-- dump date   	20140619_053226
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
434923000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
434923000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
434923000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923000004	Walker A motif; other site
434923000005	ATP binding site [chemical binding]; other site
434923000006	Walker B motif; other site
434923000007	arginine finger; other site
434923000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
434923000009	DnaA box-binding interface [nucleotide binding]; other site
434923000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
434923000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
434923000012	putative DNA binding surface [nucleotide binding]; other site
434923000013	dimer interface [polypeptide binding]; other site
434923000014	beta-clamp/clamp loader binding surface; other site
434923000015	beta-clamp/translesion DNA polymerase binding surface; other site
434923000016	recombination protein F; Reviewed; Region: recF; PRK00064
434923000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
434923000018	Walker A/P-loop; other site
434923000019	ATP binding site [chemical binding]; other site
434923000020	Q-loop/lid; other site
434923000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
434923000022	ABC transporter signature motif; other site
434923000023	Walker B; other site
434923000024	D-loop; other site
434923000025	H-loop/switch region; other site
434923000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
434923000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923000028	ATP binding site [chemical binding]; other site
434923000029	Mg2+ binding site [ion binding]; other site
434923000030	G-X-G motif; other site
434923000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
434923000032	anchoring element; other site
434923000033	dimer interface [polypeptide binding]; other site
434923000034	ATP binding site [chemical binding]; other site
434923000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
434923000036	active site
434923000037	putative metal-binding site [ion binding]; other site
434923000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
434923000039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000040	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000041	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000042	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
434923000043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923000044	S-adenosylmethionine binding site [chemical binding]; other site
434923000045	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
434923000046	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
434923000047	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
434923000048	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
434923000049	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
434923000050	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
434923000051	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
434923000052	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
434923000053	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
434923000054	P loop; other site
434923000055	GTP binding site [chemical binding]; other site
434923000056	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
434923000057	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
434923000058	Walker A/P-loop; other site
434923000059	ATP binding site [chemical binding]; other site
434923000060	Q-loop/lid; other site
434923000061	ABC transporter signature motif; other site
434923000062	Walker B; other site
434923000063	D-loop; other site
434923000064	H-loop/switch region; other site
434923000065	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
434923000066	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
434923000067	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
434923000068	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
434923000069	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
434923000070	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
434923000071	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
434923000072	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
434923000073	DNA binding residues [nucleotide binding]
434923000074	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
434923000075	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
434923000076	catalytic residues [active]
434923000077	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000078	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
434923000079	dimer interface [polypeptide binding]; other site
434923000080	motif 1; other site
434923000081	active site
434923000082	motif 2; other site
434923000083	motif 3; other site
434923000084	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
434923000085	DALR anticodon binding domain; Region: DALR_1; pfam05746
434923000086	16S rRNA methyltransferase B; Provisional; Region: PRK10901
434923000087	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
434923000088	putative RNA binding site [nucleotide binding]; other site
434923000089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923000090	S-adenosylmethionine binding site [chemical binding]; other site
434923000091	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
434923000092	Ligand Binding Site [chemical binding]; other site
434923000093	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
434923000094	Ribonuclease P; Region: Ribonuclease_P; pfam00825
434923000095	hypothetical protein; Provisional; Region: PRK14384
434923000096	membrane protein insertase; Provisional; Region: PRK01318
434923000097	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
434923000098	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
434923000099	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
434923000100	trmE is a tRNA modification GTPase; Region: trmE; cd04164
434923000101	G1 box; other site
434923000102	GTP/Mg2+ binding site [chemical binding]; other site
434923000103	Switch I region; other site
434923000104	G2 box; other site
434923000105	Switch II region; other site
434923000106	G3 box; other site
434923000107	G4 box; other site
434923000108	G5 box; other site
434923000109	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
434923000110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
434923000111	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
434923000112	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
434923000113	NAD binding site [chemical binding]; other site
434923000114	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
434923000115	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
434923000116	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
434923000117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923000118	S-adenosylmethionine binding site [chemical binding]; other site
434923000119	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
434923000120	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
434923000121	P-loop; other site
434923000122	Magnesium ion binding site [ion binding]; other site
434923000123	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
434923000124	Magnesium ion binding site [ion binding]; other site
434923000125	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
434923000126	ParB-like nuclease domain; Region: ParB; smart00470
434923000127	KorB domain; Region: KorB; pfam08535
434923000128	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
434923000129	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
434923000130	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
434923000131	acyl-activating enzyme (AAE) consensus motif; other site
434923000132	active site
434923000133	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
434923000134	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
434923000135	putative acyl-acceptor binding pocket; other site
434923000136	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
434923000137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923000138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923000139	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
434923000140	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
434923000141	putative DNA binding site [nucleotide binding]; other site
434923000142	putative homodimer interface [polypeptide binding]; other site
434923000143	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
434923000144	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
434923000145	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
434923000146	active site
434923000147	DNA binding site [nucleotide binding]
434923000148	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
434923000149	DNA binding site [nucleotide binding]
434923000150	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
434923000151	nucleotide binding site [chemical binding]; other site
434923000152	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000153	ATP synthase I chain; Region: ATP_synt_I; cl09170
434923000154	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
434923000155	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
434923000156	ATP synthase subunit C; Region: ATP-synt_C; cl00466
434923000157	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
434923000158	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
434923000159	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
434923000160	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
434923000161	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
434923000162	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
434923000163	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
434923000164	beta subunit interaction interface [polypeptide binding]; other site
434923000165	Walker A motif; other site
434923000166	ATP binding site [chemical binding]; other site
434923000167	Walker B motif; other site
434923000168	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
434923000169	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
434923000170	core domain interface [polypeptide binding]; other site
434923000171	delta subunit interface [polypeptide binding]; other site
434923000172	epsilon subunit interface [polypeptide binding]; other site
434923000173	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
434923000174	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
434923000175	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
434923000176	alpha subunit interaction interface [polypeptide binding]; other site
434923000177	Walker A motif; other site
434923000178	ATP binding site [chemical binding]; other site
434923000179	Walker B motif; other site
434923000180	inhibitor binding site; inhibition site
434923000181	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
434923000182	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
434923000183	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
434923000184	gamma subunit interface [polypeptide binding]; other site
434923000185	epsilon subunit interface [polypeptide binding]; other site
434923000186	LBP interface [polypeptide binding]; other site
434923000187	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
434923000188	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
434923000189	Substrate binding site; other site
434923000190	Mg++ binding site; other site
434923000191	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
434923000192	active site
434923000193	substrate binding site [chemical binding]; other site
434923000194	CoA binding site [chemical binding]; other site
434923000195	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000196	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000197	AAA domain; Region: AAA_22; pfam13401
434923000198	AAA domain; Region: AAA_14; pfam13173
434923000199	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
434923000200	active site
434923000201	substrate binding pocket [chemical binding]; other site
434923000202	dimer interface [polypeptide binding]; other site
434923000203	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
434923000204	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
434923000205	active site
434923000206	catalytic site [active]
434923000207	substrate binding site [chemical binding]; other site
434923000208	peroxidase; Provisional; Region: PRK15000
434923000209	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
434923000210	dimer interface [polypeptide binding]; other site
434923000211	decamer (pentamer of dimers) interface [polypeptide binding]; other site
434923000212	catalytic triad [active]
434923000213	peroxidatic and resolving cysteines [active]
434923000214	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
434923000215	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
434923000216	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
434923000217	dihydrodipicolinate reductase; Provisional; Region: PRK00048
434923000218	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
434923000219	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
434923000220	Predicted transcriptional regulator [Transcription]; Region: COG2944
434923000221	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923000222	non-specific DNA binding site [nucleotide binding]; other site
434923000223	salt bridge; other site
434923000224	sequence-specific DNA binding site [nucleotide binding]; other site
434923000225	Coxiella burnetii protein of unknown function (DUF807); Region: DUF807; pfam05660
434923000226	Coxiella burnetii protein of unknown function (DUF762); Region: DUF762; pfam05555
434923000227	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
434923000228	active site
434923000229	Coxiella burnetii protein of unknown function (DUF762); Region: DUF762; pfam05555
434923000230	Coxiella burnetii protein of unknown function (DUF807); Region: DUF807; pfam05660
434923000231	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
434923000232	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
434923000233	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
434923000234	Int/Topo IB signature motif; other site
434923000235	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
434923000236	GIY-YIG motif/motif A; other site
434923000237	putative active site [active]
434923000238	putative metal binding site [ion binding]; other site
434923000239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000240	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000241	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000242	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
434923000243	tetramer interface [polypeptide binding]; other site
434923000244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923000245	catalytic residue [active]
434923000246	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
434923000247	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
434923000248	tetramer interface [polypeptide binding]; other site
434923000249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923000250	catalytic residue [active]
434923000251	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
434923000252	lipoyl attachment site [posttranslational modification]; other site
434923000253	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
434923000254	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
434923000255	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
434923000256	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
434923000257	ring oligomerisation interface [polypeptide binding]; other site
434923000258	ATP/Mg binding site [chemical binding]; other site
434923000259	stacking interactions; other site
434923000260	hinge regions; other site
434923000261	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
434923000262	oligomerisation interface [polypeptide binding]; other site
434923000263	mobile loop; other site
434923000264	roof hairpin; other site
434923000265	aconitate hydratase; Validated; Region: PRK09277
434923000266	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
434923000267	substrate binding site [chemical binding]; other site
434923000268	ligand binding site [chemical binding]; other site
434923000269	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
434923000270	substrate binding site [chemical binding]; other site
434923000271	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
434923000272	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
434923000273	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
434923000274	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
434923000275	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
434923000276	DsbD alpha interface [polypeptide binding]; other site
434923000277	catalytic residues [active]
434923000278	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
434923000279	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
434923000280	carboxyltransferase (CT) interaction site; other site
434923000281	biotinylation site [posttranslational modification]; other site
434923000282	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
434923000283	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
434923000284	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
434923000285	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
434923000286	ornithine cyclodeaminase; Validated; Region: PRK07589
434923000287	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
434923000288	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
434923000289	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
434923000290	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
434923000291	phosphoserine phosphatase SerB; Region: serB; TIGR00338
434923000292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923000293	active site
434923000294	motif I; other site
434923000295	motif II; other site
434923000296	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
434923000297	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
434923000298	putative ligand binding site [chemical binding]; other site
434923000299	putative NAD binding site [chemical binding]; other site
434923000300	putative catalytic site [active]
434923000301	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
434923000302	L-serine binding site [chemical binding]; other site
434923000303	ACT domain interface; other site
434923000304	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
434923000305	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
434923000306	Walker A motif; other site
434923000307	ATP binding site [chemical binding]; other site
434923000308	Walker B motif; other site
434923000309	arginine finger; other site
434923000310	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
434923000311	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
434923000312	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
434923000313	dimerization interface [polypeptide binding]; other site
434923000314	putative ATP binding site [chemical binding]; other site
434923000315	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
434923000316	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
434923000317	active site
434923000318	substrate binding site [chemical binding]; other site
434923000319	cosubstrate binding site; other site
434923000320	catalytic site [active]
434923000321	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
434923000322	IHF dimer interface [polypeptide binding]; other site
434923000323	IHF - DNA interface [nucleotide binding]; other site
434923000324	Predicted methyltransferases [General function prediction only]; Region: COG0313
434923000325	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
434923000326	putative SAM binding site [chemical binding]; other site
434923000327	putative homodimer interface [polypeptide binding]; other site
434923000328	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
434923000329	putative ligand binding site [chemical binding]; other site
434923000330	hypothetical protein; Provisional; Region: PRK14684
434923000331	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
434923000332	dimer interface [polypeptide binding]; other site
434923000333	active site
434923000334	BON domain; Region: BON; pfam04972
434923000335	BON domain; Region: BON; pfam04972
434923000336	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
434923000337	Peptidase family M50; Region: Peptidase_M50; pfam02163
434923000338	active site
434923000339	putative substrate binding region [chemical binding]; other site
434923000340	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
434923000341	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
434923000342	C-terminal domain interface [polypeptide binding]; other site
434923000343	putative GSH binding site (G-site) [chemical binding]; other site
434923000344	dimer interface [polypeptide binding]; other site
434923000345	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
434923000346	dimer interface [polypeptide binding]; other site
434923000347	N-terminal domain interface [polypeptide binding]; other site
434923000348	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
434923000349	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
434923000350	23S rRNA interface [nucleotide binding]; other site
434923000351	L3 interface [polypeptide binding]; other site
434923000352	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
434923000353	IHF - DNA interface [nucleotide binding]; other site
434923000354	IHF dimer interface [polypeptide binding]; other site
434923000355	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
434923000356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923000357	putative substrate translocation pore; other site
434923000358	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
434923000359	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923000360	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923000361	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923000362	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
434923000363	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923000364	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923000365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000366	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000367	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000368	PAS fold; Region: PAS_4; pfam08448
434923000369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
434923000370	putative active site [active]
434923000371	heme pocket [chemical binding]; other site
434923000372	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923000373	dimer interface [polypeptide binding]; other site
434923000374	phosphorylation site [posttranslational modification]
434923000375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923000376	ATP binding site [chemical binding]; other site
434923000377	Mg2+ binding site [ion binding]; other site
434923000378	G-X-G motif; other site
434923000379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923000380	active site
434923000381	phosphorylation site [posttranslational modification]
434923000382	intermolecular recognition site; other site
434923000383	dimerization interface [polypeptide binding]; other site
434923000384	Hpt domain; Region: Hpt; pfam01627
434923000385	FAD dependent oxidoreductase; Region: DAO; pfam01266
434923000386	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
434923000387	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923000388	AAA domain; Region: AAA_14; pfam13173
434923000389	FeoC like transcriptional regulator; Region: FeoC; pfam09012
434923000390	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
434923000391	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
434923000392	G1 box; other site
434923000393	GTP/Mg2+ binding site [chemical binding]; other site
434923000394	Switch I region; other site
434923000395	G2 box; other site
434923000396	G3 box; other site
434923000397	Switch II region; other site
434923000398	G4 box; other site
434923000399	G5 box; other site
434923000400	Nucleoside recognition; Region: Gate; pfam07670
434923000401	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
434923000402	Nucleoside recognition; Region: Gate; pfam07670
434923000403	FeoA domain; Region: FeoA; pfam04023
434923000404	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
434923000405	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
434923000406	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
434923000407	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
434923000408	Walker A/P-loop; other site
434923000409	ATP binding site [chemical binding]; other site
434923000410	Q-loop/lid; other site
434923000411	ABC transporter signature motif; other site
434923000412	Walker B; other site
434923000413	D-loop; other site
434923000414	H-loop/switch region; other site
434923000415	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
434923000416	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
434923000417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
434923000418	dimer interface [polypeptide binding]; other site
434923000419	conserved gate region; other site
434923000420	putative PBP binding loops; other site
434923000421	ABC-ATPase subunit interface; other site
434923000422	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
434923000423	G1 box; other site
434923000424	GTP/Mg2+ binding site [chemical binding]; other site
434923000425	Switch I region; other site
434923000426	G2 box; other site
434923000427	G3 box; other site
434923000428	Switch II region; other site
434923000429	G4 box; other site
434923000430	G5 box; other site
434923000431	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
434923000432	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
434923000433	intersubunit interface [polypeptide binding]; other site
434923000434	active site
434923000435	zinc binding site [ion binding]; other site
434923000436	Na+ binding site [ion binding]; other site
434923000437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000438	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000439	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000440	pyruvate kinase; Provisional; Region: PRK05826
434923000441	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
434923000442	domain interfaces; other site
434923000443	active site
434923000444	Phosphoglycerate kinase; Region: PGK; pfam00162
434923000445	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
434923000446	substrate binding site [chemical binding]; other site
434923000447	hinge regions; other site
434923000448	ADP binding site [chemical binding]; other site
434923000449	catalytic site [active]
434923000450	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
434923000451	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
434923000452	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
434923000453	transketolase; Reviewed; Region: PRK12753
434923000454	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
434923000455	TPP-binding site [chemical binding]; other site
434923000456	dimer interface [polypeptide binding]; other site
434923000457	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
434923000458	PYR/PP interface [polypeptide binding]; other site
434923000459	dimer interface [polypeptide binding]; other site
434923000460	TPP binding site [chemical binding]; other site
434923000461	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
434923000462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000463	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000464	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000465	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
434923000466	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
434923000467	glutaminase active site [active]
434923000468	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
434923000469	dimer interface [polypeptide binding]; other site
434923000470	active site
434923000471	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
434923000472	dimer interface [polypeptide binding]; other site
434923000473	active site
434923000474	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
434923000475	DNA polymerase I; Provisional; Region: PRK05755
434923000476	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
434923000477	active site
434923000478	metal binding site 1 [ion binding]; metal-binding site
434923000479	putative 5' ssDNA interaction site; other site
434923000480	metal binding site 3; metal-binding site
434923000481	metal binding site 2 [ion binding]; metal-binding site
434923000482	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
434923000483	putative DNA binding site [nucleotide binding]; other site
434923000484	putative metal binding site [ion binding]; other site
434923000485	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
434923000486	active site
434923000487	catalytic site [active]
434923000488	substrate binding site [chemical binding]; other site
434923000489	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
434923000490	active site
434923000491	DNA binding site [nucleotide binding]
434923000492	catalytic site [active]
434923000493	amino acid transporter; Region: 2A0306; TIGR00909
434923000494	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
434923000495	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
434923000496	K+ potassium transporter; Region: K_trans; cl15781
434923000497	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
434923000498	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
434923000499	Coenzyme A binding pocket [chemical binding]; other site
434923000500	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
434923000501	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
434923000502	FtsX-like permease family; Region: FtsX; pfam02687
434923000503	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
434923000504	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
434923000505	Walker A/P-loop; other site
434923000506	ATP binding site [chemical binding]; other site
434923000507	Q-loop/lid; other site
434923000508	ABC transporter signature motif; other site
434923000509	Walker B; other site
434923000510	D-loop; other site
434923000511	H-loop/switch region; other site
434923000512	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
434923000513	HlyD family secretion protein; Region: HlyD_3; pfam13437
434923000514	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
434923000515	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
434923000516	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
434923000517	ligand binding site [chemical binding]; other site
434923000518	NAD binding site [chemical binding]; other site
434923000519	catalytic site [active]
434923000520	homodimer interface [polypeptide binding]; other site
434923000521	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
434923000522	primosome assembly protein PriA; Validated; Region: PRK05580
434923000523	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
434923000524	ATP binding site [chemical binding]; other site
434923000525	putative Mg++ binding site [ion binding]; other site
434923000526	helicase superfamily c-terminal domain; Region: HELICc; smart00490
434923000527	elongation factor P; Validated; Region: PRK00529
434923000528	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
434923000529	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
434923000530	RNA binding site [nucleotide binding]; other site
434923000531	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
434923000532	RNA binding site [nucleotide binding]; other site
434923000533	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
434923000534	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
434923000535	motif 1; other site
434923000536	dimer interface [polypeptide binding]; other site
434923000537	active site
434923000538	motif 2; other site
434923000539	motif 3; other site
434923000540	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
434923000541	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
434923000542	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
434923000543	E-class dimer interface [polypeptide binding]; other site
434923000544	P-class dimer interface [polypeptide binding]; other site
434923000545	active site
434923000546	Cu2+ binding site [ion binding]; other site
434923000547	Zn2+ binding site [ion binding]; other site
434923000548	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
434923000549	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
434923000550	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
434923000551	active site
434923000552	NTP binding site [chemical binding]; other site
434923000553	metal binding triad [ion binding]; metal-binding site
434923000554	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
434923000555	Uncharacterized conserved protein [Function unknown]; Region: COG1565
434923000556	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
434923000557	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
434923000558	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
434923000559	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
434923000560	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
434923000561	active site
434923000562	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
434923000563	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
434923000564	active site
434923000565	GIY-YIG motif/motif A; other site
434923000566	catalytic site [active]
434923000567	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
434923000568	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
434923000569	substrate binding site; other site
434923000570	tetramer interface; other site
434923000571	hypothetical protein; Provisional; Region: PRK07208
434923000572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
434923000573	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
434923000574	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
434923000575	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
434923000576	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
434923000577	extended (e) SDRs; Region: SDR_e; cd08946
434923000578	NAD(P) binding site [chemical binding]; other site
434923000579	active site
434923000580	substrate binding site [chemical binding]; other site
434923000581	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
434923000582	hydroxyglutarate oxidase; Provisional; Region: PRK11728
434923000583	Predicted dehydrogenase [General function prediction only]; Region: COG0579
434923000584	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
434923000585	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
434923000586	5S rRNA interface [nucleotide binding]; other site
434923000587	CTC domain interface [polypeptide binding]; other site
434923000588	L16 interface [polypeptide binding]; other site
434923000589	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
434923000590	putative active site [active]
434923000591	catalytic residue [active]
434923000592	GTP-binding protein YchF; Reviewed; Region: PRK09601
434923000593	YchF GTPase; Region: YchF; cd01900
434923000594	G1 box; other site
434923000595	GTP/Mg2+ binding site [chemical binding]; other site
434923000596	Switch I region; other site
434923000597	G2 box; other site
434923000598	Switch II region; other site
434923000599	G3 box; other site
434923000600	G4 box; other site
434923000601	G5 box; other site
434923000602	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
434923000603	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
434923000604	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
434923000605	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
434923000606	Predicted membrane protein [Function unknown]; Region: COG2246
434923000607	GtrA-like protein; Region: GtrA; pfam04138
434923000608	TPR repeat; Region: TPR_11; pfam13414
434923000609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923000610	binding surface
434923000611	TPR motif; other site
434923000612	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
434923000613	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
434923000614	substrate binding site [chemical binding]; other site
434923000615	oxyanion hole (OAH) forming residues; other site
434923000616	trimer interface [polypeptide binding]; other site
434923000617	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
434923000618	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
434923000619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
434923000620	dimer interface [polypeptide binding]; other site
434923000621	conserved gate region; other site
434923000622	putative PBP binding loops; other site
434923000623	ABC-ATPase subunit interface; other site
434923000624	Radical SAM superfamily; Region: Radical_SAM; pfam04055
434923000625	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923000626	FeS/SAM binding site; other site
434923000627	Bacterial PH domain; Region: DUF304; pfam03703
434923000628	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
