-- dump date   	20140619_053349
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
360115000001	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
360115000002	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
360115000003	Int/Topo IB signature motif; other site
360115000004	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
360115000005	Coxiella burnetii protein of unknown function (DUF807); Region: DUF807; pfam05660
360115000006	Coxiella burnetii protein of unknown function (DUF762); Region: DUF762; pfam05555
360115000007	Uncharacterized conserved protein [Function unknown]; Region: COG2433
360115000008	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
360115000009	Coxiella burnetii protein of unknown function (DUF762); Region: DUF762; pfam05555
360115000010	Coxiella burnetii protein of unknown function (DUF807); Region: DUF807; pfam05660
360115000011	Predicted transcriptional regulator [Transcription]; Region: COG2944
360115000012	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115000013	non-specific DNA binding site [nucleotide binding]; other site
360115000014	salt bridge; other site
360115000015	sequence-specific DNA binding site [nucleotide binding]; other site
360115000016	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
360115000017	AAA domain; Region: AAA_30; pfam13604
360115000018	Family description; Region: UvrD_C_2; pfam13538
360115000019	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
360115000020	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
360115000021	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
360115000022	trimer interface [polypeptide binding]; other site
360115000023	putative metal binding site [ion binding]; other site
360115000024	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
360115000025	ParB-like nuclease domain; Region: ParBc; pfam02195
360115000026	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
360115000027	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
360115000028	P-loop; other site
360115000029	Magnesium ion binding site [ion binding]; other site
360115000030	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
360115000031	Magnesium ion binding site [ion binding]; other site
360115000032	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
360115000033	ParB-like nuclease domain; Region: ParBc; pfam02195
360115000034	Initiator Replication protein; Region: Rep_3; pfam01051
360115000035	mobile mystery protein A; Region: mob_myst_A; TIGR02612
360115000036	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115000037	non-specific DNA binding site [nucleotide binding]; other site
360115000038	salt bridge; other site
360115000039	sequence-specific DNA binding site [nucleotide binding]; other site
360115000040	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
360115000041	DNA binding site [nucleotide binding]
360115000042	dimer interface [polypeptide binding]; other site
360115000043	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
360115000044	NlpC/P60 family; Region: NLPC_P60; cl17555
360115000045	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
360115000046	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
360115000047	DnaA N-terminal domain; Region: DnaA_N; pfam11638
360115000048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115000049	Walker A motif; other site
360115000050	ATP binding site [chemical binding]; other site
360115000051	Walker B motif; other site
360115000052	arginine finger; other site
360115000053	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
360115000054	DnaA box-binding interface [nucleotide binding]; other site
360115000055	DNA polymerase III subunit beta; Validated; Region: PRK05643
360115000056	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
360115000057	putative DNA binding surface [nucleotide binding]; other site
360115000058	dimer interface [polypeptide binding]; other site
360115000059	beta-clamp/clamp loader binding surface; other site
360115000060	beta-clamp/translesion DNA polymerase binding surface; other site
360115000061	recombination protein F; Reviewed; Region: recF; PRK00064
360115000062	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115000063	Walker A/P-loop; other site
360115000064	ATP binding site [chemical binding]; other site
360115000065	Q-loop/lid; other site
360115000066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115000067	ABC transporter signature motif; other site
360115000068	Walker B; other site
360115000069	D-loop; other site
360115000070	H-loop/switch region; other site
360115000071	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
360115000072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115000073	ATP binding site [chemical binding]; other site
360115000074	Mg2+ binding site [ion binding]; other site
360115000075	G-X-G motif; other site
360115000076	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
360115000077	anchoring element; other site
360115000078	dimer interface [polypeptide binding]; other site
360115000079	ATP binding site [chemical binding]; other site
360115000080	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
360115000081	active site
360115000082	putative metal-binding site [ion binding]; other site
360115000083	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
360115000084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115000085	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115000086	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115000087	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
360115000088	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
360115000089	active site
360115000090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
360115000091	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
360115000092	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
360115000093	active site
360115000094	catalytic residue [active]
360115000095	dimer interface [polypeptide binding]; other site
360115000096	porphobilinogen deaminase; Region: hemC; TIGR00212
360115000097	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
360115000098	domain interfaces; other site
360115000099	active site
360115000100	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
360115000101	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
360115000102	putative acyl-acceptor binding pocket; other site
360115000103	Chorismate mutase type II; Region: CM_2; smart00830
360115000104	thymidine kinase; Provisional; Region: PRK04296
360115000105	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115000106	ATP binding site [chemical binding]; other site
360115000107	Walker A motif; other site
360115000108	Walker B motif; other site
360115000109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000110	putative substrate translocation pore; other site
360115000111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000112	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115000113	putative substrate translocation pore; other site
360115000114	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
360115000115	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
360115000116	N-acetyl-D-glucosamine binding site [chemical binding]; other site
360115000117	catalytic residue [active]
360115000118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000119	metabolite-proton symporter; Region: 2A0106; TIGR00883
360115000120	putative substrate translocation pore; other site
360115000121	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
360115000122	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
360115000123	Part of AAA domain; Region: AAA_19; pfam13245
360115000124	Family description; Region: UvrD_C_2; pfam13538
360115000125	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
360115000126	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
360115000127	active site
360115000128	HIGH motif; other site
360115000129	dimer interface [polypeptide binding]; other site
360115000130	KMSKS motif; other site
360115000131	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
360115000132	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
360115000133	THF binding site; other site
360115000134	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
360115000135	substrate binding site [chemical binding]; other site
360115000136	THF binding site; other site
360115000137	zinc-binding site [ion binding]; other site
360115000138	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
360115000139	FAD binding site [chemical binding]; other site
360115000140	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
360115000141	active site
360115000142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
360115000143	PAS domain; Region: PAS_9; pfam13426
360115000144	putative active site [active]
360115000145	heme pocket [chemical binding]; other site
360115000146	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
360115000147	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
360115000148	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
360115000149	HlyD family secretion protein; Region: HlyD_3; pfam13437
360115000150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115000151	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
360115000152	Walker A/P-loop; other site
360115000153	ATP binding site [chemical binding]; other site
360115000154	Q-loop/lid; other site
360115000155	ABC transporter signature motif; other site
360115000156	Walker B; other site
360115000157	D-loop; other site
360115000158	H-loop/switch region; other site
360115000159	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
360115000160	flagellin modification protein A; Provisional; Region: PRK09186
360115000161	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
360115000162	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
360115000163	homotetramer interface [polypeptide binding]; other site
360115000164	ligand binding site [chemical binding]; other site
360115000165	catalytic site [active]
360115000166	NAD binding site [chemical binding]; other site
360115000167	S-adenosylmethionine synthetase; Validated; Region: PRK05250
360115000168	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
360115000169	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
360115000170	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
360115000171	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
360115000172	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
360115000173	homodimer interface [polypeptide binding]; other site
360115000174	substrate-cofactor binding pocket; other site
360115000175	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115000176	catalytic residue [active]
360115000177	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
360115000178	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
360115000179	dimer interface [polypeptide binding]; other site
360115000180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115000181	catalytic residue [active]
360115000182	Membrane fusogenic activity; Region: BMFP; pfam04380
360115000183	AAA domain; Region: AAA_14; pfam13173
360115000184	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
360115000185	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
360115000186	ABC1 family; Region: ABC1; cl17513
360115000187	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
360115000188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
360115000189	SCP-2 sterol transfer family; Region: SCP2; pfam02036
360115000190	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
360115000191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115000192	S-adenosylmethionine binding site [chemical binding]; other site
360115000193	Predicted membrane protein [Function unknown]; Region: COG2323
360115000194	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
360115000195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115000196	Walker A motif; other site
360115000197	ATP binding site [chemical binding]; other site
360115000198	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
360115000199	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
360115000200	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
360115000201	active site
360115000202	HslU subunit interaction site [polypeptide binding]; other site
360115000203	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
360115000204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
360115000205	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
360115000206	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
360115000207	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
360115000208	active site
360115000209	HIGH motif; other site
360115000210	nucleotide binding site [chemical binding]; other site
360115000211	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
360115000212	KMSK motif region; other site
360115000213	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
360115000214	tRNA binding surface [nucleotide binding]; other site
360115000215	anticodon binding site; other site
360115000216	osmolarity response regulator; Provisional; Region: ompR; PRK09468
360115000217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115000218	active site
360115000219	phosphorylation site [posttranslational modification]
360115000220	intermolecular recognition site; other site
360115000221	dimerization interface [polypeptide binding]; other site
360115000222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
360115000223	DNA binding site [nucleotide binding]
360115000224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
360115000225	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
360115000226	dimerization interface [polypeptide binding]; other site
360115000227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115000228	dimer interface [polypeptide binding]; other site
360115000229	phosphorylation site [posttranslational modification]
360115000230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115000231	ATP binding site [chemical binding]; other site
360115000232	Mg2+ binding site [ion binding]; other site
360115000233	G-X-G motif; other site
360115000234	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
360115000235	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
360115000236	putative active site [active]
360115000237	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
360115000238	AIR carboxylase; Region: AIRC; pfam00731
360115000239	DNA topoisomerase I; Validated; Region: PRK06599
360115000240	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
360115000241	active site
360115000242	interdomain interaction site; other site
360115000243	putative metal-binding site [ion binding]; other site
360115000244	nucleotide binding site [chemical binding]; other site
360115000245	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
360115000246	domain I; other site
360115000247	DNA binding groove [nucleotide binding]
360115000248	phosphate binding site [ion binding]; other site
360115000249	domain II; other site
360115000250	domain III; other site
360115000251	nucleotide binding site [chemical binding]; other site
360115000252	catalytic site [active]
360115000253	domain IV; other site
360115000254	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
360115000255	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
360115000256	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
360115000257	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
360115000258	Protein of unknown function (DUF494); Region: DUF494; pfam04361
360115000259	DNA protecting protein DprA; Region: dprA; TIGR00732
360115000260	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
360115000261	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
360115000262	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
360115000263	putative active site [active]
360115000264	substrate binding site [chemical binding]; other site
360115000265	putative cosubstrate binding site; other site
360115000266	catalytic site [active]
360115000267	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
360115000268	substrate binding site [chemical binding]; other site
360115000269	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
360115000270	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115000271	active site
360115000272	motif I; other site
360115000273	motif II; other site
360115000274	acylphosphatase; Provisional; Region: PRK14437
360115000275	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
360115000276	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
360115000277	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
360115000278	folate binding site [chemical binding]; other site
360115000279	NADP+ binding site [chemical binding]; other site
360115000280	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
360115000281	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
360115000282	active site
360115000283	metal binding site [ion binding]; metal-binding site
360115000284	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
360115000285	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
360115000286	tandem repeat interface [polypeptide binding]; other site
360115000287	oligomer interface [polypeptide binding]; other site
360115000288	active site residues [active]
360115000289	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
360115000290	Ligand Binding Site [chemical binding]; other site
360115000291	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
360115000292	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
360115000293	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
360115000294	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
360115000295	SurA N-terminal domain; Region: SurA_N; pfam09312
360115000296	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
360115000297	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
360115000298	Organic solvent tolerance protein; Region: OstA_C; pfam04453
360115000299	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
360115000300	Phosphotransferase enzyme family; Region: APH; pfam01636
360115000301	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
360115000302	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
360115000303	Substrate binding site; other site
360115000304	metal-binding site
360115000305	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
360115000306	putative hydrolase; Provisional; Region: PRK11460
360115000307	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
360115000308	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
360115000309	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
360115000310	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
360115000311	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
360115000312	Dihydroneopterin aldolase; Region: FolB; smart00905
360115000313	active site
360115000314	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
360115000315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000316	putative substrate translocation pore; other site
360115000317	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
360115000318	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
360115000319	tRNA; other site
360115000320	putative tRNA binding site [nucleotide binding]; other site
360115000321	putative NADP binding site [chemical binding]; other site
360115000322	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
360115000323	peptide chain release factor 1; Validated; Region: prfA; PRK00591
360115000324	This domain is found in peptide chain release factors; Region: PCRF; smart00937
360115000325	RF-1 domain; Region: RF-1; pfam00472
360115000326	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
360115000327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115000328	S-adenosylmethionine binding site [chemical binding]; other site
360115000329	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115000330	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115000331	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115000332	TIGR02449 family protein; Region: TIGR02449
360115000333	Cell division protein ZapA; Region: ZapA; pfam05164
360115000334	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
360115000335	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
360115000336	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
360115000337	active site residue [active]
360115000338	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
360115000339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115000340	ATP binding site [chemical binding]; other site
360115000341	Mg2+ binding site [ion binding]; other site
360115000342	G-X-G motif; other site
360115000343	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
360115000344	anchoring element; other site
360115000345	dimer interface [polypeptide binding]; other site
360115000346	ATP binding site [chemical binding]; other site
360115000347	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
360115000348	active site
360115000349	metal binding site [ion binding]; metal-binding site
360115000350	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
360115000351	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
360115000352	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
360115000353	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
360115000354	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
360115000355	HSP70 interaction site [polypeptide binding]; other site
360115000356	Protein of unknown function (DUF1658); Region: DUF1658; pfam07871
360115000357	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
360115000358	Sporulation related domain; Region: SPOR; pfam05036
360115000359	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
360115000360	UbiA prenyltransferase family; Region: UbiA; pfam01040
360115000361	Chorismate lyase; Region: Chor_lyase; cl01230
360115000362	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115000363	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
360115000364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
360115000365	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
360115000366	HlyD family secretion protein; Region: HlyD_3; pfam13437
360115000367	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
360115000368	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
360115000369	Walker A/P-loop; other site
360115000370	ATP binding site [chemical binding]; other site
360115000371	Q-loop/lid; other site
360115000372	ABC transporter signature motif; other site
360115000373	Walker B; other site
360115000374	D-loop; other site
360115000375	H-loop/switch region; other site
360115000376	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
360115000377	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
360115000378	ligand binding site [chemical binding]; other site
360115000379	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
360115000380	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
360115000381	active site
360115000382	dimerization interface [polypeptide binding]; other site
360115000383	ferrochelatase; Reviewed; Region: hemH; PRK00035
360115000384	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
360115000385	C-terminal domain interface [polypeptide binding]; other site
360115000386	active site
360115000387	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
360115000388	active site
360115000389	N-terminal domain interface [polypeptide binding]; other site
360115000390	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115000391	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115000392	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115000393	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
360115000394	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115000395	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115000396	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115000397	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115000398	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
360115000399	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
360115000400	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
360115000401	active site
360115000402	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
360115000403	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
360115000404	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
360115000405	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
360115000406	prolyl-tRNA synthetase; Provisional; Region: PRK09194
360115000407	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
360115000408	dimer interface [polypeptide binding]; other site
360115000409	motif 1; other site
360115000410	active site
360115000411	motif 2; other site
360115000412	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
360115000413	putative deacylase active site [active]
360115000414	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
360115000415	active site
360115000416	motif 3; other site
360115000417	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
360115000418	anticodon binding site; other site
360115000419	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
360115000420	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
360115000421	Sulfatase; Region: Sulfatase; cl17466
360115000422	Predicted small secreted protein [Function unknown]; Region: COG5510
360115000423	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
360115000424	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
360115000425	active site
360115000426	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
360115000427	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
360115000428	Sulfatase; Region: Sulfatase; pfam00884
360115000429	TolA protein; Region: tolA_full; TIGR02794
360115000430	TonB C terminal; Region: TonB_2; pfam13103
360115000431	translocation protein TolB; Provisional; Region: tolB; PRK04922
360115000432	TolB amino-terminal domain; Region: TolB_N; pfam04052
360115000433	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
360115000434	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
360115000435	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
360115000436	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
360115000437	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
360115000438	ligand binding site [chemical binding]; other site
360115000439	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
360115000440	Tetratricopeptide repeat; Region: TPR_6; pfam13174
360115000441	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
360115000442	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
360115000443	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
360115000444	Clp amino terminal domain; Region: Clp_N; pfam02861
360115000445	Clp amino terminal domain; Region: Clp_N; pfam02861
360115000446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115000447	Walker A motif; other site
360115000448	ATP binding site [chemical binding]; other site
360115000449	Walker B motif; other site
360115000450	arginine finger; other site
360115000451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115000452	Walker A motif; other site
360115000453	ATP binding site [chemical binding]; other site
360115000454	Walker B motif; other site
360115000455	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
360115000456	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
360115000457	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
360115000458	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
360115000459	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
360115000460	PLD-like domain; Region: PLDc_2; pfam13091
360115000461	putative active site [active]
360115000462	catalytic site [active]
360115000463	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
360115000464	PLD-like domain; Region: PLDc_2; pfam13091
360115000465	putative active site [active]
360115000466	catalytic site [active]
360115000467	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
360115000468	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
360115000469	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
360115000470	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
360115000471	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
360115000472	dimerization interface [polypeptide binding]; other site
360115000473	active site
360115000474	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
360115000475	catalytic core [active]
360115000476	L-aspartate oxidase; Provisional; Region: PRK09077
360115000477	L-aspartate oxidase; Provisional; Region: PRK06175
360115000478	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
360115000479	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
360115000480	hypothetical protein; Provisional; Region: PRK08201
360115000481	metal binding site [ion binding]; metal-binding site
360115000482	putative dimer interface [polypeptide binding]; other site
360115000483	Repeats found in Drosophila proteins; Region: DM9; smart00696
360115000484	Protein of unknown function (DUF3421); Region: DUF3421; pfam11901
360115000485	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
360115000486	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
360115000487	Walker A/P-loop; other site
360115000488	ATP binding site [chemical binding]; other site
360115000489	Q-loop/lid; other site
360115000490	ABC transporter signature motif; other site
360115000491	Walker B; other site
360115000492	D-loop; other site
360115000493	H-loop/switch region; other site
360115000494	NIL domain; Region: NIL; pfam09383
360115000495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115000496	ABC-ATPase subunit interface; other site
360115000497	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
360115000498	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
360115000499	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
360115000500	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
360115000501	substrate-cofactor binding pocket; other site
360115000502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115000503	catalytic residue [active]
360115000504	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
360115000505	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
360115000506	NAD(P) binding site [chemical binding]; other site
360115000507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
360115000508	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
360115000509	cell division protein MraZ; Reviewed; Region: PRK00326
360115000510	MraZ protein; Region: MraZ; pfam02381
360115000511	MraZ protein; Region: MraZ; pfam02381
360115000512	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
360115000513	MraW methylase family; Region: Methyltransf_5; cl17771
360115000514	Cell division protein FtsL; Region: FtsL; pfam04999
360115000515	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
360115000516	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
360115000517	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
360115000518	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
360115000519	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
360115000520	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
360115000521	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
360115000522	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
360115000523	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
360115000524	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
360115000525	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
360115000526	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
360115000527	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
360115000528	Mg++ binding site [ion binding]; other site
360115000529	putative catalytic motif [active]
360115000530	putative substrate binding site [chemical binding]; other site
360115000531	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
360115000532	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
360115000533	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
360115000534	cell division protein FtsW; Region: ftsW; TIGR02614
360115000535	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
360115000536	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
360115000537	active site
360115000538	homodimer interface [polypeptide binding]; other site
360115000539	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
360115000540	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
360115000541	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
360115000542	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
360115000543	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
360115000544	FAD binding domain; Region: FAD_binding_4; pfam01565
360115000545	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
360115000546	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
360115000547	Cell division protein FtsQ; Region: FtsQ; pfam03799
360115000548	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
360115000549	active site clefts [active]
360115000550	zinc binding site [ion binding]; other site
360115000551	dimer interface [polypeptide binding]; other site
360115000552	cell division protein FtsA; Region: ftsA; TIGR01174
360115000553	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
360115000554	nucleotide binding site [chemical binding]; other site
360115000555	Cell division protein FtsA; Region: FtsA; pfam14450
360115000556	cell division protein FtsZ; Validated; Region: PRK09330
360115000557	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
360115000558	nucleotide binding site [chemical binding]; other site
360115000559	SulA interaction site; other site
360115000560	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
360115000561	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
360115000562	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115000563	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115000564	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115000565	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115000566	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115000567	Protein of unknown function (DUF721); Region: DUF721; pfam05258
360115000568	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
360115000569	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
360115000570	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
360115000571	nucleotide binding region [chemical binding]; other site
360115000572	SEC-C motif; Region: SEC-C; pfam02810
360115000573	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
360115000574	active site
360115000575	8-oxo-dGMP binding site [chemical binding]; other site
360115000576	nudix motif; other site
360115000577	metal binding site [ion binding]; metal-binding site
360115000578	hypothetical protein; Provisional; Region: PRK05287
360115000579	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
360115000580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
360115000581	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
360115000582	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
360115000583	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
360115000584	CoA-binding site [chemical binding]; other site
360115000585	ATP-binding [chemical binding]; other site
360115000586	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
360115000587	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
360115000588	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
360115000589	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
360115000590	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
360115000591	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
360115000592	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
360115000593	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
360115000594	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115000595	Walker A motif; other site
360115000596	ATP binding site [chemical binding]; other site
360115000597	Walker B motif; other site
360115000598	putative major pilin subunit; Provisional; Region: PRK10574
360115000599	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
360115000600	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674
360115000601	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09677
360115000602	acyl carrier protein; Validated; Region: PRK07117
360115000603	Condensation domain; Region: Condensation; pfam00668
360115000604	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
360115000605	active site
360115000606	ATP binding site [chemical binding]; other site
360115000607	substrate binding site [chemical binding]; other site
360115000608	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
360115000609	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
360115000610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115000611	dimer interface [polypeptide binding]; other site
360115000612	conserved gate region; other site
360115000613	ABC-ATPase subunit interface; other site
360115000614	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
360115000615	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
360115000616	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
360115000617	Walker A/P-loop; other site
360115000618	ATP binding site [chemical binding]; other site
360115000619	Q-loop/lid; other site
