 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1267754004550 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1267754004551 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1267754004552 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1267754004553 SmpB-tmRNA interface; other site 1267754004554 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1267754004555 FtsX-like permease family; Region: FtsX; pfam02687 1267754004556 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1267754004557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754004558 Walker A/P-loop; other site 1267754004559 ATP binding site [chemical binding]; other site 1267754004560 Q-loop/lid; other site 1267754004561 ABC transporter signature motif; other site 1267754004562 Walker B; other site 1267754004563 D-loop; other site 1267754004564 H-loop/switch region; other site 1267754004565 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1267754004566 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1267754004567 Proline dehydrogenase; Region: Pro_dh; cl03282 1267754004568 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1267754004569 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 1267754004570 NAD(P) binding site [chemical binding]; other site 1267754004571 catalytic residues [active] 1267754004572 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1267754004573 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1267754004574 RF-1 domain; Region: RF-1; pfam00472 1267754004575 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1267754004576 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1267754004577 active site 1267754004578 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1267754004579 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1267754004580 active site 1267754004581 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1267754004582 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1267754004583 tetramerization interface [polypeptide binding]; other site 1267754004584 NAD(P) binding site [chemical binding]; other site 1267754004585 catalytic residues [active] 1267754004586 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1267754004587 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1267754004588 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1267754004589 active site 1267754004590 dimer interface [polypeptide binding]; other site 1267754004591 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1267754004592 dimer interface [polypeptide binding]; other site 1267754004593 active site 1267754004594 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1267754004595 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1267754004596 active site 1267754004597 trimer interface [polypeptide binding]; other site 1267754004598 allosteric site; other site 1267754004599 active site lid [active] 1267754004600 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1267754004601 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1267754004602 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1267754004603 ligand binding site [chemical binding]; other site 1267754004604 homodimer interface [polypeptide binding]; other site 1267754004605 NAD(P) binding site [chemical binding]; other site 1267754004606 trimer interface B [polypeptide binding]; other site 1267754004607 trimer interface A [polypeptide binding]; other site 1267754004608 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1267754004609 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1267754004610 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1267754004611 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1267754004612 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1267754004613 putative DNA binding site [nucleotide binding]; other site 1267754004614 catalytic residue [active] 1267754004615 putative H2TH interface [polypeptide binding]; other site 1267754004616 putative catalytic residues [active] 1267754004617 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1267754004618 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1267754004619 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1267754004620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754004621 ATP binding site [chemical binding]; other site 1267754004622 putative Mg++ binding site [ion binding]; other site 1267754004623 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1267754004624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754004625 nucleotide binding region [chemical binding]; other site 1267754004626 ATP-binding site [chemical binding]; other site 1267754004627 DEAD/H associated; Region: DEAD_assoc; pfam08494 1267754004628 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1267754004629 active site 1267754004630 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1267754004631 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1267754004632 dimerization interface [polypeptide binding]; other site 1267754004633 active site 1267754004634 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1267754004635 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1267754004636 folate binding site [chemical binding]; other site 1267754004637 NADP+ binding site [chemical binding]; other site 1267754004638 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1267754004639 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1267754004640 Na binding site [ion binding]; other site 1267754004641 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1267754004642 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1267754004643 FAD binding pocket [chemical binding]; other site 1267754004644 FAD binding motif [chemical binding]; other site 1267754004645 phosphate binding motif [ion binding]; other site 1267754004646 NAD binding pocket [chemical binding]; other site 1267754004647 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1267754004648 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1267754004649 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1267754004650 Integrase core domain; Region: rve; pfam00665 1267754004651 Integrase core domain; Region: rve_3; pfam13683 1267754004652 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1267754004653 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1267754004654 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1267754004655 Integrase core domain; Region: rve; pfam00665 1267754004656 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1267754004657 Phosphotransferase enzyme family; Region: APH; pfam01636 1267754004658 active site 1267754004659 ATP binding site [chemical binding]; other site 1267754004660 antibiotic binding site [chemical binding]; other site 1267754004661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1267754004662 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1267754004663 Integrase core domain; Region: rve; pfam00665 1267754004664 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1267754004665 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1267754004666 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1267754004667 DNA-binding interface [nucleotide binding]; DNA binding site 1267754004668 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1267754004669 Phosphotransferase enzyme family; Region: APH; pfam01636 1267754004670 active site 1267754004671 ATP binding site [chemical binding]; other site 1267754004672 antibiotic binding site [chemical binding]; other site 1267754004673 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1267754004674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754004675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754004676 putative substrate translocation pore; other site 1267754004677 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754004678 MULE transposase domain; Region: MULE; pfam10551 1267754004679 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1267754004680 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1267754004681 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1267754004682 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1267754004683 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1267754004684 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1267754004685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754004686 S-adenosylmethionine binding site [chemical binding]; other site 1267754004687 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1267754004688 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754004689 substrate binding site [chemical binding]; other site 1267754004690 oxyanion hole (OAH) forming residues; other site 1267754004691 trimer interface [polypeptide binding]; other site 1267754004692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1267754004693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1267754004694 active site 1267754004695 catalytic tetrad [active] 1267754004696 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1267754004697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754004698 Walker A/P-loop; other site 1267754004699 ATP binding site [chemical binding]; other site 1267754004700 Q-loop/lid; other site 1267754004701 ABC transporter signature motif; other site 1267754004702 Walker B; other site 1267754004703 D-loop; other site 1267754004704 H-loop/switch region; other site 1267754004705 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1267754004706 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1267754004707 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754004708 Walker A/P-loop; other site 1267754004709 ATP binding site [chemical binding]; other site 1267754004710 Q-loop/lid; other site 1267754004711 ABC transporter signature motif; other site 1267754004712 Walker B; other site 1267754004713 D-loop; other site 1267754004714 H-loop/switch region; other site 1267754004715 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1267754004716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754004717 ABC-ATPase subunit interface; other site 1267754004718 dimer interface [polypeptide binding]; other site 1267754004719 putative PBP binding regions; other site 1267754004720 FecCD transport family; Region: FecCD; pfam01032 1267754004721 putative PBP binding regions; other site 1267754004722 ABC-ATPase subunit interface; other site 1267754004723 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754004724 intersubunit interface [polypeptide binding]; other site 1267754004725 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1267754004726 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1267754004727 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1267754004728 dimer interface [polypeptide binding]; other site 1267754004729 active site 1267754004730 citrylCoA binding site [chemical binding]; other site 1267754004731 NADH binding [chemical binding]; other