-- dump date 20140619_053153 -- class Genbank::misc_feature -- table misc_feature_note -- id note 858619000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 858619000003 Walker A motif; other site 858619000004 ATP binding site [chemical binding]; other site 858619000005 Walker B motif; other site 858619000006 arginine finger; other site 858619000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 858619000008 DnaA box-binding interface [nucleotide binding]; other site 858619000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 858619000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 858619000011 putative DNA binding surface [nucleotide binding]; other site 858619000012 dimer interface [polypeptide binding]; other site 858619000013 beta-clamp/clamp loader binding surface; other site 858619000014 beta-clamp/translesion DNA polymerase binding surface; other site 858619000015 recombination protein F; Reviewed; Region: recF; PRK00064 858619000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 858619000017 Walker A/P-loop; other site 858619000018 ATP binding site [chemical binding]; other site 858619000019 Q-loop/lid; other site 858619000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000021 ABC transporter signature motif; other site 858619000022 Walker B; other site 858619000023 D-loop; other site 858619000024 H-loop/switch region; other site 858619000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 858619000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 858619000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619000028 ATP binding site [chemical binding]; other site 858619000029 Mg2+ binding site [ion binding]; other site 858619000030 G-X-G motif; other site 858619000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 858619000032 anchoring element; other site 858619000033 dimer interface [polypeptide binding]; other site 858619000034 ATP binding site [chemical binding]; other site 858619000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 858619000036 active site 858619000037 putative metal-binding site [ion binding]; other site 858619000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 858619000039 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 858619000040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 858619000041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619000042 putative DNA binding site [nucleotide binding]; other site 858619000043 putative Zn2+ binding site [ion binding]; other site 858619000044 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 858619000045 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 858619000046 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 858619000047 active site 858619000048 dimer interface [polypeptide binding]; other site 858619000049 non-prolyl cis peptide bond; other site 858619000050 insertion regions; other site 858619000051 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 858619000052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619000053 dimer interface [polypeptide binding]; other site 858619000054 conserved gate region; other site 858619000055 putative PBP binding loops; other site 858619000056 ABC-ATPase subunit interface; other site 858619000057 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 858619000058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 858619000059 substrate binding pocket [chemical binding]; other site 858619000060 membrane-bound complex binding site; other site 858619000061 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 858619000062 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 858619000063 Walker A/P-loop; other site 858619000064 ATP binding site [chemical binding]; other site 858619000065 Q-loop/lid; other site 858619000066 ABC transporter signature motif; other site 858619000067 Walker B; other site 858619000068 D-loop; other site 858619000069 H-loop/switch region; other site 858619000070 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619000071 active site 858619000072 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 858619000073 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619000074 FAD binding pocket [chemical binding]; other site 858619000075 FAD binding motif [chemical binding]; other site 858619000076 phosphate binding motif [ion binding]; other site 858619000077 NAD binding pocket [chemical binding]; other site 858619000078 DNA gyrase subunit A; Validated; Region: PRK05560 858619000079 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 858619000080 CAP-like domain; other site 858619000081 active site 858619000082 primary dimer interface [polypeptide binding]; other site 858619000083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 858619000084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 858619000085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 858619000086 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 858619000087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 858619000088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 858619000089 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 858619000090 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 858619000091 active site 858619000092 catalytic triad [active] 858619000093 oxyanion hole [active] 858619000094 acyl-CoA synthetase; Validated; Region: PRK07788 858619000095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619000096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619000097 acyl-activating enzyme (AAE) consensus motif; other site 858619000098 AMP binding site [chemical binding]; other site 858619000099 active site 858619000100 CoA binding site [chemical binding]; other site 858619000101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619000102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619000103 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 858619000104 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 858619000105 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 858619000106 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 858619000107 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 858619000108 active site 858619000109 iron coordination sites [ion binding]; other site 858619000110 substrate binding pocket [chemical binding]; other site 858619000111 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 858619000112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619000113 Domain of unknown function (DU1801); Region: DUF1801; cl17490 858619000114 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 858619000115 ABC1 family; Region: ABC1; cl17513 858619000116 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 858619000117 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 858619000118 active site 858619000119 non-prolyl cis peptide bond; other site 858619000120 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619000121 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 858619000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 858619000123 S-adenosylmethionine binding site [chemical binding]; other site 858619000124 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 858619000125 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 858619000126 active site 858619000127 catalytic site [active] 858619000128 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 858619000129 Lipase (class 2); Region: Lipase_2; pfam01674 858619000130 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619000131 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619000132 intersubunit interface [polypeptide binding]; other site 858619000133 short chain dehydrogenase; Provisional; Region: PRK08267 858619000134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619000135 NAD(P) binding site [chemical binding]; other site 858619000136 active site 858619000137 BCCT family transporter; Region: BCCT; pfam02028 858619000138 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 858619000139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619000140 NAD(P) binding site [chemical binding]; other site 858619000141 active site 858619000142 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 858619000143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619000144 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 858619000145 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619000146 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 858619000147 proline/glycine betaine transporter; Provisional; Region: PRK10642 858619000148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000149 putative substrate translocation pore; other site 858619000150 Predicted membrane protein [Function unknown]; Region: COG2323 858619000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619000153 putative substrate translocation pore; other site 858619000154 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 858619000155 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 858619000156 DNA binding residues [nucleotide binding] 858619000157 dimer interface [polypeptide binding]; other site 858619000158 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 858619000159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619000160 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 858619000161 active site 858619000162 motif I; other site 858619000163 motif II; other site 858619000164 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 858619000165 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619000166 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619000167 FAD binding pocket [chemical binding]; other site 858619000168 FAD binding motif [chemical binding]; other site 858619000169 phosphate binding motif [ion binding]; other site 858619000170 NAD binding pocket [chemical binding]; other site 858619000171 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619000172 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619000173 intersubunit interface [polypeptide binding]; other site 858619000174 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619000175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619000176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619000177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619000178 putative DNA binding site [nucleotide binding]; other site 858619000179 putative Zn2+ binding site [ion binding]; other site 858619000180 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 858619000181 putative dimerization interface [polypeptide binding]; other site 858619000182 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 858619000183 EamA-like transporter family; Region: EamA; pfam00892 858619000184 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 858619000185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 858619000186 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 858619000187 active site 858619000188 Rhomboid family; Region: Rhomboid; cl11446 858619000189 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 858619000190 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 858619000191 Glutamine amidotransferase class-I; Region: GATase; pfam00117 858619000192 glutamine binding [chemical binding]; other site 858619000193 catalytic triad [active] 858619000194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619000195 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 858619000196 Coenzyme A binding pocket [chemical binding]; other site 858619000197 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 858619000198 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 858619000199 active site 858619000200 ATP binding site [chemical binding]; other site 858619000201 substrate binding site [chemical binding]; other site 858619000202 activation loop (A-loop); other site 858619000203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 858619000204 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619000205 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619000206 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619000207 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619000208 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 858619000209 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 858619000210 active site 858619000211 ATP binding site [chemical binding]; other site 858619000212 substrate binding site [chemical binding]; other site 858619000213 activation loop (A-loop); other site 858619000214 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 858619000215 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 858619000216 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 858619000217 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 858619000218 active site 858619000219 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 858619000220 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 858619000221 phosphopeptide binding site; other site 858619000222 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 858619000223 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 858619000224 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 858619000225 phosphopeptide binding site; other site 858619000226 Transposase; Region: HTH_Tnp_1; cl17663 858619000227 putative transposase OrfB; Reviewed; Region: PHA02517 858619000228 Integrase core domain; Region: rve; pfam00665 858619000229 Integrase core domain; Region: rve_2; pfam13333 858619000230 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619000231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619000232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619000233 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619000234 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 858619000235 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619000236 DNA-binding interface [nucleotide binding]; DNA binding site 858619000237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 858619000238 Integrase core domain; Region: rve; pfam00665 858619000239 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 858619000240 catalytic residue [active] 858619000241 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 858619000242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619000243 Transposase; Region: HTH_Tnp_1; pfam01527 858619000244 Integrase core domain; Region: rve; pfam00665 858619000245 Integrase core domain; Region: rve_3; cl15866 858619000246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619000247 Transposase; Region: HTH_Tnp_1; cl17663 858619000248 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 858619000249 LGFP repeat; Region: LGFP; pfam08310 858619000250 LGFP repeat; Region: LGFP; pfam08310 858619000251 LGFP repeat; Region: LGFP; pfam08310 858619000252 putative transposase OrfB; Reviewed; Region: PHA02517 858619000253 HTH-like domain; Region: HTH_21; pfam13276 858619000254 Integrase core domain; Region: rve; pfam00665 858619000255 Integrase core domain; Region: rve_3; pfam13683 858619000256 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 858619000257 MMPL family; Region: MMPL; pfam03176 858619000258 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 858619000259 Fasciclin domain; Region: Fasciclin; pfam02469 858619000260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000261 putative substrate translocation pore; other site 858619000262 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 858619000263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 858619000264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619000265 Coenzyme A binding pocket [chemical binding]; other site 858619000266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 858619000267 DNA-binding site [nucleotide binding]; DNA binding site 858619000268 RNA-binding motif; other site 858619000269 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 858619000270 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 858619000271 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 858619000272 Walker A/P-loop; other site 858619000273 ATP binding site [chemical binding]; other site 858619000274 Q-loop/lid; other site 858619000275 ABC transporter signature motif; other site 858619000276 Walker B; other site 858619000277 D-loop; other site 858619000278 H-loop/switch region; other site 858619000279 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 858619000280 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 858619000281 FtsX-like permease family; Region: FtsX; pfam02687 858619000282 FtsX-like permease family; Region: FtsX; pfam02687 858619000283 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 858619000284 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 858619000285 dimer interface [polypeptide binding]; other site 858619000286 active site 858619000287 metal binding site [ion binding]; metal-binding site 858619000288 Predicted membrane protein [Function unknown]; Region: COG1297 858619000289 putative oligopeptide transporter, OPT family; Region: TIGR00733 858619000290 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 858619000291 Predicted flavoprotein [General function prediction only]; Region: COG0431 858619000292 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 858619000293 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 858619000294 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 858619000295 active site 858619000296 catalytic triad [active] 858619000297 oxyanion hole [active] 858619000298 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 858619000299 active site 858619000300 catalytic motif [active] 858619000301 Zn binding site [ion binding]; other site 858619000302 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 858619000303 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 858619000304 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 858619000305 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 858619000306 Putative esterase; Region: Esterase; pfam00756 858619000307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619000308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619000309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000310 Walker A/P-loop; other site 858619000311 ATP binding site [chemical binding]; other site 858619000312 Q-loop/lid; other site 858619000313 ABC transporter signature motif; other site 858619000314 Walker B; other site 858619000315 D-loop; other site 858619000316 H-loop/switch region; other site 858619000317 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619000318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619000319 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 858619000320 Walker A/P-loop; other site 858619000321 ATP binding site [chemical binding]; other site 858619000322 Q-loop/lid; other site 858619000323 ABC transporter signature motif; other site 858619000324 Walker B; other site 858619000325 D-loop; other site 858619000326 H-loop/switch region; other site 858619000327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 858619000328 hydrophobic ligand binding site; other site 858619000329 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 858619000330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000331 Walker A/P-loop; other site 858619000332 ATP binding site [chemical binding]; other site 858619000333 Q-loop/lid; other site 858619000334 ABC transporter signature motif; other site 858619000335 Walker B; other site 858619000336 D-loop; other site 858619000337 H-loop/switch region; other site 858619000338 ABC transporter; Region: ABC_tran_2; pfam12848 858619000339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619000340 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 858619000341 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 858619000342 acyl-activating enzyme (AAE) consensus motif; other site 858619000343 AMP binding site [chemical binding]; other site 858619000344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 858619000345 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 858619000346 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 858619000347 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 858619000348 putative trimer interface [polypeptide binding]; other site 858619000349 putative CoA binding site [chemical binding]; other site 858619000350 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 858619000351 Zn binding site [ion binding]; other site 858619000352 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 858619000353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619000354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619000355 Methyltransferase domain; Region: Methyltransf_31; pfam13847 858619000356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619000357 S-adenosylmethionine binding site [chemical binding]; other site 858619000358 Predicted membrane protein [Function unknown]; Region: COG2259 858619000359 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 858619000360 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 858619000361 NAD(P) binding site [chemical binding]; other site 858619000362 catalytic residues [active] 858619000363 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 858619000364 intracellular protease, PfpI family; Region: PfpI; TIGR01382 858619000365 proposed catalytic triad [active] 858619000366 conserved cys residue [active] 858619000367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 858619000368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 858619000369 active site 858619000370 catalytic tetrad [active] 858619000371 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 858619000372 Domain of unknown function DUF21; Region: DUF21; pfam01595 858619000373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 858619000374 Transporter associated domain; Region: CorC_HlyC; pfam03471 858619000375 Domain of unknown function DUF21; Region: DUF21; pfam01595 858619000376 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 858619000377 Transcriptional regulators [Transcription]; Region: MarR; COG1846 858619000378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619000379 putative DNA binding site [nucleotide binding]; other site 858619000380 putative Zn2+ binding site [ion binding]; other site 858619000381 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 858619000382 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 858619000383 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 858619000384 putative NAD(P) binding site [chemical binding]; other site 858619000385 putative dimer interface [polypeptide binding]; other site 858619000386 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 858619000387 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 858619000388 active site 2 [active] 858619000389 active site 1 [active] 858619000390 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 858619000391 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 858619000392 dimerization interface [polypeptide binding]; other site 858619000393 DPS ferroxidase diiron center [ion binding]; other site 858619000394 ion pore; other site 858619000395 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 858619000396 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 858619000397 Excalibur calcium-binding domain; Region: Excalibur; smart00894 858619000398 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 858619000399 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 858619000400 Fic family protein [Function unknown]; Region: COG3177 858619000401 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 858619000402 Fic/DOC family; Region: Fic; pfam02661 858619000403 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 858619000404 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 858619000405 substrate binding pocket [chemical binding]; other site 858619000406 catalytic triad [active] 858619000407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 858619000408 Rubredoxin [Energy production and conversion]; Region: COG1773 858619000409 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 858619000410 iron binding site [ion binding]; other site 858619000411 Rubredoxin [Energy production and conversion]; Region: COG1773 858619000412 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 858619000413 iron binding site [ion binding]; other site 858619000414 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 858619000415 Fatty acid desaturase; Region: FA_desaturase; pfam00487 858619000416 Di-iron ligands [ion binding]; other site 858619000417 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 858619000418 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 858619000419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000420 Walker A/P-loop; other site 858619000421 ATP binding site [chemical binding]; other site 858619000422 Q-loop/lid; other site 858619000423 ABC transporter signature motif; other site 858619000424 Walker B; other site 858619000425 D-loop; other site 858619000426 H-loop/switch region; other site 858619000427 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 858619000428 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 858619000429 Catalytic site [active] 858619000430 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 858619000431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619000433 active site 858619000434 phosphorylation site [posttranslational modification] 858619000435 intermolecular recognition site; other site 858619000436 dimerization interface [polypeptide binding]; other site 858619000437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619000438 DNA binding residues [nucleotide binding] 858619000439 dimerization interface [polypeptide binding]; other site 858619000440 Histidine kinase; Region: HisKA_3; pfam07730 858619000441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619000442 ATP binding site [chemical binding]; other site 858619000443 Mg2+ binding site [ion binding]; other site 858619000444 G-X-G motif; other site 858619000445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 858619000446 FtsX-like permease family; Region: FtsX; pfam02687 858619000447 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 858619000448 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 858619000449 Walker A/P-loop; other site 858619000450 ATP binding site [chemical binding]; other site 858619000451 Q-loop/lid; other site 858619000452 ABC transporter signature motif; other site 858619000453 Walker B; other site 858619000454 D-loop; other site 858619000455 H-loop/switch region; other site 858619000456 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 858619000457 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 858619000458 alkaline phosphatase; Provisional; Region: PRK10518 858619000459 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 858619000460 active site 858619000461 dimer interface [polypeptide binding]; other site 858619000462 maltose O-acetyltransferase; Provisional; Region: PRK10092 858619000463 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 858619000464 active site 858619000465 substrate binding site [chemical binding]; other site 858619000466 trimer interface [polypeptide binding]; other site 858619000467 CoA binding site [chemical binding]; other site 858619000468 cystathionine gamma-synthase; Provisional; Region: PRK07811 858619000469 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 858619000470 homodimer interface [polypeptide binding]; other site 858619000471 substrate-cofactor binding pocket; other site 858619000472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619000473 catalytic residue [active] 858619000474 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 858619000475 Divergent AAA domain; Region: AAA_4; pfam04326 858619000476 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 858619000477 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 858619000478 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 858619000479 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 858619000480 NAD binding site [chemical binding]; other site 858619000481 substrate binding site [chemical binding]; other site 858619000482 catalytic Zn binding site [ion binding]; other site 858619000483 tetramer interface [polypeptide binding]; other site 858619000484 structural Zn binding site [ion binding]; other site 858619000485 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 858619000486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000487 Walker A/P-loop; other site 858619000488 ATP binding site [chemical binding]; other site 858619000489 Q-loop/lid; other site 858619000490 ABC transporter signature motif; other site 858619000491 Walker B; other site 858619000492 D-loop; other site 858619000493 H-loop/switch region; other site 858619000494 Helix-turn-helix domain; Region: HTH_20; pfam12840 858619000495 putative DNA binding site [nucleotide binding]; other site 858619000496 putative Zn2+ binding site [ion binding]; other site 858619000497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619000498 S-adenosylmethionine binding site [chemical binding]; other site 858619000499 3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802 858619000500 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 858619000501 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 858619000502 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 858619000503 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 858619000504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 858619000505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619000506 dimer interface [polypeptide binding]; other site 858619000507 conserved gate region; other site 858619000508 putative PBP binding loops; other site 858619000509 ABC-ATPase subunit interface; other site 858619000510 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 858619000511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619000512 putative PBP binding loops; other site 858619000513 dimer interface [polypeptide binding]; other site 858619000514 ABC-ATPase subunit interface; other site 858619000515 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 858619000516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 858619000517 Walker A/P-loop; other site 858619000518 ATP binding site [chemical binding]; other site 858619000519 Q-loop/lid; other site 858619000520 ABC transporter signature motif; other site 858619000521 Walker B; other site 858619000522 D-loop; other site 858619000523 H-loop/switch region; other site 858619000524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 858619000525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 858619000526 Walker A/P-loop; other site 858619000527 ATP binding site [chemical binding]; other site 858619000528 Q-loop/lid; other site 858619000529 ABC transporter signature motif; other site 858619000530 Walker B; other site 858619000531 D-loop; other site 858619000532 H-loop/switch region; other site 858619000533 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 858619000534 Domain of unknown function (DUF222); Region: DUF222; pfam02720 858619000535 Domain of unknown function (DUF222); Region: DUF222; pfam02720 858619000536 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 858619000537 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 858619000538 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 858619000539 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 858619000540 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 858619000541 active site 858619000542 catalytic tetrad [active] 858619000543 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 858619000544 Orbivirus RNA-dependent RNA polymerase (VP1); Region: Orbi_VP1; pfam05788 858619000545 Methyltransferase domain; Region: Methyltransf_31; pfam13847 858619000546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619000547 S-adenosylmethionine binding site [chemical binding]; other site 858619000548 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 858619000549 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 858619000550 FAD binding domain; Region: FAD_binding_4; pfam01565 858619000551 diacylglycerol kinase; Reviewed; Region: PRK11914 858619000552 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 858619000553 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 858619000554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619000555 NAD(P) binding site [chemical binding]; other site 858619000556 active site 858619000557 Proline dehydrogenase; Region: Pro_dh; cl03282 858619000558 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 858619000559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 858619000560 NAD(P) binding site [chemical binding]; other site 858619000561 catalytic residues [active] 858619000562 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 858619000563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619000564 DNA-binding site [nucleotide binding]; DNA binding site 858619000565 FCD domain; Region: FCD; pfam07729 858619000566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000567 Q-loop/lid; other site 858619000568 ABC transporter signature motif; other site 858619000569 Walker B; other site 858619000570 D-loop; other site 858619000571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619000572 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 858619000573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 858619000574 Walker A/P-loop; other site 858619000575 ATP binding site [chemical binding]; other site 858619000576 Q-loop/lid; other site 858619000577 ABC transporter signature motif; other site 858619000578 Walker B; other site 858619000579 D-loop; other site 858619000580 H-loop/switch region; other site 858619000581 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 858619000582 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 858619000583 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 858619000584 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 858619000585 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 858619000586 putative homodimer interface [polypeptide binding]; other site 858619000587 putative homotetramer interface [polypeptide binding]; other site 858619000588 putative allosteric switch controlling residues; other site 858619000589 putative metal binding site [ion binding]; other site 858619000590 putative homodimer-homodimer interface [polypeptide binding]; other site 858619000591 MMPL family; Region: MMPL; pfam03176 858619000592 Domain of unknown function DUF302; Region: DUF302; cl01364 858619000593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619000594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619000595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 858619000596 dimerization interface [polypeptide binding]; other site 858619000597 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 858619000598 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 858619000599 D-pathway; other site 858619000600 Putative ubiquinol binding site [chemical binding]; other site 858619000601 Low-spin heme (heme b) binding site [chemical binding]; other site 858619000602 Putative water exit pathway; other site 858619000603 Binuclear center (heme o3/CuB) [ion binding]; other site 858619000604 K-pathway; other site 858619000605 Putative proton exit pathway; other site 858619000606 potential frameshift: common BLAST hit: gi|256390325|ref|YP_003111889.1| Triacylglycerol lipase 858619000607 Secretory lipase; Region: LIP; pfam03583 858619000608 Secretory lipase; Region: LIP; pfam03583 858619000609 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 858619000610 active site 858619000611 Predicted esterase [General function prediction only]; Region: COG0627 858619000612 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 858619000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000614 putative substrate translocation pore; other site 858619000615 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 858619000616 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619000617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619000618 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619000619 Transcriptional regulator [Transcription]; Region: LytR; COG1316 858619000620 CAAX protease self-immunity; Region: Abi; pfam02517 858619000621 Amidase; Region: Amidase; cl11426 858619000622 prephenate dehydratase; Provisional; Region: PRK11898 858619000623 Prephenate dehydratase; Region: PDT; pfam00800 858619000624 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 858619000625 putative L-Phe binding site [chemical binding]; other site 858619000626 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 858619000627 catalytic core [active] 858619000628 proline/glycine betaine transporter; Provisional; Region: PRK10642 858619000629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000630 putative substrate translocation pore; other site 858619000631 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 858619000632 Septum formation; Region: Septum_form; pfam13845 858619000633 Septum formation; Region: Septum_form; pfam13845 858619000634 seryl-tRNA synthetase; Provisional; Region: PRK05431 858619000635 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 858619000636 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 858619000637 dimer interface [polypeptide binding]; other site 858619000638 active site 858619000639 motif 1; other site 858619000640 motif 2; other site 858619000641 motif 3; other site 858619000642 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 858619000643 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 858619000644 putative acyl-acceptor binding pocket; other site 858619000645 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 858619000646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619000647 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 858619000648 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 858619000649 Class I ribonucleotide reductase; Region: RNR_I; cd01679 858619000650 active site 858619000651 dimer interface [polypeptide binding]; other site 858619000652 catalytic residues [active] 858619000653 effector binding site; other site 858619000654 R2 peptide binding site; other site 858619000655 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 858619000656 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 858619000657 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 858619000658 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 858619000659 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 858619000660 dimer interface [polypeptide binding]; other site 858619000661 putative radical transfer pathway; other site 858619000662 diiron center [ion binding]; other site 858619000663 tyrosyl radical; other site 858619000664 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 858619000665 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 858619000666 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 858619000667 putative NAD(P) binding site [chemical binding]; other site 858619000668 dimer interface [polypeptide binding]; other site 858619000669 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 858619000670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619000671 UDP-galactopyranose mutase; Region: GLF; pfam03275 858619000672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619000673 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 858619000674 dimer interface [polypeptide binding]; other site 858619000675 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 858619000676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619000677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619000678 acyl-activating enzyme (AAE) consensus motif; other site 858619000679 AMP binding site [chemical binding]; other site 858619000680 active site 858619000681 CoA binding site [chemical binding]; other site 858619000682 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619000683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619000684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000685 Walker A/P-loop; other site 858619000686 ATP binding site [chemical binding]; other site 858619000687 Q-loop/lid; other site 858619000688 ABC transporter signature motif; other site 858619000689 Walker B; other site 858619000690 D-loop; other site 858619000691 H-loop/switch region; other site 858619000692 ABC transporter; Region: ABC_tran; pfam00005 858619000693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619000694 Q-loop/lid; other site 858619000695 ABC transporter signature motif; other site 858619000696 Walker B; other site 858619000697 D-loop; other site 858619000698 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619000699 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619000700 intersubunit interface [polypeptide binding]; other site 858619000701 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619000702 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619000703 intersubunit interface [polypeptide binding]; other site 858619000704 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619000705 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619000706 FAD binding pocket [chemical binding]; other site 858619000707 FAD binding motif [chemical binding]; other site 858619000708 phosphate binding motif [ion binding]; other site 858619000709 NAD binding pocket [chemical binding]; other site 858619000710 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 858619000711 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 858619000712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619000713 Helix-turn-helix domain; Region: HTH_18; pfam12833 858619000714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619000715 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619000716 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619000717 intersubunit interface [polypeptide binding]; other site 858619000718 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 858619000719 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619000720 siderophore binding site; other site 858619000721 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 858619000722 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619000723 ABC-ATPase subunit interface; other site 858619000724 dimer interface [polypeptide binding]; other site 858619000725 putative PBP binding regions; other site 858619000726 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 858619000727 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619000728 ABC-ATPase subunit interface; other site 858619000729 dimer interface [polypeptide binding]; other site 858619000730 putative PBP binding regions; other site 858619000731 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619000732 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619000733 Walker A/P-loop; other site 858619000734 ATP binding site [chemical binding]; other site 858619000735 Q-loop/lid; other site 858619000736 ABC transporter signature motif; other site 858619000737 Walker B; other site 858619000738 D-loop; other site 858619000739 H-loop/switch region; other site 858619000740 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 858619000741 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 858619000742 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 858619000743 active site 858619000744 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 858619000745 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 858619000746 Putative esterase; Region: Esterase; pfam00756 858619000747 S-formylglutathione hydrolase; Region: PLN02442 858619000748 Haemolysin-III related; Region: HlyIII; pfam03006 858619000749 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 858619000750 Putative esterase; Region: Esterase; pfam00756 858619000751 S-formylglutathione hydrolase; Region: PLN02442 858619000752 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 858619000753 LGFP repeat; Region: LGFP; pfam08310 858619000754 LGFP repeat; Region: LGFP; pfam08310 858619000755 LGFP repeat; Region: LGFP; pfam08310 858619000756 LGFP repeat; Region: LGFP; pfam08310 858619000757 Predicted esterase [General function prediction only]; Region: COG0627 858619000758 S-formylglutathione hydrolase; Region: PLN02442 858619000759 Putative esterase; Region: Esterase; pfam00756 858619000760 S-formylglutathione hydrolase; Region: PLN02442 858619000761 LGFP repeat; Region: LGFP; pfam08310 858619000762 LGFP repeat; Region: LGFP; pfam08310 858619000763 LGFP repeat; Region: LGFP; pfam08310 858619000764 Putative esterase; Region: Esterase; pfam00756 858619000765 LGFP repeat; Region: LGFP; pfam08310 858619000766 LGFP repeat; Region: LGFP; pfam08310 858619000767 Cutinase; Region: Cutinase; pfam01083 858619000768 PE-PPE domain; Region: PE-PPE; pfam08237 858619000769 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 858619000770 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 858619000771 acyl-activating enzyme (AAE) consensus motif; other site 858619000772 active site 858619000773 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 858619000774 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 858619000775 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 858619000776 active site 858619000777 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 858619000778 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 858619000779 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 858619000780 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 858619000781 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 858619000782 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 858619000783 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 858619000784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000785 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 858619000786 putative substrate translocation pore; other site 858619000787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619000788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619000789 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 858619000790 putative dimerization interface [polypeptide binding]; other site 858619000791 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 858619000792 Predicted integral membrane protein [Function unknown]; Region: COG0392 858619000793 MMPL family; Region: MMPL; pfam03176 858619000794 MMPL family; Region: MMPL; pfam03176 858619000795 LabA_like proteins; Region: LabA_like; cd06167 858619000796 putative metal binding site [ion binding]; other site 858619000797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619000798 S-adenosylmethionine binding site [chemical binding]; other site 858619000799 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 858619000800 active site 858619000801 substrate-binding site [chemical binding]; other site 858619000802 metal-binding site [ion binding] 858619000803 GTP binding site [chemical binding]; other site 858619000804 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 858619000805 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 858619000806 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 858619000807 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 858619000808 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 858619000809 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 858619000810 catalytic tetrad [active] 858619000811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619000812 salt bridge; other site 858619000813 non-specific DNA binding site [nucleotide binding]; other site 858619000814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619000815 sequence-specific DNA binding site [nucleotide binding]; other site 858619000816 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 858619000817 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 858619000818 active site 858619000819 catalytic tetrad [active] 858619000820 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 858619000821 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 858619000822 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 858619000823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619000824 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 858619000825 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 858619000826 AsnC family; Region: AsnC_trans_reg; pfam01037 858619000827 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 858619000828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619000829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619000830 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 858619000831 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 858619000832 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 858619000833 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 858619000834 putative metal binding residues [ion binding]; other site 858619000835 signature motif; other site 858619000836 dimer interface [polypeptide binding]; other site 858619000837 active site 858619000838 polyP binding site; other site 858619000839 substrate binding site [chemical binding]; other site 858619000840 acceptor-phosphate pocket; other site 858619000841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 858619000842 Histidine kinase; Region: HisKA_3; pfam07730 858619000843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619000844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619000845 active site 858619000846 phosphorylation site [posttranslational modification] 858619000847 intermolecular recognition site; other site 858619000848 dimerization interface [polypeptide binding]; other site 858619000849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619000850 DNA binding residues [nucleotide binding] 858619000851 dimerization interface [polypeptide binding]; other site 858619000852 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 858619000853 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 858619000854 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 858619000855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619000856 substrate binding site [chemical binding]; other site 858619000857 oxyanion hole (OAH) forming residues; other site 858619000858 trimer interface [polypeptide binding]; other site 858619000859 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 858619000860 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 858619000861 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 858619000862 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 858619000863 dimer interface [polypeptide binding]; other site 858619000864 active site 858619000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619000866 S-adenosylmethionine binding site [chemical binding]; other site 858619000867 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 858619000868 benzoate transport; Region: 2A0115; TIGR00895 858619000869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000870 putative substrate translocation pore; other site 858619000871 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 858619000872 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 858619000873 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 858619000874 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 858619000875 Walker A/P-loop; other site 858619000876 ATP binding site [chemical binding]; other site 858619000877 Q-loop/lid; other site 858619000878 ABC transporter signature motif; other site 858619000879 Walker B; other site 858619000880 D-loop; other site 858619000881 H-loop/switch region; other site 858619000882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619000883 dimer interface [polypeptide binding]; other site 858619000884 conserved gate region; other site 858619000885 putative PBP binding loops; other site 858619000886 ABC-ATPase subunit interface; other site 858619000887 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 858619000888 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 858619000889 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 858619000890 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 858619000891 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 858619000892 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 858619000893 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 858619000894 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 858619000895 VanW like protein; Region: VanW; pfam04294 858619000896 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 858619000897 putative active site [active] 858619000898 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 858619000899 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 858619000900 phosphate binding site [ion binding]; other site 858619000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619000903 putative substrate translocation pore; other site 858619000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619000905 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 858619000906 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 858619000907 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 858619000908 4Fe-4S binding domain; Region: Fer4; cl02805 858619000909 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 858619000910 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 858619000911 Cysteine-rich domain; Region: CCG; pfam02754 858619000912 Cysteine-rich domain; Region: CCG; pfam02754 858619000913 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 858619000914 putative active site [active] 858619000915 Low molecular weight phosphatase family; Region: LMWPc; cl00105 858619000916 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 858619000917 active site 858619000918 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 858619000919 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 858619000920 trimer interface [polypeptide binding]; other site 858619000921 active site 858619000922 substrate binding site [chemical binding]; other site 858619000923 CoA binding site [chemical binding]; other site 858619000924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619000925 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619000926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 858619000927 putative active site [active] 858619000928 Low molecular weight phosphatase family; Region: LMWPc; cl00105 858619000929 active site 858619000930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 858619000931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 858619000932 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 858619000933 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 858619000934 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 858619000935 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 858619000936 active site 858619000937 Chain length determinant protein; Region: Wzz; pfam02706 858619000938 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 858619000939 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 858619000940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 858619000941 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 858619000942 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 858619000943 Bacterial sugar transferase; Region: Bac_transf; pfam02397 858619000944 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 858619000945 trimer interface [polypeptide binding]; other site 858619000946 active site 858619000947 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 858619000948 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 858619000949 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 858619000950 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 858619000951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619000952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619000953 active site 858619000954 phosphorylation site [posttranslational modification] 858619000955 intermolecular recognition site; other site 858619000956 dimerization interface [polypeptide binding]; other site 858619000957 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 858619000958 DNA binding residues [nucleotide binding] 858619000959 dimerization interface [polypeptide binding]; other site 858619000960 Histidine kinase; Region: HisKA_3; pfam07730 858619000961 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 858619000962 aminotransferase AlaT; Validated; Region: PRK09265 858619000963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619000964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619000965 homodimer interface [polypeptide binding]; other site 858619000966 catalytic residue [active] 858619000967 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 858619000968 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 858619000969 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 858619000970 nucleotide binding site [chemical binding]; other site 858619000971 NEF interaction site [polypeptide binding]; other site 858619000972 SBD interface [polypeptide binding]; other site 858619000973 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 858619000974 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 858619000975 dimer interface [polypeptide binding]; other site 858619000976 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 858619000977 chaperone protein DnaJ; Provisional; Region: PRK14279 858619000978 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 858619000979 HSP70 interaction site [polypeptide binding]; other site 858619000980 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 858619000981 Zn binding sites [ion binding]; other site 858619000982 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 858619000983 dimer interface [polypeptide binding]; other site 858619000984 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 858619000985 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 858619000986 DNA binding residues [nucleotide binding] 858619000987 putative dimer interface [polypeptide binding]; other site 858619000988 DoxX-like family; Region: DoxX_2; pfam13564 858619000989 Secretory lipase; Region: LIP; pfam03583 858619000990 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 858619000991 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 858619000992 NAD(P) binding site [chemical binding]; other site 858619000993 catalytic residues [active] 858619000994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 858619000995 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 858619000996 active site residue [active] 858619000997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 858619000998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 858619000999 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 858619001000 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 858619001001 NADP binding site [chemical binding]; other site 858619001002 dimer interface [polypeptide binding]; other site 858619001003 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 858619001004 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 858619001005 active site 858619001006 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 858619001007 GTP-binding protein LepA; Provisional; Region: PRK05433 858619001008 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 858619001009 G2 box; other site 858619001010 Switch I region; other site 858619001011 G3 box; other site 858619001012 Switch II region; other site 858619001013 GTP/Mg2+ binding site [chemical binding]; other site 858619001014 G4 box; other site 858619001015 G5 box; other site 858619001016 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 858619001017 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 858619001018 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 858619001019 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 858619001020 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 858619001021 putative hydrophobic ligand binding site [chemical binding]; other site 858619001022 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 858619001023 hydrophobic ligand binding site; other site 858619001024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619001025 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 858619001026 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 858619001027 putative catalytic site [active] 858619001028 putative metal binding site [ion binding]; other site 858619001029 putative phosphate binding site [ion binding]; other site 858619001030 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 858619001031 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 858619001032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619001033 Soluble P-type ATPase [General function prediction only]; Region: COG4087 858619001034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619001035 dimerization interface [polypeptide binding]; other site 858619001036 putative DNA binding site [nucleotide binding]; other site 858619001037 putative Zn2+ binding site [ion binding]; other site 858619001038 Plasmid replication protein; Region: Rep_2; pfam01719 858619001039 RNA helicase; Region: RNA_helicase; pfam00910 858619001040 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619001041 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 858619001042 catalytic residues [active] 858619001043 catalytic nucleophile [active] 858619001044 Recombinase; Region: Recombinase; pfam07508 858619001045 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 858619001046 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 858619001047 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 858619001048 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 858619001049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619001050 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 858619001051 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 858619001052 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 858619001053 Sulfate transporter family; Region: Sulfate_transp; pfam00916 858619001054 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 858619001055 Predicted amidohydrolase [General function prediction only]; Region: COG0388 858619001056 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 858619001057 putative active site [active] 858619001058 catalytic triad [active] 858619001059 putative dimer interface [polypeptide binding]; other site 858619001060 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619001061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 858619001062 dimer interface [polypeptide binding]; other site 858619001063 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619001064 ABC-ATPase subunit interface; other site 858619001065 dimer interface [polypeptide binding]; other site 858619001066 putative PBP binding regions; other site 858619001067 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619001068 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619001069 intersubunit interface [polypeptide binding]; other site 858619001070 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619001071 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619001072 Walker A/P-loop; other site 858619001073 ATP binding site [chemical binding]; other site 858619001074 Q-loop/lid; other site 858619001075 ABC transporter signature motif; other site 858619001076 Walker B; other site 858619001077 D-loop; other site 858619001078 H-loop/switch region; other site 858619001079 Cupin domain; Region: Cupin_2; cl17218 858619001080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619001081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619001082 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 858619001083 FAD binding pocket [chemical binding]; other site 858619001084 conserved FAD binding motif [chemical binding]; other site 858619001085 beta-alpha-beta structure motif; other site 858619001086 NAD binding pocket [chemical binding]; other site 858619001087 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 858619001088 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 