-- dump date 20140619_053539 -- class Genbank::misc_feature -- table misc_feature_note -- id note 216432000001 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 216432000002 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 216432000003 G1 box; other site 216432000004 putative GEF interaction site [polypeptide binding]; other site 216432000005 GTP/Mg2+ binding site [chemical binding]; other site 216432000006 Switch I region; other site 216432000007 G2 box; other site 216432000008 G3 box; other site 216432000009 Switch II region; other site 216432000010 G4 box; other site 216432000011 G5 box; other site 216432000012 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 216432000013 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 216432000014 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 216432000015 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 216432000016 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 216432000017 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 216432000018 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 216432000019 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 216432000020 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216432000021 cleft; other site 216432000022 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 216432000023 Rpb1 - Rpb2 interaction site [polypeptide binding]; other site 216432000024 DNA binding site [nucleotide binding] 216432000025 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 216432000026 clamp; other site 216432000027 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 216432000028 DNA binding site [nucleotide binding] 216432000029 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 216432000030 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 216432000031 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 216432000032 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 216432000033 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216432000034 RPB11 interaction site [polypeptide binding]; other site 216432000035 RPB12 interaction site [polypeptide binding]; other site 216432000036 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216432000037 RPB1 interaction site [polypeptide binding]; other site 216432000038 RPB11 interaction site [polypeptide binding]; other site 216432000039 RPB10 interaction site [polypeptide binding]; other site 216432000040 RPB3 interaction site [polypeptide binding]; other site 216432000041 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 216432000042 core dimer interface [polypeptide binding]; other site 216432000043 peripheral dimer interface [polypeptide binding]; other site 216432000044 L10 interface [polypeptide binding]; other site 216432000045 L11 interface [polypeptide binding]; other site 216432000046 putative EF-Tu interaction site [polypeptide binding]; other site 216432000047 putative EF-G interaction site [polypeptide binding]; other site 216432000048 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 216432000049 23S rRNA interface [nucleotide binding]; other site 216432000050 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 216432000051 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 216432000052 mRNA/rRNA interface [nucleotide binding]; other site 216432000053 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 216432000054 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 216432000055 23S rRNA interface [nucleotide binding]; other site 216432000056 L7/L12 interface [polypeptide binding]; other site 216432000057 putative thiostrepton binding site; other site 216432000058 L25 interface [polypeptide binding]; other site 216432000059 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 216432000060 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 216432000061 putative homodimer interface [polypeptide binding]; other site 216432000062 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 216432000063 heterodimer interface [polypeptide binding]; other site 216432000064 homodimer interface [polypeptide binding]; other site 216432000065 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 216432000066 elongation factor Tu; Reviewed; Region: PRK12735 216432000067 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 216432000068 G1 box; other site 216432000069 GEF interaction site [polypeptide binding]; other site 216432000070 GTP/Mg2+ binding site [chemical binding]; other site 216432000071 Switch I region; other site 216432000072 G2 box; other site 216432000073 G3 box; other site 216432000074 Switch II region; other site 216432000075 G4 box; other site 216432000076 G5 box; other site 216432000077 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216432000078 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 216432000079 Antibiotic Binding Site [chemical binding]; other site 216432000080 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 216432000081 30S subunit binding site; other site 216432000082 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216432000083 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216432000084 active site 216432000085 DNA binding site [nucleotide binding] 216432000086 Int/Topo IB signature motif; other site 216432000087 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 216432000088 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 216432000089 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 216432000090 active site 216432000091 Ca binding site [ion binding]; other site 216432000092 catalytic site [active] 216432000093 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 216432000094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216432000095 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216432000096 active site 216432000097 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 216432000098 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 216432000099 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 216432000100 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 216432000101 Ion channel; Region: Ion_trans_2; pfam07885 216432000102 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 216432000103 TrkA-N domain; Region: TrkA_N; pfam02254 216432000104 TrkA-C domain; Region: TrkA_C; pfam02080 216432000105 PspC domain; Region: PspC; cl00864 216432000106 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 216432000107 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 216432000108 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 216432000109 active site 216432000110 catalytic residues [active] 216432000111 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 216432000112 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 216432000113 active site 216432000114 catalytic triad [active] 216432000115 oxyanion hole [active] 216432000116 Domain of unknown function (DUF202); Region: DUF202; pfam02656 216432000117 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216432000118 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216432000119 dimer interface [polypeptide binding]; other site 216432000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432000121 catalytic residue [active] 216432000122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216432000123 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 216432000124 FtsX-like permease family; Region: FtsX; pfam02687 216432000125 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 216432000126 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432000127 active site 216432000128 WxcM-like, C-terminal; Region: FdtA; pfam05523 216432000129 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216432000130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432000131 active site 216432000132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432000133 active site 216432000134 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 216432000135 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216432000136 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 216432000137 Walker A/P-loop; other site 216432000138 ATP binding site [chemical binding]; other site 216432000139 Q-loop/lid; other site 216432000140 ABC transporter signature motif; other site 216432000141 Walker B; other site 216432000142 D-loop; other site 216432000143 H-loop/switch region; other site 216432000144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432000145 binding surface 216432000146 TPR motif; other site 216432000147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432000148 TPR motif; other site 216432000149 binding surface 216432000150 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 216432000151 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 216432000152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432000153 binding surface 216432000154 TPR motif; other site 216432000155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216432000156 binding surface 216432000157 TPR motif; other site 216432000158 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 216432000159 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432000160 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 216432000161 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 216432000162 G1 box; other site 216432000163 putative GEF interaction site [polypeptide binding]; other site 216432000164 GTP/Mg2+ binding site [chemical binding]; other site 216432000165 Switch I region; other site 216432000166 G2 box; other site 216432000167 G3 box; other site 216432000168 Switch II region; other site 216432000169 G4 box; other site 216432000170 G5 box; other site 216432000171 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 216432000172 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 216432000173 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216432000174 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 216432000175 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 216432000176 Family description; Region: VCBS; pfam13517 216432000177 Family description; Region: VCBS; pfam13517 216432000178 Family description; Region: VCBS; pfam13517 216432000179 Family description; Region: VCBS; pfam13517 216432000180 Family description; Region: VCBS; pfam13517 216432000181 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 216432000182 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432000183 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 216432000184 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 216432000185 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 216432000186 active site 216432000187 ligand binding site [chemical binding]; other site 216432000188 NAD(P) binding site [chemical binding]; other site 216432000189 Uncharacterized conserved protein [Function unknown]; Region: COG4095 216432000190 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 216432000191 integron integrase; Region: integrase_gron; TIGR02249 216432000192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216432000193 active site 216432000194 DNA binding site [nucleotide binding] 216432000195 Int/Topo IB signature motif; other site 216432000196 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 216432000197 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 216432000198 cofactor binding site; other site 216432000199 DNA binding site [nucleotide binding] 216432000200 substrate interaction site [chemical binding]; other site 216432000201 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 216432000202 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 216432000203 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 216432000204 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 216432000205 Helix-turn-helix domain; Region: HTH_18; pfam12833 216432000206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216432000207 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216432000208 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216432000209 metal-binding site [ion binding] 216432000210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216432000211 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216432000212 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 216432000213 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 216432000214 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432000215 Divergent AAA domain; Region: AAA_4; pfam04326 216432000216 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 216432000217 catalytic motif [active] 216432000218 Catalytic residue [active] 216432000219 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 216432000220 Mg2+ binding site [ion binding]; other site 216432000221 G-X-G motif; other site 216432000222 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 216432000223 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 216432000224 AAA domain; Region: AAA_21; pfam13304 216432000225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432000226 ABC transporter signature motif; other site 216432000227 Walker B; other site 216432000228 D-loop; other site 216432000229 H-loop/switch region; other site 216432000230 Integrase core domain; Region: rve; pfam00665 216432000231 Integrase core domain; Region: rve_3; pfam13683 216432000232 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 216432000233 Helix-turn-helix domain; Region: HTH_17; pfam12728 216432000234 DNA methylase; Region: N6_N4_Mtase; cl17433 216432000235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432000236 non-specific DNA binding site [nucleotide binding]; other site 216432000237 salt bridge; other site 216432000238 sequence-specific DNA binding site [nucleotide binding]; other site 216432000239 Helix-turn-helix domain; Region: HTH_17; pfam12728 216432000240 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 216432000241 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216432000242 active site 216432000243 DNA binding site [nucleotide binding] 216432000244 Int/Topo IB signature motif; other site 216432000245 short chain dehydrogenase; Provisional; Region: PRK06197 216432000246 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 216432000247 putative NAD(P) binding site [chemical binding]; other site 216432000248 active site 216432000249 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216432000250 hydrophobic ligand binding site; other site 216432000251 Helix-turn-helix domain; Region: HTH_18; pfam12833 216432000252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216432000253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432000254 dimerization interface [polypeptide binding]; other site 216432000255 putative DNA binding site [nucleotide binding]; other site 216432000256 putative Zn2+ binding site [ion binding]; other site 216432000257 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 216432000258 Low molecular weight phosphatase family; Region: LMWPc; cl00105 216432000259 active site 216432000260 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 216432000261 arsenical-resistance protein; Region: acr3; TIGR00832 216432000262 TrkA-C domain; Region: TrkA_C; pfam02080 216432000263 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216432000264 Conserved TM helix; Region: TM_helix; pfam05552 216432000265 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432000266 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 216432000267 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216432000268 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 216432000269 putative active site [active] 216432000270 catalytic triad [active] 216432000271 putative dimer interface [polypeptide binding]; other site 216432000272 Deoxyhypusine synthase; Region: DS; cl00826 216432000273 deoxyhypusine synthase; Region: dhys; TIGR00321 216432000274 Deoxyhypusine synthase; Region: DS; cl00826 216432000275 agmatinase; Region: agmatinase; TIGR01230 216432000276 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 216432000277 putative active site [active] 216432000278 Mn binding site [ion binding]; other site 216432000279 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 216432000280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 216432000281 dimer interface [polypeptide binding]; other site 216432000282 active site 216432000283 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216432000284 catalytic residues [active] 216432000285 substrate binding site [chemical binding]; other site 216432000286 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 216432000287 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 216432000288 exosortase family protein XrtF; Region: exoso_Fjoh_1448; TIGR04128 216432000289 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 216432000290 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 216432000291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216432000292 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216432000293 FtsX-like permease family; Region: FtsX; pfam02687 216432000294 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 216432000295 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 216432000296 purine monophosphate binding site [chemical binding]; other site 216432000297 dimer interface [polypeptide binding]; other site 216432000298 putative catalytic residues [active] 216432000299 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 216432000300 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 216432000301 rod shape-determining protein MreB; Provisional; Region: PRK13927 216432000302 MreB and similar proteins; Region: MreB_like; cd10225 216432000303 nucleotide binding site [chemical binding]; other site 216432000304 Mg binding site [ion binding]; other site 216432000305 putative protofilament interaction site [polypeptide binding]; other site 216432000306 RodZ interaction site [polypeptide binding]; other site 216432000307 rod shape-determining protein MreC; Provisional; Region: PRK13922 216432000308 rod shape-determining protein MreC; Region: MreC; pfam04085 216432000309 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 216432000310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216432000311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216432000312 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 216432000313 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 216432000314 urocanate hydratase; Provisional; Region: PRK05414 216432000315 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 216432000316 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 216432000317 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432000318 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 216432000319 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432000320 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 216432000321 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 216432000322 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432000323 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 216432000324 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216432000325 inhibitor-cofactor binding pocket; inhibition site 216432000326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432000327 catalytic residue [active] 216432000328 GH3 auxin-responsive promoter; Region: GH3; pfam03321 216432000329 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 216432000330 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 216432000331 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 216432000332 active site 216432000333 substrate binding site [chemical binding]; other site 216432000334 Mg2+ binding site [ion binding]; other site 216432000335 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216432000336 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216432000337 ring oligomerisation interface [polypeptide binding]; other site 216432000338 ATP/Mg binding site [chemical binding]; other site 216432000339 stacking interactions; other site 216432000340 hinge regions; other site 216432000341 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 216432000342 oligomerisation interface [polypeptide binding]; other site 216432000343 mobile loop; other site 216432000344 roof hairpin; other site 216432000345 Preprotein translocase SecG subunit; Region: SecG; cl09123 216432000346 Lipopolysaccharide-assembly; Region: LptE; pfam04390 216432000347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432000348 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216432000349 Walker A motif; other site 216432000350 ATP binding site [chemical binding]; other site 216432000351 Walker B motif; other site 216432000352 arginine finger; other site 216432000353 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216432000354 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 216432000355 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216432000356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432000357 FeS/SAM binding site; other site 216432000358 TRAM domain; Region: TRAM; pfam01938 216432000359 Uncharacterized conserved protein [Function unknown]; Region: COG5276 216432000360 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 216432000361 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 216432000362 active site 216432000363 interdomain interaction site; other site 216432000364 putative metal-binding site [ion binding]; other site 216432000365 nucleotide binding site [chemical binding]; other site 216432000366 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 216432000367 domain I; other site 216432000368 DNA binding groove [nucleotide binding] 216432000369 phosphate binding site [ion binding]; other site 216432000370 domain II; other site 216432000371 domain III; other site 216432000372 nucleotide binding site [chemical binding]; other site 216432000373 catalytic site [active] 216432000374 domain IV; other site 216432000375 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216432000376 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216432000377 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 216432000378 putative active site [active] 216432000379 putative metal binding site [ion binding]; other site 216432000380 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 216432000381 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 216432000382 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 216432000383 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216432000384 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 