site 1267754004732 cationic pore residues; other site 1267754004733 oxalacetate/citrate binding site [chemical binding]; other site 1267754004734 coenzyme A binding site [chemical binding]; other site 1267754004735 catalytic triad [active] 1267754004736 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1267754004737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754004738 catalytic residue [active] 1267754004739 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1267754004740 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1267754004741 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1267754004742 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1267754004743 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1267754004744 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1267754004745 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1267754004746 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1267754004747 DNA-binding site [nucleotide binding]; DNA binding site 1267754004748 RNA-binding motif; other site 1267754004749 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1267754004750 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1267754004751 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1267754004752 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1267754004753 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1267754004754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754004755 ATP binding site [chemical binding]; other site 1267754004756 putative Mg++ binding site [ion binding]; other site 1267754004757 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1267754004758 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1267754004759 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1267754004760 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1267754004761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754004762 ATP binding site [chemical binding]; other site 1267754004763 putative Mg++ binding site [ion binding]; other site 1267754004764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1267754004765 nucleotide binding region [chemical binding]; other site 1267754004766 ATP-binding site [chemical binding]; other site 1267754004767 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1267754004768 MarR family; Region: MarR_2; pfam12802 1267754004769 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1267754004770 putative active site [active] 1267754004771 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1267754004772 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1267754004773 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1267754004774 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1267754004775 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1267754004776 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1267754004777 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1267754004778 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1267754004779 carboxyltransferase (CT) interaction site; other site 1267754004780 biotinylation site [posttranslational modification]; other site 1267754004781 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1267754004782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1267754004783 DNA-binding site [nucleotide binding]; DNA binding site 1267754004784 FCD domain; Region: FCD; pfam07729 1267754004785 hypothetical protein; Provisional; Region: PRK05463 1267754004786 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1267754004787 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1267754004788 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1267754004789 substrate binding site [chemical binding]; other site 1267754004790 THF binding site; other site 1267754004791 zinc-binding site [ion binding]; other site 1267754004792 Secretory lipase; Region: LIP; pfam03583 1267754004793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1267754004794 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1267754004795 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1267754004796 FtsX-like permease family; Region: FtsX; pfam02687 1267754004797 FtsX-like permease family; Region: FtsX; pfam02687 1267754004798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1267754004799 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1267754004800 Walker A/P-loop; other site 1267754004801 ATP binding site [chemical binding]; other site 1267754004802 Q-loop/lid; other site 1267754004803 ABC transporter signature motif; other site 1267754004804 Walker B; other site 1267754004805 D-loop; other site 1267754004806 H-loop/switch region; other site 1267754004807 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1267754004808 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1267754004809 hinge; other site 1267754004810 active site 1267754004811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1267754004812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1267754004813 DNA binding residues [nucleotide binding] 1267754004814 dimerization interface [polypeptide binding]; other site 1267754004815 enoyl-CoA hydratase; Provisional; Region: PRK05862 1267754004816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754004817 substrate binding site [chemical binding]; other site 1267754004818 oxyanion hole (OAH) forming residues; other site 1267754004819 trimer interface [polypeptide binding]; other site 1267754004820 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1267754004821 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1267754004822 dimer interface [polypeptide binding]; other site 1267754004823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754004824 catalytic residue [active] 1267754004825 serine O-acetyltransferase; Region: cysE; TIGR01172 1267754004826 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1267754004827 trimer interface [polypeptide binding]; other site 1267754004828 active site 1267754004829 substrate binding site [chemical binding]; other site 1267754004830 CoA binding site [chemical binding]; other site 1267754004831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1267754004832 Coenzyme A binding pocket [chemical binding]; other site 1267754004833 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1267754004834 putative dimer interface [polypeptide binding]; other site 1267754004835 catalytic triad [active] 1267754004836 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754004837 MULE transposase domain; Region: MULE; pfam10551 1267754004838 putative transposase OrfB; Reviewed; Region: PHA02517 1267754004839 HTH-like domain; Region: HTH_21; pfam13276 1267754004840 Integrase core domain; Region: rve; pfam00665 1267754004841 Integrase core domain; Region: rve_2; pfam13333 1267754004842 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1267754004843 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1267754004844 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1267754004845 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1267754004846 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1267754004847 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1267754004848 FMN binding site [chemical binding]; other site 1267754004849 active site 1267754004850 catalytic residues [active] 1267754004851 substrate binding site [chemical binding]; other site 1267754004852 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1267754004853 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1267754004854 ATP-binding site [chemical binding]; other site 1267754004855 Gluconate-6-phosphate binding site [chemical binding]; other site 1267754004856 PBP superfamily domain; Region: PBP_like_2; cl17296 1267754004857 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1267754004858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1267754004859 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1267754004860 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1267754004861 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1267754004862 heme-binding site [chemical binding]; other site 1267754004863 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 1267754004864 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1267754004865 homodimer interface [polypeptide binding]; other site 1267754004866 substrate-cofactor binding pocket; other site 1267754004867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754004868 catalytic residue [active] 1267754004869 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1267754004870 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1267754004871 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1267754004872 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1267754004873 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1267754004874 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1267754004875 dimerization interface [polypeptide binding]; other site 1267754004876 putative ATP binding site [chemical binding]; other site 1267754004877 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1267754004878 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1267754004879 active site 1267754004880 tetramer interface [polypeptide binding]; other site 1267754004881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754004882 active site 1267754004883 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1267754004884 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1267754004885 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1267754004886 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1267754004887 dimer interface [polypeptide binding]; other site 1267754004888 putative functional site; other site 1267754004889 putative MPT binding site; other site 1267754004890 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1267754004891 fzo-like conserved region; Region: Fzo_mitofusin; pfam04799 1267754004892 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1267754004893 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1267754004894 dimerization interface [polypeptide binding]; other site 1267754004895 ATP binding site [chemical binding]; other site 1267754004896 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1267754004897 dimerization interface [polypeptide binding]; other site 1267754004898 ATP binding site [chemical binding]; other site 1267754004899 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1267754004900 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1267754004901 putative active site [active] 1267754004902 catalytic triad [active] 1267754004903 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1267754004904 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1267754004905 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1267754004906 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1267754004907 active site 1267754004908 catalytic triad [active] 1267754004909 oxyanion hole [active] 1267754004910 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1267754004911 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1267754004912 ATP binding site [chemical binding]; other site 1267754004913 active site 1267754004914 substrate binding site [chemical binding]; other site 1267754004915 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1267754004916 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1267754004917 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1267754004918 adenylosuccinate lyase; Region: purB; TIGR00928 1267754004919 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1267754004920 tetramer interface [polypeptide binding]; other site 1267754004921 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1267754004922 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1267754004923 putative DNA binding site [nucleotide binding]; other site 1267754004924 catalytic residue [active] 1267754004925 putative H2TH interface [polypeptide binding]; other site 1267754004926 putative catalytic residues [active] 1267754004927 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1267754004928 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1267754004929 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1267754004930 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1267754004931 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1267754004932 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1267754004933 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1267754004934 nucleotide binding site/active site [active] 1267754004935 HIT family signature motif; other site 1267754004936 catalytic residue [active] 1267754004937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1267754004938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1267754004939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1267754004940 dimerization interface [polypeptide binding]; other site 1267754004941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1267754004942 dimer interface [polypeptide binding]; other site 1267754004943 phosphorylation site [posttranslational modification] 1267754004944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1267754004945 ATP binding site [chemical binding]; other site 1267754004946 Mg2+ binding site [ion binding]; other site 1267754004947 G-X-G motif; other site 1267754004948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1267754004949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1267754004950 active site 1267754004951 phosphorylation site [posttranslational modification] 1267754004952 intermolecular recognition site; other site 1267754004953 dimerization interface [polypeptide binding]; other site 1267754004954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1267754004955 DNA binding site [nucleotide binding] 1267754004956 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1267754004957 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1267754004958 PhoD-like phosphatase; Region: PhoD; pfam09423 1267754004959 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1267754004960 putative active site [active] 1267754004961 putative metal binding site [ion binding]; other site 1267754004962 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1267754004963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754004964 S-adenosylmethionine binding site [chemical binding]; other site 1267754004965 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1267754004966 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1267754004967 YcaO-like family; Region: YcaO; pfam02624 1267754004968 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1267754004969 NADPH bind site [chemical binding]; other site 1267754004970 putative FMN binding site [chemical binding]; other site 1267754004971 CAAX protease self-immunity; Region: Abi; cl00558 1267754004972 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754004973 MULE transposase domain; Region: MULE; pfam10551 1267754004974 Transposase; Region: HTH_Tnp_1; cl17663 1267754004975 putative transposase OrfB; Reviewed; Region: PHA02517 1267754004976 HTH-like domain; Region: HTH_21; pfam13276 1267754004977 Integrase core domain; Region: rve; pfam00665 1267754004978 Integrase core domain; Region: rve_3; pfam13683 1267754004979 MULE transposase domain; Region: MULE; pfam10551 1267754004980 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1267754004981 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1267754004982 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1267754004983 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1267754004984 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1267754004985 active site 1267754004986 homotetramer interface [polypeptide binding]; other site 1267754004987 META domain; Region: META; cl01245 1267754004988 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1267754004989 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1267754004990 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1267754004991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1267754004992 DNA binding site [nucleotide binding] 1267754004993 domain linker motif; other site 1267754004994 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1267754004995 putative dimerization interface [polypeptide binding]; other site 1267754004996 putative ligand binding site [chemical binding]; other site 1267754004997 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754004998 intersubunit interface [polypeptide binding]; other site 1267754004999 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754005000 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1267754005001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754005002 Walker A/P-loop; other site 1267754005003 ATP binding site [chemical binding]; other site 1267754005004 Q-loop/lid; other site 1267754005005 ABC transporter signature motif; other site 1267754005006 Walker B; other site 1267754005007 D-loop; other site 1267754005008 H-loop/switch region; other site 1267754005009 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1267754005010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1267754005011 dimer interface [polypeptide binding]; other site 1267754005012 putative PBP binding regions; other site 1267754005013 ABC-ATPase subunit interface; other site 1267754005014 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1267754005015 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1267754005016 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1267754005017 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1267754005018 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1267754005019 intersubunit interface [polypeptide binding]; other site 1267754005020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1267754005021 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1267754005022 dimer interface [polypeptide binding]; other site 1267754005023 putative PBP binding regions; other site 1267754005024 ABC-ATPase subunit interface; other site 1267754005025 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1267754005026 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1267754005027 Walker A/P-loop; other site 1267754005028 ATP binding site [chemical binding]; other site 1267754005029 Q-loop/lid; other site 1267754005030 ABC transporter signature motif; other site 1267754005031 Walker B; other site 1267754005032 D-loop; other site 1267754005033 H-loop/switch region; other site 1267754005034 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1267754005035 heme binding pocket [chemical binding]; other site 1267754005036 heme ligand [chemical binding]; other site 1267754005037 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1267754005038 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1267754005039 active site 1267754005040 HIGH motif; other site 1267754005041 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1267754005042 KMSKS motif; other site 1267754005043 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1267754005044 anticodon binding site; other site 1267754005045 tRNA binding surface [nucleotide binding]; other site 1267754005046 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1267754005047 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1267754005048 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1267754005049 homotrimer interaction site [polypeptide binding]; other site 1267754005050 zinc binding site [ion binding]; other site 1267754005051 CDP-binding sites; other site 1267754005052 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1267754005053 substrate binding site; other site 1267754005054 dimer interface; other site 1267754005055 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1267754005056 DNA repair protein RadA; Provisional; Region: PRK11823 1267754005057 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1267754005058 Walker A motif; other site 1267754005059 ATP binding site [chemical binding]; other site 1267754005060 Walker B motif; other site 1267754005061 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1267754005062 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1267754005063 active site clefts [active] 1267754005064 zinc binding site [ion binding]; other site 1267754005065 dimer interface [polypeptide binding]; other site 1267754005066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1267754005067 minor groove reading motif; other site 1267754005068 helix-hairpin-helix signature motif; other site 1267754005069 active site 1267754005070 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1267754005071 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1267754005072 Secretory lipase; Region: LIP; pfam03583 1267754005073 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1267754005074 Clp amino terminal domain; Region: Clp_N; pfam02861 1267754005075 Clp amino terminal domain; Region: Clp_N; pfam02861 1267754005076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754005077 Walker A motif; other site 1267754005078 ATP binding site [chemical binding]; other site 1267754005079 Walker B motif; other site 1267754005080 arginine finger; other site 1267754005081 UvrB/uvrC motif; Region: UVR; pfam02151 1267754005082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754005083 Walker A motif; other site 1267754005084 ATP binding site [chemical binding]; other site 1267754005085 Walker B motif; other site 1267754005086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1267754005087 acyl-CoA synthetase; Provisional; Region: PRK13382 1267754005088 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754005089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754005090 active site 1267754005091 CoA binding site [chemical binding]; other site 1267754005092 AMP binding site [chemical