360115000620	ABC transporter signature motif; other site
360115000621	Walker B; other site
360115000622	D-loop; other site
360115000623	H-loop/switch region; other site
360115000624	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
360115000625	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
360115000626	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
360115000627	Peptidase family M23; Region: Peptidase_M23; pfam01551
360115000628	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
360115000629	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
360115000630	active site
360115000631	HIGH motif; other site
360115000632	dimer interface [polypeptide binding]; other site
360115000633	KMSKS motif; other site
360115000634	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
360115000635	RNA binding surface [nucleotide binding]; other site
360115000636	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
360115000637	four helix bundle protein; Region: TIGR02436
360115000638	LAGLIDADG endonuclease; Region: LAGLIDADG_1; pfam00961
360115000639	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
360115000640	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
360115000641	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
360115000642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000643	muropeptide transporter; Reviewed; Region: ampG; PRK11902
360115000644	putative substrate translocation pore; other site
360115000645	Family of unknown function (DUF490); Region: DUF490; pfam04357
360115000646	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
360115000647	Surface antigen; Region: Bac_surface_Ag; pfam01103
360115000648	pantothenate kinase; Provisional; Region: PRK05439
360115000649	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
360115000650	ATP-binding site [chemical binding]; other site
360115000651	CoA-binding site [chemical binding]; other site
360115000652	Mg2+-binding site [ion binding]; other site
360115000653	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
360115000654	active site
360115000655	catalytic residues [active]
360115000656	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115000657	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
360115000658	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
360115000659	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
360115000660	active site
360115000661	HIGH motif; other site
360115000662	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
360115000663	active site
360115000664	KMSKS motif; other site
360115000665	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
360115000666	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
360115000667	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
360115000668	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
360115000669	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
360115000670	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
360115000671	elongation factor Tu; Reviewed; Region: PRK00049
360115000672	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
360115000673	G1 box; other site
360115000674	GEF interaction site [polypeptide binding]; other site
360115000675	GTP/Mg2+ binding site [chemical binding]; other site
360115000676	Switch I region; other site
360115000677	G2 box; other site
360115000678	G3 box; other site
360115000679	Switch II region; other site
360115000680	G4 box; other site
360115000681	G5 box; other site
360115000682	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
360115000683	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
360115000684	Antibiotic Binding Site [chemical binding]; other site
360115000685	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
360115000686	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
360115000687	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
360115000688	putative homodimer interface [polypeptide binding]; other site
360115000689	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
360115000690	heterodimer interface [polypeptide binding]; other site
360115000691	homodimer interface [polypeptide binding]; other site
360115000692	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
360115000693	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
360115000694	23S rRNA interface [nucleotide binding]; other site
360115000695	L7/L12 interface [polypeptide binding]; other site
360115000696	putative thiostrepton binding site; other site
360115000697	L25 interface [polypeptide binding]; other site
360115000698	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
360115000699	mRNA/rRNA interface [nucleotide binding]; other site
360115000700	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
360115000701	23S rRNA interface [nucleotide binding]; other site
360115000702	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
360115000703	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
360115000704	core dimer interface [polypeptide binding]; other site
360115000705	peripheral dimer interface [polypeptide binding]; other site
360115000706	L10 interface [polypeptide binding]; other site
360115000707	L11 interface [polypeptide binding]; other site
360115000708	putative EF-Tu interaction site [polypeptide binding]; other site
360115000709	putative EF-G interaction site [polypeptide binding]; other site
360115000710	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
360115000711	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
360115000712	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
360115000713	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
360115000714	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
360115000715	RPB12 interaction site [polypeptide binding]; other site
360115000716	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
360115000717	RPB3 interaction site [polypeptide binding]; other site
360115000718	RPB1 interaction site [polypeptide binding]; other site
360115000719	RPB11 interaction site [polypeptide binding]; other site
360115000720	RPB10 interaction site [polypeptide binding]; other site
360115000721	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
360115000722	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
360115000723	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
360115000724	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
360115000725	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
360115000726	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
360115000727	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
360115000728	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
360115000729	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
360115000730	DNA binding site [nucleotide binding]
360115000731	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
360115000732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115000733	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115000734	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115000735	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
360115000736	S17 interaction site [polypeptide binding]; other site
360115000737	S8 interaction site; other site
360115000738	16S rRNA interaction site [nucleotide binding]; other site
360115000739	streptomycin interaction site [chemical binding]; other site
360115000740	23S rRNA interaction site [nucleotide binding]; other site
360115000741	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
360115000742	30S ribosomal protein S7; Validated; Region: PRK05302
360115000743	elongation factor G; Reviewed; Region: PRK00007
360115000744	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
360115000745	G1 box; other site
360115000746	putative GEF interaction site [polypeptide binding]; other site
360115000747	GTP/Mg2+ binding site [chemical binding]; other site
360115000748	Switch I region; other site
360115000749	G2 box; other site
360115000750	G3 box; other site
360115000751	Switch II region; other site
360115000752	G4 box; other site
360115000753	G5 box; other site
360115000754	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
360115000755	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
360115000756	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
360115000757	elongation factor Tu; Reviewed; Region: PRK00049
360115000758	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
360115000759	G1 box; other site
360115000760	GEF interaction site [polypeptide binding]; other site
360115000761	GTP/Mg2+ binding site [chemical binding]; other site
360115000762	Switch I region; other site
360115000763	G2 box; other site
360115000764	G3 box; other site
360115000765	Switch II region; other site
360115000766	G4 box; other site
360115000767	G5 box; other site
360115000768	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
360115000769	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
360115000770	Antibiotic Binding Site [chemical binding]; other site
360115000771	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
360115000772	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
360115000773	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
360115000774	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
360115000775	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
360115000776	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
360115000777	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
360115000778	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
360115000779	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
360115000780	protein-rRNA interface [nucleotide binding]; other site
360115000781	putative translocon binding site; other site
360115000782	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
360115000783	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
360115000784	G-X-X-G motif; other site
360115000785	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
360115000786	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
360115000787	23S rRNA interface [nucleotide binding]; other site
360115000788	5S rRNA interface [nucleotide binding]; other site
360115000789	putative antibiotic binding site [chemical binding]; other site
360115000790	L25 interface [polypeptide binding]; other site
360115000791	L27 interface [polypeptide binding]; other site
360115000792	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
360115000793	L23 interface [polypeptide binding]; other site
360115000794	signal recognition particle (SRP54) interaction site; other site
360115000795	trigger factor interaction site; other site
360115000796	23S rRNA interface [nucleotide binding]; other site
360115000797	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
360115000798	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
360115000799	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
360115000800	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
360115000801	RNA binding site [nucleotide binding]; other site
360115000802	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
360115000803	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
360115000804	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
360115000805	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
360115000806	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
360115000807	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
360115000808	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
360115000809	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
360115000810	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
360115000811	5S rRNA interface [nucleotide binding]; other site
360115000812	23S rRNA interface [nucleotide binding]; other site
360115000813	L5 interface [polypeptide binding]; other site
360115000814	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
360115000815	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
360115000816	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
360115000817	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
360115000818	23S rRNA binding site [nucleotide binding]; other site
360115000819	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
360115000820	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
360115000821	SecY translocase; Region: SecY; pfam00344
360115000822	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
360115000823	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
360115000824	30S ribosomal protein S13; Region: bact_S13; TIGR03631
360115000825	30S ribosomal protein S11; Validated; Region: PRK05309
360115000826	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
360115000827	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
360115000828	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
360115000829	RNA binding surface [nucleotide binding]; other site
360115000830	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
360115000831	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
360115000832	alphaNTD homodimer interface [polypeptide binding]; other site
360115000833	alphaNTD - beta interaction site [polypeptide binding]; other site
360115000834	alphaNTD - beta' interaction site [polypeptide binding]; other site
360115000835	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
360115000836	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
360115000837	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
360115000838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000839	putative substrate translocation pore; other site
360115000840	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
360115000841	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
360115000842	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
360115000843	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
360115000844	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
360115000845	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
360115000846	dimer interface [polypeptide binding]; other site
360115000847	ssDNA binding site [nucleotide binding]; other site
360115000848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
360115000849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115000850	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115000851	putative substrate translocation pore; other site
360115000852	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
360115000853	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
360115000854	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
360115000855	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
360115000856	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
360115000857	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
360115000858	substrate binding site [chemical binding]; other site
360115000859	active site
360115000860	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
360115000861	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
360115000862	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
360115000863	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
360115000864	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
360115000865	Amidinotransferase; Region: Amidinotransf; pfam02274
360115000866	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
360115000867	active site
360115000868	DNA polymerase IV; Validated; Region: PRK02406
360115000869	DNA binding site [nucleotide binding]
360115000870	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
360115000871	heme binding pocket [chemical binding]; other site
360115000872	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
360115000873	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
360115000874	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
360115000875	poly(A) polymerase; Region: pcnB; TIGR01942
360115000876	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
360115000877	active site
360115000878	NTP binding site [chemical binding]; other site
360115000879	metal binding triad [ion binding]; metal-binding site
360115000880	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
360115000881	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
360115000882	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
360115000883	catalytic center binding site [active]
360115000884	ATP binding site [chemical binding]; other site
360115000885	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
360115000886	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
360115000887	active site
360115000888	(T/H)XGH motif; other site
360115000889	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
360115000890	Ribosomal protein L33; Region: Ribosomal_L33; pfam00471
360115000891	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
360115000892	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
360115000893	trimer interface [polypeptide binding]; other site
360115000894	active site
360115000895	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
360115000896	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
360115000897	active site
360115000898	substrate binding site [chemical binding]; other site
360115000899	metal binding site [ion binding]; metal-binding site
360115000900	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
360115000901	active site
360115000902	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
360115000903	putative active site [active]
360115000904	putative catalytic site [active]
360115000905	putative DNA binding site [nucleotide binding]; other site
360115000906	putative phosphate binding site [ion binding]; other site
360115000907	metal binding site A [ion binding]; metal-binding site
360115000908	putative AP binding site [nucleotide binding]; other site
360115000909	putative metal binding site B [ion binding]; other site
360115000910	glutamate racemase; Provisional; Region: PRK00865
360115000911	ribonuclease PH; Reviewed; Region: rph; PRK00173
360115000912	Ribonuclease PH; Region: RNase_PH_bact; cd11362
360115000913	hexamer interface [polypeptide binding]; other site
360115000914	active site
360115000915	hypothetical protein; Provisional; Region: PRK11820
360115000916	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
360115000917	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
360115000918	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
360115000919	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
360115000920	catalytic site [active]
360115000921	G-X2-G-X-G-K; other site
360115000922	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
360115000923	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
360115000924	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
360115000925	Zn2+ binding site [ion binding]; other site
360115000926	Mg2+ binding site [ion binding]; other site
360115000927	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
360115000928	synthetase active site [active]
360115000929	NTP binding site [chemical binding]; other site
360115000930	metal binding site [ion binding]; metal-binding site
360115000931	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
360115000932	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
360115000933	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
360115000934	homotrimer interaction site [polypeptide binding]; other site
360115000935	putative active site [active]
360115000936	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
360115000937	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
360115000938	generic binding surface II; other site
360115000939	ssDNA binding site; other site
360115000940	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
360115000941	ATP binding site [chemical binding]; other site
360115000942	putative Mg++ binding site [ion binding]; other site
360115000943	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
360115000944	nucleotide binding region [chemical binding]; other site
360115000945	ATP-binding site [chemical binding]; other site
360115000946	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
360115000947	heat shock protein 90; Provisional; Region: PRK05218
360115000948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115000949	ATP binding site [chemical binding]; other site
360115000950	Mg2+ binding site [ion binding]; other site
360115000951	G-X-G motif; other site
360115000952	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
360115000953	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
360115000954	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
360115000955	homodimer interface [polypeptide binding]; other site
360115000956	NADP binding site [chemical binding]; other site
360115000957	substrate binding site [chemical binding]; other site
360115000958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
360115000959	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
360115000960	N-acetyl-D-glucosamine binding site [chemical binding]; other site
360115000961	catalytic residue [active]
360115000962	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
360115000963	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
360115000964	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
360115000965	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
360115000966	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
360115000967	Methyltransferase domain; Region: Methyltransf_23; pfam13489
360115000968	Methyltransferase domain; Region: Methyltransf_11; pfam08241
360115000969	DNA methylase; Region: N6_N4_Mtase; cl17433
360115000970	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
360115000971	RNA/DNA hybrid binding site [nucleotide binding]; other site
360115000972	active site
360115000973	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
360115000974	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
360115000975	active site
360115000976	catalytic site [active]
360115000977	substrate binding site [chemical binding]; other site
360115000978	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115000979	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
360115000980	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
360115000981	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
360115000982	Phosphopantetheine attachment site; Region: PP-binding; cl09936
360115000983	acyl-CoA synthetase; Validated; Region: PRK05850
360115000984	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
360115000985	acyl-activating enzyme (AAE) consensus motif; other site
360115000986	active site
360115000987	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
360115000988	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
360115000989	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
360115000990	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
360115000991	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
360115000992	ThiC-associated domain; Region: ThiC-associated; pfam13667
360115000993	ThiC family; Region: ThiC; pfam01964
360115000994	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
360115000995	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
360115000996	ThiS interaction site; other site
360115000997	putative active site [active]
360115000998	tetramer interface [polypeptide binding]; other site
360115000999	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
360115001000	dimer interface [polypeptide binding]; other site
360115001001	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
360115001002	substrate binding site [chemical binding]; other site
360115001003	ATP binding site [chemical binding]; other site
360115001004	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
360115001005	thiamine phosphate binding site [chemical binding]; other site
360115001006	active site
360115001007	pyrophosphate binding site [ion binding]; other site
360115001008	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767
360115001009	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
360115001010	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
360115001011	purine monophosphate binding site [chemical binding]; other site
360115001012	dimer interface [polypeptide binding]; other site
360115001013	putative catalytic residues [active]
360115001014	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
360115001015	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
360115001016	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
360115001017	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
360115001018	aminopeptidase N; Provisional; Region: pepN; PRK14015
360115001019	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
360115001020	active site
360115001021	Zn binding site [ion binding]; other site
360115001022	6-phosphofructokinase; Provisional; Region: PRK03202
360115001023	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
360115001024	active site
360115001025	ADP/pyrophosphate binding site [chemical binding]; other site
360115001026	dimerization interface [polypeptide binding]; other site
360115001027	allosteric effector site; other site
360115001028	fructose-1,6-bisphosphate binding site; other site
360115001029	xylose isomerase; Provisional; Region: PRK05474
360115001030	xylose isomerase; Region: xylose_isom_A; TIGR02630
360115001031	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
360115001032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115001033	putative substrate translocation pore; other site
360115001034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115001035	motif II; other site
360115001036	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
360115001037	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
360115001038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115001039	S-adenosylmethionine binding site [chemical binding]; other site
360115001040	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
360115001041	putative binding surface; other site
360115001042	active site
360115001043	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
360115001044	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
360115001045	putative inner membrane peptidase; Provisional; Region: PRK11778
360115001046	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
360115001047	tandem repeat interface [polypeptide binding]; other site
360115001048	oligomer interface [polypeptide binding]; other site
360115001049	active site residues [active]
360115001050	amino acid transporter; Region: 2A0306; TIGR00909
360115001051	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
360115001052	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
360115001053	metal binding site [ion binding]; metal-binding site
360115001054	dimer interface [polypeptide binding]; other site
360115001055	Peptidase family U32; Region: Peptidase_U32; cl03113
360115001056	phosphate:H+ symporter; Region: 2A0109; TIGR00887
360115001057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115001058	putative substrate translocation pore; other site
360115001059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115001060	dimer interface [polypeptide binding]; other site
360115001061	phosphorylation site [posttranslational modification]
360115001062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115001063	ATP binding site [chemical binding]; other site
360115001064	Mg2+ binding site [ion binding]; other site
360115001065	G-X-G motif; other site
360115001066	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
360115001067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115001068	active site
360115001069	phosphorylation site [posttranslational modification]
360115001070	intermolecular recognition site; other site
360115001071	dimerization interface [polypeptide binding]; other site
360115001072	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
360115001073	DNA binding site [nucleotide binding]
360115001074	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
360115001075	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
360115001076	Fic/DOC family; Region: Fic; pfam02661
360115001077	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
360115001078	putative active site [active]
360115001079	putative catalytic site [active]
360115001080	hypothetical protein; Provisional; Region: PRK07505
360115001081	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
360115001082	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
360115001083	amidase catalytic site [active]
360115001084	Zn binding residues [ion binding]; other site
360115001085	substrate binding site [chemical binding]; other site
360115001086	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
360115001087	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
360115001088	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
360115001089	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
360115001090	substrate binding pocket [chemical binding]; other site
360115001091	chain length determination region; other site
360115001092	substrate-Mg2+ binding site; other site
360115001093	catalytic residues [active]
360115001094	aspartate-rich region 1; other site
360115001095	active site lid residues [active]
360115001096	aspartate-rich region 2; other site
360115001097	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
360115001098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001099	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001100	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001101	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
360115001102	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
360115001103	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
360115001104	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
360115001105	GTP1/OBG; Region: GTP1_OBG; pfam01018
360115001106	Obg GTPase; Region: Obg; cd01898
360115001107	G1 box; other site
360115001108	GTP/Mg2+ binding site [chemical binding]; other site
360115001109	Switch I region; other site
360115001110	G2 box; other site
360115001111	G3 box; other site
360115001112	Switch II region; other site
360115001113	G4 box; other site
360115001114	G5 box; other site
360115001115	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
360115001116	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
360115001117	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
360115001118	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
360115001119	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
360115001120	active site
360115001121	Riboflavin kinase; Region: Flavokinase; smart00904
360115001122	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
360115001123	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
360115001124	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
360115001125	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
360115001126	active site
360115001127	HIGH motif; other site
360115001128	nucleotide binding site [chemical binding]; other site
360115001129	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
360115001130	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
360115001131	active site
360115001132	KMSKS motif; other site
360115001133	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
360115001134	tRNA binding surface [nucleotide binding]; other site
360115001135	anticodon binding site; other site
360115001136	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
360115001137	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
360115001138	lipoprotein signal peptidase; Provisional; Region: PRK14787
360115001139	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
360115001140	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
360115001141	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
360115001142	nucleoside/Zn binding site; other site
360115001143	dimer interface [polypeptide binding]; other site
360115001144	catalytic motif [active]
360115001145	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
360115001146	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
360115001147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115001148	catalytic residue [active]
360115001149	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
360115001150	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
360115001151	NodB motif; other site
360115001152	putative active site [active]
360115001153	putative catalytic site [active]
360115001154	putative Zn binding site [ion binding]; other site
360115001155	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
360115001156	tetramerization interface [polypeptide binding]; other site
360115001157	active site
360115001158	pantoate--beta-alanine ligase; Region: panC; TIGR00018
360115001159	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
360115001160	active site
360115001161	nucleotide binding site [chemical binding]; other site
360115001162	HIGH motif; other site
360115001163	KMSKS motif; other site
360115001164	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
360115001165	oligomerization interface [polypeptide binding]; other site
360115001166	active site
360115001167	metal binding site [ion binding]; metal-binding site
360115001168	amino acid transporter; Region: 2A0306; TIGR00909
360115001169	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
360115001170	hypothetical protein; Provisional; Region: PRK09256
360115001171	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
360115001172	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
360115001173	dimer interface [polypeptide binding]; other site
360115001174	putative anticodon binding site; other site
360115001175	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
360115001176	motif 1; other site
360115001177	active site
360115001178	motif 2; other site
360115001179	motif 3; other site
360115001180	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
360115001181	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
360115001182	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
360115001183	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115001184	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115001185	putative substrate translocation pore; other site
360115001186	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
360115001187	Mechanosensitive ion channel; Region: MS_channel; pfam00924
360115001188	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
360115001189	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
360115001190	DNA binding site [nucleotide binding]
360115001191	active site
360115001192	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
360115001193	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
360115001194	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
360115001195	RimM N-terminal domain; Region: RimM; pfam01782
360115001196	PRC-barrel domain; Region: PRC; pfam05239
360115001197	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14523
360115001198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001199	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001200	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001201	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115001202	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115001203	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
360115001204	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115001205	signal recognition particle protein; Provisional; Region: PRK10867
360115001206	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
360115001207	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
360115001208	P loop; other site
360115001209	GTP binding site [chemical binding]; other site
360115001210	Signal peptide binding domain; Region: SRP_SPB; pfam02978
360115001211	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
360115001212	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
360115001213	Domain of unknown function DUF21; Region: DUF21; pfam01595
360115001214	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
360115001215	Transporter associated domain; Region: CorC_HlyC; smart01091
360115001216	Type II transport protein GspH; Region: GspH; pfam12019
360115001217	adenylate kinase; Reviewed; Region: adk; PRK00279
360115001218	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
360115001219	AMP-binding site [chemical binding]; other site
360115001220	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
360115001221	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
360115001222	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
360115001223	catalytic residues [active]
360115001224	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
360115001225	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
360115001226	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
360115001227	CobD/Cbib protein; Region: CobD_Cbib; cl00561
360115001228	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
360115001229	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
360115001230	dimer interface [polypeptide binding]; other site
360115001231	TPP-binding site [chemical binding]; other site
360115001232	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
360115001233	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
360115001234	E3 interaction surface; other site
360115001235	lipoyl attachment site [posttranslational modification]; other site
360115001236	e3 binding domain; Region: E3_binding; pfam02817
360115001237	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