858619001089 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 858619001090 active site 858619001091 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 858619001092 non-prolyl cis peptide bond; other site 858619001093 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619001094 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 858619001095 Clp amino terminal domain; Region: Clp_N; pfam02861 858619001096 Clp amino terminal domain; Region: Clp_N; pfam02861 858619001097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619001098 Walker A motif; other site 858619001099 ATP binding site [chemical binding]; other site 858619001100 Walker B motif; other site 858619001101 arginine finger; other site 858619001102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619001103 Walker A motif; other site 858619001104 ATP binding site [chemical binding]; other site 858619001105 Walker B motif; other site 858619001106 arginine finger; other site 858619001107 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 858619001108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 858619001109 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 858619001110 Walker A/P-loop; other site 858619001111 ATP binding site [chemical binding]; other site 858619001112 Q-loop/lid; other site 858619001113 ABC transporter signature motif; other site 858619001114 Walker B; other site 858619001115 D-loop; other site 858619001116 H-loop/switch region; other site 858619001117 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 858619001118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 858619001119 Histidine kinase; Region: HisKA_3; pfam07730 858619001120 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 858619001121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619001122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619001123 active site 858619001124 phosphorylation site [posttranslational modification] 858619001125 intermolecular recognition site; other site 858619001126 dimerization interface [polypeptide binding]; other site 858619001127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619001128 DNA binding residues [nucleotide binding] 858619001129 dimerization interface [polypeptide binding]; other site 858619001130 Predicted membrane protein [Function unknown]; Region: COG2860 858619001131 UPF0126 domain; Region: UPF0126; pfam03458 858619001132 UPF0126 domain; Region: UPF0126; pfam03458 858619001133 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 858619001134 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 858619001135 active site residue [active] 858619001136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 858619001137 active site residue [active] 858619001138 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 858619001139 HPr interaction site; other site 858619001140 glycerol kinase (GK) interaction site [polypeptide binding]; other site 858619001141 active site 858619001142 phosphorylation site [posttranslational modification] 858619001143 glycine dehydrogenase; Provisional; Region: PRK05367 858619001144 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 858619001145 tetramer interface [polypeptide binding]; other site 858619001146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619001147 catalytic residue [active] 858619001148 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 858619001149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619001150 catalytic residue [active] 858619001151 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 858619001152 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 858619001153 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 858619001154 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 858619001155 lipoyl attachment site [posttranslational modification]; other site 858619001156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619001157 active site 858619001158 YhhN-like protein; Region: YhhN; cl01505 858619001159 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 858619001160 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 858619001161 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 858619001162 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 858619001163 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 858619001164 active site 858619001165 intersubunit interface [polypeptide binding]; other site 858619001166 zinc binding site [ion binding]; other site 858619001167 Na+ binding site [ion binding]; other site 858619001168 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 858619001169 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 858619001170 putative catalytic site [active] 858619001171 putative phosphate binding site [ion binding]; other site 858619001172 putative metal binding site [ion binding]; other site 858619001173 Predicted membrane protein [Function unknown]; Region: COG4129 858619001174 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 858619001175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 858619001176 NMT1/THI5 like; Region: NMT1; pfam09084 858619001177 membrane-bound complex binding site; other site 858619001178 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 858619001179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619001180 dimer interface [polypeptide binding]; other site 858619001181 conserved gate region; other site 858619001182 putative PBP binding loops; other site 858619001183 ABC-ATPase subunit interface; other site 858619001184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001185 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 858619001186 Walker A/P-loop; other site 858619001187 ATP binding site [chemical binding]; other site 858619001188 Q-loop/lid; other site 858619001189 ABC transporter signature motif; other site 858619001190 Walker B; other site 858619001191 D-loop; other site 858619001192 H-loop/switch region; other site 858619001193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619001194 Coenzyme A binding pocket [chemical binding]; other site 858619001195 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 858619001196 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 858619001197 GDP-binding site [chemical binding]; other site 858619001198 ACT binding site; other site 858619001199 IMP binding site; other site 858619001200 Abi-like protein; Region: Abi_2; cl01988 858619001201 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619001202 MULE transposase domain; Region: MULE; pfam10551 858619001203 Bacterial PH domain; Region: DUF304; cl01348 858619001204 Bacterial PH domain; Region: DUF304; pfam03703 858619001205 Bacterial PH domain; Region: DUF304; pfam03703 858619001206 Bacterial PH domain; Region: DUF304; pfam03703 858619001207 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 858619001208 active site 858619001209 4-coumarate--CoA ligase; Region: PLN02246 858619001210 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 858619001211 acyl-activating enzyme (AAE) consensus motif; other site 858619001212 active site 858619001213 putative CoA binding site [chemical binding]; other site 858619001214 AMP binding site [chemical binding]; other site 858619001215 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 858619001216 Phosphotransferase enzyme family; Region: APH; pfam01636 858619001217 putative active site [active] 858619001218 putative substrate binding site [chemical binding]; other site 858619001219 ATP binding site [chemical binding]; other site 858619001220 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 858619001221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619001222 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619001223 active site 858619001224 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 858619001225 classical (c) SDRs; Region: SDR_c; cd05233 858619001226 NAD(P) binding site [chemical binding]; other site 858619001227 active site 858619001228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619001229 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619001230 catalytic core [active] 858619001231 4-coumarate--CoA ligase; Region: PLN02246 858619001232 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 858619001233 acyl-activating enzyme (AAE) consensus motif; other site 858619001234 active site 858619001235 putative CoA binding site [chemical binding]; other site 858619001236 AMP binding site [chemical binding]; other site 858619001237 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 858619001238 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 858619001239 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 858619001240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619001241 Coenzyme A binding pocket [chemical binding]; other site 858619001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 858619001243 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 858619001244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 858619001245 PAS domain; Region: PAS_9; pfam13426 858619001246 putative active site [active] 858619001247 heme pocket [chemical binding]; other site 858619001248 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 858619001249 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 858619001250 THF binding site; other site 858619001251 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 858619001252 substrate binding site [chemical binding]; other site 858619001253 THF binding site; other site 858619001254 zinc-binding site [ion binding]; other site 858619001255 OsmC-like protein; Region: OsmC; cl00767 858619001256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001257 ABC transporter signature motif; other site 858619001258 Walker B; other site 858619001259 D-loop; other site 858619001260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001261 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 858619001262 Walker A/P-loop; other site 858619001263 ATP binding site [chemical binding]; other site 858619001264 ABC transporter signature motif; other site 858619001265 Walker B; other site 858619001266 D-loop; other site 858619001267 H-loop/switch region; other site 858619001268 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 858619001269 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 858619001270 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 858619001271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619001272 ATP-grasp domain; Region: ATP-grasp; pfam02222 858619001273 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619001274 active site 858619001275 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 858619001276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619001277 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 858619001278 active site 858619001279 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 858619001280 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 858619001281 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 858619001282 active site residue [active] 858619001283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 858619001284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619001285 Coenzyme A binding pocket [chemical binding]; other site 858619001286 Cutinase; Region: Cutinase; pfam01083 858619001287 ferredoxin-NADP+ reductase; Region: PLN02852 858619001288 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619001289 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 858619001290 NAD binding site [chemical binding]; other site 858619001291 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 858619001292 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 858619001293 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 858619001294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619001295 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619001296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001297 Q-loop/lid; other site 858619001298 ABC transporter signature motif; other site 858619001299 Walker B; other site 858619001300 D-loop; other site 858619001301 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619001302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619001303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001304 Walker A/P-loop; other site 858619001305 ATP binding site [chemical binding]; other site 858619001306 Q-loop/lid; other site 858619001307 ABC transporter signature motif; other site 858619001308 Walker B; other site 858619001309 D-loop; other site 858619001310 H-loop/switch region; other site 858619001311 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 858619001312 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 858619001313 Active Sites [active] 858619001314 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 858619001315 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 858619001316 Active Sites [active] 858619001317 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 858619001318 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 858619001319 CysD dimerization site [polypeptide binding]; other site 858619001320 G1 box; other site 858619001321 putative GEF interaction site [polypeptide binding]; other site 858619001322 GTP/Mg2+ binding site [chemical binding]; other site 858619001323 Switch I region; other site 858619001324 G2 box; other site 858619001325 G3 box; other site 858619001326 Switch II region; other site 858619001327 G4 box; other site 858619001328 G5 box; other site 858619001329 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 858619001330 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 858619001331 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 858619001332 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 858619001333 putative active site [active] 858619001334 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 858619001335 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 858619001336 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 858619001337 propionate/acetate kinase; Provisional; Region: PRK12379 858619001338 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 858619001339 Catalytic domain of Protein Kinases; Region: PKc; cd00180 858619001340 active site 858619001341 ATP binding site [chemical binding]; other site 858619001342 substrate binding site [chemical binding]; other site 858619001343 activation loop (A-loop); other site 858619001344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 858619001345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 858619001346 substrate binding pocket [chemical binding]; other site 858619001347 membrane-bound complex binding site; other site 858619001348 hinge residues; other site 858619001349 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 858619001350 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 858619001351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001352 Walker A/P-loop; other site 858619001353 ATP binding site [chemical binding]; other site 858619001354 Q-loop/lid; other site 858619001355 ABC transporter signature motif; other site 858619001356 Walker B; other site 858619001357 D-loop; other site 858619001358 H-loop/switch region; other site 858619001359 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 858619001360 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 858619001361 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 858619001362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619001363 putative substrate translocation pore; other site 858619001364 Transcriptional regulators [Transcription]; Region: MarR; COG1846 858619001365 MarR family; Region: MarR_2; pfam12802 858619001366 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 858619001367 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 858619001368 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 858619001369 putative active site [active] 858619001370 catalytic site [active] 858619001371 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 858619001372 putative active site [active] 858619001373 catalytic site [active] 858619001374 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 858619001375 putative catalytic site [active] 858619001376 putative phosphate binding site [ion binding]; other site 858619001377 active site 858619001378 metal binding site A [ion binding]; metal-binding site 858619001379 DNA binding site [nucleotide binding] 858619001380 putative AP binding site [nucleotide binding]; other site 858619001381 putative metal binding site B [ion binding]; other site 858619001382 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 858619001383 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 858619001384 active site 858619001385 catalytic residues [active] 858619001386 metal binding site [ion binding]; metal-binding site 858619001387 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 858619001388 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 858619001389 carboxylate-amine ligase; Provisional; Region: PRK13517 858619001390 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 858619001391 2-isopropylmalate synthase; Validated; Region: PRK03739 858619001392 hypothetical protein; Provisional; Region: PRK07907 858619001393 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 858619001394 active site 858619001395 metal binding site [ion binding]; metal-binding site 858619001396 dimer interface [polypeptide binding]; other site 858619001397 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 858619001398 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 858619001399 ring oligomerisation interface [polypeptide binding]; other site 858619001400 ATP/Mg binding site [chemical binding]; other site 858619001401 stacking interactions; other site 858619001402 hinge regions; other site 858619001403 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 858619001404 Transcriptional regulators [Transcription]; Region: MarR; COG1846 858619001405 MarR family; Region: MarR_2; pfam12802 858619001406 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 858619001407 putative active site [active] 858619001408 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 858619001409 active site 858619001410 oxyanion hole [active] 858619001411 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 858619001412 dimer interface [polypeptide binding]; other site 858619001413 substrate binding site [chemical binding]; other site 858619001414 metal binding sites [ion binding]; metal-binding site 858619001415 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 858619001416 hydrophobic ligand binding site; other site 858619001417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 858619001418 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 858619001419 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 858619001420 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 858619001421 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 858619001422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619001423 active site 858619001424 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 858619001425 AAA ATPase domain; Region: AAA_16; pfam13191 858619001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619001427 Walker A motif; other site 858619001428 ATP binding site [chemical binding]; other site 858619001429 Walker B motif; other site 858619001430 arginine finger; other site 858619001431 Peptidase family M41; Region: Peptidase_M41; pfam01434 858619001432 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 858619001433 homodecamer interface [polypeptide binding]; other site 858619001434 GTP cyclohydrolase I; Provisional; Region: PLN03044 858619001435 active site 858619001436 putative catalytic site residues [active] 858619001437 zinc binding site [ion binding]; other site 858619001438 GTP-CH-I/GFRP interaction surface; other site 858619001439 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 858619001440 substrate binding pocket [chemical binding]; other site 858619001441 inhibitor binding site; inhibition site 858619001442 Dihydroneopterin aldolase; Region: FolB; smart00905 858619001443 active site 858619001444 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 858619001445 catalytic center binding site [active] 858619001446 ATP binding site [chemical binding]; other site 858619001447 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 858619001448 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 858619001449 Rossmann-like domain; Region: Rossmann-like; pfam10727 858619001450 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 858619001451 Pantoate-beta-alanine ligase; Region: PanC; cd00560 858619001452 pantoate--beta-alanine ligase; Region: panC; TIGR00018 858619001453 active site 858619001454 ATP-binding site [chemical binding]; other site 858619001455 pantoate-binding site; other site 858619001456 HXXH motif; other site 858619001457 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 858619001458 tetramerization interface [polypeptide binding]; other site 858619001459 active site 858619001460 Protein of unknown function (DUF503); Region: DUF503; pfam04456 858619001461 Predicted transcriptional regulator [Transcription]; Region: COG1959 858619001462 Transcriptional regulator; Region: Rrf2; cl17282 858619001463 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 858619001464 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 858619001465 heme-binding site [chemical binding]; other site 858619001466 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 858619001467 FAD binding pocket [chemical binding]; other site 858619001468 conserved FAD binding motif [chemical binding]; other site 858619001469 phosphate binding motif [ion binding]; other site 858619001470 beta-alpha-beta structure motif; other site 858619001471 NAD binding pocket [chemical binding]; other site 858619001472 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 858619001473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 858619001474 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 858619001475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 858619001476 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 858619001477 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 858619001478 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 858619001479 dimer interface [polypeptide binding]; other site 858619001480 putative anticodon binding site; other site 858619001481 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 858619001482 motif 1; other site 858619001483 dimer interface [polypeptide binding]; other site 858619001484 active site 858619001485 motif 2; other site 858619001486 motif 3; other site 858619001487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619001488 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619001489 active site 858619001490 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619001491 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619001492 active site 858619001493 acyl-CoA synthetase; Provisional; Region: PRK13382 858619001494 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619001495 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619001496 acyl-activating enzyme (AAE) consensus motif; other site 858619001497 AMP binding site [chemical binding]; other site 858619001498 active site 858619001499 CoA binding site [chemical binding]; other site 858619001500 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 858619001501 Clp amino terminal domain; Region: Clp_N; pfam02861 858619001502 Clp amino terminal domain; Region: Clp_N; pfam02861 858619001503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619001504 Walker A motif; other site 858619001505 ATP binding site [chemical binding]; other site 858619001506 Walker B motif; other site 858619001507 arginine finger; other site 858619001508 UvrB/uvrC motif; Region: UVR; pfam02151 858619001509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619001510 Walker A motif; other site 858619001511 ATP binding site [chemical binding]; other site 858619001512 Walker B motif; other site 858619001513 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 858619001514 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 858619001515 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 858619001516 minor groove reading motif; other site 858619001517 helix-hairpin-helix signature motif; other site 858619001518 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 858619001519 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 858619001520 active site clefts [active] 858619001521 zinc binding site [ion binding]; other site 858619001522 dimer interface [polypeptide binding]; other site 858619001523 DNA repair protein RadA; Provisional; Region: PRK11823 858619001524 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 858619001525 Walker A motif; other site 858619001526 ATP binding site [chemical binding]; other site 858619001527 Walker B motif; other site 858619001528 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 858619001529 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 858619001530 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 858619001531 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 858619001532 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619001533 active site 858619001534 HIGH motif; other site 858619001535 nucleotide binding site [chemical binding]; other site 858619001536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619001537 active site 858619001538 KMSKS motif; other site 858619001539 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 858619001540 benzoate transport; Region: 2A0115; TIGR00895 858619001541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619001542 putative substrate translocation pore; other site 858619001543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619001544 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 858619001545 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 858619001546 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 858619001547 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 858619001548 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 858619001549 phosphate binding site [ion binding]; other site 858619001550 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 858619001551 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 858619001552 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 858619001553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001554 Walker A/P-loop; other site 858619001555 ATP binding site [chemical binding]; other site 858619001556 Q-loop/lid; other site 858619001557 ABC transporter signature motif; other site 858619001558 Walker B; other site 858619001559 D-loop; other site 858619001560 H-loop/switch region; other site 858619001561 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619001562 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 858619001563 intersubunit interface [polypeptide binding]; other site 858619001564 Transcriptional regulators [Transcription]; Region: PurR; COG1609 858619001565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 858619001566 DNA binding site [nucleotide binding] 858619001567 domain linker motif; other site 858619001568 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 858619001569 putative dimerization interface [polypeptide binding]; other site 858619001570 putative ligand binding site [chemical binding]; other site 858619001571 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 858619001572 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 858619001573 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 858619001574 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 858619001575 active site 858619001576 homotetramer interface [polypeptide binding]; other site 858619001577 Uncharacterized conserved protein [Function unknown]; Region: COG2966 858619001578 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 858619001579 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 858619001580 classical (c) SDRs; Region: SDR_c; cd05233 858619001581 NAD(P) binding site [chemical binding]; other site 858619001582 active site 858619001583 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 858619001584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619001585 Coenzyme A binding pocket [chemical binding]; other site 858619001586 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 858619001587 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 858619001588 phytoene desaturase; Region: crtI_fam; TIGR02734 858619001589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619001590 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 858619001591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 858619001592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619001593 active site 858619001594 phosphorylation site [posttranslational modification] 858619001595 intermolecular recognition site; other site 858619001596 dimerization interface [polypeptide binding]; other site 858619001597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 858619001598 DNA binding site [nucleotide binding] 858619001599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 858619001600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 858619001601 dimerization interface [polypeptide binding]; other site 858619001602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 858619001603 dimer interface [polypeptide binding]; other site 858619001604 phosphorylation site [posttranslational modification] 858619001605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619001606 ATP binding site [chemical binding]; other site 858619001607 Mg2+ binding site [ion binding]; other site 858619001608 G-X-G motif; other site 858619001609 PGAP1-like protein; Region: PGAP1; pfam07819 858619001610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 858619001611 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 858619001612 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 858619001613 Lipase (class 2); Region: Lipase_2; pfam01674 858619001614 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 858619001615 nucleotide binding site/active site [active] 858619001616 HIT family signature motif; other site 858619001617 catalytic residue [active] 858619001618 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 858619001619 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 858619001620 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 858619001621 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 858619001622 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 858619001623 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 858619001624 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 858619001625 putative DNA binding site [nucleotide binding]; other site 858619001626 putative catalytic residues [active] 858619001627 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 858619001628 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 858619001629 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 858619001630 L-lactate permease; Region: Lactate_perm; cl00701 858619001631 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 858619001632 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 858619001633 active site 858619001634 substrate binding site [chemical binding]; other site 858619001635 FMN binding site [chemical binding]; other site 858619001636 putative catalytic residues [active] 858619001637 adenylosuccinate lyase; Region: purB; TIGR00928 858619001638 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 858619001639 tetramer interface [polypeptide binding]; other site 858619001640 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 858619001641 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 858619001642 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 858619001643 putative DNA binding site [nucleotide binding]; other site 858619001644 putative Zn2+ binding site [ion binding]; other site 858619001645 AsnC family; Region: AsnC_trans_reg; pfam01037 858619001646 pyruvate carboxylase; Reviewed; Region: PRK12999 858619001647 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619001648 ATP-grasp domain; Region: ATP-grasp_4; cl17255 858619001649 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 858619001650 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 858619001651 active site 858619001652 catalytic residues [active] 858619001653 metal binding site [ion binding]; metal-binding site 858619001654 homodimer binding site [polypeptide binding]; other site 858619001655 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 858619001656 carboxyltransferase (CT) interaction site; other site 858619001657 biotinylation site [posttranslational modification]; other site 858619001658 citrate synthase; Provisional; Region: PRK14033 858619001659 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 858619001660 dimer interface [polypeptide binding]; other site 858619001661 active site 858619001662 citrylCoA binding site [chemical binding]; other site 858619001663 oxalacetate/citrate binding site [chemical binding]; other site 858619001664 coenzyme A binding site [chemical binding]; other site 858619001665 catalytic triad [active] 858619001666 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 858619001667 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 858619001668 tetramer interface [polypeptide binding]; other site 858619001669 active site 858619001670 Mg2+/Mn2+ binding site [ion binding]; other site 858619001671 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 858619001672 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 858619001673 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 858619001674 Walker A/P-loop; other site 858619001675 ATP binding site [chemical binding]; other site 858619001676 Q-loop/lid; other site 858619001677 ABC transporter signature motif; other site 858619001678 Walker B; other site 858619001679 D-loop; other site 858619001680 H-loop/switch region; other site 858619001681 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 858619001682 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 858619001683 Walker A/P-loop; other site 858619001684 ATP binding site [chemical binding]; other site 858619001685 Q-loop/lid; other site 858619001686 ABC transporter signature motif; other site 858619001687 Walker B; other site 858619001688 D-loop; other site 858619001689 H-loop/switch region; other site 858619001690 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 858619001691 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 858619001692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619001693 dimer interface [polypeptide binding]; other site 858619001694 conserved gate region; other site 858619001695 putative PBP binding loops; other site 858619001696 ABC-ATPase subunit interface; other site 858619001697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 858619001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619001699 ABC-ATPase subunit interface; other site 858619001700 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 858619001701 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 858619001702 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 858619001703 ATP binding site [chemical binding]; other site 858619001704 active site 858619001705 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 858619001706 substrate binding site [chemical binding]; other site 858619001707 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 858619001708 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 858619001709 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 858619001710 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 858619001711 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 858619001712 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 858619001713 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 858619001714 putative active site [active] 858619001715 catalytic triad [active] 858619001716 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 858619001717 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 858619001718 dimerization interface [polypeptide binding]; other site 858619001719 ATP binding site [chemical binding]; other site 858619001720 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 858619001721 dimerization interface [polypeptide binding]; other site 858619001722 ATP binding site [chemical binding]; other site 858619001723 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 858619001724 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 858619001725 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 858619001726 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 858619001727 dimerization interface [polypeptide binding]; other site 858619001728 putative ATP binding site [chemical binding]; other site 858619001729 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 858619001730 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 858619001731 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 858619001732 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 858619001733 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 858619001734 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 858619001735 homodimer interface [polypeptide binding]; other site 858619001736 substrate-cofactor binding pocket; other site 858619001737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619001738 catalytic residue [active] 858619001739 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 858619001740 heme-binding site [chemical binding]; other site 858619001741 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 858619001742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 858619001743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 858619001744 DNA binding site [nucleotide binding] 858619001745 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 858619001746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 858619001747 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 858619001748 PBP superfamily domain; Region: PBP_like_2; cl17296 858619001749 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 858619001750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619001751 dimer interface [polypeptide binding]; other site 858619001752 conserved gate region; other site 858619001753 putative PBP binding loops; other site 858619001754 ABC-ATPase subunit interface; other site 858619001755 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 858619001756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619001757 dimer interface [polypeptide binding]; other site 858619001758 conserved gate region; other site 858619001759 putative PBP binding loops; other site 858619001760 ABC-ATPase subunit interface; other site 858619001761 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 858619001762 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 858619001763 Walker A/P-loop; other site 858619001764 ATP binding site [chemical binding]; other site 858619001765 Q-loop/lid; other site 858619001766 ABC transporter signature motif; other site 858619001767 Walker B; other site 858619001768 D-loop; other site 858619001769 H-loop/switch region; other site 858619001770 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 858619001771 AAA domain; Region: AAA_33; pfam13671 858619001772 ATP-binding site [chemical binding]; other site 858619001773 Gluconate-6-phosphate binding site [chemical binding]; other site 858619001774 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 858619001775 PhoU domain; Region: PhoU; pfam01895 858619001776 PhoU domain; Region: PhoU; pfam01895 858619001777 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 858619001778 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 858619001779 FMN binding site [chemical binding]; other site 858619001780 active site 858619001781 catalytic residues [active] 858619001782 substrate binding site [chemical binding]; other site 858619001783 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 858619001784 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 858619001785 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 858619001786 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 858619001787 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 858619001788 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 858619001789 PEP synthetase regulatory protein; Provisional; Region: PRK05339 858619001790 phosphoenolpyruvate synthase; Validated; Region: PRK06464 858619001791 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 858619001792 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 858619001793 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 858619001794 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 858619001795 aminodeoxychorismate synthase, fungal clade; Region: PabB-fungal; TIGR01823 858619001796 glutamine binding [chemical binding]; other site 858619001797 catalytic triad [active] 858619001798 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 858619001799 chorismate binding enzyme; Region: Chorismate_bind; cl10555 858619001800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 858619001801 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 858619001802 catalytic residue [active] 858619001803 serine O-acetyltransferase; Region: cysE; TIGR01172 858619001804 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 858619001805 trimer interface [polypeptide binding]; other site 858619001806 active site 858619001807 substrate binding site [chemical binding]; other site 858619001808 CoA binding site [chemical binding]; other site 858619001809 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 858619001810 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 858619001811 dimer interface [polypeptide binding]; other site 858619001812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619001813 catalytic residue [active] 858619001814 enoyl-CoA hydratase; Provisional; Region: PRK05862 858619001815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619001816 substrate binding site [chemical binding]; other site 858619001817 oxyanion hole (OAH) forming residues; other site 858619001818 trimer interface [polypeptide binding]; other site 858619001819 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 858619001820 GAF domain; Region: GAF; cl17456 858619001821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619001822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619001823 DNA binding residues [nucleotide binding] 858619001824 dimerization interface [polypeptide binding]; other site 858619001825 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 858619001826 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 858619001827 hinge; other site 858619001828 active site 858619001829 FtsX-like permease family; Region: FtsX; pfam02687 858619001830 FtsX-like permease family; Region: FtsX; pfam02687 858619001831 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619001832 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619001833 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 858619001834 substrate binding site [chemical binding]; other site 858619001835 THF binding site; other site 858619001836 zinc-binding site [ion binding]; other site 858619001837 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 858619001838 substrate binding site [chemical binding]; other site 858619001839 THF binding site; other site 858619001840 zinc-binding site [ion binding]; other site 858619001841 aminotransferase; Validated; Region: PRK07777 858619001842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619001843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619001844 homodimer interface [polypeptide binding]; other site 858619001845 catalytic residue [active] 858619001846 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 858619001847 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 858619001848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619001849 catalytic residue [active] 858619001850 Transcriptional regulators [Transcription]; Region: FadR; COG2186 858619001851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619001852 DNA-binding site [nucleotide binding]; DNA binding site 858619001853 FCD domain; Region: FCD; pfam07729 858619001854 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 858619001855 AAA domain; Region: AAA_33; pfam13671 858619001856 active site 858619001857 RibD C-terminal domain; Region: RibD_C; cl17279 858619001858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619001859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 858619001860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 858619001861 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 858619001862 carboxyltransferase (CT) interaction site; other site 858619001863 biotinylation site [posttranslational modification]; other site 858619001864 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 858619001865 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 858619001866 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 858619001867 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 858619001868 putative active site [active] 858619001869 Protein of unknown function, DUF606; Region: DUF606; cl01273 858619001870 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 858619001871 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 858619001872 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 858619001873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619001874 ATP binding site [chemical binding]; other site 858619001875 putative Mg++ binding site [ion binding]; other site 858619001876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619001877 nucleotide binding region [chemical binding]; other site 858619001878 ATP-binding site [chemical binding]; other site 858619001879 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 858619001880 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 858619001881 DinB superfamily; Region: DinB_2; pfam12867 858619001882 TrwC relaxase; Region: TrwC; pfam08751 858619001883 AAA domain; Region: AAA_30; pfam13604 858619001884 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619001885 MULE transposase domain; Region: MULE; pfam10551 858619001886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619001887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619001888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001889 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 858619001890 Walker A/P-loop; other site 858619001891 ATP binding site [chemical binding]; other site 858619001892 Q-loop/lid; other site 858619001893 ABC transporter signature motif; other site 858619001894 Walker B; other site 858619001895 D-loop; other site 858619001896 H-loop/switch region; other site 858619001897 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 858619001898 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619001899 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 858619001900 catalytic residues [active] 858619001901 catalytic nucleophile [active] 858619001902 Recombinase; Region: Recombinase; pfam07508 858619001903 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 858619001904 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 858619001905 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 858619001906 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 858619001907 DNA-binding site [nucleotide binding]; DNA binding site 858619001908 RNA-binding motif; other site 858619001909 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 858619001910 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 858619001911 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 858619001912 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 858619001913 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 858619001914 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 858619001915 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 858619001916 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619001917 catalytic residue [active] 858619001918 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 858619001919 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 858619001920 dimer interface [polypeptide binding]; other site 858619001921 active site 858619001922 citrylCoA binding site [chemical binding]; other site 858619001923 NADH binding [chemical binding]; other site 858619001924 cationic pore residues; other site 858619001925 oxalacetate/citrate binding site [chemical binding]; other site 858619001926 coenzyme A binding site [chemical binding]; other site 858619001927 catalytic triad [active] 858619001928 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 858619001929 putative OHCU decarboxylase; Provisional; Region: PRK13798 858619001930 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 858619001931 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 858619001932 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 858619001933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619001934 Walker A/P-loop; other site 858619001935 ATP binding site [chemical binding]; other site 858619001936 Q-loop/lid; other site 858619001937 ABC transporter signature motif; other site 858619001938 Walker B; other site 858619001939 D-loop; other site 858619001940 H-loop/switch region; other site 858619001941 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 858619001942 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619001943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619001944 non-specific DNA binding site [nucleotide binding]; other site 858619001945 salt bridge; other site 858619001946 sequence-specific DNA binding site [nucleotide binding]; other site 858619001947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 858619001948 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 858619001949 active site 858619001950 catalytic tetrad [active] 858619001951 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 858619001952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619001953 substrate binding site [chemical binding]; other site 858619001954 oxyanion hole (OAH) forming residues; other site 858619001955 trimer interface [polypeptide binding]; other site 858619001956 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 858619001957 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619001958 Soluble P-type ATPase [General function prediction only]; Region: COG4087 858619001959 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 858619001960 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 858619001961 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 858619001962 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 858619001963 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 858619001964 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 858619001965 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 858619001966 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 858619001967 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 858619001968 Na binding site [ion binding]; other site 858619001969 Protein of unknown function, DUF485; Region: DUF485; pfam04341 858619001970 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 858619001971 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 858619001972 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 858619001973 folate binding site [chemical binding]; other site 858619001974 NADP+ binding site [chemical binding]; other site 858619001975 thymidylate synthase; Reviewed; Region: thyA; PRK01827 858619001976 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 858619001977 dimerization interface [polypeptide binding]; other site 858619001978 active site 858619001979 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 858619001980 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 858619001981 active site 858619001982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619001983 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 858619001984 hydroxyglutarate oxidase; Provisional; Region: PRK11728 858619001985 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 858619001986 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 858619001987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619001988 S-adenosylmethionine binding site [chemical binding]; other site 858619001989 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 858619001990 Transcriptional regulators [Transcription]; Region: MarR; COG1846 858619001991 MarR family; Region: MarR; pfam01047 858619001992 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 858619001993 DNA photolyase; Region: DNA_photolyase; pfam00875 858619001994 ferrochelatase; Reviewed; Region: hemH; PRK00035 858619001995 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 858619001996 C-terminal domain interface [polypeptide binding]; other site 858619001997 active site 858619001998 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 858619001999 active site 858619002000 N-terminal domain interface [polypeptide binding]; other site 858619002001 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 858619002002 Fasciclin domain; Region: Fasciclin; pfam02469 858619002003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619002004 NADH(P)-binding; Region: NAD_binding_10; pfam13460 858619002005 NAD(P) binding site [chemical binding]; other site 858619002006 active site 858619002007 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 858619002008 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 858619002009 putative hydrophobic ligand binding site [chemical binding]; other site 858619002010 MMPL family; Region: MMPL; pfam03176 858619002011 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 858619002012 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 858619002013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619002014 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 858619002015 Walker A/P-loop; other site 858619002016 ATP binding site [chemical binding]; other site 858619002017 Q-loop/lid; other site 858619002018 ABC transporter signature motif; other site 858619002019 Walker B; other site 858619002020 D-loop; other site 858619002021 H-loop/switch region; other site 858619002022 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 858619002023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619002024 ABC-ATPase subunit interface; other site 858619002025 dimer interface [polypeptide binding]; other site 858619002026 putative PBP binding regions; other site 858619002027 FOG: WD40-like repeat [Function unknown]; Region: COG1520 858619002028 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 858619002029 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619002030 intersubunit interface [polypeptide binding]; other site 858619002031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619002032 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 858619002033 ATP binding site [chemical binding]; other site 858619002034 putative Mg++ binding site [ion binding]; other site 858619002035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619002036 nucleotide binding region [chemical binding]; other site 858619002037 DEAD/H associated; Region: DEAD_assoc; pfam08494 858619002038 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 858619002039 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 858619002040 Walker A/P-loop; other site 858619002041 ATP binding site [chemical binding]; other site 858619002042 Q-loop/lid; other site 858619002043 ABC transporter signature motif; other site 858619002044 Walker B; other site 858619002045 D-loop; other site 858619002046 H-loop/switch region; other site 858619002047 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 858619002048 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 858619002049 putative DNA binding site [nucleotide binding]; other site 858619002050 catalytic residue [active] 858619002051 putative H2TH interface [polypeptide binding]; other site 858619002052 putative catalytic residues [active] 858619002053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 858619002054 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 858619002055 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 858619002056 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 858619002057 active site 858619002058 dimer interface [polypeptide binding]; other site 858619002059 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 858619002060 dimer interface [polypeptide binding]; other site 858619002061 active site 858619002062 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 858619002063 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 858619002064 active site 858619002065 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 858619002066 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 858619002067 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 858619002068 active site 858619002069 catalytic site [active] 858619002070 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 858619002071 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 858619002072 homodimer interface [polypeptide binding]; other site 858619002073 ADP-binding pocket [chemical binding]; other site 858619002074 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 858619002075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 858619002076 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 858619002077 dimer interface [polypeptide binding]; other site 858619002078 N-terminal domain interface [polypeptide binding]; other site 858619002079 sulfate 1 binding site; other site 858619002080 glycogen branching enzyme; Provisional; Region: PRK05402 858619002081 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 858619002082 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 858619002083 active site 858619002084 catalytic site [active] 858619002085 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 858619002086 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 858619002087 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 858619002088 active site 858619002089 catalytic site [active] 858619002090 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 858619002091 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 858619002092 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 858619002093 active site 858619002094 peptide chain release factor 2; Validated; Region: prfB; PRK00578 858619002095 This domain is found in peptide chain release factors; Region: PCRF; smart00937 858619002096 RF-1 domain; Region: RF-1; pfam00472 858619002097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619002098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619002099 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 858619002100 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 858619002101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 858619002102 Walker A/P-loop; other site 858619002103 ATP binding site [chemical binding]; other site 858619002104 ABC transporter; Region: ABC_tran; pfam00005 858619002105 Q-loop/lid; other site 858619002106 ABC transporter signature motif; other site 858619002107 Walker B; other site 858619002108 D-loop; other site 858619002109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619002110 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 858619002111 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 858619002112 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 858619002113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619002114 Walker A/P-loop; other site 858619002115 ATP binding site [chemical binding]; other site 858619002116 Q-loop/lid; other site 858619002117 ABC transporter signature motif; other site 858619002118 Walker B; other site 858619002119 D-loop; other site 858619002120 H-loop/switch region; other site 858619002121 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 858619002122 FtsX-like permease family; Region: FtsX; pfam02687 858619002123 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 858619002124 SmpB-tmRNA interface; other site 858619002125 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 858619002126 MarR family; Region: MarR_2; pfam12802 858619002127 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 858619002128 active site 858619002129 catalytic triad [active] 858619002130 oxyanion hole [active] 858619002131 Cutinase; Region: Cutinase; pfam01083 858619002132 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 858619002133 acyl-CoA synthetase; Validated; Region: PRK08162 858619002134 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 858619002135 acyl-activating enzyme (AAE) consensus motif; other site 858619002136 putative active site [active] 858619002137 AMP binding site [chemical binding]; other site 858619002138 putative CoA binding site [chemical binding]; other site 858619002139 Protein of unknown function (DUF998); Region: DUF998; pfam06197 858619002140 Transcriptional regulators [Transcription]; Region: FadR; COG2186 858619002141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619002142 DNA-binding site [nucleotide binding]; DNA binding site 858619002143 FCD domain; Region: FCD; pfam07729 858619002144 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 858619002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619002146 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 858619002147 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 858619002148 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 858619002149 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 858619002150 catalytic residues [active] 858619002151 Predicted membrane protein [Function unknown]; Region: COG3212 858619002152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 858619002153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619002154 active site 858619002155 phosphorylation site [posttranslational modification] 858619002156 intermolecular recognition site; other site 858619002157 dimerization interface [polypeptide binding]; other site 858619002158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 858619002159 DNA binding site [nucleotide binding] 858619002160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 858619002161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 858619002162 dimer interface [polypeptide binding]; other site 858619002163 phosphorylation site [posttranslational modification] 858619002164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619002165 ATP binding site [chemical binding]; other site 858619002166 Mg2+ binding site [ion binding]; other site 858619002167 G-X-G motif; other site 858619002168 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 858619002169 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 858619002170 substrate binding pocket [chemical binding]; other site 858619002171 catalytic triad [active] 858619002172 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 858619002173 putative active site [active] 858619002174 redox center [active] 858619002175 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 858619002176 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 858619002177 catalytic residues [active] 858619002178 H+ Antiporter protein; Region: 2A0121; TIGR00900 858619002179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619002180 putative substrate translocation pore; other site 858619002181 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 858619002182 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 858619002183 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 858619002184 Class I ribonucleotide reductase; Region: RNR_I; cd01679 858619002185 active site 858619002186 dimer interface [polypeptide binding]; other site 858619002187 catalytic residues [active] 858619002188 effector binding site; other site 858619002189 R2 peptide binding site; other site 858619002190 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 858619002191 Ferritin-like domain; Region: Ferritin; pfam00210 858619002192 ferroxidase diiron center [ion binding]; other site 858619002193 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 858619002194 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 858619002195 dimer interface [polypeptide binding]; other site 858619002196 putative radical transfer pathway; other site 858619002197 diiron center [ion binding]; other site 858619002198 tyrosyl radical; other site 858619002199 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 858619002200 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 858619002201 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 858619002202 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 858619002203 D-pathway; other site 858619002204 Putative ubiquinol binding site [chemical binding]; other site 858619002205 Low-spin heme (heme b) binding site [chemical binding]; other site 858619002206 Putative water exit pathway; other site 858619002207 Binuclear center (heme o3/CuB) [ion binding]; other site 858619002208 K-pathway; other site 858619002209 Putative proton exit pathway; other site 858619002210 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 858619002211 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 858619002212 phosphoserine phosphatase SerB; Region: serB; TIGR00338 858619002213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619002214 active site 858619002215 motif I; other site 858619002216 motif II; other site 858619002217 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 858619002218 dimer interface [polypeptide binding]; other site 858619002219 putative active site [active] 858619002220 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619002221 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 858619002222 acyl-activating enzyme (AAE) consensus motif; other site 858619002223 AMP binding site [chemical binding]; other site 858619002224 active site 858619002225 CoA binding site [chemical binding]; other site 858619002226 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 858619002227 DEAD/DEAH box helicase; Region: DEAD; pfam00270 858619002228 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 858619002229 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 858619002230 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 858619002231 active site 858619002232 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 858619002233 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 858619002234 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 858619002235 putative active site pocket [active] 858619002236 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 858619002237 cleavage site 858619002238 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 858619002239 glutamate racemase; Provisional; Region: PRK00865 858619002240 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 858619002241 ribonuclease PH; Reviewed; Region: rph; PRK00173 858619002242 Ribonuclease PH; Region: RNase_PH_bact; cd11362 858619002243 hexamer interface [polypeptide binding]; other site 858619002244 active site 858619002245 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 858619002246 active site 858619002247 dimerization interface [polypeptide binding]; other site 858619002248 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 858619002249 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 858619002250 metal binding site [ion binding]; metal-binding site 858619002251 putative dimer interface [polypeptide binding]; other site 858619002252 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 858619002253 Glucitol operon activator protein (GutM); Region: GutM; cl01890 858619002254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619002255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619002256 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 858619002257 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 858619002258 D-pathway; other site 858619002259 Putative ubiquinol binding site [chemical binding]; other site 858619002260 Low-spin heme (heme b) binding site [chemical binding]; other site 858619002261 Putative water exit pathway; other site 858619002262 Binuclear center (heme o3/CuB) [ion binding]; other site 858619002263 K-pathway; other site 858619002264 Putative proton exit pathway; other site 858619002265 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 858619002266 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 858619002267 catalytic triad [active] 858619002268 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 858619002269 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 858619002270 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 858619002271 Predicted membrane protein [Function unknown]; Region: COG1950 858619002272 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 858619002273 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 858619002274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 858619002275 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 858619002276 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 858619002277 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 858619002278 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619002279 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 858619002280 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 858619002281 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619002282 Walker A/P-loop; other site 858619002283 ATP binding site [chemical binding]; other site 858619002284 Q-loop/lid; other site 858619002285 ABC transporter signature motif; other site 858619002286 Walker B; other site 858619002287 D-loop; other site 858619002288 H-loop/switch region; other site 858619002289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619002290 ABC-ATPase subunit interface; other site 858619002291 dimer interface [polypeptide binding]; other site 858619002292 putative PBP binding regions; other site 858619002293 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619002294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619002295 ABC-ATPase subunit interface; other site 858619002296 dimer interface [polypeptide binding]; other site 858619002297 putative PBP binding regions; other site 858619002298 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619002299 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619002300 intersubunit interface [polypeptide binding]; other site 858619002301 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619002302 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619002303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619002304 Walker A/P-loop; other site 858619002305 ATP binding site [chemical binding]; other site 858619002306 Q-loop/lid; other site 858619002307 ABC transporter signature motif; other site 858619002308 Walker B; other site 858619002309 D-loop; other site 858619002310 H-loop/switch region; other site 858619002311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619002312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619002313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619002314 Walker A/P-loop; other site 858619002315 ATP binding site [chemical binding]; other site 858619002316 Q-loop/lid; other site 858619002317 ABC transporter signature motif; other site 858619002318 Walker B; other site 858619002319 D-loop; other site 858619002320 H-loop/switch region; other site 858619002321 Helix-turn-helix domain; Region: HTH_18; pfam12833 858619002322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619002323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619002324 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 858619002325 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619002326 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619002327 FAD binding pocket [chemical binding]; other site 858619002328 FAD binding motif [chemical binding]; other site 858619002329 phosphate binding motif [ion binding]; other site 858619002330 NAD binding pocket [chemical binding]; other site 858619002331 O-methyltransferase; Region: Methyltransf_2; pfam00891 858619002332 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619002333 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619002334 intersubunit interface [polypeptide binding]; other site 858619002335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619002336 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619002337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619002338 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 858619002339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619002340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619002341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619002342 salt bridge; other site 858619002343 non-specific DNA binding site [nucleotide binding]; other site 858619002344 sequence-specific DNA binding site [nucleotide binding]; other site 858619002345 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619002346 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619002347 FAD binding pocket [chemical binding]; other site 858619002348 FAD binding motif [chemical binding]; other site 858619002349 phosphate binding motif [ion binding]; other site 858619002350 NAD binding pocket [chemical binding]; other site 858619002351 O-methyltransferase; Region: Methyltransf_2; pfam00891 858619002352 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 858619002353 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 858619002354 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 858619002355 putative active site [active] 858619002356 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 858619002357 Protein of unknown function DUF86; Region: DUF86; cl01031 858619002358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 858619002359 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 858619002360 active site 858619002361 NTP binding site [chemical binding]; other site 858619002362 metal binding triad [ion binding]; metal-binding site 858619002363 antibiotic binding site [chemical binding]; other site 858619002364 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 858619002365 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619002366 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619002367 intersubunit interface [polypeptide binding]; other site 858619002368 Helix-turn-helix domain; Region: HTH_18; pfam12833 858619002369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619002370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619002371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619002372 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619002373 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619002374 FAD binding pocket [chemical binding]; other site 858619002375 FAD binding motif [chemical binding]; other site 858619002376 phosphate binding motif [ion binding]; other site 858619002377 NAD binding pocket [chemical binding]; other site 858619002378 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 858619002379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619002380 Transposase; Region: HTH_Tnp_1; pfam01527 858619002381 putative transposase OrfB; Reviewed; Region: PHA02517 858619002382 HTH-like domain; Region: HTH_21; pfam13276 858619002383 Integrase core domain; Region: rve; pfam00665 858619002384 Integrase core domain; Region: rve_3; pfam13683 858619002385 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619002386 MULE transposase domain; Region: MULE; pfam10551 858619002387 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 858619002388 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 858619002389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619002390 ATP binding site [chemical binding]; other site 858619002391 putative Mg++ binding site [ion binding]; other site 858619002392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619002393 nucleotide binding region [chemical binding]; other site 858619002394 ATP-binding site [chemical binding]; other site 858619002395 Protein of unknown function (DUF554); Region: DUF554; cl00784 858619002396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619002397 S-adenosylmethionine binding site [chemical binding]; other site 858619002398 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 858619002399 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 858619002400 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619002401 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 858619002402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619002403 motif II; other site 858619002404 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 858619002405 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 858619002406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619002407 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 858619002408 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 858619002409 NAD(P) binding site [chemical binding]; other site 858619002410 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 858619002411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619002412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619002413 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 858619002414 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 858619002415 catalytic site [active] 858619002416 putative active site [active] 858619002417 putative substrate binding site [chemical binding]; other site 858619002418 dimer interface [polypeptide binding]; other site 858619002419 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 858619002420 classical (c) SDRs; Region: SDR_c; cd05233 858619002421 NAD(P) binding site [chemical binding]; other site 858619002422 active site 858619002423 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 858619002424 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 858619002425 transmembrane helices; other site 858619002426 Predicted membrane protein [Function unknown]; Region: COG4763 858619002427 Acyltransferase family; Region: Acyl_transf_3; pfam01757 858619002428 OpgC protein; Region: OpgC_C; cl17858 858619002429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619002430 Coenzyme A binding pocket [chemical binding]; other site 858619002431 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 858619002432 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 858619002433 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 858619002434 dimer interface [polypeptide binding]; other site 858619002435 ssDNA binding site [nucleotide binding]; other site 858619002436 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 858619002437 tetramer (dimer of dimers) interface [polypeptide binding]; other site 858619002438 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 858619002439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619002440 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619002441 ABC transporter; Region: ABC_tran_2; pfam12848 858619002442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619002443 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 858619002444 active site 858619002445 hypothetical protein; Provisional; Region: PRK10621 858619002446 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 858619002447 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 858619002448 apolar tunnel; other site 858619002449 heme binding site [chemical binding]; other site 858619002450 dimerization interface [polypeptide binding]; other site 858619002451 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 858619002452 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 858619002453 Zn binding site [ion binding]; other site 858619002454 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 858619002455 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 858619002456 active site 858619002457 DNA binding site [nucleotide binding] 858619002458 Int/Topo IB signature motif; other site 858619002459 Integrase core domain; Region: rve_3; cl15866 858619002460 HTH-like domain; Region: HTH_21; pfam13276 858619002461 Integrase core domain; Region: rve; pfam00665 858619002462 potential frameshift: common BLAST hit: gi|256832661|ref|YP_003161388.1| transposase IS204/IS1001/IS1096/IS1165 family protein 858619002463 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619002464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619002465 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619002466 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 858619002467 pyruvate dehydrogenase; Provisional; Region: PRK06546 858619002468 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 858619002469 PYR/PP interface [polypeptide binding]; other site 858619002470 tetramer interface [polypeptide binding]; other site 858619002471 dimer interface [polypeptide binding]; other site 858619002472 TPP binding site [chemical binding]; other site 858619002473 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 858619002474 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 858619002475 TPP-binding site [chemical binding]; other site 858619002476 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619002477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619002478 non-specific DNA binding site [nucleotide binding]; other site 858619002479 salt bridge; other site 858619002480 sequence-specific DNA binding site [nucleotide binding]; other site 858619002481 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 858619002482 RecT family; Region: RecT; pfam03837 858619002483 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 858619002484 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 858619002485 dimer interface [polypeptide binding]; other site 858619002486 ssDNA binding site [nucleotide binding]; other site 858619002487 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 858619002488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 858619002489 Endodeoxyribonuclease RusA; Region: RusA; cl01885 858619002490 DNA polymerase III subunit beta; Validated; Region: PRK07761 858619002491 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 858619002492 putative DNA binding surface [nucleotide binding]; other site 858619002493 dimer interface [polypeptide binding]; other site 858619002494 beta-clamp/clamp loader binding surface; other site 858619002495 beta-clamp/translesion DNA polymerase binding surface; other site 858619002496 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 858619002497 trimer interface [polypeptide binding]; other site 858619002498 active site 858619002499 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 858619002500 catalytic residues [active] 858619002501 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 858619002502 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 858619002503 dimer interface [polypeptide binding]; other site 858619002504 putative radical transfer pathway; other site 858619002505 diiron center [ion binding]; other site 858619002506 tyrosyl radical; other site 858619002507 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 858619002508 Thymidylate synthase complementing protein; Region: Thy1; cl03630 858619002509 ParB-like nuclease domain; Region: ParBc; pfam02195 858619002510 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 858619002511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 858619002512 DNA binding residues [nucleotide binding] 858619002513 Phage terminase large subunit; Region: Terminase_3; cl12054 858619002514 Terminase-like family; Region: Terminase_6; pfam03237 858619002515 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 858619002516 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 858619002517 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 858619002518 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 858619002519 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 858619002520 Minor capsid protein; Region: Minor_capsid_2; pfam11114 858619002521 tape measure domain; Region: tape_meas_nterm; TIGR02675 858619002522 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 858619002523 NlpC/P60 family; Region: NLPC_P60; cl17555 858619002524 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 858619002525 amidase catalytic site [active] 858619002526 Zn binding residues [ion binding]; other site 858619002527 substrate binding site [chemical binding]; other site 858619002528 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 858619002529 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 858619002530 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 858619002531 active site 858619002532 trigger factor; Provisional; Region: tig; PRK01490 858619002533 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 858619002534 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 858619002535 Clp protease; Region: CLP_protease; pfam00574 858619002536 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 858619002537 oligomer interface [polypeptide binding]; other site 858619002538 active site residues [active] 858619002539 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 858619002540 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 858619002541 oligomer interface [polypeptide binding]; other site 858619002542 active site residues [active] 858619002543 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 858619002544 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 858619002545 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 858619002546 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 858619002547 dimer interface [polypeptide binding]; other site 858619002548 active site 858619002549 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 858619002550 Coenzyme A transferase; Region: CoA_trans; cl17247 858619002551 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 858619002552 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 858619002553 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 858619002554 putative active site [active] 858619002555 putative substrate binding site [chemical binding]; other site 858619002556 putative cosubstrate binding site; other site 858619002557 catalytic site [active] 858619002558 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 858619002559 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 858619002560 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 858619002561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619002562 Walker A motif; other site 858619002563 ATP binding site [chemical binding]; other site 858619002564 Walker B motif; other site 858619002565 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 858619002566 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 858619002567 malate dehydrogenase; Provisional; Region: PRK05442 858619002568 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 858619002569 NAD(P) binding site [chemical binding]; other site 858619002570 LDH/MDH dimer interface [polypeptide binding]; other site 858619002571 substrate binding site [chemical binding]; other site 858619002572 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 858619002573 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 858619002574 substrate binding pocket [chemical binding]; other site 858619002575 xanthine permease; Region: pbuX; TIGR03173 858619002576 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 858619002577 mevalonate kinase; Region: mevalon_kin; TIGR00549 858619002578 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 858619002579 diphosphomevalonate decarboxylase; Region: PLN02407 858619002580 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 858619002581 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 858619002582 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 858619002583 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 858619002584 homotetramer interface [polypeptide binding]; other site 858619002585 FMN binding site [chemical binding]; other site 858619002586 homodimer contacts [polypeptide binding]; other site 858619002587 putative active site [active] 858619002588 putative substrate binding site [chemical binding]; other site 858619002589 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 858619002590 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 858619002591 active site 858619002592 metal binding site [ion binding]; metal-binding site 858619002593 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 858619002594 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 858619002595 NAD(P) binding site [chemical binding]; other site 858619002596 catalytic residues [active] 858619002597 AzlC protein; Region: AzlC; pfam03591 858619002598 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619002599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619002600 non-specific DNA binding site [nucleotide binding]; other site 858619002601 salt bridge; other site 858619002602 sequence-specific DNA binding site [nucleotide binding]; other site 858619002603 Cupin domain; Region: Cupin_2; pfam07883 858619002604 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 858619002605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619002606 active site 858619002607 HIGH motif; other site 858619002608 nucleotide binding site [chemical binding]; other site 858619002609 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 858619002610 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 858619002611 active site 858619002612 KMSKS motif; other site 858619002613 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 858619002614 tRNA binding surface [nucleotide binding]; other site 858619002615 anticodon binding site; other site 858619002616 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 858619002617 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 858619002618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 858619002619 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 858619002620 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 858619002621 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 858619002622 Predicted flavoprotein [General function prediction only]; Region: COG0431 858619002623 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 858619002624 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 858619002625 active site 858619002626 multimer interface [polypeptide binding]; other site 858619002627 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 858619002628 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 858619002629 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 858619002630 homodimer interface [polypeptide binding]; other site 858619002631 oligonucleotide binding site [chemical binding]; other site 858619002632 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 858619002633 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 858619002634 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 858619002635 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619002636 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 858619002637 siderophore binding site; other site 858619002638 GTPase CgtA; Reviewed; Region: obgE; PRK12296 858619002639 GTP1/OBG; Region: GTP1_OBG; pfam01018 858619002640 Obg GTPase; Region: Obg; cd01898 858619002641 G1 box; other site 858619002642 GTP/Mg2+ binding site [chemical binding]; other site 858619002643 Switch I region; other site 858619002644 G2 box; other site 858619002645 G3 box; other site 858619002646 Switch II region; other site 858619002647 G4 box; other site 858619002648 G5 box; other site 858619002649 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 858619002650 gamma-glutamyl kinase; Provisional; Region: PRK05429 858619002651 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 858619002652 nucleotide binding site [chemical binding]; other site 858619002653 homotetrameric interface [polypeptide binding]; other site 858619002654 putative phosphate binding site [ion binding]; other site 858619002655 putative allosteric binding site; other site 858619002656 PUA domain; Region: PUA; pfam01472 858619002657 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 858619002658 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 858619002659 putative catalytic cysteine [active] 858619002660 YwiC-like protein; Region: YwiC; pfam14256 858619002661 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 858619002662 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 858619002663 active site 858619002664 (T/H)XGH motif; other site 858619002665 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 858619002666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619002667 catalytic core [active] 858619002668 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 858619002669 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 858619002670 Competence protein; Region: Competence; pfam03772 858619002671 hypothetical protein; Validated; Region: PRK05629 858619002672 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 858619002673 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 858619002674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619002675 putative substrate translocation pore; other site 858619002676 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 858619002677 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 858619002678 TPP-binding site [chemical binding]; other site 858619002679 heterodimer interface [polypeptide binding]; other site 858619002680 tetramer interface [polypeptide binding]; other site 858619002681 phosphorylation loop region [posttranslational modification] 858619002682 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 858619002683 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 858619002684 alpha subunit interface [polypeptide binding]; other site 858619002685 TPP binding site [chemical binding]; other site 858619002686 heterodimer interface [polypeptide binding]; other site 858619002687 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 858619002688 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 858619002689 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 858619002690 E3 interaction surface; other site 858619002691 lipoyl attachment site [posttranslational modification]; other site 858619002692 e3 binding domain; Region: E3_binding; pfam02817 858619002693 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 858619002694 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 858619002695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619002696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619002697 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 858619002698 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 858619002699 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 858619002700 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 858619002701 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 858619002702 NAD(P) binding site [chemical binding]; other site 858619002703 catalytic residues [active] 858619002704 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 858619002705 CoA-transferase family III; Region: CoA_transf_3; pfam02515 858619002706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619002707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619002708 active site 858619002709 Transcriptional regulator [Transcription]; Region: IclR; COG1414 858619002710 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 858619002711 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 858619002712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619002713 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619002714 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 858619002715 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 858619002716 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 858619002717 DctM-like transporters; Region: DctM; pfam06808 858619002718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619002719 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 858619002720 putative substrate translocation pore; other site 858619002721 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 858619002722 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 858619002723 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 858619002724 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 858619002725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619002726 inhibitor-cofactor binding pocket; inhibition site 858619002727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619002728 catalytic residue [active] 858619002729 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 858619002730 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 858619002731 tetramerization interface [polypeptide binding]; other site 858619002732 NAD(P) binding site [chemical binding]; other site 858619002733 catalytic residues [active] 858619002734 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 858619002735 putative acyltransferase; Provisional; Region: PRK05790 858619002736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 858619002737 dimer interface [polypeptide binding]; other site 858619002738 active site 858619002739 Family description; Region: UvrD_C_2; pfam13538 858619002740 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 858619002741 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 858619002742 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 858619002743 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 858619002744 NAD(P) binding site [chemical binding]; other site 858619002745 catalytic residues [active] 858619002746 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 858619002747 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 858619002748 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 858619002749 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 858619002750 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 858619002751 PemK-like protein; Region: PemK; pfam02452 858619002752 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 858619002753 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 858619002754 GTP-binding protein LepA; Provisional; Region: PRK05433 858619002755 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 858619002756 G1 box; other site 858619002757 putative GEF interaction site [polypeptide binding]; other site 858619002758 GTP/Mg2+ binding site [chemical binding]; other site 858619002759 Switch I region; other site 858619002760 G2 box; other site 858619002761 G3 box; other site 858619002762 Switch II region; other site 858619002763 G4 box; other site 858619002764 G5 box; other site 858619002765 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 858619002766 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 858619002767 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 858619002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619002769 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619002770 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619002771 multiple promoter invertase; Provisional; Region: mpi; PRK13413 858619002772 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 858619002773 catalytic residues [active] 858619002774 catalytic nucleophile [active] 858619002775 Presynaptic Site I dimer interface [polypeptide binding]; other site 858619002776 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 858619002777 Synaptic Flat tetramer interface [polypeptide binding]; other site 858619002778 Synaptic Site I dimer interface [polypeptide binding]; other site 858619002779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619002780 DNA-binding interface [nucleotide binding]; DNA binding site 858619002781 Transposase [DNA replication, recombination, and repair]; Region: COG5421 858619002782 potential frameshift: common BLAST hit: gi|77454838|ref|YP_345706.1| putative transposase 858619002783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619002784 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619002785 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619002786 Resolvase, N terminal domain; Region: Resolvase; pfam00239 858619002787 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619002788 HTH domain; Region: HTH_22; pfam13309 858619002789 Transposase; Region: HTH_Tnp_1; pfam01527 858619002790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619002791 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 858619002792 active site 858619002793 metal binding site [ion binding]; metal-binding site 858619002794 Predicted acetyltransferase [General function prediction only]; Region: COG2388 858619002795 Protein of unknown function (DUF726); Region: DUF726; pfam05277 858619002796 putative oxidoreductase; Provisional; Region: PRK11579 858619002797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 858619002798 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 858619002799 Glycerate kinase family; Region: Gly_kinase; cl00841 858619002800 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 858619002801 active site 858619002802 oxyanion hole [active] 858619002803 catalytic triad [active] 858619002804 succinic semialdehyde dehydrogenase; Region: PLN02278 858619002805 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 858619002806 tetramerization interface [polypeptide binding]; other site 858619002807 NAD(P) binding site [chemical binding]; other site 858619002808 catalytic residues [active] 858619002809 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 858619002810 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 858619002811 NAD(P) binding site [chemical binding]; other site 858619002812 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 858619002813 GAF domain; Region: GAF; pfam01590 858619002814 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 858619002815 Pirin-related protein [General function prediction only]; Region: COG1741 858619002816 Pirin; Region: Pirin; pfam02678 858619002817 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 858619002818 Uncharacterized conserved protein [Function unknown]; Region: COG2128 858619002819 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 858619002820 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 858619002821 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 858619002822 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 858619002823 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 858619002824 tetrameric interface [polypeptide binding]; other site 858619002825 NAD binding site [chemical binding]; other site 858619002826 catalytic residues [active] 858619002827 hypothetical protein; Provisional; Region: PRK06062 858619002828 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619002829 inhibitor-cofactor binding pocket; inhibition site 858619002830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619002831 catalytic residue [active] 858619002832 Lipase maturation factor; Region: LMF1; pfam06762 858619002833 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 858619002834 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 858619002835 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 858619002836 putative metal binding site [ion binding]; other site 858619002837 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 858619002838 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 858619002839 active site residue [active] 858619002840 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 858619002841 active site residue [active] 858619002842 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 858619002843 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 858619002844 active site 858619002845 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 858619002846 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 858619002847 putative NAD(P) binding site [chemical binding]; other site 858619002848 catalytic Zn binding site [ion binding]; other site 858619002849 benzoate transporter; Region: benE; TIGR00843 858619002850 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 858619002851 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 858619002852 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 858619002853 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 858619002854 dimer interface [polypeptide binding]; other site 858619002855 FMN binding site [chemical binding]; other site 858619002856 NADPH bind site [chemical binding]; other site 858619002857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619002858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 858619002859 active site 858619002860 dimerization interface [polypeptide binding]; other site 858619002861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619002862 DNA binding residues [nucleotide binding] 858619002863 dimerization interface [polypeptide binding]; other site 858619002864 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 858619002865 conserved cys residue [active] 858619002866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619002867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619002868 non-specific DNA binding site [nucleotide binding]; other site 858619002869 salt bridge; other site 858619002870 sequence-specific DNA binding site [nucleotide binding]; other site 858619002871 Cupin domain; Region: Cupin_2; pfam07883 858619002872 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 858619002873 hydroxyglutarate oxidase; Provisional; Region: PRK11728 858619002874 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 858619002875 allantoate amidohydrolase; Reviewed; Region: PRK09290 858619002876 active site 858619002877 metal binding site [ion binding]; metal-binding site 858619002878 dimer interface [polypeptide binding]; other site 858619002879 ornithine cyclodeaminase; Validated; Region: PRK06199 858619002880 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 858619002881 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 858619002882 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 858619002883 FMN-binding pocket [chemical binding]; other site 858619002884 flavin binding motif; other site 858619002885 phosphate binding motif [ion binding]; other site 858619002886 beta-alpha-beta structure motif; other site 858619002887 NAD binding pocket [chemical binding]; other site 858619002888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 858619002889 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 858619002890 catalytic loop [active] 858619002891 iron binding site [ion binding]; other site 858619002892 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 858619002893 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 858619002894 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 858619002895 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 858619002896 FMN-binding pocket [chemical binding]; other site 858619002897 flavin binding motif; other site 858619002898 phosphate binding motif [ion binding]; other site 858619002899 beta-alpha-beta structure motif; other site 858619002900 NAD binding pocket [chemical binding]; other site 858619002901 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 858619002902 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 858619002903 catalytic loop [active] 858619002904 iron binding site [ion binding]; other site 858619002905 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 858619002906 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 858619002907 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 858619002908 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 858619002909 Citrate transporter; Region: CitMHS; pfam03600 858619002910 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 858619002911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619002912 ATP binding site [chemical binding]; other site 858619002913 Mg2+ binding site [ion binding]; other site 858619002914 G-X-G motif; other site 858619002915 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 858619002916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619002917 active site 858619002918 phosphorylation site [posttranslational modification] 858619002919 intermolecular recognition site; other site 858619002920 dimerization interface [polypeptide binding]; other site 858619002921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619002922 putative DNA binding site [nucleotide binding]; other site 858619002923 putative Zn2+ binding site [ion binding]; other site 858619002924 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619002925 active site 858619002926 A new structural DNA glycosylase; Region: AlkD_like; cl11434 858619002927 active site 858619002928 Amino acid permease; Region: AA_permease_2; pfam13520 858619002929 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 858619002930 hydroxyglutarate oxidase; Provisional; Region: PRK11728 858619002931 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 858619002932 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 858619002933 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 858619002934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619002935 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 858619002936 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 858619002937 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 858619002938 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 858619002939 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 858619002940 putative NAD(P) binding site [chemical binding]; other site 858619002941 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 858619002942 CoA-transferase family III; Region: CoA_transf_3; pfam02515 858619002943 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 858619002944 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 858619002945 putative ligand binding site [chemical binding]; other site 858619002946 putative NAD binding site [chemical binding]; other site 858619002947 catalytic site [active] 858619002948 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 858619002949 BCCT family transporter; Region: BCCT; pfam02028 858619002950 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 858619002951 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 858619002952 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 858619002953 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619002954 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 858619002955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619002956 Walker A/P-loop; other site 858619002957 ATP binding site [chemical binding]; other site 858619002958 Q-loop/lid; other site 858619002959 ABC transporter signature motif; other site 858619002960 Walker B; other site 858619002961 D-loop; other site 858619002962 H-loop/switch region; other site 858619002963 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 858619002964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619002966 homodimer interface [polypeptide binding]; other site 858619002967 catalytic residue [active] 858619002968 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619002969 active site 858619002970 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 858619002971 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 858619002972 substrate binding pocket [chemical binding]; other site 858619002973 catalytic triad [active] 858619002974 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 858619002975 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 858619002976 active site 858619002977 Zn binding site [ion binding]; other site 858619002978 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 858619002979 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 858619002980 acyl-activating enzyme (AAE) consensus motif; other site 858619002981 putative AMP binding site [chemical binding]; other site 858619002982 putative active site [active] 858619002983 putative CoA binding site [chemical binding]; other site 858619002984 coproporphyrinogen III oxidase; Validated; Region: PRK05628 858619002985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 858619002986 FeS/SAM binding site; other site 858619002987 HemN C-terminal domain; Region: HemN_C; pfam06969 858619002988 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 858619002989 HTH domain; Region: HTH_11; cl17392 858619002990 DnaJ domain; Region: DnaJ; pfam00226 858619002991 chaperone protein DnaJ; Provisional; Region: PRK14278 858619002992 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 858619002993 Zn binding sites [ion binding]; other site 858619002994 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 858619002995 dimer interface [polypeptide binding]; other site 858619002996 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 858619002997 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 858619002998 PhoH-like protein; Region: PhoH; pfam02562 858619002999 metal-binding heat shock protein; Provisional; Region: PRK00016 858619003000 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 858619003001 Domain of unknown function DUF21; Region: DUF21; pfam01595 858619003002 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 858619003003 Transporter associated domain; Region: CorC_HlyC; smart01091 858619003004 GTPase Era; Reviewed; Region: era; PRK00089 858619003005 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 858619003006 G1 box; other site 858619003007 GTP/Mg2+ binding site [chemical binding]; other site 858619003008 Switch I region; other site 858619003009 G2 box; other site 858619003010 Switch II region; other site 858619003011 G3 box; other site 858619003012 G4 box; other site 858619003013 G5 box; other site 858619003014 KH domain; Region: KH_2; pfam07650 858619003015 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 858619003016 Recombination protein O N terminal; Region: RecO_N; pfam11967 858619003017 Recombination protein O C terminal; Region: RecO_C; pfam02565 858619003018 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 858619003019 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 858619003020 catalytic residue [active] 858619003021 putative FPP diphosphate binding site; other site 858619003022 putative FPP binding hydrophobic cleft; other site 858619003023 dimer interface [polypeptide binding]; other site 858619003024 putative IPP diphosphate binding site; other site 858619003025 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 858619003026 diiron binding motif [ion binding]; other site 858619003027 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 858619003028 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 858619003029 metal binding site 2 [ion binding]; metal-binding site 858619003030 putative DNA binding helix; other site 858619003031 metal binding site 1 [ion binding]; metal-binding site 858619003032 dimer interface [polypeptide binding]; other site 858619003033 structural Zn2+ binding site [ion binding]; other site 858619003034 glycyl-tRNA synthetase; Provisional; Region: PRK04173 858619003035 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 858619003036 motif 1; other site 858619003037 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 858619003038 active site 858619003039 motif 2; other site 858619003040 motif 3; other site 858619003041 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 858619003042 anticodon binding site; other site 858619003043 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 858619003044 putative active site [active] 858619003045 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 858619003046 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 858619003047 Zn2+ binding site [ion binding]; other site 858619003048 Mg2+ binding site [ion binding]; other site 858619003049 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 858619003050 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 858619003051 active site 858619003052 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 858619003053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619003054 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 858619003055 DNA primase; Validated; Region: dnaG; PRK05667 858619003056 CHC2 zinc finger; Region: zf-CHC2; pfam01807 858619003057 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 858619003058 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 858619003059 active site 858619003060 metal binding site [ion binding]; metal-binding site 858619003061 interdomain interaction site; other site 858619003062 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 858619003063 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 858619003064 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 858619003065 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 858619003066 NAD binding site [chemical binding]; other site 858619003067 catalytic Zn binding site [ion binding]; other site 858619003068 substrate binding site [chemical binding]; other site 858619003069 structural Zn binding site [ion binding]; other site 858619003070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 858619003071 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 858619003072 putative homodimer interface [polypeptide binding]; other site 858619003073 putative homotetramer interface [polypeptide binding]; other site 858619003074 putative allosteric switch controlling residues; other site 858619003075 putative metal binding site [ion binding]; other site 858619003076 putative homodimer-homodimer interface [polypeptide binding]; other site 858619003077 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 858619003078 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 858619003079 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 858619003080 active site 858619003081 substrate binding site [chemical binding]; other site 858619003082 FMN binding site [chemical binding]; other site 858619003083 putative catalytic residues [active] 858619003084 Beta-lactamase; Region: Beta-lactamase; pfam00144 858619003085 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 858619003086 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 858619003087 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 858619003088 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 858619003089 dimer interface [polypeptide binding]; other site 858619003090 TPP-binding site [chemical binding]; other site 858619003091 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 858619003092 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 858619003093 Htaa; Region: HtaA; pfam04213 858619003094 Htaa; Region: HtaA; pfam04213 858619003095 Htaa; Region: HtaA; pfam04213 858619003096 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 858619003097 biotin synthase; Validated; Region: PRK06256 858619003098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 858619003099 FeS/SAM binding site; other site 858619003100 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 858619003101 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 858619003102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619003103 motif II; other site 858619003104 Low molecular weight phosphatase family; Region: LMWPc; cd00115 858619003105 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 858619003106 active site 858619003107 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 858619003108 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 858619003109 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619003110 catalytic core [active] 858619003111 Predicted membrane protein [Function unknown]; Region: COG2149 858619003112 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 858619003113 oligomerization interface [polypeptide binding]; other site 858619003114 active site 858619003115 metal binding site [ion binding]; metal-binding site 858619003116 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 858619003117 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 858619003118 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 858619003119 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 858619003120 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 858619003121 metal binding triad; other site 858619003122 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 858619003123 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 858619003124 metal binding triad; other site 858619003125 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 858619003126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619003127 dimer interface [polypeptide binding]; other site 858619003128 ABC-ATPase subunit interface; other site 858619003129 putative PBP binding regions; other site 858619003130 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 858619003131 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619003132 Walker A/P-loop; other site 858619003133 ATP binding site [chemical binding]; other site 858619003134 Q-loop/lid; other site 858619003135 ABC transporter signature motif; other site 858619003136 Walker B; other site 858619003137 D-loop; other site 858619003138 H-loop/switch region; other site 858619003139 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 858619003140 heme binding pocket [chemical binding]; other site 858619003141 heme ligand [chemical binding]; other site 858619003142 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 858619003143 nudix motif; other site 858619003144 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 858619003145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619003146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619003147 putative substrate translocation pore; other site 858619003148 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 858619003149 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 858619003150 ATP binding site [chemical binding]; other site 858619003151 substrate interface [chemical binding]; other site 858619003152 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 858619003153 active site residue [active] 858619003154 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 858619003155 ThiS interaction site; other site 858619003156 putative active site [active] 858619003157 tetramer interface [polypeptide binding]; other site 858619003158 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 858619003159 thiS-thiF/thiG interaction site; other site 858619003160 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 858619003161 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 858619003162 thiamine phosphate binding site [chemical binding]; other site 858619003163 active site 858619003164 pyrophosphate binding site [ion binding]; other site 858619003165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 858619003166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619003167 Coenzyme A binding pocket [chemical binding]; other site 858619003168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619003169 NADH(P)-binding; Region: NAD_binding_10; pfam13460 858619003170 NAD(P) binding site [chemical binding]; other site 858619003171 active site 858619003172 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 858619003173 NADH(P)-binding; Region: NAD_binding_10; pfam13460 858619003174 NAD(P) binding site [chemical binding]; other site 858619003175 putative active site [active] 858619003176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 858619003177 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 858619003178 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 858619003179 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619003180 active site 858619003181 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 858619003182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619003183 active site 858619003184 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 858619003185 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 858619003186 putative NAD(P) binding site [chemical binding]; other site 858619003187 putative substrate binding site [chemical binding]; other site 858619003188 catalytic Zn binding site [ion binding]; other site 858619003189 structural Zn binding site [ion binding]; other site 858619003190 dimer interface [polypeptide binding]; other site 858619003191 glutamine synthetase, type I; Region: GlnA; TIGR00653 858619003192 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 858619003193 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 858619003194 RDD family; Region: RDD; pfam06271 858619003195 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 858619003196 lipoyl synthase; Provisional; Region: PRK05481 858619003197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 858619003198 FeS/SAM binding site; other site 858619003199 lipoate-protein ligase B; Provisional; Region: PRK14345 858619003200 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 858619003201 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 858619003202 E3 interaction surface; other site 858619003203 lipoyl attachment site [posttranslational modification]; other site 858619003204 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 858619003205 E3 interaction surface; other site 858619003206 lipoyl attachment site [posttranslational modification]; other site 858619003207 e3 binding domain; Region: E3_binding; pfam02817 858619003208 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 858619003209 multifunctional aminopeptidase A; Provisional; Region: PRK00913 858619003210 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 858619003211 interface (dimer of trimers) [polypeptide binding]; other site 858619003212 Substrate-binding/catalytic site; other site 858619003213 Zn-binding sites [ion binding]; other site 858619003214 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 858619003215 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 858619003216 homodimer interface [polypeptide binding]; other site 858619003217 substrate-cofactor binding pocket; other site 858619003218 catalytic residue [active] 858619003219 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 858619003220 active site pocket [active] 858619003221 putative cataytic base [active] 858619003222 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 858619003223 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 858619003224 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 858619003225 active site 858619003226 dimer interface [polypeptide binding]; other site 858619003227 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 858619003228 Ligand Binding Site [chemical binding]; other site 858619003229 Molecular Tunnel; other site 858619003230 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 858619003231 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 858619003232 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 858619003233 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 858619003234 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 858619003235 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 858619003236 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 858619003237 Subunit I/III interface [polypeptide binding]; other site 858619003238 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 858619003239 Cytochrome c; Region: Cytochrom_C; pfam00034 858619003240 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 858619003241 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 858619003242 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 858619003243 iron-sulfur cluster [ion binding]; other site 858619003244 [2Fe-2S] cluster binding site [ion binding]; other site 858619003245 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 858619003246 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 858619003247 heme bH binding site [chemical binding]; other site 858619003248 intrachain domain interface; other site 858619003249 heme bL binding site [chemical binding]; other site 858619003250 interchain domain interface [polypeptide binding]; other site 858619003251 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 858619003252 Qo binding site; other site 858619003253 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 