binding]; other site 1267754005093 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1267754005094 NICE-3 protein; Region: NICE-3; pfam07406 1267754005095 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1267754005096 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1267754005097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754005098 active site 1267754005099 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1267754005100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754005101 active site 1267754005102 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1267754005103 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1267754005104 dimer interface [polypeptide binding]; other site 1267754005105 putative anticodon binding site; other site 1267754005106 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1267754005107 motif 1; other site 1267754005108 dimer interface [polypeptide binding]; other site 1267754005109 active site 1267754005110 motif 2; other site 1267754005111 motif 3; other site 1267754005112 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1267754005113 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1267754005114 heme-binding site [chemical binding]; other site 1267754005115 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1267754005116 FAD binding pocket [chemical binding]; other site 1267754005117 FAD binding motif [chemical binding]; other site 1267754005118 phosphate binding motif [ion binding]; other site 1267754005119 beta-alpha-beta structure motif; other site 1267754005120 NAD binding pocket [chemical binding]; other site 1267754005121 Heme binding pocket [chemical binding]; other site 1267754005122 Predicted transcriptional regulator [Transcription]; Region: COG1959 1267754005123 Transcriptional regulator; Region: Rrf2; pfam02082 1267754005124 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1267754005125 tetramerization interface [polypeptide binding]; other site 1267754005126 active site 1267754005127 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1267754005128 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1267754005129 active site 1267754005130 ATP-binding site [chemical binding]; other site 1267754005131 pantoate-binding site; other site 1267754005132 HXXH motif; other site 1267754005133 Rossmann-like domain; Region: Rossmann-like; pfam10727 1267754005134 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1267754005135 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1267754005136 phosphodiesterase; Provisional; Region: PRK12704 1267754005137 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1267754005138 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1267754005139 catalytic center binding site [active] 1267754005140 ATP binding site [chemical binding]; other site 1267754005141 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1267754005142 homooctamer interface [polypeptide binding]; other site 1267754005143 active site 1267754005144 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1267754005145 dihydropteroate synthase; Region: DHPS; TIGR01496 1267754005146 substrate binding pocket [chemical binding]; other site 1267754005147 dimer interface [polypeptide binding]; other site 1267754005148 inhibitor binding site; inhibition site 1267754005149 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1267754005150 homodecamer interface [polypeptide binding]; other site 1267754005151 GTP cyclohydrolase I; Provisional; Region: PLN03044 1267754005152 active site 1267754005153 putative catalytic site residues [active] 1267754005154 zinc binding site [ion binding]; other site 1267754005155 GTP-CH-I/GFRP interaction surface; other site 1267754005156 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1267754005157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754005158 Walker A motif; other site 1267754005159 ATP binding site [chemical binding]; other site 1267754005160 Walker B motif; other site 1267754005161 arginine finger; other site 1267754005162 Peptidase family M41; Region: Peptidase_M41; pfam01434 1267754005163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754005164 active site 1267754005165 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1267754005166 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1267754005167 Ligand Binding Site [chemical binding]; other site 1267754005168 TilS substrate binding domain; Region: TilS; pfam09179 1267754005169 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1267754005170 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1267754005171 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1267754005172 dimer interface [polypeptide binding]; other site 1267754005173 substrate binding site [chemical binding]; other site 1267754005174 metal binding sites [ion binding]; metal-binding site 1267754005175 Abi-like protein; Region: Abi_2; cl01988 1267754005176 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1267754005177 active site residue [active] 1267754005178 Nitronate monooxygenase; Region: NMO; pfam03060 1267754005179 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1267754005180 FMN binding site [chemical binding]; other site 1267754005181 substrate binding site [chemical binding]; other site 1267754005182 putative catalytic residue [active] 1267754005183 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1267754005184 Abi-like protein; Region: Abi_2; pfam07751 1267754005185 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1267754005186 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1267754005187 ring oligomerisation interface [polypeptide binding]; other site 1267754005188 ATP/Mg binding site [chemical binding]; other site 1267754005189 stacking interactions; other site 1267754005190 hinge regions; other site 1267754005191 hypothetical protein; Provisional; Region: PRK07907 1267754005192 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1267754005193 active site 1267754005194 metal binding site [ion binding]; metal-binding site 1267754005195 dimer interface [polypeptide binding]; other site 1267754005196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1267754005197 Carboxylesterase family; Region: COesterase; pfam00135 1267754005198 substrate binding pocket [chemical binding]; other site 1267754005199 catalytic triad [active] 1267754005200 2-isopropylmalate synthase; Validated; Region: PRK03739 1267754005201 carboxylate-amine ligase; Provisional; Region: PRK13517 1267754005202 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1267754005203 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1267754005204 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1267754005205 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1267754005206 active site 1267754005207 catalytic residues [active] 1267754005208 metal binding site [ion binding]; metal-binding site 1267754005209 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1267754005210 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1267754005211 putative catalytic site [active] 1267754005212 putative phosphate binding site [ion binding]; other site 1267754005213 active site 1267754005214 metal binding site A [ion binding]; metal-binding site 1267754005215 DNA binding site [nucleotide binding] 1267754005216 putative AP binding site [nucleotide binding]; other site 1267754005217 putative metal binding site B [ion binding]; other site 1267754005218 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1267754005219 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1267754005220 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1267754005221 putative active site [active] 1267754005222 catalytic site [active] 1267754005223 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1267754005224 putative active site [active] 1267754005225 catalytic site [active] 1267754005226 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1267754005227 MarR family; Region: MarR_2; pfam12802 1267754005228 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1267754005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754005230 putative substrate translocation pore; other site 1267754005231 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1267754005232 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1267754005233 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1267754005234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754005235 Walker A/P-loop; other site 1267754005236 ATP binding site [chemical binding]; other site 1267754005237 Q-loop/lid; other site 1267754005238 ABC transporter signature motif; other site 1267754005239 Walker B; other site 1267754005240 D-loop; other site 1267754005241 H-loop/switch region; other site 1267754005242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1267754005243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1267754005244 substrate binding pocket [chemical binding]; other site 1267754005245 membrane-bound complex binding site; other site 1267754005246 hinge residues; other site 1267754005247 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1267754005248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1267754005249 active site 1267754005250 ATP binding site [chemical binding]; other site 1267754005251 substrate binding site [chemical binding]; other site 1267754005252 activation loop (A-loop); other site 1267754005253 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1267754005254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1267754005255 substrate binding pocket [chemical binding]; other site 1267754005256 membrane-bound complex binding site; other site 1267754005257 hinge residues; other site 1267754005258 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1267754005259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1267754005260 ABC-ATPase subunit interface; other site 1267754005261 putative PBP binding loops; other site 1267754005262 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1267754005263 trimer interface [polypeptide binding]; other site 1267754005264 dimer interface [polypeptide binding]; other site 1267754005265 putative active site [active] 1267754005266 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1267754005267 MPT binding site; other site 1267754005268 trimer interface [polypeptide binding]; other site 1267754005269 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1267754005270 MoaE homodimer interface [polypeptide binding]; other site 1267754005271 MoaD interaction [polypeptide binding]; other site 1267754005272 active site residues [active] 1267754005273 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1267754005274 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1267754005275 putative active site [active] 1267754005276 putative metal binding site [ion binding]; other site 1267754005277 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1267754005278 propionate/acetate