360115001238	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
360115001239	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
360115001240	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
360115001241	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
360115001242	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
360115001243	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
360115001244	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
360115001245	active site
360115001246	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
360115001247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115001248	S-adenosylmethionine binding site [chemical binding]; other site
360115001249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
360115001250	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
360115001251	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
360115001252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
360115001253	active site
360115001254	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
360115001255	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
360115001256	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
360115001257	ATP binding site [chemical binding]; other site
360115001258	putative Mg++ binding site [ion binding]; other site
360115001259	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
360115001260	nucleotide binding region [chemical binding]; other site
360115001261	ATP-binding site [chemical binding]; other site
360115001262	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
360115001263	HRDC domain; Region: HRDC; pfam00570
360115001264	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
360115001265	IHF dimer interface [polypeptide binding]; other site
360115001266	IHF - DNA interface [nucleotide binding]; other site
360115001267	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
360115001268	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
360115001269	Ligand binding site; other site
360115001270	oligomer interface; other site
360115001271	arginine repressor; Provisional; Region: PRK05066
360115001272	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
360115001273	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
360115001274	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
360115001275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115001276	Walker A/P-loop; other site
360115001277	ATP binding site [chemical binding]; other site
360115001278	Q-loop/lid; other site
360115001279	ABC transporter signature motif; other site
360115001280	Walker B; other site
360115001281	D-loop; other site
360115001282	H-loop/switch region; other site
360115001283	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
360115001284	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
360115001285	substrate binding pocket [chemical binding]; other site
360115001286	membrane-bound complex binding site; other site
360115001287	hinge residues; other site
360115001288	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
360115001289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115001290	dimer interface [polypeptide binding]; other site
360115001291	conserved gate region; other site
360115001292	putative PBP binding loops; other site
360115001293	ABC-ATPase subunit interface; other site
360115001294	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
360115001295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115001296	dimer interface [polypeptide binding]; other site
360115001297	conserved gate region; other site
360115001298	putative PBP binding loops; other site
360115001299	ABC-ATPase subunit interface; other site
360115001300	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
360115001301	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
360115001302	homodimer interface [polypeptide binding]; other site
360115001303	oligonucleotide binding site [chemical binding]; other site
360115001304	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
360115001305	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
360115001306	RNA binding surface [nucleotide binding]; other site
360115001307	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
360115001308	active site
360115001309	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
360115001310	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
360115001311	active site
360115001312	metal binding site [ion binding]; metal-binding site
360115001313	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
360115001314	dimerization interface [polypeptide binding]; other site
360115001315	substrate binding site [chemical binding]; other site
360115001316	active site
360115001317	calcium binding site [ion binding]; other site
360115001318	hypothetical protein; Provisional; Region: PRK08609
360115001319	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
360115001320	active site
360115001321	primer binding site [nucleotide binding]; other site
360115001322	NTP  binding site [chemical binding]; other site
360115001323	metal binding triad [ion binding]; metal-binding site
360115001324	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
360115001325	active site
360115001326	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
360115001327	putative phosphate acyltransferase; Provisional; Region: PRK05331
360115001328	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
360115001329	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
360115001330	dimer interface [polypeptide binding]; other site
360115001331	active site
360115001332	CoA binding pocket [chemical binding]; other site
360115001333	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
360115001334	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
360115001335	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
360115001336	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
360115001337	NAD(P) binding site [chemical binding]; other site
360115001338	homotetramer interface [polypeptide binding]; other site
360115001339	homodimer interface [polypeptide binding]; other site
360115001340	active site
360115001341	acyl carrier protein; Provisional; Region: acpP; PRK00982
360115001342	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
360115001343	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
360115001344	dimer interface [polypeptide binding]; other site
360115001345	active site
360115001346	YceG-like family; Region: YceG; pfam02618
360115001347	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
360115001348	dimerization interface [polypeptide binding]; other site
360115001349	thymidylate kinase; Validated; Region: tmk; PRK00698
360115001350	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
360115001351	TMP-binding site; other site
360115001352	ATP-binding site [chemical binding]; other site
360115001353	DNA polymerase III subunit delta'; Validated; Region: PRK05707
360115001354	DNA polymerase III subunit delta'; Validated; Region: PRK08485
360115001355	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
360115001356	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
360115001357	active site
360115001358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001359	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001360	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001361	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
360115001362	glutamine synthetase; Region: PLN02284
360115001363	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
360115001364	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
360115001365	POT family; Region: PTR2; cl17359
360115001366	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
360115001367	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
360115001368	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
360115001369	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
360115001370	DHH family; Region: DHH; pfam01368
360115001371	DHHA1 domain; Region: DHHA1; pfam02272
360115001372	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
360115001373	Trp operon repressor; Provisional; Region: PRK01381
360115001374	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
360115001375	Ceramidase; Region: Ceramidase; pfam05875
360115001376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115001377	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115001378	putative substrate translocation pore; other site
360115001379	aspartate aminotransferase; Provisional; Region: PRK05764
360115001380	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
360115001381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115001382	homodimer interface [polypeptide binding]; other site
360115001383	catalytic residue [active]
360115001384	excinuclease ABC subunit B; Provisional; Region: PRK05298
360115001385	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
360115001386	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
360115001387	ATP-binding site [chemical binding]; other site
360115001388	ATP binding site [chemical binding]; other site
360115001389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
360115001390	nucleotide binding region [chemical binding]; other site
360115001391	ATP-binding site [chemical binding]; other site
360115001392	Ultra-violet resistance protein B; Region: UvrB; pfam12344
360115001393	UvrB/uvrC motif; Region: UVR; pfam02151
360115001394	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
360115001395	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
360115001396	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
360115001397	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
360115001398	active site
360115001399	catalytic residues [active]
360115001400	metal binding site [ion binding]; metal-binding site
360115001401	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
360115001402	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
360115001403	active site
360115001404	putative substrate binding pocket [chemical binding]; other site
360115001405	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001406	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001407	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001408	DNA gyrase subunit A; Validated; Region: PRK05560
360115001409	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
360115001410	CAP-like domain; other site
360115001411	active site
360115001412	primary dimer interface [polypeptide binding]; other site
360115001413	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
360115001414	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
360115001415	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
360115001416	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
360115001417	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
360115001418	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
360115001419	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
360115001420	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
360115001421	catalytic residue [active]
360115001422	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
360115001423	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
360115001424	hinge; other site
360115001425	active site
360115001426	cytidylate kinase; Provisional; Region: cmk; PRK00023
360115001427	AAA domain; Region: AAA_17; pfam13207
360115001428	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
360115001429	CMP-binding site; other site
360115001430	The sites determining sugar specificity; other site
360115001431	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
360115001432	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
360115001433	RNA binding site [nucleotide binding]; other site
360115001434	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
360115001435	RNA binding site [nucleotide binding]; other site
360115001436	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
360115001437	RNA binding site [nucleotide binding]; other site
360115001438	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
360115001439	RNA binding site [nucleotide binding]; other site
360115001440	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
360115001441	RNA binding site [nucleotide binding]; other site
360115001442	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
360115001443	RNA binding site [nucleotide binding]; other site
360115001444	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
360115001445	tetratricopeptide repeat protein; Provisional; Region: PRK11788
360115001446	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115001447	binding surface
360115001448	TPR motif; other site
360115001449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115001450	binding surface
360115001451	TPR motif; other site
360115001452	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115001453	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
360115001454	active site
360115001455	dimer interface [polypeptide binding]; other site
360115001456	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
360115001457	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
360115001458	Mg++ binding site [ion binding]; other site
360115001459	putative catalytic motif [active]
360115001460	substrate binding site [chemical binding]; other site
360115001461	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
360115001462	Sel1-like repeats; Region: SEL1; smart00671
360115001463	cell division protein DamX; Validated; Region: PRK10905
360115001464	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
360115001465	POT family; Region: PTR2; cl17359
360115001466	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
360115001467	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
360115001468	Walker A/P-loop; other site
360115001469	ATP binding site [chemical binding]; other site
360115001470	Q-loop/lid; other site
360115001471	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
360115001472	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
360115001473	ABC transporter signature motif; other site
360115001474	Walker B; other site
360115001475	D-loop; other site
360115001476	H-loop/switch region; other site
360115001477	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
360115001478	FtsZ protein binding site [polypeptide binding]; other site
360115001479	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
360115001480	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
360115001481	nucleotide binding pocket [chemical binding]; other site
360115001482	K-X-D-G motif; other site
360115001483	catalytic site [active]
360115001484	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
360115001485	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
360115001486	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
360115001487	Dimer interface [polypeptide binding]; other site
360115001488	BRCT sequence motif; other site
360115001489	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
360115001490	heat shock protein HtpX; Provisional; Region: PRK02870
360115001491	Tetratricopeptide repeat; Region: TPR_16; pfam13432
360115001492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115001493	binding surface
360115001494	TPR motif; other site
360115001495	TPR repeat; Region: TPR_11; pfam13414
360115001496	TPR repeat; Region: TPR_11; pfam13414
360115001497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115001498	binding surface
360115001499	TPR motif; other site
360115001500	TPR repeat; Region: TPR_11; pfam13414
360115001501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115001502	binding surface
360115001503	TPR motif; other site
360115001504	TPR repeat; Region: TPR_11; pfam13414
360115001505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115001506	binding surface
360115001507	TPR motif; other site
360115001508	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
360115001509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
360115001510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115001511	S-adenosylmethionine binding site [chemical binding]; other site
360115001512	Transglycosylase SLT domain; Region: SLT_2; pfam13406
360115001513	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
360115001514	N-acetyl-D-glucosamine binding site [chemical binding]; other site
360115001515	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
360115001516	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
360115001517	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
360115001518	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
360115001519	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
360115001520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001521	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001522	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001523	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
360115001524	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
360115001525	active site
360115001526	(T/H)XGH motif; other site
360115001527	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
360115001528	DNA polymerase III, delta subunit; Region: holA; TIGR01128
360115001529	Lipopolysaccharide-assembly; Region: LptE; cl01125
360115001530	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
360115001531	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
360115001532	HIGH motif; other site
360115001533	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
360115001534	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
360115001535	active site
360115001536	KMSKS motif; other site
360115001537	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
360115001538	tRNA binding surface [nucleotide binding]; other site
360115001539	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
360115001540	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
360115001541	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115001542	AAA domain; Region: AAA_14; pfam13173
360115001543	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
360115001544	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
360115001545	putative active site [active]
360115001546	catalytic triad [active]
360115001547	putative dimer interface [polypeptide binding]; other site
360115001548	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
360115001549	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
360115001550	Transporter associated domain; Region: CorC_HlyC; smart01091
360115001551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115001552	putative substrate translocation pore; other site
360115001553	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115001554	metal-binding heat shock protein; Provisional; Region: PRK00016
360115001555	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
360115001556	PhoH-like protein; Region: PhoH; pfam02562
360115001557	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
360115001558	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
360115001559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115001560	FeS/SAM binding site; other site
360115001561	TRAM domain; Region: TRAM; pfam01938
360115001562	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
360115001563	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
360115001564	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
360115001565	interface (dimer of trimers) [polypeptide binding]; other site
360115001566	Substrate-binding/catalytic site; other site
360115001567	Zn-binding sites [ion binding]; other site
360115001568	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
360115001569	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
360115001570	active site
360115001571	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
360115001572	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
360115001573	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
360115001574	dimer interface [polypeptide binding]; other site
360115001575	active site
360115001576	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
360115001577	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
360115001578	substrate binding site [chemical binding]; other site
360115001579	oxyanion hole (OAH) forming residues; other site
360115001580	trimer interface [polypeptide binding]; other site
360115001581	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
360115001582	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
360115001583	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
360115001584	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
360115001585	Ligand binding site; other site
360115001586	Putative Catalytic site; other site
360115001587	DXD motif; other site
360115001588	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
360115001589	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
360115001590	putative active site [active]
360115001591	YdjC motif; other site
360115001592	Mg binding site [ion binding]; other site
360115001593	putative homodimer interface [polypeptide binding]; other site
360115001594	Ferredoxin [Energy production and conversion]; Region: COG1146
360115001595	4Fe-4S binding domain; Region: Fer4; pfam00037
360115001596	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
360115001597	BolA-like protein; Region: BolA; pfam01722
360115001598	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
360115001599	putative GSH binding site [chemical binding]; other site
360115001600	catalytic residues [active]
360115001601	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
360115001602	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
360115001603	FAD binding pocket [chemical binding]; other site
360115001604	FAD binding motif [chemical binding]; other site
360115001605	phosphate binding motif [ion binding]; other site
360115001606	beta-alpha-beta structure motif; other site
360115001607	NAD binding pocket [chemical binding]; other site
360115001608	Iron coordination center [ion binding]; other site
360115001609	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
360115001610	active site residue [active]
360115001611	quinolinate synthetase; Provisional; Region: PRK09375
360115001612	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
360115001613	dimer interface [polypeptide binding]; other site
360115001614	[2Fe-2S] cluster binding site [ion binding]; other site
360115001615	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
360115001616	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
360115001617	HemN family oxidoreductase; Provisional; Region: PRK05660
360115001618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115001619	FeS/SAM binding site; other site
360115001620	HemN C-terminal domain; Region: HemN_C; pfam06969
360115001621	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
360115001622	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
360115001623	active site
360115001624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001625	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001626	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001627	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
360115001628	diphosphomevalonate decarboxylase; Region: PLN02407
360115001629	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
360115001630	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
360115001631	active site
360115001632	metal binding site [ion binding]; metal-binding site
360115001633	nudix motif; other site
360115001634	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
360115001635	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
360115001636	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
360115001637	mevalonate kinase; Region: mevalon_kin; TIGR00549
360115001638	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
360115001639	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
360115001640	homodimer interface [polypeptide binding]; other site
360115001641	substrate binding pocket [chemical binding]; other site
360115001642	catalytic residues [active]
360115001643	NADH/NADPH cofactor binding site [chemical binding]; other site
360115001644	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
360115001645	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
360115001646	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
360115001647	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
360115001648	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
360115001649	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
360115001650	Surface antigen; Region: Bac_surface_Ag; pfam01103
360115001651	periplasmic chaperone; Provisional; Region: PRK10780
360115001652	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
360115001653	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
360115001654	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
360115001655	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
360115001656	trimer interface [polypeptide binding]; other site
360115001657	active site
360115001658	UDP-GlcNAc binding site [chemical binding]; other site
360115001659	lipid binding site [chemical binding]; lipid-binding site
360115001660	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
360115001661	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
360115001662	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
360115001663	active site
360115001664	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
360115001665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
360115001666	active site
360115001667	motif I; other site
360115001668	motif II; other site
360115001669	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
360115001670	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
360115001671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001672	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115001673	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115001674	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
360115001675	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
360115001676	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
360115001677	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
360115001678	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
360115001679	nucleoside/Zn binding site; other site
360115001680	dimer interface [polypeptide binding]; other site
360115001681	catalytic motif [active]
360115001682	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
360115001683	dimer interface [polypeptide binding]; other site
360115001684	substrate binding site [chemical binding]; other site
360115001685	metal binding sites [ion binding]; metal-binding site
360115001686	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
360115001687	Proline dehydrogenase; Region: Pro_dh; pfam01619
360115001688	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
360115001689	Glutamate binding site [chemical binding]; other site
360115001690	NAD binding site [chemical binding]; other site
360115001691	catalytic residues [active]
360115001692	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
360115001693	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
360115001694	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
360115001695	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
360115001696	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
360115001697	dimerization interface [polypeptide binding]; other site
360115001698	ATP binding site [chemical binding]; other site
360115001699	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
360115001700	dimerization interface [polypeptide binding]; other site
360115001701	ATP binding site [chemical binding]; other site
360115001702	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
360115001703	putative active site [active]
360115001704	catalytic triad [active]
360115001705	Uncharacterized conserved protein [Function unknown]; Region: COG3461
360115001706	PAS domain; Region: PAS; smart00091
360115001707	PAS domain; Region: PAS_9; pfam13426
360115001708	putative active site [active]
360115001709	heme pocket [chemical binding]; other site
360115001710	PAS fold; Region: PAS_4; pfam08448
360115001711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
360115001712	putative active site [active]
360115001713	heme pocket [chemical binding]; other site
360115001714	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115001715	dimer interface [polypeptide binding]; other site
360115001716	phosphorylation site [posttranslational modification]
360115001717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115001718	ATP binding site [chemical binding]; other site
360115001719	Mg2+ binding site [ion binding]; other site
360115001720	G-X-G motif; other site
360115001721	Response regulator receiver domain; Region: Response_reg; pfam00072
360115001722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115001723	active site
360115001724	phosphorylation site [posttranslational modification]
360115001725	intermolecular recognition site; other site
360115001726	dimerization interface [polypeptide binding]; other site
360115001727	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
360115001728	EamA-like transporter family; Region: EamA; pfam00892
360115001729	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
360115001730	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
360115001731	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
360115001732	E3 interaction surface; other site
360115001733	lipoyl attachment site [posttranslational modification]; other site
360115001734	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
360115001735	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
360115001736	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
360115001737	alpha subunit interface [polypeptide binding]; other site
360115001738	TPP binding site [chemical binding]; other site
360115001739	heterodimer interface [polypeptide binding]; other site
360115001740	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
360115001741	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
360115001742	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
360115001743	TPP-binding site [chemical binding]; other site
360115001744	tetramer interface [polypeptide binding]; other site
360115001745	heterodimer interface [polypeptide binding]; other site
360115001746	phosphorylation loop region [posttranslational modification]
360115001747	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
360115001748	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
360115001749	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
360115001750	NAD binding site [chemical binding]; other site
360115001751	Phe binding site; other site
360115001752	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
360115001753	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
360115001754	putative active site [active]
360115001755	catalytic site [active]
360115001756	putative metal binding site [ion binding]; other site
360115001757	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
360115001758	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
360115001759	catalytic motif [active]
360115001760	Zn binding site [ion binding]; other site
360115001761	RibD C-terminal domain; Region: RibD_C; cl17279
360115001762	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
360115001763	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
360115001764	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
360115001765	Lumazine binding domain; Region: Lum_binding; pfam00677
360115001766	Lumazine binding domain; Region: Lum_binding; pfam00677
360115001767	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
360115001768	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
360115001769	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
360115001770	dimerization interface [polypeptide binding]; other site
360115001771	active site
360115001772	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
360115001773	homopentamer interface [polypeptide binding]; other site
360115001774	active site
360115001775	Domain of unknown function DUF20; Region: UPF0118; pfam01594
360115001776	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
360115001777	hypothetical protein; Validated; Region: PRK00153
360115001778	recombination protein RecR; Reviewed; Region: recR; PRK00076
360115001779	RecR protein; Region: RecR; pfam02132
360115001780	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
360115001781	putative active site [active]
360115001782	putative metal-binding site [ion binding]; other site
360115001783	tetramer interface [polypeptide binding]; other site
360115001784	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
360115001785	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14958
360115001786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115001787	Walker A motif; other site
360115001788	ATP binding site [chemical binding]; other site
360115001789	Walker B motif; other site
360115001790	arginine finger; other site
360115001791	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
360115001792	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
360115001793	AAA domain; Region: AAA_14; pfam13173
360115001794	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115001795	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
360115001796	Transposase [DNA replication, recombination, and repair]; Region: COG5433
360115001797	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
360115001798	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
360115001799	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
360115001800	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
360115001801	metal binding site [ion binding]; metal-binding site
360115001802	dimer interface [polypeptide binding]; other site
360115001803	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
360115001804	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
360115001805	trimer interface [polypeptide binding]; other site
360115001806	active site
360115001807	substrate binding site [chemical binding]; other site
360115001808	CoA binding site [chemical binding]; other site
360115001809	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
360115001810	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
360115001811	ATP binding site [chemical binding]; other site
360115001812	Mg++ binding site [ion binding]; other site
360115001813	motif III; other site
360115001814	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
360115001815	nucleotide binding region [chemical binding]; other site
360115001816	ATP-binding site [chemical binding]; other site
360115001817	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
360115001818	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
360115001819	Substrate binding site; other site
360115001820	Cupin domain; Region: Cupin_2; cl17218
360115001821	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
360115001822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115001823	active site
360115001824	motif I; other site
360115001825	motif II; other site
360115001826	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
360115001827	dimer interface [polypeptide binding]; other site
360115001828	active site
360115001829	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
360115001830	active site
360115001831	intersubunit interactions; other site
360115001832	catalytic residue [active]
360115001833	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
360115001834	extended (e) SDRs; Region: SDR_e; cd08946
360115001835	NAD(P) binding site [chemical binding]; other site
360115001836	active site
360115001837	substrate binding site [chemical binding]; other site
360115001838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
360115001839	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
360115001840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
360115001841	NAD(P) binding site [chemical binding]; other site
360115001842	active site
360115001843	N-terminal domain of RfaE; Region: RfaE_N; cd02172
360115001844	putative active site [active]
360115001845	(T/H)XGH motif; other site
360115001846	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
360115001847	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
360115001848	putative ribose interaction site [chemical binding]; other site
360115001849	putative ADP binding site [chemical binding]; other site
360115001850	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
360115001851	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
360115001852	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
360115001853	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
360115001854	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
360115001855	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
360115001856	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
360115001857	extended (e) SDRs; Region: SDR_e; cd08946
360115001858	NAD(P) binding site [chemical binding]; other site
360115001859	active site
360115001860	substrate binding site [chemical binding]; other site
360115001861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
360115001862	Methyltransferase domain; Region: Methyltransf_31; pfam13847
360115001863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115001864	S-adenosylmethionine binding site [chemical binding]; other site
360115001865	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