216432000385 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 216432000386 GldM N-terminal domain; Region: GldM_N; pfam12081 216432000387 GldM C-terminal domain; Region: GldM_C; pfam12080 216432000388 gliding motility associated protien GldN; Region: GldN; TIGR03523 216432000389 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216432000390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216432000391 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 216432000392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216432000393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432000394 NifU-like domain; Region: NifU; cl00484 216432000395 Domain of unknown function DUF59; Region: DUF59; pfam01883 216432000396 septum site-determining protein MinD; Region: minD_bact; TIGR01968 216432000397 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 216432000398 Walker A motif; other site 216432000399 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 216432000400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216432000401 RNA binding surface [nucleotide binding]; other site 216432000402 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 216432000403 active site 216432000404 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 216432000405 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 216432000406 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 216432000407 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 216432000408 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 216432000409 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 216432000410 GTP cyclohydrolase I; Provisional; Region: PLN03044 216432000411 active site 216432000412 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 216432000413 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432000414 active site 216432000415 HIGH motif; other site 216432000416 nucleotide binding site [chemical binding]; other site 216432000417 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216432000418 KMSKS motif; other site 216432000419 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216432000420 Haemolytic domain; Region: Haemolytic; pfam01809 216432000421 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 216432000422 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 216432000423 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 216432000424 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 216432000425 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 216432000426 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 216432000427 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 216432000428 active site 216432000429 dimer interface [polypeptide binding]; other site 216432000430 motif 1; other site 216432000431 motif 2; other site 216432000432 motif 3; other site 216432000433 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 216432000434 anticodon binding site; other site 216432000435 translation initiation factor IF-3; Region: infC; TIGR00168 216432000436 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 216432000437 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 216432000438 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 216432000439 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 216432000440 23S rRNA binding site [nucleotide binding]; other site 216432000441 L21 binding site [polypeptide binding]; other site 216432000442 L13 binding site [polypeptide binding]; other site 216432000443 replicative DNA helicase; Region: DnaB; TIGR00665 216432000444 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 216432000445 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 216432000446 Walker A motif; other site 216432000447 ATP binding site [chemical binding]; other site 216432000448 Walker B motif; other site 216432000449 DNA binding loops [nucleotide binding] 216432000450 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 216432000451 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 216432000452 EamA-like transporter family; Region: EamA; pfam00892 216432000453 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216432000454 Predicted permeases [General function prediction only]; Region: COG0795 216432000455 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216432000456 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 216432000457 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 216432000458 transketolase; Reviewed; Region: PRK05899 216432000459 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216432000460 TPP-binding site [chemical binding]; other site 216432000461 dimer interface [polypeptide binding]; other site 216432000462 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 216432000463 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216432000464 PYR/PP interface [polypeptide binding]; other site 216432000465 dimer interface [polypeptide binding]; other site 216432000466 TPP binding site [chemical binding]; other site 216432000467 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216432000468 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 216432000469 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216432000470 RNA binding surface [nucleotide binding]; other site 216432000471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432000472 S-adenosylmethionine binding site [chemical binding]; other site 216432000473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432000474 active site 216432000475 Shikimate kinase; Region: SKI; pfam01202 216432000476 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 216432000477 ADP binding site [chemical binding]; other site 216432000478 magnesium binding site [ion binding]; other site 216432000479 putative shikimate binding site; other site 216432000480 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216432000481 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 216432000482 DNA binding residues [nucleotide binding] 216432000483 B12 binding domain; Region: B12-binding_2; pfam02607 216432000484 phytoene desaturase; Region: crtI_fam; TIGR02734 216432000485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216432000486 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 216432000487 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 216432000488 active site lid residues [active] 216432000489 substrate binding pocket [chemical binding]; other site 216432000490 catalytic residues [active] 216432000491 substrate-Mg2+ binding site; other site 216432000492 aspartate-rich region 1; other site 216432000493 aspartate-rich region 2; other site 216432000494 beta-carotene hydroxylase; Region: PLN02601 216432000495 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 216432000496 lycopene cyclase; Region: lycopene_cycl; TIGR01789 216432000497 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432000498 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432000499 catalytic residues [active] 216432000500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216432000501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432000502 non-specific DNA binding site [nucleotide binding]; other site 216432000503 salt bridge; other site 216432000504 sequence-specific DNA binding site [nucleotide binding]; other site 216432000505 Predicted transcriptional regulator [Transcription]; Region: COG2932 216432000506 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216432000507 Catalytic site [active] 216432000508 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 216432000509 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 216432000510 substrate binding site [chemical binding]; other site 216432000511 ligand binding site [chemical binding]; other site 216432000512 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 216432000513 substrate binding site [chemical binding]; other site 216432000514 MoxR-like ATPases [General function prediction only]; Region: COG0714 216432000515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432000516 Walker A motif; other site 216432000517 ATP binding site [chemical binding]; other site 216432000518 Walker B motif; other site 216432000519 arginine finger; other site 216432000520 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 216432000521 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216432000522 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216432000523 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216432000524 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216432000525 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 216432000526 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216432000527 hydrophobic ligand binding site; other site 216432000528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 216432000529 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 216432000530 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 216432000531 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 216432000532 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216432000533 FMN binding site [chemical binding]; other site 216432000534 substrate binding site [chemical binding]; other site 216432000535 putative catalytic residue [active] 216432000536 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 216432000537 OsmC-like protein; Region: OsmC; pfam02566 216432000538 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432000539 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432000540 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 216432000541 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432000542 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432000543 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 216432000544 ligand binding site [chemical binding]; other site 216432000545 GMP synthase; Reviewed; Region: guaA; PRK00074 216432000546 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 216432000547 AMP/PPi binding site [chemical binding]; other site 216432000548 candidate oxyanion hole; other site 216432000549 catalytic triad [active] 216432000550 potential glutamine specificity residues [chemical binding]; other site 216432000551 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 216432000552 ATP Binding subdomain [chemical binding]; other site 216432000553 Ligand Binding sites [chemical binding]; other site 216432000554 Dimerization subdomain; other site 216432000555 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 216432000556 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 216432000557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 216432000558 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 216432000559 putative active site [active] 216432000560 Zn binding site [ion binding]; other site 216432000561 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 216432000562 conserved cys residue [active] 216432000563 Domain of unknown function DUF11; Region: DUF11; pfam01345 216432000564 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 216432000565 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 216432000566 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 216432000567 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432000568 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432000569 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432000570 ligand binding site [chemical binding]; other site 216432000571 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 216432000572 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 216432000573 transcription termination factor Rho; Provisional; Region: PRK12608 216432000574 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 216432000575 RNA binding site [nucleotide binding]; other site 216432000576 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 216432000577 multimer interface [polypeptide binding]; other site 216432000578 Walker A motif; other site 216432000579 ATP binding site [chemical binding]; other site 216432000580 Walker B motif; other site 216432000581 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 216432000582 prolyl-tRNA synthetase; Provisional; Region: PRK08661 216432000583 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 216432000584 dimer interface [polypeptide binding]; other site 216432000585 motif 1; other site 216432000586 active site 216432000587 motif 2; other site 216432000588 motif 3; other site 216432000589 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 216432000590 anticodon binding site; other site 216432000591 zinc-binding site [ion binding]; other site 216432000592 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 216432000593 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 216432000594 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 216432000595 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 216432000596 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 216432000597 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216432000598 Dodecin; Region: Dodecin; pfam07311 216432000599 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 216432000600 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 216432000601 catalytic residues [active] 216432000602 Conserved TM helix; Region: TM_helix; pfam05552 216432000603 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432000604 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 216432000605 Glycoprotease family; Region: Peptidase_M22; pfam00814 216432000606 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216432000607 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216432000608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216432000609 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432000610 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216432000611 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216432000612 FtsX-like permease family; Region: FtsX; pfam02687 216432000613 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216432000614 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216432000615 FtsX-like permease family; Region: FtsX; pfam02687 216432000616 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216432000617 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216432000618 Walker A/P-loop; other site 216432000619 ATP binding site [chemical binding]; other site 216432000620 Q-loop/lid; other site 216432000621 ABC transporter signature motif; other site 216432000622 Walker B; other site 216432000623 D-loop; other site 216432000624 H-loop/switch region; other site 216432000625 Protein of unknown function (DUF420); Region: DUF420; pfam04238 216432000626 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 216432000627 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 216432000628 Cu(I) binding site [ion binding]; other site 216432000629 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 216432000630 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 216432000631 Subunit I/III interface [polypeptide binding]; other site 216432000632 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 216432000633 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 216432000634 Subunit I/III interface [polypeptide binding]; other site 216432000635 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 216432000636 UbiA prenyltransferase family; Region: UbiA; pfam01040 216432000637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216432000638 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216432000639 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 216432000640 VanZ like family; Region: VanZ; cl01971 216432000641 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 216432000642 lipoyl attachment site [posttranslational modification]; other site 216432000643 Motility related/secretion protein; Region: SprA_N; pfam14349 216432000644 cell surface protein SprA; Region: surface_SprA; TIGR04189 216432000645 Motility related/secretion protein; Region: SprA_N; pfam14349 216432000646 Motility related/secretion protein; Region: SprA_N; pfam14349 216432000647 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 216432000648 RuvA N terminal domain; Region: RuvA_N; pfam01330 216432000649 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 216432000650 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 216432000651 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216432000652 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 216432000653 putative NAD(P) binding site [chemical binding]; other site 216432000654 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 216432000655 Uncharacterized conserved protein [Function unknown]; Region: COG3339 216432000656 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216432000657 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 216432000658 putative substrate binding site [chemical binding]; other site 216432000659 putative ATP binding site [chemical binding]; other site 216432000660 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 216432000661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216432000662 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 216432000663 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216432000664 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432000665 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216432000666 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432000667 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432000668 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216432000669 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216432000670 DNA binding site [nucleotide binding] 216432000671 domain linker motif; other site 216432000672 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216432000673 dimerization interface [polypeptide binding]; other site 216432000674 ligand binding site [chemical binding]; other site 216432000675 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 216432000676 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 216432000677 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 216432000678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432000679 Walker A motif; other site 216432000680 ATP binding site [chemical binding]; other site 216432000681 Walker B motif; other site 216432000682 arginine finger; other site 216432000683 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 216432000684 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 216432000685 putative catalytic residues [active] 216432000686 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 216432000687 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 216432000688 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 216432000689 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 216432000690 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 216432000691 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 216432000692 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216432000693 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 216432000694 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 216432000695 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 216432000696 Uncharacterized conserved protein [Function unknown]; Region: COG3743 216432000697 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216432000698 molybdopterin cofactor binding site; other site 216432000699 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 216432000700 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 216432000701 4Fe-4S binding domain; Region: Fer4; cl02805 216432000702 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216432000703 Cytochrome c; Region: Cytochrom_C; pfam00034 216432000704 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 216432000705 heme-binding residues [chemical binding]; other site 216432000706 Sporulation related domain; Region: SPOR; cl10051 216432000707 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432000708 translation initiation factor IF-2; Region: IF-2; TIGR00487 216432000709 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216432000710 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 216432000711 G1 box; other site 216432000712 putative GEF interaction site [polypeptide binding]; other site 216432000713 GTP/Mg2+ binding site [chemical binding]; other site 216432000714 Switch I region; other site 216432000715 G2 box; other site 216432000716 G3 box; other site 216432000717 Switch II region; other site 216432000718 G4 box; other site 216432000719 G5 box; other site 216432000720 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 216432000721 Translation-initiation factor 2; Region: IF-2; pfam11987 216432000722 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 216432000723 transcription termination factor NusA; Region: NusA; TIGR01953 216432000724 NusA N-terminal domain; Region: NusA_N; pfam08529 216432000725 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 216432000726 RNA binding site [nucleotide binding]; other site 216432000727 homodimer interface [polypeptide binding]; other site 216432000728 NusA-like KH domain; Region: KH_5; pfam13184 216432000729 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216432000730 G-X-X-G motif; other site 216432000731 ribosome maturation protein RimP; Reviewed; Region: PRK00092 216432000732 hypothetical protein; Validated; Region: PRK02001 216432000733 heptamer interface [polypeptide binding]; other site 216432000734 Sm1 motif; other site 216432000735 hexamer interface [polypeptide binding]; other site 216432000736 RNA binding site [nucleotide binding]; other site 216432000737 Sm2 motif; other site 216432000738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216432000739 Ligand Binding Site [chemical binding]; other site 216432000740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216432000741 Ligand Binding Site [chemical binding]; other site 216432000742 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 216432000743 putative active site [active] 216432000744 putative metal binding site [ion binding]; other site 216432000745 phosphodiesterase YaeI; Provisional; Region: PRK11340 216432000746 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 216432000747 putative active site [active] 216432000748 putative metal binding site [ion binding]; other site 216432000749 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216432000750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432000751 catalytic residues [active] 216432000752 