858619003254 active site 858619003255 catalytic site [active] 858619003256 substrate binding site [chemical binding]; other site 858619003257 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 858619003258 NlpC/P60 family; Region: NLPC_P60; pfam00877 858619003259 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 858619003260 NlpC/P60 family; Region: NLPC_P60; pfam00877 858619003261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 858619003262 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 858619003263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 858619003264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 858619003265 nucleotide binding site [chemical binding]; other site 858619003266 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 858619003267 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 858619003268 putative acyl-acceptor binding pocket; other site 858619003269 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 858619003270 Predicted membrane protein [Function unknown]; Region: COG4763 858619003271 Acyltransferase family; Region: Acyl_transf_3; pfam01757 858619003272 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 858619003273 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 858619003274 Catalytic domain of Protein Kinases; Region: PKc; cd00180 858619003275 active site 858619003276 ATP binding site [chemical binding]; other site 858619003277 substrate binding site [chemical binding]; other site 858619003278 activation loop (A-loop); other site 858619003279 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619003280 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619003281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 858619003282 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 858619003283 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 858619003284 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 858619003285 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 858619003286 substrate binding pocket [chemical binding]; other site 858619003287 chain length determination region; other site 858619003288 substrate-Mg2+ binding site; other site 858619003289 catalytic residues [active] 858619003290 aspartate-rich region 1; other site 858619003291 active site lid residues [active] 858619003292 aspartate-rich region 2; other site 858619003293 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 858619003294 FAD binding site [chemical binding]; other site 858619003295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 858619003296 Coenzyme A binding pocket [chemical binding]; other site 858619003297 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 858619003298 cell division protein MraZ; Reviewed; Region: PRK00326 858619003299 MraZ protein; Region: MraZ; pfam02381 858619003300 MraZ protein; Region: MraZ; pfam02381 858619003301 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 858619003302 MraW methylase family; Region: Methyltransf_5; cl17771 858619003303 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 858619003304 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 858619003305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 858619003306 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 858619003307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 858619003308 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 858619003309 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 858619003310 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 858619003311 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 858619003312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 858619003313 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 858619003314 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 858619003315 Mg++ binding site [ion binding]; other site 858619003316 putative catalytic motif [active] 858619003317 putative substrate binding site [chemical binding]; other site 858619003318 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 858619003319 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 858619003320 cell division protein FtsW; Region: ftsW; TIGR02614 858619003321 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 858619003322 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 858619003323 active site 858619003324 homodimer interface [polypeptide binding]; other site 858619003325 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 858619003326 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 858619003327 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 858619003328 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 858619003329 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 858619003330 Cell division protein FtsQ; Region: FtsQ; pfam03799 858619003331 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 858619003332 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 858619003333 nucleotide binding site [chemical binding]; other site 858619003334 SulA interaction site; other site 858619003335 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 858619003336 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 858619003337 Protein of unknown function (DUF552); Region: DUF552; pfam04472 858619003338 YGGT family; Region: YGGT; cl00508 858619003339 DivIVA domain; Region: DivI1A_domain; TIGR03544 858619003340 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 858619003341 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 858619003342 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 858619003343 HIGH motif; other site 858619003344 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 858619003345 active site 858619003346 KMSKS motif; other site 858619003347 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 858619003348 tRNA binding surface [nucleotide binding]; other site 858619003349 anticodon binding site; other site 858619003350 phenylalanine transporter; Provisional; Region: PRK10249 858619003351 DNA polymerase IV; Provisional; Region: PRK03348 858619003352 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 858619003353 active site 858619003354 DNA binding site [nucleotide binding] 858619003355 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 858619003356 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 858619003357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 858619003358 active site 858619003359 Predicted permeases [General function prediction only]; Region: RarD; COG2962 858619003360 EamA-like transporter family; Region: EamA; pfam00892 858619003361 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 858619003362 FAD binding domain; Region: FAD_binding_4; pfam01565 858619003363 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 858619003364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 858619003365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 858619003366 catalytic residue [active] 858619003367 quinolinate synthetase; Provisional; Region: PRK09375 858619003368 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 858619003369 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 858619003370 dimerization interface [polypeptide binding]; other site 858619003371 active site 858619003372 SnoaL-like domain; Region: SnoaL_4; cl17707 858619003373 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 858619003374 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 858619003375 active site 858619003376 PHP Thumb interface [polypeptide binding]; other site 858619003377 metal binding site [ion binding]; metal-binding site 858619003378 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 858619003379 generic binding surface II; other site 858619003380 generic binding surface I; other site 858619003381 Uncharacterized conserved protein [Function unknown]; Region: COG1739 858619003382 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 858619003383 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 858619003384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 858619003385 RNA binding surface [nucleotide binding]; other site 858619003386 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 858619003387 synthetase active site [active] 858619003388 NTP binding site [chemical binding]; other site 858619003389 metal binding site [ion binding]; metal-binding site 858619003390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619003391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619003392 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 858619003393 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 858619003394 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 858619003395 NAD binding site [chemical binding]; other site 858619003396 dimerization interface [polypeptide binding]; other site 858619003397 product binding site; other site 858619003398 substrate binding site [chemical binding]; other site 858619003399 zinc binding site [ion binding]; other site 858619003400 catalytic residues [active] 858619003401 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 858619003402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619003403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619003404 homodimer interface [polypeptide binding]; other site 858619003405 catalytic residue [active] 858619003406 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 858619003407 putative active site pocket [active] 858619003408 4-fold oligomerization interface [polypeptide binding]; other site 858619003409 metal binding residues [ion binding]; metal-binding site 858619003410 3-fold/trimer interface [polypeptide binding]; other site 858619003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619003412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619003413 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 858619003414 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 858619003415 putative active site [active] 858619003416 oxyanion strand; other site 858619003417 catalytic triad [active] 858619003418 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 858619003419 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 858619003420 catalytic residues [active] 858619003421 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 858619003422 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 858619003423 active site 858619003424 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 858619003425 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 858619003426 substrate binding site [chemical binding]; other site 858619003427 glutamase interaction surface [polypeptide binding]; other site 858619003428 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 858619003429 anthranilate synthase component I; Provisional; Region: PRK13571 858619003430 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 858619003431 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 858619003432 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 858619003433 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 858619003434 active site 858619003435 ribulose/triose binding site [chemical binding]; other site 858619003436 phosphate binding site [ion binding]; other site 858619003437 substrate (anthranilate) binding pocket [chemical binding]; other site 858619003438 product (indole) binding pocket [chemical binding]; other site 858619003439 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 858619003440 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 858619003441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619003442 catalytic residue [active] 858619003443 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 858619003444 substrate binding site [chemical binding]; other site 858619003445 active site 858619003446 catalytic residues [active] 858619003447 heterodimer interface [polypeptide binding]; other site 858619003448 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 858619003449 pyruvate kinase; Provisional; Region: PRK06247 858619003450 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 858619003451 domain interfaces; other site 858619003452 active site 858619003453 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 858619003454 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 858619003455 active site 858619003456 nucleophile elbow; other site 858619003457 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 858619003458 amidohydrolase; Region: amidohydrolases; TIGR01891 858619003459 metal binding site [ion binding]; metal-binding site 858619003460 putative dimer interface [polypeptide binding]; other site 858619003461 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 858619003462 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 858619003463 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 858619003464 Walker A/P-loop; other site 858619003465 ATP binding site [chemical binding]; other site 858619003466 Q-loop/lid; other site 858619003467 ABC transporter signature motif; other site 858619003468 Walker B; other site 858619003469 D-loop; other site 858619003470 H-loop/switch region; other site 858619003471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619003472 dimer interface [polypeptide binding]; other site 858619003473 conserved gate region; other site 858619003474 putative PBP binding loops; other site 858619003475 ABC-ATPase subunit interface; other site 858619003476 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 858619003477 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 858619003478 substrate binding pocket [chemical binding]; other site 858619003479 membrane-bound complex binding site; other site 858619003480 hinge residues; other site 858619003481 glutaminase; Provisional; Region: PRK00971 858619003482 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 858619003483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619003484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619003485 DNA polymerase I; Provisional; Region: PRK05755 858619003486 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 858619003487 active site 858619003488 metal binding site 3; metal-binding site 858619003489 metal binding site 1 [ion binding]; metal-binding site 858619003490 metal binding site 2 [ion binding]; metal-binding site 858619003491 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 858619003492 putative DNA binding site [nucleotide binding]; other site 858619003493 putative metal binding site [ion binding]; other site 858619003494 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 858619003495 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 858619003496 active site 858619003497 DNA binding site [nucleotide binding] 858619003498 catalytic site [active] 858619003499 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 858619003500 MgtC family; Region: MgtC; pfam02308 858619003501 Domain of unknown function (DUF368); Region: DUF368; pfam04018 858619003502 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 858619003503 tartrate dehydrogenase; Region: TTC; TIGR02089 858619003504 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 858619003505 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 858619003506 RNA binding site [nucleotide binding]; other site 858619003507 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 858619003508 RNA binding site [nucleotide binding]; other site 858619003509 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 858619003510 RNA binding site [nucleotide binding]; other site 858619003511 S1 RNA binding domain; Region: S1; pfam00575 858619003512 RNA binding site [nucleotide binding]; other site 858619003513 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 858619003514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619003515 NAD(P) binding site [chemical binding]; other site 858619003516 active site 858619003517 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 858619003518 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 858619003519 active site turn [active] 858619003520 phosphorylation site [posttranslational modification] 858619003521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 858619003522 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 858619003523 HPr interaction site; other site 858619003524 glycerol kinase (GK) interaction site [polypeptide binding]; other site 858619003525 active site 858619003526 phosphorylation site [posttranslational modification] 858619003527 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 858619003528 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 858619003529 active site 2 [active] 858619003530 active site 1 [active] 858619003531 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 858619003532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619003533 NAD(P) binding site [chemical binding]; other site 858619003534 active site 858619003535 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 858619003536 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 858619003537 dimer interface [polypeptide binding]; other site 858619003538 active site 858619003539 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 858619003540 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 858619003541 CoA-binding site [chemical binding]; other site 858619003542 ATP-binding [chemical binding]; other site 858619003543 excinuclease ABC subunit B; Provisional; Region: PRK05298 858619003544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619003545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619003546 nucleotide binding region [chemical binding]; other site 858619003547 ATP-binding site [chemical binding]; other site 858619003548 Ultra-violet resistance protein B; Region: UvrB; pfam12344 858619003549 UvrB/uvrC motif; Region: UVR; pfam02151 858619003550 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619003551 Ligand Binding Site [chemical binding]; other site 858619003552 TAP-like protein; Region: Abhydrolase_4; pfam08386 858619003553 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 858619003554 Family description; Region: UvrD_C_2; pfam13538 858619003555 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 858619003556 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 858619003557 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 858619003558 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 858619003559 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 858619003560 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 858619003561 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 858619003562 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 858619003563 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 858619003564 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 858619003565 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 858619003566 23S rRNA binding site [nucleotide binding]; other site 858619003567 L21 binding site [polypeptide binding]; other site 858619003568 L13 binding site [polypeptide binding]; other site 858619003569 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 858619003570 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 858619003571 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 858619003572 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 858619003573 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 858619003574 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 858619003575 dimer interface [polypeptide binding]; other site 858619003576 motif 1; other site 858619003577 active site 858619003578 motif 2; other site 858619003579 motif 3; other site 858619003580 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 858619003581 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 858619003582 putative tRNA-binding site [nucleotide binding]; other site 858619003583 B3/4 domain; Region: B3_4; pfam03483 858619003584 tRNA synthetase B5 domain; Region: B5; smart00874 858619003585 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 858619003586 dimer interface [polypeptide binding]; other site 858619003587 motif 1; other site 858619003588 motif 3; other site 858619003589 motif 2; other site 858619003590 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 858619003591 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 858619003592 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 858619003593 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 858619003594 heterotetramer interface [polypeptide binding]; other site 858619003595 active site pocket [active] 858619003596 cleavage site 858619003597 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 858619003598 feedback inhibition sensing region; other site 858619003599 homohexameric interface [polypeptide binding]; other site 858619003600 nucleotide binding site [chemical binding]; other site 858619003601 N-acetyl-L-glutamate binding site [chemical binding]; other site 858619003602 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 858619003603 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619003604 inhibitor-cofactor binding pocket; inhibition site 858619003605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619003606 catalytic residue [active] 858619003607 ornithine carbamoyltransferase; Provisional; Region: PRK00779 858619003608 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 858619003609 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 858619003610 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 858619003611 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 858619003612 argininosuccinate synthase; Provisional; Region: PRK13820 858619003613 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 858619003614 ANP binding site [chemical binding]; other site 858619003615 Substrate Binding Site II [chemical binding]; other site 858619003616 Substrate Binding Site I [chemical binding]; other site 858619003617 argininosuccinate lyase; Provisional; Region: PRK00855 858619003618 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 858619003619 active sites [active] 858619003620 tetramer interface [polypeptide binding]; other site 858619003621 Uncharacterized conserved protein [Function unknown]; Region: COG2835 858619003622 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 858619003623 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 858619003624 active site 858619003625 HIGH motif; other site 858619003626 dimer interface [polypeptide binding]; other site 858619003627 KMSKS motif; other site 858619003628 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 858619003629 active site 858619003630 catalytic residues [active] 858619003631 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 858619003632 putative transporter; Provisional; Region: PRK10484 858619003633 Na binding site [ion binding]; other site 858619003634 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 858619003635 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 858619003636 nucleotide binding site/active site [active] 858619003637 HIT family signature motif; other site 858619003638 catalytic residue [active] 858619003639 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 858619003640 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 858619003641 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 858619003642 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 858619003643 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 858619003644 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 858619003645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619003646 hemolysin TlyA family protein; Region: tly; TIGR00478 858619003647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619003648 S-adenosylmethionine binding site [chemical binding]; other site 858619003649 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 858619003650 ATP-NAD kinase; Region: NAD_kinase; pfam01513 858619003651 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 858619003652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619003653 Walker A/P-loop; other site 858619003654 ATP binding site [chemical binding]; other site 858619003655 Q-loop/lid; other site 858619003656 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 858619003657 ABC transporter signature motif; other site 858619003658 Walker B; other site 858619003659 D-loop; other site 858619003660 H-loop/switch region; other site 858619003661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619003662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619003663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 858619003664 dimerization interface [polypeptide binding]; other site 858619003665 HPP family; Region: HPP; pfam04982 858619003666 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 858619003667 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 858619003668 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 858619003669 CTP synthetase; Validated; Region: pyrG; PRK05380 858619003670 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 858619003671 Catalytic site [active] 858619003672 active site 858619003673 UTP binding site [chemical binding]; other site 858619003674 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 858619003675 active site 858619003676 putative oxyanion hole; other site 858619003677 catalytic triad [active] 858619003678 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 858619003679 dimer interface [polypeptide binding]; other site 858619003680 active site 858619003681 ADP-ribose binding site [chemical binding]; other site 858619003682 nudix motif; other site 858619003683 metal binding site [ion binding]; metal-binding site 858619003684 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 858619003685 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 858619003686 active site 858619003687 DNA binding site [nucleotide binding] 858619003688 Int/Topo IB signature motif; other site 858619003689 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 858619003690 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 858619003691 P-loop; other site 858619003692 Magnesium ion binding site [ion binding]; other site 858619003693 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 858619003694 Magnesium ion binding site [ion binding]; other site 858619003695 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 858619003696 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 858619003697 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 858619003698 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 858619003699 RNA binding surface [nucleotide binding]; other site 858619003700 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 858619003701 active site 858619003702 potential frameshift: common BLAST hit: gi|68535955|ref|YP_250660.1| bifunctional cytidylate kinase/GTP-binding protein 858619003703 cytidylate kinase; Provisional; Region: cmk; PRK00023 858619003704 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 858619003705 CMP-binding site; other site 858619003706 The sites determining sugar specificity; other site 858619003707 GTP-binding protein Der; Reviewed; Region: PRK03003 858619003708 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 858619003709 G1 box; other site 858619003710 GTP/Mg2+ binding site [chemical binding]; other site 858619003711 Switch I region; other site 858619003712 G2 box; other site 858619003713 Switch II region; other site 858619003714 G3 box; other site 858619003715 G4 box; other site 858619003716 G5 box; other site 858619003717 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 858619003718 G1 box; other site 858619003719 GTP/Mg2+ binding site [chemical binding]; other site 858619003720 Switch I region; other site 858619003721 G2 box; other site 858619003722 G3 box; other site 858619003723 Switch II region; other site 858619003724 G4 box; other site 858619003725 G5 box; other site 858619003726 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 858619003727 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 858619003728 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 858619003729 putative proline-specific permease; Provisional; Region: proY; PRK10580 858619003730 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619003731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003732 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003733 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619003734 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 858619003735 inhibitor-cofactor binding pocket; inhibition site 858619003736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619003737 catalytic residue [active] 858619003738 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 858619003739 AAA domain; Region: AAA_26; pfam13500 858619003740 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619003741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619003742 Q-loop/lid; other site 858619003743 ABC transporter signature motif; other site 858619003744 Walker B; other site 858619003745 D-loop; other site 858619003746 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619003747 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619003748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619003749 Q-loop/lid; other site 858619003750 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 858619003751 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 858619003752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 858619003753 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 858619003754 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 858619003755 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 858619003756 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 858619003757 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 858619003758 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 858619003759 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 858619003760 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 858619003761 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 858619003762 phosphopeptide binding site; other site 858619003763 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 858619003764 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 858619003765 DNA binding residues [nucleotide binding] 858619003766 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 858619003767 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 858619003768 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 858619003769 DNA binding residues [nucleotide binding] 858619003770 Domain of unknown function DUF21; Region: DUF21; pfam01595 858619003771 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 858619003772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 858619003773 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 858619003774 Domain of unknown function DUF21; Region: DUF21; pfam01595 858619003775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 858619003776 Transporter associated domain; Region: CorC_HlyC; pfam03471 858619003777 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 858619003778 DEAD-like helicases superfamily; Region: DEXDc; smart00487 858619003779 ATP binding site [chemical binding]; other site 858619003780 Mg++ binding site [ion binding]; other site 858619003781 motif III; other site 858619003782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619003783 nucleotide binding region [chemical binding]; other site 858619003784 ATP-binding site [chemical binding]; other site 858619003785 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 858619003786 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 858619003787 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 858619003788 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 858619003789 CoenzymeA binding site [chemical binding]; other site 858619003790 subunit interaction site [polypeptide binding]; other site 858619003791 PHB binding site; other site 858619003792 potential frameshift: common BLAST hit: gi|25028147|ref|NP_738201.1| multifunctional thiamine-phosphate 858619003793 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 858619003794 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 858619003795 dimer interface [polypeptide binding]; other site 858619003796 substrate binding site [chemical binding]; other site 858619003797 ATP binding site [chemical binding]; other site 858619003798 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 858619003799 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 858619003800 active site 858619003801 thiamine phosphate binding site [chemical binding]; other site 858619003802 pyrophosphate binding site [ion binding]; other site 858619003803 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 858619003804 substrate binding site [chemical binding]; other site 858619003805 multimerization interface [polypeptide binding]; other site 858619003806 ATP binding site [chemical binding]; other site 858619003807 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 858619003808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619003809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619003810 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 858619003811 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 858619003812 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 858619003813 metabolite-proton symporter; Region: 2A0106; TIGR00883 858619003814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619003815 putative substrate translocation pore; other site 858619003816 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 858619003817 FAD binding domain; Region: FAD_binding_2; pfam00890 858619003818 amidase; Provisional; Region: PRK12470 858619003819 Amidase; Region: Amidase; cl11426 858619003820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619003821 active site 858619003822 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 858619003823 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 858619003824 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 858619003825 BCCT family transporter; Region: BCCT; pfam02028 858619003826 HSP90 family protein; Provisional; Region: PRK14083 858619003827 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 858619003828 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 858619003829 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 858619003830 substrate binding site [chemical binding]; other site 858619003831 dimer interface [polypeptide binding]; other site 858619003832 ATP binding site [chemical binding]; other site 858619003833 META domain; Region: META; cl01245 858619003834 aminotransferase AlaT; Validated; Region: PRK09265 858619003835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619003836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619003837 homodimer interface [polypeptide binding]; other site 858619003838 catalytic residue [active] 858619003839 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 858619003840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619003841 META domain; Region: META; pfam03724 858619003842 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 858619003843 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 858619003844 hypothetical protein; Validated; Region: PRK07581 858619003845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619003846 S-adenosylmethionine binding site [chemical binding]; other site 858619003847 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 858619003848 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 858619003849 active site 2 [active] 858619003850 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 858619003851 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 858619003852 active site 858619003853 AAA ATPase domain; Region: AAA_16; pfam13191 858619003854 AAA domain; Region: AAA_22; pfam13401 858619003855 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 858619003856 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 858619003857 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 858619003858 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 858619003859 nucleotide binding site [chemical binding]; other site 858619003860 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 858619003861 Domain of unknown function DUF77; Region: DUF77; pfam01910 858619003862 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 858619003863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619003864 catalytic residue [active] 858619003865 Protein of unknown function (DUF952); Region: DUF952; pfam06108 858619003866 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 858619003867 active site 858619003868 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 858619003869 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 858619003870 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 858619003871 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 858619003872 LGFP repeat; Region: LGFP; pfam08310 858619003873 LGFP repeat; Region: LGFP; pfam08310 858619003874 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 858619003875 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619003876 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 858619003877 Presynaptic Site I dimer interface [polypeptide binding]; other site 858619003878 catalytic residues [active] 858619003879 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 858619003880 Synaptic Flat tetramer interface [polypeptide binding]; other site 858619003881 Synaptic Site I dimer interface [polypeptide binding]; other site 858619003882 DNA binding site [nucleotide binding] 858619003883 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619003884 DNA-binding interface [nucleotide binding]; DNA binding site 858619003885 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 858619003886 transposase; Provisional; Region: PRK06526 858619003887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619003888 ATP binding site [chemical binding]; other site 858619003889 Walker A motif; other site 858619003890 Walker B motif; other site 858619003891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 858619003892 Integrase core domain; Region: rve; pfam00665 858619003893 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619003894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003895 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003896 Transposase; Region: DEDD_Tnp_IS110; pfam01548 858619003897 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619003898 MULE transposase domain; Region: MULE; pfam10551 858619003899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003900 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 858619003902 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 858619003903 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 858619003904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619003905 Walker A/P-loop; other site 858619003906 ATP binding site [chemical binding]; other site 858619003907 Q-loop/lid; other site 858619003908 ABC transporter signature motif; other site 858619003909 Walker B; other site 858619003910 D-loop; other site 858619003911 H-loop/switch region; other site 858619003912 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619003913 MULE transposase domain; Region: MULE; pfam10551 858619003914 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003917 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619003918 DNA-binding interface [nucleotide binding]; DNA binding site 858619003919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619003920 putative transposase OrfB; Reviewed; Region: PHA02517 858619003921 HTH-like domain; Region: HTH_21; pfam13276 858619003922 Integrase core domain; Region: rve; pfam00665 858619003923 Integrase core domain; Region: rve_3; pfam13683 858619003924 adaptive-response sensory kinase; Validated; Region: PRK09303 858619003925 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619003926 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619003927 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619003928 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003930 transposase; Provisional; Region: PRK06526 858619003931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619003932 ATP binding site [chemical binding]; other site 858619003933 Walker A motif; other site 858619003934 Walker B motif; other site 858619003935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 858619003936 Integrase core domain; Region: rve; pfam00665 858619003937 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619003938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003939 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003940 Replicase family; Region: Replicase; pfam03090 858619003941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003942 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003943 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619003944 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 858619003945 catalytic residues [active] 858619003946 catalytic nucleophile [active] 858619003947 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 858619003948 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619003949 DNA-binding interface [nucleotide binding]; DNA binding site 858619003950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619003951 transposase; Provisional; Region: PRK06526 858619003952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619003953 ATP binding site [chemical binding]; other site 858619003954 Walker A motif; other site 858619003955 Walker B motif; other site 858619003956 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619003957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 858619003958 DNA-binding interface [nucleotide binding]; DNA binding site 858619003959 Integrase core domain; Region: rve; pfam00665 858619003960 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619003961 D-lactate dehydrogenase; Provisional; Region: PRK11183 858619003962 FAD binding domain; Region: FAD_binding_4; pfam01565 858619003963 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 858619003964 putative transposase OrfB; Reviewed; Region: PHA02517 858619003965 HTH-like domain; Region: HTH_21; pfam13276 858619003966 Integrase core domain; Region: rve; pfam00665 858619003967 Integrase core domain; Region: rve_3; pfam13683 858619003968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619003969 Transposase; Region: HTH_Tnp_1; pfam01527 858619003970 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003972 D-lactate dehydrogenase; Provisional; Region: PRK11183 858619003973 FAD binding domain; Region: FAD_binding_4; pfam01565 858619003974 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 858619003975 Helix-turn-helix domain; Region: HTH_28; pfam13518 858619003976 Winged helix-turn helix; Region: HTH_29; pfam13551 858619003977 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619003978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619003979 transposase; Provisional; Region: PRK06526 858619003980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619003981 ATP binding site [chemical binding]; other site 858619003982 Walker A motif; other site 858619003983 Walker B motif; other site 858619003984 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619003985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 858619003986 DNA-binding interface [nucleotide binding]; DNA binding site 858619003987 Integrase core domain; Region: rve; pfam00665 858619003988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 858619003989 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 858619003990 active site 858619003991 metal binding site [ion binding]; metal-binding site 858619003992 Bacterial TniB protein; Region: TniB; pfam05621 858619003993 AAA domain; Region: AAA_22; pfam13401 858619003994 Winged helix-turn helix; Region: HTH_29; pfam13551 858619003995 Homeodomain-like domain; Region: HTH_32; pfam13565 858619003996 Integrase core domain; Region: rve; pfam00665 858619003997 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 858619003998 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 858619003999 RibD C-terminal domain; Region: RibD_C; cl17279 858619004000 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 858619004001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619004002 ABC transporter signature motif; other site 858619004003 Walker B; other site 858619004004 D-loop; other site 858619004005 H-loop/switch region; other site 858619004006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619004007 ABC transporter signature motif; other site 858619004008 Walker B; other site 858619004009 D-loop; other site 858619004010 H-loop/switch region; other site 858619004011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619004012 Walker A/P-loop; other site 858619004013 ATP binding site [chemical binding]; other site 858619004014 Q-loop/lid; other site 858619004015 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 858619004016 MgtE intracellular N domain; Region: MgtE_N; smart00924 858619004017 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 858619004018 Divalent cation transporter; Region: MgtE; pfam01769 858619004019 YceI-like domain; Region: YceI; pfam04264 858619004020 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 858619004021 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 858619004022 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 858619004023 Ligand binding site; other site 858619004024 Putative Catalytic site; other site 858619004025 DXD motif; other site 858619004026 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 858619004027 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 858619004028 putative active site [active] 858619004029 catalytic triad [active] 858619004030 putative dimer interface [polypeptide binding]; other site 858619004031 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 858619004032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619004033 NAD(P) binding site [chemical binding]; other site 858619004034 active site 858619004035 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 858619004036 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 858619004037 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 858619004038 active site 858619004039 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 858619004040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619004041 ATP binding site [chemical binding]; other site 858619004042 putative Mg++ binding site [ion binding]; other site 858619004043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619004044 nucleotide binding region [chemical binding]; other site 858619004045 ATP-binding site [chemical binding]; other site 858619004046 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 858619004047 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 858619004048 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 858619004049 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 858619004050 Pup-ligase protein; Region: Pup_ligase; cl15463 858619004051 Pup-like protein; Region: Pup; cl05289 858619004052 Pup-ligase protein; Region: Pup_ligase; cl15463 858619004053 proteasome ATPase; Region: pup_AAA; TIGR03689 858619004054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619004055 Walker A motif; other site 858619004056 ATP binding site [chemical binding]; other site 858619004057 Walker B motif; other site 858619004058 arginine finger; other site 858619004059 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 858619004060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619004061 S-adenosylmethionine binding site [chemical binding]; other site 858619004062 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 858619004063 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 858619004064 catalytic residues [active] 858619004065 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 858619004066 FAD binding domain; Region: FAD_binding_4; pfam01565 858619004067 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 858619004068 FAD binding domain; Region: FAD_binding_4; pfam01565 858619004069 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 858619004070 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 858619004071 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 858619004072 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 858619004073 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 858619004074 NAD-dependent deacetylase; Provisional; Region: PRK05333 858619004075 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 858619004076 Aspartase; Region: Aspartase; cd01357 858619004077 active sites [active] 858619004078 tetramer interface [polypeptide binding]; other site 858619004079 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 858619004080 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 858619004081 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 858619004082 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 858619004083 homodimer interface [polypeptide binding]; other site 858619004084 putative metal binding site [ion binding]; other site 858619004085 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 858619004086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619004087 active site 858619004088 motif I; other site 858619004089 motif II; other site 858619004090 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 858619004091 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 858619004092 CoenzymeA binding site [chemical binding]; other site 858619004093 subunit interaction site [polypeptide binding]; other site 858619004094 PHB binding site; other site 858619004095 Winged helix-turn helix; Region: HTH_29; pfam13551 858619004096 Homeodomain-like domain; Region: HTH_23; cl17451 858619004097 Integrase core domain; Region: rve; pfam00665 858619004098 Integrase core domain; Region: rve_3; pfam13683 858619004099 Integrase core domain; Region: rve; pfam00665 858619004100 Integrase core domain; Region: rve_3; cl15866 858619004101 Winged helix-turn helix; Region: HTH_29; pfam13551 858619004102 Homeodomain-like domain; Region: HTH_23; cl17451 858619004103 Integrase core domain; Region: rve; pfam00665 858619004104 Integrase core domain; Region: rve_3; pfam13683 858619004105 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 858619004106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619004107 active site 858619004108 HIGH motif; other site 858619004109 nucleotide binding site [chemical binding]; other site 858619004110 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619004111 active site 858619004112 KMSKS motif; other site 858619004113 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 858619004114 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 858619004115 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 858619004116 quinone interaction residues [chemical binding]; other site 858619004117 active site 858619004118 catalytic residues [active] 858619004119 FMN binding site [chemical binding]; other site 858619004120 substrate binding site [chemical binding]; other site 858619004121 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 858619004122 substrate binding site [chemical binding]; other site 858619004123 Uncharacterized conserved protein [Function unknown]; Region: COG0398 858619004124 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 858619004125 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 858619004126 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 858619004127 NlpC/P60 family; Region: NLPC_P60; pfam00877 858619004128 aconitate hydratase; Validated; Region: PRK09277 858619004129 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 858619004130 substrate binding site [chemical binding]; other site 858619004131 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 858619004132 ligand binding site [chemical binding]; other site 858619004133 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 858619004134 substrate binding site [chemical binding]; other site 858619004135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619004136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619004137 hypothetical protein; Validated; Region: PRK00194 858619004138 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 858619004139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 858619004140 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 858619004141 phosphate binding site [ion binding]; other site 858619004142 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 858619004143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619004144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619004145 Walker A/P-loop; other site 858619004146 ATP binding site [chemical binding]; other site 858619004147 Q-loop/lid; other site 858619004148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619004149 ABC transporter signature motif; other site 858619004150 Walker B; other site 858619004151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619004152 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 858619004153 lycopene cyclase; Region: lycopene_cycl; TIGR01789 858619004154 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 858619004155 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 858619004156 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 858619004157 trimerization site [polypeptide binding]; other site 858619004158 active site 858619004159 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 858619004160 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 858619004161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619004162 catalytic residue [active] 858619004163 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 858619004164 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 858619004165 Walker A/P-loop; other site 858619004166 ATP binding site [chemical binding]; other site 858619004167 Q-loop/lid; other site 858619004168 ABC transporter signature motif; other site 858619004169 Walker B; other site 858619004170 D-loop; other site 858619004171 H-loop/switch region; other site 858619004172 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 858619004173 FeS assembly protein SufD; Region: sufD; TIGR01981 858619004174 FeS assembly protein SufB; Region: sufB; TIGR01980 858619004175 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 858619004176 Predicted transcriptional regulator [Transcription]; Region: COG2345 858619004177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619004178 putative DNA binding site [nucleotide binding]; other site 858619004179 putative Zn2+ binding site [ion binding]; other site 858619004180 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 858619004181 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 858619004182 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 858619004183 Walker A/P-loop; other site 858619004184 ATP binding site [chemical binding]; other site 858619004185 Q-loop/lid; other site 858619004186 ABC transporter signature motif; other site 858619004187 Walker B; other site 858619004188 D-loop; other site 858619004189 H-loop/switch region; other site 858619004190 ABC-2 type transporter; Region: ABC2_membrane; cl17235 858619004191 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 858619004192 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 858619004193 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 858619004194 UbiA prenyltransferase family; Region: UbiA; pfam01040 858619004195 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 858619004196 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 858619004197 TPP-binding site [chemical binding]; other site 858619004198 dimer interface [polypeptide binding]; other site 858619004199 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 858619004200 PYR/PP interface [polypeptide binding]; other site 858619004201 dimer interface [polypeptide binding]; other site 858619004202 TPP binding site [chemical binding]; other site 858619004203 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 858619004204 putative active site [active] 858619004205 transaldolase; Provisional; Region: PRK03903 858619004206 catalytic residue [active] 858619004207 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 858619004208 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 858619004209 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 858619004210 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 858619004211 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 858619004212 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 858619004213 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 858619004214 putative active site [active] 858619004215 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 858619004216 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 858619004217 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 858619004218 triosephosphate isomerase; Provisional; Region: PRK14565 858619004219 substrate binding site [chemical binding]; other site 858619004220 dimer interface [polypeptide binding]; other site 858619004221 catalytic triad [active] 858619004222 Phosphoglycerate kinase; Region: PGK; pfam00162 858619004223 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 858619004224 substrate binding site [chemical binding]; other site 858619004225 hinge regions; other site 858619004226 ADP binding site [chemical binding]; other site 858619004227 catalytic site [active] 858619004228 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 858619004229 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 858619004230 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 858619004231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 858619004232 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 858619004233 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 858619004234 putative substrate binding pocket [chemical binding]; other site 858619004235 dimer interface [polypeptide binding]; other site 858619004236 phosphate binding site [ion binding]; other site 858619004237 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 858619004238 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 858619004239 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 858619004240 GIY-YIG motif/motif A; other site 858619004241 active site 858619004242 catalytic site [active] 858619004243 putative DNA binding site [nucleotide binding]; other site 858619004244 metal binding site [ion binding]; metal-binding site 858619004245 UvrB/uvrC motif; Region: UVR; pfam02151 858619004246 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 858619004247 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 858619004248 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 858619004249 homopentamer interface [polypeptide binding]; other site 858619004250 active site 858619004251 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 858619004252 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 858619004253 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 858619004254 dimerization interface [polypeptide binding]; other site 858619004255 active site 858619004256 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 858619004257 Lumazine binding domain; Region: Lum_binding; pfam00677 858619004258 Lumazine binding domain; Region: Lum_binding; pfam00677 858619004259 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 858619004260 catalytic motif [active] 858619004261 Zn binding site [ion binding]; other site 858619004262 RibD C-terminal domain; Region: RibD_C; pfam01872 858619004263 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 858619004264 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 858619004265 substrate binding site [chemical binding]; other site 858619004266 hexamer interface [polypeptide binding]; other site 858619004267 metal binding site [ion binding]; metal-binding site 858619004268 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 858619004269 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 858619004270 active site 858619004271 dimer interface [polypeptide binding]; other site 858619004272 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 858619004273 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 858619004274 active site 858619004275 FMN binding site [chemical binding]; other site 858619004276 substrate binding site [chemical binding]; other site 858619004277 3Fe-4S cluster binding site [ion binding]; other site 858619004278 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 858619004279 domain_subunit interface; other site 858619004280 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 858619004281 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 858619004282 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 858619004283 FAD binding pocket [chemical binding]; other site 858619004284 FAD binding motif [chemical binding]; other site 858619004285 catalytic residues [active] 858619004286 NAD binding pocket [chemical binding]; other site 858619004287 phosphate binding motif [ion binding]; other site 858619004288 beta-alpha-beta structure motif; other site 858619004289 Protein of unknown function (DUF664); Region: DUF664; pfam04978 858619004290 DinB superfamily; Region: DinB_2; pfam12867 858619004291 NusB family; Region: NusB; pfam01029 858619004292 16S rRNA methyltransferase B; Provisional; Region: PRK14902 858619004293 putative RNA binding site [nucleotide binding]; other site 858619004294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619004295 S-adenosylmethionine binding site [chemical binding]; other site 858619004296 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 858619004297 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 858619004298 putative active site [active] 858619004299 substrate binding site [chemical binding]; other site 858619004300 putative cosubstrate binding site; other site 858619004301 catalytic site [active] 858619004302 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 858619004303 substrate binding site [chemical binding]; other site 858619004304 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 858619004305 active site 858619004306 catalytic residues [active] 858619004307 metal binding site [ion binding]; metal-binding site 858619004308 primosome assembly protein PriA; Provisional; Region: PRK14873 858619004309 S-adenosylmethionine synthetase; Validated; Region: PRK05250 858619004310 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 858619004311 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 858619004312 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 858619004313 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 858619004314 Flavoprotein; Region: Flavoprotein; pfam02441 858619004315 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 858619004316 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 858619004317 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 858619004318 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 858619004319 catalytic site [active] 858619004320 G-X2-G-X-G-K; other site 858619004321 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 858619004322 active site 858619004323 dimer interface [polypeptide binding]; other site 858619004324 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 858619004325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619004326 ATP-grasp domain; Region: ATP-grasp_4; cl17255 858619004327 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 858619004328 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619004329 ATP-grasp domain; Region: ATP-grasp_4; cl17255 858619004330 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 858619004331 IMP binding site; other site 858619004332 dimer interface [polypeptide binding]; other site 858619004333 interdomain contacts; other site 858619004334 partial ornithine binding site; other site 858619004335 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 858619004336 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 858619004337 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 858619004338 