360115001866	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
360115001867	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
360115001868	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
360115001869	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
360115001870	NADP binding site [chemical binding]; other site
360115001871	active site
360115001872	putative substrate binding site [chemical binding]; other site
360115001873	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
360115001874	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
360115001875	NADP-binding site; other site
360115001876	homotetramer interface [polypeptide binding]; other site
360115001877	substrate binding site [chemical binding]; other site
360115001878	homodimer interface [polypeptide binding]; other site
360115001879	active site
360115001880	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
360115001881	active site
360115001882	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
360115001883	Methyltransferase domain; Region: Methyltransf_23; pfam13489
360115001884	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
360115001885	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
360115001886	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
360115001887	alpha subunit interface [polypeptide binding]; other site
360115001888	TPP binding site [chemical binding]; other site
360115001889	heterodimer interface [polypeptide binding]; other site
360115001890	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
360115001891	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
360115001892	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
360115001893	tetramer interface [polypeptide binding]; other site
360115001894	TPP-binding site [chemical binding]; other site
360115001895	heterodimer interface [polypeptide binding]; other site
360115001896	phosphorylation loop region [posttranslational modification]
360115001897	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
360115001898	active site
360115001899	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
360115001900	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
360115001901	inhibitor-cofactor binding pocket; inhibition site
360115001902	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115001903	catalytic residue [active]
360115001904	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
360115001905	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
360115001906	inhibitor-cofactor binding pocket; inhibition site
360115001907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115001908	catalytic residue [active]
360115001909	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
360115001910	ATP-sulfurylase; Region: ATPS; cd00517
360115001911	active site
360115001912	HXXH motif; other site
360115001913	flexible loop; other site
360115001914	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
360115001915	ligand-binding site [chemical binding]; other site
360115001916	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
360115001917	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
360115001918	active site
360115001919	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
360115001920	classical (c) SDRs; Region: SDR_c; cd05233
360115001921	NAD(P) binding site [chemical binding]; other site
360115001922	active site
360115001923	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
360115001924	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
360115001925	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
360115001926	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
360115001927	Walker A/P-loop; other site
360115001928	ATP binding site [chemical binding]; other site
360115001929	Q-loop/lid; other site
360115001930	ABC transporter signature motif; other site
360115001931	Walker B; other site
360115001932	D-loop; other site
360115001933	H-loop/switch region; other site
360115001934	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
360115001935	response regulator; Provisional; Region: PRK09483
360115001936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115001937	active site
360115001938	phosphorylation site [posttranslational modification]
360115001939	intermolecular recognition site; other site
360115001940	dimerization interface [polypeptide binding]; other site
360115001941	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
360115001942	DNA binding residues [nucleotide binding]
360115001943	dimerization interface [polypeptide binding]; other site
360115001944	phosphate:H+ symporter; Region: 2A0109; TIGR00887
360115001945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115001946	putative substrate translocation pore; other site
360115001947	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
360115001948	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
360115001949	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
360115001950	agmatinase; Region: agmatinase; TIGR01230
360115001951	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
360115001952	putative active site [active]
360115001953	Mn binding site [ion binding]; other site
360115001954	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
360115001955	deoxyhypusine synthase; Region: dhys; TIGR00321
360115001956	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
360115001957	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
360115001958	dimer interface [polypeptide binding]; other site
360115001959	active site
360115001960	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
360115001961	catalytic residues [active]
360115001962	substrate binding site [chemical binding]; other site
360115001963	AMIN domain; Region: AMIN; pfam11741
360115001964	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
360115001965	active site
360115001966	metal binding site [ion binding]; metal-binding site
360115001967	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
360115001968	PAS fold; Region: PAS_3; pfam08447
360115001969	putative active site [active]
360115001970	heme pocket [chemical binding]; other site
360115001971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
360115001972	PAS fold; Region: PAS_3; pfam08447
360115001973	putative active site [active]
360115001974	heme pocket [chemical binding]; other site
360115001975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115001976	dimer interface [polypeptide binding]; other site
360115001977	phosphorylation site [posttranslational modification]
360115001978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115001979	ATP binding site [chemical binding]; other site
360115001980	Mg2+ binding site [ion binding]; other site
360115001981	G-X-G motif; other site
360115001982	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
360115001983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115001984	active site
360115001985	phosphorylation site [posttranslational modification]
360115001986	intermolecular recognition site; other site
360115001987	dimerization interface [polypeptide binding]; other site
360115001988	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
360115001989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115001990	ATP binding site [chemical binding]; other site
360115001991	Mg2+ binding site [ion binding]; other site
360115001992	G-X-G motif; other site
360115001993	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
360115001994	ATP binding site [chemical binding]; other site
360115001995	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
360115001996	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
360115001997	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
360115001998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115001999	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115002000	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115002001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
360115002002	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115002003	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
360115002004	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
360115002005	beta-hexosaminidase; Provisional; Region: PRK05337
360115002006	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
360115002007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115002008	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115002009	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115002010	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
360115002011	Mechanosensitive ion channel; Region: MS_channel; pfam00924
360115002012	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
360115002013	active site
360115002014	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
360115002015	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
360115002016	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
360115002017	Predicted membrane protein [Function unknown]; Region: COG2259
360115002018	cyclase homology domain; Region: CHD; cd07302
360115002019	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
360115002020	nucleotidyl binding site; other site
360115002021	metal binding site [ion binding]; metal-binding site
360115002022	dimer interface [polypeptide binding]; other site
360115002023	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
360115002024	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
360115002025	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
360115002026	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
360115002027	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
360115002028	Ligand Binding Site [chemical binding]; other site
360115002029	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
360115002030	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
360115002031	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115002032	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
360115002033	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
360115002034	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
360115002035	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
360115002036	RNA binding surface [nucleotide binding]; other site
360115002037	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
360115002038	probable active site [active]
360115002039	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
360115002040	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
360115002041	MutS domain I; Region: MutS_I; pfam01624
360115002042	MutS domain II; Region: MutS_II; pfam05188
360115002043	MutS domain III; Region: MutS_III; pfam05192
360115002044	MutS domain V; Region: MutS_V; pfam00488
360115002045	Walker A/P-loop; other site
360115002046	ATP binding site [chemical binding]; other site
360115002047	Q-loop/lid; other site
360115002048	ABC transporter signature motif; other site
360115002049	Walker B; other site
360115002050	D-loop; other site
360115002051	H-loop/switch region; other site
360115002052	Competence-damaged protein; Region: CinA; pfam02464
360115002053	recombinase A; Provisional; Region: recA; PRK09354
360115002054	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
360115002055	hexamer interface [polypeptide binding]; other site
360115002056	Walker A motif; other site
360115002057	ATP binding site [chemical binding]; other site
360115002058	Walker B motif; other site
360115002059	recombination regulator RecX; Reviewed; Region: recX; PRK00117
360115002060	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
360115002061	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
360115002062	motif 1; other site
360115002063	active site
360115002064	motif 2; other site
360115002065	motif 3; other site
360115002066	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
360115002067	DHHA1 domain; Region: DHHA1; pfam02272
360115002068	aspartate kinase; Reviewed; Region: PRK06635
360115002069	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
360115002070	putative nucleotide binding site [chemical binding]; other site
360115002071	putative catalytic residues [active]
360115002072	putative Mg ion binding site [ion binding]; other site
360115002073	putative aspartate binding site [chemical binding]; other site
360115002074	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
360115002075	putative allosteric regulatory site; other site
360115002076	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
360115002077	putative allosteric regulatory residue; other site
360115002078	carbon storage regulator; Provisional; Region: PRK01712
360115002079	response regulator; Provisional; Region: PRK09483
360115002080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115002081	active site
360115002082	phosphorylation site [posttranslational modification]
360115002083	intermolecular recognition site; other site
360115002084	dimerization interface [polypeptide binding]; other site
360115002085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
360115002086	DNA binding residues [nucleotide binding]
360115002087	dimerization interface [polypeptide binding]; other site
360115002088	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
360115002089	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
360115002090	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
360115002091	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
360115002092	D-pathway; other site
360115002093	Putative ubiquinol binding site [chemical binding]; other site
360115002094	Low-spin heme (heme b) binding site [chemical binding]; other site
360115002095	Putative water exit pathway; other site
360115002096	Binuclear center (heme o3/CuB) [ion binding]; other site
360115002097	K-pathway; other site
360115002098	Putative proton exit pathway; other site
360115002099	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
360115002100	Subunit I/III interface [polypeptide binding]; other site
360115002101	Subunit III/IV interface [polypeptide binding]; other site
360115002102	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
360115002103	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
360115002104	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
360115002105	active site
360115002106	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
360115002107	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
360115002108	catalytic residue [active]
360115002109	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
360115002110	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
360115002111	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
360115002112	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115002113	Walker A motif; other site
360115002114	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
360115002115	active site
360115002116	NTP binding site [chemical binding]; other site
360115002117	metal binding triad [ion binding]; metal-binding site
360115002118	antibiotic binding site [chemical binding]; other site
360115002119	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
360115002120	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
360115002121	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
360115002122	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
360115002123	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
360115002124	inhibitor-cofactor binding pocket; inhibition site
360115002125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115002126	catalytic residue [active]
360115002127	biotin synthase; Region: bioB; TIGR00433
360115002128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115002129	FeS/SAM binding site; other site
360115002130	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
360115002131	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
360115002132	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
360115002133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
360115002134	catalytic residue [active]
360115002135	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
360115002136	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
360115002137	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115002138	S-adenosylmethionine binding site [chemical binding]; other site
360115002139	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
360115002140	Biotin operon repressor [Transcription]; Region: BirA; COG1654
360115002141	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
360115002142	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
360115002143	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
360115002144	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
360115002145	FtsX-like permease family; Region: FtsX; pfam02687
360115002146	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
360115002147	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
360115002148	Walker A/P-loop; other site
360115002149	ATP binding site [chemical binding]; other site
360115002150	Q-loop/lid; other site
360115002151	ABC transporter signature motif; other site
360115002152	Walker B; other site
360115002153	D-loop; other site
360115002154	H-loop/switch region; other site
360115002155	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
360115002156	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
360115002157	HflX GTPase family; Region: HflX; cd01878
360115002158	G1 box; other site
360115002159	GTP/Mg2+ binding site [chemical binding]; other site
360115002160	Switch I region; other site
360115002161	G2 box; other site
360115002162	G3 box; other site
360115002163	Switch II region; other site
360115002164	G4 box; other site
360115002165	G5 box; other site
360115002166	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
360115002167	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
360115002168	GDP-binding site [chemical binding]; other site
360115002169	ACT binding site; other site
360115002170	IMP binding site; other site
360115002171	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
360115002172	UbiA prenyltransferase family; Region: UbiA; pfam01040
360115002173	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
360115002174	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
360115002175	active site
360115002176	catalytic residues [active]
360115002177	metal binding site [ion binding]; metal-binding site
360115002178	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
360115002179	ligand binding site [chemical binding]; other site
360115002180	active site
360115002181	UGI interface [polypeptide binding]; other site
360115002182	catalytic site [active]
360115002183	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
360115002184	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
360115002185	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
360115002186	Sporulation related domain; Region: SPOR; pfam05036
360115002187	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
360115002188	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
360115002189	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
360115002190	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
360115002191	arogenate dehydrogenase; Region: PLN02256
360115002192	Chorismate mutase type II; Region: CM_2; cl00693
360115002193	Prephenate dehydratase; Region: PDT; pfam00800
360115002194	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
360115002195	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
360115002196	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
360115002197	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
360115002198	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
360115002199	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
360115002200	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
360115002201	carboxyltransferase (CT) interaction site; other site
360115002202	biotinylation site [posttranslational modification]; other site
360115002203	enoyl-CoA hydratase; Provisional; Region: PRK05995
360115002204	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
360115002205	substrate binding site [chemical binding]; other site
360115002206	oxyanion hole (OAH) forming residues; other site
360115002207	trimer interface [polypeptide binding]; other site
360115002208	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
360115002209	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
360115002210	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
360115002211	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
360115002212	dimer interface [polypeptide binding]; other site
360115002213	active site
360115002214	isovaleryl-CoA dehydrogenase; Region: PLN02519
360115002215	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
360115002216	substrate binding site [chemical binding]; other site
360115002217	FAD binding site [chemical binding]; other site
360115002218	catalytic base [active]
360115002219	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
360115002220	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
360115002221	quinone interaction residues [chemical binding]; other site
360115002222	active site
360115002223	catalytic residues [active]
360115002224	FMN binding site [chemical binding]; other site
360115002225	substrate binding site [chemical binding]; other site
360115002226	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
360115002227	PLD-like domain; Region: PLDc_2; pfam13091
360115002228	putative active site [active]
360115002229	catalytic site [active]
360115002230	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
360115002231	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
360115002232	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
360115002233	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
360115002234	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
360115002235	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
360115002236	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
360115002237	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
360115002238	catalytic triad [active]
360115002239	C factor cell-cell signaling protein; Provisional; Region: PRK09009
360115002240	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
360115002241	NADP binding site [chemical binding]; other site
360115002242	homodimer interface [polypeptide binding]; other site
360115002243	active site
360115002244	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
360115002245	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
360115002246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115002247	non-specific DNA binding site [nucleotide binding]; other site
360115002248	salt bridge; other site
360115002249	sequence-specific DNA binding site [nucleotide binding]; other site
360115002250	Cupin domain; Region: Cupin_2; pfam07883
360115002251	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
360115002252	response regulator; Provisional; Region: PRK09483
360115002253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115002254	active site
360115002255	phosphorylation site [posttranslational modification]
360115002256	intermolecular recognition site; other site
360115002257	dimerization interface [polypeptide binding]; other site
360115002258	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
360115002259	DNA binding residues [nucleotide binding]
360115002260	dimerization interface [polypeptide binding]; other site
360115002261	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
360115002262	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
360115002263	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
360115002264	Fic/DOC family; Region: Fic; pfam02661
360115002265	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
360115002266	active site residue [active]
360115002267	oxidative damage protection protein; Provisional; Region: PRK05408
360115002268	adenine DNA glycosylase; Provisional; Region: PRK10880
360115002269	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
360115002270	minor groove reading motif; other site
360115002271	helix-hairpin-helix signature motif; other site
360115002272	substrate binding pocket [chemical binding]; other site
360115002273	active site
360115002274	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
360115002275	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
360115002276	DNA binding and oxoG recognition site [nucleotide binding]
360115002277	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
360115002278	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
360115002279	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
360115002280	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
360115002281	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
360115002282	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
360115002283	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
360115002284	Walker A/P-loop; other site
360115002285	ATP binding site [chemical binding]; other site
360115002286	Q-loop/lid; other site
360115002287	ABC transporter signature motif; other site
360115002288	Walker B; other site
360115002289	D-loop; other site
360115002290	H-loop/switch region; other site
360115002291	inner membrane transport permease; Provisional; Region: PRK15066
360115002292	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
360115002293	glycerol kinase; Provisional; Region: glpK; PRK00047
360115002294	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
360115002295	N- and C-terminal domain interface [polypeptide binding]; other site
360115002296	active site
360115002297	MgATP binding site [chemical binding]; other site
360115002298	catalytic site [active]
360115002299	metal binding site [ion binding]; metal-binding site
360115002300	glycerol binding site [chemical binding]; other site
360115002301	homotetramer interface [polypeptide binding]; other site
360115002302	homodimer interface [polypeptide binding]; other site
360115002303	FBP binding site [chemical binding]; other site
360115002304	protein IIAGlc interface [polypeptide binding]; other site
360115002305	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
360115002306	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
360115002307	active site
360115002308	DNA binding site [nucleotide binding]
360115002309	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
360115002310	classical (c) SDRs; Region: SDR_c; cd05233
360115002311	NAD(P) binding site [chemical binding]; other site
360115002312	active site
360115002313	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
360115002314	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
360115002315	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
360115002316	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
360115002317	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
360115002318	lytic murein transglycosylase; Region: MltB_2; TIGR02283
360115002319	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
360115002320	N-acetyl-D-glucosamine binding site [chemical binding]; other site
360115002321	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
360115002322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115002323	S-adenosylmethionine binding site [chemical binding]; other site
360115002324	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
360115002325	Domain of unknown function DUF20; Region: UPF0118; pfam01594
360115002326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115002327	putative substrate translocation pore; other site
360115002328	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115002329	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
360115002330	Fatty acid desaturase; Region: FA_desaturase; pfam00487
360115002331	Di-iron ligands [ion binding]; other site
360115002332	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
360115002333	active site
360115002334	nucleophile elbow; other site
360115002335	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
360115002336	putative catalytic site [active]
360115002337	putative metal binding site [ion binding]; other site
360115002338	putative phosphate binding site [ion binding]; other site
360115002339	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
360115002340	CoenzymeA binding site [chemical binding]; other site
360115002341	subunit interaction site [polypeptide binding]; other site
360115002342	PHB binding site; other site
360115002343	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
360115002344	2-methylcitrate dehydratase; Region: prpD; TIGR02330
360115002345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115002346	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115002347	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115002348	Phosphotransferase enzyme family; Region: APH; pfam01636
360115002349	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
360115002350	active site
360115002351	ATP binding site [chemical binding]; other site
360115002352	substrate binding site [chemical binding]; other site
360115002353	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
360115002354	intracellular septation protein A; Reviewed; Region: PRK00259
360115002355	YciI-like protein; Reviewed; Region: PRK11370
360115002356	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
360115002357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115002358	putative substrate translocation pore; other site
360115002359	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115002360	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
360115002361	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
360115002362	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
360115002363	FMN binding site [chemical binding]; other site
360115002364	active site
360115002365	catalytic residues [active]
360115002366	substrate binding site [chemical binding]; other site
360115002367	Protein required for attachment to host cells; Region: Host_attach; pfam10116
360115002368	Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases; Region: TY; cd00191
360115002369	protease interaction site; other site
360115002370	amidophosphoribosyltransferase; Provisional; Region: PRK09246
360115002371	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
360115002372	tetramer interface [polypeptide binding]; other site
360115002373	active site
360115002374	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
360115002375	active site
360115002376	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
360115002377	Colicin V production protein; Region: Colicin_V; cl00567
360115002378	Sporulation related domain; Region: SPOR; pfam05036
360115002379	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
360115002380	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
360115002381	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
360115002382	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
360115002383	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
360115002384	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
360115002385	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
360115002386	dimerization interface 3.5A [polypeptide binding]; other site
360115002387	active site
360115002388	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
360115002389	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
360115002390	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
360115002391	Thioredoxin; Region: Thioredoxin_4; pfam13462
360115002392	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
360115002393	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
360115002394	Flavoprotein; Region: Flavoprotein; pfam02441
360115002395	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
360115002396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115002397	active site
360115002398	motif I; other site
360115002399	motif II; other site
360115002400	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
360115002401	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
360115002402	G1 box; other site
360115002403	putative GEF interaction site [polypeptide binding]; other site
360115002404	GTP/Mg2+ binding site [chemical binding]; other site
360115002405	Switch I region; other site
360115002406	G2 box; other site
360115002407	G3 box; other site
360115002408	Switch II region; other site
360115002409	G4 box; other site
360115002410	G5 box; other site
360115002411	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
360115002412	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
360115002413	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
360115002414	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
360115002415	ATP binding site [chemical binding]; other site
360115002416	substrate interface [chemical binding]; other site
360115002417	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
360115002418	active site residue [active]
360115002419	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
360115002420	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
360115002421	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
360115002422	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
360115002423	Tetramer interface [polypeptide binding]; other site
360115002424	active site
360115002425	FMN-binding site [chemical binding]; other site
360115002426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
360115002427	Smr domain; Region: Smr; pfam01713
360115002428	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
360115002429	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
360115002430	Sugar specificity; other site
360115002431	Pyrimidine base specificity; other site
360115002432	ATP-binding site [chemical binding]; other site
360115002433	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
360115002434	alanine racemase; Reviewed; Region: alr; PRK00053
360115002435	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
360115002436	active site
360115002437	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
360115002438	substrate binding site [chemical binding]; other site
360115002439	catalytic residues [active]
360115002440	dimer interface [polypeptide binding]; other site
360115002441	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
360115002442	AAA domain; Region: AAA_25; pfam13481
360115002443	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
360115002444	Walker A motif; other site
360115002445	ATP binding site [chemical binding]; other site
360115002446	Walker B motif; other site
360115002447	DNA binding loops [nucleotide binding]
360115002448	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
360115002449	protein-splicing catalytic site; other site
360115002450	thioester formation/cholesterol transfer; other site
360115002451	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115002452	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
360115002453	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
360115002454	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
360115002455	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
360115002456	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
360115002457	ankyrin-like protein; Provisional; Region: PHA03095
360115002458	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115002459	ankyrin repeat protein; Provisional; Region: PHA02875
360115002460	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
360115002461	NAD synthetase; Provisional; Region: PRK13981
360115002462	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
360115002463	multimer interface [polypeptide binding]; other site
360115002464	active site
360115002465	catalytic triad [active]
360115002466	protein interface 1 [polypeptide binding]; other site
360115002467	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
360115002468	homodimer interface [polypeptide binding]; other site
360115002469	NAD binding pocket [chemical binding]; other site
360115002470	ATP binding pocket [chemical binding]; other site
360115002471	Mg binding site [ion binding]; other site
360115002472	active-site loop [active]
360115002473	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
360115002474	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
360115002475	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
360115002476	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
360115002477	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
360115002478	Walker A/P-loop; other site
360115002479	ATP binding site [chemical binding]; other site
360115002480	Q-loop/lid; other site
360115002481	ABC transporter signature motif; other site
360115002482	Walker B; other site
360115002483	D-loop; other site
360115002484	H-loop/switch region; other site
360115002485	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
360115002486	active site
360115002487	dimer interfaces [polypeptide binding]; other site
360115002488	catalytic residues [active]
360115002489	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
360115002490	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
360115002491	RNase E interface [polypeptide binding]; other site
360115002492	trimer interface [polypeptide binding]; other site
360115002493	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
360115002494	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
360115002495	RNase E interface [polypeptide binding]; other site
360115002496	trimer interface [polypeptide binding]; other site
360115002497	active site
360115002498	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