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216432000753 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 216432000754 NodB motif; other site 216432000755 active site 216432000756 catalytic site [active] 216432000757 metal binding site [ion binding]; metal-binding site 216432000758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432000759 putative substrate translocation pore; other site 216432000760 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216432000761 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216432000762 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 216432000763 PA/protease or protease-like domain interface [polypeptide binding]; other site 216432000764 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 216432000765 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216432000766 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 216432000767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 216432000768 Protein of unknown function, DUF547; Region: DUF547; pfam04784 216432000769 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 216432000770 gamma subunit interface [polypeptide binding]; other site 216432000771 LBP interface [polypeptide binding]; other site 216432000772 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 216432000773 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216432000774 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 216432000775 alpha subunit interaction interface [polypeptide binding]; other site 216432000776 Walker A motif; other site 216432000777 ATP binding site [chemical binding]; other site 216432000778 Walker B motif; other site 216432000779 inhibitor binding site; inhibition site 216432000780 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216432000781 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 216432000782 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 216432000783 glutaminase active site [active] 216432000784 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216432000785 dimer interface [polypeptide binding]; other site 216432000786 active site 216432000787 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216432000788 dimer interface [polypeptide binding]; other site 216432000789 active site 216432000790 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 216432000791 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 216432000792 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 216432000793 pantoate--beta-alanine ligase; Region: panC; TIGR00018 216432000794 active site 216432000795 nucleotide binding site [chemical binding]; other site 216432000796 HIGH motif; other site 216432000797 KMSKS motif; other site 216432000798 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 216432000799 tetramerization interface [polypeptide binding]; other site 216432000800 active site 216432000801 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 216432000802 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 216432000803 HYR domain; Region: HYR; pfam02494 216432000804 HYR domain; Region: HYR; pfam02494 216432000805 HYR domain; Region: HYR; pfam02494 216432000806 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432000807 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432000808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216432000809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432000810 active site 216432000811 phosphorylation site [posttranslational modification] 216432000812 intermolecular recognition site; other site 216432000813 dimerization interface [polypeptide binding]; other site 216432000814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216432000815 DNA binding residues [nucleotide binding] 216432000816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216432000817 Histidine kinase; Region: HisKA_3; pfam07730 216432000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432000819 ATP binding site [chemical binding]; other site 216432000820 Mg2+ binding site [ion binding]; other site 216432000821 G-X-G motif; other site 216432000822 DNA repair protein RadA; Provisional; Region: PRK11823 216432000823 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 216432000824 Walker A motif/ATP binding site; other site 216432000825 ATP binding site [chemical binding]; other site 216432000826 Walker B motif; other site 216432000827 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216432000828 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216432000829 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432000830 Bacterial SH3 domain homologues; Region: SH3b; smart00287 216432000831 acyl-coenzyme A oxidase; Region: PLN02526 216432000832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216432000833 active site 216432000834 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 216432000835 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 216432000836 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216432000837 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432000838 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432000839 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432000840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432000841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432000842 dimer interface [polypeptide binding]; other site 216432000843 phosphorylation site [posttranslational modification] 216432000844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432000845 ATP binding site [chemical binding]; other site 216432000846 Mg2+ binding site [ion binding]; other site 216432000847 G-X-G motif; other site 216432000848 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216432000849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432000850 active site 216432000851 phosphorylation site [posttranslational modification] 216432000852 intermolecular recognition site; other site 216432000853 dimerization interface [polypeptide binding]; other site 216432000854 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216432000855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432000856 active site 216432000857 phosphorylation site [posttranslational modification] 216432000858 intermolecular recognition site; other site 216432000859 dimerization interface [polypeptide binding]; other site 216432000860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432000861 Walker A motif; other site 216432000862 ATP binding site [chemical binding]; other site 216432000863 Walker B motif; other site 216432000864 arginine finger; other site 216432000865 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216432000866 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 216432000867 hypothetical protein; Provisional; Region: PRK09256 216432000868 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 216432000869 AAA domain; Region: AAA_28; pfam13521 216432000870 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 216432000871 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 216432000872 Domain of unknown function DUF77; Region: DUF77; cl00307 216432000873 GTPase Era; Reviewed; Region: era; PRK00089 216432000874 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 216432000875 G1 box; other site 216432000876 GTP/Mg2+ binding site [chemical binding]; other site 216432000877 Switch I region; other site 216432000878 G2 box; other site 216432000879 Switch II region; other site 216432000880 G3 box; other site 216432000881 G4 box; other site 216432000882 G5 box; other site 216432000883 KH domain; Region: KH_2; pfam07650 216432000884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432000885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216432000886 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432000887 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432000888 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216432000889 N-terminal plug; other site 216432000890 ligand-binding site [chemical binding]; other site 216432000891 transcription elongation factor regulatory protein; Validated; Region: PRK06342 216432000892 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216432000893 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 216432000894 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 216432000895 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216432000896 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216432000897 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216432000898 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432000899 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 216432000900 Predicted membrane protein [Function unknown]; Region: COG2259 216432000901 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 216432000902 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 216432000903 active site 216432000904 HIGH motif; other site 216432000905 dimer interface [polypeptide binding]; other site 216432000906 KMSKS motif; other site 216432000907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 216432000908 RNA binding surface [nucleotide binding]; other site 216432000909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216432000910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432000911 NAD(P) binding site [chemical binding]; other site 216432000912 active site 216432000913 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 216432000914 dihydroorotase; Reviewed; Region: PRK09236 216432000915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432000916 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 216432000917 active site 216432000918 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 216432000919 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 216432000920 Ligand binding site; other site 216432000921 Putative Catalytic site; other site 216432000922 DXD motif; other site 216432000923 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 216432000924 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 216432000925 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 216432000926 active site 216432000927 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 216432000928 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 216432000929 active site 216432000930 substrate-binding site [chemical binding]; other site 216432000931 metal-binding site [ion binding] 216432000932 ATP binding site [chemical binding]; other site 216432000933 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 216432000934 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 216432000935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432000936 NAD(P) binding site [chemical binding]; other site 216432000937 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 216432000938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432000939 putative DNA binding site [nucleotide binding]; other site 216432000940 putative Zn2+ binding site [ion binding]; other site 216432000941 AsnC family; Region: AsnC_trans_reg; pfam01037 216432000942 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 216432000943 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216432000944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432000945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432000946 phosphorylation site [posttranslational modification] 216432000947 dimer interface [polypeptide binding]; other site 216432000948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432000949 ATP binding site [chemical binding]; other site 216432000950 Mg2+ binding site [ion binding]; other site 216432000951 G-X-G motif; other site 216432000952 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216432000953 active site 216432000954 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 216432000955 nucleotide binding site/active site [active] 216432000956 HIT family signature motif; other site 216432000957 catalytic residue [active] 216432000958 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216432000959 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216432000960 catalytic loop [active] 216432000961 iron binding site [ion binding]; other site 216432000962 Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]; Region: COG5038 216432000963 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216432000964 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432000965 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 216432000966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432000967 ABC transporter; Region: ABC_tran_2; pfam12848 216432000968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432000969 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 216432000970 putative active site [active] 216432000971 catalytic triad [active] 216432000972 dimer interface [polypeptide binding]; other site 216432000973 multimer interface [polypeptide binding]; other site 216432000974 Bacterial Ig-like domain; Region: Big_5; pfam13205 216432000975 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 216432000976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432000977 active site 216432000978 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216432000979 glycyl-tRNA synthetase; Provisional; Region: PRK04173 216432000980 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216432000981 motif 1; other site 216432000982 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 216432000983 active site 216432000984 motif 2; other site 216432000985 motif 3; other site 216432000986 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 216432000987 anticodon binding site; other site 216432000988 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 216432000989 active site 216432000990 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432000991 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 216432000992 putative active site [active] 216432000993 putative catalytic site [active] 216432000994 putative DNA binding site [nucleotide binding]; other site 216432000995 putative phosphate binding site [ion binding]; other site 216432000996 metal binding site A [ion binding]; metal-binding site 216432000997 putative AP binding site [nucleotide binding]; other site 216432000998 putative metal binding site B [ion binding]; other site 216432000999 hypothetical protein; Validated; Region: PRK09039 216432001000 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432001001 ligand binding site [chemical binding]; other site 216432001002 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216432001003 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216432001004 active site 216432001005 catalytic tetrad [active] 216432001006 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216432001007 putative active site [active] 216432001008 putative metal binding site [ion binding]; other site 216432001009 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216432001010 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 216432001011 active site 216432001012 nucleophile elbow; other site 216432001013 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216432001014 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432001015 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216432001016 DNA binding site [nucleotide binding] 216432001017 active site 216432001018 LysE type translocator; Region: LysE; cl00565 216432001019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432001020 S-adenosylmethionine binding site [chemical binding]; other site 216432001021 conserved hypothetical protein; Region: MJ1255; TIGR00661 216432001022 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 216432001023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432001024 dimer interface [polypeptide binding]; other site 216432001025 phosphorylation site [posttranslational modification] 216432001026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432001027 ATP binding site [chemical binding]; other site 216432001028 Mg2+ binding site [ion binding]; other site 216432001029 G-X-G motif; other site 216432001030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216432001031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432001032 active site 216432001033 phosphorylation site [posttranslational modification] 216432001034 intermolecular recognition site; other site 216432001035 dimerization interface [polypeptide binding]; other site 216432001036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216432001037 DNA binding site [nucleotide binding] 216432001038 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 216432001039 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 216432001040 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432001041 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432001042 Lamin Tail Domain; Region: LTD; pfam00932 216432001043 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432001044 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 216432001045 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 216432001046 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 216432001047 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216432001048 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216432001049 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216432001050 Uncharacterized conserved protein [Function unknown]; Region: COG1284 216432001051 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 216432001052 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 216432001053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432001054 Coenzyme A binding pocket [chemical binding]; other site 216432001055 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432001056 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432001057 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216432001058 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216432001059 dimer interface [polypeptide binding]; other site 216432001060 ssDNA binding site [nucleotide binding]; other site 216432001061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216432001062 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 216432001063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432001064 ATP binding site [chemical binding]; other site 216432001065 putative Mg++ binding site [ion binding]; other site 216432001066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432001067 nucleotide binding region [chemical binding]; other site 216432001068 ATP-binding site [chemical binding]; other site 216432001069 RQC domain; Region: RQC; pfam09382 216432001070 HRDC domain; Region: HRDC; pfam00570 216432001071 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216432001072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432001073 active site 216432001074 phosphorylation site [posttranslational modification] 216432001075 intermolecular recognition site; other site 216432001076 dimerization interface [polypeptide binding]; other site 216432001077 LytTr DNA-binding domain; Region: LytTR; smart00850 216432001078 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432001079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432001080 binding surface 216432001081 TPR motif; other site 216432001082 Histidine kinase; Region: His_kinase; pfam06580 216432001083 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216432001084 metal ion-dependent adhesion site (MIDAS); other site 216432001085 FOG: CBS domain [General function prediction only]; Region: COG0517 216432001086 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 216432001087 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 216432001088 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 216432001089 dimer interface [polypeptide binding]; other site 216432001090 anticodon binding site; other site 216432001091 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 216432001092 homodimer interface [polypeptide binding]; other site 216432001093 motif 1; other site 216432001094 active site 216432001095 motif 2; other site 216432001096 GAD domain; Region: GAD; pfam02938 216432001097 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216432001098 active site 216432001099 motif 3; other site 216432001100 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 216432001101 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432001102 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 216432001103 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432001104 starch binding outer membrane protein SusD; Region: SusD; cd08977 216432001105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 216432001106 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216432001107 Protein export membrane protein; Region: SecD_SecF; cl14618 216432001108 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216432001109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216432001110 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432001111 Outer membrane efflux protein; Region: OEP; pfam02321 216432001112 Outer membrane efflux protein; Region: OEP; pfam02321 216432001113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216432001114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216432001115 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216432001116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216432001117 substrate binding pocket [chemical binding]; other site 216432001118 chain length determination region; other site 216432001119 substrate-Mg2+ binding site; other site 216432001120 catalytic residues [active] 216432001121 aspartate-rich region 1; other site 216432001122 active site lid residues [active] 216432001123 aspartate-rich region 2; other site 216432001124 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 216432001125 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 216432001126 TPP-binding site [chemical binding]; other site 216432001127 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 216432001128 dimer interface [polypeptide binding]; other site 216432001129 PYR/PP interface [polypeptide binding]; other site 216432001130 TPP binding site [chemical binding]; other site 216432001131 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 216432001132 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216432001133 E3 interaction surface; other site 216432001134 lipoyl attachment site [posttranslational modification]; other site 216432001135 e3 binding domain; Region: E3_binding; pfam02817 216432001136 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216432001137 