kinase; Provisional; Region: PRK12379 1267754005279 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1267754005280 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1267754005281 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1267754005282 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1267754005283 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1267754005284 putative active site [active] 1267754005285 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1267754005286 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1267754005287 CysD dimerization site [polypeptide binding]; other site 1267754005288 G1 box; other site 1267754005289 putative GEF interaction site [polypeptide binding]; other site 1267754005290 GTP/Mg2+ binding site [chemical binding]; other site 1267754005291 Switch I region; other site 1267754005292 G2 box; other site 1267754005293 G3 box; other site 1267754005294 Switch II region; other site 1267754005295 G4 box; other site 1267754005296 G5 box; other site 1267754005297 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1267754005298 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1267754005299 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1267754005300 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1267754005301 Active Sites [active] 1267754005302 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1267754005303 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1267754005304 Active Sites [active] 1267754005305 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1267754005306 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1267754005307 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1267754005308 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1267754005309 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1267754005310 4-coumarate--CoA ligase; Region: PLN02246 1267754005311 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1267754005312 acyl-activating enzyme (AAE) consensus motif; other site 1267754005313 active site 1267754005314 putative CoA binding site [chemical binding]; other site 1267754005315 AMP binding site [chemical binding]; other site 1267754005316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1267754005317 catalytic core [active] 1267754005318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1267754005319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1267754005320 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1267754005321 classical (c) SDRs; Region: SDR_c; cd05233 1267754005322 NAD(P) binding site [chemical binding]; other site 1267754005323 active site 1267754005324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1267754005325 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754005326 active site 1267754005327 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1267754005328 putative active site [active] 1267754005329 putative substrate binding site [chemical binding]; other site 1267754005330 ATP binding site [chemical binding]; other site 1267754005331 D-serine dehydratase; Provisional; Region: PRK02991 1267754005332 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1267754005333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754005334 catalytic residue [active] 1267754005335 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1267754005336 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1267754005337 NAD(P) binding site [chemical binding]; other site 1267754005338 catalytic residues [active] 1267754005339 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1267754005340 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1267754005341 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1267754005342 ferredoxin-NADP+ reductase; Region: PLN02852 1267754005343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1267754005344 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1267754005345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1267754005346 Coenzyme A binding pocket [chemical binding]; other site 1267754005347 hypothetical protein; Validated; Region: PRK01415 1267754005348 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1267754005349 active site residue [active] 1267754005350 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1267754005351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754005352 ATP-grasp domain; Region: ATP-grasp; pfam02222 1267754005353 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1267754005354 iron-sulfur cluster [ion binding]; other site 1267754005355 [2Fe-2S] cluster binding site [ion binding]; other site 1267754005356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754005357 ABC transporter signature motif; other site 1267754005358 Walker B; other site 1267754005359 D-loop; other site 1267754005360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1267754005361 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1267754005362 Walker A/P-loop; other site 1267754005363 ATP binding site [chemical binding]; other site 1267754005364 Q-loop/lid; other site 1267754005365 ABC transporter signature motif; other site 1267754005366 Walker B; other site 1267754005367 D-loop; other site 1267754005368 H-loop/switch region; other site 1267754005369 Cobalt transport protein; Region: CbiQ; cl00463 1267754005370 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1267754005371 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1267754005372 THF binding site; other site 1267754005373 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1267754005374 substrate binding site [chemical binding]; other site 1267754005375 THF binding site; other site 1267754005376 zinc-binding site [ion binding]; other site 1267754005377 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1267754005378 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1267754005379 active site 1267754005380 YibE/F-like protein; Region: YibE_F; pfam07907 1267754005381 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 1267754005382 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1267754005383 alpha-gamma subunit interface [polypeptide binding]; other site 1267754005384 beta-gamma subunit interface [polypeptide binding]; other site 1267754005385 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1267754005386 alpha-beta subunit interface [polypeptide binding]; other site 1267754005387 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1267754005388 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1267754005389 subunit interactions [polypeptide binding]; other site 1267754005390 active site 1267754005391 flap region; other site 1267754005392 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1267754005393 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1267754005394 dimer interface [polypeptide binding]; other site 1267754005395 catalytic residues [active] 1267754005396 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1267754005397 UreF; Region: UreF; pfam01730 1267754005398 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1267754005399 UreD urease accessory protein; Region: UreD; cl00530 1267754005400 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1267754005401 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1267754005402 GDP-binding site [chemical binding]; other site 1267754005403 ACT binding site; other site 1267754005404 IMP binding site; other site 1267754005405 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1267754005406 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1267754005407 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1267754005408 Predicted membrane protein [Function unknown]; Region: COG4129 1267754005409 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1267754005410 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1267754005411 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1267754005412 active site 1267754005413 intersubunit interface [polypeptide binding]; other site 1267754005414 zinc binding site [ion binding]; other site 1267754005415 Na+ binding site [ion binding]; other site 1267754005416 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1267754005417 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1267754005418 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1267754005419 YhhN-like protein; Region: YhhN; pfam07947 1267754005420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1267754005421 active site 1267754005422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1267754005423 EamA-like transporter family; Region: EamA; pfam00892 1267754005424 EamA-like transporter family; Region: EamA; pfam00892 1267754005425 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1267754005426 lipoyl attachment site [posttranslational modification]; other site 1267754005427 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1267754005428 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1267754005429 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1267754005430 glycine dehydrogenase; Provisional; Region: PRK05367 1267754005431 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1267754005432 tetramer interface [polypeptide binding]; other site 1267754005433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754005434 catalytic residue [active] 1267754005435 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1267754005436 tetramer interface [polypeptide binding]; other site 1267754005437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754005438 catalytic residue [active] 1267754005439 short chain dehydrogenase; Provisional; Region: PRK06179 1267754005440 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1267754005441 NADP binding site [chemical binding]; other site 1267754005442 active site 1267754005443 steroid binding site; other site 1267754005444 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1267754005445 HPr interaction site; other site 1267754005446 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1267754005447 active site 1267754005448 phosphorylation site [posttranslational modification] 1267754005449 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1267754005450 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1267754005451 active site residue [active] 1267754005452 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1267754005453 active site residue [active] 1267754005454 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1267754005455 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1267754005456 Clp amino terminal domain; Region: Clp_N; pfam02861 1267754005457 Clp amino terminal domain; Region: Clp_N; pfam02861 1267754005458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754005459 Walker A motif; other site 1267754005460 ATP binding site [chemical binding]; other site 1267754005461 Walker B motif; other site 1267754005462 arginine finger; other site 1267754005463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754005464 