434923000629	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
434923000630	CAP-like domain; other site
434923000631	active site
434923000632	primary dimer interface [polypeptide binding]; other site
434923000633	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
434923000634	diiron binding motif [ion binding]; other site
434923000635	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
434923000636	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
434923000637	glutamine binding [chemical binding]; other site
434923000638	catalytic triad [active]
434923000639	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
434923000640	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
434923000641	substrate binding site [chemical binding]; other site
434923000642	hexamer interface [polypeptide binding]; other site
434923000643	metal binding site [ion binding]; metal-binding site
434923000644	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
434923000645	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
434923000646	putative metal binding site [ion binding]; other site
434923000647	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
434923000648	HSP70 interaction site [polypeptide binding]; other site
434923000649	Glutamate-cysteine ligase; Region: GshA; pfam08886
434923000650	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
434923000651	glutathione synthetase; Provisional; Region: PRK05246
434923000652	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
434923000653	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
434923000654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923000655	S-adenosylmethionine binding site [chemical binding]; other site
434923000656	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923000657	Walker A motif; other site
434923000658	ATP binding site [chemical binding]; other site
434923000659	Walker B motif; other site
434923000660	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
434923000661	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
434923000662	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
434923000663	active site
434923000664	catalytic residues [active]
434923000665	metal binding site [ion binding]; metal-binding site
434923000666	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
434923000667	Rubredoxin [Energy production and conversion]; Region: COG1773
434923000668	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
434923000669	iron binding site [ion binding]; other site
434923000670	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
434923000671	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
434923000672	inhibitor-cofactor binding pocket; inhibition site
434923000673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923000674	catalytic residue [active]
434923000675	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
434923000676	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
434923000677	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
434923000678	Transglycosylase; Region: Transgly; pfam00912
434923000679	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
434923000680	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
434923000681	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
434923000682	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
434923000683	shikimate kinase; Reviewed; Region: aroK; PRK00131
434923000684	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
434923000685	ADP binding site [chemical binding]; other site
434923000686	magnesium binding site [ion binding]; other site
434923000687	putative shikimate binding site; other site
434923000688	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
434923000689	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
434923000690	active site
434923000691	dimer interface [polypeptide binding]; other site
434923000692	metal binding site [ion binding]; metal-binding site
434923000693	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000694	H+ Antiporter protein; Region: 2A0121; TIGR00900
434923000695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923000696	putative substrate translocation pore; other site
434923000697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000698	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000699	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000700	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
434923000701	Protein of unknown function (DUF497); Region: DUF497; pfam04365
434923000702	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
434923000703	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
434923000704	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
434923000705	shikimate binding site; other site
434923000706	NAD(P) binding site [chemical binding]; other site
434923000707	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
434923000708	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
434923000709	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
434923000710	purine nucleoside phosphorylase; Provisional; Region: PRK08202
434923000711	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
434923000712	intersubunit interface [polypeptide binding]; other site
434923000713	active site
434923000714	catalytic residue [active]
434923000715	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
434923000716	30S subunit binding site; other site
434923000717	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
434923000718	DNA-binding site [nucleotide binding]; DNA binding site
434923000719	RNA-binding motif; other site
434923000720	carbon storage regulator; Provisional; Region: PRK01712
434923000721	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
434923000722	tetramer (dimer of dimers) interface [polypeptide binding]; other site
434923000723	active site
434923000724	dimer interface [polypeptide binding]; other site
434923000725	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
434923000726	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
434923000727	putative acyl-acceptor binding pocket; other site
434923000728	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
434923000729	FAD binding domain; Region: FAD_binding_4; pfam01565
434923000730	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
434923000731	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
434923000732	putative acyl-acceptor binding pocket; other site
434923000733	helix swapped region; other site
434923000734	Hydroxymethylglutaryl-coenzyme A reductase; Region: HMG-CoA_red; pfam00368
434923000735	homodimer interface [polypeptide binding]; other site
434923000736	catalytic residues [active]
434923000737	substrate binding pocket [chemical binding]; other site
434923000738	NADH/NADPH cofactor binding site [chemical binding]; other site
434923000739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923000740	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000741	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923000742	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
434923000743	acyl carrier protein; Provisional; Region: acpP; PRK00982
434923000744	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
434923000745	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
434923000746	dimer interface [polypeptide binding]; other site
434923000747	active site
434923000748	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
434923000749	active site 2 [active]
434923000750	active site 1 [active]
434923000751	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
434923000752	active site 2 [active]
434923000753	dimer interface [polypeptide binding]; other site
434923000754	active site 1 [active]
434923000755	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
434923000756	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
434923000757	dimer interface [polypeptide binding]; other site
434923000758	active site
434923000759	CoA binding pocket [chemical binding]; other site
434923000760	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
434923000761	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
434923000762	active site
434923000763	Zn binding site [ion binding]; other site
434923000764	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000765	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000766	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000767	RNA methyltransferase, RsmE family; Region: TIGR00046
434923000768	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
434923000769	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
434923000770	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
434923000771	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
434923000772	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
434923000773	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
434923000774	ligand binding site [chemical binding]; other site
434923000775	homodimer interface [polypeptide binding]; other site
434923000776	NAD(P) binding site [chemical binding]; other site
434923000777	trimer interface B [polypeptide binding]; other site
434923000778	trimer interface A [polypeptide binding]; other site
434923000779	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
434923000780	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
434923000781	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
434923000782	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
434923000783	ABC transporter; Region: ABC_tran_2; pfam12848
434923000784	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
434923000785	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
434923000786	Nuclease-related domain; Region: NERD; pfam08378
434923000787	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
434923000788	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923000789	AAA domain; Region: AAA_14; pfam13173
434923000790	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
434923000791	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
434923000792	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
434923000793	minor groove reading motif; other site
434923000794	helix-hairpin-helix signature motif; other site
434923000795	substrate binding pocket [chemical binding]; other site
434923000796	active site
434923000797	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
434923000798	ferredoxin; Provisional; Region: PRK08764
434923000799	Putative Fe-S cluster; Region: FeS; pfam04060
434923000800	4Fe-4S binding domain; Region: Fer4; pfam00037
434923000801	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
434923000802	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
434923000803	active site
434923000804	HIGH motif; other site
434923000805	KMSKS motif; other site
434923000806	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
434923000807	tRNA binding surface [nucleotide binding]; other site
434923000808	anticodon binding site; other site
434923000809	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
434923000810	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923000811	non-specific DNA binding site [nucleotide binding]; other site
434923000812	salt bridge; other site
434923000813	sequence-specific DNA binding site [nucleotide binding]; other site
434923000814	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
434923000815	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
434923000816	Walker A motif; other site
434923000817	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
434923000818	trimer interface [polypeptide binding]; other site
434923000819	active site
434923000820	CTP synthetase; Validated; Region: pyrG; PRK05380
434923000821	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
434923000822	Catalytic site [active]
434923000823	active site
434923000824	UTP binding site [chemical binding]; other site
434923000825	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
434923000826	active site
434923000827	putative oxyanion hole; other site
434923000828	catalytic triad [active]
434923000829	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
434923000830	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
434923000831	Hemerythrin-like domain; Region: Hr-like; cd12108
434923000832	Fe binding site [ion binding]; other site
434923000833	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
434923000834	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
434923000835	enolase; Provisional; Region: eno; PRK00077
434923000836	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
434923000837	dimer interface [polypeptide binding]; other site
434923000838	metal binding site [ion binding]; metal-binding site
434923000839	substrate binding pocket [chemical binding]; other site
434923000840	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
434923000841	Septum formation initiator; Region: DivIC; cl17659
434923000842	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
434923000843	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
434923000844	Peptidase family M23; Region: Peptidase_M23; pfam01551
434923000845	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
434923000846	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
434923000847	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
434923000848	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
434923000849	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
434923000850	DNA binding residues [nucleotide binding]
434923000851	Zinc-finger domain; Region: zf-CHCC; cl01821
434923000852	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
434923000853	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
434923000854	putative active site [active]
434923000855	Uncharacterized conserved protein [Function unknown]; Region: COG5495
434923000856	Rossmann-like domain; Region: Rossmann-like; pfam10727
434923000857	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
434923000858	O-Antigen ligase; Region: Wzy_C; pfam04932
434923000859	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
434923000860	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
434923000861	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
434923000862	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
434923000863	putative metal binding site; other site
434923000864	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000865	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000866	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000867	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
434923000868	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
434923000869	putative ribose interaction site [chemical binding]; other site
434923000870	putative ADP binding site [chemical binding]; other site
434923000871	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
434923000872	active site
434923000873	nucleotide binding site [chemical binding]; other site
434923000874	HIGH motif; other site
434923000875	KMSKS motif; other site
434923000876	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
434923000877	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000878	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000879	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000880	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
434923000881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000882	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000883	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000884	BCCT family transporter; Region: BCCT; cl00569
434923000885	BCCT family transporter; Region: BCCT; cl00569
434923000886	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
434923000887	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923000888	Walker A motif; other site
434923000889	ATP binding site [chemical binding]; other site
434923000890	Walker B motif; other site
434923000891	Protein of unknown function (DUF3773); Region: DUF3773; pfam12608
434923000892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000893	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000894	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000895	AAA domain; Region: AAA_22; pfam13401
434923000896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923000897	Walker A motif; other site
434923000898	ATP binding site [chemical binding]; other site
434923000899	Walker B motif; other site
434923000900	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
434923000901	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
434923000902	Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; cl09711
434923000903	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923000904	Walker A motif; other site
434923000905	ATP binding site [chemical binding]; other site
434923000906	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
434923000907	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
434923000908	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
434923000909	ligand binding site [chemical binding]; other site
434923000910	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
434923000911	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
434923000912	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
434923000913	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
434923000914	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
434923000915	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
434923000916	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
434923000917	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
434923000918	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
434923000919	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
434923000920	HNH nucleases; Region: HNHc; smart00507
434923000921	AAA-like domain; Region: AAA_10; pfam12846
434923000922	DivIVA protein; Region: DivIVA; pfam05103
434923000923	Predicted deacylase [General function prediction only]; Region: COG3608
434923000924	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
434923000925	putative active site [active]
434923000926	Zn binding site [ion binding]; other site
434923000927	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
434923000928	RimK-like ATP-grasp domain; Region: RimK; pfam08443
434923000929	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
434923000930	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
434923000931	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
434923000932	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
434923000933	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
434923000934	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
434923000935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
434923000936	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
434923000937	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
434923000938	DNA binding residues [nucleotide binding]
434923000939	DNA primase; Validated; Region: dnaG; PRK05667
434923000940	CHC2 zinc finger; Region: zf-CHC2; pfam01807
434923000941	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
434923000942	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
434923000943	active site
434923000944	metal binding site [ion binding]; metal-binding site
434923000945	interdomain interaction site; other site
434923000946	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
434923000947	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
434923000948	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
434923000949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000950	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000951	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000952	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
434923000953	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
434923000954	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
434923000955	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
434923000956	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
434923000957	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
434923000958	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
434923000959	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
434923000960	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
434923000961	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
434923000962	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
434923000963	Predicted ATPase [General function prediction only]; Region: COG1485
434923000964	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923000965	Walker A motif; other site
434923000966	ATP binding site [chemical binding]; other site
434923000967	Walker B motif; other site
434923000968	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
434923000969	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
434923000970	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
434923000971	L,D-transpeptidase; Provisional; Region: PRK10190
434923000972	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
434923000973	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923000974	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
434923000975	TolR protein; Region: tolR; TIGR02801
434923000976	TolQ protein; Region: tolQ; TIGR02796
434923000977	putative MFS family transporter protein; Provisional; Region: PRK03633
434923000978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923000979	putative substrate translocation pore; other site
434923000980	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923000981	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923000982	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923000983	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
434923000984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923000985	Walker A motif; other site
434923000986	ATP binding site [chemical binding]; other site
434923000987	Walker B motif; other site
434923000988	arginine finger; other site
434923000989	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
434923000990	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
434923000991	RuvA N terminal domain; Region: RuvA_N; pfam01330
434923000992	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
434923000993	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
434923000994	active site
434923000995	putative DNA-binding cleft [nucleotide binding]; other site
434923000996	dimer interface [polypeptide binding]; other site
434923000997	hypothetical protein; Validated; Region: PRK00110
434923000998	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
434923000999	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
434923001000	dimer interface [polypeptide binding]; other site
434923001001	anticodon binding site; other site
434923001002	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
434923001003	homodimer interface [polypeptide binding]; other site
434923001004	motif 1; other site
434923001005	active site
434923001006	motif 2; other site
434923001007	GAD domain; Region: GAD; pfam02938
434923001008	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
434923001009	active site
434923001010	motif 3; other site
434923001011	Uncharacterized conserved protein [Function unknown]; Region: COG2928
434923001012	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
434923001013	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
434923001014	Transposase [DNA replication, recombination, and repair]; Region: COG5433
434923001015	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
434923001016	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
434923001017	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
434923001018	dimer interface [polypeptide binding]; other site
434923001019	putative radical transfer pathway; other site
434923001020	diiron center [ion binding]; other site
434923001021	tyrosyl radical; other site
434923001022	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
434923001023	ATP cone domain; Region: ATP-cone; pfam03477
434923001024	Class I ribonucleotide reductase; Region: RNR_I; cd01679
434923001025	active site
434923001026	dimer interface [polypeptide binding]; other site
434923001027	catalytic residues [active]
434923001028	effector binding site; other site
434923001029	R2 peptide binding site; other site
434923001030	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
434923001031	putative active site [active]
434923001032	Ap4A binding site [chemical binding]; other site
434923001033	nudix motif; other site
434923001034	putative metal binding site [ion binding]; other site
434923001035	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
434923001036	GAF domain; Region: GAF; pfam01590
434923001037	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
434923001038	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
434923001039	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
434923001040	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
434923001041	thymidylate synthase; Reviewed; Region: thyA; PRK01827
434923001042	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
434923001043	dimerization interface [polypeptide binding]; other site
434923001044	active site
434923001045	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
434923001046	aromatic amino acid transport protein; Region: araaP; TIGR00837
434923001047	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
434923001048	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
434923001049	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
434923001050	protein binding site [polypeptide binding]; other site
434923001051	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
434923001052	Catalytic dyad [active]
434923001053	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
434923001054	Peptidase family M23; Region: Peptidase_M23; pfam01551
434923001055	phosphoglyceromutase; Provisional; Region: PRK05434
434923001056	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
434923001057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001058	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001059	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001060	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
434923001061	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
434923001062	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
434923001063	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
434923001064	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
434923001065	active site residue [active]
434923001066	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
434923001067	GSH binding site [chemical binding]; other site
434923001068	catalytic residues [active]
434923001069	preprotein translocase subunit SecB; Validated; Region: PRK05751
434923001070	SecA binding site; other site
434923001071	Preprotein binding site; other site
434923001072	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
434923001073	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
434923001074	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
434923001075	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
434923001076	Transposase [DNA replication, recombination, and repair]; Region: COG5421
434923001077	classical (c) SDRs; Region: SDR_c; cd05233
434923001078	NAD(P) binding site [chemical binding]; other site
434923001079	active site
434923001080	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
434923001081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923001082	NAD(P) binding site [chemical binding]; other site
434923001083	active site
434923001084	rhodanese superfamily protein; Provisional; Region: PRK05320
434923001085	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
434923001086	active site residue [active]
434923001087	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
434923001088	ZIP Zinc transporter; Region: Zip; pfam02535
434923001089	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
434923001090	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
434923001091	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
434923001092	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
434923001093	Ligand Binding Site [chemical binding]; other site
434923001094	TilS substrate binding domain; Region: TilS; pfam09179
434923001095	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
434923001096	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923001097	AAA domain; Region: AAA_14; pfam13173
434923001098	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
434923001099	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
434923001100	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
434923001101	metal-binding site [ion binding]
434923001102	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
434923001103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923001104	motif II; other site
434923001105	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
434923001106	active site
434923001107	GTP-binding protein LepA; Provisional; Region: PRK05433
434923001108	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
434923001109	G1 box; other site
434923001110	putative GEF interaction site [polypeptide binding]; other site
434923001111	GTP/Mg2+ binding site [chemical binding]; other site
434923001112	Switch I region; other site
434923001113	G2 box; other site
434923001114	G3 box; other site
434923001115	Switch II region; other site
434923001116	G4 box; other site
434923001117	G5 box; other site
434923001118	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
434923001119	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
434923001120	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
434923001121	signal peptidase I; Provisional; Region: PRK10861
434923001122	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
434923001123	Catalytic site [active]
434923001124	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
434923001125	ribonuclease III; Reviewed; Region: rnc; PRK00102
434923001126	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
434923001127	dimerization interface [polypeptide binding]; other site
434923001128	active site
434923001129	metal binding site [ion binding]; metal-binding site
434923001130	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
434923001131	dsRNA binding site [nucleotide binding]; other site
434923001132	GTPase Era; Reviewed; Region: era; PRK00089
434923001133	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
434923001134	G1 box; other site
434923001135	GTP/Mg2+ binding site [chemical binding]; other site
434923001136	Switch I region; other site
434923001137	G2 box; other site
434923001138	Switch II region; other site
434923001139	G3 box; other site
434923001140	G4 box; other site
434923001141	G5 box; other site
434923001142	KH domain; Region: KH_2; pfam07650
434923001143	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
434923001144	Recombination protein O N terminal; Region: RecO_N; pfam11967
434923001145	Recombination protein O C terminal; Region: RecO_C; pfam02565
434923001146	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
434923001147	active site
434923001148	hydrophilic channel; other site
434923001149	dimerization interface [polypeptide binding]; other site
434923001150	catalytic residues [active]
434923001151	active site lid [active]
434923001152	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
434923001153	Transposase [DNA replication, recombination, and repair]; Region: COG5433
434923001154	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
434923001155	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
434923001156	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
434923001157	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
434923001158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923001159	sequence-specific DNA binding site [nucleotide binding]; other site
434923001160	salt bridge; other site
434923001161	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
434923001162	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
434923001163	putative active site [active]
434923001164	putative metal binding site [ion binding]; other site
434923001165	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
434923001166	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
434923001167	HIGH motif; other site
434923001168	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
434923001169	active site
434923001170	KMSKS motif; other site
434923001171	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
434923001172	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
434923001173	active site
434923001174	HIGH motif; other site
434923001175	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
434923001176	KMSKS motif; other site
434923001177	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
434923001178	tRNA binding surface [nucleotide binding]; other site
434923001179	anticodon binding site; other site
434923001180	Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; Region: CYCLIN; cl00050
434923001181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923001182	D-galactonate transporter; Region: 2A0114; TIGR00893
434923001183	putative substrate translocation pore; other site
434923001184	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
434923001185	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
434923001186	dimer interface [polypeptide binding]; other site
434923001187	active site residues [active]
434923001188	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
434923001189	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
434923001190	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
434923001191	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
434923001192	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
434923001193	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
434923001194	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
434923001195	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001196	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001197	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001198	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
434923001199	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
434923001200	dimer interface [polypeptide binding]; other site
434923001201	decamer (pentamer of dimers) interface [polypeptide binding]; other site
434923001202	catalytic triad [active]
434923001203	peroxidatic and resolving cysteines [active]
434923001204	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
434923001205	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
434923001206	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
434923001207	dimerization interface [polypeptide binding]; other site
434923001208	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
434923001209	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
434923001210	GatB domain; Region: GatB_Yqey; smart00845
434923001211	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
434923001212	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
434923001213	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
434923001214	rod shape-determining protein MreB; Provisional; Region: PRK13927
434923001215	MreB and similar proteins; Region: MreB_like; cd10225
434923001216	nucleotide binding site [chemical binding]; other site
434923001217	Mg binding site [ion binding]; other site
434923001218	putative protofilament interaction site [polypeptide binding]; other site
434923001219	RodZ interaction site [polypeptide binding]; other site
434923001220	rod shape-determining protein MreC; Provisional; Region: PRK13922
434923001221	rod shape-determining protein MreC; Region: MreC; pfam04085
434923001222	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
434923001223	Protein of unknown function; Region: DUF3971; pfam13116
434923001224	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
434923001225	protease TldD; Provisional; Region: tldD; PRK10735
434923001226	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
434923001227	EVE domain; Region: EVE; cl00728
434923001228	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
434923001229	IHF dimer interface [polypeptide binding]; other site
434923001230	IHF - DNA interface [nucleotide binding]; other site
434923001231	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923001232	AAA domain; Region: AAA_14; pfam13173
434923001233	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
434923001234	Sel1-like repeats; Region: SEL1; smart00671
434923001235	Sel1-like repeats; Region: SEL1; smart00671
434923001236	SurA N-terminal domain; Region: SurA_N_3; cl07813
434923001237	triosephosphate isomerase; Provisional; Region: PRK14567
434923001238	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
434923001239	substrate binding site [chemical binding]; other site
434923001240	dimer interface [polypeptide binding]; other site
434923001241	catalytic triad [active]
434923001242	Preprotein translocase SecG subunit; Region: SecG; pfam03840
434923001243	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
434923001244	NADH dehydrogenase subunit B; Validated; Region: PRK06411
434923001245	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
434923001246	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