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 216432001138 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 216432001139 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 216432001140 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 216432001141 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 216432001142 FeoA domain; Region: FeoA; pfam04023 216432001143 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 216432001144 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216432001145 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 216432001146 intersubunit interface [polypeptide binding]; other site 216432001147 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 216432001148 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 216432001149 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216432001150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216432001151 ABC-ATPase subunit interface; other site 216432001152 dimer interface [polypeptide binding]; other site 216432001153 putative PBP binding regions; other site 216432001154 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216432001155 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216432001156 ABC-ATPase subunit interface; other site 216432001157 dimer interface [polypeptide binding]; other site 216432001158 putative PBP binding regions; other site 216432001159 Mitochondrial ATPase inhibitor, IATP; Region: IATP; pfam04568 216432001160 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 216432001161 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 216432001162 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216432001163 dimer interface [polypeptide binding]; other site 216432001164 putative radical transfer pathway; other site 216432001165 diiron center [ion binding]; other site 216432001166 tyrosyl radical; other site 216432001167 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 216432001168 ATP cone domain; Region: ATP-cone; pfam03477 216432001169 Class I ribonucleotide reductase; Region: RNR_I; cd01679 216432001170 active site 216432001171 dimer interface [polypeptide binding]; other site 216432001172 catalytic residues [active] 216432001173 effector binding site; other site 216432001174 R2 peptide binding site; other site 216432001175 hypothetical protein; Provisional; Region: PRK14686 216432001176 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216432001177 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432001178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432001179 catalytic residue [active] 216432001180 Colicin V production protein; Region: Colicin_V; pfam02674 216432001181 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216432001182 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216432001183 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216432001184 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216432001185 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216432001186 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216432001187 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216432001188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432001189 binding surface 216432001190 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216432001191 TPR motif; other site 216432001192 Bacterial SH3 domain homologues; Region: SH3b; smart00287 216432001193 Oxygen tolerance; Region: BatD; pfam13584 216432001194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432001195 binding surface 216432001196 TPR motif; other site 216432001197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216432001198 metal ion-dependent adhesion site (MIDAS); other site 216432001199 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 216432001200 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 216432001201 metal ion-dependent adhesion site (MIDAS); other site 216432001202 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 216432001203 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216432001204 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216432001205 metal ion-dependent adhesion site (MIDAS); other site 216432001206 MoxR-like ATPases [General function prediction only]; Region: COG0714 216432001207 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 216432001208 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216432001209 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216432001210 active site 216432001211 catalytic tetrad [active] 216432001212 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216432001213 active site 216432001214 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216432001215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432001216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216432001217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216432001218 SdpI/YhfL protein family; Region: SdpI; pfam13630 216432001219 hypothetical protein; Provisional; Region: PRK11820 216432001220 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 216432001221 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 216432001222 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 216432001223 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 216432001224 catalytic site [active] 216432001225 G-X2-G-X-G-K; other site 216432001226 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 216432001227 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 216432001228 active site 216432001229 (T/H)XGH motif; other site 216432001230 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 216432001231 BON domain; Region: BON; pfam04972 216432001232 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432001233 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 216432001234 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216432001235 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 216432001236 Predicted transcriptional regulators [Transcription]; Region: COG1510 216432001237 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 216432001238 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 216432001239 PA/protease or protease-like domain interface [polypeptide binding]; other site 216432001240 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 216432001241 Zn binding site [ion binding]; other site 216432001242 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432001243 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 216432001244 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 216432001245 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 216432001246 dimer interface [polypeptide binding]; other site 216432001247 motif 1; other site 216432001248 active site 216432001249 motif 2; other site 216432001250 motif 3; other site 216432001251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216432001252 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216432001253 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 216432001254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216432001255 putative active site [active] 216432001256 putative metal binding site [ion binding]; other site 216432001257 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 216432001258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 216432001259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432001260 ATP binding site [chemical binding]; other site 216432001261 putative Mg++ binding site [ion binding]; other site 216432001262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432001263 nucleotide binding region [chemical binding]; other site 216432001264 ATP-binding site [chemical binding]; other site 216432001265 DEAD/H associated; Region: DEAD_assoc; pfam08494 216432001266 ATP-dependent DNA ligase; Validated; Region: PRK09247 216432001267 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 216432001268 active site 216432001269 DNA binding site [nucleotide binding] 216432001270 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 216432001271 DNA binding site [nucleotide binding] 216432001272 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 216432001273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 216432001274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432001275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432001276 dimer interface [polypeptide binding]; other site 216432001277 phosphorylation site [posttranslational modification] 216432001278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432001279 ATP binding site [chemical binding]; other site 216432001280 Mg2+ binding site [ion binding]; other site 216432001281 G-X-G motif; other site 216432001282 Response regulator receiver domain; Region: Response_reg; pfam00072 216432001283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432001284 active site 216432001285 phosphorylation site [posttranslational modification] 216432001286 intermolecular recognition site; other site 216432001287 dimerization interface [polypeptide binding]; other site 216432001288 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 216432001289 Rab subfamily motif 1 (RabSF1); other site 216432001290 G1 box; other site 216432001291 GTP/Mg2+ binding site [chemical binding]; other site 216432001292 Rab subfamily motif 2 (RabSF2); other site 216432001293 Switch I region; other site 216432001294 G2 box; other site 216432001295 effector interaction site; other site 216432001296 GDI interaction site; other site 216432001297 Rab family motif 1 (RabF1); other site 216432001298 GEF interaction site [polypeptide binding]; other site 216432001299 Rab family motif 2 (RabF2); other site 216432001300 G3 box; other site 216432001301 Switch II region; other site 216432001302 Rab family motif 3 (RabF3); other site 216432001303 Rab family motif 4 (RabF4); other site 216432001304 Rab family motif 5 (RabF5); other site 216432001305 Rab subfamily motif 3 (RabSF3); other site 216432001306 G4 box; other site 216432001307 G5 box; other site 216432001308 Hepatic lectin, N-terminal domain; Region: Lectin_N; pfam03954 216432001309 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 216432001310 AMP binding site [chemical binding]; other site 216432001311 metal binding site [ion binding]; metal-binding site 216432001312 active site 216432001313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432001314 Coenzyme A binding pocket [chemical binding]; other site 216432001315 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 216432001316 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 216432001317 nucleotide binding site [chemical binding]; other site 216432001318 substrate binding site [chemical binding]; other site 216432001319 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 216432001320 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216432001321 putative acyl-acceptor binding pocket; other site 216432001322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 216432001323 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 216432001324 Lumazine binding domain; Region: Lum_binding; pfam00677 216432001325 Lumazine binding domain; Region: Lum_binding; pfam00677 216432001326 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 216432001327 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 216432001328 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 216432001329 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 216432001330 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216432001331 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216432001332 dimer interface [polypeptide binding]; other site 216432001333 active site 216432001334 CoA binding pocket [chemical binding]; other site 216432001335 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 216432001336 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216432001337 carboxyltransferase (CT) interaction site; other site 216432001338 biotinylation site [posttranslational modification]; other site 216432001339 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216432001340 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216432001341 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216432001342 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216432001343 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216432001344 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216432001345 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 216432001346 Transglycosylase; Region: Transgly; cl17702 216432001347 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 216432001348 mismatch recognition site; other site 216432001349 additional DNA contacts [nucleotide binding]; other site 216432001350 active site 216432001351 zinc binding site [ion binding]; other site 216432001352 DNA intercalation site [nucleotide binding]; other site 216432001353 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216432001354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432001355 Walker A/P-loop; other site 216432001356 ATP binding site [chemical binding]; other site 216432001357 Q-loop/lid; other site 216432001358 ABC transporter signature motif; other site 216432001359 Walker B; other site 216432001360 D-loop; other site 216432001361 H-loop/switch region; other site 216432001362 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 216432001363 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216432001364 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 216432001365 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216432001366 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 216432001367 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 216432001368 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 216432001369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 216432001370 active site 216432001371 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216432001372 dimer interface [polypeptide binding]; other site 216432001373 substrate binding site [chemical binding]; other site 216432001374 catalytic residues [active] 216432001375 thymidine kinase; Provisional; Region: PRK04296 216432001376 DoxX-like family; Region: DoxX_2; pfam13564 216432001377 Predicted methyltransferases [General function prediction only]; Region: COG0313 216432001378 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 216432001379 putative SAM binding site [chemical binding]; other site 216432001380 putative homodimer interface [polypeptide binding]; other site 216432001381 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 216432001382 Peptidase family M1; Region: Peptidase_M1; pfam01433 216432001383 Zn binding site [ion binding]; other site 216432001384 aldehyde dehydrogenase family 7 member; Region: PLN02315 216432001385 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 216432001386 tetrameric interface [polypeptide binding]; other site 216432001387 NAD binding site [chemical binding]; other site 216432001388 catalytic residues [active] 216432001389 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 216432001390 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 216432001391 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216432001392 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 216432001393 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 216432001394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216432001395 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 216432001396 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 216432001397 putative active site [active] 216432001398 Zn binding site [ion binding]; other site 216432001399 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 216432001400 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 216432001401 lipoprotein signal peptidase; Provisional; Region: PRK14788 216432001402 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 216432001403 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 216432001404 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432001405 active site 216432001406 HIGH motif; other site 216432001407 nucleotide binding site [chemical binding]; other site 216432001408 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432001409 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432001410 active site 216432001411 KMSKS motif; other site 216432001412 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 216432001413 tRNA binding surface [nucleotide binding]; other site 216432001414 anticodon binding site; other site 216432001415 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432001416 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216432001417 N-terminal plug; other site 216432001418 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216432001419 ligand-binding site [chemical binding]; other site 216432001420 Recombination protein O N terminal; Region: RecO_N; pfam11967 216432001421 Recombination protein O C terminal; Region: RecO_C; pfam02565 216432001422 Protein of unknown function (DUF1191); Region: DUF1191; pfam06697 216432001423 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432001424 glutamate dehydrogenase; Provisional; Region: PRK09414 216432001425 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216432001426 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 216432001427 NAD(P) binding site [chemical binding]; other site 216432001428 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 216432001429 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216432001430 homodimer interface [polypeptide binding]; other site 216432001431 substrate-cofactor binding pocket; other site 216432001432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432001433 catalytic residue [active] 216432001434 DinB superfamily; Region: DinB_2; pfam12867 216432001435 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216432001436 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216432001437 EamA-like transporter family; Region: EamA; pfam00892 216432001438 EamA-like transporter family; Region: EamA; pfam00892 216432001439 SnoaL-like domain; Region: SnoaL_2; pfam12680 216432001440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 216432001441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216432001442 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 216432001443 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 216432001444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432001445 ATP binding site [chemical binding]; other site 216432001446 putative Mg++ binding site [ion binding]; other site 216432001447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432001448 nucleotide binding region [chemical binding]; other site 216432001449 ATP-binding site [chemical binding]; other site 216432001450 TRCF domain; Region: TRCF; pfam03461 216432001451 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 216432001452 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 216432001453 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 216432001454 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216432001455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216432001456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432001457 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216432001458 DNA polymerase I; Provisional; Region: PRK05755 216432001459 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216432001460 active site 216432001461 metal binding site 1 [ion binding]; metal-binding site 216432001462 putative 5' ssDNA interaction site; other site 216432001463 metal binding site 3; metal-binding site 216432001464 metal binding site 2 [ion binding]; metal-binding site 216432001465 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216432001466 putative DNA binding site [nucleotide binding]; other site 216432001467 putative metal binding site [ion binding]; other site 216432001468 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 216432001469 active site 216432001470 catalytic site [active] 216432001471 substrate binding site [chemical binding]; other site 216432001472 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 216432001473 active site 216432001474 DNA binding site [nucleotide binding] 216432001475 catalytic site [active] 216432001476 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 216432001477 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 216432001478 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 216432001479 dimer interface [polypeptide binding]; other site 216432001480 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 216432001481 active site 216432001482 Fe binding site [ion binding]; other site 216432001483 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 216432001484 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 216432001485 putative peptidase; Provisional; Region: PRK11649 216432001486 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432001487 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432001488 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432001489 catalytic residues [active] 216432001490 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216432001491 putative catalytic site [active] 216432001492 putative metal binding site [ion binding]; other site 216432001493 putative phosphate binding site [ion binding]; other site 216432001494 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432001495 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432001496 EamA-like transporter family; Region: EamA; pfam00892 216432001497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216432001498 EamA-like transporter family; Region: EamA; pfam00892 216432001499 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 216432001500 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 216432001501 gliding motility-associated protein GldE; Region: GldE; TIGR03520 216432001502 Domain of unknown function DUF21; Region: DUF21; pfam01595 216432001503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216432001504 Transporter associated domain; Region: CorC_HlyC; smart01091 216432001505 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216432001506 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216432001507 dimer interface [polypeptide binding]; other site 216432001508 ssDNA binding site [nucleotide binding]; other site 216432001509 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216432001510 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 216432001511 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216432001512 minor groove