Walker A motif; other site 1267754005465 ATP binding site [chemical binding]; other site 1267754005466 Walker B motif; other site 1267754005467 arginine finger; other site 1267754005468 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1267754005469 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1267754005470 FAD binding pocket [chemical binding]; other site 1267754005471 FAD binding motif [chemical binding]; other site 1267754005472 phosphate binding motif [ion binding]; other site 1267754005473 beta-alpha-beta structure motif; other site 1267754005474 NAD binding pocket [chemical binding]; other site 1267754005475 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1267754005476 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1267754005477 putative active site [active] 1267754005478 catalytic triad [active] 1267754005479 putative dimer interface [polypeptide binding]; other site 1267754005480 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1267754005481 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1267754005482 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1267754005483 DNA binding residues [nucleotide binding] 1267754005484 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1267754005485 putative dimer interface [polypeptide binding]; other site 1267754005486 chaperone protein DnaJ; Provisional; Region: PRK14279 1267754005487 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1267754005488 HSP70 interaction site [polypeptide binding]; other site 1267754005489 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1267754005490 Zn binding sites [ion binding]; other site 1267754005491 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1267754005492 dimer interface [polypeptide binding]; other site 1267754005493 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1267754005494 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1267754005495 NAD(P) binding site [chemical binding]; other site 1267754005496 catalytic residues [active] 1267754005497 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1267754005498 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1267754005499 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1267754005500 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1267754005501 nucleotide binding site [chemical binding]; other site 1267754005502 NEF interaction site [polypeptide binding]; other site 1267754005503 SBD interface [polypeptide binding]; other site 1267754005504 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1267754005505 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1267754005506 4Fe-4S binding domain; Region: Fer4; cl02805 1267754005507 4Fe-4S binding domain; Region: Fer4; pfam00037 1267754005508 Cysteine-rich domain; Region: CCG; pfam02754 1267754005509 Cysteine-rich domain; Region: CCG; pfam02754 1267754005510 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1267754005511 active site 1267754005512 DNA binding site [nucleotide binding] 1267754005513 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1267754005514 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754005515 putative transposase OrfB; Reviewed; Region: PHA02517 1267754005516 HTH-like domain; Region: HTH_21; pfam13276 1267754005517 Integrase core domain; Region: rve; pfam00665 1267754005518 Integrase core domain; Region: rve_3; pfam13683 1267754005519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1267754005520 Transposase; Region: HTH_Tnp_1; pfam01527 1267754005521 putative transposase OrfB; Reviewed; Region: PHA02517 1267754005522 Integrase core domain; Region: rve; pfam00665 1267754005523 Integrase core domain; Region: rve_3; cl15866 1267754005524 Transposase; Region: HTH_Tnp_1; cl17663 1267754005525 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1267754005526 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1267754005527 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1267754005528 NAD binding site [chemical binding]; other site 1267754005529 substrate binding site [chemical binding]; other site 1267754005530 catalytic Zn binding site [ion binding]; other site 1267754005531 tetramer interface [polypeptide binding]; other site 1267754005532 structural Zn binding site [ion binding]; other site 1267754005533 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1267754005534 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1267754005535 Integrase core domain; Region: rve; pfam00665 1267754005536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754005537 aminotransferase AlaT; Validated; Region: PRK09265 1267754005538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1267754005539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754005540 homodimer interface [polypeptide binding]; other site 1267754005541 catalytic residue [active] 1267754005542 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1267754005543 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1267754005544 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1267754005545 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1267754005546 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1267754005547 trimer interface [polypeptide binding]; other site 1267754005548 active site 1267754005549 LssY C-terminus; Region: LssY_C; pfam14067 1267754005550 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1267754005551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1267754005552 non-specific DNA binding site [nucleotide binding]; other site 1267754005553 salt bridge; other site 1267754005554 sequence-specific DNA binding site [nucleotide binding]; other site 1267754005555 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1267754005556 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1267754005557 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1267754005558 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1267754005559 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1267754005560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1267754005561 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1267754005562 Putative esterase; Region: Esterase; pfam00756 1267754005563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754005564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1267754005565 putative substrate translocation pore; other site 1267754005566 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1267754005567 acyl-coenzyme A oxidase; Region: PLN02636 1267754005568 active site 1267754005569 Predicted membrane protein [Function unknown]; Region: COG1289 1267754005570 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1267754005571 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1267754005572 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1267754005573 gating phenylalanine in ion channel; other site 1267754005574 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1267754005575 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1267754005576 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1267754005577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1267754005578 dimerization interface [polypeptide binding]; other site 1267754005579 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1267754005580 cyclase homology domain; Region: CHD; cd07302 1267754005581 nucleotidyl binding site; other site 1267754005582 metal binding site [ion binding]; metal-binding site 1267754005583 dimer interface [polypeptide binding]; other site 1267754005584 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1267754005585 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1267754005586 active site 1267754005587 interdomain interaction site; other site 1267754005588 putative metal-binding site [ion binding]; other site 1267754005589 nucleotide binding site [chemical binding]; other site 1267754005590 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1267754005591 domain I; other site 1267754005592 phosphate binding site [ion binding]; other site 1267754005593 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1267754005594 domain II; other site 1267754005595 domain III; other site 1267754005596 nucleotide binding site [chemical binding]; other site 1267754005597 DNA binding groove [nucleotide binding] 1267754005598 catalytic site [active] 1267754005599 domain IV; other site 1267754005600 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1267754005601 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1267754005602 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1267754005603 DNA-binding site [nucleotide binding]; DNA binding site 1267754005604 RNA-binding motif; other site 1267754005605 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1267754005606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1267754005607 ATP binding site [chemical binding]; other site 1267754005608 putative Mg++ binding site [ion binding]; other site 1267754005609 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1267754005610 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1267754005611 Secretory lipase; Region: LIP; pfam03583 1267754005612 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1267754005613 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1267754005614 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1267754005615 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1267754005616 Walker A motif; other site 1267754005617 ATP binding site [chemical binding]; other site 1267754005618 Walker B motif; other site 1267754005619 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1267754005620 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1267754005621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1267754005622 motif II; other site 1267754005623 Fic family protein [Function unknown]; Region: COG3177 1267754005624 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1267754005625 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1267754005626 PGAP1-like protein; Region: PGAP1; pfam07819 1267754005627 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1267754005628 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1267754005629 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1267754005630 putative active site [active] 1267754005631 putative CoA binding site [chemical binding]; other site 1267754005632 nudix motif; other site 1267754005633 metal binding site [ion binding]; metal-binding site 1267754005634 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1267754005635 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1267754005636 catalytic residues [active] 1267754005637 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1267754005638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1267754005639 minor groove reading motif; other site 1267754005640 helix-hairpin-helix signature motif; other site 1267754005641 substrate binding pocket [chemical