434923001247	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
434923001248	NADH dehydrogenase subunit D; Validated; Region: PRK06075
434923001249	NADH dehydrogenase subunit E; Validated; Region: PRK07539
434923001250	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
434923001251	putative dimer interface [polypeptide binding]; other site
434923001252	[2Fe-2S] cluster binding site [ion binding]; other site
434923001253	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
434923001254	SLBB domain; Region: SLBB; pfam10531
434923001255	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
434923001256	NADH dehydrogenase subunit G; Validated; Region: PRK09129
434923001257	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
434923001258	catalytic loop [active]
434923001259	iron binding site [ion binding]; other site
434923001260	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
434923001261	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
434923001262	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
434923001263	molybdopterin cofactor binding site; other site
434923001264	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
434923001265	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
434923001266	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
434923001267	4Fe-4S binding domain; Region: Fer4; pfam00037
434923001268	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
434923001269	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
434923001270	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
434923001271	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
434923001272	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
434923001273	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
434923001274	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
434923001275	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
434923001276	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
434923001277	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
434923001278	ribosome maturation protein RimP; Reviewed; Region: PRK00092
434923001279	Sm and related proteins; Region: Sm_like; cl00259
434923001280	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
434923001281	putative oligomer interface [polypeptide binding]; other site
434923001282	putative RNA binding site [nucleotide binding]; other site
434923001283	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
434923001284	NusA N-terminal domain; Region: NusA_N; pfam08529
434923001285	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
434923001286	RNA binding site [nucleotide binding]; other site
434923001287	homodimer interface [polypeptide binding]; other site
434923001288	NusA-like KH domain; Region: KH_5; pfam13184
434923001289	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
434923001290	G-X-X-G motif; other site
434923001291	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
434923001292	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
434923001293	translation initiation factor IF-2; Validated; Region: infB; PRK05306
434923001294	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
434923001295	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
434923001296	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
434923001297	G1 box; other site
434923001298	putative GEF interaction site [polypeptide binding]; other site
434923001299	GTP/Mg2+ binding site [chemical binding]; other site
434923001300	Switch I region; other site
434923001301	G2 box; other site
434923001302	G3 box; other site
434923001303	Switch II region; other site
434923001304	G4 box; other site
434923001305	G5 box; other site
434923001306	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
434923001307	Translation-initiation factor 2; Region: IF-2; pfam11987
434923001308	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
434923001309	ribosome-binding factor A; Provisional; Region: PRK13817
434923001310	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
434923001311	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
434923001312	RNA binding site [nucleotide binding]; other site
434923001313	active site
434923001314	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
434923001315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001316	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001317	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001318	Protein of unknown function (DUF962); Region: DUF962; cl01879
434923001319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001320	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001321	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
434923001322	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
434923001323	dimer interface [polypeptide binding]; other site
434923001324	active site
434923001325	Schiff base residues; other site
434923001326	DNA repair protein RadA; Provisional; Region: PRK11823
434923001327	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923001328	Walker A motif; other site
434923001329	ATP binding site [chemical binding]; other site
434923001330	Walker B motif; other site
434923001331	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
434923001332	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
434923001333	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
434923001334	dimer interface [polypeptide binding]; other site
434923001335	active site
434923001336	glycine-pyridoxal phosphate binding site [chemical binding]; other site
434923001337	folate binding site [chemical binding]; other site
434923001338	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
434923001339	ATP cone domain; Region: ATP-cone; pfam03477
434923001340	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
434923001341	putative RNA binding site [nucleotide binding]; other site
434923001342	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923001343	non-specific DNA binding site [nucleotide binding]; other site
434923001344	salt bridge; other site
434923001345	sequence-specific DNA binding site [nucleotide binding]; other site
434923001346	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
434923001347	Catalytic site [active]
434923001348	thiamine monophosphate kinase; Provisional; Region: PRK05731
434923001349	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
434923001350	ATP binding site [chemical binding]; other site
434923001351	dimerization interface [polypeptide binding]; other site
434923001352	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
434923001353	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
434923001354	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
434923001355	dimer interface [polypeptide binding]; other site
434923001356	active site
434923001357	citrylCoA binding site [chemical binding]; other site
434923001358	NADH binding [chemical binding]; other site
434923001359	cationic pore residues; other site
434923001360	oxalacetate/citrate binding site [chemical binding]; other site
434923001361	coenzyme A binding site [chemical binding]; other site
434923001362	catalytic triad [active]
434923001363	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
434923001364	Iron-sulfur protein interface; other site
434923001365	proximal quinone binding site [chemical binding]; other site
434923001366	SdhD (CybS) interface [polypeptide binding]; other site
434923001367	proximal heme binding site [chemical binding]; other site
434923001368	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
434923001369	SdhC subunit interface [polypeptide binding]; other site
434923001370	proximal heme binding site [chemical binding]; other site
434923001371	cardiolipin binding site; other site
434923001372	Iron-sulfur protein interface; other site
434923001373	proximal quinone binding site [chemical binding]; other site
434923001374	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
434923001375	L-aspartate oxidase; Provisional; Region: PRK06175
434923001376	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
434923001377	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
434923001378	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
434923001379	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
434923001380	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
434923001381	TPP-binding site [chemical binding]; other site
434923001382	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
434923001383	dimer interface [polypeptide binding]; other site
434923001384	PYR/PP interface [polypeptide binding]; other site
434923001385	TPP binding site [chemical binding]; other site
434923001386	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
434923001387	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
434923001388	E3 interaction surface; other site
434923001389	lipoyl attachment site [posttranslational modification]; other site
434923001390	e3 binding domain; Region: E3_binding; pfam02817
434923001391	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
434923001392	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
434923001393	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
434923001394	CoA-ligase; Region: Ligase_CoA; pfam00549
434923001395	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
434923001396	CoA binding domain; Region: CoA_binding; pfam02629
434923001397	CoA-ligase; Region: Ligase_CoA; pfam00549
434923001398	GtrA-like protein; Region: GtrA; pfam04138
434923001399	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923001400	Condensation domain; Region: Condensation; pfam00668
434923001401	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
434923001402	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
434923001403	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
434923001404	acyl-activating enzyme (AAE) consensus motif; other site
434923001405	AMP binding site [chemical binding]; other site
434923001406	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
434923001407	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
434923001408	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
434923001409	catalytic residue [active]
434923001410	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
434923001411	active site
434923001412	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
434923001413	rRNA interaction site [nucleotide binding]; other site
434923001414	S8 interaction site; other site
434923001415	putative laminin-1 binding site; other site
434923001416	elongation factor Ts; Provisional; Region: tsf; PRK09377
434923001417	UBA/TS-N domain; Region: UBA; pfam00627
434923001418	Elongation factor TS; Region: EF_TS; pfam00889
434923001419	Elongation factor TS; Region: EF_TS; pfam00889
434923001420	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
434923001421	putative nucleotide binding site [chemical binding]; other site
434923001422	uridine monophosphate binding site [chemical binding]; other site
434923001423	homohexameric interface [polypeptide binding]; other site
434923001424	ribosome recycling factor; Reviewed; Region: frr; PRK00083
434923001425	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
434923001426	hinge region; other site
434923001427	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
434923001428	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
434923001429	catalytic residue [active]
434923001430	putative FPP diphosphate  binding site; other site
434923001431	putative FPP binding hydrophobic cleft; other site
434923001432	dimer interface [polypeptide binding]; other site
434923001433	putative IPP diphosphate binding site; other site
434923001434	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
434923001435	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
434923001436	Predicted membrane protein [Function unknown]; Region: COG2259
434923001437	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
434923001438	active site
434923001439	substrate binding site [chemical binding]; other site
434923001440	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
434923001441	activation loop (A-loop); other site
434923001442	similar to hypothetical protein
434923001443	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
434923001444	HD domain; Region: HD_4; pfam13328
434923001445	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
434923001446	synthetase active site [active]
434923001447	NTP binding site [chemical binding]; other site
434923001448	metal binding site [ion binding]; metal-binding site
434923001449	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
434923001450	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
434923001451	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
434923001452	nucleoside/Zn binding site; other site
434923001453	dimer interface [polypeptide binding]; other site
434923001454	catalytic motif [active]
434923001455	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
434923001456	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
434923001457	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
434923001458	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001459	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001460	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001461	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
434923001462	Glycoprotease family; Region: Peptidase_M22; pfam00814
434923001463	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001464	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001465	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001466	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001467	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001468	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001469	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923001470	exonuclease I; Provisional; Region: sbcB; PRK11779
434923001471	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
434923001472	active site
434923001473	catalytic site [active]
434923001474	substrate binding site [chemical binding]; other site
434923001475	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
434923001476	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
434923001477	Cation efflux family; Region: Cation_efflux; pfam01545
434923001478	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
434923001479	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
434923001480	putative DNA binding site [nucleotide binding]; other site
434923001481	putative Zn2+ binding site [ion binding]; other site
434923001482	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
434923001483	putative ABC transporter; Region: ycf24; CHL00085
434923001484	FeS assembly ATPase SufC; Region: sufC; TIGR01978
434923001485	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
434923001486	Walker A/P-loop; other site
434923001487	ATP binding site [chemical binding]; other site
434923001488	Q-loop/lid; other site
434923001489	ABC transporter signature motif; other site
434923001490	Walker B; other site
434923001491	D-loop; other site
434923001492	H-loop/switch region; other site
434923001493	FeS assembly protein SufD; Region: sufD; TIGR01981
434923001494	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
434923001495	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
434923001496	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
434923001497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
434923001498	catalytic residue [active]
434923001499	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
434923001500	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
434923001501	trimerization site [polypeptide binding]; other site
434923001502	active site
434923001503	FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997
434923001504	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
434923001505	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
434923001506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923001507	S-adenosylmethionine binding site [chemical binding]; other site
434923001508	FtsH Extracellular; Region: FtsH_ext; pfam06480
434923001509	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
434923001510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923001511	Walker A motif; other site
434923001512	ATP binding site [chemical binding]; other site
434923001513	Walker B motif; other site
434923001514	arginine finger; other site
434923001515	Peptidase family M41; Region: Peptidase_M41; pfam01434
434923001516	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
434923001517	dihydropteroate synthase; Region: DHPS; TIGR01496
434923001518	substrate binding pocket [chemical binding]; other site
434923001519	dimer interface [polypeptide binding]; other site
434923001520	inhibitor binding site; inhibition site
434923001521	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
434923001522	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
434923001523	active site
434923001524	substrate binding site [chemical binding]; other site
434923001525	metal binding site [ion binding]; metal-binding site
434923001526	Trehalase; Region: Trehalase; cl17346
434923001527	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
434923001528	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
434923001529	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
434923001530	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
434923001531	active site
434923001532	GMP synthase; Reviewed; Region: guaA; PRK00074
434923001533	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
434923001534	AMP/PPi binding site [chemical binding]; other site
434923001535	candidate oxyanion hole; other site
434923001536	catalytic triad [active]
434923001537	potential glutamine specificity residues [chemical binding]; other site
434923001538	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
434923001539	ATP Binding subdomain [chemical binding]; other site
434923001540	Ligand Binding sites [chemical binding]; other site
434923001541	Dimerization subdomain; other site
434923001542	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
434923001543	RNA/DNA hybrid binding site [nucleotide binding]; other site
434923001544	active site
434923001545	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
434923001546	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
434923001547	ATP-grasp domain; Region: ATP-grasp_4; cl17255
434923001548	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
434923001549	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
434923001550	putative active site [active]
434923001551	putative PHP Thumb interface [polypeptide binding]; other site
434923001552	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
434923001553	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
434923001554	generic binding surface II; other site
434923001555	generic binding surface I; other site
434923001556	EamA-like transporter family; Region: EamA; pfam00892
434923001557	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
434923001558	EamA-like transporter family; Region: EamA; pfam00892
434923001559	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
434923001560	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
434923001561	similar to hypothetical protein
434923001562	FOG: CBS domain [General function prediction only]; Region: COG0517
434923001563	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
434923001564	probable polyamine oxidase; Region: PLN02268
434923001565	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
434923001566	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
434923001567	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923001568	FeS/SAM binding site; other site
434923001569	Methyltransferase domain; Region: Methyltransf_31; pfam13847
434923001570	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
434923001571	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
434923001572	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
434923001573	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
434923001574	active site
434923001575	dimer interface [polypeptide binding]; other site
434923001576	motif 1; other site
434923001577	motif 2; other site
434923001578	motif 3; other site
434923001579	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
434923001580	anticodon binding site; other site
434923001581	translation initiation factor IF-3; Region: infC; TIGR00168
434923001582	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
434923001583	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
434923001584	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
434923001585	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923001586	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
434923001587	23S rRNA binding site [nucleotide binding]; other site
434923001588	L21 binding site [polypeptide binding]; other site
434923001589	L13 binding site [polypeptide binding]; other site
434923001590	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
434923001591	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
434923001592	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
434923001593	dimer interface [polypeptide binding]; other site
434923001594	motif 1; other site
434923001595	active site
434923001596	motif 2; other site
434923001597	motif 3; other site
434923001598	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
434923001599	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
434923001600	putative tRNA-binding site [nucleotide binding]; other site
434923001601	B3/4 domain; Region: B3_4; pfam03483
434923001602	tRNA synthetase B5 domain; Region: B5; smart00874
434923001603	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
434923001604	dimer interface [polypeptide binding]; other site
434923001605	motif 1; other site
434923001606	motif 3; other site
434923001607	motif 2; other site
434923001608	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
434923001609	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
434923001610	IHF dimer interface [polypeptide binding]; other site
434923001611	IHF - DNA interface [nucleotide binding]; other site
434923001612	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
434923001613	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
434923001614	DNA binding residues [nucleotide binding]
434923001615	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
434923001616	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
434923001617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923001618	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
434923001619	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
434923001620	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
434923001621	methionine sulfoxide reductase A; Provisional; Region: PRK14054
434923001622	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
434923001623	SmpB-tmRNA interface; other site
434923001624	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
434923001625	putative coenzyme Q binding site [chemical binding]; other site
434923001626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
434923001627	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
434923001628	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
434923001629	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
434923001630	metal binding site 2 [ion binding]; metal-binding site
434923001631	putative DNA binding helix; other site
434923001632	metal binding site 1 [ion binding]; metal-binding site
434923001633	dimer interface [polypeptide binding]; other site
434923001634	structural Zn2+ binding site [ion binding]; other site
434923001635	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
434923001636	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
434923001637	Walker A/P-loop; other site
434923001638	ATP binding site [chemical binding]; other site
434923001639	Q-loop/lid; other site
434923001640	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
434923001641	ABC transporter signature motif; other site
434923001642	Walker B; other site
434923001643	D-loop; other site
434923001644	H-loop/switch region; other site
434923001645	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
434923001646	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
434923001647	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
434923001648	oligomeric interface; other site
434923001649	putative active site [active]
434923001650	homodimer interface [polypeptide binding]; other site
434923001651	GrpE; Region: GrpE; pfam01025
434923001652	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
434923001653	dimer interface [polypeptide binding]; other site
434923001654	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
434923001655	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923001656	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
434923001657	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
434923001658	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
434923001659	carboxyltransferase (CT) interaction site; other site
434923001660	biotinylation site [posttranslational modification]; other site
434923001661	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
434923001662	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
434923001663	nucleotide binding site [chemical binding]; other site
434923001664	chaperone protein DnaJ; Provisional; Region: PRK10767
434923001665	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
434923001666	HSP70 interaction site [polypeptide binding]; other site
434923001667	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
434923001668	Zn binding sites [ion binding]; other site
434923001669	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
434923001670	dimer interface [polypeptide binding]; other site
434923001671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923001672	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923001673	putative substrate translocation pore; other site
434923001674	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923001675	AAA domain; Region: AAA_14; pfam13173
434923001676	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
434923001677	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
434923001678	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
434923001679	catalytic site [active]
434923001680	subunit interface [polypeptide binding]; other site
434923001681	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
434923001682	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
434923001683	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
434923001684	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
434923001685	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
434923001686	ATP-grasp domain; Region: ATP-grasp_4; cl17255
434923001687	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
434923001688	IMP binding site; other site
434923001689	dimer interface [polypeptide binding]; other site
434923001690	interdomain contacts; other site
434923001691	partial ornithine binding site; other site
434923001692	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
434923001693	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
434923001694	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
434923001695	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923001696	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
434923001697	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
434923001698	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
434923001699	putative catalytic residue [active]
434923001700	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
434923001701	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
434923001702	active site
434923001703	intersubunit interface [polypeptide binding]; other site
434923001704	catalytic residue [active]
434923001705	short chain dehydrogenase; Provisional; Region: PRK07890
434923001706	classical (c) SDRs; Region: SDR_c; cd05233
434923001707	NAD(P) binding site [chemical binding]; other site
434923001708	active site
434923001709	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
434923001710	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
434923001711	metal binding site [ion binding]; metal-binding site
434923001712	substrate binding pocket [chemical binding]; other site
434923001713	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
434923001714	6-phosphofructokinase; Provisional; Region: PRK14072
434923001715	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
434923001716	active site
434923001717	ADP/pyrophosphate binding site [chemical binding]; other site
434923001718	dimerization interface [polypeptide binding]; other site
434923001719	allosteric effector site; other site
434923001720	fructose-1,6-bisphosphate binding site; other site
434923001721	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
434923001722	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
434923001723	active site
434923001724	zinc binding site [ion binding]; other site
434923001725	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001726	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001727	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001728	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
434923001729	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
434923001730	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
434923001731	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
434923001732	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
434923001733	active site
434923001734	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
434923001735	LssY C-terminus; Region: LssY_C; pfam14067
434923001736	lipoyl synthase; Provisional; Region: PRK05481
434923001737	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923001738	FeS/SAM binding site; other site
434923001739	lipoate-protein ligase B; Provisional; Region: PRK14342
434923001740	Protein of unknown function (DUF493); Region: DUF493; pfam04359
434923001741	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
434923001742	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
434923001743	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
434923001744	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
434923001745	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
434923001746	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
434923001747	active site
434923001748	multimer interface [polypeptide binding]; other site
434923001749	SnoaL-like domain; Region: SnoaL_2; pfam12680
434923001750	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
434923001751	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
434923001752	substrate binding pocket [chemical binding]; other site
434923001753	chain length determination region; other site
434923001754	substrate-Mg2+ binding site; other site
434923001755	catalytic residues [active]
434923001756	aspartate-rich region 1; other site
434923001757	active site lid residues [active]
434923001758	aspartate-rich region 2; other site
434923001759	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
434923001760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923001761	FeS/SAM binding site; other site
434923001762	Fic family protein [Function unknown]; Region: COG3177
434923001763	Fic/DOC family; Region: Fic; pfam02661
434923001764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923001765	non-specific DNA binding site [nucleotide binding]; other site
434923001766	salt bridge; other site
434923001767	sequence-specific DNA binding site [nucleotide binding]; other site
434923001768	histidyl-tRNA synthetase; Region: hisS; TIGR00442
434923001769	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
434923001770	dimer interface [polypeptide binding]; other site
434923001771	motif 1; other site
434923001772	active site
434923001773	motif 2; other site
434923001774	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
434923001775	anticodon binding site; other site
434923001776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
434923001777	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
434923001778	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
434923001779	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
434923001780	G1 box; other site
434923001781	GTP/Mg2+ binding site [chemical binding]; other site
434923001782	Switch I region; other site
434923001783	G2 box; other site
434923001784	Switch II region; other site
434923001785	G3 box; other site
434923001786	G4 box; other site
434923001787	G5 box; other site
434923001788	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
434923001789	G1 box; other site
434923001790	GTP/Mg2+ binding site [chemical binding]; other site
434923001791	Switch I region; other site
434923001792	G2 box; other site
434923001793	G3 box; other site
434923001794	Switch II region; other site
434923001795	G4 box; other site
434923001796	G5 box; other site
434923001797	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
434923001798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923001799	putative substrate translocation pore; other site
434923001800	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
434923001801	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
434923001802	generic binding surface II; other site
434923001803	generic binding surface I; other site
434923001804	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
434923001805	malate dehydrogenase; Provisional; Region: PRK05442
434923001806	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
434923001807	NAD(P) binding site [chemical binding]; other site
434923001808	dimer interface [polypeptide binding]; other site
434923001809	malate binding site [chemical binding]; other site
434923001810	UGMP family protein; Validated; Region: PRK09604
434923001811	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
434923001812	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
434923001813	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
434923001814	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
434923001815	oligomeric interface; other site
434923001816	homodimer interface [polypeptide binding]; other site
434923001817	putative active site [active]
434923001818	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
434923001819	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
434923001820	catalytic site [active]
434923001821	putative active site [active]
434923001822	putative substrate binding site [chemical binding]; other site
434923001823	dimer interface [polypeptide binding]; other site
434923001824	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923001825	AAA domain; Region: AAA_14; pfam13173
434923001826	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
434923001827	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
434923001828	Part of AAA domain; Region: AAA_19; pfam13245
434923001829	Family description; Region: UvrD_C_2; pfam13538
434923001830	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
434923001831	probable DNA repair protein; Region: TIGR03623
434923001832	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
434923001833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
434923001834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923001835	dimer interface [polypeptide binding]; other site
434923001836	phosphorylation site [posttranslational modification]
434923001837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923001838	ATP binding site [chemical binding]; other site
434923001839	Mg2+ binding site [ion binding]; other site
434923001840	G-X-G motif; other site
434923001841	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
434923001842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923001843	active site
434923001844	phosphorylation site [posttranslational modification]
434923001845	intermolecular recognition site; other site
434923001846	dimerization interface [polypeptide binding]; other site
434923001847	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
434923001848	DNA binding site [nucleotide binding]
434923001849	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
434923001850	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
434923001851	haloalkane dehalogenase; Provisional; Region: PRK03592
434923001852	RmuC family; Region: RmuC; pfam02646
434923001853	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
434923001854	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
434923001855	substrate binding site [chemical binding]; other site
434923001856	ATP binding site [chemical binding]; other site
434923001857	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
434923001858	dihydrodipicolinate synthase; Region: dapA; TIGR00674
434923001859	dimer interface [polypeptide binding]; other site
434923001860	active site
434923001861	catalytic residue [active]
434923001862	Nucleoporin subcomplex protein binding to Pom34; Region: Nup188; pfam10487
434923001863	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
434923001864	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
434923001865	ATP binding site [chemical binding]; other site
434923001866	active site
434923001867	substrate binding site [chemical binding]; other site