catalytic site [active] 858619004339 subunit interface [polypeptide binding]; other site 858619004340 dihydroorotase; Validated; Region: pyrC; PRK09357 858619004341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 858619004342 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 858619004343 active site 858619004344 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 858619004345 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 858619004346 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 858619004347 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 858619004348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619004349 active site 858619004350 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 858619004351 elongation factor P; Validated; Region: PRK00529 858619004352 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 858619004353 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 858619004354 RNA binding site [nucleotide binding]; other site 858619004355 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 858619004356 RNA binding site [nucleotide binding]; other site 858619004357 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 858619004358 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 858619004359 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 858619004360 active site 858619004361 Dehydroquinase class II; Region: DHquinase_II; pfam01220 858619004362 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 858619004363 trimer interface [polypeptide binding]; other site 858619004364 active site 858619004365 dimer interface [polypeptide binding]; other site 858619004366 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 858619004367 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 858619004368 ADP binding site [chemical binding]; other site 858619004369 magnesium binding site [ion binding]; other site 858619004370 putative shikimate binding site; other site 858619004371 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 858619004372 active site 858619004373 dimer interface [polypeptide binding]; other site 858619004374 metal binding site [ion binding]; metal-binding site 858619004375 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 858619004376 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 858619004377 Tetramer interface [polypeptide binding]; other site 858619004378 active site 858619004379 FMN-binding site [chemical binding]; other site 858619004380 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 858619004381 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 858619004382 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 858619004383 shikimate binding site; other site 858619004384 NAD(P) binding site [chemical binding]; other site 858619004385 YceG-like family; Region: YceG; pfam02618 858619004386 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 858619004387 dimerization interface [polypeptide binding]; other site 858619004388 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 858619004389 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 858619004390 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 858619004391 motif 1; other site 858619004392 active site 858619004393 motif 2; other site 858619004394 motif 3; other site 858619004395 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 858619004396 recombination factor protein RarA; Reviewed; Region: PRK13342 858619004397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619004398 Walker A motif; other site 858619004399 ATP binding site [chemical binding]; other site 858619004400 Walker B motif; other site 858619004401 arginine finger; other site 858619004402 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 858619004403 Phosphotransferase enzyme family; Region: APH; pfam01636 858619004404 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 858619004405 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 858619004406 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 858619004407 dimer interface [polypeptide binding]; other site 858619004408 anticodon binding site; other site 858619004409 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 858619004410 homodimer interface [polypeptide binding]; other site 858619004411 motif 1; other site 858619004412 active site 858619004413 motif 2; other site 858619004414 GAD domain; Region: GAD; pfam02938 858619004415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 858619004416 active site 858619004417 motif 3; other site 858619004418 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 858619004419 active site 858619004420 catalytic site [active] 858619004421 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 858619004422 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 858619004423 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 858619004424 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 858619004425 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 858619004426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619004427 catalytic residue [active] 858619004428 polynucleotide kinase; Provisional; Region: pseT; PHA02530 858619004429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619004430 active site 858619004431 motif I; other site 858619004432 motif II; other site 858619004433 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 858619004434 active site 858619004435 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 858619004436 choline dehydrogenase; Validated; Region: PRK02106 858619004437 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 858619004438 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 858619004439 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 858619004440 NAD(P) binding site [chemical binding]; other site 858619004441 catalytic residues [active] 858619004442 BCCT family transporter; Region: BCCT; cl00569 858619004443 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 858619004444 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 858619004445 dimer interface [polypeptide binding]; other site 858619004446 motif 1; other site 858619004447 active site 858619004448 motif 2; other site 858619004449 motif 3; other site 858619004450 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 858619004451 anticodon binding site; other site 858619004452 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 858619004453 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 858619004454 active site 858619004455 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 858619004456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 858619004457 Zn2+ binding site [ion binding]; other site 858619004458 Mg2+ binding site [ion binding]; other site 858619004459 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 858619004460 synthetase active site [active] 858619004461 NTP binding site [chemical binding]; other site 858619004462 metal binding site [ion binding]; metal-binding site 858619004463 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 858619004464 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 858619004465 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619004466 active site 858619004467 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 858619004468 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 858619004469 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 858619004470 Protein export membrane protein; Region: SecD_SecF; pfam02355 858619004471 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 858619004472 Protein export membrane protein; Region: SecD_SecF; cl14618 858619004473 Preprotein translocase subunit; Region: YajC; pfam02699 858619004474 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 858619004475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619004476 Walker A motif; other site 858619004477 ATP binding site [chemical binding]; other site 858619004478 Walker B motif; other site 858619004479 arginine finger; other site 858619004480 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 858619004481 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 858619004482 RuvA N terminal domain; Region: RuvA_N; pfam01330 858619004483 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 858619004484 active site 858619004485 putative DNA-binding cleft [nucleotide binding]; other site 858619004486 dimer interface [polypeptide binding]; other site 858619004487 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 858619004488 hypothetical protein; Validated; Region: PRK00110 858619004489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 858619004490 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 858619004491 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 858619004492 predicted active site [active] 858619004493 catalytic triad [active] 858619004494 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 858619004495 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 858619004496 active site 858619004497 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 858619004498 catalytic triad [active] 858619004499 dimer interface [polypeptide binding]; other site 858619004500 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 858619004501 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 858619004502 active site 858619004503 multimer interface [polypeptide binding]; other site 858619004504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 858619004505 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 858619004506 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 858619004507 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 858619004508 putative acyl-acceptor binding pocket; other site 858619004509 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 858619004510 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 858619004511 nucleotide binding site/active site [active] 858619004512 HIT family signature motif; other site 858619004513 catalytic residue [active] 858619004514 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 858619004515 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 858619004516 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 858619004517 active site 858619004518 dimer interface [polypeptide binding]; other site 858619004519 motif 1; other site 858619004520 motif 2; other site 858619004521 motif 3; other site 858619004522 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 858619004523 anticodon binding site; other site 858619004524 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 858619004525 Protein of unknown function (DUF461); Region: DUF461; pfam04314 858619004526 CopC domain; Region: CopC; pfam04234 858619004527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 858619004528 active site 858619004529 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 858619004530 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 858619004531 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 858619004532 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 858619004533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619004534 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 858619004535 substrate binding site [chemical binding]; other site 858619004536 active site 858619004537 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 858619004538 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 858619004539 catalytic site [active] 858619004540 putative active site [active] 858619004541 putative substrate binding site [chemical binding]; other site 858619004542 HRDC domain; Region: HRDC; cl02578 858619004543 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 858619004544 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 858619004545 TPP-binding site; other site 858619004546 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 858619004547 PYR/PP interface [polypeptide binding]; other site 858619004548 dimer interface [polypeptide binding]; other site 858619004549 TPP binding site [chemical binding]; other site 858619004550 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 858619004551 Methyltransferase domain; Region: Methyltransf_26; pfam13659 858619004552 S-adenosylmethionine binding site [chemical binding]; other site 858619004553 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 858619004554 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 858619004555 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 858619004556 trimer interface [polypeptide binding]; other site 858619004557 active site 858619004558 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 858619004559 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 858619004560 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 858619004561 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 858619004562 active site 858619004563 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 858619004564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 858619004565 nucleotide binding site [chemical binding]; other site 858619004566 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 858619004567 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 858619004568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619004569 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 858619004570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 858619004571 DNA binding residues [nucleotide binding] 858619004572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619004573 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 858619004574 ATP binding site [chemical binding]; other site 858619004575 putative Mg++ binding site [ion binding]; other site 858619004576 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 858619004577 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 858619004578 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 858619004579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619004580 S-adenosylmethionine binding site [chemical binding]; other site 858619004581 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 858619004582 dimerization interface [polypeptide binding]; other site 858619004583 putative tRNAtyr binding site [nucleotide binding]; other site 858619004584 putative active site [active] 858619004585 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 858619004586 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 858619004587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619004588 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 858619004589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 858619004590 DNA binding residues [nucleotide binding] 858619004591 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 858619004592 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 858619004593 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 858619004594 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 858619004595 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 858619004596 NAD binding site [chemical binding]; other site 858619004597 homodimer interface [polypeptide binding]; other site 858619004598 active site 858619004599 substrate binding site [chemical binding]; other site 858619004600 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 858619004601 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 858619004602 PAC2 family; Region: PAC2; pfam09754 858619004603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619004604 ATP binding site [chemical binding]; other site 858619004605 putative Mg++ binding site [ion binding]; other site 858619004606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619004607 nucleotide binding region [chemical binding]; other site 858619004608 ATP-binding site [chemical binding]; other site 858619004609 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 858619004610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619004611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619004612 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 858619004613 dimerization interface [polypeptide binding]; other site 858619004614 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 858619004615 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 858619004616 dimer interface [polypeptide binding]; other site 858619004617 decamer (pentamer of dimers) interface [polypeptide binding]; other site 858619004618 catalytic triad [active] 858619004619 peroxidatic and resolving cysteines [active] 858619004620 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 858619004621 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 858619004622 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 858619004623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619004624 ATP binding site [chemical binding]; other site 858619004625 putative Mg++ binding site [ion binding]; other site 858619004626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619004627 nucleotide binding region [chemical binding]; other site 858619004628 ATP-binding site [chemical binding]; other site 858619004629 Helicase associated domain (HA2); Region: HA2; pfam04408 858619004630 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 858619004631 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 858619004632 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 858619004633 ATP cone domain; Region: ATP-cone; pfam03477 858619004634 LexA repressor; Validated; Region: PRK00215 858619004635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619004636 putative DNA binding site [nucleotide binding]; other site 858619004637 putative Zn2+ binding site [ion binding]; other site 858619004638 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 858619004639 Catalytic site [active] 858619004640 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 858619004641 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 858619004642 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 858619004643 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 858619004644 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 858619004645 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 858619004646 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 858619004647 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 858619004648 regulatory protein interface [polypeptide binding]; other site 858619004649 active site 858619004650 regulatory phosphorylation site [posttranslational modification]; other site 858619004651 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 858619004652 GTPases [General function prediction only]; Region: HflX; COG2262 858619004653 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 858619004654 HflX GTPase family; Region: HflX; cd01878 858619004655 G1 box; other site 858619004656 GTP/Mg2+ binding site [chemical binding]; other site 858619004657 Switch I region; other site 858619004658 G2 box; other site 858619004659 G3 box; other site 858619004660 Switch II region; other site 858619004661 G4 box; other site 858619004662 G5 box; other site 858619004663 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 858619004664 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 858619004665 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 858619004666 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 858619004667 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 858619004668 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 858619004669 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 858619004670 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 858619004671 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 858619004672 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 858619004673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 858619004674 FeS/SAM binding site; other site 858619004675 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 858619004676 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 858619004677 Walker A/P-loop; other site 858619004678 ATP binding site [chemical binding]; other site 858619004679 Q-loop/lid; other site 858619004680 ABC transporter signature motif; other site 858619004681 Walker B; other site 858619004682 D-loop; other site 858619004683 H-loop/switch region; other site 858619004684 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 858619004685 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 858619004686 substrate binding pocket [chemical binding]; other site 858619004687 membrane-bound complex binding site; other site 858619004688 hinge residues; other site 858619004689 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 858619004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619004691 dimer interface [polypeptide binding]; other site 858619004692 conserved gate region; other site 858619004693 putative PBP binding loops; other site 858619004694 ABC-ATPase subunit interface; other site 858619004695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 858619004696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619004697 dimer interface [polypeptide binding]; other site 858619004698 conserved gate region; other site 858619004699 putative PBP binding loops; other site 858619004700 ABC-ATPase subunit interface; other site 858619004701 recombination regulator RecX; Reviewed; Region: recX; PRK00117 858619004702 recombinase A; Provisional; Region: recA; PRK09354 858619004703 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 858619004704 hexamer interface [polypeptide binding]; other site 858619004705 Walker A motif; other site 858619004706 ATP binding site [chemical binding]; other site 858619004707 Walker B motif; other site 858619004708 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 858619004709 BioY family; Region: BioY; pfam02632 858619004710 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 858619004711 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 858619004712 Walker A/P-loop; other site 858619004713 ATP binding site [chemical binding]; other site 858619004714 Q-loop/lid; other site 858619004715 ABC transporter signature motif; other site 858619004716 Walker B; other site 858619004717 D-loop; other site 858619004718 H-loop/switch region; other site 858619004719 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 858619004720 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619004721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619004722 non-specific DNA binding site [nucleotide binding]; other site 858619004723 salt bridge; other site 858619004724 sequence-specific DNA binding site [nucleotide binding]; other site 858619004725 Competence-damaged protein; Region: CinA; pfam02464 858619004726 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 858619004727 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 858619004728 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 858619004729 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 858619004730 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 858619004731 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 858619004732 TIGR03085 family protein; Region: TIGR03085 858619004733 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 858619004734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 858619004735 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 858619004736 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 858619004737 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 858619004738 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 858619004739 dimer interface [polypeptide binding]; other site 858619004740 active site 858619004741 catalytic residue [active] 858619004742 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 858619004743 dihydrodipicolinate reductase; Provisional; Region: PRK00048 858619004744 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 858619004745 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 858619004746 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 858619004747 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 858619004748 oligomer interface [polypeptide binding]; other site 858619004749 RNA binding site [nucleotide binding]; other site 858619004750 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 858619004751 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 858619004752 RNase E interface [polypeptide binding]; other site 858619004753 trimer interface [polypeptide binding]; other site 858619004754 active site 858619004755 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 858619004756 putative nucleic acid binding region [nucleotide binding]; other site 858619004757 G-X-X-G motif; other site 858619004758 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 858619004759 RNA binding site [nucleotide binding]; other site 858619004760 domain interface; other site 858619004761 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 858619004762 16S/18S rRNA binding site [nucleotide binding]; other site 858619004763 S13e-L30e interaction site [polypeptide binding]; other site 858619004764 25S rRNA binding site [nucleotide binding]; other site 858619004765 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 858619004766 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 858619004767 active site 858619004768 Riboflavin kinase; Region: Flavokinase; pfam01687 858619004769 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 858619004770 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 858619004771 RNA binding site [nucleotide binding]; other site 858619004772 active site 858619004773 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 858619004774 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 858619004775 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 858619004776 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 858619004777 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 858619004778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 858619004779 active site 858619004780 metal binding site [ion binding]; metal-binding site 858619004781 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 858619004782 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 858619004783 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 858619004784 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 858619004785 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 858619004786 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 858619004787 G1 box; other site 858619004788 putative GEF interaction site [polypeptide binding]; other site 858619004789 GTP/Mg2+ binding site [chemical binding]; other site 858619004790 Switch I region; other site 858619004791 G2 box; other site 858619004792 G3 box; other site 858619004793 Switch II region; other site 858619004794 G4 box; other site 858619004795 G5 box; other site 858619004796 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 858619004797 Translation-initiation factor 2; Region: IF-2; pfam11987 858619004798 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 858619004799 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 858619004800 putative RNA binding cleft [nucleotide binding]; other site 858619004801 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 858619004802 NusA N-terminal domain; Region: NusA_N; pfam08529 858619004803 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 858619004804 RNA binding site [nucleotide binding]; other site 858619004805 homodimer interface [polypeptide binding]; other site 858619004806 NusA-like KH domain; Region: KH_5; pfam13184 858619004807 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 858619004808 G-X-X-G motif; other site 858619004809 ribosome maturation protein RimP; Reviewed; Region: PRK00092 858619004810 Sm and related proteins; Region: Sm_like; cl00259 858619004811 prolyl-tRNA synthetase; Provisional; Region: PRK09194 858619004812 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 858619004813 dimer interface [polypeptide binding]; other site 858619004814 motif 1; other site 858619004815 active site 858619004816 motif 2; other site 858619004817 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 858619004818 putative deacylase active site [active] 858619004819 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 858619004820 active site 858619004821 motif 3; other site 858619004822 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 858619004823 anticodon binding site; other site 858619004824 hypothetical protein; Validated; Region: PRK02101 858619004825 AAA ATPase domain; Region: AAA_16; pfam13191 858619004826 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 858619004827 homodimer interface [polypeptide binding]; other site 858619004828 active site 858619004829 SAM binding site [chemical binding]; other site 858619004830 malate:quinone oxidoreductase; Validated; Region: PRK05257 858619004831 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 858619004832 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 858619004833 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 858619004834 mycothione reductase; Reviewed; Region: PRK07846 858619004835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619004836 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 858619004837 short chain dehydrogenase; Provisional; Region: PRK07832 858619004838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619004839 NAD(P) binding site [chemical binding]; other site 858619004840 active site 858619004841 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 858619004842 proline/glycine betaine transporter; Provisional; Region: PRK10642 858619004843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619004844 putative substrate translocation pore; other site 858619004845 Secretory lipase; Region: LIP; pfam03583 858619004846 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 858619004847 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 858619004848 Walker A/P-loop; other site 858619004849 ATP binding site [chemical binding]; other site 858619004850 Q-loop/lid; other site 858619004851 ABC transporter signature motif; other site 858619004852 Walker B; other site 858619004853 D-loop; other site 858619004854 H-loop/switch region; other site 858619004855 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 858619004856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619004857 putative PBP binding loops; other site 858619004858 ABC-ATPase subunit interface; other site 858619004859 NMT1/THI5 like; Region: NMT1; pfam09084 858619004860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 858619004861 substrate binding pocket [chemical binding]; other site 858619004862 membrane-bound complex binding site; other site 858619004863 hinge residues; other site 858619004864 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 858619004865 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 858619004866 active site 858619004867 non-prolyl cis peptide bond; other site 858619004868 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 858619004869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619004870 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 858619004871 Walker A motif; other site 858619004872 ATP binding site [chemical binding]; other site 858619004873 Walker B motif; other site 858619004874 Uncharacterized conserved protein [Function unknown]; Region: COG3410 858619004875 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 858619004876 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 858619004877 Walker A motif; other site 858619004878 ATP binding site [chemical binding]; other site 858619004879 Walker B motif; other site 858619004880 Uncharacterized conserved protein [Function unknown]; Region: COG3410 858619004881 primosome assembly protein PriA; Validated; Region: PRK05580 858619004882 Nuclease-related domain; Region: NERD; pfam08378 858619004883 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 858619004884 active site 858619004885 ATP binding site [chemical binding]; other site 858619004886 substrate binding site [chemical binding]; other site 858619004887 activation loop (A-loop); other site 858619004888 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 858619004889 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 858619004890 active site 858619004891 ATP binding site [chemical binding]; other site 858619004892 substrate binding site [chemical binding]; other site 858619004893 activation loop (A-loop); other site 858619004894 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 858619004895 Methyltransferase domain; Region: Methyltransf_26; pfam13659 858619004896 primosomal protein DnaI; Reviewed; Region: PRK08939 858619004897 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 858619004898 DEAD-like helicases superfamily; Region: DEXDc; smart00487 858619004899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619004900 ATP binding site [chemical binding]; other site 858619004901 putative Mg++ binding site [ion binding]; other site 858619004902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619004903 nucleotide binding region [chemical binding]; other site 858619004904 ATP-binding site [chemical binding]; other site 858619004905 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 858619004906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619004907 homodimer interface [polypeptide binding]; other site 858619004908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619004909 catalytic residue [active] 858619004910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619004911 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619004912 hypothetical protein; Provisional; Region: PRK06062 858619004913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619004914 inhibitor-cofactor binding pocket; inhibition site 858619004915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619004916 catalytic residue [active] 858619004917 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 858619004918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 858619004919 D-xylulose kinase; Region: XylB; TIGR01312 858619004920 nucleotide binding site [chemical binding]; other site 858619004921 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 858619004922 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 858619004923 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 858619004924 polyol permease family; Region: 2A0118; TIGR00897 858619004925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619004926 putative substrate translocation pore; other site 858619004927 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 858619004928 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 858619004929 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 858619004930 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619004931 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619004932 intersubunit interface [polypeptide binding]; other site 858619004933 TM2 domain; Region: TM2; pfam05154 858619004934 TM2 domain; Region: TM2; pfam05154 858619004935 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 858619004936 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 858619004937 Uncharacterized conserved protein [Function unknown]; Region: COG2128 858619004938 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 858619004939 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 858619004940 active site 858619004941 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 858619004942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 858619004943 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 858619004944 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 858619004945 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 858619004946 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 858619004947 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 858619004948 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 858619004949 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 858619004950 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 858619004951 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 858619004952 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 858619004953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 858619004954 FeS/SAM binding site; other site 858619004955 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 858619004956 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 858619004957 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 858619004958 ribosome recycling factor; Reviewed; Region: frr; PRK00083 858619004959 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 858619004960 hinge region; other site 858619004961 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 858619004962 putative nucleotide binding site [chemical binding]; other site 858619004963 uridine monophosphate binding site [chemical binding]; other site 858619004964 homohexameric interface [polypeptide binding]; other site 858619004965 elongation factor Ts; Provisional; Region: tsf; PRK09377 858619004966 UBA/TS-N domain; Region: UBA; pfam00627 858619004967 Elongation factor TS; Region: EF_TS; pfam00889 858619004968 Elongation factor TS; Region: EF_TS; pfam00889 858619004969 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 858619004970 rRNA interaction site [nucleotide binding]; other site 858619004971 S8 interaction site; other site 858619004972 putative laminin-1 binding site; other site 858619004973 Peptidase family M23; Region: Peptidase_M23; pfam01551 858619004974 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 858619004975 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 858619004976 active site 858619004977 DNA binding site [nucleotide binding] 858619004978 Int/Topo IB signature motif; other site 858619004979 DNA protecting protein DprA; Region: dprA; TIGR00732 858619004980 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 858619004981 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 858619004982 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 858619004983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619004984 Walker A motif; other site 858619004985 ATP binding site [chemical binding]; other site 858619004986 Walker B motif; other site 858619004987 hypothetical protein; Reviewed; Region: PRK12497 858619004988 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 858619004989 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 858619004990 RNA/DNA hybrid binding site [nucleotide binding]; other site 858619004991 active site 858619004992 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 858619004993 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 858619004994 Catalytic site [active] 858619004995 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 858619004996 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 858619004997 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 858619004998 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 858619004999 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 858619005000 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 858619005001 RNA binding site [nucleotide binding]; other site 858619005002 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 858619005003 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 858619005004 RimM N-terminal domain; Region: RimM; pfam01782 858619005005 glutamate dehydrogenase; Provisional; Region: PRK09414 858619005006 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 858619005007 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 858619005008 NAD(P) binding site [chemical binding]; other site 858619005009 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 858619005010 signal recognition particle protein; Provisional; Region: PRK10867 858619005011 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 858619005012 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 858619005013 P loop; other site 858619005014 GTP binding site [chemical binding]; other site 858619005015 Signal peptide binding domain; Region: SRP_SPB; pfam02978 858619005016 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 858619005017 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 858619005018 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 858619005019 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 858619005020 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 858619005021 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 858619005022 Walker A/P-loop; other site 858619005023 ATP binding site [chemical binding]; other site 858619005024 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 858619005025 ABC transporter signature motif; other site 858619005026 Walker B; other site 858619005027 D-loop; other site 858619005028 H-loop/switch region; other site 858619005029 acylphosphatase; Provisional; Region: PRK14422 858619005030 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 858619005031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619005032 active site 858619005033 metal binding site [ion binding]; metal-binding site 858619005034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619005035 Coenzyme A binding pocket [chemical binding]; other site 858619005036 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 858619005037 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 858619005038 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 858619005039 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619005040 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619005041 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 858619005042 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 858619005043 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 858619005044 DNA binding site [nucleotide binding] 858619005045 catalytic residue [active] 858619005046 H2TH interface [polypeptide binding]; other site 858619005047 putative catalytic residues [active] 858619005048 turnover-facilitating residue; other site 858619005049 intercalation triad [nucleotide binding]; other site 858619005050 8OG recognition residue [nucleotide binding]; other site 858619005051 putative reading head residues; other site 858619005052 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 858619005053 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 858619005054 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 858619005055 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 858619005056 dimerization interface [polypeptide binding]; other site 858619005057 active site 858619005058 metal binding site [ion binding]; metal-binding site 858619005059 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 858619005060 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 858619005061 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 858619005062 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 858619005063 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 858619005064 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 858619005065 active site 858619005066 (T/H)XGH motif; other site 858619005067 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 858619005068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 858619005069 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 858619005070 lipoyl-biotinyl attachment site [posttranslational modification]; other site 858619005071 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 858619005072 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 858619005073 generic binding surface II; other site 858619005074 ssDNA binding site; other site 858619005075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619005076 ATP binding site [chemical binding]; other site 858619005077 putative Mg++ binding site [ion binding]; other site 858619005078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619005079 nucleotide binding region [chemical binding]; other site 858619005080 ATP-binding site [chemical binding]; other site 858619005081 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 858619005082 DAK2 domain; Region: Dak2; pfam02734 858619005083 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 858619005084 ligand binding site [chemical binding]; other site 858619005085 active site 858619005086 UGI interface [polypeptide binding]; other site 858619005087 catalytic site [active] 858619005088 thiamine monophosphate kinase; Provisional; Region: PRK05731 858619005089 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 858619005090 ATP binding site [chemical binding]; other site 858619005091 dimerization interface [polypeptide binding]; other site 858619005092 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 858619005093 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 858619005094 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 858619005095 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 858619005096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 858619005097 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 858619005098 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 858619005099 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 858619005100 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 858619005101 active site 858619005102 Ap6A binding site [chemical binding]; other site 858619005103 nudix motif; other site 858619005104 metal binding site [ion binding]; metal-binding site 858619005105 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619005106 catalytic core [active] 858619005107 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 858619005108 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 858619005109 substrate binding site [chemical binding]; other site 858619005110 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 858619005111 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 858619005112 substrate binding site [chemical binding]; other site 858619005113 ligand binding site [chemical binding]; other site 858619005114 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 858619005115 Transcriptional regulator [Transcription]; Region: IclR; COG1414 858619005116 Bacterial transcriptional regulator; Region: IclR; pfam01614 858619005117 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 858619005118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619005119 catalytic core [active] 858619005120 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 858619005121 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 858619005122 active site 858619005123 HIGH motif; other site 858619005124 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 858619005125 active site 858619005126 KMSKS motif; other site 858619005127 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 858619005128 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 858619005129 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 858619005130 NAD(P) binding site [chemical binding]; other site 858619005131 classical (c) SDRs; Region: SDR_c; cd05233 858619005132 NAD(P) binding site [chemical binding]; other site 858619005133 active site 858619005134 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 858619005135 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 858619005136 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 858619005137 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 858619005138 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 858619005139 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 858619005140 active site 858619005141 catalytic site [active] 858619005142 substrate binding site [chemical binding]; other site 858619005143 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 858619005144 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 858619005145 ligand binding site [chemical binding]; other site 858619005146 flexible hinge region; other site 858619005147 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 858619005148 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 858619005149 metal binding triad; other site 858619005150 Predicted transcriptional regulators [Transcription]; Region: COG1695 858619005151 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 858619005152 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 858619005153 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 858619005154 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 858619005155 active site 858619005156 FMN binding site [chemical binding]; other site 858619005157 2,4-decadienoyl-CoA binding site; other site 858619005158 catalytic residue [active] 858619005159 4Fe-4S cluster binding site [ion binding]; other site 858619005160 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 858619005161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619005162 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619005163 active site 858619005164 Lipase (class 2); Region: Lipase_2; pfam01674 858619005165 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 858619005166 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 858619005167 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 858619005168 tartrate dehydrogenase; Region: TTC; TIGR02089 858619005169 Iron permease FTR1 family; Region: FTR1; cl00475 858619005170 Imelysin; Region: Peptidase_M75; pfam09375 858619005171 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 858619005172 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 858619005173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619005175 putative substrate translocation pore; other site 858619005176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 858619005177 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 858619005178 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 858619005179 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 858619005180 ligand binding site [chemical binding]; other site 858619005181 NAD binding site [chemical binding]; other site 858619005182 dimerization interface [polypeptide binding]; other site 858619005183 catalytic site [active] 858619005184 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 858619005185 putative L-serine binding site [chemical binding]; other site 858619005186 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 858619005187 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 858619005188 ketol-acid reductoisomerase; Provisional; Region: PRK05479 858619005189 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 858619005190 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 858619005191 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 858619005192 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 858619005193 putative valine binding site [chemical binding]; other site 858619005194 dimer interface [polypeptide binding]; other site 858619005195 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 858619005196 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 858619005197 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 858619005198 PYR/PP interface [polypeptide binding]; other site 858619005199 dimer interface [polypeptide binding]; other site 858619005200 TPP binding site [chemical binding]; other site 858619005201 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 858619005202 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 858619005203 TPP-binding site [chemical binding]; other site 858619005204 dimer interface [polypeptide binding]; other site 858619005205 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 858619005206 Mechanosensitive ion channel; Region: MS_channel; pfam00924 858619005207 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 858619005208 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 858619005209 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 858619005210 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 858619005211 putative NAD(P) binding site [chemical binding]; other site 858619005212 putative active site [active] 858619005213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005214 Walker A/P-loop; other site 858619005215 ATP binding site [chemical binding]; other site 858619005216 Q-loop/lid; other site 858619005217 ABC transporter; Region: ABC_tran; pfam00005 858619005218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005219 ABC transporter signature motif; other site 858619005220 Walker B; other site 858619005221 D-loop; other site 858619005222 H-loop/switch region; other site 858619005223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005224 Walker A/P-loop; other site 858619005225 ATP binding site [chemical binding]; other site 858619005226 Q-loop/lid; other site 858619005227 ABC transporter signature motif; other site 858619005228 Walker B; other site 858619005229 D-loop; other site 858619005230 H-loop/switch region; other site 858619005231 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 858619005232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619005233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 858619005234 dimerization interface [polypeptide binding]; other site 858619005235 LysE type translocator; Region: LysE; cl00565 858619005236 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 858619005237 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 858619005238 putative dimer interface [polypeptide binding]; other site 858619005239 N-terminal domain interface [polypeptide binding]; other site 858619005240 putative substrate binding pocket (H-site) [chemical binding]; other site 858619005241 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 858619005242 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 858619005243 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 858619005244 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 858619005245 ligand binding site [chemical binding]; other site 858619005246 homodimer interface [polypeptide binding]; other site 858619005247 NAD(P) binding site [chemical binding]; other site 858619005248 trimer interface B [polypeptide binding]; other site 858619005249 trimer interface A [polypeptide binding]; other site 858619005250 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 858619005251 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 858619005252 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 858619005253 GatB domain; Region: GatB_Yqey; smart00845 858619005254 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 858619005255 Sodium Bile acid symporter family; Region: SBF; cl17470 858619005256 6-phosphofructokinase; Provisional; Region: PRK03202 858619005257 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 858619005258 active site 858619005259 ADP/pyrophosphate binding site [chemical binding]; other site 858619005260 dimerization interface [polypeptide binding]; other site 858619005261 allosteric effector site; other site 858619005262 fructose-1,6-bisphosphate binding site; other site 858619005263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619005265 putative substrate translocation pore; other site 858619005266 NUDIX domain; Region: NUDIX; pfam00293 858619005267 nudix motif; other site 858619005268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619005269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005270 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 858619005271 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 858619005272 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 858619005273 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 858619005274 threonine dehydratase; Reviewed; Region: PRK09224 858619005275 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 858619005276 tetramer interface [polypeptide binding]; other site 858619005277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619005278 catalytic residue [active] 858619005279 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 858619005280 putative Ile/Val binding site [chemical binding]; other site 858619005281 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 858619005282 putative Ile/Val binding site [chemical binding]; other site 858619005283 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 858619005284 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 858619005285 active site 858619005286 catalytic site [active] 858619005287 substrate binding site [chemical binding]; other site 858619005288 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 858619005289 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 858619005290 nucleotide binding pocket [chemical binding]; other site 858619005291 K-X-D-G motif; other site 858619005292 catalytic site [active] 858619005293 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 858619005294 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 858619005295 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 858619005296 Dimer interface [polypeptide binding]; other site 858619005297 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 858619005298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005299 Walker A/P-loop; other site 858619005300 ATP binding site [chemical binding]; other site 858619005301 Q-loop/lid; other site 858619005302 ABC transporter signature motif; other site 858619005303 Walker B; other site 858619005304 D-loop; other site 858619005305 H-loop/switch region; other site 858619005306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619005307 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 858619005308 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 858619005309 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 858619005310 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 858619005311 Ligand Binding Site [chemical binding]; other site 858619005312 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 858619005313 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 858619005314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619005315 catalytic residue [active] 858619005316 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 858619005317 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 858619005318 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 858619005319 Ligand Binding Site [chemical binding]; other site 858619005320 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 858619005321 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 858619005322 Ligand binding site [chemical binding]; other site 858619005323 Electron transfer flavoprotein domain; Region: ETF; pfam01012 858619005324 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 858619005325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005326 Walker A/P-loop; other site 858619005327 ATP binding site [chemical binding]; other site 858619005328 ABC transporter signature motif; other site 858619005329 Walker B; other site 858619005330 D-loop; other site 858619005331 H-loop/switch region; other site 858619005332 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 858619005333 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 858619005334 hypothetical protein; Provisional; Region: PRK03298 858619005335 CD20-like family; Region: CD20; pfam04103 858619005336 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 858619005337 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 858619005338 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 858619005339 gamma subunit interface [polypeptide binding]; other site 858619005340 epsilon subunit interface [polypeptide binding]; other site 858619005341 LBP interface [polypeptide binding]; other site 858619005342 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 858619005343 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 858619005344 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 858619005345 alpha subunit interaction interface [polypeptide binding]; other site 858619005346 Walker A motif; other site 858619005347 ATP binding site [chemical binding]; other site 858619005348 Walker B motif; other site 858619005349 inhibitor binding site; inhibition site 858619005350 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 858619005351 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 858619005352 core domain interface [polypeptide binding]; other site 858619005353 delta subunit interface [polypeptide binding]; other site 858619005354 epsilon subunit interface [polypeptide binding]; other site 858619005355 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 858619005356 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 858619005357 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 858619005358 beta subunit interaction interface [polypeptide binding]; other site 858619005359 Walker A motif; other site 858619005360 ATP binding site [chemical binding]; other site 858619005361 Walker B motif; other site 858619005362 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 858619005363 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 858619005364 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 858619005365 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 858619005366 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 858619005367 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 858619005368 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 858619005369 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 858619005370 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 858619005371 Mg++ binding site [ion binding]; other site 858619005372 putative catalytic motif [active] 858619005373 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 858619005374 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 858619005375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 858619005376 peptide chain release factor 1; Validated; Region: prfA; PRK00591 858619005377 PCRF domain; Region: PCRF; pfam03462 858619005378 RF-1 domain; Region: RF-1; pfam00472 858619005379 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 858619005380 transcription termination factor Rho; Provisional; Region: PRK12608 858619005381 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 858619005382 RNA binding site [nucleotide binding]; other site 858619005383 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 858619005384 multimer interface [polypeptide binding]; other site 858619005385 Walker A motif; other site 858619005386 ATP binding site [chemical binding]; other site 858619005387 Walker B motif; other site 858619005388 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 858619005389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619005390 acyl-activating enzyme (AAE) consensus motif; other site 858619005391 AMP binding site [chemical binding]; other site 858619005392 active site 858619005393 CoA binding site [chemical binding]; other site 858619005394 homoserine kinase; Provisional; Region: PRK01212 858619005395 homoserine dehydrogenase; Provisional; Region: PRK06349 858619005396 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 858619005397 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 858619005398 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 858619005399 diaminopimelate decarboxylase; Region: lysA; TIGR01048 858619005400 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 858619005401 active site 858619005402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 858619005403 substrate binding site [chemical binding]; other site 858619005404 catalytic residues [active] 858619005405 dimer interface [polypeptide binding]; other site 858619005406 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 858619005407 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 858619005408 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 858619005409 active site 858619005410 HIGH motif; other site 858619005411 KMSK motif region; other site 858619005412 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 858619005413 tRNA binding surface [nucleotide binding]; other site 858619005414 anticodon binding site; other site 858619005415 AAA domain; Region: AAA_23; pfam13476 858619005416 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 858619005417 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 858619005418 active site 858619005419 metal binding site [ion binding]; metal-binding site 858619005420 SWIM zinc