reading motif; other site 216432001513 helix-hairpin-helix signature motif; other site 216432001514 substrate binding pocket [chemical binding]; other site 216432001515 active site 216432001516 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 216432001517 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 216432001518 DNA binding and oxoG recognition site [nucleotide binding] 216432001519 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216432001520 IHF - DNA interface [nucleotide binding]; other site 216432001521 IHF dimer interface [polypeptide binding]; other site 216432001522 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 216432001523 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216432001524 homodimer interface [polypeptide binding]; other site 216432001525 oligonucleotide binding site [chemical binding]; other site 216432001526 recombination regulator RecX; Reviewed; Region: recX; PRK00117 216432001527 Cupin-like domain; Region: Cupin_8; pfam13621 216432001528 biotin synthase; Region: bioB; TIGR00433 216432001529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432001530 FeS/SAM binding site; other site 216432001531 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 216432001532 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216432001533 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216432001534 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216432001535 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216432001536 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216432001537 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216432001538 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216432001539 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 216432001540 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 216432001541 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 216432001542 Uncharacterized conserved protein [Function unknown]; Region: COG3743 216432001543 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 216432001544 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 216432001545 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 216432001546 putative dimer interface [polypeptide binding]; other site 216432001547 putative anticodon binding site; other site 216432001548 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 216432001549 homodimer interface [polypeptide binding]; other site 216432001550 motif 1; other site 216432001551 motif 2; other site 216432001552 active site 216432001553 motif 3; other site 216432001554 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216432001555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216432001556 RNA binding surface [nucleotide binding]; other site 216432001557 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216432001558 active site 216432001559 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 216432001560 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 216432001561 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 216432001562 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 216432001563 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432001564 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 216432001565 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 216432001566 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216432001567 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 216432001568 active site 216432001569 homodimer interface [polypeptide binding]; other site 216432001570 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216432001571 active site 216432001572 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 216432001573 catalytic motif [active] 216432001574 Catalytic residue [active] 216432001575 YCII-related domain; Region: YCII; cl00999 216432001576 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 216432001577 putative active site [active] 216432001578 putative metal binding residues [ion binding]; other site 216432001579 signature motif; other site 216432001580 putative dimer interface [polypeptide binding]; other site 216432001581 putative phosphate binding site [ion binding]; other site 216432001582 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 216432001583 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216432001584 NAD binding site [chemical binding]; other site 216432001585 active site 216432001586 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216432001587 active site 216432001588 DNA polymerase IV; Validated; Region: PRK02406 216432001589 DNA binding site [nucleotide binding] 216432001590 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216432001591 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 216432001592 DHH family; Region: DHH; pfam01368 216432001593 DHHA1 domain; Region: DHHA1; pfam02272 216432001594 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 216432001595 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086 216432001596 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216432001597 putative active site [active] 216432001598 putative metal binding site [ion binding]; other site 216432001599 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 216432001600 active site 216432001601 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 216432001602 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 216432001603 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 216432001604 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 216432001605 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432001606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432001607 S-adenosylmethionine binding site [chemical binding]; other site 216432001608 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 216432001609 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 216432001610 Substrate binding site; other site 216432001611 metal-binding site 216432001612 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216432001613 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 216432001614 Probable Catalytic site; other site 216432001615 metal-binding site 216432001616 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 216432001617 putative ADP-binding pocket [chemical binding]; other site 216432001618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432001619 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216432001620 Ligand Binding Site [chemical binding]; other site 216432001621 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 216432001622 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216432001623 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432001624 GH3 auxin-responsive promoter; Region: GH3; pfam03321 216432001625 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 216432001626 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 216432001627 NADP-binding site; other site 216432001628 homotetramer interface [polypeptide binding]; other site 216432001629 substrate binding site [chemical binding]; other site 216432001630 homodimer interface [polypeptide binding]; other site 216432001631 active site 216432001632 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 216432001633 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 216432001634 NADP binding site [chemical binding]; other site 216432001635 active site 216432001636 putative substrate binding site [chemical binding]; other site 216432001637 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 216432001638 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216432001639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216432001640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432001641 O-Antigen ligase; Region: Wzy_C; pfam04932 216432001642 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432001643 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216432001644 putative acyl transferase; Provisional; Region: PRK10502 216432001645 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 216432001646 putative trimer interface [polypeptide binding]; other site 216432001647 putative active site [active] 216432001648 putative substrate binding site [chemical binding]; other site 216432001649 putative CoA binding site [chemical binding]; other site 216432001650 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 216432001651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216432001652 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 216432001653 NAD binding site [chemical binding]; other site 216432001654 putative substrate binding site 2 [chemical binding]; other site 216432001655 putative substrate binding site 1 [chemical binding]; other site 216432001656 active site 216432001657 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 216432001658 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216432001659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432001660 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 216432001661 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 216432001662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216432001663 acyl-activating enzyme (AAE) consensus motif; other site 216432001664 active site 216432001665 AMP binding site [chemical binding]; other site 216432001666 CoA binding site [chemical binding]; other site 216432001667 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 216432001668 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 216432001669 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 216432001670 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 216432001671 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 216432001672 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216432001673 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216432001674 putative active site [active] 216432001675 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 216432001676 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 216432001677 FAD binding pocket [chemical binding]; other site 216432001678 FAD binding motif [chemical binding]; other site 216432001679 phosphate binding motif [ion binding]; other site 216432001680 beta-alpha-beta structure motif; other site 216432001681 NAD(p) ribose binding residues [chemical binding]; other site 216432001682 NAD binding pocket [chemical binding]; other site 216432001683 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 216432001684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216432001685 catalytic loop [active] 216432001686 iron binding site [ion binding]; other site 216432001687 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216432001688 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216432001689 Walker A/P-loop; other site 216432001690 ATP binding site [chemical binding]; other site 216432001691 Q-loop/lid; other site 216432001692 ABC transporter signature motif; other site 216432001693 Walker B; other site 216432001694 D-loop; other site 216432001695 H-loop/switch region; other site 216432001696 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 216432001697 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 216432001698 ATP synthase A chain; Region: ATP-synt_A; cl00413 216432001699 ATP synthase subunit C; Region: ATP-synt_C; cl00466 216432001700 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471 216432001701 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 216432001702 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 216432001703 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 216432001704 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 216432001705 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216432001706 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 216432001707 beta subunit interaction interface [polypeptide binding]; other site 216432001708 Walker A motif; other site 216432001709 ATP binding site [chemical binding]; other site 216432001710 Walker B motif; other site 216432001711 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216432001712 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 216432001713 core domain interface [polypeptide binding]; other site 216432001714 delta subunit interface [polypeptide binding]; other site 216432001715 epsilon subunit interface [polypeptide binding]; other site 216432001716 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432001717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216432001718 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216432001719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216432001720 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 216432001721 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 216432001722 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 216432001723 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216432001724 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216432001725 protein binding site [polypeptide binding]; other site 216432001726 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216432001727 Catalytic dyad [active] 216432001728 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 216432001729 ribonuclease P; Reviewed; Region: rnpA; PRK01903 216432001730 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 216432001731 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 216432001732 domain interfaces; other site 216432001733 active site 216432001734 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 216432001735 dimerization interface [polypeptide binding]; other site 216432001736 active site 216432001737 metal binding site [ion binding]; metal-binding site 216432001738 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 216432001739 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 216432001740 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216432001741 dimer interface [polypeptide binding]; other site 216432001742 active site 216432001743 acyl carrier protein; Provisional; Region: acpP; PRK00982 216432001744 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 216432001745 active site 216432001746 cosubstrate binding site; other site 216432001747 substrate binding site [chemical binding]; other site 216432001748 catalytic site [active] 216432001749 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 216432001750 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 216432001751 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 216432001752 RNA/DNA hybrid binding site [nucleotide binding]; other site 216432001753 active site 216432001754 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216432001755 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 216432001756 substrate binding site [chemical binding]; other site 216432001757 ATP binding site [chemical binding]; other site 216432001758 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 216432001759 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 216432001760 active site 216432001761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432001762 active site 216432001763 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 216432001764 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216432001765 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216432001766 putative recombination protein RecB; Provisional; Region: PRK13909 216432001767 Family description; Region: UvrD_C_2; pfam13538 216432001768 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216432001769 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 216432001770 substrate-cofactor binding pocket; other site 216432001771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432001772 catalytic residue [active] 216432001773 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 216432001774 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432001775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432001776 ligand binding site [chemical binding]; other site 216432001777 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 216432001778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216432001779 NlpE N-terminal domain; Region: NlpE; pfam04170 216432001780 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 216432001781 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216432001782 FMN binding site [chemical binding]; other site 216432001783 active site 216432001784 catalytic residues [active] 216432001785 substrate binding site [chemical binding]; other site 216432001786 GTP-binding protein LepA; Provisional; Region: PRK05433 216432001787 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 216432001788 putative GEF interaction site [polypeptide binding]; other site 216432001789 Switch I region; other site 216432001790 G2 box; other site 216432001791 G3 box; other site 216432001792 Switch II region; other site 216432001793 GTP/Mg2+ binding site [chemical binding]; other site 216432001794 G4 box; other site 216432001795 G5 box; other site 216432001796 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 216432001797 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 216432001798 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 216432001799 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 216432001800 TrkA-N domain; Region: TrkA_N; pfam02254 216432001801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216432001802 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 216432001803 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 216432001804 active site 216432001805 catalytic triad [active] 216432001806 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 216432001807 Zn binding site [ion binding]; other site 216432001808 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432001809 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 216432001810 putative uracil binding site [chemical binding]; other site 216432001811 putative active site [active] 216432001812 acetyl-CoA synthetase; Provisional; Region: PRK00174 216432001813 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 216432001814 active site 216432001815 CoA binding site [chemical binding]; other site 216432001816 acyl-activating enzyme (AAE) consensus motif; other site 216432001817 AMP binding site [chemical binding]; other site 216432001818 acetate binding site [chemical binding]; other site 216432001819 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216432001820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216432001821 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432001822 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216432001823 Interdomain contacts; other site 216432001824 Cytokine receptor motif; other site 216432001825 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432001826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216432001827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432001828 active site 216432001829 phosphorylation site [posttranslational modification] 216432001830 intermolecular recognition site; other site 216432001831 dimerization interface [polypeptide binding]; other site 216432001832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216432001833 DNA binding site [nucleotide binding] 216432001834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432001835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432001836 dimer interface [polypeptide binding]; other site 216432001837 phosphorylation site [posttranslational modification] 216432001838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432001839 ATP binding site [chemical binding]; other site 216432001840 Mg2+ binding site [ion binding]; other site 216432001841 G-X-G motif; other site 216432001842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216432001843 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 216432001844 dimer interface [polypeptide binding]; other site 216432001845 substrate binding site [chemical binding]; other site 216432001846 metal binding site [ion binding]; metal-binding site 216432001847 Ribosome-binding factor A; Region: RBFA; pfam02033 216432001848 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 216432001849 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216432001850 FtsX-like permease family; Region: FtsX; pfam02687 216432001851 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 216432001852 putative S-transferase; Provisional; Region: PRK11752 216432001853 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216432001854 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216432001855 catalytic residue [active] 216432001856 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432001857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216432001858 Phosphoglycerate kinase; Region: PGK; pfam00162 216432001859 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 216432001860 substrate binding site [chemical binding]; other site 216432001861 hinge regions; other site 216432001862 ADP binding site [chemical binding]; other site 216432001863 catalytic site [active] 216432001864 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 216432001865 DNA polymerase III subunit delta'; Validated; Region: PRK08485 216432001866 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 216432001867 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216432001868 FAD binding domain; Region: FAD_binding_4; pfam01565 216432001869 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216432001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432001871 NAD(P) binding site [chemical binding]; other site 216432001872 active site 216432001873 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216432001874 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 216432001875 periplasmic chaperone; Provisional; Region: PRK10780 216432001876 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432001877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432001878 S-adenosylmethionine binding site [chemical binding]; other site 216432001879 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 216432001880 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 216432001881 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 216432001882 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 216432001883 CobD/Cbib protein; Region: CobD_Cbib; cl00561 216432001884 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 216432001885 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216432001886 HIGH motif; other site 216432001887 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216432001888 active site 