434923001868	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001869	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001870	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001871	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923001872	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
434923001873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923001874	putative substrate translocation pore; other site
434923001875	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923001876	Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222
434923001877	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
434923001878	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
434923001879	NAD(P) binding site [chemical binding]; other site
434923001880	catalytic residues [active]
434923001881	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
434923001882	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
434923001883	active site
434923001884	FMN binding site [chemical binding]; other site
434923001885	substrate binding site [chemical binding]; other site
434923001886	3Fe-4S cluster binding site [ion binding]; other site
434923001887	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
434923001888	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
434923001889	isocitrate dehydrogenase; Validated; Region: PRK07362
434923001890	isocitrate dehydrogenase; Reviewed; Region: PRK07006
434923001891	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
434923001892	Clp amino terminal domain; Region: Clp_N; pfam02861
434923001893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923001894	Walker A motif; other site
434923001895	ATP binding site [chemical binding]; other site
434923001896	Walker B motif; other site
434923001897	arginine finger; other site
434923001898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923001899	Walker A motif; other site
434923001900	ATP binding site [chemical binding]; other site
434923001901	Walker B motif; other site
434923001902	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
434923001903	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
434923001904	rRNA binding site [nucleotide binding]; other site
434923001905	predicted 30S ribosome binding site; other site
434923001906	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
434923001907	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
434923001908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
434923001909	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
434923001910	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
434923001911	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
434923001912	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
434923001913	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
434923001914	recombination factor protein RarA; Reviewed; Region: PRK13342
434923001915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923001916	Walker A motif; other site
434923001917	ATP binding site [chemical binding]; other site
434923001918	Walker B motif; other site
434923001919	arginine finger; other site
434923001920	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
434923001921	seryl-tRNA synthetase; Provisional; Region: PRK05431
434923001922	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
434923001923	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
434923001924	dimer interface [polypeptide binding]; other site
434923001925	active site
434923001926	motif 1; other site
434923001927	motif 2; other site
434923001928	motif 3; other site
434923001929	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
434923001930	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923001931	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923001932	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923001933	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
434923001934	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
434923001935	GIY-YIG motif/motif A; other site
434923001936	active site
434923001937	catalytic site [active]
434923001938	putative DNA binding site [nucleotide binding]; other site
434923001939	metal binding site [ion binding]; metal-binding site
434923001940	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
434923001941	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
434923001942	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
434923001943	putative acyl-acceptor binding pocket; other site
434923001944	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
434923001945	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
434923001946	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
434923001947	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
434923001948	catalytic residue [active]
434923001949	Thiamine biosynthesis ATP pyrophosphatase [Coenzyme metabolism]; Region: ThiI; COG0301
434923001950	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
434923001951	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
434923001952	Ligand Binding Site [chemical binding]; other site
434923001953	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
434923001954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923001955	putative substrate translocation pore; other site
434923001956	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923001957	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
434923001958	DNA photolyase; Region: DNA_photolyase; pfam00875
434923001959	hypothetical protein; Reviewed; Region: PRK09588
434923001960	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
434923001961	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
434923001962	Domain of unknown function (DUF378); Region: DUF378; pfam04070
434923001963	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
434923001964	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
434923001965	putative dimer interface [polypeptide binding]; other site
434923001966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923001967	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923001968	putative substrate translocation pore; other site
434923001969	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923001970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923001971	TPR repeat; Region: TPR_11; pfam13414
434923001972	binding surface
434923001973	TPR motif; other site
434923001974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
434923001975	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
434923001976	active site
434923001977	ribulose/triose binding site [chemical binding]; other site
434923001978	phosphate binding site [ion binding]; other site
434923001979	substrate (anthranilate) binding pocket [chemical binding]; other site
434923001980	product (indole) binding pocket [chemical binding]; other site
434923001981	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
434923001982	Eukaryotic phosphomannomutase; Region: PMM; cl17107
434923001983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923001984	motif II; other site
434923001985	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
434923001986	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
434923001987	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
434923001988	ATP binding site [chemical binding]; other site
434923001989	putative Mg++ binding site [ion binding]; other site
434923001990	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
434923001991	nucleotide binding region [chemical binding]; other site
434923001992	ATP-binding site [chemical binding]; other site
434923001993	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
434923001994	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
434923001995	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
434923001996	Ligand Binding Site [chemical binding]; other site
434923001997	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
434923001998	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
434923001999	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
434923002000	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
434923002001	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
434923002002	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
434923002003	Protein export membrane protein; Region: SecD_SecF; pfam02355
434923002004	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923002005	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
434923002006	Sel1-like repeats; Region: SEL1; smart00671
434923002007	Sel1-like repeats; Region: SEL1; smart00671
434923002008	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
434923002009	Sel1-like repeats; Region: SEL1; smart00671
434923002010	Sel1-like repeats; Region: SEL1; smart00671
434923002011	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
434923002012	Sel1-like repeats; Region: SEL1; smart00671
434923002013	Sel1-like repeats; Region: SEL1; smart00671
434923002014	Sel1-like repeats; Region: SEL1; smart00671
434923002015	Sel1-like repeats; Region: SEL1; smart00671
434923002016	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
434923002017	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
434923002018	active site
434923002019	dimerization interface [polypeptide binding]; other site
434923002020	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
434923002021	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
434923002022	OPT oligopeptide transporter protein; Region: OPT; cl14607
434923002023	putative oligopeptide transporter, OPT family; Region: TIGR00733
434923002024	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
434923002025	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
434923002026	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
434923002027	catalytic residue [active]
434923002028	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
434923002029	trimerization site [polypeptide binding]; other site
434923002030	active site
434923002031	HPP family; Region: HPP; pfam04982
434923002032	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
434923002033	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
434923002034	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
434923002035	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
434923002036	HSP70 interaction site [polypeptide binding]; other site
434923002037	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
434923002038	substrate binding site [polypeptide binding]; other site
434923002039	dimer interface [polypeptide binding]; other site
434923002040	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923002041	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
434923002042	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
434923002043	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
434923002044	Dienelactone hydrolase family; Region: DLH; pfam01738
434923002045	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
434923002046	Electron transfer flavoprotein domain; Region: ETF; pfam01012
434923002047	Ligand binding site [chemical binding]; other site
434923002048	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
434923002049	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
434923002050	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
434923002051	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
434923002052	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
434923002053	hexamer interface [polypeptide binding]; other site
434923002054	ligand binding site [chemical binding]; other site
434923002055	putative active site [active]
434923002056	NAD(P) binding site [chemical binding]; other site
434923002057	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
434923002058	GIY-YIG motif/motif A; other site
434923002059	putative active site [active]
434923002060	putative metal binding site [ion binding]; other site
434923002061	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
434923002062	MltA specific insert domain; Region: MltA; smart00925
434923002063	3D domain; Region: 3D; pfam06725
434923002064	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
434923002065	N-acetyl-D-glucosamine binding site [chemical binding]; other site
434923002066	catalytic residue [active]
434923002067	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
434923002068	signal peptidase I; Provisional; Region: PRK10861
434923002069	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
434923002070	Catalytic site [active]
434923002071	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
434923002072	fumarate hydratase; Reviewed; Region: fumC; PRK00485
434923002073	Class II fumarases; Region: Fumarase_classII; cd01362
434923002074	active site
434923002075	tetramer interface [polypeptide binding]; other site
434923002076	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
434923002077	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
434923002078	HlyD family secretion protein; Region: HlyD_3; pfam13437
434923002079	multidrug efflux protein; Reviewed; Region: PRK09579
434923002080	ribonuclease R; Region: RNase_R; TIGR02063
434923002081	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
434923002082	RNB domain; Region: RNB; pfam00773
434923002083	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
434923002084	RNA binding site [nucleotide binding]; other site
434923002085	Uncharacterized conserved protein [Function unknown]; Region: COG0062
434923002086	putative carbohydrate kinase; Provisional; Region: PRK10565
434923002087	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
434923002088	putative substrate binding site [chemical binding]; other site
434923002089	putative ATP binding site [chemical binding]; other site
434923002090	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
434923002091	AMIN domain; Region: AMIN; pfam11741
434923002092	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
434923002093	active site
434923002094	metal binding site [ion binding]; metal-binding site
434923002095	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
434923002096	PAS fold; Region: PAS_3; pfam08447
434923002097	putative active site [active]
434923002098	heme pocket [chemical binding]; other site
434923002099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
434923002100	PAS fold; Region: PAS_3; pfam08447
434923002101	putative active site [active]
434923002102	heme pocket [chemical binding]; other site
434923002103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923002104	dimer interface [polypeptide binding]; other site
434923002105	phosphorylation site [posttranslational modification]
434923002106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923002107	ATP binding site [chemical binding]; other site
434923002108	Mg2+ binding site [ion binding]; other site
434923002109	G-X-G motif; other site
434923002110	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
434923002111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923002112	active site
434923002113	phosphorylation site [posttranslational modification]
434923002114	intermolecular recognition site; other site
434923002115	dimerization interface [polypeptide binding]; other site
434923002116	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
434923002117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923002118	ATP binding site [chemical binding]; other site
434923002119	Mg2+ binding site [ion binding]; other site
434923002120	G-X-G motif; other site
434923002121	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
434923002122	ATP binding site [chemical binding]; other site
434923002123	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
434923002124	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
434923002125	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
434923002126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
434923002127	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923002128	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
434923002129	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
434923002130	beta-hexosaminidase; Provisional; Region: PRK05337
434923002131	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
434923002132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923002133	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923002134	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923002135	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
434923002136	Mechanosensitive ion channel; Region: MS_channel; pfam00924
434923002137	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
434923002138	active site
434923002139	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
434923002140	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
434923002141	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
434923002142	Predicted membrane protein [Function unknown]; Region: COG2259
434923002143	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
434923002144	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
434923002145	Ligand Binding Site [chemical binding]; other site
434923002146	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
434923002147	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
434923002148	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923002149	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
434923002150	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
434923002151	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
434923002152	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
434923002153	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
434923002154	RNA binding surface [nucleotide binding]; other site
434923002155	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
434923002156	probable active site [active]
434923002157	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
434923002158	Ligand binding site; other site
434923002159	Putative Catalytic site; other site
434923002160	DXD motif; other site
434923002161	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
434923002162	MutS domain I; Region: MutS_I; pfam01624
434923002163	MutS domain II; Region: MutS_II; pfam05188
434923002164	MutS domain III; Region: MutS_III; pfam05192
434923002165	MutS domain V; Region: MutS_V; pfam00488
434923002166	Walker A/P-loop; other site
434923002167	ATP binding site [chemical binding]; other site
434923002168	Q-loop/lid; other site
434923002169	ABC transporter signature motif; other site
434923002170	Walker B; other site
434923002171	D-loop; other site
434923002172	H-loop/switch region; other site
434923002173	Competence-damaged protein; Region: CinA; pfam02464
434923002174	recombinase A; Provisional; Region: recA; PRK09354
434923002175	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
434923002176	hexamer interface [polypeptide binding]; other site
434923002177	Walker A motif; other site
434923002178	ATP binding site [chemical binding]; other site
434923002179	Walker B motif; other site
434923002180	recombination regulator RecX; Reviewed; Region: recX; PRK00117
434923002181	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
434923002182	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
434923002183	motif 1; other site
434923002184	active site
434923002185	motif 2; other site
434923002186	motif 3; other site
434923002187	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
434923002188	DHHA1 domain; Region: DHHA1; pfam02272
434923002189	aspartate kinase; Reviewed; Region: PRK06635
434923002190	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
434923002191	putative nucleotide binding site [chemical binding]; other site
434923002192	putative catalytic residues [active]
434923002193	putative Mg ion binding site [ion binding]; other site
434923002194	putative aspartate binding site [chemical binding]; other site
434923002195	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
434923002196	putative allosteric regulatory site; other site
434923002197	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
434923002198	putative allosteric regulatory residue; other site
434923002199	carbon storage regulator; Provisional; Region: PRK01712
434923002200	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
434923002201	Transposase [DNA replication, recombination, and repair]; Region: COG5433
434923002202	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
434923002203	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
434923002204	response regulator; Provisional; Region: PRK09483
434923002205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923002206	active site
434923002207	phosphorylation site [posttranslational modification]
434923002208	intermolecular recognition site; other site
434923002209	dimerization interface [polypeptide binding]; other site
434923002210	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
434923002211	DNA binding residues [nucleotide binding]
434923002212	dimerization interface [polypeptide binding]; other site
434923002213	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
434923002214	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
434923002215	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
434923002216	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
434923002217	D-pathway; other site
434923002218	Putative ubiquinol binding site [chemical binding]; other site
434923002219	Low-spin heme (heme b) binding site [chemical binding]; other site
434923002220	Putative water exit pathway; other site
434923002221	Binuclear center (heme o3/CuB) [ion binding]; other site
434923002222	K-pathway; other site
434923002223	Putative proton exit pathway; other site
434923002224	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
434923002225	Subunit I/III interface [polypeptide binding]; other site
434923002226	Subunit III/IV interface [polypeptide binding]; other site
434923002227	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
434923002228	MarR family; Region: MarR_2; pfam12802
434923002229	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
434923002230	catalytic triad [active]
434923002231	metal binding site [ion binding]; metal-binding site
434923002232	conserved cis-peptide bond; other site
434923002233	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
434923002234	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
434923002235	active site
434923002236	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
434923002237	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
434923002238	catalytic residue [active]
434923002239	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
434923002240	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923002241	Walker A motif; other site
434923002242	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
434923002243	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
434923002244	putative NAD(P) binding site [chemical binding]; other site
434923002245	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
434923002246	active site
434923002247	NTP binding site [chemical binding]; other site
434923002248	metal binding triad [ion binding]; metal-binding site
434923002249	antibiotic binding site [chemical binding]; other site
434923002250	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
434923002251	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
434923002252	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
434923002253	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
434923002254	inhibitor-cofactor binding pocket; inhibition site
434923002255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923002256	catalytic residue [active]
434923002257	biotin synthase; Region: bioB; TIGR00433
434923002258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923002259	FeS/SAM binding site; other site
434923002260	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
434923002261	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
434923002262	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
434923002263	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
434923002264	catalytic residue [active]
434923002265	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
434923002266	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
434923002267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923002268	S-adenosylmethionine binding site [chemical binding]; other site
434923002269	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
434923002270	AAA domain; Region: AAA_26; pfam13500
434923002271	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
434923002272	Biotin operon repressor [Transcription]; Region: BirA; COG1654
434923002273	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
434923002274	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
434923002275	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
434923002276	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
434923002277	FtsX-like permease family; Region: FtsX; pfam02687
434923002278	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
434923002279	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
434923002280	Walker A/P-loop; other site
434923002281	ATP binding site [chemical binding]; other site
434923002282	Q-loop/lid; other site
434923002283	ABC transporter signature motif; other site
434923002284	Walker B; other site
434923002285	D-loop; other site
434923002286	H-loop/switch region; other site
434923002287	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
434923002288	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
434923002289	HflX GTPase family; Region: HflX; cd01878
434923002290	G1 box; other site
434923002291	GTP/Mg2+ binding site [chemical binding]; other site
434923002292	Switch I region; other site
434923002293	G2 box; other site
434923002294	G3 box; other site
434923002295	Switch II region; other site
434923002296	G4 box; other site
434923002297	G5 box; other site
434923002298	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
434923002299	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
434923002300	GDP-binding site [chemical binding]; other site
434923002301	ACT binding site; other site
434923002302	IMP binding site; other site
434923002303	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
434923002304	UbiA prenyltransferase family; Region: UbiA; pfam01040
434923002305	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
434923002306	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
434923002307	active site
434923002308	catalytic residues [active]
434923002309	metal binding site [ion binding]; metal-binding site
434923002310	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
434923002311	ligand binding site [chemical binding]; other site
434923002312	active site
434923002313	UGI interface [polypeptide binding]; other site
434923002314	catalytic site [active]
434923002315	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
434923002316	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
434923002317	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
434923002318	Sporulation related domain; Region: SPOR; pfam05036
434923002319	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
434923002320	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
434923002321	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
434923002322	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
434923002323	arogenate dehydrogenase; Region: PLN02256
434923002324	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
434923002325	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
434923002326	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
434923002327	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
434923002328	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
434923002329	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
434923002330	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
434923002331	carboxyltransferase (CT) interaction site; other site
434923002332	biotinylation site [posttranslational modification]; other site
434923002333	enoyl-CoA hydratase; Provisional; Region: PRK05995
434923002334	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
434923002335	substrate binding site [chemical binding]; other site
434923002336	oxyanion hole (OAH) forming residues; other site
434923002337	trimer interface [polypeptide binding]; other site
434923002338	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
434923002339	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
434923002340	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
434923002341	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
434923002342	dimer interface [polypeptide binding]; other site
434923002343	active site
434923002344	isovaleryl-CoA dehydrogenase; Region: PLN02519
434923002345	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
434923002346	substrate binding site [chemical binding]; other site
434923002347	FAD binding site [chemical binding]; other site
434923002348	catalytic base [active]
434923002349	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
434923002350	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
434923002351	quinone interaction residues [chemical binding]; other site
434923002352	active site
434923002353	catalytic residues [active]
434923002354	FMN binding site [chemical binding]; other site
434923002355	substrate binding site [chemical binding]; other site
434923002356	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
434923002357	PLD-like domain; Region: PLDc_2; pfam13091
434923002358	putative active site [active]
434923002359	catalytic site [active]
434923002360	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
434923002361	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
434923002362	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
434923002363	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
434923002364	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
434923002365	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
434923002366	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
434923002367	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
434923002368	catalytic triad [active]
434923002369	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
434923002370	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
434923002371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923002372	non-specific DNA binding site [nucleotide binding]; other site
434923002373	salt bridge; other site
434923002374	sequence-specific DNA binding site [nucleotide binding]; other site
434923002375	Cupin domain; Region: Cupin_2; pfam07883
434923002376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923002377	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
434923002378	putative substrate translocation pore; other site
434923002379	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
434923002380	response regulator; Provisional; Region: PRK09483
434923002381	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923002382	active site
434923002383	phosphorylation site [posttranslational modification]
434923002384	intermolecular recognition site; other site
434923002385	dimerization interface [polypeptide binding]; other site
434923002386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
434923002387	DNA binding residues [nucleotide binding]
434923002388	dimerization interface [polypeptide binding]; other site
434923002389	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
434923002390	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
434923002391	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
434923002392	Fic/DOC family; Region: Fic; pfam02661
434923002393	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
434923002394	active site residue [active]
434923002395	oxidative damage protection protein; Provisional; Region: PRK05408
434923002396	adenine DNA glycosylase; Provisional; Region: PRK10880
434923002397	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
434923002398	minor groove reading motif; other site
434923002399	helix-hairpin-helix signature motif; other site
434923002400	substrate binding pocket [chemical binding]; other site
434923002401	active site
434923002402	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
434923002403	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
434923002404	DNA binding and oxoG recognition site [nucleotide binding]
434923002405	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
434923002406	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
434923002407	Putative methyltransferase; Region: Methyltransf_4; cl17290
434923002408	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
434923002409	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
434923002410	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
434923002411	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
434923002412	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
434923002413	Walker A/P-loop; other site
434923002414	ATP binding site [chemical binding]; other site
434923002415	Q-loop/lid; other site
434923002416	ABC transporter signature motif; other site
434923002417	Walker B; other site
434923002418	D-loop; other site
434923002419	H-loop/switch region; other site
434923002420	inner membrane transport permease; Provisional; Region: PRK15066
434923002421	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
434923002422	glycerol kinase; Provisional; Region: glpK; PRK00047
434923002423	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
434923002424	N- and C-terminal domain interface [polypeptide binding]; other site
434923002425	active site
434923002426	MgATP binding site [chemical binding]; other site
434923002427	catalytic site [active]
434923002428	metal binding site [ion binding]; metal-binding site
434923002429	glycerol binding site [chemical binding]; other site
434923002430	homotetramer interface [polypeptide binding]; other site
434923002431	homodimer interface [polypeptide binding]; other site
434923002432	FBP binding site [chemical binding]; other site
434923002433	protein IIAGlc interface [polypeptide binding]; other site
434923002434	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
434923002435	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
434923002436	active site
434923002437	DNA binding site [nucleotide binding]
434923002438	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
434923002439	classical (c) SDRs; Region: SDR_c; cd05233
434923002440	NAD(P) binding site [chemical binding]; other site
434923002441	active site
434923002442	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
434923002443	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
434923002444	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
434923002445	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
434923002446	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
434923002447	lytic murein transglycosylase; Region: MltB_2; TIGR02283
434923002448	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
434923002449	N-acetyl-D-glucosamine binding site [chemical binding]; other site
434923002450	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
434923002451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923002452	S-adenosylmethionine binding site [chemical binding]; other site
434923002453	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
434923002454	Domain of unknown function DUF20; Region: UPF0118; pfam01594
434923002455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923002456	putative substrate translocation pore; other site
434923002457	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923002458	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
434923002459	Fatty acid desaturase; Region: FA_desaturase; pfam00487
434923002460	Di-iron ligands [ion binding]; other site
434923002461	K+ potassium transporter; Region: K_trans; cl15781
434923002462	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
434923002463	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
434923002464	ligand binding site [chemical binding]; other site
434923002465	flexible hinge region; other site
434923002466	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
434923002467	putative catalytic site [active]
434923002468	putative metal binding site [ion binding]; other site
434923002469	putative phosphate binding site [ion binding]; other site
434923002470	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
434923002471	CoenzymeA binding site [chemical binding]; other site
434923002472	subunit interaction site [polypeptide binding]; other site
434923002473	PHB binding site; other site
434923002474	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
434923002475	2-methylcitrate dehydratase; Region: prpD; TIGR02330
434923002476	Phosphotransferase enzyme family; Region: APH; pfam01636
434923002477	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
434923002478	active site
434923002479	ATP binding site [chemical binding]; other site
434923002480	substrate binding site [chemical binding]; other site
434923002481	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
434923002482	intracellular septation protein A; Reviewed; Region: PRK00259
434923002483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923002484	putative substrate translocation pore; other site