360115002499	putative nucleic acid binding region [nucleotide binding]; other site
360115002500	G-X-X-G motif; other site
360115002501	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
360115002502	RNA binding site [nucleotide binding]; other site
360115002503	domain interface; other site
360115002504	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
360115002505	16S/18S rRNA binding site [nucleotide binding]; other site
360115002506	S13e-L30e interaction site [polypeptide binding]; other site
360115002507	25S rRNA binding site [nucleotide binding]; other site
360115002508	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
360115002509	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
360115002510	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
360115002511	active site
360115002512	tetramer interface; other site
360115002513	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
360115002514	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
360115002515	active site
360115002516	dimer interface [polypeptide binding]; other site
360115002517	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
360115002518	dimer interface [polypeptide binding]; other site
360115002519	active site
360115002520	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
360115002521	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
360115002522	NAD binding site [chemical binding]; other site
360115002523	homodimer interface [polypeptide binding]; other site
360115002524	homotetramer interface [polypeptide binding]; other site
360115002525	active site
360115002526	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
360115002527	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
360115002528	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
360115002529	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
360115002530	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
360115002531	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
360115002532	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
360115002533	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
360115002534	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
360115002535	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
360115002536	putative NAD(P) binding site [chemical binding]; other site
360115002537	active site
360115002538	putative substrate binding site [chemical binding]; other site
360115002539	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
360115002540	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
360115002541	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
360115002542	active site
360115002543	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
360115002544	homodimer interface [polypeptide binding]; other site
360115002545	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
360115002546	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
360115002547	putative ADP-binding pocket [chemical binding]; other site
360115002548	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
360115002549	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
360115002550	active site
360115002551	dimer interface [polypeptide binding]; other site
360115002552	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
360115002553	Ligand Binding Site [chemical binding]; other site
360115002554	Molecular Tunnel; other site
360115002555	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
360115002556	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
360115002557	putative ADP-binding pocket [chemical binding]; other site
360115002558	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
360115002559	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
360115002560	putative ADP-binding pocket [chemical binding]; other site
360115002561	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115002562	Radical SAM superfamily; Region: Radical_SAM; pfam04055
360115002563	FeS/SAM binding site; other site
360115002564	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
360115002565	Methyltransferase domain; Region: Methyltransf_31; pfam13847
360115002566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115002567	S-adenosylmethionine binding site [chemical binding]; other site
360115002568	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
360115002569	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115002570	Walker A/P-loop; other site
360115002571	ATP binding site [chemical binding]; other site
360115002572	Q-loop/lid; other site
360115002573	ABC transporter signature motif; other site
360115002574	Walker B; other site
360115002575	D-loop; other site
360115002576	H-loop/switch region; other site
360115002577	maltose O-acetyltransferase; Provisional; Region: PRK10092
360115002578	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
360115002579	trimer interface [polypeptide binding]; other site
360115002580	active site
360115002581	substrate binding site [chemical binding]; other site
360115002582	CoA binding site [chemical binding]; other site
360115002583	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
360115002584	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
360115002585	active site
360115002586	dimer interface [polypeptide binding]; other site
360115002587	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
360115002588	Ligand Binding Site [chemical binding]; other site
360115002589	Molecular Tunnel; other site
360115002590	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
360115002591	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
360115002592	inhibitor-cofactor binding pocket; inhibition site
360115002593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115002594	catalytic residue [active]
360115002595	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
360115002596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
360115002597	NAD(P) binding site [chemical binding]; other site
360115002598	active site
360115002599	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
360115002600	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
360115002601	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
360115002602	putative trimer interface [polypeptide binding]; other site
360115002603	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
360115002604	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
360115002605	putative CoA binding site [chemical binding]; other site
360115002606	putative trimer interface [polypeptide binding]; other site
360115002607	putative active site [active]
360115002608	putative substrate binding site [chemical binding]; other site
360115002609	putative CoA binding site [chemical binding]; other site
360115002610	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
360115002611	Transcriptional regulators [Transcription]; Region: MarR; COG1846
360115002612	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
360115002613	transcriptional activator RfaH; Region: RfaH; TIGR01955
360115002614	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
360115002615	heterodimer interface [polypeptide binding]; other site
360115002616	homodimer interface [polypeptide binding]; other site
360115002617	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
360115002618	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
360115002619	inhibitor-cofactor binding pocket; inhibition site
360115002620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115002621	catalytic residue [active]
360115002622	adenylosuccinate lyase; Provisional; Region: PRK09285
360115002623	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
360115002624	tetramer interface [polypeptide binding]; other site
360115002625	active site
360115002626	malate dehydrogenase; Provisional; Region: PRK13529
360115002627	Malic enzyme, N-terminal domain; Region: malic; pfam00390
360115002628	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
360115002629	NAD(P) binding site [chemical binding]; other site
360115002630	Fic family protein [Function unknown]; Region: COG3177
360115002631	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
360115002632	Fic/DOC family; Region: Fic; pfam02661
360115002633	Leucine rich repeat; Region: LRR_8; pfam13855
360115002634	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
360115002635	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
360115002636	C-terminal domain interface [polypeptide binding]; other site
360115002637	GSH binding site (G-site) [chemical binding]; other site
360115002638	dimer interface [polypeptide binding]; other site
360115002639	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
360115002640	N-terminal domain interface [polypeptide binding]; other site
360115002641	dimer interface [polypeptide binding]; other site
360115002642	substrate binding pocket (H-site) [chemical binding]; other site
360115002643	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
360115002644	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
360115002645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
360115002646	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
360115002647	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
360115002648	cation binding site [ion binding]; other site
360115002649	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
360115002650	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
360115002651	G1 box; other site
360115002652	putative GEF interaction site [polypeptide binding]; other site
360115002653	GTP/Mg2+ binding site [chemical binding]; other site
360115002654	Switch I region; other site
360115002655	G2 box; other site
360115002656	G3 box; other site
360115002657	Switch II region; other site
360115002658	G4 box; other site
360115002659	G5 box; other site
360115002660	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
360115002661	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
360115002662	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
360115002663	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
360115002664	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
360115002665	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
360115002666	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
360115002667	active site
360115002668	HIGH motif; other site
360115002669	nucleotide binding site [chemical binding]; other site
360115002670	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
360115002671	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
360115002672	active site
360115002673	KMSKS motif; other site
360115002674	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
360115002675	tRNA binding surface [nucleotide binding]; other site
360115002676	anticodon binding site; other site
360115002677	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
360115002678	Beta-lactamase; Region: Beta-lactamase; pfam00144
360115002679	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
360115002680	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
360115002681	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
360115002682	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
360115002683	HlyD family secretion protein; Region: HlyD_3; pfam13437
360115002684	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
360115002685	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
360115002686	Coenzyme A binding pocket [chemical binding]; other site
360115002687	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
360115002688	active site
360115002689	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
360115002690	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
360115002691	HlyD family secretion protein; Region: HlyD_3; pfam13437
360115002692	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115002693	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115002694	putative substrate translocation pore; other site
360115002695	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
360115002696	nucleotide binding site/active site [active]
360115002697	HIT family signature motif; other site
360115002698	catalytic residue [active]
360115002699	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
360115002700	homodecamer interface [polypeptide binding]; other site
360115002701	GTP cyclohydrolase I; Provisional; Region: PLN03044
360115002702	active site
360115002703	putative catalytic site residues [active]
360115002704	zinc binding site [ion binding]; other site
360115002705	GTP-CH-I/GFRP interaction surface; other site
360115002706	YcaO-like family; Region: YcaO; pfam02624
360115002707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115002708	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115002709	putative substrate translocation pore; other site
360115002710	PAS fold; Region: PAS_4; pfam08448
360115002711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
360115002712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115002713	dimer interface [polypeptide binding]; other site
360115002714	phosphorylation site [posttranslational modification]
360115002715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115002716	ATP binding site [chemical binding]; other site
360115002717	Mg2+ binding site [ion binding]; other site
360115002718	G-X-G motif; other site
360115002719	Response regulator receiver domain; Region: Response_reg; pfam00072
360115002720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115002721	active site
360115002722	phosphorylation site [posttranslational modification]
360115002723	intermolecular recognition site; other site
360115002724	dimerization interface [polypeptide binding]; other site
360115002725	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
360115002726	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
360115002727	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
360115002728	active site
360115002729	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
360115002730	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
360115002731	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
360115002732	KR domain; Region: KR; pfam08659
360115002733	putative NADP binding site [chemical binding]; other site
360115002734	active site
360115002735	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
360115002736	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
360115002737	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
360115002738	acyl-activating enzyme (AAE) consensus motif; other site
360115002739	AMP binding site [chemical binding]; other site
360115002740	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
360115002741	CoA-transferase family III; Region: CoA_transf_3; pfam02515
360115002742	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115002743	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115002744	response regulator; Provisional; Region: PRK09483
360115002745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115002746	active site
360115002747	phosphorylation site [posttranslational modification]
360115002748	intermolecular recognition site; other site
360115002749	dimerization interface [polypeptide binding]; other site
360115002750	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
360115002751	DNA binding residues [nucleotide binding]
360115002752	dimerization interface [polypeptide binding]; other site
360115002753	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
360115002754	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
360115002755	Walker A/P-loop; other site
360115002756	ATP binding site [chemical binding]; other site
360115002757	Q-loop/lid; other site
360115002758	ABC transporter signature motif; other site
360115002759	Walker B; other site
360115002760	D-loop; other site
360115002761	H-loop/switch region; other site
360115002762	Predicted transcriptional regulators [Transcription]; Region: COG1725
360115002763	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
360115002764	DNA-binding site [nucleotide binding]; DNA binding site
360115002765	PspC domain; Region: PspC; pfam04024
360115002766	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
360115002767	putative dimer interface [polypeptide binding]; other site
360115002768	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
360115002769	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
360115002770	dimer interface [polypeptide binding]; other site
360115002771	Citrate synthase; Region: Citrate_synt; pfam00285
360115002772	active site
360115002773	citrylCoA binding site [chemical binding]; other site
360115002774	oxalacetate/citrate binding site [chemical binding]; other site
360115002775	coenzyme A binding site [chemical binding]; other site
360115002776	catalytic triad [active]
360115002777	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
360115002778	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
360115002779	tetramer interface [polypeptide binding]; other site
360115002780	active site
360115002781	Mg2+/Mn2+ binding site [ion binding]; other site
360115002782	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
360115002783	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
360115002784	catalytic triad [active]
360115002785	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
360115002786	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
360115002787	acyl-activating enzyme (AAE) consensus motif; other site
360115002788	putative AMP binding site [chemical binding]; other site
360115002789	putative active site [active]
360115002790	putative CoA binding site [chemical binding]; other site
360115002791	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115002792	non-specific DNA binding site [nucleotide binding]; other site
360115002793	salt bridge; other site
360115002794	sequence-specific DNA binding site [nucleotide binding]; other site
360115002795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115002796	Response regulator receiver domain; Region: Response_reg; pfam00072
360115002797	active site
360115002798	phosphorylation site [posttranslational modification]
360115002799	intermolecular recognition site; other site
360115002800	dimerization interface [polypeptide binding]; other site
360115002801	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
360115002802	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
360115002803	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
360115002804	RNA binding surface [nucleotide binding]; other site
360115002805	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
360115002806	active site
360115002807	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
360115002808	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
360115002809	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
360115002810	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
360115002811	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
360115002812	protein binding site [polypeptide binding]; other site
360115002813	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
360115002814	protein binding site [polypeptide binding]; other site
360115002815	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
360115002816	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
360115002817	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
360115002818	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
360115002819	hinge; other site
360115002820	active site
360115002821	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
360115002822	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
360115002823	putative active site [active]
360115002824	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
360115002825	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
360115002826	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
360115002827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
360115002828	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
360115002829	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
360115002830	OstA-like protein; Region: OstA; pfam03968
360115002831	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
360115002832	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
360115002833	Walker A/P-loop; other site
360115002834	ATP binding site [chemical binding]; other site
360115002835	Q-loop/lid; other site
360115002836	ABC transporter signature motif; other site
360115002837	Walker B; other site
360115002838	D-loop; other site
360115002839	H-loop/switch region; other site
360115002840	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
360115002841	30S subunit binding site; other site
360115002842	HPr kinase/phosphorylase; Provisional; Region: PRK05428
360115002843	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
360115002844	Hpr binding site; other site
360115002845	active site
360115002846	homohexamer subunit interaction site [polypeptide binding]; other site
360115002847	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
360115002848	dimerization domain swap beta strand [polypeptide binding]; other site
360115002849	regulatory protein interface [polypeptide binding]; other site
360115002850	active site
360115002851	regulatory phosphorylation site [posttranslational modification]; other site
360115002852	peptidase PmbA; Provisional; Region: PRK11040
360115002853	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
360115002854	Found in ATP-dependent protease La (LON); Region: LON; smart00464
360115002855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115002856	Walker A motif; other site
360115002857	ATP binding site [chemical binding]; other site
360115002858	Walker B motif; other site
360115002859	arginine finger; other site
360115002860	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
360115002861	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
360115002862	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
360115002863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115002864	Walker A motif; other site
360115002865	ATP binding site [chemical binding]; other site
360115002866	Walker B motif; other site
360115002867	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
360115002868	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
360115002869	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
360115002870	oligomer interface [polypeptide binding]; other site
360115002871	active site residues [active]
360115002872	trigger factor; Provisional; Region: tig; PRK01490
360115002873	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
360115002874	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
360115002875	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
360115002876	Protein of unknown function (DUF330); Region: DUF330; cl01135
360115002877	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
360115002878	mce related protein; Region: MCE; pfam02470
360115002879	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
360115002880	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115002881	Walker A/P-loop; other site
360115002882	ATP binding site [chemical binding]; other site
360115002883	Q-loop/lid; other site
360115002884	ABC transporter signature motif; other site
360115002885	Walker B; other site
360115002886	D-loop; other site
360115002887	H-loop/switch region; other site
360115002888	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
360115002889	anti sigma factor interaction site; other site
360115002890	regulatory phosphorylation site [posttranslational modification]; other site
360115002891	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
360115002892	Permease; Region: Permease; pfam02405
360115002893	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
360115002894	Uncharacterized conserved protein [Function unknown]; Region: COG0062
360115002895	putative carbohydrate kinase; Provisional; Region: PRK10565
360115002896	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
360115002897	putative substrate binding site [chemical binding]; other site
360115002898	putative ATP binding site [chemical binding]; other site
360115002899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115002900	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115002901	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115002902	ribonuclease R; Region: RNase_R; TIGR02063
360115002903	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
360115002904	RNB domain; Region: RNB; pfam00773
360115002905	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
360115002906	RNA binding site [nucleotide binding]; other site
360115002907	multidrug efflux protein; Reviewed; Region: PRK09579
360115002908	fumarate hydratase; Reviewed; Region: fumC; PRK00485
360115002909	Class II fumarases; Region: Fumarase_classII; cd01362
360115002910	active site
360115002911	tetramer interface [polypeptide binding]; other site
360115002912	Coxiella burnetii protein of unknown function (DUF762); Region: DUF762; pfam05555
360115002913	signal peptidase I; Provisional; Region: PRK10861
360115002914	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
360115002915	Catalytic site [active]
360115002916	Uncharacterized protein family (UPF0146); Region: UPF0146; cl00552
360115002917	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
360115002918	GIY-YIG motif/motif A; other site
360115002919	putative active site [active]
360115002920	putative metal binding site [ion binding]; other site
360115002921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115002922	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115002923	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115002924	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
360115002925	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
360115002926	hexamer interface [polypeptide binding]; other site
360115002927	ligand binding site [chemical binding]; other site
360115002928	putative active site [active]
360115002929	NAD(P) binding site [chemical binding]; other site
360115002930	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
360115002931	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
360115002932	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
360115002933	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
360115002934	Electron transfer flavoprotein domain; Region: ETF; pfam01012
360115002935	Ligand binding site [chemical binding]; other site
360115002936	Dienelactone hydrolase family; Region: DLH; pfam01738
360115002937	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
360115002938	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
360115002939	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
360115002940	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115002941	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
360115002942	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
360115002943	HSP70 interaction site [polypeptide binding]; other site
360115002944	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
360115002945	substrate binding site [polypeptide binding]; other site
360115002946	dimer interface [polypeptide binding]; other site
360115002947	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
360115002948	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
360115002949	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
360115002950	active site
360115002951	Glyco_18 domain; Region: Glyco_18; smart00636
360115002952	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
360115002953	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
360115002954	trimerization site [polypeptide binding]; other site
360115002955	active site
360115002956	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
360115002957	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
360115002958	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
360115002959	catalytic residue [active]
360115002960	OPT oligopeptide transporter protein; Region: OPT; cl14607
360115002961	putative oligopeptide transporter, OPT family; Region: TIGR00733
360115002962	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
360115002963	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
360115002964	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
360115002965	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
360115002966	active site
360115002967	dimerization interface [polypeptide binding]; other site
360115002968	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
360115002969	Sel1-like repeats; Region: SEL1; smart00671
360115002970	Sel1-like repeats; Region: SEL1; smart00671
360115002971	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
360115002972	Sel1-like repeats; Region: SEL1; smart00671
360115002973	Sel1-like repeats; Region: SEL1; smart00671
360115002974	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
360115002975	Sel1-like repeats; Region: SEL1; smart00671
360115002976	Sel1-like repeats; Region: SEL1; smart00671
360115002977	Sel1-like repeats; Region: SEL1; smart00671
360115002978	Sel1-like repeats; Region: SEL1; smart00671
360115002979	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115002980	CAF1 family ribonuclease; Region: CAF1; cl17591
360115002981	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
360115002982	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
360115002983	Protein export membrane protein; Region: SecD_SecF; pfam02355
360115002984	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
360115002985	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
360115002986	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
360115002987	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
360115002988	Mannan-binding protein; Region: MVL; pfam12151
360115002989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115002990	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115002991	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115002992	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
360115002993	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
360115002994	Ligand Binding Site [chemical binding]; other site
360115002995	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
360115002996	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
360115002997	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
360115002998	ATP binding site [chemical binding]; other site
360115002999	putative Mg++ binding site [ion binding]; other site
360115003000	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
360115003001	nucleotide binding region [chemical binding]; other site
360115003002	ATP-binding site [chemical binding]; other site
360115003003	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
360115003004	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
360115003005	Eukaryotic phosphomannomutase; Region: PMM; cl17107
360115003006	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115003007	motif II; other site
360115003008	bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional; Region: PRK13803
360115003009	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
360115003010	active site
360115003011	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
360115003012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115003013	catalytic residue [active]
360115003014	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
360115003015	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
360115003016	substrate binding site [chemical binding]; other site
360115003017	active site
360115003018	catalytic residues [active]
360115003019	heterodimer interface [polypeptide binding]; other site
360115003020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
360115003021	Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222
360115003022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115003023	TPR repeat; Region: TPR_11; pfam13414
360115003024	binding surface
360115003025	TPR motif; other site
360115003026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115003027	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115003028	putative substrate translocation pore; other site
360115003029	Catalytic domain of Protein Kinases; Region: PKc; cd00180
360115003030	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
360115003031	active site
360115003032	ATP binding site [chemical binding]; other site
360115003033	substrate binding site [chemical binding]; other site
360115003034	activation loop (A-loop); other site
360115003035	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
360115003036	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
360115003037	putative dimer interface [polypeptide binding]; other site
360115003038	Domain of unknown function (DUF378); Region: DUF378; pfam04070
360115003039	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
360115003040	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
360115003041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115003042	putative substrate translocation pore; other site
360115003043	Thiamine biosynthesis ATP pyrophosphatase [Coenzyme metabolism]; Region: ThiI; COG0301
360115003044	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
360115003045	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
360115003046	Ligand Binding Site [chemical binding]; other site
360115003047	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
360115003048	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
360115003049	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
360115003050	catalytic residue [active]
360115003051	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
360115003052	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
360115003053	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
360115003054	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
360115003055	putative acyl-acceptor binding pocket; other site
360115003056	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
360115003057	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
360115003058	GIY-YIG motif/motif A; other site
360115003059	active site
360115003060	catalytic site [active]
360115003061	putative DNA binding site [nucleotide binding]; other site
360115003062	metal binding site [ion binding]; metal-binding site
360115003063	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
360115003064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003065	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003066	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003067	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
360115003068	seryl-tRNA synthetase; Provisional; Region: PRK05431
360115003069	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
360115003070	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
360115003071	dimer interface [polypeptide binding]; other site
360115003072	active site
360115003073	motif 1; other site
360115003074	motif 2; other site
360115003075	motif 3; other site
360115003076	recombination factor protein RarA; Reviewed; Region: PRK13342
360115003077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115003078	Walker A motif; other site
360115003079	ATP binding site [chemical binding]; other site
360115003080	Walker B motif; other site
360115003081	arginine finger; other site
360115003082	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
360115003083	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
360115003084	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
360115003085	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
360115003086	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
360115003087	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
360115003088	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
360115003089	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
360115003090	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
360115003091	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
360115003092	rRNA binding site [nucleotide binding]; other site
360115003093	predicted 30S ribosome binding site; other site
360115003094	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
360115003095	Clp amino terminal domain; Region: Clp_N; pfam02861
360115003096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115003097	Walker A motif; other site
360115003098	ATP binding site [chemical binding]; other site
360115003099	Walker B motif; other site
360115003100	arginine finger; other site
360115003101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115003102	Walker A motif; other site
360115003103	ATP binding site [chemical binding]; other site
360115003104	Walker B motif; other site
360115003105	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
360115003106	isocitrate dehydrogenase; Validated; Region: PRK07362
360115003107	isocitrate dehydrogenase; Reviewed; Region: PRK07006
360115003108	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
360115003109	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
360115003110	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
360115003111	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
360115003112	active site
360115003113	FMN binding site [chemical binding]; other site
360115003114	substrate binding site [chemical binding]; other site
360115003115	3Fe-4S cluster binding site [ion binding]; other site
360115003116	Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222
360115003117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115003118	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115003119	putative substrate translocation pore; other site