216432001889 KMSKS motif; other site 216432001890 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432001891 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216432001892 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 216432001893 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 216432001894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432001895 Walker A/P-loop; other site 216432001896 ATP binding site [chemical binding]; other site 216432001897 Q-loop/lid; other site 216432001898 ABC transporter signature motif; other site 216432001899 Walker B; other site 216432001900 D-loop; other site 216432001901 H-loop/switch region; other site 216432001902 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 216432001903 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432001904 active site 216432001905 HIGH motif; other site 216432001906 nucleotide binding site [chemical binding]; other site 216432001907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432001908 active site 216432001909 KMSKS motif; other site 216432001910 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 216432001911 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 216432001912 active site 216432001913 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 216432001914 LysE type translocator; Region: LysE; cl00565 216432001915 ribonuclease R; Region: RNase_R; TIGR02063 216432001916 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 216432001917 RNB domain; Region: RNB; pfam00773 216432001918 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 216432001919 RNA binding site [nucleotide binding]; other site 216432001920 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 216432001921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216432001922 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216432001923 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216432001924 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 216432001925 Transglycosylase; Region: Transgly; pfam00912 216432001926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216432001927 GldH lipoprotein; Region: GldH_lipo; pfam14109 216432001928 PSP1 C-terminal conserved region; Region: PSP1; cl00770 216432001929 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 216432001930 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 216432001931 active site residue [active] 216432001932 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 216432001933 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 216432001934 hexamer interface [polypeptide binding]; other site 216432001935 Walker A motif; other site 216432001936 ATP binding site [chemical binding]; other site 216432001937 Walker B motif; other site 216432001938 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216432001939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432001940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432001941 DNA binding residues [nucleotide binding] 216432001942 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216432001943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216432001944 putative acyl-acceptor binding pocket; other site 216432001945 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 216432001946 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 216432001947 active site 216432001948 HIGH motif; other site 216432001949 dimer interface [polypeptide binding]; other site 216432001950 KMSKS motif; other site 216432001951 DNA protecting protein DprA; Region: dprA; TIGR00732 216432001952 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 216432001953 Sporulation related domain; Region: SPOR; pfam05036 216432001954 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 216432001955 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 216432001956 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432001957 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 216432001958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432001959 TPR motif; other site 216432001960 binding surface 216432001961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432001962 binding surface 216432001963 TPR motif; other site 216432001964 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 216432001965 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 216432001966 active site 216432001967 Substrate binding site; other site 216432001968 Mg++ binding site; other site 216432001969 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216432001970 putative trimer interface [polypeptide binding]; other site 216432001971 putative CoA binding site [chemical binding]; other site 216432001972 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216432001973 trimer interface [polypeptide binding]; other site 216432001974 active site 216432001975 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216432001976 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216432001977 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216432001978 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216432001979 Walker A/P-loop; other site 216432001980 ATP binding site [chemical binding]; other site 216432001981 Q-loop/lid; other site 216432001982 ABC transporter signature motif; other site 216432001983 Walker B; other site 216432001984 D-loop; other site 216432001985 H-loop/switch region; other site 216432001986 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216432001987 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216432001988 Walker A/P-loop; other site 216432001989 ATP binding site [chemical binding]; other site 216432001990 Q-loop/lid; other site 216432001991 ABC transporter signature motif; other site 216432001992 Walker B; other site 216432001993 D-loop; other site 216432001994 H-loop/switch region; other site 216432001995 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216432001996 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 216432001997 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 216432001998 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 216432001999 active site 216432002000 Zn binding site [ion binding]; other site 216432002001 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216432002002 Interdomain contacts; other site 216432002003 Cytokine receptor motif; other site 216432002004 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 216432002005 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002006 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 216432002007 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 216432002008 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 216432002009 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 216432002010 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 216432002011 active site 216432002012 catalytic site [active] 216432002013 substrate binding site [chemical binding]; other site 216432002014 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432002015 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432002016 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 216432002017 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216432002018 DNA binding site [nucleotide binding] 216432002019 active site 216432002020 Domain of unknown function DUF21; Region: DUF21; pfam01595 216432002021 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216432002022 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 216432002023 nudix motif; other site 216432002024 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 216432002025 dimer interface [polypeptide binding]; other site 216432002026 allosteric magnesium binding site [ion binding]; other site 216432002027 active site 216432002028 aspartate-rich active site metal binding site; other site 216432002029 Schiff base residues; other site 216432002030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216432002031 TPR motif; other site 216432002032 binding surface 216432002033 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 216432002034 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 216432002035 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 216432002036 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 216432002037 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 216432002038 substrate binding site [chemical binding]; other site 216432002039 active site 216432002040 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 216432002041 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 216432002042 active site 216432002043 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 216432002044 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 216432002045 domain interfaces; other site 216432002046 active site 216432002047 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 216432002048 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 216432002049 tRNA; other site 216432002050 putative tRNA binding site [nucleotide binding]; other site 216432002051 putative NADP binding site [chemical binding]; other site 216432002052 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 216432002053 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216432002054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216432002055 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216432002056 ferrochelatase; Reviewed; Region: hemH; PRK00035 216432002057 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 216432002058 C-terminal domain interface [polypeptide binding]; other site 216432002059 active site 216432002060 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 216432002061 active site 216432002062 N-terminal domain interface [polypeptide binding]; other site 216432002063 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 216432002064 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 216432002065 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 216432002066 Asp-box motif; other site 216432002067 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 216432002068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432002069 HAMP domain; Region: HAMP; pfam00672 216432002070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432002071 dimer interface [polypeptide binding]; other site 216432002072 phosphorylation site [posttranslational modification] 216432002073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432002074 ATP binding site [chemical binding]; other site 216432002075 Mg2+ binding site [ion binding]; other site 216432002076 G-X-G motif; other site 216432002077 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 216432002078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216432002079 substrate binding site [chemical binding]; other site 216432002080 oxyanion hole (OAH) forming residues; other site 216432002081 trimer interface [polypeptide binding]; other site 216432002082 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 216432002083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432002084 FeS/SAM binding site; other site 216432002085 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 216432002086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432002087 Zn2+ binding site [ion binding]; other site 216432002088 Mg2+ binding site [ion binding]; other site 216432002089 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 216432002090 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 216432002091 homodimer interface [polypeptide binding]; other site 216432002092 putative substrate binding pocket [chemical binding]; other site 216432002093 diiron center [ion binding]; other site 216432002094 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216432002095 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216432002096 putative acyl-acceptor binding pocket; other site 216432002097 Disulphide isomerase; Region: Disulph_isomer; pfam06491 216432002098 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 216432002099 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 216432002100 putative metal binding site [ion binding]; other site 216432002101 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216432002102 HSP70 interaction site [polypeptide binding]; other site 216432002103 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 216432002104 catalytic nucleophile [active] 216432002105 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 216432002106 active site 216432002107 metal binding site [ion binding]; metal-binding site 216432002108 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 216432002109 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216432002110 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 216432002111 putative ligand binding site [chemical binding]; other site 216432002112 putative NAD binding site [chemical binding]; other site 216432002113 catalytic site [active] 216432002114 Cupin domain; Region: Cupin_2; cl17218 216432002115 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216432002116 active site 216432002117 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 216432002118 MgtE intracellular N domain; Region: MgtE_N; pfam03448 216432002119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 216432002120 Divalent cation transporter; Region: MgtE; pfam01769 216432002121 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 216432002122 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 216432002123 S-adenosylmethionine binding site [chemical binding]; other site 216432002124 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 216432002125 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216432002126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432002127 binding surface 216432002128 TPR motif; other site 216432002129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 216432002130 seryl-tRNA synthetase; Provisional; Region: PRK05431 216432002131 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 216432002132 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 216432002133 dimer interface [polypeptide binding]; other site 216432002134 active site 216432002135 motif 1; other site 216432002136 motif 2; other site 216432002137 motif 3; other site 216432002138 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 216432002139 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 216432002140 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 216432002141 homotetramer interface [polypeptide binding]; other site 216432002142 ligand binding site [chemical binding]; other site 216432002143 catalytic site [active] 216432002144 NAD binding site [chemical binding]; other site 216432002145 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 216432002146 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 216432002147 PcrB family; Region: PcrB; pfam01884 216432002148 phosphate binding site [ion binding]; other site 216432002149 Family of unknown function (DUF490); Region: DUF490; pfam04357 216432002150 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432002151 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 216432002152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216432002153 acyl-activating enzyme (AAE) consensus motif; other site 216432002154 AMP binding site [chemical binding]; other site 216432002155 active site 216432002156 CoA binding site [chemical binding]; other site 216432002157 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 216432002158 Cupin-like domain; Region: Cupin_8; pfam13621 216432002159 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216432002160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216432002161 Predicted exporter [General function prediction only]; Region: COG4258 216432002162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216432002163 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216432002164 putative acyl-acceptor binding pocket; other site 216432002165 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216432002166 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216432002167 Ligand binding site; other site 216432002168 Putative Catalytic site; other site 216432002169 DXD motif; other site 216432002170 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 216432002171 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 216432002172 active site 2 [active] 216432002173 dimer interface [polypeptide binding]; other site 216432002174 active site 1 [active] 216432002175 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 216432002176 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216432002177 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 216432002178 NodB motif; other site 216432002179 active site 216432002180 catalytic site [active] 216432002181 metal binding site [ion binding]; metal-binding site 216432002182 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216432002183 active site 216432002184 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216432002185 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216432002186 dimer interface [polypeptide binding]; other site 216432002187 active site 216432002188 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216432002189 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216432002190 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216432002191 active site 216432002192 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216432002193 active site 216432002194 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216432002195 active site 2 [active] 216432002196 active site 1 [active] 216432002197 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216432002198 putative acyl-acceptor binding pocket; other site 216432002199 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216432002200 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216432002201 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216432002202 dimer interface [polypeptide binding]; other site 216432002203 active site 216432002204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216432002205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432002206 NAD(P) binding site [chemical binding]; other site 216432002207 active site 216432002208 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216432002209 active sites [active] 216432002210 tetramer interface [polypeptide binding]; other site 216432002211 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 216432002212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216432002213 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 216432002214 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 216432002215 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 216432002216 NAD binding site [chemical binding]; other site 216432002217 homodimer interface [polypeptide binding]; other site 216432002218 active site 216432002219 substrate binding site [chemical binding]; other site 216432002220 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 216432002221 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 216432002222 active site 216432002223 Zn binding site [ion binding]; other site 216432002224 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 216432002225 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216432002226 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 216432002227 active site 216432002228 DNA binding site [nucleotide binding] 216432002229 Int/Topo IB signature motif; other site 216432002230 Helix-turn-helix domain; Region: HTH_17; pfam12728 216432002231 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 216432002232 non-specific DNA interactions [nucleotide binding]; other site 216432002233 DNA binding site [nucleotide binding] 216432002234 sequence specific DNA binding site [nucleotide binding]; other site 216432002235 putative cAMP binding site [chemical binding]; other site 216432002236 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 216432002237 RIP metalloprotease RseP; Region: TIGR00054 216432002238 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216432002239 active site 216432002240 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 216432002241 protein binding site [polypeptide binding]; other site 216432002242 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216432002243 putative substrate binding region [chemical binding]; other site 216432002244 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 216432002245 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 216432002246 Cu(I) binding site [ion binding]; other site 216432002247 FeoA domain; Region: FeoA; pfam04023 216432002248 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 216432002249 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 216432002250 G1 box; other site 216432002251 GTP/Mg2+ binding site [chemical binding]; other site 216432002252 Switch I region; other site 216432002253 G2 box; other site 216432002254 G3 box; other site 216432002255 Switch II region; other site 216432002256 G4 box; other site 216432002257 G5 box; other site 216432002258 Nucleoside recognition; Region: Gate; pfam07670 216432002259 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 216432002260 Nucleoside recognition; Region: Gate; pfam07670 216432002261 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216432002262 C-terminal peptidase (prc); Region: prc; TIGR00225 216432002263 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216432002264 protein binding site [polypeptide binding]; other site 216432002265 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216432002266 Catalytic dyad [active] 216432002267 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 216432002268 catalytic motif [active] 216432002269 Zn binding site [ion binding]; other site 216432002270 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 216432002271 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 216432002272 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 216432002273 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432002274 active site 216432002275 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 216432002276 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 216432002277 5S rRNA interface [nucleotide binding]; other site 216432002278 CTC domain interface [polypeptide binding]; other site 216432002279 L16 interface [polypeptide binding]; other site 216432002280 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 216432002281 putative active site [active] 216432002282 catalytic residue [active] 216432002283 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 