434923002485	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923002486	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
434923002487	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
434923002488	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
434923002489	FMN binding site [chemical binding]; other site
434923002490	active site
434923002491	catalytic residues [active]
434923002492	substrate binding site [chemical binding]; other site
434923002493	Protein required for attachment to host cells; Region: Host_attach; pfam10116
434923002494	Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; Region: TY; cd00191
434923002495	protease interaction site; other site
434923002496	amidophosphoribosyltransferase; Provisional; Region: PRK09246
434923002497	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
434923002498	tetramer interface [polypeptide binding]; other site
434923002499	active site
434923002500	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
434923002501	active site
434923002502	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
434923002503	Colicin V production protein; Region: Colicin_V; cl00567
434923002504	Sporulation related domain; Region: SPOR; pfam05036
434923002505	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
434923002506	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
434923002507	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
434923002508	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
434923002509	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
434923002510	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
434923002511	dimerization interface 3.5A [polypeptide binding]; other site
434923002512	active site
434923002513	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
434923002514	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
434923002515	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
434923002516	Thioredoxin; Region: Thioredoxin_4; pfam13462
434923002517	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
434923002518	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
434923002519	Flavoprotein; Region: Flavoprotein; pfam02441
434923002520	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
434923002521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923002522	active site
434923002523	motif I; other site
434923002524	motif II; other site
434923002525	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
434923002526	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
434923002527	G1 box; other site
434923002528	putative GEF interaction site [polypeptide binding]; other site
434923002529	GTP/Mg2+ binding site [chemical binding]; other site
434923002530	Switch I region; other site
434923002531	G2 box; other site
434923002532	G3 box; other site
434923002533	Switch II region; other site
434923002534	G4 box; other site
434923002535	G5 box; other site
434923002536	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
434923002537	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
434923002538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
434923002539	Integrase core domain; Region: rve; pfam00665
434923002540	Integrase core domain; Region: rve_3; pfam13683
434923002541	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
434923002542	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
434923002543	ATP binding site [chemical binding]; other site
434923002544	substrate interface [chemical binding]; other site
434923002545	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
434923002546	active site residue [active]
434923002547	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
434923002548	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
434923002549	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
434923002550	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
434923002551	Tetramer interface [polypeptide binding]; other site
434923002552	active site
434923002553	FMN-binding site [chemical binding]; other site
434923002554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
434923002555	Smr domain; Region: Smr; pfam01713
434923002556	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
434923002557	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
434923002558	Sugar specificity; other site
434923002559	Pyrimidine base specificity; other site
434923002560	ATP-binding site [chemical binding]; other site
434923002561	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
434923002562	alanine racemase; Reviewed; Region: alr; PRK00053
434923002563	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
434923002564	active site
434923002565	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
434923002566	substrate binding site [chemical binding]; other site
434923002567	catalytic residues [active]
434923002568	dimer interface [polypeptide binding]; other site
434923002569	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
434923002570	AAA domain; Region: AAA_25; pfam13481
434923002571	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
434923002572	Walker A motif; other site
434923002573	ATP binding site [chemical binding]; other site
434923002574	Walker B motif; other site
434923002575	DNA binding loops [nucleotide binding]
434923002576	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
434923002577	protein-splicing catalytic site; other site
434923002578	thioester formation/cholesterol transfer; other site
434923002579	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923002580	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
434923002581	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
434923002582	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
434923002583	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
434923002584	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
434923002585	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
434923002586	NAD synthetase; Provisional; Region: PRK13981
434923002587	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
434923002588	multimer interface [polypeptide binding]; other site
434923002589	active site
434923002590	catalytic triad [active]
434923002591	protein interface 1 [polypeptide binding]; other site
434923002592	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
434923002593	homodimer interface [polypeptide binding]; other site
434923002594	NAD binding pocket [chemical binding]; other site
434923002595	ATP binding pocket [chemical binding]; other site
434923002596	Mg binding site [ion binding]; other site
434923002597	active-site loop [active]
434923002598	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
434923002599	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
434923002600	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
434923002601	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
434923002602	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
434923002603	Walker A/P-loop; other site
434923002604	ATP binding site [chemical binding]; other site
434923002605	Q-loop/lid; other site
434923002606	ABC transporter signature motif; other site
434923002607	Walker B; other site
434923002608	D-loop; other site
434923002609	H-loop/switch region; other site
434923002610	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
434923002611	active site
434923002612	dimer interfaces [polypeptide binding]; other site
434923002613	catalytic residues [active]
434923002614	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
434923002615	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
434923002616	RNase E interface [polypeptide binding]; other site
434923002617	trimer interface [polypeptide binding]; other site
434923002618	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
434923002619	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
434923002620	RNase E interface [polypeptide binding]; other site
434923002621	trimer interface [polypeptide binding]; other site
434923002622	active site
434923002623	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
434923002624	putative nucleic acid binding region [nucleotide binding]; other site
434923002625	G-X-X-G motif; other site
434923002626	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
434923002627	RNA binding site [nucleotide binding]; other site
434923002628	domain interface; other site
434923002629	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
434923002630	16S/18S rRNA binding site [nucleotide binding]; other site
434923002631	S13e-L30e interaction site [polypeptide binding]; other site
434923002632	25S rRNA binding site [nucleotide binding]; other site
434923002633	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
434923002634	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
434923002635	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
434923002636	active site
434923002637	tetramer interface; other site
434923002638	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
434923002639	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
434923002640	active site
434923002641	dimer interface [polypeptide binding]; other site
434923002642	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
434923002643	dimer interface [polypeptide binding]; other site
434923002644	active site
434923002645	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
434923002646	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
434923002647	NAD binding site [chemical binding]; other site
434923002648	homodimer interface [polypeptide binding]; other site
434923002649	homotetramer interface [polypeptide binding]; other site
434923002650	active site
434923002651	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
434923002652	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
434923002653	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
434923002654	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
434923002655	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
434923002656	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
434923002657	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
434923002658	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
434923002659	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
434923002660	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
434923002661	putative NAD(P) binding site [chemical binding]; other site
434923002662	active site
434923002663	putative substrate binding site [chemical binding]; other site
434923002664	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
434923002665	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
434923002666	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
434923002667	active site
434923002668	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
434923002669	homodimer interface [polypeptide binding]; other site
434923002670	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
434923002671	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
434923002672	putative ADP-binding pocket [chemical binding]; other site
434923002673	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
434923002674	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
434923002675	active site
434923002676	dimer interface [polypeptide binding]; other site
434923002677	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
434923002678	Ligand Binding Site [chemical binding]; other site
434923002679	Molecular Tunnel; other site
434923002680	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
434923002681	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
434923002682	putative ADP-binding pocket [chemical binding]; other site
434923002683	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
434923002684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
434923002685	putative ADP-binding pocket [chemical binding]; other site
434923002686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923002687	Radical SAM superfamily; Region: Radical_SAM; pfam04055
434923002688	FeS/SAM binding site; other site
434923002689	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
434923002690	Methyltransferase domain; Region: Methyltransf_31; pfam13847
434923002691	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923002692	S-adenosylmethionine binding site [chemical binding]; other site
434923002693	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
434923002694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
434923002695	Walker A/P-loop; other site
434923002696	ATP binding site [chemical binding]; other site
434923002697	Q-loop/lid; other site
434923002698	ABC transporter signature motif; other site
434923002699	Walker B; other site
434923002700	D-loop; other site
434923002701	H-loop/switch region; other site
434923002702	maltose O-acetyltransferase; Provisional; Region: PRK10092
434923002703	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
434923002704	trimer interface [polypeptide binding]; other site
434923002705	active site
434923002706	substrate binding site [chemical binding]; other site
434923002707	CoA binding site [chemical binding]; other site
434923002708	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
434923002709	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
434923002710	active site
434923002711	dimer interface [polypeptide binding]; other site
434923002712	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
434923002713	Ligand Binding Site [chemical binding]; other site
434923002714	Molecular Tunnel; other site
434923002715	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
434923002716	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
434923002717	inhibitor-cofactor binding pocket; inhibition site
434923002718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923002719	catalytic residue [active]
434923002720	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
434923002721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923002722	NAD(P) binding site [chemical binding]; other site
434923002723	active site
434923002724	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
434923002725	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
434923002726	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
434923002727	putative trimer interface [polypeptide binding]; other site
434923002728	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
434923002729	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
434923002730	putative CoA binding site [chemical binding]; other site
434923002731	putative trimer interface [polypeptide binding]; other site
434923002732	putative active site [active]
434923002733	putative substrate binding site [chemical binding]; other site
434923002734	putative CoA binding site [chemical binding]; other site
434923002735	Transcriptional regulators [Transcription]; Region: MarR; COG1846
434923002736	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
434923002737	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
434923002738	transcriptional activator RfaH; Region: RfaH; TIGR01955
434923002739	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
434923002740	heterodimer interface [polypeptide binding]; other site
434923002741	homodimer interface [polypeptide binding]; other site
434923002742	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
434923002743	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
434923002744	inhibitor-cofactor binding pocket; inhibition site
434923002745	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923002746	catalytic residue [active]
434923002747	adenylosuccinate lyase; Provisional; Region: PRK09285
434923002748	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
434923002749	tetramer interface [polypeptide binding]; other site
434923002750	active site
434923002751	malate dehydrogenase; Provisional; Region: PRK13529
434923002752	Malic enzyme, N-terminal domain; Region: malic; pfam00390
434923002753	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
434923002754	NAD(P) binding site [chemical binding]; other site
434923002755	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
434923002756	Fic family protein [Function unknown]; Region: COG3177
434923002757	Fic/DOC family; Region: Fic; pfam02661
434923002758	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
434923002759	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
434923002760	C-terminal domain interface [polypeptide binding]; other site
434923002761	GSH binding site (G-site) [chemical binding]; other site
434923002762	dimer interface [polypeptide binding]; other site
434923002763	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
434923002764	N-terminal domain interface [polypeptide binding]; other site
434923002765	dimer interface [polypeptide binding]; other site
434923002766	substrate binding pocket (H-site) [chemical binding]; other site
434923002767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
434923002768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
434923002769	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
434923002770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
434923002771	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
434923002772	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
434923002773	cation binding site [ion binding]; other site
434923002774	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
434923002775	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
434923002776	G1 box; other site
434923002777	putative GEF interaction site [polypeptide binding]; other site
434923002778	GTP/Mg2+ binding site [chemical binding]; other site
434923002779	Switch I region; other site
434923002780	G2 box; other site
434923002781	G3 box; other site
434923002782	Switch II region; other site
434923002783	G4 box; other site
434923002784	G5 box; other site
434923002785	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
434923002786	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
434923002787	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
434923002788	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
434923002789	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
434923002790	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
434923002791	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
434923002792	HIGH motif; other site
434923002793	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
434923002794	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
434923002795	active site
434923002796	KMSKS motif; other site
434923002797	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
434923002798	tRNA binding surface [nucleotide binding]; other site
434923002799	anticodon binding site; other site
434923002800	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
434923002801	Beta-lactamase; Region: Beta-lactamase; pfam00144
434923002802	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
434923002803	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
434923002804	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
434923002805	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
434923002806	HlyD family secretion protein; Region: HlyD_3; pfam13437
434923002807	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
434923002808	Coenzyme A binding pocket [chemical binding]; other site
434923002809	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
434923002810	active site
434923002811	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
434923002812	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
434923002813	HlyD family secretion protein; Region: HlyD_3; pfam13437
434923002814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923002815	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923002816	putative substrate translocation pore; other site
434923002817	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
434923002818	nucleotide binding site/active site [active]
434923002819	HIT family signature motif; other site
434923002820	catalytic residue [active]
434923002821	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
434923002822	homodecamer interface [polypeptide binding]; other site
434923002823	GTP cyclohydrolase I; Provisional; Region: PLN03044
434923002824	active site
434923002825	putative catalytic site residues [active]
434923002826	zinc binding site [ion binding]; other site
434923002827	GTP-CH-I/GFRP interaction surface; other site
434923002828	YcaO-like family; Region: YcaO; pfam02624
434923002829	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
434923002830	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
434923002831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923002832	PAS fold; Region: PAS_4; pfam08448
434923002833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
434923002834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923002835	dimer interface [polypeptide binding]; other site
434923002836	phosphorylation site [posttranslational modification]
434923002837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923002838	ATP binding site [chemical binding]; other site
434923002839	Mg2+ binding site [ion binding]; other site
434923002840	G-X-G motif; other site
434923002841	Response regulator receiver domain; Region: Response_reg; pfam00072
434923002842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923002843	active site
434923002844	phosphorylation site [posttranslational modification]
434923002845	intermolecular recognition site; other site
434923002846	dimerization interface [polypeptide binding]; other site
434923002847	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
434923002848	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
434923002849	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
434923002850	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
434923002851	active site
434923002852	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
434923002853	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
434923002854	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
434923002855	KR domain; Region: KR; pfam08659
434923002856	putative NADP binding site [chemical binding]; other site
434923002857	active site
434923002858	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
434923002859	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
434923002860	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
434923002861	acyl-activating enzyme (AAE) consensus motif; other site
434923002862	AMP binding site [chemical binding]; other site
434923002863	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
434923002864	CoA-transferase family III; Region: CoA_transf_3; pfam02515
434923002865	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923002866	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923002867	response regulator; Provisional; Region: PRK09483
434923002868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923002869	active site
434923002870	phosphorylation site [posttranslational modification]
434923002871	intermolecular recognition site; other site
434923002872	dimerization interface [polypeptide binding]; other site
434923002873	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
434923002874	DNA binding residues [nucleotide binding]
434923002875	dimerization interface [polypeptide binding]; other site
434923002876	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
434923002877	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
434923002878	Walker A/P-loop; other site
434923002879	ATP binding site [chemical binding]; other site
434923002880	Q-loop/lid; other site
434923002881	ABC transporter signature motif; other site
434923002882	Walker B; other site
434923002883	D-loop; other site
434923002884	H-loop/switch region; other site
434923002885	Predicted transcriptional regulators [Transcription]; Region: COG1725
434923002886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
434923002887	DNA-binding site [nucleotide binding]; DNA binding site
434923002888	PspC domain; Region: PspC; pfam04024
434923002889	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
434923002890	putative dimer interface [polypeptide binding]; other site
434923002891	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
434923002892	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
434923002893	dimer interface [polypeptide binding]; other site
434923002894	Citrate synthase; Region: Citrate_synt; pfam00285
434923002895	active site
434923002896	citrylCoA binding site [chemical binding]; other site
434923002897	oxalacetate/citrate binding site [chemical binding]; other site
434923002898	coenzyme A binding site [chemical binding]; other site
434923002899	catalytic triad [active]
434923002900	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
434923002901	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
434923002902	tetramer interface [polypeptide binding]; other site
434923002903	active site
434923002904	Mg2+/Mn2+ binding site [ion binding]; other site
434923002905	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
434923002906	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
434923002907	catalytic triad [active]
434923002908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923002909	putative substrate translocation pore; other site
434923002910	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
434923002911	active site
434923002912	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
434923002913	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
434923002914	acyl-activating enzyme (AAE) consensus motif; other site
434923002915	putative AMP binding site [chemical binding]; other site
434923002916	putative active site [active]
434923002917	putative CoA binding site [chemical binding]; other site
434923002918	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
434923002919	active site
434923002920	CoA binding site [chemical binding]; other site
434923002921	AMP binding site [chemical binding]; other site
434923002922	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
434923002923	sequence-specific DNA binding site [nucleotide binding]; other site
434923002924	salt bridge; other site
434923002925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923002926	Response regulator receiver domain; Region: Response_reg; pfam00072
434923002927	active site
434923002928	phosphorylation site [posttranslational modification]
434923002929	intermolecular recognition site; other site
434923002930	dimerization interface [polypeptide binding]; other site
434923002931	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
434923002932	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
434923002933	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
434923002934	RNA binding surface [nucleotide binding]; other site
434923002935	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
434923002936	active site
434923002937	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
434923002938	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
434923002939	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
434923002940	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
434923002941	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
434923002942	protein binding site [polypeptide binding]; other site
434923002943	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
434923002944	protein binding site [polypeptide binding]; other site
434923002945	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
434923002946	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
434923002947	HlyD family secretion protein; Region: HlyD_3; pfam13437
434923002948	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
434923002949	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
434923002950	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
434923002951	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
434923002952	hinge; other site
434923002953	active site
434923002954	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
434923002955	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
434923002956	putative active site [active]
434923002957	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
434923002958	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
434923002959	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
434923002960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
434923002961	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
434923002962	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
434923002963	OstA-like protein; Region: OstA; pfam03968
434923002964	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
434923002965	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
434923002966	Walker A/P-loop; other site
434923002967	ATP binding site [chemical binding]; other site
434923002968	Q-loop/lid; other site
434923002969	ABC transporter signature motif; other site
434923002970	Walker B; other site
434923002971	D-loop; other site
434923002972	H-loop/switch region; other site
434923002973	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
434923002974	30S subunit binding site; other site
434923002975	HPr kinase/phosphorylase; Provisional; Region: PRK05428
434923002976	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
434923002977	Hpr binding site; other site
434923002978	active site
434923002979	homohexamer subunit interaction site [polypeptide binding]; other site
434923002980	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
434923002981	dimerization domain swap beta strand [polypeptide binding]; other site
434923002982	regulatory protein interface [polypeptide binding]; other site
434923002983	active site
434923002984	regulatory phosphorylation site [posttranslational modification]; other site
434923002985	peptidase PmbA; Provisional; Region: PRK11040
434923002986	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
434923002987	Found in ATP-dependent protease La (LON); Region: LON; smart00464
434923002988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923002989	Walker A motif; other site
434923002990	ATP binding site [chemical binding]; other site
434923002991	Walker B motif; other site
434923002992	arginine finger; other site
434923002993	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
434923002994	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
434923002995	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
434923002996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923002997	Walker A motif; other site
434923002998	ATP binding site [chemical binding]; other site
434923002999	Walker B motif; other site
434923003000	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
434923003001	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
434923003002	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
434923003003	oligomer interface [polypeptide binding]; other site
434923003004	active site residues [active]
434923003005	trigger factor; Provisional; Region: tig; PRK01490
434923003006	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
434923003007	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
434923003008	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
434923003009	Protein of unknown function (DUF330); Region: DUF330; cl01135
434923003010	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
434923003011	mce related protein; Region: MCE; pfam02470
434923003012	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
434923003013	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
434923003014	Walker A/P-loop; other site
434923003015	ATP binding site [chemical binding]; other site
434923003016	Q-loop/lid; other site
434923003017	ABC transporter signature motif; other site
434923003018	Walker B; other site
434923003019	D-loop; other site
434923003020	H-loop/switch region; other site
434923003021	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
434923003022	anti sigma factor interaction site; other site
434923003023	regulatory phosphorylation site [posttranslational modification]; other site
434923003024	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
434923003025	Permease; Region: Permease; pfam02405
434923003026	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
434923003027	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
434923003028	dimer interface [polypeptide binding]; other site
434923003029	active site
434923003030	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
434923003031	catalytic residues [active]
434923003032	substrate binding site [chemical binding]; other site
434923003033	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
434923003034	deoxyhypusine synthase; Region: dhys; TIGR00321
434923003035	agmatinase; Region: agmatinase; TIGR01230
434923003036	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
434923003037	putative active site [active]
434923003038	Mn binding site [ion binding]; other site
434923003039	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
434923003040	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
434923003041	phosphate:H+ symporter; Region: 2A0109; TIGR00887
434923003042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003043	putative substrate translocation pore; other site
434923003044	response regulator; Provisional; Region: PRK09483
434923003045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923003046	active site
434923003047	phosphorylation site [posttranslational modification]
434923003048	intermolecular recognition site; other site
434923003049	dimerization interface [polypeptide binding]; other site
434923003050	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
434923003051	DNA binding residues [nucleotide binding]
434923003052	dimerization interface [polypeptide binding]; other site
434923003053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
434923003054	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
434923003055	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
434923003056	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
434923003057	Walker A/P-loop; other site
434923003058	ATP binding site [chemical binding]; other site
434923003059	Q-loop/lid; other site
434923003060	ABC transporter signature motif; other site
434923003061	Walker B; other site
434923003062	D-loop; other site
434923003063	H-loop/switch region; other site
434923003064	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
434923003065	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
434923003066	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
434923003067	classical (c) SDRs; Region: SDR_c; cd05233
434923003068	NAD(P) binding site [chemical binding]; other site
434923003069	active site
434923003070	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
434923003071	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
434923003072	active site
434923003073	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
434923003074	ATP-sulfurylase; Region: ATPS; cd00517
434923003075	active site
434923003076	HXXH motif; other site
434923003077	flexible loop; other site
434923003078	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
434923003079	ligand-binding site [chemical binding]; other site
434923003080	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
434923003081	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
434923003082	inhibitor-cofactor binding pocket; inhibition site
434923003083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923003084	catalytic residue [active]
434923003085	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
434923003086	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
434923003087	inhibitor-cofactor binding pocket; inhibition site
434923003088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923003089	catalytic residue [active]
434923003090	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
434923003091	active site
434923003092	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
434923003093	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
434923003094	tetramer interface [polypeptide binding]; other site
434923003095	TPP-binding site [chemical binding]; other site
434923003096	heterodimer interface [polypeptide binding]; other site
434923003097	phosphorylation loop region [posttranslational modification]
434923003098	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
434923003099	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
434923003100	alpha subunit interface [polypeptide binding]; other site
434923003101	TPP binding site [chemical binding]; other site
434923003102	heterodimer interface [polypeptide binding]; other site
434923003103	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
434923003104	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
434923003105	Methyltransferase domain; Region: Methyltransf_23; pfam13489
434923003106	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
434923003107	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
434923003108	active site
434923003109	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
434923003110	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
434923003111	NADP-binding site; other site
434923003112	homotetramer interface [polypeptide binding]; other site
434923003113	substrate binding site [chemical binding]; other site
434923003114	homodimer interface [polypeptide binding]; other site