360115003120	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
360115003121	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
360115003122	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
360115003123	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
360115003124	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
360115003125	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
360115003126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003127	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003128	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003129	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
360115003130	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
360115003131	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
360115003132	ATP binding site [chemical binding]; other site
360115003133	active site
360115003134	substrate binding site [chemical binding]; other site
360115003135	Nucleoporin subcomplex protein binding to Pom34; Region: Nup188; pfam10487
360115003136	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
360115003137	dihydrodipicolinate synthase; Region: dapA; TIGR00674
360115003138	dimer interface [polypeptide binding]; other site
360115003139	active site
360115003140	catalytic residue [active]
360115003141	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
360115003142	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
360115003143	substrate binding site [chemical binding]; other site
360115003144	ATP binding site [chemical binding]; other site
360115003145	RmuC family; Region: RmuC; pfam02646
360115003146	haloalkane dehalogenase; Provisional; Region: PRK03592
360115003147	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
360115003148	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
360115003149	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
360115003150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115003151	active site
360115003152	phosphorylation site [posttranslational modification]
360115003153	intermolecular recognition site; other site
360115003154	dimerization interface [polypeptide binding]; other site
360115003155	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
360115003156	DNA binding site [nucleotide binding]
360115003157	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
360115003158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115003159	dimer interface [polypeptide binding]; other site
360115003160	phosphorylation site [posttranslational modification]
360115003161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115003162	ATP binding site [chemical binding]; other site
360115003163	Mg2+ binding site [ion binding]; other site
360115003164	G-X-G motif; other site
360115003165	probable DNA repair protein; Region: TIGR03623
360115003166	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
360115003167	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
360115003168	Part of AAA domain; Region: AAA_19; pfam13245
360115003169	Family description; Region: UvrD_C_2; pfam13538
360115003170	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
360115003171	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
360115003172	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115003173	AAA domain; Region: AAA_14; pfam13173
360115003174	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
360115003175	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
360115003176	catalytic site [active]
360115003177	putative active site [active]
360115003178	putative substrate binding site [chemical binding]; other site
360115003179	dimer interface [polypeptide binding]; other site
360115003180	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
360115003181	oligomeric interface; other site
360115003182	homodimer interface [polypeptide binding]; other site
360115003183	putative active site [active]
360115003184	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
360115003185	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
360115003186	UGMP family protein; Validated; Region: PRK09604
360115003187	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
360115003188	malate dehydrogenase; Provisional; Region: PRK05442
360115003189	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
360115003190	NAD(P) binding site [chemical binding]; other site
360115003191	dimer interface [polypeptide binding]; other site
360115003192	malate binding site [chemical binding]; other site
360115003193	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
360115003194	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
360115003195	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
360115003196	generic binding surface II; other site
360115003197	generic binding surface I; other site
360115003198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003199	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003200	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003201	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
360115003202	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
360115003203	G1 box; other site
360115003204	GTP/Mg2+ binding site [chemical binding]; other site
360115003205	Switch I region; other site
360115003206	G2 box; other site
360115003207	Switch II region; other site
360115003208	G3 box; other site
360115003209	G4 box; other site
360115003210	G5 box; other site
360115003211	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
360115003212	G1 box; other site
360115003213	GTP/Mg2+ binding site [chemical binding]; other site
360115003214	Switch I region; other site
360115003215	G2 box; other site
360115003216	G3 box; other site
360115003217	Switch II region; other site
360115003218	G4 box; other site
360115003219	G5 box; other site
360115003220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
360115003221	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
360115003222	histidyl-tRNA synthetase; Region: hisS; TIGR00442
360115003223	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
360115003224	dimer interface [polypeptide binding]; other site
360115003225	motif 1; other site
360115003226	active site
360115003227	motif 2; other site
360115003228	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
360115003229	anticodon binding site; other site
360115003230	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
360115003231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115003232	non-specific DNA binding site [nucleotide binding]; other site
360115003233	salt bridge; other site
360115003234	sequence-specific DNA binding site [nucleotide binding]; other site
360115003235	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
360115003236	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115003237	FeS/SAM binding site; other site
360115003238	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115003239	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
360115003240	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
360115003241	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
360115003242	substrate binding pocket [chemical binding]; other site
360115003243	chain length determination region; other site
360115003244	substrate-Mg2+ binding site; other site
360115003245	catalytic residues [active]
360115003246	aspartate-rich region 1; other site
360115003247	active site lid residues [active]
360115003248	aspartate-rich region 2; other site
360115003249	SnoaL-like domain; Region: SnoaL_2; pfam12680
360115003250	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
360115003251	active site
360115003252	multimer interface [polypeptide binding]; other site
360115003253	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
360115003254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003255	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003256	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003257	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
360115003258	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
360115003259	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
360115003260	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
360115003261	Protein of unknown function (DUF493); Region: DUF493; pfam04359
360115003262	lipoate-protein ligase B; Provisional; Region: PRK14342
360115003263	lipoyl synthase; Provisional; Region: PRK05481
360115003264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115003265	FeS/SAM binding site; other site
360115003266	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
360115003267	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
360115003268	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
360115003269	active site
360115003270	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
360115003271	LssY C-terminus; Region: LssY_C; pfam14067
360115003272	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
360115003273	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
360115003274	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003275	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003276	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003277	6-phosphofructokinase; Provisional; Region: PRK14072
360115003278	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
360115003279	active site
360115003280	ADP/pyrophosphate binding site [chemical binding]; other site
360115003281	dimerization interface [polypeptide binding]; other site
360115003282	allosteric effector site; other site
360115003283	fructose-1,6-bisphosphate binding site; other site
360115003284	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
360115003285	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
360115003286	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
360115003287	metal binding site [ion binding]; metal-binding site
360115003288	substrate binding pocket [chemical binding]; other site
360115003289	short chain dehydrogenase; Provisional; Region: PRK07890
360115003290	classical (c) SDRs; Region: SDR_c; cd05233
360115003291	NAD(P) binding site [chemical binding]; other site
360115003292	active site
360115003293	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
360115003294	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
360115003295	active site
360115003296	intersubunit interface [polypeptide binding]; other site
360115003297	catalytic residue [active]
360115003298	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
360115003299	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
360115003300	putative catalytic residue [active]
360115003301	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
360115003302	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
360115003303	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
360115003304	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
360115003305	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
360115003306	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
360115003307	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
360115003308	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
360115003309	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
360115003310	ATP-grasp domain; Region: ATP-grasp_4; cl17255
360115003311	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
360115003312	IMP binding site; other site
360115003313	dimer interface [polypeptide binding]; other site
360115003314	interdomain contacts; other site
360115003315	partial ornithine binding site; other site
360115003316	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
360115003317	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
360115003318	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
360115003319	catalytic site [active]
360115003320	subunit interface [polypeptide binding]; other site
360115003321	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115003322	AAA domain; Region: AAA_14; pfam13173
360115003323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115003324	Major Facilitator Superfamily; Region: MFS_1; pfam07690
360115003325	putative substrate translocation pore; other site
360115003326	AAA domain; Region: AAA_14; pfam13173
360115003327	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
360115003328	chaperone protein DnaJ; Provisional; Region: PRK10767
360115003329	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
360115003330	HSP70 interaction site [polypeptide binding]; other site
360115003331	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
360115003332	Zn binding sites [ion binding]; other site
360115003333	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
360115003334	dimer interface [polypeptide binding]; other site
360115003335	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
360115003336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
360115003337	nucleotide binding site [chemical binding]; other site
360115003338	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
360115003339	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
360115003340	carboxyltransferase (CT) interaction site; other site
360115003341	biotinylation site [posttranslational modification]; other site
360115003342	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115003343	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
360115003344	GrpE; Region: GrpE; pfam01025
360115003345	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
360115003346	dimer interface [polypeptide binding]; other site
360115003347	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
360115003348	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
360115003349	oligomeric interface; other site
360115003350	putative active site [active]
360115003351	homodimer interface [polypeptide binding]; other site
360115003352	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
360115003353	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
360115003354	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
360115003355	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
360115003356	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
360115003357	Walker A/P-loop; other site
360115003358	ATP binding site [chemical binding]; other site
360115003359	Q-loop/lid; other site
360115003360	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
360115003361	ABC transporter signature motif; other site
360115003362	Walker B; other site
360115003363	D-loop; other site
360115003364	H-loop/switch region; other site
360115003365	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
360115003366	metal binding site 2 [ion binding]; metal-binding site
360115003367	putative DNA binding helix; other site
360115003368	metal binding site 1 [ion binding]; metal-binding site
360115003369	dimer interface [polypeptide binding]; other site
360115003370	structural Zn2+ binding site [ion binding]; other site
360115003371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
360115003372	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
360115003373	putative coenzyme Q binding site [chemical binding]; other site
360115003374	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
360115003375	SmpB-tmRNA interface; other site
360115003376	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
360115003377	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
360115003378	methionine sulfoxide reductase A; Provisional; Region: PRK14054
360115003379	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
360115003380	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
360115003381	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
360115003382	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
360115003383	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
360115003384	DNA binding residues [nucleotide binding]
360115003385	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
360115003386	IHF dimer interface [polypeptide binding]; other site
360115003387	IHF - DNA interface [nucleotide binding]; other site
360115003388	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
360115003389	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
360115003390	putative tRNA-binding site [nucleotide binding]; other site
360115003391	B3/4 domain; Region: B3_4; pfam03483
360115003392	tRNA synthetase B5 domain; Region: B5; smart00874
360115003393	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
360115003394	dimer interface [polypeptide binding]; other site
360115003395	motif 1; other site
360115003396	motif 3; other site
360115003397	motif 2; other site
360115003398	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
360115003399	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
360115003400	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
360115003401	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
360115003402	dimer interface [polypeptide binding]; other site
360115003403	motif 1; other site
360115003404	active site
360115003405	motif 2; other site
360115003406	motif 3; other site
360115003407	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
360115003408	23S rRNA binding site [nucleotide binding]; other site
360115003409	L21 binding site [polypeptide binding]; other site
360115003410	L13 binding site [polypeptide binding]; other site
360115003411	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
360115003412	translation initiation factor IF-3; Region: infC; TIGR00168
360115003413	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
360115003414	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
360115003415	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
360115003416	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
360115003417	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
360115003418	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
360115003419	active site
360115003420	dimer interface [polypeptide binding]; other site
360115003421	motif 1; other site
360115003422	motif 2; other site
360115003423	motif 3; other site
360115003424	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
360115003425	anticodon binding site; other site
360115003426	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
360115003427	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115003428	FeS/SAM binding site; other site
360115003429	FOG: CBS domain [General function prediction only]; Region: COG0517
360115003430	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
360115003431	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
360115003432	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
360115003433	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
360115003434	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
360115003435	putative active site [active]
360115003436	putative PHP Thumb interface [polypeptide binding]; other site
360115003437	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
360115003438	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
360115003439	generic binding surface II; other site
360115003440	generic binding surface I; other site
360115003441	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
360115003442	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
360115003443	ATP-grasp domain; Region: ATP-grasp_4; cl17255
360115003444	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
360115003445	RNA/DNA hybrid binding site [nucleotide binding]; other site
360115003446	active site
360115003447	GMP synthase; Reviewed; Region: guaA; PRK00074
360115003448	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
360115003449	AMP/PPi binding site [chemical binding]; other site
360115003450	candidate oxyanion hole; other site
360115003451	catalytic triad [active]
360115003452	potential glutamine specificity residues [chemical binding]; other site
360115003453	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
360115003454	ATP Binding subdomain [chemical binding]; other site
360115003455	Ligand Binding sites [chemical binding]; other site
360115003456	Dimerization subdomain; other site
360115003457	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
360115003458	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
360115003459	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
360115003460	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
360115003461	active site
360115003462	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
360115003463	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
360115003464	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
360115003465	active site
360115003466	substrate binding site [chemical binding]; other site
360115003467	metal binding site [ion binding]; metal-binding site
360115003468	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
360115003469	dihydropteroate synthase; Region: DHPS; TIGR01496
360115003470	substrate binding pocket [chemical binding]; other site
360115003471	dimer interface [polypeptide binding]; other site
360115003472	inhibitor binding site; inhibition site
360115003473	FtsH Extracellular; Region: FtsH_ext; pfam06480
360115003474	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
360115003475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115003476	Walker A motif; other site
360115003477	ATP binding site [chemical binding]; other site
360115003478	Walker B motif; other site
360115003479	arginine finger; other site
360115003480	Peptidase family M41; Region: Peptidase_M41; pfam01434
360115003481	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
360115003482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115003483	S-adenosylmethionine binding site [chemical binding]; other site
360115003484	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
360115003485	FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997
360115003486	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
360115003487	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
360115003488	trimerization site [polypeptide binding]; other site
360115003489	active site
360115003490	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
360115003491	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
360115003492	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
360115003493	catalytic residue [active]
360115003494	FeS assembly protein SufD; Region: sufD; TIGR01981
360115003495	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
360115003496	FeS assembly ATPase SufC; Region: sufC; TIGR01978
360115003497	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
360115003498	Walker A/P-loop; other site
360115003499	ATP binding site [chemical binding]; other site
360115003500	Q-loop/lid; other site
360115003501	ABC transporter signature motif; other site
360115003502	Walker B; other site
360115003503	D-loop; other site
360115003504	H-loop/switch region; other site
360115003505	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
360115003506	putative ABC transporter; Region: ycf24; CHL00085
360115003507	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
360115003508	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
360115003509	putative DNA binding site [nucleotide binding]; other site
360115003510	putative Zn2+ binding site [ion binding]; other site
360115003511	Transcriptional regulator; Region: Rrf2; cl17282
360115003512	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
360115003513	Cation efflux family; Region: Cation_efflux; pfam01545
360115003514	exonuclease I; Provisional; Region: sbcB; PRK11779
360115003515	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
360115003516	active site
360115003517	catalytic site [active]
360115003518	substrate binding site [chemical binding]; other site
360115003519	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
360115003520	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003521	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003522	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003523	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003524	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003525	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003526	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003527	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003528	Protein of unknown function (DUF1601); Region: DUF1601; pfam07671
360115003529	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
360115003530	Glycoprotease family; Region: Peptidase_M22; pfam00814
360115003531	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003532	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003533	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003534	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
360115003535	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
360115003536	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
360115003537	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
360115003538	nucleoside/Zn binding site; other site
360115003539	dimer interface [polypeptide binding]; other site
360115003540	catalytic motif [active]
360115003541	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
360115003542	HD domain; Region: HD_4; pfam13328
360115003543	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
360115003544	synthetase active site [active]
360115003545	NTP binding site [chemical binding]; other site
360115003546	metal binding site [ion binding]; metal-binding site
360115003547	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
360115003548	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
360115003549	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
360115003550	zinc metallopeptidase RseP; Provisional; Region: PRK10779
360115003551	active site
360115003552	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
360115003553	protein binding site [polypeptide binding]; other site
360115003554	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
360115003555	protein binding site [polypeptide binding]; other site
360115003556	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
360115003557	putative substrate binding region [chemical binding]; other site
360115003558	Protein of unknown function (DUF812); Region: DUF812; pfam05667
360115003559	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
360115003560	active site
360115003561	substrate binding site [chemical binding]; other site
360115003562	activation loop (A-loop); other site
360115003563	Predicted membrane protein [Function unknown]; Region: COG2259
360115003564	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
360115003565	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
360115003566	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
360115003567	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
360115003568	catalytic residue [active]
360115003569	putative FPP diphosphate  binding site; other site
360115003570	putative FPP binding hydrophobic cleft; other site
360115003571	dimer interface [polypeptide binding]; other site
360115003572	putative IPP diphosphate binding site; other site
360115003573	ribosome recycling factor; Reviewed; Region: frr; PRK00083
360115003574	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
360115003575	hinge region; other site
360115003576	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
360115003577	putative nucleotide binding site [chemical binding]; other site
360115003578	uridine monophosphate binding site [chemical binding]; other site
360115003579	homohexameric interface [polypeptide binding]; other site
360115003580	elongation factor Ts; Provisional; Region: tsf; PRK09377
360115003581	UBA/TS-N domain; Region: UBA; pfam00627
360115003582	Elongation factor TS; Region: EF_TS; pfam00889
360115003583	Elongation factor TS; Region: EF_TS; pfam00889
360115003584	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
360115003585	rRNA interaction site [nucleotide binding]; other site
360115003586	S8 interaction site; other site
360115003587	putative laminin-1 binding site; other site
360115003588	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
360115003589	active site
360115003590	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
360115003591	Condensation domain; Region: Condensation; pfam00668
360115003592	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115003593	GtrA-like protein; Region: GtrA; pfam04138
360115003594	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
360115003595	CoA binding domain; Region: CoA_binding; pfam02629
360115003596	CoA-ligase; Region: Ligase_CoA; pfam00549
360115003597	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
360115003598	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
360115003599	CoA-ligase; Region: Ligase_CoA; pfam00549
360115003600	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
360115003601	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
360115003602	E3 interaction surface; other site
360115003603	lipoyl attachment site [posttranslational modification]; other site
360115003604	e3 binding domain; Region: E3_binding; pfam02817
360115003605	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
360115003606	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
360115003607	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
360115003608	TPP-binding site [chemical binding]; other site
360115003609	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
360115003610	dimer interface [polypeptide binding]; other site
360115003611	PYR/PP interface [polypeptide binding]; other site
360115003612	TPP binding site [chemical binding]; other site
360115003613	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
360115003614	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
360115003615	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
360115003616	L-aspartate oxidase; Provisional; Region: PRK06175
360115003617	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
360115003618	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
360115003619	SdhC subunit interface [polypeptide binding]; other site
360115003620	proximal heme binding site [chemical binding]; other site
360115003621	cardiolipin binding site; other site
360115003622	Iron-sulfur protein interface; other site
360115003623	proximal quinone binding site [chemical binding]; other site
360115003624	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
360115003625	Iron-sulfur protein interface; other site
360115003626	proximal quinone binding site [chemical binding]; other site
360115003627	SdhD (CybS) interface [polypeptide binding]; other site
360115003628	proximal heme binding site [chemical binding]; other site
360115003629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003630	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003631	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003632	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
360115003633	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
360115003634	dimer interface [polypeptide binding]; other site
360115003635	active site
360115003636	citrylCoA binding site [chemical binding]; other site
360115003637	NADH binding [chemical binding]; other site
360115003638	cationic pore residues; other site
360115003639	oxalacetate/citrate binding site [chemical binding]; other site
360115003640	coenzyme A binding site [chemical binding]; other site
360115003641	catalytic triad [active]
360115003642	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
360115003643	thiamine monophosphate kinase; Provisional; Region: PRK05731
360115003644	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
360115003645	ATP binding site [chemical binding]; other site
360115003646	dimerization interface [polypeptide binding]; other site
360115003647	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115003648	non-specific DNA binding site [nucleotide binding]; other site
360115003649	salt bridge; other site
360115003650	sequence-specific DNA binding site [nucleotide binding]; other site
360115003651	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
360115003652	Catalytic site [active]
360115003653	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
360115003654	putative RNA binding site [nucleotide binding]; other site
360115003655	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
360115003656	ATP cone domain; Region: ATP-cone; pfam03477
360115003657	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
360115003658	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
360115003659	dimer interface [polypeptide binding]; other site
360115003660	active site
360115003661	glycine-pyridoxal phosphate binding site [chemical binding]; other site
360115003662	folate binding site [chemical binding]; other site
360115003663	DNA repair protein RadA; Provisional; Region: PRK11823
360115003664	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
360115003665	Walker A motif/ATP binding site; other site
360115003666	ATP binding site [chemical binding]; other site
360115003667	Walker B motif; other site
360115003668	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
360115003669	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
360115003670	dimer interface [polypeptide binding]; other site
360115003671	active site
360115003672	Schiff base residues; other site
360115003673	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
360115003674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003675	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003676	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003677	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003678	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003679	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003680	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
360115003681	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
360115003682	RNA binding site [nucleotide binding]; other site
360115003683	active site
360115003684	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
360115003685	ribosome-binding factor A; Provisional; Region: PRK13817
360115003686	translation initiation factor IF-2; Validated; Region: infB; PRK05306
360115003687	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
360115003688	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
360115003689	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
360115003690	G1 box; other site
360115003691	putative GEF interaction site [polypeptide binding]; other site
360115003692	GTP/Mg2+ binding site [chemical binding]; other site
360115003693	Switch I region; other site
360115003694	G2 box; other site
360115003695	G3 box; other site
360115003696	Switch II region; other site
360115003697	G4 box; other site
360115003698	G5 box; other site
360115003699	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
360115003700	Translation-initiation factor 2; Region: IF-2; pfam11987
360115003701	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
360115003702	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
360115003703	NusA N-terminal domain; Region: NusA_N; pfam08529
360115003704	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
360115003705	RNA binding site [nucleotide binding]; other site
360115003706	homodimer interface [polypeptide binding]; other site
360115003707	NusA-like KH domain; Region: KH_5; pfam13184
360115003708	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
360115003709	G-X-X-G motif; other site
360115003710	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
360115003711	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
360115003712	ribosome maturation protein RimP; Reviewed; Region: PRK00092
360115003713	Sm and related proteins; Region: Sm_like; cl00259
360115003714	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
360115003715	putative oligomer interface [polypeptide binding]; other site
360115003716	putative RNA binding site [nucleotide binding]; other site
360115003717	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
360115003718	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
360115003719	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
360115003720	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
360115003721	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
360115003722	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
360115003723	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
360115003724	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
360115003725	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
360115003726	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
360115003727	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
360115003728	4Fe-4S binding domain; Region: Fer4; pfam00037
360115003729	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
360115003730	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
360115003731	NADH dehydrogenase subunit G; Validated; Region: PRK09129
360115003732	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
360115003733	catalytic loop [active]
360115003734	iron binding site [ion binding]; other site
360115003735	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
360115003736	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
360115003737	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
360115003738	molybdopterin cofactor binding site; other site
360115003739	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
360115003740	SLBB domain; Region: SLBB; pfam10531
360115003741	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