216432002284 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 216432002285 active site 216432002286 Riboflavin kinase; Region: Flavokinase; pfam01687 216432002287 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 216432002288 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 216432002289 Protein export membrane protein; Region: SecD_SecF; cl14618 216432002290 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432002291 ribosome recycling factor; Reviewed; Region: frr; PRK00083 216432002292 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 216432002293 hinge region; other site 216432002294 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 216432002295 putative nucleotide binding site [chemical binding]; other site 216432002296 uridine monophosphate binding site [chemical binding]; other site 216432002297 homohexameric interface [polypeptide binding]; other site 216432002298 Spondin_N; Region: Spond_N; pfam06468 216432002299 elongation factor Ts; Provisional; Region: tsf; PRK09377 216432002300 UBA/TS-N domain; Region: UBA; pfam00627 216432002301 Elongation factor TS; Region: EF_TS; pfam00889 216432002302 Elongation factor TS; Region: EF_TS; pfam00889 216432002303 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 216432002304 rRNA interaction site [nucleotide binding]; other site 216432002305 S8 interaction site; other site 216432002306 putative laminin-1 binding site; other site 216432002307 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 216432002308 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 216432002309 23S rRNA interface [nucleotide binding]; other site 216432002310 L3 interface [polypeptide binding]; other site 216432002311 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432002312 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432002313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432002314 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 216432002315 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002316 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 216432002317 putative ligand binding site [chemical binding]; other site 216432002318 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 216432002319 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 216432002320 putative active site [active] 216432002321 Zn binding site [ion binding]; other site 216432002322 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 216432002323 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 216432002324 active site 216432002325 HIGH motif; other site 216432002326 KMSKS motif; other site 216432002327 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 216432002328 tRNA binding surface [nucleotide binding]; other site 216432002329 anticodon binding site; other site 216432002330 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 216432002331 dimer interface [polypeptide binding]; other site 216432002332 putative tRNA-binding site [nucleotide binding]; other site 216432002333 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 216432002334 dimer interface [polypeptide binding]; other site 216432002335 catalytic triad [active] 216432002336 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 216432002337 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 216432002338 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216432002339 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 216432002340 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 216432002341 PA/protease or protease-like domain interface [polypeptide binding]; other site 216432002342 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 216432002343 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 216432002344 Zn binding site [ion binding]; other site 216432002345 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002346 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 216432002347 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 216432002348 PA/protease or protease-like domain interface [polypeptide binding]; other site 216432002349 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 216432002350 Zn binding site [ion binding]; other site 216432002351 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002352 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 216432002353 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 216432002354 TPP-binding site; other site 216432002355 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216432002356 PYR/PP interface [polypeptide binding]; other site 216432002357 dimer interface [polypeptide binding]; other site 216432002358 TPP binding site [chemical binding]; other site 216432002359 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216432002360 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216432002361 nucleoside/Zn binding site; other site 216432002362 dimer interface [polypeptide binding]; other site 216432002363 catalytic motif [active] 216432002364 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 216432002365 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 216432002366 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432002367 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 216432002368 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432002369 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 216432002370 starch binding outer membrane protein SusD; Region: SusD; cl17845 216432002371 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 216432002372 Na binding site [ion binding]; other site 216432002373 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 216432002374 active site 216432002375 metal binding site [ion binding]; metal-binding site 216432002376 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216432002377 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 216432002378 homodimer interface [polypeptide binding]; other site 216432002379 catalytic residues [active] 216432002380 NAD binding site [chemical binding]; other site 216432002381 substrate binding pocket [chemical binding]; other site 216432002382 flexible flap; other site 216432002383 SurA N-terminal domain; Region: SurA_N_3; cl07813 216432002384 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 216432002385 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 216432002386 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216432002387 Domain of unknown function DUF21; Region: DUF21; pfam01595 216432002388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216432002389 Transporter associated domain; Region: CorC_HlyC; smart01091 216432002390 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 216432002391 TPR repeat; Region: TPR_11; pfam13414 216432002392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432002393 binding surface 216432002394 TPR motif; other site 216432002395 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 216432002396 pantothenate kinase; Reviewed; Region: PRK13320 216432002397 multiple promoter invertase; Provisional; Region: mpi; PRK13413 216432002398 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216432002399 catalytic residues [active] 216432002400 catalytic nucleophile [active] 216432002401 Presynaptic Site I dimer interface [polypeptide binding]; other site 216432002402 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216432002403 Synaptic Flat tetramer interface [polypeptide binding]; other site 216432002404 Synaptic Site I dimer interface [polypeptide binding]; other site 216432002405 DNA binding site [nucleotide binding] 216432002406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432002407 non-specific DNA binding site [nucleotide binding]; other site 216432002408 salt bridge; other site 216432002409 sequence-specific DNA binding site [nucleotide binding]; other site 216432002410 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216432002411 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 216432002412 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 216432002413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216432002414 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 216432002415 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 216432002416 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 216432002417 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216432002418 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216432002419 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432002420 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 216432002421 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 216432002422 catalytic residue [active] 216432002423 putative FPP diphosphate binding site; other site 216432002424 putative FPP binding hydrophobic cleft; other site 216432002425 dimer interface [polypeptide binding]; other site 216432002426 putative IPP diphosphate binding site; other site 216432002427 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432002428 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 216432002429 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 216432002430 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 216432002431 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 216432002432 active site 216432002433 hydrophilic channel; other site 216432002434 dimerization interface [polypeptide binding]; other site 216432002435 catalytic residues [active] 216432002436 active site lid [active] 216432002437 acyl-CoA esterase; Provisional; Region: PRK10673 216432002438 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216432002439 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216432002440 catalytic site [active] 216432002441 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 216432002442 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 216432002443 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 216432002444 catalytic triad [active] 216432002445 trigger factor; Region: tig; TIGR00115 216432002446 Clp protease; Region: CLP_protease; pfam00574 216432002447 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216432002448 oligomer interface [polypeptide binding]; other site 216432002449 active site residues [active] 216432002450 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 216432002451 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 216432002452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432002453 Walker A motif; other site 216432002454 ATP binding site [chemical binding]; other site 216432002455 Walker B motif; other site 216432002456 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216432002457 glutamate racemase; Provisional; Region: PRK00865 216432002458 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 216432002459 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 216432002460 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216432002461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432002462 thiamine-monophosphate kinase; Region: thiL; TIGR01379 216432002463 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 216432002464 ATP binding site [chemical binding]; other site 216432002465 dimerization interface [polypeptide binding]; other site 216432002466 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 216432002467 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002468 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 216432002469 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002470 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 216432002471 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 216432002472 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 216432002473 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 216432002474 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 216432002475 putative ABC transporter; Region: ycf24; CHL00085 216432002476 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216432002477 FeS assembly ATPase SufC; Region: sufC; TIGR01978 216432002478 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 216432002479 Walker A/P-loop; other site 216432002480 ATP binding site [chemical binding]; other site 216432002481 Q-loop/lid; other site 216432002482 ABC transporter signature motif; other site 216432002483 Walker B; other site 216432002484 D-loop; other site 216432002485 H-loop/switch region; other site 216432002486 FeS assembly protein SufD; Region: sufD; TIGR01981 216432002487 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 216432002488 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216432002489 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 216432002490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432002491 catalytic residue [active] 216432002492 META domain; Region: META; pfam03724 216432002493 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 216432002494 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 216432002495 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 216432002496 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 216432002497 Protein of unknown function, DUF481; Region: DUF481; cl01213 216432002498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432002499 binding surface 216432002500 TPR repeat; Region: TPR_11; pfam13414 216432002501 TPR motif; other site 216432002502 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216432002503 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 216432002504 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432002505 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432002506 ligand binding site [chemical binding]; other site 216432002507 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 216432002508 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 216432002509 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216432002510 putative catalytic site [active] 216432002511 putative metal binding site [ion binding]; other site 216432002512 putative phosphate binding site [ion binding]; other site 216432002513 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 216432002514 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 216432002515 HflX GTPase family; Region: HflX; cd01878 216432002516 G1 box; other site 216432002517 GTP/Mg2+ binding site [chemical binding]; other site 216432002518 Switch I region; other site 216432002519 G2 box; other site 216432002520 G3 box; other site 216432002521 Switch II region; other site 216432002522 G4 box; other site 216432002523 G5 box; other site 216432002524 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 216432002525 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 216432002526 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 216432002527 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432002528 active site 216432002529 HIGH motif; other site 216432002530 nucleotide binding site [chemical binding]; other site 216432002531 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216432002532 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432002533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432002534 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432002535 active site 216432002536 KMSKS motif; other site 216432002537 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 216432002538 tRNA binding surface [nucleotide binding]; other site 216432002539 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 216432002540 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 216432002541 Bacitracin resistance protein BacA; Region: BacA; pfam02673 216432002542 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 216432002543 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 216432002544 RNA binding site [nucleotide binding]; other site 216432002545 active site 216432002546 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216432002547 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 216432002548 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 216432002549 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 216432002550 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 216432002551 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216432002552 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 216432002553 putative active site [active] 216432002554 catalytic triad [active] 216432002555 putative dimer interface [polypeptide binding]; other site 216432002556 UbiA prenyltransferase family; Region: UbiA; pfam01040 216432002557 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 216432002558 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 216432002559 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 216432002560 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 216432002561 diphosphomevalonate decarboxylase; Region: PLN02407 216432002562 TspO/MBR family; Region: TspO_MBR; pfam03073 216432002563 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 216432002564 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216432002565 active site 216432002566 catalytic site [active] 216432002567 substrate binding site [chemical binding]; other site 216432002568 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 216432002569 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 216432002570 active site 216432002571 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216432002572 generic binding surface I; other site 216432002573 generic binding surface II; other site 216432002574 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 216432002575 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 216432002576 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 216432002577 dinuclear metal binding motif [ion binding]; other site 216432002578 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 216432002579 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 216432002580 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 216432002581 RimM N-terminal domain; Region: RimM; pfam01782 216432002582 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 216432002583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432002584 S-adenosylmethionine binding site [chemical binding]; other site 216432002585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216432002586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216432002587 active site 216432002588 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 216432002589 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216432002590 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 216432002591 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216432002592 GIY-YIG motif/motif A; other site 216432002593 active site 216432002594 catalytic site [active] 216432002595 putative DNA binding site [nucleotide binding]; other site 216432002596 metal binding site [ion binding]; metal-binding site 216432002597 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 216432002598 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 216432002599 DNA binding site [nucleotide binding] 216432002600 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432002601 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 216432002602 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432002603 Divergent AAA domain; Region: AAA_4; pfam04326 216432002604 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 216432002605 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 216432002606 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216432002607 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 216432002608 L-aspartate oxidase; Provisional; Region: PRK06175 216432002609 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216432002610 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 216432002611 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 216432002612 putative Iron-sulfur protein interface [polypeptide binding]; other site 216432002613 proximal heme binding site [chemical binding]; other site 216432002614 distal heme binding site [chemical binding]; other site 216432002615 putative dimer interface [polypeptide binding]; other site 216432002616 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 216432002617 proline aminopeptidase P II; Provisional; Region: PRK10879 216432002618 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 216432002619 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 216432002620 active site 216432002621 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 216432002622 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216432002623 putative NAD(P) binding site [chemical binding]; other site 216432002624 homotetramer interface [polypeptide binding]; other site 216432002625 homodimer interface [polypeptide binding]; other site 216432002626 active site 216432002627 methionine aminotransferase; Validated; Region: PRK09082 216432002628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216432002629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432002630 homodimer interface [polypeptide binding]; other site 216432002631 catalytic residue [active] 216432002632 CARDB; Region: CARDB; pfam07705 216432002633 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216432002634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432002635 NAD(P) binding site [chemical binding]; other site 216432002636 active site 216432002637 DNA polymerase IV; Provisional; Region: PRK02794 216432002638 SnoaL-like domain; Region: SnoaL_3; pfam13474 216432002639 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216432002640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432002641 NAD(P) binding site [chemical binding]; other site 216432002642 active site 216432002643 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 216432002644 Peptidase family M28; Region: Peptidase_M28; pfam04389 216432002645 metal binding site [ion binding]; metal-binding site 216432002646 Yip1 domain; Region: Yip1; pfam04893 216432002647 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 216432002648 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 216432002649 motif 1; other site 216432002650 active site 216432002651 motif 2; other site 216432002652 motif 3; other site 216432002653 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 216432002654 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216432002655 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432002656 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 216432002657 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216432002658 DNA binding residues [nucleotide binding] 216432002659 LemA