434923003115	active site
434923003116	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
434923003117	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
434923003118	NADP binding site [chemical binding]; other site
434923003119	active site
434923003120	putative substrate binding site [chemical binding]; other site
434923003121	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
434923003122	Methyltransferase domain; Region: Methyltransf_31; pfam13847
434923003123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923003124	S-adenosylmethionine binding site [chemical binding]; other site
434923003125	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
434923003126	extended (e) SDRs; Region: SDR_e; cd08946
434923003127	NAD(P) binding site [chemical binding]; other site
434923003128	active site
434923003129	substrate binding site [chemical binding]; other site
434923003130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923003131	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
434923003132	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
434923003133	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
434923003134	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
434923003135	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
434923003136	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
434923003137	N-terminal domain of RfaE; Region: RfaE_N; cd02172
434923003138	putative active site [active]
434923003139	(T/H)XGH motif; other site
434923003140	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
434923003141	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
434923003142	putative ribose interaction site [chemical binding]; other site
434923003143	putative ADP binding site [chemical binding]; other site
434923003144	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
434923003145	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923003146	NAD(P) binding site [chemical binding]; other site
434923003147	active site
434923003148	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
434923003149	extended (e) SDRs; Region: SDR_e; cd08946
434923003150	NAD(P) binding site [chemical binding]; other site
434923003151	active site
434923003152	substrate binding site [chemical binding]; other site
434923003153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
434923003154	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
434923003155	active site
434923003156	intersubunit interactions; other site
434923003157	catalytic residue [active]
434923003158	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
434923003159	dimer interface [polypeptide binding]; other site
434923003160	active site
434923003161	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
434923003162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923003163	active site
434923003164	motif I; other site
434923003165	motif II; other site
434923003166	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
434923003167	motif II; other site
434923003168	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
434923003169	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
434923003170	Substrate binding site; other site
434923003171	Cupin domain; Region: Cupin_2; cl17218
434923003172	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
434923003173	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
434923003174	ATP binding site [chemical binding]; other site
434923003175	Mg++ binding site [ion binding]; other site
434923003176	motif III; other site
434923003177	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
434923003178	nucleotide binding region [chemical binding]; other site
434923003179	ATP-binding site [chemical binding]; other site
434923003180	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
434923003181	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
434923003182	trimer interface [polypeptide binding]; other site
434923003183	active site
434923003184	substrate binding site [chemical binding]; other site
434923003185	CoA binding site [chemical binding]; other site
434923003186	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
434923003187	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
434923003188	metal binding site [ion binding]; metal-binding site
434923003189	dimer interface [polypeptide binding]; other site
434923003190	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
434923003191	Transposase [DNA replication, recombination, and repair]; Region: COG5433
434923003192	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
434923003193	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
434923003194	AAA domain; Region: AAA_14; pfam13173
434923003195	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
434923003196	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14958
434923003197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923003198	Walker A motif; other site
434923003199	ATP binding site [chemical binding]; other site
434923003200	Walker B motif; other site
434923003201	arginine finger; other site
434923003202	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
434923003203	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
434923003204	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
434923003205	recombination protein RecR; Reviewed; Region: recR; PRK00076
434923003206	RecR protein; Region: RecR; pfam02132
434923003207	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
434923003208	putative active site [active]
434923003209	putative metal-binding site [ion binding]; other site
434923003210	tetramer interface [polypeptide binding]; other site
434923003211	hypothetical protein; Validated; Region: PRK00153
434923003212	Domain of unknown function DUF20; Region: UPF0118; pfam01594
434923003213	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
434923003214	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
434923003215	homopentamer interface [polypeptide binding]; other site
434923003216	active site
434923003217	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
434923003218	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
434923003219	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
434923003220	dimerization interface [polypeptide binding]; other site
434923003221	active site
434923003222	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
434923003223	Lumazine binding domain; Region: Lum_binding; pfam00677
434923003224	Lumazine binding domain; Region: Lum_binding; pfam00677
434923003225	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
434923003226	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
434923003227	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
434923003228	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
434923003229	catalytic motif [active]
434923003230	Zn binding site [ion binding]; other site
434923003231	RibD C-terminal domain; Region: RibD_C; cl17279
434923003232	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
434923003233	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
434923003234	putative active site [active]
434923003235	catalytic site [active]
434923003236	putative metal binding site [ion binding]; other site
434923003237	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
434923003238	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
434923003239	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
434923003240	NAD binding site [chemical binding]; other site
434923003241	Phe binding site; other site
434923003242	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
434923003243	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
434923003244	TPP-binding site [chemical binding]; other site
434923003245	tetramer interface [polypeptide binding]; other site
434923003246	heterodimer interface [polypeptide binding]; other site
434923003247	phosphorylation loop region [posttranslational modification]
434923003248	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
434923003249	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
434923003250	alpha subunit interface [polypeptide binding]; other site
434923003251	TPP binding site [chemical binding]; other site
434923003252	heterodimer interface [polypeptide binding]; other site
434923003253	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
434923003254	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
434923003255	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
434923003256	E3 interaction surface; other site
434923003257	lipoyl attachment site [posttranslational modification]; other site
434923003258	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
434923003259	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
434923003260	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
434923003261	EamA-like transporter family; Region: EamA; pfam00892
434923003262	PAS domain; Region: PAS; smart00091
434923003263	PAS domain; Region: PAS_9; pfam13426
434923003264	putative active site [active]
434923003265	heme pocket [chemical binding]; other site
434923003266	PAS fold; Region: PAS_4; pfam08448
434923003267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
434923003268	putative active site [active]
434923003269	heme pocket [chemical binding]; other site
434923003270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923003271	dimer interface [polypeptide binding]; other site
434923003272	phosphorylation site [posttranslational modification]
434923003273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923003274	ATP binding site [chemical binding]; other site
434923003275	Mg2+ binding site [ion binding]; other site
434923003276	G-X-G motif; other site
434923003277	Response regulator receiver domain; Region: Response_reg; pfam00072
434923003278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923003279	active site
434923003280	phosphorylation site [posttranslational modification]
434923003281	intermolecular recognition site; other site
434923003282	dimerization interface [polypeptide binding]; other site
434923003283	Uncharacterized conserved protein [Function unknown]; Region: COG3461
434923003284	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
434923003285	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
434923003286	dimerization interface [polypeptide binding]; other site
434923003287	ATP binding site [chemical binding]; other site
434923003288	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
434923003289	dimerization interface [polypeptide binding]; other site
434923003290	ATP binding site [chemical binding]; other site
434923003291	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
434923003292	putative active site [active]
434923003293	catalytic triad [active]
434923003294	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
434923003295	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
434923003296	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
434923003297	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
434923003298	Proline dehydrogenase; Region: Pro_dh; pfam01619
434923003299	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
434923003300	Glutamate binding site [chemical binding]; other site
434923003301	NAD binding site [chemical binding]; other site
434923003302	catalytic residues [active]
434923003303	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
434923003304	dimer interface [polypeptide binding]; other site
434923003305	substrate binding site [chemical binding]; other site
434923003306	metal binding sites [ion binding]; metal-binding site
434923003307	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
434923003308	nucleoside/Zn binding site; other site
434923003309	dimer interface [polypeptide binding]; other site
434923003310	catalytic motif [active]
434923003311	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
434923003312	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
434923003313	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
434923003314	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
434923003315	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
434923003316	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
434923003317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
434923003318	active site
434923003319	motif I; other site
434923003320	motif II; other site
434923003321	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
434923003322	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
434923003323	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
434923003324	active site
434923003325	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
434923003326	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
434923003327	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
434923003328	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
434923003329	trimer interface [polypeptide binding]; other site
434923003330	active site
434923003331	UDP-GlcNAc binding site [chemical binding]; other site
434923003332	lipid binding site [chemical binding]; lipid-binding site
434923003333	periplasmic chaperone; Provisional; Region: PRK10780
434923003334	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
434923003335	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
434923003336	homodimer interface [polypeptide binding]; other site
434923003337	substrate binding pocket [chemical binding]; other site
434923003338	catalytic residues [active]
434923003339	NADH/NADPH cofactor binding site [chemical binding]; other site
434923003340	mevalonate kinase; Region: mevalon_kin; TIGR00549
434923003341	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
434923003342	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
434923003343	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
434923003344	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
434923003345	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
434923003346	diphosphomevalonate decarboxylase; Region: PLN02407
434923003347	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
434923003348	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
434923003349	active site
434923003350	metal binding site [ion binding]; metal-binding site
434923003351	nudix motif; other site
434923003352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923003353	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923003354	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923003355	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
434923003356	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
434923003357	active site
434923003358	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
434923003359	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
434923003360	dimer interface [polypeptide binding]; other site
434923003361	ADP-ribose binding site [chemical binding]; other site
434923003362	active site
434923003363	nudix motif; other site
434923003364	metal binding site [ion binding]; metal-binding site
434923003365	HemN family oxidoreductase; Provisional; Region: PRK05660
434923003366	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923003367	FeS/SAM binding site; other site
434923003368	HemN C-terminal domain; Region: HemN_C; pfam06969
434923003369	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
434923003370	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
434923003371	dimer interface [polypeptide binding]; other site
434923003372	[2Fe-2S] cluster binding site [ion binding]; other site
434923003373	quinolinate synthetase; Provisional; Region: PRK09375
434923003374	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
434923003375	active site residue [active]
434923003376	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
434923003377	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
434923003378	FAD binding pocket [chemical binding]; other site
434923003379	FAD binding motif [chemical binding]; other site
434923003380	phosphate binding motif [ion binding]; other site
434923003381	beta-alpha-beta structure motif; other site
434923003382	NAD binding pocket [chemical binding]; other site
434923003383	Iron coordination center [ion binding]; other site
434923003384	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
434923003385	putative GSH binding site [chemical binding]; other site
434923003386	catalytic residues [active]
434923003387	BolA-like protein; Region: BolA; pfam01722
434923003388	Ferredoxin [Energy production and conversion]; Region: COG1146
434923003389	4Fe-4S binding domain; Region: Fer4; pfam00037
434923003390	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
434923003391	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
434923003392	putative active site [active]
434923003393	YdjC motif; other site
434923003394	Mg binding site [ion binding]; other site
434923003395	putative homodimer interface [polypeptide binding]; other site
434923003396	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
434923003397	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
434923003398	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
434923003399	Ligand binding site; other site
434923003400	Putative Catalytic site; other site
434923003401	DXD motif; other site
434923003402	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
434923003403	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
434923003404	substrate binding site [chemical binding]; other site
434923003405	oxyanion hole (OAH) forming residues; other site
434923003406	trimer interface [polypeptide binding]; other site
434923003407	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
434923003408	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
434923003409	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
434923003410	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
434923003411	dimer interface [polypeptide binding]; other site
434923003412	active site
434923003413	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923003414	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
434923003415	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
434923003416	active site
434923003417	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
434923003418	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
434923003419	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
434923003420	interface (dimer of trimers) [polypeptide binding]; other site
434923003421	Substrate-binding/catalytic site; other site
434923003422	Zn-binding sites [ion binding]; other site
434923003423	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
434923003424	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
434923003425	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
434923003426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
434923003427	FeS/SAM binding site; other site
434923003428	TRAM domain; Region: TRAM; pfam01938
434923003429	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
434923003430	PhoH-like protein; Region: PhoH; pfam02562
434923003431	metal-binding heat shock protein; Provisional; Region: PRK00016
434923003432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003433	putative substrate translocation pore; other site
434923003434	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923003435	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
434923003436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
434923003437	Transporter associated domain; Region: CorC_HlyC; smart01091
434923003438	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
434923003439	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
434923003440	putative active site [active]
434923003441	catalytic triad [active]
434923003442	putative dimer interface [polypeptide binding]; other site
434923003443	Phytochelatin synthase; Region: Phytochelatin; pfam05023
434923003444	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
434923003445	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
434923003446	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
434923003447	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
434923003448	HIGH motif; other site
434923003449	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
434923003450	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
434923003451	active site
434923003452	KMSKS motif; other site
434923003453	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
434923003454	tRNA binding surface [nucleotide binding]; other site
434923003455	Lipopolysaccharide-assembly; Region: LptE; cl01125
434923003456	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
434923003457	DNA polymerase III, delta subunit; Region: holA; TIGR01128
434923003458	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
434923003459	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
434923003460	active site
434923003461	(T/H)XGH motif; other site
434923003462	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
434923003463	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
434923003464	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
434923003465	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
434923003466	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
434923003467	Transglycosylase SLT domain; Region: SLT_2; pfam13406
434923003468	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
434923003469	N-acetyl-D-glucosamine binding site [chemical binding]; other site
434923003470	Tetratricopeptide repeat; Region: TPR_16; pfam13432
434923003471	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923003472	binding surface
434923003473	TPR motif; other site
434923003474	TPR repeat; Region: TPR_11; pfam13414
434923003475	TPR repeat; Region: TPR_11; pfam13414
434923003476	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923003477	binding surface
434923003478	TPR motif; other site
434923003479	TPR repeat; Region: TPR_11; pfam13414
434923003480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923003481	binding surface
434923003482	TPR motif; other site
434923003483	TPR repeat; Region: TPR_11; pfam13414
434923003484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923003485	binding surface
434923003486	TPR motif; other site
434923003487	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
434923003488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
434923003489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923003490	S-adenosylmethionine binding site [chemical binding]; other site
434923003491	heat shock protein HtpX; Provisional; Region: PRK02870
434923003492	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
434923003493	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
434923003494	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
434923003495	nucleotide binding pocket [chemical binding]; other site
434923003496	K-X-D-G motif; other site
434923003497	catalytic site [active]
434923003498	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
434923003499	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
434923003500	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
434923003501	Dimer interface [polypeptide binding]; other site
434923003502	BRCT sequence motif; other site
434923003503	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
434923003504	FtsZ protein binding site [polypeptide binding]; other site
434923003505	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
434923003506	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
434923003507	Walker A/P-loop; other site
434923003508	ATP binding site [chemical binding]; other site
434923003509	Q-loop/lid; other site
434923003510	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
434923003511	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
434923003512	ABC transporter signature motif; other site
434923003513	Walker B; other site
434923003514	D-loop; other site
434923003515	H-loop/switch region; other site
434923003516	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
434923003517	POT family; Region: PTR2; cl17359
434923003518	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
434923003519	Sel1-like repeats; Region: SEL1; smart00671
434923003520	cell division protein DamX; Validated; Region: PRK10905
434923003521	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
434923003522	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
434923003523	Mg++ binding site [ion binding]; other site
434923003524	putative catalytic motif [active]
434923003525	substrate binding site [chemical binding]; other site
434923003526	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
434923003527	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
434923003528	active site
434923003529	dimer interface [polypeptide binding]; other site
434923003530	tetratricopeptide repeat protein; Provisional; Region: PRK11788
434923003531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923003532	binding surface
434923003533	TPR motif; other site
434923003534	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923003535	binding surface
434923003536	TPR motif; other site
434923003537	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923003538	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
434923003539	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
434923003540	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
434923003541	RNA binding site [nucleotide binding]; other site
434923003542	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
434923003543	RNA binding site [nucleotide binding]; other site
434923003544	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
434923003545	RNA binding site [nucleotide binding]; other site
434923003546	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
434923003547	RNA binding site [nucleotide binding]; other site
434923003548	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
434923003549	RNA binding site [nucleotide binding]; other site
434923003550	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
434923003551	RNA binding site [nucleotide binding]; other site
434923003552	cytidylate kinase; Provisional; Region: cmk; PRK00023
434923003553	AAA domain; Region: AAA_17; pfam13207
434923003554	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
434923003555	CMP-binding site; other site
434923003556	The sites determining sugar specificity; other site
434923003557	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
434923003558	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
434923003559	hinge; other site
434923003560	active site
434923003561	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
434923003562	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
434923003563	catalytic residue [active]
434923003564	DNA gyrase subunit A; Validated; Region: PRK05560
434923003565	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
434923003566	CAP-like domain; other site
434923003567	active site
434923003568	primary dimer interface [polypeptide binding]; other site
434923003569	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
434923003570	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
434923003571	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
434923003572	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
434923003573	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
434923003574	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
434923003575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923003576	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923003577	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923003578	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
434923003579	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
434923003580	active site
434923003581	putative substrate binding pocket [chemical binding]; other site
434923003582	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
434923003583	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
434923003584	active site
434923003585	catalytic residues [active]
434923003586	metal binding site [ion binding]; metal-binding site
434923003587	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
434923003588	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
434923003589	excinuclease ABC subunit B; Provisional; Region: PRK05298
434923003590	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
434923003591	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
434923003592	ATP-binding site [chemical binding]; other site
434923003593	ATP binding site [chemical binding]; other site
434923003594	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
434923003595	nucleotide binding region [chemical binding]; other site
434923003596	ATP-binding site [chemical binding]; other site
434923003597	Ultra-violet resistance protein B; Region: UvrB; pfam12344
434923003598	UvrB/uvrC motif; Region: UVR; pfam02151
434923003599	aspartate aminotransferase; Provisional; Region: PRK05764
434923003600	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
434923003601	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923003602	homodimer interface [polypeptide binding]; other site
434923003603	catalytic residue [active]
434923003604	Condensation domain; Region: Condensation; pfam00668
434923003605	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
434923003606	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003607	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003608	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003609	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003610	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003611	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003612	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
434923003613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003614	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923003615	putative substrate translocation pore; other site
434923003616	Ceramidase; Region: Ceramidase; pfam05875
434923003617	Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862
434923003618	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
434923003619	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
434923003620	putative active site [active]
434923003621	Zn binding site [ion binding]; other site
434923003622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003623	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923003624	putative substrate translocation pore; other site
434923003625	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923003626	Trp operon repressor; Provisional; Region: PRK01381
434923003627	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
434923003628	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
434923003629	DHH family; Region: DHH; pfam01368
434923003630	DHHA1 domain; Region: DHHA1; pfam02272
434923003631	similar to hypothetical protein
434923003632	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
434923003633	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
434923003634	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
434923003635	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
434923003636	POT family; Region: PTR2; cl17359
434923003637	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
434923003638	glutamine synthetase; Region: PLN02284
434923003639	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
434923003640	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
434923003641	active site
434923003642	DNA polymerase III subunit delta'; Validated; Region: PRK05707
434923003643	DNA polymerase III subunit delta'; Validated; Region: PRK08485
434923003644	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
434923003645	thymidylate kinase; Validated; Region: tmk; PRK00698
434923003646	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
434923003647	TMP-binding site; other site
434923003648	ATP-binding site [chemical binding]; other site
434923003649	YceG-like family; Region: YceG; pfam02618
434923003650	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
434923003651	dimerization interface [polypeptide binding]; other site
434923003652	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
434923003653	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
434923003654	dimer interface [polypeptide binding]; other site
434923003655	active site
434923003656	acyl carrier protein; Provisional; Region: acpP; PRK00982
434923003657	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
434923003658	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
434923003659	NAD(P) binding site [chemical binding]; other site
434923003660	homotetramer interface [polypeptide binding]; other site
434923003661	homodimer interface [polypeptide binding]; other site
434923003662	active site
434923003663	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
434923003664	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
434923003665	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
434923003666	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
434923003667	dimer interface [polypeptide binding]; other site
434923003668	active site
434923003669	CoA binding pocket [chemical binding]; other site
434923003670	putative phosphate acyltransferase; Provisional; Region: PRK05331
434923003671	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
434923003672	hypothetical protein; Provisional; Region: PRK08609
434923003673	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
434923003674	active site
434923003675	primer binding site [nucleotide binding]; other site
434923003676	NTP  binding site [chemical binding]; other site
434923003677	metal binding triad [ion binding]; metal-binding site
434923003678	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
434923003679	active site
434923003680	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
434923003681	dimerization interface [polypeptide binding]; other site
434923003682	substrate binding site [chemical binding]; other site
434923003683	active site
434923003684	calcium binding site [ion binding]; other site
434923003685	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
434923003686	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
434923003687	active site
434923003688	metal binding site [ion binding]; metal-binding site
434923003689	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
434923003690	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
434923003691	RNA binding surface [nucleotide binding]; other site
434923003692	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
434923003693	active site
434923003694	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
434923003695	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
434923003696	homodimer interface [polypeptide binding]; other site
434923003697	oligonucleotide binding site [chemical binding]; other site
434923003698	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
434923003699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
434923003700	dimer interface [polypeptide binding]; other site
434923003701	conserved gate region; other site
434923003702	putative PBP binding loops; other site
434923003703	ABC-ATPase subunit interface; other site
434923003704	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
434923003705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
434923003706	dimer interface [polypeptide binding]; other site
434923003707	conserved gate region; other site
434923003708	putative PBP binding loops; other site
434923003709	ABC-ATPase subunit interface; other site
434923003710	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
434923003711	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
434923003712	substrate binding pocket [chemical binding]; other site
434923003713	membrane-bound complex binding site; other site
434923003714	hinge residues; other site
434923003715	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
434923003716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
434923003717	Walker A/P-loop; other site
434923003718	ATP binding site [chemical binding]; other site
434923003719	Q-loop/lid; other site
434923003720	ABC transporter signature motif; other site
434923003721	Walker B; other site
434923003722	D-loop; other site
434923003723	H-loop/switch region; other site
434923003724	arginine repressor; Provisional; Region: PRK05066
434923003725	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
434923003726	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
434923003727	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
434923003728	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
434923003729	Ligand binding site; other site
434923003730	oligomer interface; other site
434923003731	Uncharacterized conserved protein [Function unknown]; Region: COG2835
434923003732	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
434923003733	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
434923003734	IHF dimer interface [polypeptide binding]; other site
434923003735	IHF - DNA interface [nucleotide binding]; other site
434923003736	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
434923003737	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
434923003738	ATP binding site [chemical binding]; other site
434923003739	putative Mg++ binding site [ion binding]; other site
434923003740	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