360115003742	NADH dehydrogenase subunit E; Validated; Region: PRK07539
360115003743	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
360115003744	putative dimer interface [polypeptide binding]; other site
360115003745	[2Fe-2S] cluster binding site [ion binding]; other site
360115003746	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
360115003747	NADH dehydrogenase subunit D; Validated; Region: PRK06075
360115003748	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
360115003749	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
360115003750	NADH dehydrogenase subunit B; Validated; Region: PRK06411
360115003751	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
360115003752	Preprotein translocase SecG subunit; Region: SecG; pfam03840
360115003753	triosephosphate isomerase; Provisional; Region: PRK14567
360115003754	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
360115003755	substrate binding site [chemical binding]; other site
360115003756	dimer interface [polypeptide binding]; other site
360115003757	catalytic triad [active]
360115003758	SurA N-terminal domain; Region: SurA_N_3; cl07813
360115003759	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
360115003760	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115003761	AAA domain; Region: AAA_14; pfam13173
360115003762	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
360115003763	IHF dimer interface [polypeptide binding]; other site
360115003764	IHF - DNA interface [nucleotide binding]; other site
360115003765	EVE domain; Region: EVE; cl00728
360115003766	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
360115003767	protease TldD; Provisional; Region: tldD; PRK10735
360115003768	Protein of unknown function; Region: DUF3971; pfam13116
360115003769	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
360115003770	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
360115003771	rod shape-determining protein MreC; Provisional; Region: PRK13922
360115003772	rod shape-determining protein MreC; Region: MreC; pfam04085
360115003773	rod shape-determining protein MreB; Provisional; Region: PRK13927
360115003774	MreB and similar proteins; Region: MreB_like; cd10225
360115003775	nucleotide binding site [chemical binding]; other site
360115003776	Mg binding site [ion binding]; other site
360115003777	putative protofilament interaction site [polypeptide binding]; other site
360115003778	RodZ interaction site [polypeptide binding]; other site
360115003779	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
360115003780	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
360115003781	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
360115003782	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
360115003783	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
360115003784	GatB domain; Region: GatB_Yqey; smart00845
360115003785	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003786	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003787	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003788	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
360115003789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
360115003790	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
360115003791	dimerization interface [polypeptide binding]; other site
360115003792	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
360115003793	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
360115003794	dimer interface [polypeptide binding]; other site
360115003795	decamer (pentamer of dimers) interface [polypeptide binding]; other site
360115003796	catalytic triad [active]
360115003797	peroxidatic and resolving cysteines [active]
360115003798	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
360115003799	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
360115003800	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
360115003801	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
360115003802	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
360115003803	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
360115003804	dimer interface [polypeptide binding]; other site
360115003805	active site residues [active]
360115003806	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
360115003807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115003808	D-galactonate transporter; Region: 2A0114; TIGR00893
360115003809	putative substrate translocation pore; other site
360115003810	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
360115003811	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
360115003812	active site
360115003813	HIGH motif; other site
360115003814	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
360115003815	KMSKS motif; other site
360115003816	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
360115003817	tRNA binding surface [nucleotide binding]; other site
360115003818	anticodon binding site; other site
360115003819	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
360115003820	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
360115003821	HIGH motif; other site
360115003822	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
360115003823	active site
360115003824	KMSKS motif; other site
360115003825	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
360115003826	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
360115003827	putative active site [active]
360115003828	putative metal binding site [ion binding]; other site
360115003829	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
360115003830	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115003831	sequence-specific DNA binding site [nucleotide binding]; other site
360115003832	salt bridge; other site
360115003833	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
360115003834	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
360115003835	Transposase [DNA replication, recombination, and repair]; Region: COG5433
360115003836	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
360115003837	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
360115003838	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541
360115003839	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003840	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003841	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003842	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
360115003843	active site
360115003844	hydrophilic channel; other site
360115003845	dimerization interface [polypeptide binding]; other site
360115003846	catalytic residues [active]
360115003847	active site lid [active]
360115003848	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
360115003849	Recombination protein O N terminal; Region: RecO_N; pfam11967
360115003850	Recombination protein O C terminal; Region: RecO_C; pfam02565
360115003851	GTPase Era; Reviewed; Region: era; PRK00089
360115003852	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
360115003853	G1 box; other site
360115003854	GTP/Mg2+ binding site [chemical binding]; other site
360115003855	Switch I region; other site
360115003856	G2 box; other site
360115003857	Switch II region; other site
360115003858	G3 box; other site
360115003859	G4 box; other site
360115003860	G5 box; other site
360115003861	KH domain; Region: KH_2; pfam07650
360115003862	ribonuclease III; Reviewed; Region: rnc; PRK00102
360115003863	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
360115003864	dimerization interface [polypeptide binding]; other site
360115003865	active site
360115003866	metal binding site [ion binding]; metal-binding site
360115003867	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
360115003868	dsRNA binding site [nucleotide binding]; other site
360115003869	signal peptidase I; Provisional; Region: PRK10861
360115003870	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
360115003871	Catalytic site [active]
360115003872	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
360115003873	GTP-binding protein LepA; Provisional; Region: PRK05433
360115003874	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
360115003875	G1 box; other site
360115003876	putative GEF interaction site [polypeptide binding]; other site
360115003877	GTP/Mg2+ binding site [chemical binding]; other site
360115003878	Switch I region; other site
360115003879	G2 box; other site
360115003880	G3 box; other site
360115003881	Switch II region; other site
360115003882	G4 box; other site
360115003883	G5 box; other site
360115003884	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
360115003885	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
360115003886	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
360115003887	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
360115003888	active site
360115003889	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
360115003890	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
360115003891	metal-binding site [ion binding]
360115003892	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
360115003893	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115003894	motif II; other site
360115003895	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115003896	AAA domain; Region: AAA_14; pfam13173
360115003897	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
360115003898	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
360115003899	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
360115003900	Ligand Binding Site [chemical binding]; other site
360115003901	TilS substrate binding domain; Region: TilS; pfam09179
360115003902	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
360115003903	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
360115003904	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
360115003905	ZIP Zinc transporter; Region: Zip; pfam02535
360115003906	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
360115003907	rhodanese superfamily protein; Provisional; Region: PRK05320
360115003908	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
360115003909	active site residue [active]
360115003910	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
360115003911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
360115003912	NAD(P) binding site [chemical binding]; other site
360115003913	active site
360115003914	Transposase [DNA replication, recombination, and repair]; Region: COG5421
360115003915	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
360115003916	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
360115003917	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
360115003918	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
360115003919	preprotein translocase subunit SecB; Validated; Region: PRK05751
360115003920	SecA binding site; other site
360115003921	Preprotein binding site; other site
360115003922	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
360115003923	GSH binding site [chemical binding]; other site
360115003924	catalytic residues [active]
360115003925	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
360115003926	active site residue [active]
360115003927	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
360115003928	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
360115003929	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
360115003930	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003931	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003932	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003933	phosphoglyceromutase; Provisional; Region: PRK05434
360115003934	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
360115003935	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
360115003936	Peptidase family M23; Region: Peptidase_M23; pfam01551
360115003937	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
360115003938	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
360115003939	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
360115003940	protein binding site [polypeptide binding]; other site
360115003941	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
360115003942	Catalytic dyad [active]
360115003943	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
360115003944	aromatic amino acid transport protein; Region: araaP; TIGR00837
360115003945	Insulin-induced protein (INSIG); Region: INSIG; pfam07281
360115003946	thymidylate synthase; Reviewed; Region: thyA; PRK01827
360115003947	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
360115003948	dimerization interface [polypeptide binding]; other site
360115003949	active site
360115003950	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
360115003951	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
360115003952	GAF domain; Region: GAF; pfam01590
360115003953	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
360115003954	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
360115003955	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
360115003956	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
360115003957	putative active site [active]
360115003958	Ap4A binding site [chemical binding]; other site
360115003959	nudix motif; other site
360115003960	putative metal binding site [ion binding]; other site
360115003961	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
360115003962	ATP cone domain; Region: ATP-cone; pfam03477
360115003963	Class I ribonucleotide reductase; Region: RNR_I; cd01679
360115003964	active site
360115003965	dimer interface [polypeptide binding]; other site
360115003966	catalytic residues [active]
360115003967	effector binding site; other site
360115003968	R2 peptide binding site; other site
360115003969	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
360115003970	dimer interface [polypeptide binding]; other site
360115003971	putative radical transfer pathway; other site
360115003972	diiron center [ion binding]; other site
360115003973	tyrosyl radical; other site
360115003974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115003975	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115003976	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115003977	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
360115003978	Transposase [DNA replication, recombination, and repair]; Region: COG5433
360115003979	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
360115003980	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
360115003981	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
360115003982	Uncharacterized conserved protein [Function unknown]; Region: COG2928
360115003983	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
360115003984	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
360115003985	dimer interface [polypeptide binding]; other site
360115003986	anticodon binding site; other site
360115003987	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
360115003988	homodimer interface [polypeptide binding]; other site
360115003989	motif 1; other site
360115003990	active site
360115003991	motif 2; other site
360115003992	GAD domain; Region: GAD; pfam02938
360115003993	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
360115003994	active site
360115003995	motif 3; other site
360115003996	hypothetical protein; Validated; Region: PRK00110
360115003997	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
360115003998	active site
360115003999	putative DNA-binding cleft [nucleotide binding]; other site
360115004000	dimer interface [polypeptide binding]; other site
360115004001	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
360115004002	RuvA N terminal domain; Region: RuvA_N; pfam01330
360115004003	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
360115004004	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
360115004005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115004006	Walker A motif; other site
360115004007	ATP binding site [chemical binding]; other site
360115004008	Walker B motif; other site
360115004009	arginine finger; other site
360115004010	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
360115004011	TolQ protein; Region: tolQ; TIGR02796
360115004012	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
360115004013	TolR protein; Region: tolR; TIGR02801
360115004014	L,D-transpeptidase; Provisional; Region: PRK10260
360115004015	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
360115004016	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
360115004017	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
360115004018	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
360115004019	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
360115004020	Predicted ATPase [General function prediction only]; Region: COG1485
360115004021	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
360115004022	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
360115004023	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
360115004024	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
360115004025	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
360115004026	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
360115004027	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
360115004028	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
360115004029	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
360115004030	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
360115004031	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004032	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004033	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004034	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
360115004035	Yqey-like protein; Region: YqeY; pfam09424
360115004036	DNA primase; Validated; Region: dnaG; PRK05667
360115004037	CHC2 zinc finger; Region: zf-CHC2; pfam01807
360115004038	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
360115004039	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
360115004040	active site
360115004041	metal binding site [ion binding]; metal-binding site
360115004042	interdomain interaction site; other site
360115004043	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
360115004044	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
360115004045	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
360115004046	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
360115004047	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
360115004048	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
360115004049	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
360115004050	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
360115004051	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
360115004052	DNA binding residues [nucleotide binding]
360115004053	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
360115004054	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
360115004055	RimK-like ATP-grasp domain; Region: RimK; pfam08443
360115004056	Predicted deacylase [General function prediction only]; Region: COG3608
360115004057	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
360115004058	putative active site [active]
360115004059	Zn binding site [ion binding]; other site
360115004060	Ankyrin repeat; Region: Ank; pfam00023
360115004061	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004062	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004063	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004064	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004065	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004066	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004067	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004068	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004069	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004070	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
360115004071	AAA-like domain; Region: AAA_10; pfam12846
360115004072	HNH nucleases; Region: HNHc; smart00507
360115004073	hypothetical protein; Provisional; Region: PRK11637
360115004074	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
360115004075	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
360115004076	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
360115004077	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
360115004078	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
360115004079	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
360115004080	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
360115004081	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
360115004082	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
360115004083	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
360115004084	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
360115004085	ligand binding site [chemical binding]; other site
360115004086	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115004087	Walker A motif; other site
360115004088	ATP binding site [chemical binding]; other site
360115004089	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
360115004090	Dot/Icm secretion system protein IcmQ; Region: dot_icm_IcmQ; TIGR02527
360115004091	AAA domain; Region: AAA_22; pfam13401
360115004092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115004093	Walker A motif; other site
360115004094	ATP binding site [chemical binding]; other site
360115004095	Walker B motif; other site
360115004096	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
360115004097	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
360115004098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004099	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004100	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004101	Protein of unknown function (DUF3773); Region: DUF3773; pfam12608
360115004102	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
360115004103	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
360115004104	Walker A motif; other site
360115004105	ATP binding site [chemical binding]; other site
360115004106	Walker B motif; other site
360115004107	BCCT family transporter; Region: BCCT; cl00569
360115004108	BCCT family transporter; Region: BCCT; cl00569
360115004109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004110	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004111	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004112	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
360115004113	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
360115004114	putative ribose interaction site [chemical binding]; other site
360115004115	putative ADP binding site [chemical binding]; other site
360115004116	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
360115004117	active site
360115004118	nucleotide binding site [chemical binding]; other site
360115004119	HIGH motif; other site
360115004120	KMSKS motif; other site
360115004121	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004122	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004123	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004124	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
360115004125	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004126	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004127	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004128	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
360115004129	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
360115004130	putative metal binding site; other site
360115004131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
360115004132	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
360115004133	O-Antigen ligase; Region: Wzy_C; pfam04932
360115004134	Uncharacterized conserved protein [Function unknown]; Region: COG5495
360115004135	Rossmann-like domain; Region: Rossmann-like; pfam10727
360115004136	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
360115004137	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
360115004138	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
360115004139	putative active site [active]
360115004140	Zinc-finger domain; Region: zf-CHCC; cl01821
360115004141	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_27; cd04640
360115004142	FOG: CBS domain [General function prediction only]; Region: COG0517
360115004143	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
360115004144	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
360115004145	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
360115004146	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
360115004147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
360115004148	DNA binding residues [nucleotide binding]
360115004149	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
360115004150	Peptidase family M23; Region: Peptidase_M23; pfam01551
360115004151	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
360115004152	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
360115004153	Septum formation initiator; Region: DivIC; cl17659
360115004154	enolase; Provisional; Region: eno; PRK00077
360115004155	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
360115004156	dimer interface [polypeptide binding]; other site
360115004157	metal binding site [ion binding]; metal-binding site
360115004158	substrate binding pocket [chemical binding]; other site
360115004159	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
360115004160	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
360115004161	Hemerythrin-like domain; Region: Hr-like; cd12108
360115004162	Fe binding site [ion binding]; other site
360115004163	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
360115004164	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
360115004165	CTP synthetase; Validated; Region: pyrG; PRK05380
360115004166	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
360115004167	Catalytic site [active]
360115004168	active site
360115004169	UTP binding site [chemical binding]; other site
360115004170	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
360115004171	active site
360115004172	putative oxyanion hole; other site
360115004173	catalytic triad [active]
360115004174	V-type ATP synthase subunit I; Validated; Region: PRK05771
360115004175	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
360115004176	trimer interface [polypeptide binding]; other site
360115004177	active site
360115004178	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
360115004179	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
360115004180	Walker A motif; other site
360115004181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
360115004182	non-specific DNA binding site [nucleotide binding]; other site
360115004183	salt bridge; other site
360115004184	sequence-specific DNA binding site [nucleotide binding]; other site
360115004185	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
360115004186	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
360115004187	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
360115004188	active site
360115004189	HIGH motif; other site
360115004190	KMSKS motif; other site
360115004191	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
360115004192	tRNA binding surface [nucleotide binding]; other site
360115004193	anticodon binding site; other site
360115004194	ferredoxin; Provisional; Region: PRK08764
360115004195	Putative Fe-S cluster; Region: FeS; pfam04060
360115004196	4Fe-4S binding domain; Region: Fer4; pfam00037
360115004197	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
360115004198	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
360115004199	minor groove reading motif; other site
360115004200	helix-hairpin-helix signature motif; other site
360115004201	substrate binding pocket [chemical binding]; other site
360115004202	active site
360115004203	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
360115004204	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115004205	AAA domain; Region: AAA_14; pfam13173
360115004206	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
360115004207	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
360115004208	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
360115004209	active site
360115004210	substrate binding pocket [chemical binding]; other site
360115004211	dimer interface [polypeptide binding]; other site
360115004212	peroxidase; Provisional; Region: PRK15000
360115004213	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
360115004214	dimer interface [polypeptide binding]; other site
360115004215	decamer (pentamer of dimers) interface [polypeptide binding]; other site
360115004216	catalytic triad [active]
360115004217	peroxidatic and resolving cysteines [active]
360115004218	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
360115004219	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
360115004220	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
360115004221	dihydrodipicolinate reductase; Provisional; Region: PRK00048
360115004222	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
360115004223	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
360115004224	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
360115004225	GIY-YIG motif/motif A; other site
360115004226	putative active site [active]
360115004227	putative metal binding site [ion binding]; other site
360115004228	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
360115004229	tetramer interface [polypeptide binding]; other site
360115004230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115004231	catalytic residue [active]
360115004232	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
360115004233	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
360115004234	tetramer interface [polypeptide binding]; other site
360115004235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115004236	catalytic residue [active]
360115004237	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
360115004238	lipoyl attachment site [posttranslational modification]; other site
360115004239	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
360115004240	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
360115004241	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
360115004242	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
360115004243	ring oligomerisation interface [polypeptide binding]; other site
360115004244	ATP/Mg binding site [chemical binding]; other site
360115004245	stacking interactions; other site
360115004246	hinge regions; other site
360115004247	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
360115004248	oligomerisation interface [polypeptide binding]; other site
360115004249	mobile loop; other site
360115004250	roof hairpin; other site
360115004251	aconitate hydratase; Validated; Region: PRK09277
360115004252	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
360115004253	substrate binding site [chemical binding]; other site
360115004254	ligand binding site [chemical binding]; other site
360115004255	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
360115004256	substrate binding site [chemical binding]; other site
360115004257	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
360115004258	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
360115004259	acyl-activating enzyme (AAE) consensus motif; other site
360115004260	active site
360115004261	AMP binding site [chemical binding]; other site
360115004262	CoA binding site [chemical binding]; other site
360115004263	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
360115004264	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
360115004265	active site
360115004266	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
360115004267	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
360115004268	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
360115004269	DsbD alpha interface [polypeptide binding]; other site
360115004270	catalytic residues [active]
360115004271	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
360115004272	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
360115004273	carboxyltransferase (CT) interaction site; other site
360115004274	biotinylation site [posttranslational modification]; other site
360115004275	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
360115004276	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
360115004277	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
360115004278	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
360115004279	ornithine cyclodeaminase; Validated; Region: PRK07589
360115004280	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
360115004281	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
360115004282	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
360115004283	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
360115004284	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
360115004285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
360115004286	active site
360115004287	motif I; other site
360115004288	motif II; other site
360115004289	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
360115004290	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
360115004291	putative ligand binding site [chemical binding]; other site
360115004292	putative NAD binding site [chemical binding]; other site
360115004293	putative catalytic site [active]
360115004294	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
360115004295	L-serine binding site [chemical binding]; other site
360115004296	ACT domain interface; other site
360115004297	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
360115004298	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
360115004299	Walker A motif; other site
360115004300	ATP binding site [chemical binding]; other site
360115004301	Walker B motif; other site
360115004302	arginine finger; other site
360115004303	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
360115004304	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
360115004305	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
360115004306	dimerization interface [polypeptide binding]; other site
360115004307	putative ATP binding site [chemical binding]; other site
360115004308	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
360115004309	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
360115004310	active site
360115004311	substrate binding site [chemical binding]; other site
360115004312	cosubstrate binding site; other site
360115004313	catalytic site [active]
360115004314	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
360115004315	IHF dimer interface [polypeptide binding]; other site
360115004316	IHF - DNA interface [nucleotide binding]; other site
360115004317	Predicted methyltransferases [General function prediction only]; Region: COG0313
360115004318	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
360115004319	putative SAM binding site [chemical binding]; other site
360115004320	putative homodimer interface [polypeptide binding]; other site
360115004321	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
360115004322	putative ligand binding site [chemical binding]; other site
360115004323	hypothetical protein; Provisional; Region: PRK14684
360115004324	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
360115004325	dimer interface [polypeptide binding]; other site
360115004326	active site
360115004327	BON domain; Region: BON; pfam04972
360115004328	BON domain; Region: BON; pfam04972
360115004329	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
360115004330	Peptidase family M50; Region: Peptidase_M50; pfam02163
360115004331	active site
360115004332	putative substrate binding region [chemical binding]; other site
360115004333	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
360115004334	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
360115004335	C-terminal domain interface [polypeptide binding]; other site
360115004336	putative GSH binding site (G-site) [chemical binding]; other site
360115004337	dimer interface [polypeptide binding]; other site
360115004338	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
360115004339	dimer interface [polypeptide binding]; other site
360115004340	N-terminal domain interface [polypeptide binding]; other site
360115004341	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
360115004342	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
360115004343	23S rRNA interface [nucleotide binding]; other site
360115004344	L3 interface [polypeptide binding]; other site
360115004345	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
360115004346	IHF dimer interface [polypeptide binding]; other site
360115004347	IHF - DNA interface [nucleotide binding]; other site
360115004348	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
360115004349	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
360115004350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115004351	putative substrate translocation pore; other site
360115004352	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004353	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004354	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004355	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
360115004356	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004357	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004358	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