finger; Region: SWIM; pfam04434 858619005421 SNF2 Helicase protein; Region: DUF3670; pfam12419 858619005422 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 858619005423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619005424 ATP binding site [chemical binding]; other site 858619005425 putative Mg++ binding site [ion binding]; other site 858619005426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619005427 nucleotide binding region [chemical binding]; other site 858619005428 ATP-binding site [chemical binding]; other site 858619005429 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 858619005430 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 858619005431 Na binding site [ion binding]; other site 858619005432 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 858619005433 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 858619005434 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 858619005435 ATP binding site [chemical binding]; other site 858619005436 Mg++ binding site [ion binding]; other site 858619005437 motif III; other site 858619005438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619005439 nucleotide binding region [chemical binding]; other site 858619005440 ATP-binding site [chemical binding]; other site 858619005441 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 858619005442 putative RNA binding site [nucleotide binding]; other site 858619005443 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 858619005444 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 858619005445 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 858619005446 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 858619005447 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 858619005448 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 858619005449 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 858619005450 TPP-binding site [chemical binding]; other site 858619005451 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 858619005452 dimer interface [polypeptide binding]; other site 858619005453 PYR/PP interface [polypeptide binding]; other site 858619005454 TPP binding site [chemical binding]; other site 858619005455 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 858619005456 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 858619005457 oligomer interface [polypeptide binding]; other site 858619005458 metal binding site [ion binding]; metal-binding site 858619005459 metal binding site [ion binding]; metal-binding site 858619005460 putative Cl binding site [ion binding]; other site 858619005461 basic sphincter; other site 858619005462 hydrophobic gate; other site 858619005463 periplasmic entrance; other site 858619005464 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 858619005465 PRC-barrel domain; Region: PRC; pfam05239 858619005466 MgtE intracellular N domain; Region: MgtE_N; pfam03448 858619005467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 858619005468 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 858619005469 Domain of unknown function DUF59; Region: DUF59; pfam01883 858619005470 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 858619005471 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 858619005472 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 858619005473 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 858619005474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619005475 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 858619005476 DNA binding residues [nucleotide binding] 858619005477 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 858619005478 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 858619005479 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 858619005480 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 858619005481 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 858619005482 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 858619005483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619005484 S-adenosylmethionine binding site [chemical binding]; other site 858619005485 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 858619005486 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 858619005487 Substrate-binding/catalytic site; other site 858619005488 DivIVA domain; Region: DivI1A_domain; TIGR03544 858619005489 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 858619005490 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 858619005491 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 858619005492 metal binding site [ion binding]; metal-binding site 858619005493 putative dimer interface [polypeptide binding]; other site 858619005494 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 858619005495 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 858619005496 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 858619005497 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 858619005498 putative trimer interface [polypeptide binding]; other site 858619005499 putative CoA binding site [chemical binding]; other site 858619005500 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 858619005501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619005502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619005503 homodimer interface [polypeptide binding]; other site 858619005504 catalytic residue [active] 858619005505 Ferredoxin [Energy production and conversion]; Region: COG1146 858619005506 4Fe-4S binding domain; Region: Fer4; pfam00037 858619005507 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 858619005508 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 858619005509 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 858619005510 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 858619005511 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 858619005512 G1 box; other site 858619005513 GTP/Mg2+ binding site [chemical binding]; other site 858619005514 G2 box; other site 858619005515 Switch I region; other site 858619005516 G3 box; other site 858619005517 Switch II region; other site 858619005518 G4 box; other site 858619005519 G5 box; other site 858619005520 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 858619005521 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 858619005522 Protein of unknown function (DUF402); Region: DUF402; cl00979 858619005523 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619005524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619005525 active site 858619005526 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 858619005527 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 858619005528 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 858619005529 NADH(P)-binding; Region: NAD_binding_10; pfam13460 858619005530 NAD(P) binding site [chemical binding]; other site 858619005531 putative active site [active] 858619005532 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 858619005533 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 858619005534 active site 858619005535 nucleophile elbow; other site 858619005536 Protein of unknown function (DUF808); Region: DUF808; cl01002 858619005537 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 858619005538 putative catalytic site [active] 858619005539 putative metal binding site [ion binding]; other site 858619005540 putative phosphate binding site [ion binding]; other site 858619005541 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 858619005542 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 858619005543 catalytic residues [active] 858619005544 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 858619005545 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 858619005546 putative acyl-acceptor binding pocket; other site 858619005547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 858619005548 Sulfatase; Region: Sulfatase; cl17466 858619005549 Protein of unknown function, DUF488; Region: DUF488; pfam04343 858619005550 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619005551 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 858619005552 catalytic residues [active] 858619005553 catalytic nucleophile [active] 858619005554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005555 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 858619005556 myosin-cross-reactive antigen; Provisional; Region: PRK13977 858619005557 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 858619005558 active site 858619005559 Predicted membrane protein [Function unknown]; Region: COG4325 858619005560 transposase; Provisional; Region: PRK06526 858619005561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619005562 ATP binding site [chemical binding]; other site 858619005563 Walker A motif; other site 858619005564 Walker B motif; other site 858619005565 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619005566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 858619005567 DNA-binding interface [nucleotide binding]; DNA binding site 858619005568 Integrase core domain; Region: rve; pfam00665 858619005569 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619005570 D-lactate dehydrogenase; Provisional; Region: PRK11183 858619005571 FAD binding domain; Region: FAD_binding_4; pfam01565 858619005572 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 858619005573 putative transposase OrfB; Reviewed; Region: PHA02517 858619005574 HTH-like domain; Region: HTH_21; pfam13276 858619005575 Integrase core domain; Region: rve; pfam00665 858619005576 Integrase core domain; Region: rve_3; pfam13683 858619005577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619005578 Transposase; Region: HTH_Tnp_1; pfam01527 858619005579 Integrase core domain; Region: rve; pfam00665 858619005580 Integrase core domain; Region: rve_3; cl15866 858619005581 Transposase; Region: HTH_Tnp_1; cl17663 858619005582 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619005583 MULE transposase domain; Region: MULE; pfam10551 858619005584 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619005585 potential frameshift: common BLAST hit: gi|256832661|ref|YP_003161388.1| transposase IS204/IS1001/IS1096/IS1165 family protein 858619005586 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619005587 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619005588 GTP-binding protein YchF; Reviewed; Region: PRK09601 858619005589 YchF GTPase; Region: YchF; cd01900 858619005590 G1 box; other site 858619005591 GTP/Mg2+ binding site [chemical binding]; other site 858619005592 Switch I region; other site 858619005593 G2 box; other site 858619005594 Switch II region; other site 858619005595 G3 box; other site 858619005596 G4 box; other site 858619005597 G5 box; other site 858619005598 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 858619005599 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 858619005600 Na2 binding site [ion binding]; other site 858619005601 putative substrate binding site 1 [chemical binding]; other site 858619005602 Na binding site 1 [ion binding]; other site 858619005603 putative substrate binding site 2 [chemical binding]; other site 858619005604 Domain of unknown function DUF20; Region: UPF0118; pfam01594 858619005605 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 858619005606 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 858619005607 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 858619005608 generic binding surface II; other site 858619005609 generic binding surface I; other site 858619005610 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 858619005611 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 858619005612 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 858619005613 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 858619005614 putative active site [active] 858619005615 fumarate hydratase; Reviewed; Region: fumC; PRK00485 858619005616 Class II fumarases; Region: Fumarase_classII; cd01362 858619005617 active site 858619005618 tetramer interface [polypeptide binding]; other site 858619005619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005620 Walker A/P-loop; other site 858619005621 ATP binding site [chemical binding]; other site 858619005622 Q-loop/lid; other site 858619005623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005624 ABC transporter signature motif; other site 858619005625 Walker B; other site 858619005626 D-loop; other site 858619005627 H-loop/switch region; other site 858619005628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619005629 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 858619005630 Walker A/P-loop; other site 858619005631 ATP binding site [chemical binding]; other site 858619005632 Q-loop/lid; other site 858619005633 ABC transporter signature motif; other site 858619005634 Walker B; other site 858619005635 D-loop; other site 858619005636 H-loop/switch region; other site 858619005637 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 858619005638 active site 858619005639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 858619005640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619005643 putative substrate translocation pore; other site 858619005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005645 putative substrate translocation pore; other site 858619005646 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 858619005647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619005648 Coenzyme A binding pocket [chemical binding]; other site 858619005649 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 858619005650 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 858619005651 putative active site [active] 858619005652 PhoH-like protein; Region: PhoH; pfam02562 858619005653 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 858619005654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 858619005655 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619005656 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619005657 active site 858619005658 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 858619005659 RNA/DNA hybrid binding site [nucleotide binding]; other site 858619005660 active site 858619005661 enoyl-CoA hydratase; Provisional; Region: PRK06688 858619005662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619005663 substrate binding site [chemical binding]; other site 858619005664 oxyanion hole (OAH) forming residues; other site 858619005665 trimer interface [polypeptide binding]; other site 858619005666 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 858619005667 Isochorismatase family; Region: Isochorismatase; pfam00857 858619005668 catalytic triad [active] 858619005669 conserved cis-peptide bond; other site 858619005670 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 858619005671 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 858619005672 dimer interface [polypeptide binding]; other site 858619005673 active site 858619005674 glycine-pyridoxal phosphate binding site [chemical binding]; other site 858619005675 folate binding site [chemical binding]; other site 858619005676 pantothenate kinase; Provisional; Region: PRK05439 858619005677 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 858619005678 ATP-binding site [chemical binding]; other site 858619005679 CoA-binding site [chemical binding]; other site 858619005680 Mg2+-binding site [ion binding]; other site 858619005681 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 858619005682 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 858619005683 catalytic residue [active] 858619005684 putative FPP diphosphate binding site; other site 858619005685 putative FPP binding hydrophobic cleft; other site 858619005686 dimer interface [polypeptide binding]; other site 858619005687 putative IPP diphosphate binding site; other site 858619005688 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 858619005689 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 858619005690 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 858619005691 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 858619005692 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 858619005693 Predicted membrane protein [Function unknown]; Region: COG4760 858619005694 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 858619005695 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 858619005696 NAD(P) binding site [chemical binding]; other site 858619005697 catalytic residues [active] 858619005698 Methyltransferase domain; Region: Methyltransf_31; pfam13847 858619005699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619005700 S-adenosylmethionine binding site [chemical binding]; other site 858619005701 short chain dehydrogenase; Provisional; Region: PRK08219 858619005702 classical (c) SDRs; Region: SDR_c; cd05233 858619005703 NAD(P) binding site [chemical binding]; other site 858619005704 active site 858619005705 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 858619005706 E-class dimer interface [polypeptide binding]; other site 858619005707 P-class dimer interface [polypeptide binding]; other site 858619005708 active site 858619005709 Cu2+ binding site [ion binding]; other site 858619005710 Zn2+ binding site [ion binding]; other site 858619005711 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 858619005712 YCII-related domain; Region: YCII; cl00999 858619005713 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 858619005714 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 858619005715 active site 858619005716 metal binding site [ion binding]; metal-binding site 858619005717 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619005718 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 858619005719 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619005720 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619005721 intersubunit interface [polypeptide binding]; other site 858619005722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 858619005723 MarR family; Region: MarR; pfam01047 858619005724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619005725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005726 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 858619005727 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 858619005728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005729 putative substrate translocation pore; other site 858619005730 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 858619005731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005732 putative substrate translocation pore; other site 858619005733 classical (c) SDRs; Region: SDR_c; cd05233 858619005734 short chain dehydrogenase; Provisional; Region: PRK06523 858619005735 NAD(P) binding site [chemical binding]; other site 858619005736 active site 858619005737 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 858619005738 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619005739 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 858619005740 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619005741 Fic family protein [Function unknown]; Region: COG3177 858619005742 Fic/DOC family; Region: Fic; pfam02661 858619005743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619005744 salt bridge; other site 858619005745 non-specific DNA binding site [nucleotide binding]; other site 858619005746 sequence-specific DNA binding site [nucleotide binding]; other site 858619005747 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 858619005748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005749 Predicted transcriptional regulators [Transcription]; Region: COG1733 858619005750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619005751 dimerization interface [polypeptide binding]; other site 858619005752 putative DNA binding site [nucleotide binding]; other site 858619005753 putative Zn2+ binding site [ion binding]; other site 858619005754 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 858619005755 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 858619005756 putative NAD(P) binding site [chemical binding]; other site 858619005757 dimer interface [polypeptide binding]; other site 858619005758 Methyltransferase domain; Region: Methyltransf_23; pfam13489 858619005759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619005760 S-adenosylmethionine binding site [chemical binding]; other site 858619005761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 858619005762 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 858619005763 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 858619005764 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 858619005765 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 858619005766 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 858619005767 putative active site [active] 858619005768 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 858619005769 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 858619005770 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 858619005771 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 858619005772 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 858619005773 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 858619005774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 858619005775 DNA binding site [nucleotide binding] 858619005776 active site 858619005777 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 858619005778 homodimer interface [polypeptide binding]; other site 858619005779 substrate binding pocket [chemical binding]; other site 858619005780 catalytic residues [active] 858619005781 NADH/NADPH cofactor binding site [chemical binding]; other site 858619005782 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 858619005783 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 858619005784 dimer interface [polypeptide binding]; other site 858619005785 active site 858619005786 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 858619005787 active site 2 [active] 858619005788 active site 1 [active] 858619005789 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 858619005790 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 858619005791 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 858619005792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005793 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 858619005794 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 858619005795 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619005796 catalytic core [active] 858619005797 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 858619005798 conserved hypothetical protein; Region: TIGR03843 858619005799 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 858619005800 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 858619005801 Predicted membrane protein [Function unknown]; Region: COG1511 858619005802 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 858619005803 Predicted membrane protein [Function unknown]; Region: COG1511 858619005804 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 858619005805 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 858619005806 ThiC-associated domain; Region: ThiC-associated; pfam13667 858619005807 ThiC family; Region: ThiC; pfam01964 858619005808 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 858619005809 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 858619005810 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 858619005811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619005812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619005815 putative substrate translocation pore; other site 858619005816 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619005817 active site 858619005818 exopolyphosphatase; Region: exo_poly_only; TIGR03706 858619005819 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 858619005820 Uncharacterized conserved protein [Function unknown]; Region: COG1507 858619005821 Septum formation initiator; Region: DivIC; pfam04977 858619005822 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 858619005823 enolase; Provisional; Region: eno; PRK00077 858619005824 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 858619005825 dimer interface [polypeptide binding]; other site 858619005826 metal binding site [ion binding]; metal-binding site 858619005827 substrate binding pocket [chemical binding]; other site 858619005828 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 858619005829 N-acetyl-D-glucosamine binding site [chemical binding]; other site 858619005830 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 858619005831 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 858619005832 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 858619005833 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 858619005834 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 858619005835 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 858619005836 metal binding site [ion binding]; metal-binding site 858619005837 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 858619005838 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 858619005839 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 858619005840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619005841 ABC-ATPase subunit interface; other site 858619005842 dimer interface [polypeptide binding]; other site 858619005843 putative PBP binding regions; other site 858619005844 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 858619005845 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 858619005846 homodimer interface [polypeptide binding]; other site 858619005847 metal binding site [ion binding]; metal-binding site 858619005848 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 858619005849 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 858619005850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619005851 ATP binding site [chemical binding]; other site 858619005852 putative Mg++ binding site [ion binding]; other site 858619005853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619005854 nucleotide binding region [chemical binding]; other site 858619005855 ATP-binding site [chemical binding]; other site 858619005856 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 858619005857 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 858619005858 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 858619005859 Substrate binding site; other site 858619005860 Mg++ binding site; other site 858619005861 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 858619005862 active site 858619005863 substrate binding site [chemical binding]; other site 858619005864 CoA binding site [chemical binding]; other site 858619005865 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 858619005866 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 858619005867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619005868 active site 858619005869 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 858619005870 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 858619005871 5S rRNA interface [nucleotide binding]; other site 858619005872 CTC domain interface [polypeptide binding]; other site 858619005873 L16 interface [polypeptide binding]; other site 858619005874 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 858619005875 putative active site [active] 858619005876 catalytic residue [active] 858619005877 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 858619005878 putative active site [active] 858619005879 catalytic residue [active] 858619005880 dihydroxyacetone kinase; Provisional; Region: PRK14479 858619005881 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 858619005882 DAK2 domain; Region: Dak2; pfam02734 858619005883 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 858619005884 S-adenosylmethionine binding site [chemical binding]; other site 858619005885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 858619005886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 858619005887 active site 858619005888 catalytic tetrad [active] 858619005889 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 858619005890 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 858619005891 G1 box; other site 858619005892 putative GEF interaction site [polypeptide binding]; other site 858619005893 GTP/Mg2+ binding site [chemical binding]; other site 858619005894 Switch I region; other site 858619005895 G2 box; other site 858619005896 G3 box; other site 858619005897 Switch II region; other site 858619005898 G4 box; other site 858619005899 G5 box; other site 858619005900 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 858619005901 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 858619005902 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 858619005903 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 858619005904 Isochorismatase family; Region: Isochorismatase; pfam00857 858619005905 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 858619005906 catalytic triad [active] 858619005907 conserved cis-peptide bond; other site 858619005908 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 858619005909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619005910 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 858619005911 NAD(P) binding site [chemical binding]; other site 858619005912 active site 858619005913 MMPL family; Region: MMPL; pfam03176 858619005914 MMPL family; Region: MMPL; pfam03176 858619005915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619005916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619005917 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 858619005918 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 858619005919 active site 858619005920 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 858619005921 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619005922 substrate binding site [chemical binding]; other site 858619005923 oxyanion hole (OAH) forming residues; other site 858619005924 trimer interface [polypeptide binding]; other site 858619005925 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 858619005926 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 858619005927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619005928 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 858619005929 acyl-activating enzyme (AAE) consensus motif; other site 858619005930 putative AMP binding site [chemical binding]; other site 858619005931 putative active site [active] 858619005932 putative CoA binding site [chemical binding]; other site 858619005933 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 858619005934 Domain of unknown function (DUF222); Region: DUF222; pfam02720 858619005935 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 858619005936 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 858619005937 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 858619005938 Transcriptional regulator [Transcription]; Region: IclR; COG1414 858619005939 Bacterial transcriptional regulator; Region: IclR; pfam01614 858619005940 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 858619005941 hydroxyglutarate oxidase; Provisional; Region: PRK11728 858619005942 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 858619005943 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 858619005944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619005945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619005946 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 858619005947 putative dimerization interface [polypeptide binding]; other site 858619005948 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 858619005949 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 858619005950 iron-sulfur cluster [ion binding]; other site 858619005951 [2Fe-2S] cluster binding site [ion binding]; other site 858619005952 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 858619005953 putative alpha subunit interface [polypeptide binding]; other site 858619005954 putative active site [active] 858619005955 putative substrate binding site [chemical binding]; other site 858619005956 Fe binding site [ion binding]; other site 858619005957 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 858619005958 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 858619005959 FAD binding pocket [chemical binding]; other site 858619005960 conserved FAD binding motif [chemical binding]; other site 858619005961 phosphate binding motif [ion binding]; other site 858619005962 beta-alpha-beta structure motif; other site 858619005963 NAD binding pocket [chemical binding]; other site 858619005964 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 858619005965 catalytic loop [active] 858619005966 iron binding site [ion binding]; other site 858619005967 Uncharacterized conserved protein [Function unknown]; Region: COG1359 858619005968 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 858619005969 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 858619005970 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 858619005971 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 858619005972 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 858619005973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619005974 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 858619005975 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 858619005976 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 858619005977 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 858619005978 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 858619005979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 858619005980 Domain of unknown function (DUF348); Region: DUF348; pfam03990 858619005981 Domain of unknown function (DUF348); Region: DUF348; pfam03990 858619005982 Domain of unknown function (DUF348); Region: DUF348; pfam03990 858619005983 G5 domain; Region: G5; pfam07501 858619005984 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 858619005985 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 858619005986 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 858619005987 active site 858619005988 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 858619005989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619005990 putative substrate translocation pore; other site 858619005991 Winged helix-turn helix; Region: HTH_29; pfam13551 858619005992 Homeodomain-like domain; Region: HTH_23; cl17451 858619005993 Integrase core domain; Region: rve; pfam00665 858619005994 Integrase core domain; Region: rve_3; pfam13683 858619005995 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 858619005996 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 858619005997 active site 858619005998 HIGH motif; other site 858619005999 KMSKS motif; other site 858619006000 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 858619006001 tRNA binding surface [nucleotide binding]; other site 858619006002 anticodon binding site; other site 858619006003 potential frameshift: common BLAST hit: gi|237785126|ref|YP_002905831.1| Choline-glycine betaine transporter 858619006004 BCCT family transporter; Region: BCCT; cl00569 858619006005 BCCT family transporter; Region: BCCT; pfam02028 858619006006 Predicted methyltransferases [General function prediction only]; Region: COG0313 858619006007 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 858619006008 putative SAM binding site [chemical binding]; other site 858619006009 putative homodimer interface [polypeptide binding]; other site 858619006010 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 858619006011 Predicted integral membrane protein [Function unknown]; Region: COG5660 858619006012 Putative zinc-finger; Region: zf-HC2; pfam13490 858619006013 Predicted membrane protein [Function unknown]; Region: COG2259 858619006014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 858619006015 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 858619006016 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 858619006017 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 858619006018 dimer interface [polypeptide binding]; other site 858619006019 putative functional site; other site 858619006020 putative MPT binding site; other site 858619006021 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 858619006022 active site 858619006023 tetramer interface; other site 858619006024 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 858619006025 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 858619006026 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 858619006027 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 858619006028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 858619006029 MPT binding site; other site 858619006030 trimer interface [polypeptide binding]; other site 858619006031 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 858619006032 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 858619006033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 858619006034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619006035 active site 858619006036 phosphorylation site [posttranslational modification] 858619006037 intermolecular recognition site; other site 858619006038 dimerization interface [polypeptide binding]; other site 858619006039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 858619006040 DNA binding site [nucleotide binding] 858619006041 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 858619006042 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 858619006043 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 858619006044 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 858619006045 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 858619006046 30S ribosomal protein S18; Provisional; Region: PRK13401 858619006047 RDD family; Region: RDD; pfam06271 858619006048 RDD family; Region: RDD; pfam06271 858619006049 RDD family; Region: RDD; pfam06271 858619006050 Predicted permeases [General function prediction only]; Region: COG0679 858619006051 TM2 domain; Region: TM2; cl00984 858619006052 putative acyltransferase; Provisional; Region: PRK05790 858619006053 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 858619006054 dimer interface [polypeptide binding]; other site 858619006055 active site 858619006056 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 858619006057 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 858619006058 AMP-binding domain protein; Validated; Region: PRK08315 858619006059 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619006060 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 858619006061 acyl-activating enzyme (AAE) consensus motif; other site 858619006062 acyl-activating enzyme (AAE) consensus motif; other site 858619006063 putative AMP binding site [chemical binding]; other site 858619006064 putative active site [active] 858619006065 putative CoA binding site [chemical binding]; other site 858619006066 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 858619006067 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 858619006068 putative active site [active] 858619006069 putative catalytic site [active] 858619006070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619006071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619006072 active site 858619006073 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 858619006074 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619006075 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 858619006076 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 858619006077 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 858619006078 carboxyltransferase (CT) interaction site; other site 858619006079 biotinylation site [posttranslational modification]; other site 858619006080 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 858619006081 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 858619006082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619006083 active site 858619006084 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 858619006085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619006086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619006087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619006088 active site 858619006089 RNA polymerase factor sigma-70; Validated; Region: PRK08241 858619006090 SnoaL-like domain; Region: SnoaL_2; pfam12680 858619006091 RibD C-terminal domain; Region: RibD_C; cl17279 858619006092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619006093 GXWXG protein; Region: GXWXG; pfam14231 858619006094 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 858619006095 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 858619006096 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 858619006097 dimer interface [polypeptide binding]; other site 858619006098 putative catalytic residues [active] 858619006099 purine monophosphate binding site [chemical binding]; other site 858619006100 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 858619006101 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 858619006102 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 858619006103 active site 858619006104 substrate binding site [chemical binding]; other site 858619006105 cosubstrate binding site; other site 858619006106 catalytic site [active] 858619006107 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 858619006108 Peptidase family M23; Region: Peptidase_M23; pfam01551 858619006109 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 858619006110 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 858619006111 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 858619006112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 858619006113 Walker A/P-loop; other site 858619006114 ATP binding site [chemical binding]; other site 858619006115 Q-loop/lid; other site 858619006116 ABC transporter signature motif; other site 858619006117 Walker B; other site 858619006118 D-loop; other site 858619006119 H-loop/switch region; other site 858619006120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 858619006121 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 858619006122 Walker A/P-loop; other site 858619006123 ATP binding site [chemical binding]; other site 858619006124 Q-loop/lid; other site 858619006125 ABC transporter signature motif; other site 858619006126 Walker B; other site 858619006127 D-loop; other site 858619006128 H-loop/switch region; other site 858619006129 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 858619006130 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 858619006131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006132 dimer interface [polypeptide binding]; other site 858619006133 conserved gate region; other site 858619006134 putative PBP binding loops; other site 858619006135 ABC-ATPase subunit interface; other site 858619006136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 858619006137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006138 dimer interface [polypeptide binding]; other site 858619006139 conserved gate region; other site 858619006140 putative PBP binding loops; other site 858619006141 ABC-ATPase subunit interface; other site 858619006142 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 858619006143 Part of AAA domain; Region: AAA_19; pfam13245 858619006144 Family description; Region: UvrD_C_2; pfam13538 858619006145 hypothetical protein; Provisional; Region: PRK07857 858619006146 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 858619006147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619006148 DNA-binding site [nucleotide binding]; DNA binding site 858619006149 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 858619006150 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 858619006151 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 858619006152 putative substrate binding site [chemical binding]; other site 858619006153 putative ATP binding site [chemical binding]; other site 858619006154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 858619006155 active site 858619006156 phosphorylation site [posttranslational modification] 858619006157 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 858619006158 active site 858619006159 P-loop; other site 858619006160 phosphorylation site [posttranslational modification] 858619006161 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 858619006162 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 858619006163 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 858619006164 intracellular protease, PfpI family; Region: PfpI; TIGR01382 858619006165 proposed catalytic triad [active] 858619006166 conserved cys residue [active] 858619006167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619006168 NAD(P) binding site [chemical binding]; other site 858619006169 active site 858619006170 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 858619006171 dimer interface [polypeptide binding]; other site 858619006172 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 858619006173 dimer interface [polypeptide binding]; other site 858619006174 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 858619006175 active site 858619006176 Int/Topo IB signature motif; other site 858619006177 catalytic residues [active] 858619006178 DNA binding site [nucleotide binding] 858619006179 Helix-turn-helix domain; Region: HTH_17; pfam12728 858619006180 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 858619006181 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 858619006182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619006183 non-specific DNA binding site [nucleotide binding]; other site 858619006184 salt bridge; other site 858619006185 sequence-specific DNA binding site [nucleotide binding]; other site 858619006186 Uncharacterized conserved protein [Function unknown]; Region: COG4748 858619006187 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 858619006188 hypothetical protein; Validated; Region: PRK00068 858619006189 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 858619006190 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 858619006191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 858619006192 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 858619006193 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 858619006194 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 858619006195 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 858619006196 Protein of unknown function DUF45; Region: DUF45; cl00636 858619006197 SprT-like family; Region: SprT-like; pfam10263 858619006198 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 858619006199 Part of AAA domain; Region: AAA_19; pfam13245 858619006200 Family description; Region: UvrD_C_2; pfam13538 858619006201 HRDC domain; Region: HRDC; pfam00570 858619006202 Ion channel; Region: Ion_trans_2; pfam07885 858619006203 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 858619006204 TrkA-N domain; Region: TrkA_N; pfam02254 858619006205 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 858619006206 Part of AAA domain; Region: AAA_19; pfam13245 858619006207 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 858619006208 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 858619006209 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 858619006210 TIGR02569 family protein; Region: TIGR02569_actnb 858619006211 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 858619006212 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 858619006213 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 858619006214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 858619006215 ATP binding site [chemical binding]; other site 858619006216 Mg++ binding site [ion binding]; other site 858619006217 motif III; other site 858619006218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619006219 nucleotide binding region [chemical binding]; other site 858619006220 ATP-binding site [chemical binding]; other site 858619006221 Transcription factor WhiB; Region: Whib; pfam02467 858619006222 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 858619006223 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 858619006224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619006225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 858619006226 DNA binding residues [nucleotide binding] 858619006227 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 858619006228 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 858619006229 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 858619006230 hinge; other site 858619006231 active site 858619006232 Predicted GTPases [General function prediction only]; Region: COG1162 858619006233 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 858619006234 GTPase/Zn-binding domain interface [polypeptide binding]; other site 858619006235 GTP/Mg2+ binding site [chemical binding]; other site 858619006236 G4 box; other site 858619006237 G5 box; other site 858619006238 G1 box; other site 858619006239 Switch I region; other site 858619006240 G2 box; other site 858619006241 G3 box; other site 858619006242 Switch II region; other site 858619006243 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 858619006244 metal binding site 2 [ion binding]; metal-binding site 858619006245 putative DNA binding helix; other site 858619006246 metal binding site 1 [ion binding]; metal-binding site 858619006247 dimer interface [polypeptide binding]; other site 858619006248 structural Zn2+ binding site [ion binding]; other site 858619006249 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 858619006250 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 858619006251 heme binding site [chemical binding]; other site 858619006252 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 858619006253 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 858619006254 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 858619006255 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 858619006256 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 858619006257 30S subunit binding site; other site 858619006258 lipoprotein LpqB; Provisional; Region: PRK13616 858619006259 Sporulation and spore germination; Region: Germane; pfam10646 858619006260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 858619006261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 858619006262 dimerization interface [polypeptide binding]; other site 858619006263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 858619006264 dimer interface [polypeptide binding]; other site 858619006265 phosphorylation site [posttranslational modification] 858619006266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619006267 ATP binding site [chemical binding]; other site 858619006268 Mg2+ binding site [ion binding]; other site 858619006269 G-X-G motif; other site 858619006270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 858619006271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619006272 active site 858619006273 phosphorylation site [posttranslational modification] 858619006274 intermolecular recognition site; other site 858619006275 dimerization interface [polypeptide binding]; other site 858619006276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 858619006277 DNA binding site [nucleotide binding] 858619006278 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 858619006279 TMP-binding site; other site 858619006280 ATP-binding site [chemical binding]; other site 858619006281 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 858619006282 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 858619006283 homotetramer interface [polypeptide binding]; other site 858619006284 ligand binding site [chemical binding]; other site 858619006285 catalytic site [active] 858619006286 NAD binding site [chemical binding]; other site 858619006287 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 858619006288 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 858619006289 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 858619006290 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 858619006291 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 858619006292 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 858619006293 active site 858619006294 substrate binding site [chemical binding]; other site 858619006295 metal binding site [ion binding]; metal-binding site 858619006296 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 858619006297 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 858619006298 Transcription factor WhiB; Region: Whib; pfam02467 858619006299 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 858619006300 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 858619006301 active site 858619006302 Substrate binding site; other site 858619006303 Mg++ binding site; other site 858619006304 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 858619006305 putative trimer interface [polypeptide binding]; other site 858619006306 putative CoA binding site [chemical binding]; other site 858619006307 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 858619006308 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 858619006309 Probable Catalytic site; other site 858619006310 metal-binding site 858619006311 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 858619006312 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 858619006313 NADP binding site [chemical binding]; other site 858619006314 active site 858619006315 putative substrate binding site [chemical binding]; other site 858619006316 Transcriptional regulator [Transcription]; Region: LytR; COG1316 858619006317 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 858619006318 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 858619006319 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 858619006320 putative substrate binding site [chemical binding]; other site 858619006321 putative ATP binding site [chemical binding]; other site 858619006322 VanZ like family; Region: VanZ; cl01971 858619006323 TIGR03089 family protein; Region: TIGR03089 858619006324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 858619006325 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 858619006326 Walker A/P-loop; other site 858619006327 ATP binding site [chemical binding]; other site 858619006328 Q-loop/lid; other site 858619006329 ABC transporter signature motif; other site 858619006330 Walker B; other site 858619006331 D-loop; other site 858619006332 H-loop/switch region; other site 858619006333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619006334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619006335 active site 858619006336 phosphorylation site [posttranslational modification] 858619006337 intermolecular recognition site; other site 858619006338 dimerization interface [polypeptide binding]; other site 858619006339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619006340 DNA binding residues [nucleotide binding] 858619006341 dimerization interface [polypeptide binding]; other site 858619006342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 858619006343 Histidine kinase; Region: HisKA_3; pfam07730 858619006344 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 858619006345 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 858619006346 Walker A/P-loop; other site 858619006347 ATP binding site [chemical binding]; other site 858619006348 Q-loop/lid; other site 858619006349 ABC transporter signature motif; other site 858619006350 Walker B; other site 858619006351 D-loop; other site 858619006352 H-loop/switch region; other site 858619006353 TOBE domain; Region: TOBE_2; pfam08402 858619006354 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 858619006355 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 858619006356 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 858619006357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006358 dimer interface [polypeptide binding]; other site 858619006359 conserved gate region; other site 858619006360 putative PBP binding loops; other site 858619006361 ABC-ATPase subunit interface; other site 858619006362 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 858619006363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006364 dimer interface [polypeptide binding]; other site 858619006365 conserved gate region; other site 858619006366 putative PBP binding loops; other site 858619006367 ABC-ATPase subunit interface; other site 858619006368 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 858619006369 putative active site [active] 858619006370 AIR carboxylase; Region: AIRC; pfam00731 858619006371 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 858619006372 ATP-grasp domain; Region: ATP-grasp; pfam02222 858619006373 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 858619006374 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 858619006375 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 858619006376 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 858619006377 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 858619006378 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 858619006379 active site 858619006380 dimer interface [polypeptide binding]; other site 858619006381 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 858619006382 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 858619006383 active site residue [active] 858619006384 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 858619006385 active site residue [active] 858619006386 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 858619006387 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619006388 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 858619006389 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 858619006390 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 858619006391 lipoyl-biotinyl attachment site [posttranslational modification]; other site 858619006392 glycerol kinase; Provisional; Region: glpK; PRK00047 858619006393 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 858619006394 nucleotide binding site [chemical binding]; other site 858619006395 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 858619006396 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 858619006397 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 858619006398 metal binding site [ion binding]; metal-binding site 858619006399 putative dimer interface [polypeptide binding]; other site 858619006400 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 858619006401 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 858619006402 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 858619006403 active site 858619006404 substrate binding site [chemical binding]; other site 858619006405 metal binding site [ion binding]; metal-binding site 858619006406 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 858619006407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619006408 active site 858619006409 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 858619006410 NlpC/P60 family; Region: NLPC_P60; pfam00877 858619006411 Predicted membrane protein [Function unknown]; Region: COG1289 858619006412 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 858619006413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 858619006414 Catalytic domain of Protein Kinases; Region: PKc; cd00180 858619006415 active site 858619006416 ATP binding site [chemical binding]; other site 858619006417 substrate binding site [chemical binding]; other site 858619006418 activation loop (A-loop); other site 858619006419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 858619006420 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 858619006421 Walker A/P-loop; other site 858619006422 ATP binding site [chemical binding]; other site 858619006423 Q-loop/lid; other site 858619006424 ABC transporter signature motif; other site 858619006425 Walker B; other site 858619006426 D-loop; other site 858619006427 H-loop/switch region; other site 858619006428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 858619006429 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 858619006430 TM-ABC transporter signature motif; other site 858619006431 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 858619006432 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 858619006433 putative ligand binding site [chemical binding]; other site 858619006434 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 858619006435 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 858619006436 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 858619006437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619006438 DNA-binding site [nucleotide binding]; DNA binding site 858619006439 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619006440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619006441 homodimer interface [polypeptide binding]; other site 858619006442 catalytic residue [active] 858619006443 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619006444 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619006445 intersubunit interface [polypeptide binding]; other site 858619006446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619006447 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 858619006448 Walker A/P-loop; other site 858619006449 ATP binding site [chemical binding]; other site 858619006450 Q-loop/lid; other site 858619006451 ABC transporter signature motif; other site 858619006452 Walker B; other site 858619006453 D-loop; other site 858619006454 H-loop/switch region; other site 858619006455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619006456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619006457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619006458 Walker A/P-loop; other site 858619006459 ATP binding site [chemical binding]; other site 858619006460 Q-loop/lid; other site 858619006461 ABC transporter signature motif; other site 858619006462 Walker B; other site 858619006463 D-loop; other site 858619006464 H-loop/switch region; other site 858619006465 adenosine deaminase; Provisional; Region: PRK09358 858619006466 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 858619006467 active site 858619006468 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 858619006469 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 858619006470 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 858619006471 Predicted oxidoreductase [General function prediction only]; Region: COG3573 858619006472 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 858619006473 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 858619006474 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 858619006475 active site 858619006476 metal binding site [ion binding]; metal-binding site 858619006477 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 858619006478 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 858619006479 active site 858619006480 HIGH motif; other site 858619006481 dimer interface [polypeptide binding]; other site 858619006482 KMSKS motif; other site 858619006483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619006484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619006485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 858619006486 dimerization interface [polypeptide binding]; other site 858619006487 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 858619006488 gating phenylalanine in ion channel; other site 858619006489 short chain dehydrogenase; Provisional; Region: PRK08278 858619006490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619006491 NAD(P) binding site [chemical binding]; other site 858619006492 active site 858619006493 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 858619006494 putative catalytic site [active] 858619006495 putative metal binding site [ion binding]; other site 