binding]; other site 1267754005642 active site 1267754005643 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1267754005644 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1267754005645 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1267754005646 ligand binding site [chemical binding]; other site 1267754005647 flexible hinge region; other site 1267754005648 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1267754005649 putative switch regulator; other site 1267754005650 non-specific DNA interactions [nucleotide binding]; other site 1267754005651 DNA binding site [nucleotide binding] 1267754005652 sequence specific DNA binding site [nucleotide binding]; other site 1267754005653 putative cAMP binding site [chemical binding]; other site 1267754005654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1267754005655 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1267754005656 homotrimer interaction site [polypeptide binding]; other site 1267754005657 putative active site [active] 1267754005658 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1267754005659 Transcription factor WhiB; Region: Whib; pfam02467 1267754005660 Transglycosylase; Region: Transgly; pfam00912 1267754005661 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1267754005662 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1267754005663 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1267754005664 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1267754005665 active site 1267754005666 metal binding site [ion binding]; metal-binding site 1267754005667 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1267754005668 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1267754005669 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1267754005670 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1267754005671 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1267754005672 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1267754005673 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1267754005674 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1267754005675 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1267754005676 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1267754005677 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1267754005678 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1267754005679 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1267754005680 heme binding pocket [chemical binding]; other site 1267754005681 RNA polymerase sigma factor; Provisional; Region: PRK12535 1267754005682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1267754005683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1267754005684 DNA binding residues [nucleotide binding] 1267754005685 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1267754005686 hydrophobic ligand binding site; other site 1267754005687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1267754005688 TIGR01777 family protein; Region: yfcH 1267754005689 NAD(P) binding site [chemical binding]; other site 1267754005690 active site 1267754005691 ferrochelatase; Reviewed; Region: hemH; PRK00035 1267754005692 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1267754005693 C-terminal domain interface [polypeptide binding]; other site 1267754005694 active site 1267754005695 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1267754005696 active site 1267754005697 N-terminal domain interface [polypeptide binding]; other site 1267754005698 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1267754005699 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1267754005700 aspartate kinase; Reviewed; Region: PRK06635 1267754005701 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1267754005702 putative nucleotide binding site [chemical binding]; other site 1267754005703 putative catalytic residues [active] 1267754005704 putative Mg ion binding site [ion binding]; other site 1267754005705 putative aspartate binding site [chemical binding]; other site 1267754005706 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1267754005707 putative allosteric regulatory site; other site 1267754005708 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1267754005709 putative allosteric regulatory residue; other site 1267754005710 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1267754005711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754005712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1267754005713 acyl-activating enzyme (AAE) consensus motif; other site 1267754005714 AMP binding site [chemical binding]; other site 1267754005715 active site 1267754005716 CoA binding site [chemical binding]; other site 1267754005717 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1267754005718 metal ion-dependent adhesion site (MIDAS); other site 1267754005719 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1267754005720 active site 1267754005721 catalytic site [active] 1267754005722 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1267754005723 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1267754005724 active site 1267754005725 catalytic site [active] 1267754005726 2-isopropylmalate synthase; Validated; Region: PRK03739 1267754005727 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1267754005728 active site 1267754005729 catalytic residues [active] 1267754005730 metal binding site [ion binding]; metal-binding site 1267754005731 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1267754005732 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1267754005733 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1267754005734 active site 1267754005735 substrate binding site [chemical binding]; other site 1267754005736 catalytic site [active] 1267754005737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1267754005738 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1267754005739 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1267754005740 conserved cys residue [active] 1267754005741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1267754005742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1267754005743 recombination protein RecR; Reviewed; Region: recR; PRK00076 1267754005744 RecR protein; Region: RecR; pfam02132 1267754005745 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1267754005746 active site 1267754005747 metal binding site [ion binding]; metal-binding site 1267754005748 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1267754005749 active site 1267754005750 metal binding site [ion binding]; metal-binding site 1267754005751 hypothetical protein; Validated; Region: PRK00153 1267754005752 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1267754005753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1267754005754 Walker A motif; other site 1267754005755 ATP binding site [chemical binding]; other site 1267754005756 Walker B motif; other site 1267754005757 arginine finger; other site 1267754005758 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1267754005759 TM2 domain; Region: TM2; pfam05154 1267754005760 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1267754005761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1267754005762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754005763 catalytic residue [active] 1267754005764 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1267754005765 MULE transposase domain; Region: MULE; pfam10551 1267754005766 MULE transposase domain; Region: MULE; pfam10551 1267754005767 MULE transposase domain; Region: MULE; pfam10551 1267754005768 MULE transposase domain; Region: MULE; pfam10551 1267754005769 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1267754005770 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 1267754005771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1267754005772 MULE transposase domain; Region: MULE; pfam10551 1267754005773 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1267754005774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1267754005775 substrate binding site [chemical binding]; other site 1267754005776 oxyanion hole (OAH) forming residues; other site 1267754005777 trimer interface [polypeptide binding]; other site 1267754005778 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1267754005779 active site 1267754005780 HIGH motif; other site 1267754005781 nucleotide binding site [chemical binding]; other site 1267754005782 active site 1267754005783 KMSKS motif; other site 1267754005784 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1267754005785 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1267754005786 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1267754005787 CAAX protease self-immunity; Region: Abi; pfam02517 1267754005788 Abi-like protein; Region: Abi_2; pfam07751 1267754005789 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1267754005790 nucleoside/Zn binding site; other site 1267754005791 dimer interface [polypeptide binding]; other site 1267754005792 catalytic motif [active] 1267754005793 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1267754005794 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1267754005795 prephenate dehydrogenase; Validated; Region: PRK08507 1267754005796 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1267754005797 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1267754005798 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1267754005799 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1267754005800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1267754005801 homodimer interface [polypeptide binding]; other site 1267754005802 catalytic residue [active] 1267754005803 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1267754005804 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1267754005805 transmembrane helices; other site 1267754005806 Predicted membrane protein [Function unknown]; Region: COG1511 1267754005807 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1267754005808 Predicted membrane protein [Function unknown]; Region: COG1511 1267754005809 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1267754005810 Predicted membrane protein [Function unknown]; Region: COG1511 1267754005811 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1267754005812 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1267754005813 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1267754005814 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1267754005815 NAD(P) binding site [chemical binding]; other site 1267754005816 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1267754005817 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1267754005818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1267754005819 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1267754005820 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1267754005821 