360115004359	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004360	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004361	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004362	PAS fold; Region: PAS_4; pfam08448
360115004363	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
360115004364	putative active site [active]
360115004365	heme pocket [chemical binding]; other site
360115004366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
360115004367	dimer interface [polypeptide binding]; other site
360115004368	phosphorylation site [posttranslational modification]
360115004369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
360115004370	ATP binding site [chemical binding]; other site
360115004371	Mg2+ binding site [ion binding]; other site
360115004372	G-X-G motif; other site
360115004373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
360115004374	active site
360115004375	phosphorylation site [posttranslational modification]
360115004376	intermolecular recognition site; other site
360115004377	dimerization interface [polypeptide binding]; other site
360115004378	Hpt domain; Region: Hpt; pfam01627
360115004379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
360115004380	AAA domain; Region: AAA_14; pfam13173
360115004381	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
360115004382	FeoC like transcriptional regulator; Region: FeoC; pfam09012
360115004383	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
360115004384	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
360115004385	G1 box; other site
360115004386	GTP/Mg2+ binding site [chemical binding]; other site
360115004387	Switch I region; other site
360115004388	G2 box; other site
360115004389	G3 box; other site
360115004390	Switch II region; other site
360115004391	G4 box; other site
360115004392	G5 box; other site
360115004393	Nucleoside recognition; Region: Gate; pfam07670
360115004394	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
360115004395	Nucleoside recognition; Region: Gate; pfam07670
360115004396	FeoA domain; Region: FeoA; pfam04023
360115004397	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
360115004398	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
360115004399	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004400	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004401	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004402	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
360115004403	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
360115004404	Walker A/P-loop; other site
360115004405	ATP binding site [chemical binding]; other site
360115004406	Q-loop/lid; other site
360115004407	ABC transporter signature motif; other site
360115004408	Walker B; other site
360115004409	D-loop; other site
360115004410	H-loop/switch region; other site
360115004411	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
360115004412	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
360115004413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115004414	dimer interface [polypeptide binding]; other site
360115004415	conserved gate region; other site
360115004416	putative PBP binding loops; other site
360115004417	ABC-ATPase subunit interface; other site
360115004418	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
360115004419	G1 box; other site
360115004420	GTP/Mg2+ binding site [chemical binding]; other site
360115004421	Switch I region; other site
360115004422	G2 box; other site
360115004423	G3 box; other site
360115004424	Switch II region; other site
360115004425	G4 box; other site
360115004426	G5 box; other site
360115004427	bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772
360115004428	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
360115004429	Sel1-like repeats; Region: SEL1; smart00671
360115004430	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
360115004431	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
360115004432	intersubunit interface [polypeptide binding]; other site
360115004433	active site
360115004434	zinc binding site [ion binding]; other site
360115004435	Na+ binding site [ion binding]; other site
360115004436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004437	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004438	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004439	pyruvate kinase; Provisional; Region: PRK05826
360115004440	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
360115004441	domain interfaces; other site
360115004442	active site
360115004443	Phosphoglycerate kinase; Region: PGK; pfam00162
360115004444	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
360115004445	substrate binding site [chemical binding]; other site
360115004446	hinge regions; other site
360115004447	ADP binding site [chemical binding]; other site
360115004448	catalytic site [active]
360115004449	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
360115004450	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
360115004451	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
360115004452	transketolase; Reviewed; Region: PRK12753
360115004453	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
360115004454	TPP-binding site [chemical binding]; other site
360115004455	dimer interface [polypeptide binding]; other site
360115004456	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
360115004457	PYR/PP interface [polypeptide binding]; other site
360115004458	dimer interface [polypeptide binding]; other site
360115004459	TPP binding site [chemical binding]; other site
360115004460	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
360115004461	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004462	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004463	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004464	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
360115004465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115004466	Walker A motif; other site
360115004467	ATP binding site [chemical binding]; other site
360115004468	Walker B motif; other site
360115004469	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
360115004470	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
360115004471	glutaminase active site [active]
360115004472	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
360115004473	dimer interface [polypeptide binding]; other site
360115004474	active site
360115004475	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
360115004476	dimer interface [polypeptide binding]; other site
360115004477	active site
360115004478	ORF6N domain; Region: ORF6N; pfam10543
360115004479	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
360115004480	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
360115004481	DNA polymerase I; Provisional; Region: PRK05755
360115004482	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
360115004483	active site
360115004484	metal binding site 1 [ion binding]; metal-binding site
360115004485	putative 5' ssDNA interaction site; other site
360115004486	metal binding site 3; metal-binding site
360115004487	metal binding site 2 [ion binding]; metal-binding site
360115004488	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
360115004489	putative DNA binding site [nucleotide binding]; other site
360115004490	putative metal binding site [ion binding]; other site
360115004491	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
360115004492	active site
360115004493	catalytic site [active]
360115004494	substrate binding site [chemical binding]; other site
360115004495	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
360115004496	active site
360115004497	DNA binding site [nucleotide binding]
360115004498	catalytic site [active]
360115004499	amino acid transporter; Region: 2A0306; TIGR00909
360115004500	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
360115004501	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
360115004502	K+ potassium transporter; Region: K_trans; cl15781
360115004503	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
360115004504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
360115004505	Coenzyme A binding pocket [chemical binding]; other site
360115004506	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
360115004507	acetylornithine transaminase; Region: PLN00144
360115004508	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
360115004509	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
360115004510	DNA binding residues [nucleotide binding]
360115004511	dimerization interface [polypeptide binding]; other site
360115004512	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
360115004513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
360115004514	DNA binding residues [nucleotide binding]
360115004515	dimerization interface [polypeptide binding]; other site
360115004516	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
360115004517	HlyD family secretion protein; Region: HlyD_3; pfam13437
360115004518	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
360115004519	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
360115004520	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
360115004521	ligand binding site [chemical binding]; other site
360115004522	NAD binding site [chemical binding]; other site
360115004523	catalytic site [active]
360115004524	homodimer interface [polypeptide binding]; other site
360115004525	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
360115004526	primosome assembly protein PriA; Validated; Region: PRK05580
360115004527	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
360115004528	ATP binding site [chemical binding]; other site
360115004529	putative Mg++ binding site [ion binding]; other site
360115004530	helicase superfamily c-terminal domain; Region: HELICc; smart00490
360115004531	elongation factor P; Validated; Region: PRK00529
360115004532	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
360115004533	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
360115004534	RNA binding site [nucleotide binding]; other site
360115004535	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
360115004536	RNA binding site [nucleotide binding]; other site
360115004537	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
360115004538	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
360115004539	motif 1; other site
360115004540	dimer interface [polypeptide binding]; other site
360115004541	active site
360115004542	motif 2; other site
360115004543	motif 3; other site
360115004544	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
360115004545	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
360115004546	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
360115004547	E-class dimer interface [polypeptide binding]; other site
360115004548	P-class dimer interface [polypeptide binding]; other site
360115004549	active site
360115004550	Cu2+ binding site [ion binding]; other site
360115004551	Zn2+ binding site [ion binding]; other site
360115004552	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
360115004553	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
360115004554	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
360115004555	active site
360115004556	NTP binding site [chemical binding]; other site
360115004557	metal binding triad [ion binding]; metal-binding site
360115004558	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
360115004559	Uncharacterized conserved protein [Function unknown]; Region: COG1565
360115004560	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
360115004561	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
360115004562	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
360115004563	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
360115004564	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
360115004565	active site
360115004566	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
360115004567	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
360115004568	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
360115004569	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
360115004570	substrate binding site; other site
360115004571	tetramer interface; other site
360115004572	hypothetical protein; Provisional; Region: PRK07208
360115004573	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
360115004574	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
360115004575	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
360115004576	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
360115004577	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
360115004578	extended (e) SDRs; Region: SDR_e; cd08946
360115004579	NAD(P) binding site [chemical binding]; other site
360115004580	active site
360115004581	substrate binding site [chemical binding]; other site
360115004582	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
360115004583	hydroxyglutarate oxidase; Provisional; Region: PRK11728
360115004584	Predicted dehydrogenase [General function prediction only]; Region: COG0579
360115004585	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
360115004586	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
360115004587	5S rRNA interface [nucleotide binding]; other site
360115004588	CTC domain interface [polypeptide binding]; other site
360115004589	L16 interface [polypeptide binding]; other site
360115004590	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
360115004591	putative active site [active]
360115004592	catalytic residue [active]
360115004593	GTP-binding protein YchF; Reviewed; Region: PRK09601
360115004594	YchF GTPase; Region: YchF; cd01900
360115004595	G1 box; other site
360115004596	GTP/Mg2+ binding site [chemical binding]; other site
360115004597	Switch I region; other site
360115004598	G2 box; other site
360115004599	Switch II region; other site
360115004600	G3 box; other site
360115004601	G4 box; other site
360115004602	G5 box; other site
360115004603	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
360115004604	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
360115004605	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
360115004606	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
360115004607	Predicted membrane protein [Function unknown]; Region: COG2246
360115004608	GtrA-like protein; Region: GtrA; pfam04138
360115004609	TPR repeat; Region: TPR_11; pfam13414
360115004610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115004611	binding surface
360115004612	TPR motif; other site
360115004613	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
360115004614	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
360115004615	substrate binding site [chemical binding]; other site
360115004616	oxyanion hole (OAH) forming residues; other site
360115004617	trimer interface [polypeptide binding]; other site
360115004618	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
360115004619	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
360115004620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115004621	dimer interface [polypeptide binding]; other site
360115004622	conserved gate region; other site
360115004623	putative PBP binding loops; other site
360115004624	ABC-ATPase subunit interface; other site
360115004625	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
360115004626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
360115004627	dimer interface [polypeptide binding]; other site
360115004628	conserved gate region; other site
360115004629	putative PBP binding loops; other site
360115004630	ABC-ATPase subunit interface; other site
360115004631	Radical SAM superfamily; Region: Radical_SAM; pfam04055
360115004632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
360115004633	FeS/SAM binding site; other site
360115004634	Bacterial PH domain; Region: DUF304; pfam03703
360115004635	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
360115004636	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
360115004637	CAP-like domain; other site
360115004638	active site
360115004639	primary dimer interface [polypeptide binding]; other site
360115004640	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
360115004641	diiron binding motif [ion binding]; other site
360115004642	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
360115004643	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
360115004644	substrate binding site [chemical binding]; other site
360115004645	hexamer interface [polypeptide binding]; other site
360115004646	metal binding site [ion binding]; metal-binding site
360115004647	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
360115004648	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
360115004649	putative metal binding site [ion binding]; other site
360115004650	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
360115004651	HSP70 interaction site [polypeptide binding]; other site
360115004652	Glutamate-cysteine ligase; Region: GshA; pfam08886
360115004653	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
360115004654	glutathione synthetase; Provisional; Region: PRK05246
360115004655	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
360115004656	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
360115004657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115004658	S-adenosylmethionine binding site [chemical binding]; other site
360115004659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
360115004660	Walker A motif; other site
360115004661	ATP binding site [chemical binding]; other site
360115004662	Walker B motif; other site
360115004663	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
360115004664	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
360115004665	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
360115004666	active site
360115004667	catalytic residues [active]
360115004668	metal binding site [ion binding]; metal-binding site
360115004669	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
360115004670	Rubredoxin [Energy production and conversion]; Region: COG1773
360115004671	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
360115004672	iron binding site [ion binding]; other site
360115004673	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
360115004674	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
360115004675	inhibitor-cofactor binding pocket; inhibition site
360115004676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
360115004677	catalytic residue [active]
360115004678	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
360115004679	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
360115004680	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
360115004681	Transglycosylase; Region: Transgly; pfam00912
360115004682	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
360115004683	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
360115004684	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
360115004685	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
360115004686	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
360115004687	shikimate kinase; Reviewed; Region: aroK; PRK00131
360115004688	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
360115004689	ADP binding site [chemical binding]; other site
360115004690	magnesium binding site [ion binding]; other site
360115004691	putative shikimate binding site; other site
360115004692	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
360115004693	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
360115004694	active site
360115004695	dimer interface [polypeptide binding]; other site
360115004696	metal binding site [ion binding]; metal-binding site
360115004697	H+ Antiporter protein; Region: 2A0121; TIGR00900
360115004698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115004699	putative substrate translocation pore; other site
360115004700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004701	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004702	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004703	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
360115004704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115004705	S-adenosylmethionine binding site [chemical binding]; other site
360115004706	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
360115004707	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
360115004708	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
360115004709	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
360115004710	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
360115004711	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
360115004712	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
360115004713	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
360115004714	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
360115004715	P loop; other site
360115004716	GTP binding site [chemical binding]; other site
360115004717	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
360115004718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
360115004719	Walker A/P-loop; other site
360115004720	ATP binding site [chemical binding]; other site
360115004721	Q-loop/lid; other site
360115004722	ABC transporter signature motif; other site
360115004723	Walker B; other site
360115004724	D-loop; other site
360115004725	H-loop/switch region; other site
360115004726	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
360115004727	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
360115004728	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
360115004729	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
360115004730	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
360115004731	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
360115004732	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
360115004733	DNA binding residues [nucleotide binding]
360115004734	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
360115004735	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
360115004736	catalytic residues [active]
360115004737	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
360115004738	dimer interface [polypeptide binding]; other site
360115004739	motif 1; other site
360115004740	active site
360115004741	motif 2; other site
360115004742	motif 3; other site
360115004743	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
360115004744	DALR anticodon binding domain; Region: DALR_1; pfam05746
360115004745	16S rRNA methyltransferase B; Provisional; Region: PRK10901
360115004746	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
360115004747	putative RNA binding site [nucleotide binding]; other site
360115004748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115004749	S-adenosylmethionine binding site [chemical binding]; other site
360115004750	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
360115004751	Ligand Binding Site [chemical binding]; other site
360115004752	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
360115004753	Ribonuclease P; Region: Ribonuclease_P; pfam00825
360115004754	hypothetical protein; Provisional; Region: PRK14384
360115004755	membrane protein insertase; Provisional; Region: PRK01318
360115004756	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
360115004757	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
360115004758	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
360115004759	trmE is a tRNA modification GTPase; Region: trmE; cd04164
360115004760	G1 box; other site
360115004761	GTP/Mg2+ binding site [chemical binding]; other site
360115004762	Switch I region; other site
360115004763	G2 box; other site
360115004764	Switch II region; other site
360115004765	G3 box; other site
360115004766	G4 box; other site
360115004767	G5 box; other site
360115004768	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
360115004769	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
360115004770	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
360115004771	NAD binding site [chemical binding]; other site
360115004772	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
360115004773	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
360115004774	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
360115004775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
360115004776	S-adenosylmethionine binding site [chemical binding]; other site
360115004777	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
360115004778	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
360115004779	P-loop; other site
360115004780	Magnesium ion binding site [ion binding]; other site
360115004781	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
360115004782	Magnesium ion binding site [ion binding]; other site
360115004783	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
360115004784	ParB-like nuclease domain; Region: ParB; smart00470
360115004785	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
360115004786	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
360115004787	acyl-activating enzyme (AAE) consensus motif; other site
360115004788	active site
360115004789	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
360115004790	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
360115004791	putative acyl-acceptor binding pocket; other site
360115004792	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
360115004793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115004794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
360115004795	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
360115004796	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
360115004797	putative DNA binding site [nucleotide binding]; other site
360115004798	putative homodimer interface [polypeptide binding]; other site
360115004799	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
360115004800	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
360115004801	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
360115004802	active site
360115004803	DNA binding site [nucleotide binding]
360115004804	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
360115004805	DNA binding site [nucleotide binding]
360115004806	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
360115004807	nucleotide binding site [chemical binding]; other site
360115004808	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
360115004809	ATP synthase I chain; Region: ATP_synt_I; cl09170
360115004810	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
360115004811	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
360115004812	ATP synthase subunit C; Region: ATP-synt_C; cl00466
360115004813	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
360115004814	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
360115004815	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
360115004816	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
360115004817	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
360115004818	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
360115004819	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
360115004820	beta subunit interaction interface [polypeptide binding]; other site
360115004821	Walker A motif; other site
360115004822	ATP binding site [chemical binding]; other site
360115004823	Walker B motif; other site
360115004824	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
360115004825	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
360115004826	core domain interface [polypeptide binding]; other site
360115004827	delta subunit interface [polypeptide binding]; other site
360115004828	epsilon subunit interface [polypeptide binding]; other site
360115004829	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
360115004830	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
360115004831	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
360115004832	alpha subunit interaction interface [polypeptide binding]; other site
360115004833	Walker A motif; other site
360115004834	ATP binding site [chemical binding]; other site
360115004835	Walker B motif; other site
360115004836	inhibitor binding site; inhibition site
360115004837	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
360115004838	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
360115004839	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
360115004840	gamma subunit interface [polypeptide binding]; other site
360115004841	epsilon subunit interface [polypeptide binding]; other site
360115004842	LBP interface [polypeptide binding]; other site
360115004843	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
360115004844	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
360115004845	Substrate binding site; other site
360115004846	Mg++ binding site; other site
360115004847	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
360115004848	active site
360115004849	substrate binding site [chemical binding]; other site
360115004850	CoA binding site [chemical binding]; other site
360115004851	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
360115004852	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
360115004853	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
360115004854	ABC transporter; Region: ABC_tran_2; pfam12848
360115004855	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
360115004856	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
360115004857	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
360115004858	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
360115004859	ligand binding site [chemical binding]; other site
360115004860	homodimer interface [polypeptide binding]; other site
360115004861	NAD(P) binding site [chemical binding]; other site
360115004862	trimer interface B [polypeptide binding]; other site
360115004863	trimer interface A [polypeptide binding]; other site
360115004864	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
360115004865	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
360115004866	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
360115004867	RNA methyltransferase, RsmE family; Region: TIGR00046
360115004868	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
360115004869	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004870	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004871	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
360115004872	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
360115004873	active site
360115004874	Zn binding site [ion binding]; other site
360115004875	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
360115004876	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
360115004877	dimer interface [polypeptide binding]; other site
360115004878	active site
360115004879	CoA binding pocket [chemical binding]; other site
360115004880	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
360115004881	active site 2 [active]
360115004882	dimer interface [polypeptide binding]; other site
360115004883	active site 1 [active]
360115004884	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
360115004885	active site 2 [active]
360115004886	active site 1 [active]
360115004887	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
360115004888	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
360115004889	dimer interface [polypeptide binding]; other site
360115004890	active site
360115004891	acyl carrier protein; Provisional; Region: acpP; PRK00982
360115004892	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
360115004893	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
360115004894	helix swapped region; other site
360115004895	Hydroxymethylglutaryl-coenzyme A reductase; Region: HMG-CoA_red; pfam00368
360115004896	homodimer interface [polypeptide binding]; other site
360115004897	catalytic residues [active]
360115004898	substrate binding pocket [chemical binding]; other site
360115004899	NADH/NADPH cofactor binding site [chemical binding]; other site
360115004900	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
360115004901	putative acyl-acceptor binding pocket; other site
360115004902	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
360115004903	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
360115004904	FAD binding domain; Region: FAD_binding_4; pfam01565
360115004905	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
360115004906	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
360115004907	putative acyl-acceptor binding pocket; other site
360115004908	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
360115004909	tetramer (dimer of dimers) interface [polypeptide binding]; other site
360115004910	active site
360115004911	dimer interface [polypeptide binding]; other site
360115004912	carbon storage regulator; Provisional; Region: PRK01712
360115004913	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
360115004914	30S subunit binding site; other site
360115004915	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
360115004916	DNA-binding site [nucleotide binding]; DNA binding site
360115004917	RNA-binding motif; other site
360115004918	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
360115004919	intersubunit interface [polypeptide binding]; other site
360115004920	active site
360115004921	catalytic residue [active]
360115004922	purine nucleoside phosphorylase; Provisional; Region: PRK08202
360115004923	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
360115004924	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
360115004925	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
360115004926	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
360115004927	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
360115004928	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
360115004929	shikimate binding site; other site
360115004930	NAD(P) binding site [chemical binding]; other site
360115004931	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
360115004932	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
360115004933	Protein of unknown function (DUF497); Region: DUF497; pfam04365
360115004934	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
360115004935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004936	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004937	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
360115004939	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
360115004940	Ligand Binding Site [chemical binding]; other site
360115004941	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
360115004942	Predicted periplasmic protein [Function unknown]; Region: COG3698
360115004943	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
360115004944	HemY protein N-terminus; Region: HemY_N; pfam07219
360115004945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
360115004946	binding surface
360115004947	TPR motif; other site
360115004948	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
360115004949	Fic family protein [Function unknown]; Region: COG3177
360115004950	Fic/DOC family; Region: Fic; pfam02661
360115004951	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
360115004952	Transposase; Region: DEDD_Tnp_IS110; pfam01548
360115004953	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
360115004954	transcription termination factor Rho; Provisional; Region: rho; PRK09376
360115004955	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
360115004956	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
360115004957	RNA binding site [nucleotide binding]; other site
360115004958	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
360115004959	multimer interface [polypeptide binding]; other site
360115004960	Walker A motif; other site
360115004961	ATP binding site [chemical binding]; other site
360115004962	Walker B motif; other site
360115004963	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
360115004964	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
360115004965	catalytic residues [active]
360115004966	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
360115004967	Na2 binding site [ion binding]; other site
360115004968	putative substrate binding site 1 [chemical binding]; other site
360115004969	Na binding site 1 [ion binding]; other site
360115004970	putative substrate binding site 2 [chemical binding]; other site
360115004971	YGGT family; Region: YGGT; pfam02325
360115004972	YGGT family; Region: YGGT; pfam02325
360115004973	pyrroline-5-carboxylate reductase; Region: PLN02688
360115004974	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
360115004975	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
360115004976	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
360115004977	catalytic residue [active]
360115004978	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
360115004979	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
360115004980	active site
360115004981	substrate-binding site [chemical binding]; other site
360115004982	metal-binding site [ion binding]
360115004983	ATP binding site [chemical binding]; other site
360115004984	hypothetical protein; Validated; Region: PRK00228
360115004985	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
360115004986	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK13814
360115004987	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
360115004988	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185