858619006496 putative phosphate binding site [ion binding]; other site 858619006497 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 858619006498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619006499 putative substrate translocation pore; other site 858619006500 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 858619006501 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 858619006502 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 858619006503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 858619006504 homodimer interface [polypeptide binding]; other site 858619006505 substrate-cofactor binding pocket; other site 858619006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619006507 catalytic residue [active] 858619006508 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 858619006509 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 858619006510 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 858619006511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619006512 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 858619006513 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 858619006514 Walker A/P-loop; other site 858619006515 ATP binding site [chemical binding]; other site 858619006516 Q-loop/lid; other site 858619006517 ABC transporter signature motif; other site 858619006518 Walker B; other site 858619006519 D-loop; other site 858619006520 H-loop/switch region; other site 858619006521 sulfate transport protein; Provisional; Region: cysT; CHL00187 858619006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006523 dimer interface [polypeptide binding]; other site 858619006524 conserved gate region; other site 858619006525 putative PBP binding loops; other site 858619006526 ABC-ATPase subunit interface; other site 858619006527 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 858619006528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006529 dimer interface [polypeptide binding]; other site 858619006530 conserved gate region; other site 858619006531 putative PBP binding loops; other site 858619006532 ABC-ATPase subunit interface; other site 858619006533 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 858619006534 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 858619006535 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619006536 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 858619006537 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 858619006538 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 858619006539 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 858619006540 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 858619006541 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 858619006542 homodimer interface [polypeptide binding]; other site 858619006543 NADP binding site [chemical binding]; other site 858619006544 substrate binding site [chemical binding]; other site 858619006545 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 858619006546 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 858619006547 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 858619006548 active site 858619006549 metal binding site [ion binding]; metal-binding site 858619006550 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 858619006551 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 858619006552 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 858619006553 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 858619006554 trimer interface [polypeptide binding]; other site 858619006555 active site 858619006556 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 858619006557 trimer interface [polypeptide binding]; other site 858619006558 active site 858619006559 G bulge; other site 858619006560 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 858619006561 Secretory lipase; Region: LIP; pfam03583 858619006562 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 858619006563 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 858619006564 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 858619006565 active site 858619006566 PHP Thumb interface [polypeptide binding]; other site 858619006567 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 858619006568 generic binding surface II; other site 858619006569 generic binding surface I; other site 858619006570 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 858619006571 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 858619006572 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 858619006573 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 858619006574 Walker A/P-loop; other site 858619006575 ATP binding site [chemical binding]; other site 858619006576 Q-loop/lid; other site 858619006577 ABC transporter signature motif; other site 858619006578 Walker B; other site 858619006579 D-loop; other site 858619006580 H-loop/switch region; other site 858619006581 NIL domain; Region: NIL; pfam09383 858619006582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006583 dimer interface [polypeptide binding]; other site 858619006584 conserved gate region; other site 858619006585 putative PBP binding loops; other site 858619006586 ABC-ATPase subunit interface; other site 858619006587 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 858619006588 putative dimer interface [polypeptide binding]; other site 858619006589 putative [2Fe-2S] cluster binding site [ion binding]; other site 858619006590 DNA Polymerase Y-family; Region: PolY_like; cd03468 858619006591 active site 858619006592 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 858619006593 GMP synthase; Reviewed; Region: guaA; PRK00074 858619006594 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 858619006595 AMP/PPi binding site [chemical binding]; other site 858619006596 candidate oxyanion hole; other site 858619006597 catalytic triad [active] 858619006598 potential glutamine specificity residues [chemical binding]; other site 858619006599 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 858619006600 ATP Binding subdomain [chemical binding]; other site 858619006601 Ligand Binding sites [chemical binding]; other site 858619006602 Dimerization subdomain; other site 858619006603 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 858619006604 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 858619006605 phosphate binding site [ion binding]; other site 858619006606 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 858619006607 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 858619006608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 858619006609 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 858619006610 active site 858619006611 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 858619006612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619006613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 858619006614 DNA binding residues [nucleotide binding] 858619006615 Transcription factor WhiB; Region: Whib; pfam02467 858619006616 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 858619006617 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 858619006618 ring oligomerisation interface [polypeptide binding]; other site 858619006619 ATP/Mg binding site [chemical binding]; other site 858619006620 stacking interactions; other site 858619006621 hinge regions; other site 858619006622 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 858619006623 oligomerisation interface [polypeptide binding]; other site 858619006624 mobile loop; other site 858619006625 roof hairpin; other site 858619006626 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 858619006627 Glycoprotease family; Region: Peptidase_M22; pfam00814 858619006628 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 858619006629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 858619006630 Coenzyme A binding pocket [chemical binding]; other site 858619006631 UGMP family protein; Validated; Region: PRK09604 858619006632 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 858619006633 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 858619006634 glutaminase active site [active] 858619006635 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 858619006636 dimer interface [polypeptide binding]; other site 858619006637 active site 858619006638 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 858619006639 dimer interface [polypeptide binding]; other site 858619006640 active site 858619006641 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 858619006642 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 858619006643 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 858619006644 active site 858619006645 substrate binding site [chemical binding]; other site 858619006646 metal binding site [ion binding]; metal-binding site 858619006647 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 858619006648 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 858619006649 23S rRNA interface [nucleotide binding]; other site 858619006650 L3 interface [polypeptide binding]; other site 858619006651 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 858619006652 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 858619006653 Transcriptional regulators [Transcription]; Region: FadR; COG2186 858619006654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619006655 DNA-binding site [nucleotide binding]; DNA binding site 858619006656 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 858619006657 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 858619006658 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 858619006659 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 858619006660 AAA domain; Region: AAA_25; pfam13481 858619006661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619006662 Walker A motif; other site 858619006663 ATP binding site [chemical binding]; other site 858619006664 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619006665 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 858619006666 catalytic residues [active] 858619006667 catalytic nucleophile [active] 858619006668 Recombinase; Region: Recombinase; pfam07508 858619006669 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 858619006670 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 858619006671 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 858619006672 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 858619006673 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 858619006674 active site 858619006675 catalytic residues [active] 858619006676 Protein of unknown function (DUF690); Region: DUF690; cl04939 858619006677 Sodium Bile acid symporter family; Region: SBF; cl17470 858619006678 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 858619006679 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 858619006680 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 858619006681 dimerization interface 3.5A [polypeptide binding]; other site 858619006682 active site 858619006683 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 858619006684 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 858619006685 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 858619006686 alphaNTD - beta interaction site [polypeptide binding]; other site 858619006687 alphaNTD homodimer interface [polypeptide binding]; other site 858619006688 alphaNTD - beta' interaction site [polypeptide binding]; other site 858619006689 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 858619006690 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 858619006691 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 858619006692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 858619006693 RNA binding surface [nucleotide binding]; other site 858619006694 30S ribosomal protein S11; Validated; Region: PRK05309 858619006695 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 858619006696 30S ribosomal protein S13; Region: bact_S13; TIGR03631 858619006697 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 858619006698 rRNA binding site [nucleotide binding]; other site 858619006699 predicted 30S ribosome binding site; other site 858619006700 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 858619006701 active site 858619006702 adenylate kinase; Reviewed; Region: adk; PRK00279 858619006703 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 858619006704 AMP-binding site [chemical binding]; other site 858619006705 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 858619006706 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 858619006707 SecY translocase; Region: SecY; pfam00344 858619006708 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 858619006709 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 858619006710 23S rRNA binding site [nucleotide binding]; other site 858619006711 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 858619006712 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 858619006713 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 858619006714 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 858619006715 5S rRNA interface [nucleotide binding]; other site 858619006716 L27 interface [polypeptide binding]; other site 858619006717 23S rRNA interface [nucleotide binding]; other site 858619006718 L5 interface [polypeptide binding]; other site 858619006719 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 858619006720 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 858619006721 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 858619006722 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 858619006723 amidophosphoribosyltransferase; Provisional; Region: PRK09246 858619006724 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 858619006725 active site 858619006726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 858619006727 active site 858619006728 nucleosidase; Provisional; Region: PRK05634 858619006729 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 858619006730 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 858619006731 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619006732 intersubunit interface [polypeptide binding]; other site 858619006733 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 858619006734 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 858619006735 putative molybdopterin cofactor binding site [chemical binding]; other site 858619006736 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 858619006737 putative molybdopterin cofactor binding site; other site 858619006738 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 858619006739 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 858619006740 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 858619006741 ATP binding site [chemical binding]; other site 858619006742 substrate interface [chemical binding]; other site 858619006743 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 858619006744 active site residue [active] 858619006745 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 858619006746 MoaE homodimer interface [polypeptide binding]; other site 858619006747 MoaD interaction [polypeptide binding]; other site 858619006748 active site residues [active] 858619006749 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 858619006750 MPT binding site; other site 858619006751 trimer interface [polypeptide binding]; other site 858619006752 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 858619006753 trimer interface [polypeptide binding]; other site 858619006754 dimer interface [polypeptide binding]; other site 858619006755 putative active site [active] 858619006756 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 858619006757 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 858619006758 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 858619006759 dimer interface [polypeptide binding]; other site 858619006760 putative functional site; other site 858619006761 putative MPT binding site; other site 858619006762 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 858619006763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619006764 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 858619006765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 858619006766 dimerization interface [polypeptide binding]; other site 858619006767 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 858619006768 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 858619006769 dimer interface [polypeptide binding]; other site 858619006770 putative functional site; other site 858619006771 putative MPT binding site; other site 858619006772 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 858619006773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619006774 dimer interface [polypeptide binding]; other site 858619006775 conserved gate region; other site 858619006776 putative PBP binding loops; other site 858619006777 ABC-ATPase subunit interface; other site 858619006778 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 858619006779 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 858619006780 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 858619006781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 858619006782 FeS/SAM binding site; other site 858619006783 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 858619006784 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 858619006785 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 858619006786 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 858619006787 [4Fe-4S] binding site [ion binding]; other site 858619006788 molybdopterin cofactor binding site; other site 858619006789 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 858619006790 molybdopterin cofactor binding site; other site 858619006791 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 858619006792 Flavodoxin; Region: Flavodoxin_1; pfam00258 858619006793 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 858619006794 FAD binding pocket [chemical binding]; other site 858619006795 conserved FAD binding motif [chemical binding]; other site 858619006796 phosphate binding motif [ion binding]; other site 858619006797 beta-alpha-beta structure motif; other site 858619006798 NAD binding pocket [chemical binding]; other site 858619006799 nitrite reductase subunit NirD; Provisional; Region: PRK14989 858619006800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619006801 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 858619006802 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 858619006803 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 858619006804 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 858619006805 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 858619006806 homodimer interface [polypeptide binding]; other site 858619006807 active site 858619006808 SAM binding site [chemical binding]; other site 858619006809 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 858619006810 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 858619006811 active site 858619006812 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 858619006813 DNA binding site [nucleotide binding] 858619006814 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 858619006815 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 858619006816 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 858619006817 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 858619006818 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 858619006819 RNA binding site [nucleotide binding]; other site 858619006820 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 858619006821 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619006822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619006823 ABC-ATPase subunit interface; other site 858619006824 dimer interface [polypeptide binding]; other site 858619006825 putative PBP binding regions; other site 858619006826 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 858619006827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619006828 ABC-ATPase subunit interface; other site 858619006829 dimer interface [polypeptide binding]; other site 858619006830 putative PBP binding regions; other site 858619006831 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619006832 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619006833 Walker A/P-loop; other site 858619006834 ATP binding site [chemical binding]; other site 858619006835 Q-loop/lid; other site 858619006836 ABC transporter signature motif; other site 858619006837 Walker B; other site 858619006838 D-loop; other site 858619006839 H-loop/switch region; other site 858619006840 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619006841 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619006842 FAD binding pocket [chemical binding]; other site 858619006843 FAD binding motif [chemical binding]; other site 858619006844 phosphate binding motif [ion binding]; other site 858619006845 NAD binding pocket [chemical binding]; other site 858619006846 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 858619006847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619006848 putative substrate translocation pore; other site 858619006849 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 858619006850 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 858619006851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619006852 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619006853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619006854 AMP-binding enzyme; Region: AMP-binding; pfam00501 858619006855 acyl-activating enzyme (AAE) consensus motif; other site 858619006856 AMP binding site [chemical binding]; other site 858619006857 active site 858619006858 CoA binding site [chemical binding]; other site 858619006859 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 858619006860 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 858619006861 putative translocon interaction site; other site 858619006862 23S rRNA interface [nucleotide binding]; other site 858619006863 signal recognition particle (SRP54) interaction site; other site 858619006864 L23 interface [polypeptide binding]; other site 858619006865 trigger factor interaction site; other site 858619006866 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 858619006867 23S rRNA interface [nucleotide binding]; other site 858619006868 5S rRNA interface [nucleotide binding]; other site 858619006869 putative antibiotic binding site [chemical binding]; other site 858619006870 L25 interface [polypeptide binding]; other site 858619006871 L27 interface [polypeptide binding]; other site 858619006872 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 858619006873 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 858619006874 G-X-X-G motif; other site 858619006875 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 858619006876 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 858619006877 putative translocon binding site; other site 858619006878 protein-rRNA interface [nucleotide binding]; other site 858619006879 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 858619006880 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 858619006881 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 858619006882 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 858619006883 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 858619006884 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 858619006885 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 858619006886 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 858619006887 Asp23 family; Region: Asp23; pfam03780 858619006888 Asp23 family; Region: Asp23; pfam03780 858619006889 elongation factor Tu; Reviewed; Region: PRK00049 858619006890 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 858619006891 G1 box; other site 858619006892 GEF interaction site [polypeptide binding]; other site 858619006893 GTP/Mg2+ binding site [chemical binding]; other site 858619006894 Switch I region; other site 858619006895 G2 box; other site 858619006896 G3 box; other site 858619006897 Switch II region; other site 858619006898 G4 box; other site 858619006899 G5 box; other site 858619006900 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 858619006901 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 858619006902 Antibiotic Binding Site [chemical binding]; other site 858619006903 elongation factor G; Reviewed; Region: PRK00007 858619006904 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 858619006905 G1 box; other site 858619006906 putative GEF interaction site [polypeptide binding]; other site 858619006907 GTP/Mg2+ binding site [chemical binding]; other site 858619006908 Switch I region; other site 858619006909 G2 box; other site 858619006910 G3 box; other site 858619006911 Switch II region; other site 858619006912 G4 box; other site 858619006913 G5 box; other site 858619006914 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 858619006915 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 858619006916 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 858619006917 30S ribosomal protein S7; Validated; Region: PRK05302 858619006918 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 858619006919 S17 interaction site [polypeptide binding]; other site 858619006920 S8 interaction site; other site 858619006921 16S rRNA interaction site [nucleotide binding]; other site 858619006922 streptomycin interaction site [chemical binding]; other site 858619006923 23S rRNA interaction site [nucleotide binding]; other site 858619006924 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 858619006925 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 858619006926 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 858619006927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619006928 catalytic residue [active] 858619006929 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 858619006930 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 858619006931 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 858619006932 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 858619006933 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 858619006934 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 858619006935 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 858619006936 G-loop; other site 858619006937 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 858619006938 DNA binding site [nucleotide binding] 858619006939 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 858619006940 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 858619006941 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 858619006942 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 858619006943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 858619006944 RPB1 interaction site [polypeptide binding]; other site 858619006945 RPB10 interaction site [polypeptide binding]; other site 858619006946 RPB11 interaction site [polypeptide binding]; other site 858619006947 RPB3 interaction site [polypeptide binding]; other site 858619006948 RPB12 interaction site [polypeptide binding]; other site 858619006949 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 858619006950 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 858619006951 peripheral dimer interface [polypeptide binding]; other site 858619006952 core dimer interface [polypeptide binding]; other site 858619006953 L10 interface [polypeptide binding]; other site 858619006954 L11 interface [polypeptide binding]; other site 858619006955 putative EF-Tu interaction site [polypeptide binding]; other site 858619006956 putative EF-G interaction site [polypeptide binding]; other site 858619006957 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 858619006958 23S rRNA interface [nucleotide binding]; other site 858619006959 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 858619006960 Lipase (class 2); Region: Lipase_2; pfam01674 858619006961 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 858619006962 mRNA/rRNA interface [nucleotide binding]; other site 858619006963 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 858619006964 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 858619006965 23S rRNA interface [nucleotide binding]; other site 858619006966 L7/L12 interface [polypeptide binding]; other site 858619006967 putative thiostrepton binding site; other site 858619006968 L25 interface [polypeptide binding]; other site 858619006969 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 858619006970 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 858619006971 putative homodimer interface [polypeptide binding]; other site 858619006972 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 858619006973 heterodimer interface [polypeptide binding]; other site 858619006974 homodimer interface [polypeptide binding]; other site 858619006975 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 858619006976 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 858619006977 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 858619006978 substrate binding pocket [chemical binding]; other site 858619006979 chain length determination region; other site 858619006980 substrate-Mg2+ binding site; other site 858619006981 catalytic residues [active] 858619006982 aspartate-rich region 1; other site 858619006983 active site lid residues [active] 858619006984 aspartate-rich region 2; other site 858619006985 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 858619006986 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 858619006987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619006988 S-adenosylmethionine binding site [chemical binding]; other site 858619006989 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 858619006990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 858619006991 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 858619006992 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 858619006993 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 858619006994 dimer interface [polypeptide binding]; other site 858619006995 tetramer interface [polypeptide binding]; other site 858619006996 PYR/PP interface [polypeptide binding]; other site 858619006997 TPP binding site [chemical binding]; other site 858619006998 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 858619006999 TPP-binding site; other site 858619007000 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 858619007001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619007002 ABC transporter signature motif; other site 858619007003 Walker B; other site 858619007004 D-loop; other site 858619007005 H-loop/switch region; other site 858619007006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619007007 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619007008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619007009 Transposase [DNA replication, recombination, and repair]; Region: COG5421 858619007010 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 858619007011 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 858619007012 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 858619007013 metal-binding site [ion binding] 858619007014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619007015 Soluble P-type ATPase [General function prediction only]; Region: COG4087 858619007016 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 858619007017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619007018 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619007019 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 858619007020 metal-binding site [ion binding] 858619007021 DJ-1 family protein; Region: not_thiJ; TIGR01383 858619007022 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 858619007023 conserved cys residue [active] 858619007024 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 858619007025 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619007026 intersubunit interface [polypeptide binding]; other site 858619007027 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619007028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619007029 ABC-ATPase subunit interface; other site 858619007030 dimer interface [polypeptide binding]; other site 858619007031 putative PBP binding regions; other site 858619007032 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619007033 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619007034 Walker A/P-loop; other site 858619007035 ATP binding site [chemical binding]; other site 858619007036 Q-loop/lid; other site 858619007037 ABC transporter signature motif; other site 858619007038 Walker B; other site 858619007039 D-loop; other site 858619007040 H-loop/switch region; other site 858619007041 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619007042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619007043 ABC transporter signature motif; other site 858619007044 Walker B; other site 858619007045 D-loop; other site 858619007046 H-loop/switch region; other site 858619007047 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 858619007048 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 858619007049 Presynaptic Site I dimer interface [polypeptide binding]; other site 858619007050 catalytic residues [active] 858619007051 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 858619007052 Synaptic Flat tetramer interface [polypeptide binding]; other site 858619007053 Synaptic Site I dimer interface [polypeptide binding]; other site 858619007054 DNA binding site [nucleotide binding] 858619007055 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619007056 DNA-binding interface [nucleotide binding]; DNA binding site 858619007057 Homeodomain-like domain; Region: HTH_23; cl17451 858619007058 Winged helix-turn helix; Region: HTH_29; pfam13551 858619007059 Integrase core domain; Region: rve; pfam00665 858619007060 Integrase core domain; Region: rve_3; pfam13683 858619007061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619007062 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619007063 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 858619007064 DNA polymerase III subunit delta'; Validated; Region: PRK07940 858619007065 DNA polymerase III subunit delta'; Validated; Region: PRK08485 858619007066 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 858619007067 dimerization interface [polypeptide binding]; other site 858619007068 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 858619007069 cyclase homology domain; Region: CHD; cd07302 858619007070 nucleotidyl binding site; other site 858619007071 dimer interface [polypeptide binding]; other site 858619007072 metal binding site [ion binding]; metal-binding site 858619007073 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 858619007074 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 858619007075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619007076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619007077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619007078 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 858619007079 DNA-binding interface [nucleotide binding]; DNA binding site 858619007080 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 858619007081 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 858619007082 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 858619007083 active site 858619007084 PhoD-like phosphatase; Region: PhoD; pfam09423 858619007085 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 858619007086 putative active site [active] 858619007087 putative metal binding site [ion binding]; other site 858619007088 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 858619007089 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 858619007090 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 858619007091 active site 858619007092 interdomain interaction site; other site 858619007093 putative metal-binding site [ion binding]; other site 858619007094 nucleotide binding site [chemical binding]; other site 858619007095 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 858619007096 domain I; other site 858619007097 phosphate binding site [ion binding]; other site 858619007098 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 858619007099 domain II; other site 858619007100 domain III; other site 858619007101 nucleotide binding site [chemical binding]; other site 858619007102 DNA binding groove [nucleotide binding] 858619007103 catalytic site [active] 858619007104 domain IV; other site 858619007105 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 858619007106 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 858619007107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619007108 NADH(P)-binding; Region: NAD_binding_10; pfam13460 858619007109 NAD(P) binding site [chemical binding]; other site 858619007110 active site 858619007111 Predicted transcriptional regulators [Transcription]; Region: COG1733 858619007112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619007113 dimerization interface [polypeptide binding]; other site 858619007114 putative DNA binding site [nucleotide binding]; other site 858619007115 putative Zn2+ binding site [ion binding]; other site 858619007116 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 858619007117 DNA-binding site [nucleotide binding]; DNA binding site 858619007118 RNA-binding motif; other site 858619007119 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 858619007120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619007121 ATP binding site [chemical binding]; other site 858619007122 putative Mg++ binding site [ion binding]; other site 858619007123 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 858619007124 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 858619007125 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 858619007126 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 858619007127 Walker A motif; other site 858619007128 hexamer interface [polypeptide binding]; other site 858619007129 ATP binding site [chemical binding]; other site 858619007130 Walker B motif; other site 858619007131 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 858619007132 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 858619007133 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 858619007134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 858619007135 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 858619007136 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619007137 MULE transposase domain; Region: MULE; pfam10551 858619007138 Colicin V production protein; Region: Colicin_V; pfam02674 858619007139 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 858619007140 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 858619007141 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 858619007142 putative active site [active] 858619007143 putative CoA binding site [chemical binding]; other site 858619007144 nudix motif; other site 858619007145 metal binding site [ion binding]; metal-binding site 858619007146 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 858619007147 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 858619007148 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 858619007149 catalytic residues [active] 858619007150 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 858619007151 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 858619007152 minor groove reading motif; other site 858619007153 helix-hairpin-helix signature motif; other site 858619007154 substrate binding pocket [chemical binding]; other site 858619007155 active site 858619007156 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 858619007157 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 858619007158 ligand binding site [chemical binding]; other site 858619007159 flexible hinge region; other site 858619007160 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 858619007161 putative switch regulator; other site 858619007162 non-specific DNA interactions [nucleotide binding]; other site 858619007163 DNA binding site [nucleotide binding] 858619007164 sequence specific DNA binding site [nucleotide binding]; other site 858619007165 putative cAMP binding site [chemical binding]; other site 858619007166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619007167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619007168 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 858619007169 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 858619007170 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 858619007171 homotrimer interaction site [polypeptide binding]; other site 858619007172 putative active site [active] 858619007173 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 858619007174 Transcription factor WhiB; Region: Whib; pfam02467 858619007175 Transglycosylase; Region: Transgly; pfam00912 858619007176 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 858619007177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 858619007178 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 858619007179 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 858619007180 putative active site [active] 858619007181 putative metal binding site [ion binding]; other site 858619007182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 858619007183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 858619007184 active site 858619007185 catalytic tetrad [active] 858619007186 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 858619007187 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 858619007188 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 858619007189 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 858619007190 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 858619007191 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 858619007192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 858619007193 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 858619007194 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 858619007195 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 858619007196 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 858619007197 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 858619007198 heme binding pocket [chemical binding]; other site 858619007199 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 858619007200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619007201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 858619007202 DNA binding residues [nucleotide binding] 858619007203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 858619007204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619007205 active site 858619007206 ferrochelatase; Reviewed; Region: hemH; PRK00035 858619007207 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 858619007208 C-terminal domain interface [polypeptide binding]; other site 858619007209 active site 858619007210 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 858619007211 active site 858619007212 N-terminal domain interface [polypeptide binding]; other site 858619007213 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619007214 Ligand Binding Site [chemical binding]; other site 858619007215 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619007216 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619007217 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619007218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619007219 Ligand Binding Site [chemical binding]; other site 858619007220 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 858619007221 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 858619007222 aspartate kinase; Reviewed; Region: PRK06635 858619007223 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 858619007224 putative nucleotide binding site [chemical binding]; other site 858619007225 putative catalytic residues [active] 858619007226 putative Mg ion binding site [ion binding]; other site 858619007227 putative aspartate binding site [chemical binding]; other site 858619007228 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 858619007229 putative allosteric regulatory site; other site 858619007230 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 858619007231 putative allosteric regulatory residue; other site 858619007232 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619007233 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619007234 FAD binding pocket [chemical binding]; other site 858619007235 FAD binding motif [chemical binding]; other site 858619007236 phosphate binding motif [ion binding]; other site 858619007237 NAD binding pocket [chemical binding]; other site 858619007238 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 858619007239 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619007240 intersubunit interface [polypeptide binding]; other site 858619007241 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 858619007242 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619007243 intersubunit interface [polypeptide binding]; other site 858619007244 2-isopropylmalate synthase; Validated; Region: PRK03739 858619007245 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 858619007246 active site 858619007247 catalytic residues [active] 858619007248 metal binding site [ion binding]; metal-binding site 858619007249 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 858619007250 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 858619007251 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 858619007252 tetramer interface [polypeptide binding]; other site 858619007253 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 858619007254 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 858619007255 active site 858619007256 substrate binding site [chemical binding]; other site 858619007257 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 858619007258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 858619007259 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 858619007260 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 858619007261 conserved cys residue [active] 858619007262 potential frameshift: common BLAST hit: gi|33602849|ref|NP_890409.1| high-affinity choline transport protein 858619007263 BCCT family transporter; Region: BCCT; cl00569 858619007264 BCCT family transporter; Region: BCCT; cl00569 858619007265 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 858619007266 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 858619007267 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 858619007268 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 858619007269 phosphate binding site [ion binding]; other site 858619007270 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 858619007271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 858619007272 active site 2 [active] 858619007273 active site 1 [active] 858619007274 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 858619007275 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 858619007276 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 858619007277 putative NAD(P) binding site [chemical binding]; other site 858619007278 active site 858619007279 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 858619007280 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 858619007281 active site 858619007282 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 858619007283 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 858619007284 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 858619007285 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 858619007286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 858619007287 ATP-grasp domain; Region: ATP-grasp_4; cl17255 858619007288 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 858619007289 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 858619007290 carboxyltransferase (CT) interaction site; other site 858619007291 biotinylation site [posttranslational modification]; other site 858619007292 Predicted membrane protein [Function unknown]; Region: COG4270 858619007293 HutD; Region: HutD; cl01532 858619007294 recombination protein RecR; Reviewed; Region: recR; PRK00076 858619007295 RecR protein; Region: RecR; pfam02132 858619007296 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 858619007297 putative active site [active] 858619007298 putative metal-binding site [ion binding]; other site 858619007299 tetramer interface [polypeptide binding]; other site 858619007300 hypothetical protein; Validated; Region: PRK00153 858619007301 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 858619007302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619007303 Walker A motif; other site 858619007304 ATP binding site [chemical binding]; other site 858619007305 Walker B motif; other site 858619007306 arginine finger; other site 858619007307 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 858619007308 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 858619007309 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619007310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619007311 homodimer interface [polypeptide binding]; other site 858619007312 catalytic residue [active] 858619007313 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 858619007314 active site 858619007315 oxyanion hole [active] 858619007316 catalytic triad [active] 858619007317 NAD synthetase; Reviewed; Region: nadE; PRK02628 858619007318 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 858619007319 active site 858619007320 catalytic triad [active] 858619007321 multimer interface [polypeptide binding]; other site 858619007322 protein interface 1 [polypeptide binding]; other site 858619007323 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 858619007324 homodimer interface [polypeptide binding]; other site 858619007325 NAD binding pocket [chemical binding]; other site 858619007326 ATP binding pocket [chemical binding]; other site 858619007327 Mg binding site [ion binding]; other site 858619007328 active-site loop [active] 858619007329 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 858619007330 active site 858619007331 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 858619007332 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 858619007333 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 858619007334 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619007335 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 858619007336 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 858619007337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619007338 intersubunit interface [polypeptide binding]; other site 858619007339 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 858619007340 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619007341 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619007342 Walker A/P-loop; other site 858619007343 ATP binding site [chemical binding]; other site 858619007344 Q-loop/lid; other site 858619007345 ABC transporter signature motif; other site 858619007346 Walker B; other site 858619007347 D-loop; other site 858619007348 H-loop/switch region; other site 858619007349 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619007350 ABC-ATPase subunit interface; other site 858619007351 dimer interface [polypeptide binding]; other site 858619007352 putative PBP binding regions; other site 858619007353 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619007354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619007355 ABC-ATPase subunit interface; other site 858619007356 dimer interface [polypeptide binding]; other site 858619007357 putative PBP binding regions; other site 858619007358 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619007359 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 858619007360 siderophore binding site; other site 858619007361 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 858619007362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619007363 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619007364 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619007365 intersubunit interface [polypeptide binding]; other site 858619007366 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619007367 substrate binding site [chemical binding]; other site 858619007368 oxyanion hole (OAH) forming residues; other site 858619007369 trimer interface [polypeptide binding]; other site 858619007370 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619007371 active site 858619007372 KMSKS motif; other site 858619007373 Predicted transcriptional regulators [Transcription]; Region: COG1695 858619007374 Transcriptional regulator PadR-like family; Region: PadR; cl17335 858619007375 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 858619007376 ABC1 family; Region: ABC1; cl17513 858619007377 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 858619007378 MOSC domain; Region: MOSC; pfam03473 858619007379 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 858619007380 Prostaglandin dehydrogenases; Region: PGDH; cd05288 858619007381 NAD(P) binding site [chemical binding]; other site 858619007382 substrate binding site [chemical binding]; other site 858619007383 dimer interface [polypeptide binding]; other site 858619007384 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 858619007385 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 858619007386 MMPL family; Region: MMPL; pfam03176 858619007387 MMPL family; Region: MMPL; pfam03176 858619007388 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 858619007389 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 858619007390 catalytic triad [active] 858619007391 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 858619007392 nucleoside/Zn binding site; other site 858619007393 dimer interface [polypeptide binding]; other site 858619007394 catalytic motif [active] 858619007395 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 858619007396 Prephenate dehydrogenase; Region: PDH; pfam02153 858619007397 prephenate dehydrogenase; Validated; Region: PRK08507 858619007398 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 858619007399 beta-lactamase TEM; Provisional; Region: PRK15442 858619007400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 858619007401 Histidine kinase; Region: HisKA_3; pfam07730 858619007402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619007403 ATP binding site [chemical binding]; other site 858619007404 Mg2+ binding site [ion binding]; other site 858619007405 G-X-G motif; other site 858619007406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619007407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619007408 active site 858619007409 phosphorylation site [posttranslational modification] 858619007410 intermolecular recognition site; other site 858619007411 dimerization interface [polypeptide binding]; other site 858619007412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619007413 DNA binding residues [nucleotide binding] 858619007414 dimerization interface [polypeptide binding]; other site 858619007415 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 858619007416 Condensation domain; Region: Condensation; pfam00668 858619007417 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 858619007418 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 858619007419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619007420 short chain dehydrogenase; Provisional; Region: PRK08251 858619007421 NAD(P) binding site [chemical binding]; other site 858619007422 active site 858619007423 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 858619007424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 858619007425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619007426 homodimer interface [polypeptide binding]; other site 858619007427 catalytic residue [active] 858619007428 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 858619007429 Septum formation; Region: Septum_form; pfam13845 858619007430 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 858619007431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619007432 S-adenosylmethionine binding site [chemical binding]; other site 858619007433 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 858619007434 FAD binding domain; Region: FAD_binding_4; pfam01565 858619007435 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 858619007436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 858619007437 ATP binding site [chemical binding]; other site 858619007438 putative Mg++ binding site [ion binding]; other site 858619007439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 858619007440 nucleotide binding region [chemical binding]; other site 858619007441 ATP-binding site [chemical binding]; other site 858619007442 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 858619007443 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 858619007444 Predicted membrane protein [Function unknown]; Region: COG2261 858619007445 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 858619007446 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 858619007447 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 858619007448 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 858619007449 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 858619007450 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 858619007451 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 858619007452 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 858619007453 XdhC Rossmann domain; Region: XdhC_C; pfam13478 858619007454 Protein of unknown function, DUF488; Region: DUF488; cl01246 858619007455 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 858619007456 FMN binding site [chemical binding]; other site 858619007457 substrate binding site [chemical binding]; other site 858619007458 putative catalytic residue [active] 858619007459 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 858619007460 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 858619007461 trimer interface [polypeptide binding]; other site 858619007462 putative metal binding site [ion binding]; other site 858619007463 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 858619007464 NAD-dependent deacetylase; Provisional; Region: PRK00481 858619007465 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 858619007466 NAD+ binding site [chemical binding]; other site 858619007467 substrate binding site [chemical binding]; other site 858619007468 Zn binding site [ion binding]; other site 858619007469 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 858619007470 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619007471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619007472 non-specific DNA binding site [nucleotide binding]; other site 858619007473 salt bridge; other site 858619007474 sequence-specific DNA binding site [nucleotide binding]; other site 858619007475 UreD urease accessory protein; Region: UreD; pfam01774 858619007476 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 858619007477 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 858619007478 UreF; Region: UreF; pfam01730 858619007479 urease subunit alpha; Reviewed; Region: ureC; PRK13207 858619007480 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 858619007481 subunit interactions [polypeptide binding]; other site 858619007482 active site 858619007483 flap region; other site 858619007484 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 858619007485 alpha-beta subunit interface [polypeptide binding]; other site 858619007486 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 858619007487 alpha-gamma subunit interface [polypeptide binding]; other site 858619007488 beta-gamma subunit interface [polypeptide binding]; other site 858619007489 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 858619007490 Protein of unknown function (DUF461); Region: DUF461; pfam04314 858619007491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619007492 dimerization interface [polypeptide binding]; other site 858619007493 putative DNA binding site [nucleotide binding]; other site 858619007494 putative Zn2+ binding site [ion binding]; other site 858619007495 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 858619007496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 858619007497 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 858619007498 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619007499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619007500 ABC-ATPase subunit interface; other site 858619007501 dimer interface [polypeptide binding]; other site 858619007502 putative PBP binding regions; other site 858619007503 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 858619007504 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619007505 intersubunit interface [polypeptide binding]; other site 858619007506 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619007507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619007508 Walker A/P-loop; other site 858619007509 ATP binding site [chemical binding]; other site 858619007510 Q-loop/lid; other site 858619007511 ABC transporter signature motif; other site 858619007512 Walker B; other site 858619007513 D-loop; other site 858619007514 H-loop/switch region; other site 858619007515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619007516 S-adenosylmethionine binding site [chemical binding]; other site 858619007517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619007518 NAD(P) binding site [chemical binding]; other site 858619007519 active site 858619007520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619007521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619007522 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 858619007523 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 858619007524 YibE/F-like protein; Region: YibE_F; pfam07907 858619007525 potential frameshift: common BLAST hit: gi|23577976|ref|NP_702924.1| putative transposase 858619007526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619007527 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619007528 MULE transposase domain; Region: MULE; pfam10551 858619007529 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 858619007530 aspartate racemase; Region: asp_race; TIGR00035 858619007531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619007532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619007533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619007534 putative substrate translocation pore; other site 858619007535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619007536 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 858619007537 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 858619007538 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 858619007539 Na binding site [ion binding]; other site 858619007540 putative substrate binding site [chemical binding]; other site 858619007541 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 858619007542 allantoinase; Region: allantoinase; TIGR03178 858619007543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 858619007544 active site 858619007545 allantoicase; Provisional; Region: PRK13257 858619007546 Allantoicase repeat; Region: Allantoicase; pfam03561 858619007547 Allantoicase repeat; Region: Allantoicase; pfam03561 858619007548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619007549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619007550 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 858619007551 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 858619007552 amphipathic channel; other site 858619007553 Asn-Pro-Ala signature motifs; other site 858619007554 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN03002 858619007555 