434923003741	nucleotide binding region [chemical binding]; other site
434923003742	ATP-binding site [chemical binding]; other site
434923003743	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
434923003744	HRDC domain; Region: HRDC; pfam00570
434923003745	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
434923003746	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
434923003747	active site
434923003748	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
434923003749	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
434923003750	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
434923003751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923003752	S-adenosylmethionine binding site [chemical binding]; other site
434923003753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
434923003754	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
434923003755	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
434923003756	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
434923003757	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
434923003758	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
434923003759	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
434923003760	E3 interaction surface; other site
434923003761	lipoyl attachment site [posttranslational modification]; other site
434923003762	e3 binding domain; Region: E3_binding; pfam02817
434923003763	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
434923003764	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
434923003765	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
434923003766	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
434923003767	dimer interface [polypeptide binding]; other site
434923003768	TPP-binding site [chemical binding]; other site
434923003769	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
434923003770	CobD/Cbib protein; Region: CobD_Cbib; cl00561
434923003771	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
434923003772	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
434923003773	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
434923003774	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
434923003775	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
434923003776	catalytic residues [active]
434923003777	adenylate kinase; Reviewed; Region: adk; PRK00279
434923003778	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
434923003779	AMP-binding site [chemical binding]; other site
434923003780	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
434923003781	Type II transport protein GspH; Region: GspH; pfam12019
434923003782	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
434923003783	Domain of unknown function DUF21; Region: DUF21; pfam01595
434923003784	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
434923003785	Transporter associated domain; Region: CorC_HlyC; smart01091
434923003786	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
434923003787	signal recognition particle protein; Provisional; Region: PRK10867
434923003788	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
434923003789	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
434923003790	P loop; other site
434923003791	GTP binding site [chemical binding]; other site
434923003792	Signal peptide binding domain; Region: SRP_SPB; pfam02978
434923003793	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
434923003794	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003795	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003796	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
434923003797	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003798	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14523
434923003799	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
434923003800	RimM N-terminal domain; Region: RimM; pfam01782
434923003801	PRC-barrel domain; Region: PRC; pfam05239
434923003802	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
434923003803	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
434923003804	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
434923003805	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
434923003806	DNA binding site [nucleotide binding]
434923003807	active site
434923003808	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923003809	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
434923003810	Mechanosensitive ion channel; Region: MS_channel; pfam00924
434923003811	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
434923003812	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
434923003813	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
434923003814	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
434923003815	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
434923003816	dimer interface [polypeptide binding]; other site
434923003817	putative anticodon binding site; other site
434923003818	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
434923003819	motif 1; other site
434923003820	active site
434923003821	motif 2; other site
434923003822	motif 3; other site
434923003823	hypothetical protein; Provisional; Region: PRK09256
434923003824	This domain is found in peptide chain release factors; Region: PCRF; smart00937
434923003825	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
434923003826	RF-1 domain; Region: RF-1; pfam00472
434923003827	amino acid transporter; Region: 2A0306; TIGR00909
434923003828	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
434923003829	oligomerization interface [polypeptide binding]; other site
434923003830	active site
434923003831	metal binding site [ion binding]; metal-binding site
434923003832	pantoate--beta-alanine ligase; Region: panC; TIGR00018
434923003833	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
434923003834	active site
434923003835	nucleotide binding site [chemical binding]; other site
434923003836	HIGH motif; other site
434923003837	KMSKS motif; other site
434923003838	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
434923003839	tetramerization interface [polypeptide binding]; other site
434923003840	active site
434923003841	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
434923003842	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
434923003843	NodB motif; other site
434923003844	putative active site [active]
434923003845	putative catalytic site [active]
434923003846	putative Zn binding site [ion binding]; other site
434923003847	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
434923003848	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
434923003849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923003850	catalytic residue [active]
434923003851	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
434923003852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923003853	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923003854	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923003855	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
434923003856	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
434923003857	lipoprotein signal peptidase; Provisional; Region: PRK14787
434923003858	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
434923003859	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
434923003860	active site
434923003861	HIGH motif; other site
434923003862	nucleotide binding site [chemical binding]; other site
434923003863	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
434923003864	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
434923003865	active site
434923003866	KMSKS motif; other site
434923003867	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
434923003868	tRNA binding surface [nucleotide binding]; other site
434923003869	anticodon binding site; other site
434923003870	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
434923003871	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
434923003872	similar to hypothetical protein
434923003873	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
434923003874	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
434923003875	active site
434923003876	Riboflavin kinase; Region: Flavokinase; smart00904
434923003877	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
434923003878	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
434923003879	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
434923003880	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
434923003881	GTP1/OBG; Region: GTP1_OBG; pfam01018
434923003882	Obg GTPase; Region: Obg; cd01898
434923003883	G1 box; other site
434923003884	GTP/Mg2+ binding site [chemical binding]; other site
434923003885	Switch I region; other site
434923003886	G2 box; other site
434923003887	G3 box; other site
434923003888	Switch II region; other site
434923003889	G4 box; other site
434923003890	G5 box; other site
434923003891	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
434923003892	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
434923003893	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
434923003894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923003895	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923003896	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923003897	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
434923003898	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
434923003899	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
434923003900	substrate binding pocket [chemical binding]; other site
434923003901	chain length determination region; other site
434923003902	substrate-Mg2+ binding site; other site
434923003903	catalytic residues [active]
434923003904	aspartate-rich region 1; other site
434923003905	active site lid residues [active]
434923003906	aspartate-rich region 2; other site
434923003907	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
434923003908	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
434923003909	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
434923003910	amidase catalytic site [active]
434923003911	Zn binding residues [ion binding]; other site
434923003912	substrate binding site [chemical binding]; other site
434923003913	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
434923003914	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
434923003915	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
434923003916	putative active site [active]
434923003917	putative catalytic site [active]
434923003918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003919	putative substrate translocation pore; other site
434923003920	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
434923003921	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
434923003922	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
434923003923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923003924	active site
434923003925	phosphorylation site [posttranslational modification]
434923003926	intermolecular recognition site; other site
434923003927	dimerization interface [polypeptide binding]; other site
434923003928	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
434923003929	DNA binding site [nucleotide binding]
434923003930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923003931	dimer interface [polypeptide binding]; other site
434923003932	phosphorylation site [posttranslational modification]
434923003933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923003934	ATP binding site [chemical binding]; other site
434923003935	Mg2+ binding site [ion binding]; other site
434923003936	G-X-G motif; other site
434923003937	phosphate:H+ symporter; Region: 2A0109; TIGR00887
434923003938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003939	putative substrate translocation pore; other site
434923003940	Peptidase family U32; Region: Peptidase_U32; cl03113
434923003941	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
434923003942	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
434923003943	metal binding site [ion binding]; metal-binding site
434923003944	dimer interface [polypeptide binding]; other site
434923003945	F-box domain; Region: F-box; pfam00646
434923003946	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003947	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003948	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003949	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923003950	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003951	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
434923003952	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
434923003953	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923003954	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
434923003955	amino acid transporter; Region: 2A0306; TIGR00909
434923003956	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
434923003957	putative inner membrane peptidase; Provisional; Region: PRK11778
434923003958	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
434923003959	tandem repeat interface [polypeptide binding]; other site
434923003960	oligomer interface [polypeptide binding]; other site
434923003961	active site residues [active]
434923003962	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
434923003963	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
434923003964	putative binding surface; other site
434923003965	active site
434923003966	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
434923003967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923003968	S-adenosylmethionine binding site [chemical binding]; other site
434923003969	phosphoglycolate phosphatase; Provisional; Region: PRK13226
434923003970	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923003971	motif II; other site
434923003972	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
434923003973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923003975	xylose isomerase; Provisional; Region: PRK05474
434923003976	xylose isomerase; Region: xylose_isom_A; TIGR02630
434923003977	6-phosphofructokinase; Provisional; Region: PRK03202
434923003978	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
434923003979	active site
434923003980	ADP/pyrophosphate binding site [chemical binding]; other site
434923003981	dimerization interface [polypeptide binding]; other site
434923003982	allosteric effector site; other site
434923003983	fructose-1,6-bisphosphate binding site; other site
434923003984	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
434923003985	aminopeptidase N; Provisional; Region: pepN; PRK14015
434923003986	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
434923003987	active site
434923003988	Zn binding site [ion binding]; other site
434923003989	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
434923003990	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
434923003991	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
434923003992	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
434923003993	purine monophosphate binding site [chemical binding]; other site
434923003994	dimer interface [polypeptide binding]; other site
434923003995	putative catalytic residues [active]
434923003996	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
434923003997	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
434923003998	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767
434923003999	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
434923004000	dimer interface [polypeptide binding]; other site
434923004001	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
434923004002	substrate binding site [chemical binding]; other site
434923004003	ATP binding site [chemical binding]; other site
434923004004	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
434923004005	thiamine phosphate binding site [chemical binding]; other site
434923004006	active site
434923004007	pyrophosphate binding site [ion binding]; other site
434923004008	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
434923004009	ThiS interaction site; other site
434923004010	putative active site [active]
434923004011	tetramer interface [polypeptide binding]; other site
434923004012	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
434923004013	thiS-thiF/thiG interaction site; other site
434923004014	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
434923004015	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
434923004016	ThiC-associated domain; Region: ThiC-associated; pfam13667
434923004017	ThiC family; Region: ThiC; pfam01964
434923004018	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
434923004019	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
434923004020	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
434923004021	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
434923004022	acyl-CoA synthetase; Validated; Region: PRK05850
434923004023	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
434923004024	acyl-activating enzyme (AAE) consensus motif; other site
434923004025	active site
434923004026	Phosphopantetheine attachment site; Region: PP-binding; cl09936
434923004027	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
434923004028	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
434923004029	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
434923004030	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923004031	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
434923004032	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
434923004033	active site
434923004034	catalytic site [active]
434923004035	substrate binding site [chemical binding]; other site
434923004036	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
434923004037	RNA/DNA hybrid binding site [nucleotide binding]; other site
434923004038	active site
434923004039	Methyltransferase domain; Region: Methyltransf_23; pfam13489
434923004040	Methyltransferase domain; Region: Methyltransf_11; pfam08241
434923004041	DNA methylase; Region: N6_N4_Mtase; cl17433
434923004042	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
434923004043	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
434923004044	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
434923004045	N-acetyl-D-glucosamine binding site [chemical binding]; other site
434923004046	catalytic residue [active]
434923004047	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
434923004048	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
434923004049	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
434923004050	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
434923004051	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923004052	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
434923004053	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
434923004054	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
434923004055	homodimer interface [polypeptide binding]; other site
434923004056	NADP binding site [chemical binding]; other site
434923004057	substrate binding site [chemical binding]; other site
434923004058	heat shock protein 90; Provisional; Region: PRK05218
434923004059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923004060	ATP binding site [chemical binding]; other site
434923004061	Mg2+ binding site [ion binding]; other site
434923004062	G-X-G motif; other site
434923004063	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
434923004064	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
434923004065	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
434923004066	generic binding surface II; other site
434923004067	ssDNA binding site; other site
434923004068	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
434923004069	ATP binding site [chemical binding]; other site
434923004070	putative Mg++ binding site [ion binding]; other site
434923004071	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
434923004072	nucleotide binding region [chemical binding]; other site
434923004073	ATP-binding site [chemical binding]; other site
434923004074	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
434923004075	homotrimer interaction site [polypeptide binding]; other site
434923004076	putative active site [active]
434923004077	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
434923004078	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
434923004079	Zn2+ binding site [ion binding]; other site
434923004080	Mg2+ binding site [ion binding]; other site
434923004081	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
434923004082	synthetase active site [active]
434923004083	NTP binding site [chemical binding]; other site
434923004084	metal binding site [ion binding]; metal-binding site
434923004085	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
434923004086	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
434923004087	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
434923004088	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
434923004089	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
434923004090	catalytic site [active]
434923004091	G-X2-G-X-G-K; other site
434923004092	hypothetical protein; Provisional; Region: PRK11820
434923004093	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
434923004094	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
434923004095	ribonuclease PH; Reviewed; Region: rph; PRK00173
434923004096	Ribonuclease PH; Region: RNase_PH_bact; cd11362
434923004097	hexamer interface [polypeptide binding]; other site
434923004098	active site
434923004099	glutamate racemase; Provisional; Region: PRK00865
434923004100	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
434923004101	putative active site [active]
434923004102	putative catalytic site [active]
434923004103	putative DNA binding site [nucleotide binding]; other site
434923004104	putative phosphate binding site [ion binding]; other site
434923004105	metal binding site A [ion binding]; metal-binding site
434923004106	putative AP binding site [nucleotide binding]; other site
434923004107	putative metal binding site B [ion binding]; other site
434923004108	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
434923004109	active site
434923004110	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
434923004111	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
434923004112	active site
434923004113	substrate binding site [chemical binding]; other site
434923004114	metal binding site [ion binding]; metal-binding site
434923004115	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
434923004116	trimer interface [polypeptide binding]; other site
434923004117	active site
434923004118	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
434923004119	MPN+ (JAMM) motif; other site
434923004120	Zinc-binding site [ion binding]; other site
434923004121	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
434923004122	Ribosomal protein L33; Region: Ribosomal_L33; pfam00471
434923004123	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
434923004124	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
434923004125	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
434923004126	active site
434923004127	(T/H)XGH motif; other site
434923004128	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
434923004129	catalytic center binding site [active]
434923004130	ATP binding site [chemical binding]; other site
434923004131	poly(A) polymerase; Region: pcnB; TIGR01942
434923004132	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
434923004133	active site
434923004134	NTP binding site [chemical binding]; other site
434923004135	metal binding triad [ion binding]; metal-binding site
434923004136	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
434923004137	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
434923004138	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
434923004139	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
434923004140	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
434923004141	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
434923004142	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
434923004143	active site
434923004144	DNA polymerase IV; Validated; Region: PRK02406
434923004145	DNA binding site [nucleotide binding]
434923004146	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
434923004147	Amidinotransferase; Region: Amidinotransf; pfam02274
434923004148	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
434923004149	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
434923004150	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
434923004151	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
434923004152	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
434923004153	substrate binding site [chemical binding]; other site
434923004154	active site
434923004155	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
434923004156	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
434923004157	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
434923004158	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
434923004159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004160	Major Facilitator Superfamily; Region: MFS_1; pfam07690
434923004161	putative substrate translocation pore; other site
434923004162	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
434923004163	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
434923004164	dimer interface [polypeptide binding]; other site
434923004165	ssDNA binding site [nucleotide binding]; other site
434923004166	tetramer (dimer of dimers) interface [polypeptide binding]; other site
434923004167	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
434923004168	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
434923004169	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
434923004170	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
434923004171	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
434923004172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004173	putative substrate translocation pore; other site
434923004174	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
434923004175	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
434923004176	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
434923004177	alphaNTD homodimer interface [polypeptide binding]; other site
434923004178	alphaNTD - beta interaction site [polypeptide binding]; other site
434923004179	alphaNTD - beta' interaction site [polypeptide binding]; other site
434923004180	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
434923004181	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
434923004182	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
434923004183	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
434923004184	RNA binding surface [nucleotide binding]; other site
434923004185	30S ribosomal protein S11; Validated; Region: PRK05309
434923004186	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
434923004187	30S ribosomal protein S13; Region: bact_S13; TIGR03631
434923004188	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
434923004189	SecY translocase; Region: SecY; pfam00344
434923004190	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
434923004191	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
434923004192	23S rRNA binding site [nucleotide binding]; other site
434923004193	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
434923004194	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
434923004195	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
434923004196	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
434923004197	5S rRNA interface [nucleotide binding]; other site
434923004198	23S rRNA interface [nucleotide binding]; other site
434923004199	L5 interface [polypeptide binding]; other site
434923004200	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
434923004201	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
434923004202	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
434923004203	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
434923004204	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
434923004205	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
434923004206	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
434923004207	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
434923004208	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
434923004209	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
434923004210	RNA binding site [nucleotide binding]; other site
434923004211	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
434923004212	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
434923004213	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
434923004214	L23 interface [polypeptide binding]; other site
434923004215	signal recognition particle (SRP54) interaction site; other site
434923004216	trigger factor interaction site; other site
434923004217	23S rRNA interface [nucleotide binding]; other site
434923004218	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
434923004219	23S rRNA interface [nucleotide binding]; other site
434923004220	5S rRNA interface [nucleotide binding]; other site
434923004221	putative antibiotic binding site [chemical binding]; other site
434923004222	L25 interface [polypeptide binding]; other site
434923004223	L27 interface [polypeptide binding]; other site
434923004224	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
434923004225	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
434923004226	G-X-X-G motif; other site
434923004227	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
434923004228	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
434923004229	protein-rRNA interface [nucleotide binding]; other site
434923004230	putative translocon binding site; other site
434923004231	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
434923004232	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
434923004233	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
434923004234	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
434923004235	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
434923004236	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
434923004237	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
434923004238	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
434923004239	elongation factor Tu; Reviewed; Region: PRK00049
434923004240	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
434923004241	G1 box; other site
434923004242	GEF interaction site [polypeptide binding]; other site
434923004243	GTP/Mg2+ binding site [chemical binding]; other site
434923004244	Switch I region; other site
434923004245	G2 box; other site
434923004246	G3 box; other site
434923004247	Switch II region; other site
434923004248	G4 box; other site
434923004249	G5 box; other site
434923004250	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
434923004251	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
434923004252	Antibiotic Binding Site [chemical binding]; other site
434923004253	elongation factor G; Reviewed; Region: PRK00007
434923004254	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
434923004255	G1 box; other site
434923004256	putative GEF interaction site [polypeptide binding]; other site
434923004257	GTP/Mg2+ binding site [chemical binding]; other site
434923004258	Switch I region; other site
434923004259	G2 box; other site
434923004260	G3 box; other site
434923004261	Switch II region; other site
434923004262	G4 box; other site
434923004263	G5 box; other site
434923004264	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
434923004265	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
434923004266	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
434923004267	30S ribosomal protein S7; Validated; Region: PRK05302
434923004268	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
434923004269	S17 interaction site [polypeptide binding]; other site
434923004270	S8 interaction site; other site
434923004271	16S rRNA interaction site [nucleotide binding]; other site
434923004272	streptomycin interaction site [chemical binding]; other site
434923004273	23S rRNA interaction site [nucleotide binding]; other site
434923004274	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
434923004275	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
434923004276	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
434923004277	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
434923004278	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
434923004279	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
434923004280	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
434923004281	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
434923004282	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
434923004283	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
434923004284	DNA binding site [nucleotide binding]
434923004285	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
434923004286	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
434923004287	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
434923004288	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
434923004289	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
434923004290	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
434923004291	RPB12 interaction site [polypeptide binding]; other site
434923004292	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
434923004293	RPB3 interaction site [polypeptide binding]; other site
434923004294	RPB1 interaction site [polypeptide binding]; other site
434923004295	RPB11 interaction site [polypeptide binding]; other site
434923004296	RPB10 interaction site [polypeptide binding]; other site
434923004297	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
434923004298	core dimer interface [polypeptide binding]; other site
434923004299	peripheral dimer interface [polypeptide binding]; other site
434923004300	L10 interface [polypeptide binding]; other site
434923004301	L11 interface [polypeptide binding]; other site
434923004302	putative EF-Tu interaction site [polypeptide binding]; other site
434923004303	putative EF-G interaction site [polypeptide binding]; other site
434923004304	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
434923004305	23S rRNA interface [nucleotide binding]; other site
434923004306	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
434923004307	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
434923004308	mRNA/rRNA interface [nucleotide binding]; other site
434923004309	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
434923004310	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
434923004311	23S rRNA interface [nucleotide binding]; other site
434923004312	L7/L12 interface [polypeptide binding]; other site
434923004313	putative thiostrepton binding site; other site
434923004314	L25 interface [polypeptide binding]; other site
434923004315	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
434923004316	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
434923004317	putative homodimer interface [polypeptide binding]; other site
434923004318	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
434923004319	heterodimer interface [polypeptide binding]; other site
434923004320	homodimer interface [polypeptide binding]; other site
434923004321	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
434923004322	elongation factor Tu; Reviewed; Region: PRK00049
434923004323	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
434923004324	G1 box; other site
434923004325	GEF interaction site [polypeptide binding]; other site
434923004326	GTP/Mg2+ binding site [chemical binding]; other site
434923004327	Switch I region; other site
434923004328	G2 box; other site
434923004329	G3 box; other site
434923004330	Switch II region; other site
434923004331	G4 box; other site
434923004332	G5 box; other site
434923004333	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
434923004334	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
434923004335	Antibiotic Binding Site [chemical binding]; other site
434923004336	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
434923004337	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
434923004338	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
434923004339	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
434923004340	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
434923004341	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
434923004342	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
434923004343	NlpC/P60 family; Region: NLPC_P60; cl17555
434923004344	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
434923004345	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
434923004346	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
434923004347	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
434923004348	EamA-like transporter family; Region: EamA; pfam00892
434923004349	EamA-like transporter family; Region: EamA; pfam00892
434923004350	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
434923004351	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
434923004352	active site
434923004353	HIGH motif; other site