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1267754005822 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1267754005823 Walker A/P-loop; other site 1267754005824 ATP binding site [chemical binding]; other site 1267754005825 Q-loop/lid; other site 1267754005826 ABC transporter signature motif; other site 1267754005827 Walker B; other site 1267754005828 D-loop; other site 1267754005829 H-loop/switch region; other site 1267754005830 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1267754005831 active site 1267754005832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1267754005833 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1267754005834 Predicted membrane protein [Function unknown]; Region: COG2246 1267754005835 GtrA-like protein; Region: GtrA; pfam04138 1267754005836 Predicted membrane protein [Function unknown]; Region: COG2246 1267754005837 GtrA-like protein; Region: GtrA; pfam04138 1267754005838 FAD binding domain; Region: FAD_binding_4; pfam01565 1267754005839 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1267754005840 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1267754005841 short chain dehydrogenase; Provisional; Region: PRK08251 1267754005842 classical (c) SDRs; Region: SDR_c; cd05233 1267754005843 NAD(P) binding site [chemical binding]; other site 1267754005844 active site 1267754005845 Cutinase; Region: Cutinase; pfam01083 1267754005846 Helix-turn-helix domain; Region: HTH_38; pfam13936 1267754005847 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1267754005848 Integrase core domain; Region: rve; pfam00665 1267754005849 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1267754005850 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1267754005851 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1267754005852 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1267754005853 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1267754005854 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1267754005855 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1267754005856 helicase Cas3; Provisional; Region: PRK09694 1267754005857 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1267754005858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1267754005859 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1267754005860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754005861 putative substrate translocation pore; other site 1267754005862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754005863 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1267754005864 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1267754005865 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1267754005866 catalytic residues [active] 1267754005867 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1267754005868 CoenzymeA binding site [chemical binding]; other site 1267754005869 subunit interaction site [polypeptide binding]; other site 1267754005870 PHB binding site; other site 1267754005871 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1267754005872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754005873 Walker A/P-loop; other site 1267754005874 ATP binding site [chemical binding]; other site 1267754005875 Q-loop/lid; other site 1267754005876 ABC transporter signature motif; other site 1267754005877 Walker B; other site 1267754005878 D-loop; other site 1267754005879 H-loop/switch region; other site 1267754005880 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1267754005881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1267754005882 MarR family; Region: MarR_2; pfam12802 1267754005883 replicative DNA helicase; Provisional; Region: PRK05636 1267754005884 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1267754005885 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1267754005886 Walker A motif; other site 1267754005887 ATP binding site [chemical binding]; other site 1267754005888 Walker B motif; other site 1267754005889 DNA binding loops [nucleotide binding] 1267754005890 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1267754005891 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1267754005892 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1267754005893 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1267754005894 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1267754005895 dimer interface [polypeptide binding]; other site 1267754005896 ssDNA binding site [nucleotide binding]; other site 1267754005897 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1267754005898 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1267754005899 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1267754005900 Predicted integral membrane protein [Function unknown]; Region: COG5650 1267754005901 Transglycosylase; Region: Transgly; pfam00912 1267754005902 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1267754005903 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1267754005904 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1267754005905 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1267754005906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1267754005907 MarR family; Region: MarR; pfam01047 1267754005908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1267754005909 Ligand Binding Site [chemical binding]; other site 1267754005910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1267754005911 Ligand Binding Site [chemical binding]; other site 1267754005912 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1267754005913 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1267754005914 HIGH motif; other site 1267754005915 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1267754005916 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1267754005917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1267754005918 active site 1267754005919 KMSKS motif; other site 1267754005920 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1267754005921 tRNA binding surface [nucleotide binding]; other site 1267754005922 anticodon binding site; other site 1267754005923 SdpI/YhfL protein family; Region: SdpI; pfam13630 1267754005924 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1267754005925 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1267754005926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1267754005927 Walker A/P-loop; other site 1267754005928 ATP binding site [chemical binding]; other site 1267754005929 Q-loop/lid; other site 1267754005930 ABC transporter signature motif; other site 1267754005931 Walker B; other site 1267754005932 D-loop; other site 1267754005933 H-loop/switch region; other site 1267754005934 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1267754005935 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1267754005936 substrate binding site [chemical binding]; other site 1267754005937 dimer interface [polypeptide binding]; other site 1267754005938 ATP binding site [chemical binding]; other site 1267754005939 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1267754005940 active site 1267754005941 tetramer interface [polypeptide binding]; other site 1267754005942 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1267754005943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1267754005944 putative substrate translocation pore; other site 1267754005945 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1267754005946 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1267754005947 NAD(P) binding site [chemical binding]; other site 1267754005948 catalytic residues [active] 1267754005949 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1267754005950 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1267754005951 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1267754005952 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1267754005953 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1267754005954 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1267754005955 nudix motif; other site 1267754005956 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1267754005957 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1267754005958 active site 1267754005959 NTP binding site [chemical binding]; other site 1267754005960 metal binding triad [ion binding]; metal-binding site 1267754005961 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1267754005962 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1267754005963 Zn2+ binding site [ion binding]; other site 1267754005964 Mg2+ binding site [ion binding]; other site 1267754005965 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1267754005966 active site 1267754005967 Ap6A binding site [chemical binding]; other site 1267754005968 nudix motif; other site 1267754005969 metal binding site [ion binding]; metal-binding site 1267754005970 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1267754005971 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1267754005972 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1267754005973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1267754005974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1267754005975 DNA binding residues [nucleotide binding] 1267754005976 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1267754005977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1267754005978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1267754005979 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1267754005980 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1267754005981 catalytic residues [active] 1267754005982 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1267754005983 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1267754005984 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1267754005985 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1267754005986 active site 1267754005987 metal binding site [ion binding]; metal-binding site 1267754005988 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1267754005989 ParB-like nuclease domain; Region: ParB; smart00470 1267754005990 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1267754005991 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1267754005992 P-loop; other site 1267754005993 Magnesium ion binding site [ion binding]; other site 1267754005994 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1267754005995 Magnesium ion binding site [ion binding]; other site 1267754005996 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1267754005997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1267754005998 S-adenosylmethionine binding site [chemical binding]; other site 1267754005999 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1267754006000 Haemolytic domain; Region: Haemolytic; pfam01809 1267754006001 Ribonuclease P; Region: Ribonuclease_P; cl00457 1267754006002 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399