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 858619007556 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 858619007557 xanthine permease; Region: pbuX; TIGR03173 858619007558 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 858619007559 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 858619007560 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 858619007561 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 858619007562 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 858619007563 dimer interface [polypeptide binding]; other site 858619007564 acyl-activating enzyme (AAE) consensus motif; other site 858619007565 putative active site [active] 858619007566 AMP binding site [chemical binding]; other site 858619007567 putative CoA binding site [chemical binding]; other site 858619007568 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 858619007569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619007570 NAD(P) binding site [chemical binding]; other site 858619007571 active site 858619007572 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 858619007573 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 858619007574 active site 858619007575 non-prolyl cis peptide bond; other site 858619007576 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 858619007577 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 858619007578 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 858619007579 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 858619007580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 858619007581 active site 858619007582 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 858619007583 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 858619007584 FMN-binding pocket [chemical binding]; other site 858619007585 flavin binding motif; other site 858619007586 phosphate binding motif [ion binding]; other site 858619007587 beta-alpha-beta structure motif; other site 858619007588 NAD binding pocket [chemical binding]; other site 858619007589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 858619007590 catalytic loop [active] 858619007591 iron binding site [ion binding]; other site 858619007592 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 858619007593 cytosine deaminase; Validated; Region: PRK07572 858619007594 active site 858619007595 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 858619007596 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 858619007597 Walker A/P-loop; other site 858619007598 ATP binding site [chemical binding]; other site 858619007599 Q-loop/lid; other site 858619007600 ABC transporter signature motif; other site 858619007601 Walker B; other site 858619007602 D-loop; other site 858619007603 H-loop/switch region; other site 858619007604 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 858619007605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619007606 dimer interface [polypeptide binding]; other site 858619007607 conserved gate region; other site 858619007608 putative PBP binding loops; other site 858619007609 ABC-ATPase subunit interface; other site 858619007610 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 858619007611 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 858619007612 FAD binding domain; Region: FAD_binding_4; pfam01565 858619007613 Creatinine amidohydrolase; Region: Creatininase; pfam02633 858619007614 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 858619007615 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 858619007616 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 858619007617 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 858619007618 active site 858619007619 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 858619007620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619007621 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 858619007622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619007623 isovaleryl-CoA dehydrogenase; Region: PLN02519 858619007624 active site 858619007625 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 858619007626 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 858619007627 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 858619007628 Protein of unknown function DUF58; Region: DUF58; pfam01882 858619007629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 858619007630 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 858619007631 Walker A motif; other site 858619007632 ATP binding site [chemical binding]; other site 858619007633 Walker B motif; other site 858619007634 arginine finger; other site 858619007635 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 858619007636 active site 858619007637 homotetramer interface [polypeptide binding]; other site 858619007638 putative OHCU decarboxylase; Provisional; Region: PRK13798 858619007639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 858619007640 guanine deaminase; Provisional; Region: PRK09228 858619007641 active site 858619007642 xanthine permease; Region: pbuX; TIGR03173 858619007643 Riboflavin kinase; Region: Flavokinase; smart00904 858619007644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619007645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619007646 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 858619007647 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 858619007648 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 858619007649 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 858619007650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619007651 dimer interface [polypeptide binding]; other site 858619007652 conserved gate region; other site 858619007653 putative PBP binding loops; other site 858619007654 ABC-ATPase subunit interface; other site 858619007655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619007656 dimer interface [polypeptide binding]; other site 858619007657 conserved gate region; other site 858619007658 putative PBP binding loops; other site 858619007659 ABC-ATPase subunit interface; other site 858619007660 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 858619007661 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 858619007662 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 858619007663 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 858619007664 Walker A/P-loop; other site 858619007665 ATP binding site [chemical binding]; other site 858619007666 Q-loop/lid; other site 858619007667 ABC transporter signature motif; other site 858619007668 Walker B; other site 858619007669 D-loop; other site 858619007670 H-loop/switch region; other site 858619007671 TOBE domain; Region: TOBE_2; pfam08402 858619007672 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 858619007673 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 858619007674 active site 858619007675 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 858619007676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 858619007677 putative DNA binding site [nucleotide binding]; other site 858619007678 putative Zn2+ binding site [ion binding]; other site 858619007679 AsnC family; Region: AsnC_trans_reg; pfam01037 858619007680 hypothetical protein; Provisional; Region: PRK06541 858619007681 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619007682 inhibitor-cofactor binding pocket; inhibition site 858619007683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619007684 catalytic residue [active] 858619007685 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 858619007686 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 858619007687 metal binding site [ion binding]; metal-binding site 858619007688 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 858619007689 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 858619007690 homotrimer interaction site [polypeptide binding]; other site 858619007691 putative active site [active] 858619007692 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 858619007693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619007694 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 858619007695 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 858619007696 NAD(P) binding site [chemical binding]; other site 858619007697 catalytic residues [active] 858619007698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 858619007699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 858619007700 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 858619007701 putative substrate binding pocket [chemical binding]; other site 858619007702 dimerization interface [polypeptide binding]; other site 858619007703 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 858619007704 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 858619007705 amidase; Provisional; Region: PRK07486 858619007706 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 858619007707 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 858619007708 Walker A/P-loop; other site 858619007709 ATP binding site [chemical binding]; other site 858619007710 Q-loop/lid; other site 858619007711 ABC transporter signature motif; other site 858619007712 Walker B; other site 858619007713 D-loop; other site 858619007714 H-loop/switch region; other site 858619007715 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 858619007716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 858619007717 dimer interface [polypeptide binding]; other site 858619007718 conserved gate region; other site 858619007719 putative PBP binding loops; other site 858619007720 ABC-ATPase subunit interface; other site 858619007721 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 858619007722 NMT1-like family; Region: NMT1_2; pfam13379 858619007723 membrane-bound complex binding site; other site 858619007724 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 858619007725 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 858619007726 active site 858619007727 hydrophobic ligand binding site; other site 858619007728 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 858619007729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619007730 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 858619007731 NAD(P) binding site [chemical binding]; other site 858619007732 active site 858619007733 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 858619007734 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 858619007735 cofactor binding site; other site 858619007736 DNA binding site [nucleotide binding] 858619007737 substrate interaction site [chemical binding]; other site 858619007738 benzoate transport; Region: 2A0115; TIGR00895 858619007739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619007740 putative substrate translocation pore; other site 858619007741 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 858619007742 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 858619007743 FMN-binding pocket [chemical binding]; other site 858619007744 flavin binding motif; other site 858619007745 phosphate binding motif [ion binding]; other site 858619007746 beta-alpha-beta structure motif; other site 858619007747 NAD binding pocket [chemical binding]; other site 858619007748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 858619007749 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 858619007750 catalytic loop [active] 858619007751 iron binding site [ion binding]; other site 858619007752 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 858619007753 Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532 858619007754 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 858619007755 alpha subunit interface [polypeptide binding]; other site 858619007756 active site 858619007757 substrate binding site [chemical binding]; other site 858619007758 Fe binding site [ion binding]; other site 858619007759 Predicted transcriptional regulators [Transcription]; Region: COG1695 858619007760 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 858619007761 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619007762 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619007763 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619007764 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619007765 potential frameshift: common BLAST hit: gi|256824506|ref|YP_003148466.1| transposase 858619007766 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619007767 MULE transposase domain; Region: MULE; pfam10551 858619007768 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 858619007769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619007770 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 858619007771 Transposase; Region: DEDD_Tnp_IS110; pfam01548 858619007772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 858619007773 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619007774 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619007775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619007776 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619007777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619007778 H-loop/switch region; other site 858619007779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619007780 Walker A/P-loop; other site 858619007781 ATP binding site [chemical binding]; other site 858619007782 Q-loop/lid; other site 858619007783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619007784 Walker A/P-loop; other site 858619007785 ATP binding site [chemical binding]; other site 858619007786 Q-loop/lid; other site 858619007787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619007788 ABC transporter signature motif; other site 858619007789 O-succinylbenzoate synthase; Provisional; Region: PRK02901 858619007790 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 858619007791 active site 858619007792 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 858619007793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 858619007794 substrate binding site [chemical binding]; other site 858619007795 oxyanion hole (OAH) forming residues; other site 858619007796 trimer interface [polypeptide binding]; other site 858619007797 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 858619007798 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 858619007799 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619007800 AMP binding site [chemical binding]; other site 858619007801 active site 858619007802 acyl-activating enzyme (AAE) consensus motif; other site 858619007803 CoA binding site [chemical binding]; other site 858619007804 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 858619007805 UbiA prenyltransferase family; Region: UbiA; pfam01040 858619007806 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 858619007807 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 858619007808 putative active site [active] 858619007809 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 858619007810 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 858619007811 substrate binding site; other site 858619007812 tetramer interface; other site 858619007813 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 858619007814 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 858619007815 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 858619007816 FAD binding pocket [chemical binding]; other site 858619007817 FAD binding motif [chemical binding]; other site 858619007818 phosphate binding motif [ion binding]; other site 858619007819 beta-alpha-beta structure motif; other site 858619007820 NAD binding pocket [chemical binding]; other site 858619007821 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 858619007822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 858619007823 catalytic loop [active] 858619007824 iron binding site [ion binding]; other site 858619007825 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 858619007826 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 858619007827 putative di-iron ligands [ion binding]; other site 858619007828 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 858619007829 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 858619007830 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 858619007831 NAD binding site [chemical binding]; other site 858619007832 substrate binding site [chemical binding]; other site 858619007833 homodimer interface [polypeptide binding]; other site 858619007834 active site 858619007835 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 858619007836 ResB-like family; Region: ResB; pfam05140 858619007837 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 858619007838 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 858619007839 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 858619007840 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 858619007841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 858619007842 catalytic residues [active] 858619007843 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619007844 catalytic core [active] 858619007845 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 858619007846 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619007847 siderophore binding site; other site 858619007848 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 858619007849 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619007850 inhibitor-cofactor binding pocket; inhibition site 858619007851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619007852 catalytic residue [active] 858619007853 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 858619007854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619007855 Soluble P-type ATPase [General function prediction only]; Region: COG4087 858619007856 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 858619007857 dimer interface [polypeptide binding]; other site 858619007858 active site 858619007859 Schiff base residues; other site 858619007860 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 858619007861 Predicted membrane protein [Function unknown]; Region: COG1511 858619007862 Predicted membrane protein [Function unknown]; Region: COG1511 858619007863 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 858619007864 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 858619007865 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 858619007866 active site 858619007867 homodimer interface [polypeptide binding]; other site 858619007868 SAM binding site [chemical binding]; other site 858619007869 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 858619007870 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 858619007871 active site 858619007872 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 858619007873 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 858619007874 domain interfaces; other site 858619007875 active site 858619007876 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 858619007877 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 858619007878 tRNA; other site 858619007879 putative tRNA binding site [nucleotide binding]; other site 858619007880 putative NADP binding site [chemical binding]; other site 858619007881 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 858619007882 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 858619007883 DNA binding domain, excisionase family; Region: excise; TIGR01764 858619007884 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 858619007885 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 858619007886 exopolyphosphatase; Region: exo_poly_only; TIGR03706 858619007887 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 858619007888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 858619007889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619007890 active site 858619007891 phosphorylation site [posttranslational modification] 858619007892 intermolecular recognition site; other site 858619007893 dimerization interface [polypeptide binding]; other site 858619007894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 858619007895 DNA binding site [nucleotide binding] 858619007896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 858619007897 dimer interface [polypeptide binding]; other site 858619007898 phosphorylation site [posttranslational modification] 858619007899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619007900 ATP binding site [chemical binding]; other site 858619007901 Mg2+ binding site [ion binding]; other site 858619007902 G-X-G motif; other site 858619007903 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619007904 catalytic core [active] 858619007905 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 858619007906 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 858619007907 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 858619007908 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 858619007909 putative ADP-binding pocket [chemical binding]; other site 858619007910 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 858619007911 FAD binding domain; Region: FAD_binding_4; pfam01565 858619007912 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 858619007913 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 858619007914 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 858619007915 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 858619007916 intersubunit interface [polypeptide binding]; other site 858619007917 active site 858619007918 catalytic residue [active] 858619007919 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 858619007920 Predicted membrane protein [Function unknown]; Region: COG2733 858619007921 oxidoreductase; Provisional; Region: PRK06128 858619007922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619007923 NAD(P) binding site [chemical binding]; other site 858619007924 active site 858619007925 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 858619007926 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 858619007927 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 858619007928 L-aspartate oxidase; Provisional; Region: PRK06175 858619007929 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 858619007930 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 858619007931 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 858619007932 putative Iron-sulfur protein interface [polypeptide binding]; other site 858619007933 proximal heme binding site [chemical binding]; other site 858619007934 distal heme binding site [chemical binding]; other site 858619007935 putative dimer interface [polypeptide binding]; other site 858619007936 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 858619007937 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 858619007938 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 858619007939 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 858619007940 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 858619007941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 858619007942 motif I; other site 858619007943 motif II; other site 858619007944 malate synthase G; Provisional; Region: PRK02999 858619007945 active site 858619007946 isocitrate lyase; Provisional; Region: PRK15063 858619007947 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 858619007948 tetramer interface [polypeptide binding]; other site 858619007949 active site 858619007950 Mg2+/Mn2+ binding site [ion binding]; other site 858619007951 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 858619007952 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 858619007953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619007954 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 858619007955 Predicted esterase [General function prediction only]; Region: COG0627 858619007956 Predicted esterase [General function prediction only]; Region: COG0627 858619007957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619007958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619007959 putative substrate translocation pore; other site 858619007960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619007961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619007962 active site 858619007963 hypothetical protein; Provisional; Region: PRK11770 858619007964 Domain of unknown function (DUF307); Region: DUF307; pfam03733 858619007965 Domain of unknown function (DUF307); Region: DUF307; pfam03733 858619007966 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 858619007967 TIGR03086 family protein; Region: TIGR03086 858619007968 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619007969 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619007970 potential frameshift: common BLAST hit: gi|256824506|ref|YP_003148466.1| transposase 858619007971 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619007972 MULE transposase domain; Region: MULE; pfam10551 858619007973 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 858619007974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619007975 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 858619007976 Transposase; Region: DEDD_Tnp_IS110; pfam01548 858619007977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 858619007978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619007979 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619007980 potential frameshift: common BLAST hit: gi|256832661|ref|YP_003161388.1| transposase IS204/IS1001/IS1096/IS1165 family protein 858619007981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619007982 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619007983 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619007984 MULE transposase domain; Region: MULE; pfam10551 858619007985 Transposase; Region: HTH_Tnp_1; cl17663 858619007986 Integrase core domain; Region: rve; pfam00665 858619007987 Integrase core domain; Region: rve_3; cl15866 858619007988 multiple promoter invertase; Provisional; Region: mpi; PRK13413 858619007989 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 858619007990 catalytic residues [active] 858619007991 catalytic nucleophile [active] 858619007992 Presynaptic Site I dimer interface [polypeptide binding]; other site 858619007993 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 858619007994 Synaptic Flat tetramer interface [polypeptide binding]; other site 858619007995 Synaptic Site I dimer interface [polypeptide binding]; other site 858619007996 DNA binding site [nucleotide binding] 858619007997 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 858619007998 DNA-binding interface [nucleotide binding]; DNA binding site 858619007999 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 858619008000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 858619008001 potential frameshift: common BLAST hit: gi|23578022|ref|NP_702969.1| putative transposase 858619008002 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008003 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008004 MULE transposase domain; Region: MULE; pfam10551 858619008005 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619008006 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619008007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619008008 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 858619008009 RNA/DNA hybrid binding site [nucleotide binding]; other site 858619008010 active site 858619008011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619008012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619008013 active site 858619008014 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619008015 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619008016 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619008017 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 858619008018 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 858619008019 Walker A/P-loop; other site 858619008020 ATP binding site [chemical binding]; other site 858619008021 Q-loop/lid; other site 858619008022 ABC transporter signature motif; other site 858619008023 Walker B; other site 858619008024 D-loop; other site 858619008025 H-loop/switch region; other site 858619008026 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 858619008027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619008028 ABC-ATPase subunit interface; other site 858619008029 dimer interface [polypeptide binding]; other site 858619008030 putative PBP binding regions; other site 858619008031 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 858619008032 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 858619008033 ABC-ATPase subunit interface; other site 858619008034 dimer interface [polypeptide binding]; other site 858619008035 putative PBP binding regions; other site 858619008036 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008037 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619008038 intersubunit interface [polypeptide binding]; other site 858619008039 Cupin domain; Region: Cupin_2; cl17218 858619008040 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 858619008041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619008042 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619008043 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008044 intersubunit interface [polypeptide binding]; other site 858619008045 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008046 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619008047 intersubunit interface [polypeptide binding]; other site 858619008048 Helix-turn-helix domain; Region: HTH_18; pfam12833 858619008049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619008050 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 858619008051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619008052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619008053 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619008054 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619008055 FAD binding pocket [chemical binding]; other site 858619008056 FAD binding motif [chemical binding]; other site 858619008057 phosphate binding motif [ion binding]; other site 858619008058 NAD binding pocket [chemical binding]; other site 858619008059 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008060 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619008061 intersubunit interface [polypeptide binding]; other site 858619008062 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 858619008063 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008064 intersubunit interface [polypeptide binding]; other site 858619008065 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619008066 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008067 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619008068 intersubunit interface [polypeptide binding]; other site 858619008069 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 858619008070 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619008071 intersubunit interface [polypeptide binding]; other site 858619008072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619008073 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 858619008074 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 858619008075 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 858619008076 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 858619008077 putative deacylase active site [active] 858619008078 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 858619008079 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 858619008080 Lsr2; Region: Lsr2; pfam11774 858619008081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619008082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619008083 active site 858619008084 phosphorylation site [posttranslational modification] 858619008085 intermolecular recognition site; other site 858619008086 dimerization interface [polypeptide binding]; other site 858619008087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619008088 DNA binding residues [nucleotide binding] 858619008089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 858619008090 Histidine kinase; Region: HisKA_3; pfam07730 858619008091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619008092 ATP binding site [chemical binding]; other site 858619008093 Mg2+ binding site [ion binding]; other site 858619008094 G-X-G motif; other site 858619008095 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 858619008096 putative transposase OrfB; Reviewed; Region: PHA02517 858619008097 HTH-like domain; Region: HTH_21; pfam13276 858619008098 Integrase core domain; Region: rve; pfam00665 858619008099 Integrase core domain; Region: rve_3; pfam13683 858619008100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619008101 Transposase; Region: HTH_Tnp_1; pfam01527 858619008102 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 858619008103 isochorismate synthase EntC; Provisional; Region: PRK15016 858619008104 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 858619008105 Phosphopantetheine attachment site; Region: PP-binding; cl09936 858619008106 Condensation domain; Region: Condensation; pfam00668 858619008107 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 858619008108 Nonribosomal peptide synthase; Region: NRPS; pfam08415 858619008109 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 858619008110 acyl-activating enzyme (AAE) consensus motif; other site 858619008111 AMP binding site [chemical binding]; other site 858619008112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 858619008113 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 858619008114 Condensation domain; Region: Condensation; pfam00668 858619008115 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 858619008116 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 858619008117 acyl-activating enzyme (AAE) consensus motif; other site 858619008118 AMP binding site [chemical binding]; other site 858619008119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 858619008120 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 858619008121 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 858619008122 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 858619008123 acyl-activating enzyme (AAE) consensus motif; other site 858619008124 AMP binding site [chemical binding]; other site 858619008125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 858619008126 Condensation domain; Region: Condensation; pfam00668 858619008127 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 858619008128 Condensation domain; Region: Condensation; pfam00668 858619008129 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 858619008130 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 858619008131 acyl-activating enzyme (AAE) consensus motif; other site 858619008132 AMP binding site [chemical binding]; other site 858619008133 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 858619008134 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 858619008135 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 858619008136 Condensation domain; Region: Condensation; pfam00668 858619008137 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 858619008138 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 858619008139 acyl-activating enzyme (AAE) consensus motif; other site 858619008140 AMP binding site [chemical binding]; other site 858619008141 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 858619008142 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 858619008143 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 858619008144 acyl-activating enzyme (AAE) consensus motif; other site 858619008145 active site 858619008146 AMP binding site [chemical binding]; other site 858619008147 substrate binding site [chemical binding]; other site 858619008148 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 858619008149 tetramerization interface [polypeptide binding]; other site 858619008150 active site 858619008151 MbtH-like protein; Region: MbtH; cl01279 858619008152 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 858619008153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619008154 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008155 MULE transposase domain; Region: MULE; pfam10551 858619008156 Helix-turn-helix domain; Region: HTH_18; pfam12833 858619008157 Cupin domain; Region: Cupin_2; cl17218 858619008158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 858619008159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 858619008160 benzoate transport; Region: 2A0115; TIGR00895 858619008161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619008162 putative substrate translocation pore; other site 858619008163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619008164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 858619008165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619008166 Walker A/P-loop; other site 858619008167 ATP binding site [chemical binding]; other site 858619008168 Q-loop/lid; other site 858619008169 ABC transporter signature motif; other site 858619008170 Walker B; other site 858619008171 D-loop; other site 858619008172 H-loop/switch region; other site 858619008173 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 858619008174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619008175 Walker A/P-loop; other site 858619008176 ATP binding site [chemical binding]; other site 858619008177 Q-loop/lid; other site 858619008178 ABC transporter signature motif; other site 858619008179 Walker B; other site 858619008180 D-loop; other site 858619008181 H-loop/switch region; other site 858619008182 HipA N-terminal domain; Region: Couple_hipA; cl11853 858619008183 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 858619008184 HipA-like N-terminal domain; Region: HipA_N; pfam07805 858619008185 HipA-like C-terminal domain; Region: HipA_C; pfam07804 858619008186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 858619008187 DNA binding residues [nucleotide binding] 858619008188 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 858619008189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619008190 non-specific DNA binding site [nucleotide binding]; other site 858619008191 salt bridge; other site 858619008192 sequence-specific DNA binding site [nucleotide binding]; other site 858619008193 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 858619008194 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 858619008195 FAD binding pocket [chemical binding]; other site 858619008196 FAD binding motif [chemical binding]; other site 858619008197 phosphate binding motif [ion binding]; other site 858619008198 NAD binding pocket [chemical binding]; other site 858619008199 O-methyltransferase; Region: Methyltransf_2; pfam00891 858619008200 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619008201 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619008202 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619008203 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 858619008204 dimer interface [polypeptide binding]; other site 858619008205 catalytic triad [active] 858619008206 peroxidatic and resolving cysteines [active] 858619008207 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 858619008208 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 858619008209 active site 858619008210 catalytic site [active] 858619008211 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 858619008212 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 858619008213 active site 858619008214 nucleophile elbow; other site 858619008215 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 858619008216 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 858619008217 NAD binding site [chemical binding]; other site 858619008218 dimer interface [polypeptide binding]; other site 858619008219 tetramer (dimer of dimers) interface [polypeptide binding]; other site 858619008220 substrate binding site [chemical binding]; other site 858619008221 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 858619008222 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 858619008223 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 858619008224 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 858619008225 putative deacylase active site [active] 858619008226 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 858619008227 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 858619008228 Lsr2; Region: Lsr2; pfam11774 858619008229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 858619008230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 858619008231 active site 858619008232 phosphorylation site [posttranslational modification] 858619008233 intermolecular recognition site; other site 858619008234 dimerization interface [polypeptide binding]; other site 858619008235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 858619008236 DNA binding residues [nucleotide binding] 858619008237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 858619008238 Histidine kinase; Region: HisKA_3; pfam07730 858619008239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 858619008240 ATP binding site [chemical binding]; other site 858619008241 Mg2+ binding site [ion binding]; other site 858619008242 G-X-G motif; other site 858619008243 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 858619008244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619008245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619008246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619008247 Ligand Binding Site [chemical binding]; other site 858619008248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619008249 Ligand Binding Site [chemical binding]; other site 858619008250 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 858619008251 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 858619008252 active site 858619008253 Transposase [DNA replication, recombination, and repair]; Region: COG5421 858619008254 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 858619008255 potential frameshift: common BLAST hit: gi|77454838|ref|YP_345706.1| putative transposase 858619008256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619008257 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619008258 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 858619008259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 858619008260 Walker A/P-loop; other site 858619008261 ATP binding site [chemical binding]; other site 858619008262 Q-loop/lid; other site 858619008263 Walker B; other site 858619008264 D-loop; other site 858619008265 Predicted transcriptional regulators [Transcription]; Region: COG1725 858619008266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 858619008267 DNA-binding site [nucleotide binding]; DNA binding site 858619008268 Uncharacterized protein conserved in archaea (DUF2192); Region: DUF2192; pfam09958 858619008269 LabA_like proteins; Region: LabA_like; cd06167 858619008270 putative metal binding site [ion binding]; other site 858619008271 Uncharacterized conserved protein [Function unknown]; Region: COG1432 858619008272 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 858619008273 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 858619008274 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 858619008275 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 858619008276 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 858619008277 active site 858619008278 Zn binding site [ion binding]; other site 858619008279 Protease prsW family; Region: PrsW-protease; pfam13367 858619008280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619008281 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619008282 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 858619008283 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 858619008284 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 858619008285 active site 858619008286 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 858619008287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 858619008288 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 858619008289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 858619008290 RNA binding surface [nucleotide binding]; other site 858619008291 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 858619008292 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 858619008293 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 858619008294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619008295 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 858619008296 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 858619008297 active site 858619008298 dimer interface [polypeptide binding]; other site 858619008299 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 858619008300 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 858619008301 active site 858619008302 FMN binding site [chemical binding]; other site 858619008303 substrate binding site [chemical binding]; other site 858619008304 3Fe-4S cluster binding site [ion binding]; other site 858619008305 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 858619008306 domain interface; other site 858619008307 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 858619008308 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 858619008309 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 858619008310 NAD(P) binding site [chemical binding]; other site 858619008311 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 858619008312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 858619008313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619008314 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 858619008315 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 858619008316 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 858619008317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 858619008318 S-adenosylmethionine binding site [chemical binding]; other site 858619008319 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 858619008320 metal ion-dependent adhesion site (MIDAS); other site 858619008321 Tubulin like; Region: Tubulin_2; pfam13809 858619008322 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 858619008323 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 858619008324 active site 858619008325 Predicted membrane protein [Function unknown]; Region: COG2246 858619008326 GtrA-like protein; Region: GtrA; pfam04138 858619008327 Predicted membrane protein [Function unknown]; Region: COG2246 858619008328 GtrA-like protein; Region: GtrA; pfam04138 858619008329 Protein of unknown function (DUF419); Region: DUF419; pfam04237 858619008330 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 858619008331 FAD binding domain; Region: FAD_binding_4; pfam01565 858619008332 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 858619008333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619008334 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 858619008335 NAD(P) binding site [chemical binding]; other site 858619008336 active site 858619008337 Fic family protein [Function unknown]; Region: COG3177 858619008338 Fic/DOC family; Region: Fic; pfam02661 858619008339 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 858619008340 metal-binding site [ion binding] 858619008341 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 858619008342 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 858619008343 metal-binding site [ion binding] 858619008344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619008345 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 858619008346 Low molecular weight phosphatase family; Region: LMWPc; cl00105 858619008347 active site 858619008348 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 858619008349 arsenical-resistance protein; Region: acr3; TIGR00832 858619008350 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 858619008351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 858619008352 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 858619008353 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 858619008354 FMN binding site [chemical binding]; other site 858619008355 active site 858619008356 substrate binding site [chemical binding]; other site 858619008357 catalytic residue [active] 858619008358 Fructosamine kinase; Region: Fructosamin_kin; cl17579 858619008359 Phosphotransferase enzyme family; Region: APH; pfam01636 858619008360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619008361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619008362 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 858619008363 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 858619008364 dimer interface [polypeptide binding]; other site 858619008365 active site 858619008366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619008367 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 858619008368 NAD(P) binding site [chemical binding]; other site 858619008369 active site 858619008370 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 858619008371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619008372 NAD(P) binding site [chemical binding]; other site 858619008373 active site 858619008374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619008375 putative substrate translocation pore; other site 858619008376 potential frameshift: common BLAST hit: gi|77454753|ref|YP_345621.1| putative lipase 858619008377 Secretory lipase; Region: LIP; pfam03583 858619008378 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 858619008379 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 858619008380 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 858619008381 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 858619008382 Helix-turn-helix domain; Region: HTH_17; pfam12728 858619008383 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 858619008384 AAA domain; Region: AAA_17; cl17253 858619008385 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 858619008386 AAA domain; Region: AAA_33; pfam13671 858619008387 ATP-binding site [chemical binding]; other site 858619008388 Gluconate-6-phosphate binding site [chemical binding]; other site 858619008389 fructuronate transporter; Provisional; Region: PRK10034; cl15264 858619008390 fructuronate transporter; Provisional; Region: PRK10034; cl15264 858619008391 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 858619008392 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 858619008393 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 858619008394 inhibitor-cofactor binding pocket; inhibition site 858619008395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 858619008396 catalytic residue [active] 858619008397 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 858619008398 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 858619008399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619008400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619008401 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 858619008402 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 858619008403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 858619008404 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 858619008405 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 858619008406 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 858619008407 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 858619008408 NAD(P) binding site [chemical binding]; other site 858619008409 catalytic residues [active] 858619008410 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 858619008411 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 858619008412 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 858619008413 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 858619008414 putative dimer interface [polypeptide binding]; other site 858619008415 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 858619008416 Integrase core domain; Region: rve_3; cl15866 858619008417 HTH-like domain; Region: HTH_21; pfam13276 858619008418 Integrase core domain; Region: rve; pfam00665 858619008419 Transposase; Region: HTH_Tnp_1; pfam01527 858619008420 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619008421 potential frameshift: common BLAST hit: gi|23577976|ref|NP_702924.1| putative transposase 858619008422 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008423 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008424 MULE transposase domain; Region: MULE; pfam10551 858619008425 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 858619008426 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 858619008427 Na binding site [ion binding]; other site 858619008428 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 858619008429 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 858619008430 active site 858619008431 putative substrate binding pocket [chemical binding]; other site 858619008432 Transposase; Region: HTH_Tnp_1; pfam01527 858619008433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619008434 putative transposase OrfB; Reviewed; Region: PHA02517 858619008435 HTH-like domain; Region: HTH_21; pfam13276 858619008436 Integrase core domain; Region: rve; pfam00665 858619008437 Integrase core domain; Region: rve_3; pfam13683 858619008438 Transposase; Region: HTH_Tnp_1; pfam01527 858619008439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 858619008440 HTH-like domain; Region: HTH_21; pfam13276 858619008441 Integrase core domain; Region: rve; pfam00665 858619008442 Transposase; Region: HTH_Tnp_1; cl17663 858619008443 HTH-like domain; Region: HTH_21; pfam13276 858619008444 Integrase core domain; Region: rve; pfam00665 858619008445 Integrase core domain; Region: rve_3; cl15866 858619008446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 858619008447 L-tyrosine decarboxylase; Provisional; Region: PRK13520 858619008448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 858619008449 catalytic residue [active] 858619008450 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 858619008451 catalytic residues [active] 858619008452 dimer interface [polypeptide binding]; other site 858619008453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619008454 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 858619008455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 858619008456 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 858619008457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 858619008458 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 858619008459 acyl-activating enzyme (AAE) consensus motif; other site 858619008460 putative AMP binding site [chemical binding]; other site 858619008461 putative active site [active] 858619008462 acyl-activating enzyme (AAE) consensus motif; other site 858619008463 putative CoA binding site [chemical binding]; other site 858619008464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619008465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619008466 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 858619008467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 858619008468 active site 858619008469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 858619008470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 858619008471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 858619008472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 858619008473 putative substrate translocation pore; other site 858619008474 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 858619008475 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 858619008476 catalytic residues [active] 858619008477 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 858619008478 CoenzymeA binding site [chemical binding]; other site 858619008479 subunit interaction site [polypeptide binding]; other site 858619008480 PHB binding site; other site 858619008481 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 858619008482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 858619008483 NAD(P) binding site [chemical binding]; other site 858619008484 active site 858619008485 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 858619008486 Uncharacterized conserved protein [Function unknown]; Region: COG2353 858619008487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 858619008488 MarR family; Region: MarR_2; pfam12802 858619008489 replicative DNA helicase; Region: DnaB; TIGR00665 858619008490 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 858619008491 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 858619008492 Walker A motif; other site 858619008493 ATP binding site [chemical binding]; other site 858619008494 Walker B motif; other site 858619008495 DNA binding loops [nucleotide binding] 858619008496 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 858619008497 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 858619008498 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 858619008499 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 858619008500 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 858619008501 dimer interface [polypeptide binding]; other site 858619008502 ssDNA binding site [nucleotide binding]; other site 858619008503 tetramer (dimer of dimers) interface [polypeptide binding]; other site 858619008504 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 858619008505 Transglycosylase; Region: Transgly; pfam00912 858619008506 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 858619008507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 858619008508 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 858619008509 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 858619008510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 858619008511 MarR family; Region: MarR_2; cl17246 858619008512 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619008513 Ligand Binding Site [chemical binding]; other site 858619008514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 858619008515 Ligand Binding Site [chemical binding]; other site 858619008516 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 858619008517 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619008518 active site 858619008519 HIGH motif; other site 858619008520 nucleotide binding site [chemical binding]; other site 858619008521 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 858619008522 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619008523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 858619008524 active site 858619008525 KMSKS motif; other site 858619008526 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 858619008527 tRNA binding surface [nucleotide binding]; other site 858619008528 SdpI/YhfL protein family; Region: SdpI; pfam13630 858619008529 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 858619008530 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 858619008531 Soluble P-type ATPase [General function prediction only]; Region: COG4087 858619008532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 858619008533 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 858619008534 substrate binding site [chemical binding]; other site 858619008535 dimer interface [polypeptide binding]; other site 858619008536 ATP binding site [chemical binding]; other site 858619008537 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 858619008538 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 858619008539 Divergent AAA domain; Region: AAA_4; pfam04326 858619008540 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 858619008541 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 858619008542 nudix motif; other site 858619008543 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 858619008544 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 858619008545 siderophore binding site; other site 858619008546 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 858619008547 AzlC protein; Region: AzlC; cl00570 858619008548 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 858619008549 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 858619008550 active site 858619008551 NTP binding site [chemical binding]; other site 858619008552 metal binding triad [ion binding]; metal-binding site 858619008553 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 858619008554 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 858619008555 Zn2+ binding site [ion binding]; other site 858619008556 Mg2+ binding site [ion binding]; other site 858619008557 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 858619008558 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 858619008559 active site 858619008560 Ap6A binding site [chemical binding]; other site 858619008561 nudix motif; other site 858619008562 metal binding site [ion binding]; metal-binding site 858619008563 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 858619008564 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 858619008565 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 858619008566 proline aminopeptidase P II; Provisional; Region: PRK10879 858619008567 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 858619008568 active site 858619008569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 858619008570 sequence-specific DNA binding site [nucleotide binding]; other site 858619008571 salt bridge; other site 858619008572 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 858619008573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 858619008574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 858619008575 DNA binding residues [nucleotide binding] 858619008576 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 858619008577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 858619008578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619008579 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 858619008580 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 858619008581 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 858619008582 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 858619008583 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 858619008584 active site 858619008585 metal binding site [ion binding]; metal-binding site 858619008586 Transposase; Region: DDE_Tnp_ISL3; pfam01610 858619008587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 858619008588 potential frameshift: common BLAST hit: gi|256824506|ref|YP_003148466.1| transposase 858619008589 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008590 MULE transposase domain; Region: MULE; pfam10551 858619008591 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 858619008592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 858619008593 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 858619008594 Transposase; Region: DEDD_Tnp_IS110; pfam01548 858619008595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 858619008596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 858619008597 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 858619008598 Transposase, Mutator family; Region: Transposase_mut; pfam00872 858619008599 MULE transposase domain; Region: MULE; pfam10551 858619008600 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 858619008601 ParB-like nuclease domain; Region: ParBc; pfam02195 858619008602 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 858619008603 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 858619008604 P-loop; other site 858619008605 Magnesium ion binding site [ion binding]; other site 858619008606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 858619008607 Magnesium ion binding site [ion binding]; other site 858619008608 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 858619008609 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 858619008610 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 858619008611 Haemolytic domain; Region: Haemolytic; pfam01809 858619008612 Ribonuclease P; Region: Ribonuclease_P; cl00457 858619008613 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399