434923004354	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
434923004355	active site
434923004356	KMSKS motif; other site
434923004357	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
434923004358	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
434923004359	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
434923004360	active site
434923004361	catalytic residues [active]
434923004362	pantothenate kinase; Provisional; Region: PRK05439
434923004363	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
434923004364	ATP-binding site [chemical binding]; other site
434923004365	CoA-binding site [chemical binding]; other site
434923004366	Mg2+-binding site [ion binding]; other site
434923004367	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
434923004368	Surface antigen; Region: Bac_surface_Ag; pfam01103
434923004369	Family of unknown function (DUF490); Region: DUF490; pfam04357
434923004370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004371	muropeptide transporter; Reviewed; Region: ampG; PRK11902
434923004372	putative substrate translocation pore; other site
434923004373	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
434923004374	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
434923004375	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
434923004376	LAGLIDADG endonuclease; Region: LAGLIDADG_1; pfam00961
434923004377	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
434923004378	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
434923004379	active site
434923004380	HIGH motif; other site
434923004381	dimer interface [polypeptide binding]; other site
434923004382	KMSKS motif; other site
434923004383	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
434923004384	RNA binding surface [nucleotide binding]; other site
434923004385	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
434923004386	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
434923004387	Peptidase family M23; Region: Peptidase_M23; pfam01551
434923004388	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
434923004389	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
434923004390	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
434923004391	Walker A/P-loop; other site
434923004392	ATP binding site [chemical binding]; other site
434923004393	Q-loop/lid; other site
434923004394	ABC transporter signature motif; other site
434923004395	Walker B; other site
434923004396	D-loop; other site
434923004397	H-loop/switch region; other site
434923004398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
434923004399	dimer interface [polypeptide binding]; other site
434923004400	conserved gate region; other site
434923004401	ABC-ATPase subunit interface; other site
434923004402	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
434923004403	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
434923004404	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
434923004405	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
434923004406	active site
434923004407	ATP binding site [chemical binding]; other site
434923004408	substrate binding site [chemical binding]; other site
434923004409	acyl carrier protein; Validated; Region: PRK07117
434923004410	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
434923004411	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
434923004412	substrate binding site [chemical binding]; other site
434923004413	oxyanion hole (OAH) forming residues; other site
434923004414	trimer interface [polypeptide binding]; other site
434923004415	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
434923004416	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
434923004417	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
434923004418	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
434923004419	active site
434923004420	catalytic tetrad [active]
434923004421	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
434923004422	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
434923004423	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09677
434923004424	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674
434923004425	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
434923004426	putative major pilin subunit; Provisional; Region: PRK10574
434923004427	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
434923004428	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
434923004429	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923004430	Walker A motif; other site
434923004431	ATP binding site [chemical binding]; other site
434923004432	Walker B motif; other site
434923004433	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
434923004434	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
434923004435	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
434923004436	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
434923004437	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
434923004438	CoA-binding site [chemical binding]; other site
434923004439	ATP-binding [chemical binding]; other site
434923004440	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
434923004441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
434923004442	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
434923004443	hypothetical protein; Provisional; Region: PRK05287
434923004444	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923004445	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
434923004446	active site
434923004447	8-oxo-dGMP binding site [chemical binding]; other site
434923004448	nudix motif; other site
434923004449	metal binding site [ion binding]; metal-binding site
434923004450	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
434923004451	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
434923004452	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
434923004453	nucleotide binding region [chemical binding]; other site
434923004454	SEC-C motif; Region: SEC-C; pfam02810
434923004455	Protein of unknown function (DUF721); Region: DUF721; pfam05258
434923004456	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
434923004457	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
434923004458	cell division protein FtsZ; Validated; Region: PRK09330
434923004459	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
434923004460	nucleotide binding site [chemical binding]; other site
434923004461	SulA interaction site; other site
434923004462	cell division protein FtsA; Region: ftsA; TIGR01174
434923004463	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
434923004464	nucleotide binding site [chemical binding]; other site
434923004465	Cell division protein FtsA; Region: FtsA; pfam14450
434923004466	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
434923004467	active site clefts [active]
434923004468	zinc binding site [ion binding]; other site
434923004469	dimer interface [polypeptide binding]; other site
434923004470	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
434923004471	Cell division protein FtsQ; Region: FtsQ; pfam03799
434923004472	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
434923004473	FAD binding domain; Region: FAD_binding_4; pfam01565
434923004474	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
434923004475	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
434923004476	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
434923004477	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
434923004478	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
434923004479	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
434923004480	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
434923004481	active site
434923004482	homodimer interface [polypeptide binding]; other site
434923004483	cell division protein FtsW; Region: ftsW; TIGR02614
434923004484	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
434923004485	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
434923004486	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
434923004487	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
434923004488	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
434923004489	Mg++ binding site [ion binding]; other site
434923004490	putative catalytic motif [active]
434923004491	putative substrate binding site [chemical binding]; other site
434923004492	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
434923004493	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
434923004494	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
434923004495	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
434923004496	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
434923004497	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
434923004498	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
434923004499	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
434923004500	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
434923004501	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
434923004502	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
434923004503	Cell division protein FtsL; Region: FtsL; pfam04999
434923004504	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
434923004505	MraW methylase family; Region: Methyltransf_5; cl17771
434923004506	cell division protein MraZ; Reviewed; Region: PRK00326
434923004507	MraZ protein; Region: MraZ; pfam02381
434923004508	MraZ protein; Region: MraZ; pfam02381
434923004509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
434923004510	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
434923004511	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
434923004512	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
434923004513	NAD(P) binding site [chemical binding]; other site
434923004514	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
434923004515	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
434923004516	substrate-cofactor binding pocket; other site
434923004517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923004518	catalytic residue [active]
434923004519	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
434923004520	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
434923004521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
434923004522	ABC-ATPase subunit interface; other site
434923004523	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
434923004524	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
434923004525	Walker A/P-loop; other site
434923004526	ATP binding site [chemical binding]; other site
434923004527	Q-loop/lid; other site
434923004528	ABC transporter signature motif; other site
434923004529	Walker B; other site
434923004530	D-loop; other site
434923004531	H-loop/switch region; other site
434923004532	NIL domain; Region: NIL; pfam09383
434923004533	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
434923004534	hypothetical protein; Provisional; Region: PRK08201
434923004535	metal binding site [ion binding]; metal-binding site
434923004536	putative dimer interface [polypeptide binding]; other site
434923004537	L-aspartate oxidase; Provisional; Region: PRK09077
434923004538	L-aspartate oxidase; Provisional; Region: PRK06175
434923004539	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
434923004540	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
434923004541	catalytic core [active]
434923004542	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
434923004543	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
434923004544	dimerization interface [polypeptide binding]; other site
434923004545	active site
434923004546	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
434923004547	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
434923004548	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
434923004549	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
434923004550	PLD-like domain; Region: PLDc_2; pfam13091
434923004551	putative active site [active]
434923004552	catalytic site [active]
434923004553	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
434923004554	PLD-like domain; Region: PLDc_2; pfam13091
434923004555	putative active site [active]
434923004556	catalytic site [active]
434923004557	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
434923004558	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
434923004559	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
434923004560	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
434923004561	Clp amino terminal domain; Region: Clp_N; pfam02861
434923004562	Clp amino terminal domain; Region: Clp_N; pfam02861
434923004563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923004564	Walker A motif; other site
434923004565	ATP binding site [chemical binding]; other site
434923004566	Walker B motif; other site
434923004567	arginine finger; other site
434923004568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923004569	Walker A motif; other site
434923004570	ATP binding site [chemical binding]; other site
434923004571	Walker B motif; other site
434923004572	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
434923004573	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
434923004574	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
434923004575	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
434923004576	Tetratricopeptide repeat; Region: TPR_6; pfam13174
434923004577	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
434923004578	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
434923004579	ligand binding site [chemical binding]; other site
434923004580	translocation protein TolB; Provisional; Region: tolB; PRK04922
434923004581	TolB amino-terminal domain; Region: TolB_N; pfam04052
434923004582	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
434923004583	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
434923004584	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
434923004585	TolA protein; Region: tolA_full; TIGR02794
434923004586	TonB C terminal; Region: TonB_2; pfam13103
434923004587	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
434923004588	Sulfatase; Region: Sulfatase; pfam00884
434923004589	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
434923004590	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
434923004591	active site
434923004592	Predicted small secreted protein [Function unknown]; Region: COG5510
434923004593	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
434923004594	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
434923004595	Sulfatase; Region: Sulfatase; cl17466
434923004596	prolyl-tRNA synthetase; Provisional; Region: PRK09194
434923004597	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
434923004598	dimer interface [polypeptide binding]; other site
434923004599	motif 1; other site
434923004600	active site
434923004601	motif 2; other site
434923004602	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
434923004603	putative deacylase active site [active]
434923004604	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
434923004605	active site
434923004606	motif 3; other site
434923004607	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
434923004608	anticodon binding site; other site
434923004609	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
434923004610	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
434923004611	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
434923004612	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
434923004613	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
434923004614	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
434923004615	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
434923004616	active site
434923004617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923004618	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923004619	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923004620	TIGR02449 family protein; Region: TIGR02449
434923004621	Cell division protein ZapA; Region: ZapA; pfam05164
434923004622	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
434923004623	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
434923004624	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
434923004625	active site residue [active]
434923004626	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
434923004627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923004628	ATP binding site [chemical binding]; other site
434923004629	Mg2+ binding site [ion binding]; other site
434923004630	G-X-G motif; other site
434923004631	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
434923004632	anchoring element; other site
434923004633	dimer interface [polypeptide binding]; other site
434923004634	ATP binding site [chemical binding]; other site
434923004635	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
434923004636	active site
434923004637	metal binding site [ion binding]; metal-binding site
434923004638	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
434923004639	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
434923004640	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
434923004641	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
434923004642	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
434923004643	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
434923004644	Sporulation related domain; Region: SPOR; pfam05036
434923004645	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
434923004646	UbiA prenyltransferase family; Region: UbiA; pfam01040
434923004647	Chorismate lyase; Region: Chor_lyase; cl01230
434923004648	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
434923004649	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
434923004650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
434923004651	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
434923004652	HlyD family secretion protein; Region: HlyD_3; pfam13437
434923004653	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
434923004654	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
434923004655	Walker A/P-loop; other site
434923004656	ATP binding site [chemical binding]; other site
434923004657	Q-loop/lid; other site
434923004658	ABC transporter signature motif; other site
434923004659	Walker B; other site
434923004660	D-loop; other site
434923004661	H-loop/switch region; other site
434923004662	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
434923004663	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
434923004664	ligand binding site [chemical binding]; other site
434923004665	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
434923004666	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
434923004667	active site
434923004668	dimerization interface [polypeptide binding]; other site
434923004669	ferrochelatase; Reviewed; Region: hemH; PRK00035
434923004670	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
434923004671	C-terminal domain interface [polypeptide binding]; other site
434923004672	active site
434923004673	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
434923004674	active site
434923004675	N-terminal domain interface [polypeptide binding]; other site
434923004676	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
434923004677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923004678	S-adenosylmethionine binding site [chemical binding]; other site
434923004679	peptide chain release factor 1; Validated; Region: prfA; PRK00591
434923004680	This domain is found in peptide chain release factors; Region: PCRF; smart00937
434923004681	RF-1 domain; Region: RF-1; pfam00472
434923004682	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
434923004683	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
434923004684	tRNA; other site
434923004685	putative tRNA binding site [nucleotide binding]; other site
434923004686	putative NADP binding site [chemical binding]; other site
434923004687	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
434923004688	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
434923004689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004690	putative substrate translocation pore; other site
434923004691	Dihydroneopterin aldolase; Region: FolB; smart00905
434923004692	active site
434923004693	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
434923004694	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
434923004695	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
434923004696	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
434923004697	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
434923004698	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
434923004699	DNA binding residues [nucleotide binding]
434923004700	dimerization interface [polypeptide binding]; other site
434923004701	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
434923004702	Secretory lipase; Region: LIP; pfam03583
434923004703	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
434923004704	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
434923004705	Substrate binding site; other site
434923004706	metal-binding site
434923004707	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
434923004708	Phosphotransferase enzyme family; Region: APH; pfam01636
434923004709	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
434923004710	Organic solvent tolerance protein; Region: OstA_C; pfam04453
434923004711	SurA N-terminal domain; Region: SurA_N; pfam09312
434923004712	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
434923004713	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
434923004714	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
434923004715	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
434923004716	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
434923004717	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
434923004718	Ligand Binding Site [chemical binding]; other site
434923004719	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
434923004720	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
434923004721	tandem repeat interface [polypeptide binding]; other site
434923004722	oligomer interface [polypeptide binding]; other site
434923004723	active site residues [active]
434923004724	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
434923004725	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
434923004726	active site
434923004727	metal binding site [ion binding]; metal-binding site
434923004728	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
434923004729	Transposase; Region: DEDD_Tnp_IS110; pfam01548
434923004730	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
434923004731	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
434923004732	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
434923004733	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
434923004734	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
434923004735	folate binding site [chemical binding]; other site
434923004736	NADP+ binding site [chemical binding]; other site
434923004737	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
434923004738	acylphosphatase; Provisional; Region: PRK14437
434923004739	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
434923004740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
434923004741	active site
434923004742	motif I; other site
434923004743	motif II; other site
434923004744	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
434923004745	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
434923004746	putative active site [active]
434923004747	substrate binding site [chemical binding]; other site
434923004748	putative cosubstrate binding site; other site
434923004749	catalytic site [active]
434923004750	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
434923004751	substrate binding site [chemical binding]; other site
434923004752	DNA protecting protein DprA; Region: dprA; TIGR00732
434923004753	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
434923004754	Protein of unknown function (DUF494); Region: DUF494; pfam04361
434923004755	DNA topoisomerase I; Validated; Region: PRK06599
434923004756	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
434923004757	active site
434923004758	interdomain interaction site; other site
434923004759	putative metal-binding site [ion binding]; other site
434923004760	nucleotide binding site [chemical binding]; other site
434923004761	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
434923004762	domain I; other site
434923004763	DNA binding groove [nucleotide binding]
434923004764	phosphate binding site [ion binding]; other site
434923004765	domain II; other site
434923004766	domain III; other site
434923004767	nucleotide binding site [chemical binding]; other site
434923004768	catalytic site [active]
434923004769	domain IV; other site
434923004770	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
434923004771	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
434923004772	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
434923004773	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
434923004774	AIR carboxylase; Region: AIRC; pfam00731
434923004775	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
434923004776	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
434923004777	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
434923004778	putative active site [active]
434923004779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
434923004780	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
434923004781	dimerization interface [polypeptide binding]; other site
434923004782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
434923004783	dimer interface [polypeptide binding]; other site
434923004784	phosphorylation site [posttranslational modification]
434923004785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
434923004786	ATP binding site [chemical binding]; other site
434923004787	Mg2+ binding site [ion binding]; other site
434923004788	G-X-G motif; other site
434923004789	osmolarity response regulator; Provisional; Region: ompR; PRK09468
434923004790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
434923004791	active site
434923004792	phosphorylation site [posttranslational modification]
434923004793	intermolecular recognition site; other site
434923004794	dimerization interface [polypeptide binding]; other site
434923004795	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
434923004796	DNA binding site [nucleotide binding]
434923004797	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
434923004798	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
434923004799	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
434923004800	active site
434923004801	HIGH motif; other site
434923004802	nucleotide binding site [chemical binding]; other site
434923004803	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
434923004804	KMSK motif region; other site
434923004805	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
434923004806	tRNA binding surface [nucleotide binding]; other site
434923004807	anticodon binding site; other site
434923004808	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
434923004809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
434923004810	GtrA-like protein; Region: GtrA; pfam04138
434923004811	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
434923004812	active site
434923004813	HslU subunit interaction site [polypeptide binding]; other site
434923004814	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
434923004815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
434923004816	Walker A motif; other site
434923004817	ATP binding site [chemical binding]; other site
434923004818	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
434923004819	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
434923004820	Predicted membrane protein [Function unknown]; Region: COG2323
434923004821	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
434923004822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004823	POT family; Region: PTR2; cl17359
434923004824	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
434923004825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
434923004826	S-adenosylmethionine binding site [chemical binding]; other site
434923004827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
434923004828	SCP-2 sterol transfer family; Region: SCP2; pfam02036
434923004829	ABC1 family; Region: ABC1; cl17513
434923004830	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
434923004831	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
434923004832	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
434923004833	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
434923004834	Membrane fusogenic activity; Region: BMFP; pfam04380
434923004835	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
434923004836	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
434923004837	dimer interface [polypeptide binding]; other site
434923004838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923004839	catalytic residue [active]
434923004840	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
434923004841	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
434923004842	homodimer interface [polypeptide binding]; other site
434923004843	substrate-cofactor binding pocket; other site
434923004844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
434923004845	catalytic residue [active]
434923004846	S-adenosylmethionine synthetase; Validated; Region: PRK05250
434923004847	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
434923004848	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
434923004849	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
434923004850	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
434923004851	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
434923004852	homotetramer interface [polypeptide binding]; other site
434923004853	ligand binding site [chemical binding]; other site
434923004854	catalytic site [active]
434923004855	NAD binding site [chemical binding]; other site
434923004856	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
434923004857	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
434923004858	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
434923004859	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
434923004860	metal binding site [ion binding]; metal-binding site
434923004861	active site
434923004862	I-site; other site
434923004863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
434923004864	PAS domain; Region: PAS_9; pfam13426
434923004865	putative active site [active]
434923004866	heme pocket [chemical binding]; other site
434923004867	PAS domain; Region: PAS_9; pfam13426
434923004868	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
434923004869	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
434923004870	metal binding site [ion binding]; metal-binding site
434923004871	active site
434923004872	I-site; other site
434923004873	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
434923004874	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
434923004875	FAD binding site [chemical binding]; other site
434923004876	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
434923004877	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
434923004878	THF binding site; other site
434923004879	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
434923004880	substrate binding site [chemical binding]; other site
434923004881	THF binding site; other site
434923004882	zinc-binding site [ion binding]; other site
434923004883	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
434923004884	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
434923004885	active site
434923004886	HIGH motif; other site
434923004887	dimer interface [polypeptide binding]; other site
434923004888	KMSKS motif; other site
434923004889	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
434923004890	Part of AAA domain; Region: AAA_19; pfam13245
434923004891	Family description; Region: UvrD_C_2; pfam13538
434923004892	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
434923004893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004894	metabolite-proton symporter; Region: 2A0106; TIGR00883
434923004895	putative substrate translocation pore; other site
434923004896	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
434923004897	N-acetyl-D-glucosamine binding site [chemical binding]; other site
434923004898	catalytic residue [active]
434923004899	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
434923004900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004901	putative substrate translocation pore; other site
434923004902	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
434923004903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
434923004904	putative substrate translocation pore; other site
434923004905	thymidine kinase; Provisional; Region: PRK04296
434923004906	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
434923004907	ATP binding site [chemical binding]; other site
434923004908	Walker A motif; other site
434923004909	Walker B motif; other site
434923004910	Chorismate mutase type II; Region: CM_2; smart00830
434923004911	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
434923004912	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
434923004913	putative acyl-acceptor binding pocket; other site
434923004914	porphobilinogen deaminase; Region: hemC; TIGR00212
434923004915	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
434923004916	domain interfaces; other site
434923004917	active site
434923004918	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
434923004919	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
434923004920	active site
434923004921	catalytic residue [active]
434923004922	dimer interface [polypeptide binding]; other site
434923004923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
434923004924	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
434923004925	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
434923004926	active site
434923004927	Fic family protein [Function unknown]; Region: COG3177
434923004928	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
434923004929	Fic/DOC family; Region: Fic; pfam02661
434923004930	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
434923004931	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
434923004932	HemY protein N-terminus; Region: HemY_N; pfam07219
434923004933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
434923004934	binding surface
434923004935	TPR motif; other site
434923004936	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
434923004937	Predicted periplasmic protein [Function unknown]; Region: COG3698
434923004938	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
434923004939	Ligand Binding Site [chemical binding]; other site
434923004940	similar to hypothetical protein
434923004941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
434923004942	transcription termination factor Rho; Provisional; Region: rho; PRK09376
434923004943	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
434923004944	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
434923004945	RNA binding site [nucleotide binding]; other site
434923004946	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
434923004947	multimer interface [polypeptide binding]; other site
434923004948	Walker A motif; other site
434923004949	ATP binding site [chemical binding]; other site
434923004950	Walker B motif; other site
434923004951	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
434923004952	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
434923004953	catalytic residues [active]
434923004954	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
434923004955	Na2 binding site [ion binding]; other site
434923004956	putative substrate binding site 1 [chemical binding]; other site
434923004957	Na binding site 1 [ion binding]; other site
434923004958	putative substrate binding site 2 [chemical binding]; other site
434923004959	YGGT family; Region: YGGT; pfam02325
434923004960	YGGT family; Region: YGGT; pfam02325
434923004961	pyrroline-5-carboxylate reductase; Region: PLN02688
434923004962	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
434923004963	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
434923004964	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
434923004965	catalytic residue [active]
434923004966	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
434923004967	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
434923004968	active site
434923004969	substrate-binding site [chemical binding]; other site
434923004970	metal-binding site [ion binding]
434923004971	ATP binding site [chemical binding]; other site
434923004972	hypothetical protein; Validated; Region: PRK00228
434923004973	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
434923004974	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK13814
434923004975	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
434923004976	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185