family; Region: LemA; cl00742 216432002660 Repair protein; Region: Repair_PSII; pfam04536 216432002661 Repair protein; Region: Repair_PSII; pfam04536 216432002662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432002663 S-adenosylmethionine binding site [chemical binding]; other site 216432002664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432002665 Coenzyme A binding pocket [chemical binding]; other site 216432002666 GTP-binding protein Der; Reviewed; Region: PRK00093 216432002667 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 216432002668 G1 box; other site 216432002669 GTP/Mg2+ binding site [chemical binding]; other site 216432002670 Switch I region; other site 216432002671 G2 box; other site 216432002672 Switch II region; other site 216432002673 G3 box; other site 216432002674 G4 box; other site 216432002675 G5 box; other site 216432002676 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 216432002677 G1 box; other site 216432002678 GTP/Mg2+ binding site [chemical binding]; other site 216432002679 Switch I region; other site 216432002680 G2 box; other site 216432002681 G3 box; other site 216432002682 Switch II region; other site 216432002683 G4 box; other site 216432002684 G5 box; other site 216432002685 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 216432002686 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432002687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216432002688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432002689 putative substrate translocation pore; other site 216432002690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432002691 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 216432002692 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 216432002693 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 216432002694 Competence protein; Region: Competence; pfam03772 216432002695 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216432002696 NlpC/P60 family; Region: NLPC_P60; pfam00877 216432002697 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 216432002698 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 216432002699 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 216432002700 C-terminal peptidase (prc); Region: prc; TIGR00225 216432002701 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 216432002702 protein binding site [polypeptide binding]; other site 216432002703 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216432002704 Catalytic dyad [active] 216432002705 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 216432002706 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 216432002707 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216432002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216432002709 dimer interface [polypeptide binding]; other site 216432002710 conserved gate region; other site 216432002711 putative PBP binding loops; other site 216432002712 ABC-ATPase subunit interface; other site 216432002713 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216432002714 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 216432002715 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 216432002716 catalytic center binding site [active] 216432002717 ATP binding site [chemical binding]; other site 216432002718 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 216432002719 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 216432002720 Substrate-binding site [chemical binding]; other site 216432002721 Substrate specificity [chemical binding]; other site 216432002722 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 216432002723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432002724 Walker A/P-loop; other site 216432002725 ATP binding site [chemical binding]; other site 216432002726 Q-loop/lid; other site 216432002727 ABC transporter signature motif; other site 216432002728 Walker B; other site 216432002729 D-loop; other site 216432002730 H-loop/switch region; other site 216432002731 Protein of unknown function (DUF419); Region: DUF419; pfam04237 216432002732 YcxB-like protein; Region: YcxB; pfam14317 216432002733 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 216432002734 Putative cyclase; Region: Cyclase; pfam04199 216432002735 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216432002736 Histidine kinase; Region: His_kinase; pfam06580 216432002737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432002738 Response regulator receiver domain; Region: Response_reg; pfam00072 216432002739 active site 216432002740 phosphorylation site [posttranslational modification] 216432002741 intermolecular recognition site; other site 216432002742 dimerization interface [polypeptide binding]; other site 216432002743 LytTr DNA-binding domain; Region: LytTR; smart00850 216432002744 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 216432002745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432002746 FeS/SAM binding site; other site 216432002747 HemN C-terminal domain; Region: HemN_C; pfam06969 216432002748 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 216432002749 active site 216432002750 putative DNA-binding cleft [nucleotide binding]; other site 216432002751 dimer interface [polypeptide binding]; other site 216432002752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216432002753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432002754 active site 216432002755 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 216432002756 putative FMN binding site [chemical binding]; other site 216432002757 Protein of unknown function DUF58; Region: DUF58; pfam01882 216432002758 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216432002759 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432002760 catalytic residues [active] 216432002761 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 216432002762 flavoprotein, HI0933 family; Region: TIGR00275 216432002763 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 216432002764 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 216432002765 active site 216432002766 catalytic site [active] 216432002767 tyrosine decarboxylase; Region: PLN02880 216432002768 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432002769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432002770 catalytic residue [active] 216432002771 hypothetical protein; Provisional; Region: PRK08201 216432002772 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 216432002773 metal binding site [ion binding]; metal-binding site 216432002774 putative dimer interface [polypeptide binding]; other site 216432002775 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 216432002776 active site 216432002777 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 216432002778 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 216432002779 PhnA protein; Region: PhnA; pfam03831 216432002780 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 216432002781 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 216432002782 Probable Catalytic site; other site 216432002783 Protein of unknown function, DUF547; Region: DUF547; pfam04784 216432002784 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216432002785 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216432002786 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 216432002787 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216432002788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432002789 S-adenosylmethionine binding site [chemical binding]; other site 216432002790 purine nucleoside phosphorylase; Provisional; Region: PRK08202 216432002791 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 216432002792 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432002793 active site residue [active] 216432002794 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 216432002795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432002796 FeS/SAM binding site; other site 216432002797 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 216432002798 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 216432002799 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 216432002800 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216432002801 active site 216432002802 catalytic site [active] 216432002803 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432002804 SusE outer membrane protein; Region: SusE; pfam14292 216432002805 SusE outer membrane protein; Region: SusE; pfam14292 216432002806 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 216432002807 starch binding site [chemical binding]; other site 216432002808 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 216432002809 starch binding site [chemical binding]; other site 216432002810 SusE outer membrane protein; Region: SusE; pfam14292 216432002811 starch binding outer membrane protein SusD; Region: SusD; cl17845 216432002812 SusD family; Region: SusD; pfam07980 216432002813 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 216432002814 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432002815 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 216432002816 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 216432002817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216432002818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216432002819 DNA binding site [nucleotide binding] 216432002820 domain linker motif; other site 216432002821 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216432002822 dimerization interface [polypeptide binding]; other site 216432002823 ligand binding site [chemical binding]; other site 216432002824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432002825 putative substrate translocation pore; other site 216432002826 beta-phosphoglucomutase; Region: bPGM; TIGR01990 216432002827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216432002828 maltose phosphorylase; Provisional; Region: PRK13807 216432002829 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 216432002830 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 216432002831 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 216432002832 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 216432002833 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 216432002834 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216432002835 Ca binding site [ion binding]; other site 216432002836 active site 216432002837 homodimer interface [polypeptide binding]; other site 216432002838 catalytic site [active] 216432002839 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 216432002840 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 216432002841 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 216432002842 glycogen binding site [chemical binding]; other site 216432002843 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216432002844 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 216432002845 active site 216432002846 catalytic site [active] 216432002847 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 216432002848 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216432002849 active site 216432002850 catalytic site [active] 216432002851 6-phosphofructokinase; Provisional; Region: PRK03202 216432002852 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 216432002853 active site 216432002854 ADP/pyrophosphate binding site [chemical binding]; other site 216432002855 dimerization interface [polypeptide binding]; other site 216432002856 allosteric effector site; other site 216432002857 fructose-1,6-bisphosphate binding site; other site 216432002858 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 216432002859 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 216432002860 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216432002861 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 216432002862 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 216432002863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 216432002864 active site 216432002865 dimer interface [polypeptide binding]; other site 216432002866 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 216432002867 dimer interface [polypeptide binding]; other site 216432002868 active site 216432002869 GSCFA family; Region: GSCFA; pfam08885 216432002870 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 216432002871 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 216432002872 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216432002873 CAP-Gly domain; Region: CAP_GLY; cl08315 216432002874 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 216432002875 MutS domain I; Region: MutS_I; pfam01624 216432002876 MutS domain II; Region: MutS_II; pfam05188 216432002877 MutS domain III; Region: MutS_III; pfam05192 216432002878 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 216432002879 Walker A/P-loop; other site 216432002880 ATP binding site [chemical binding]; other site 216432002881 Q-loop/lid; other site 216432002882 ABC transporter signature motif; other site 216432002883 Walker B; other site 216432002884 D-loop; other site 216432002885 H-loop/switch region; other site 216432002886 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 216432002887 periplasmic chaperone; Provisional; Region: PRK10780 216432002888 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216432002889 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216432002890 ATP binding site [chemical binding]; other site 216432002891 Mg++ binding site [ion binding]; other site 216432002892 motif III; other site 216432002893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432002894 nucleotide binding region [chemical binding]; other site 216432002895 ATP-binding site [chemical binding]; other site 216432002896 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 216432002897 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216432002898 tetramer interface [polypeptide binding]; other site 216432002899 TPP-binding site [chemical binding]; other site 216432002900 heterodimer interface [polypeptide binding]; other site 216432002901 phosphorylation loop region [posttranslational modification] 216432002902 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216432002903 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216432002904 alpha subunit interface [polypeptide binding]; other site 216432002905 TPP binding site [chemical binding]; other site 216432002906 heterodimer interface [polypeptide binding]; other site 216432002907 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216432002908 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 216432002909 GIY-YIG motif/motif A; other site 216432002910 putative active site [active] 216432002911 putative metal binding site [ion binding]; other site 216432002912 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 216432002913 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 216432002914 homodimer interface [polypeptide binding]; other site 216432002915 substrate-cofactor binding pocket; other site 216432002916 catalytic residue [active] 216432002917 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216432002918 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216432002919 E3 interaction surface; other site 216432002920 lipoyl attachment site [posttranslational modification]; other site 216432002921 e3 binding domain; Region: E3_binding; pfam02817 216432002922 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216432002923 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216432002924 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216432002925 putative DNA binding site [nucleotide binding]; other site 216432002926 putative Zn2+ binding site [ion binding]; other site 216432002927 AsnC family; Region: AsnC_trans_reg; pfam01037 216432002928 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 216432002929 GIY-YIG motif/motif A; other site 216432002930 putative active site [active] 216432002931 putative metal binding site [ion binding]; other site 216432002932 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 216432002933 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 216432002934 putative trimer interface [polypeptide binding]; other site 216432002935 putative metal binding site [ion binding]; other site 216432002936 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 216432002937 putative active site [active] 216432002938 GIY-YIG motif/motif A; other site 216432002939 putative metal binding site [ion binding]; other site 216432002940 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216432002941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216432002942 substrate binding site [chemical binding]; other site 216432002943 oxyanion hole (OAH) forming residues; other site 216432002944 trimer interface [polypeptide binding]; other site 216432002945 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 216432002946 putative active site [active] 216432002947 GIY-YIG motif/motif A; other site 216432002948 putative metal binding site [ion binding]; other site 216432002949 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 216432002950 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 216432002951 substrate binding site [chemical binding]; other site 216432002952 dimer interface [polypeptide binding]; other site 216432002953 NADP binding site [chemical binding]; other site 216432002954 catalytic residues [active] 216432002955 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 216432002956 substrate binding site [chemical binding]; other site 216432002957 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216432002958 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 216432002959 putative NAD(P) binding site [chemical binding]; other site 216432002960 homodimer interface [polypeptide binding]; other site 216432002961 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 216432002962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216432002963 dimer interface [polypeptide binding]; other site 216432002964 active site 216432002965 Predicted metalloprotease [General function prediction only]; Region: COG2321 216432002966 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 216432002967 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216432002968 CoenzymeA binding site [chemical binding]; other site 216432002969 subunit interaction site [polypeptide binding]; other site 216432002970 PHB binding site; other site 216432002971 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 216432002972 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216432002973 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216432002974 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216432002975 enoyl-CoA hydratase; Provisional; Region: PRK08140 216432002976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216432002977 substrate binding site [chemical binding]; other site 216432002978 oxyanion hole (OAH) forming residues; other site 216432002979 trimer interface [polypeptide binding]; other site 216432002980 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 216432002981 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 216432002982 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 216432002983 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 216432002984 four helix bundle protein; Region: TIGR02436 216432002985 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 216432002986 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 216432002987 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 216432002988 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 216432002989 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 216432002990 FAD binding pocket [chemical binding]; other site 216432002991 FAD binding motif [chemical binding]; other site 216432002992 phosphate binding motif [ion binding]; other site 216432002993 beta-alpha-beta structure motif; other site 216432002994 NAD(p) ribose binding residues [chemical binding]; other site 216432002995 NAD binding pocket [chemical binding]; other site 216432002996 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 216432002997 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216432002998 catalytic loop [active] 216432002999 iron binding site [ion binding]; other site 216432003000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216432003001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216432003002 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 216432003003 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 216432003004 cofactor binding site; other site 216432003005 metal binding site [ion binding]; metal-binding site 216432003006 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 216432003007 Predicted transcriptional regulator [Transcription]; Region: COG3655 216432003008 non-specific DNA binding site [nucleotide binding]; other site 216432003009 salt bridge; other site 216432003010 sequence-specific DNA binding site [nucleotide binding]; other site 216432003011 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 216432003012 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 216432003013 MgtC family; Region: MgtC; pfam02308 216432003014 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 216432003015 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 216432003016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432003017 catalytic residue [active] 216432003018 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 216432003019 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 216432003020 AAA domain; Region: AAA_26; pfam13500 216432003021 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216432003022 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 216432003023 inhibitor-cofactor binding pocket; inhibition site 216432003024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432003025 catalytic residue [active] 216432003026 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216432003027 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216432003028 active site 216432003029 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 216432003030 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216432003031 Ligand binding site; other site 216432003032 Putative Catalytic site; other site 216432003033 DXD motif; other site 216432003034 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 216432003035 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216432003036 DXD motif; other site 216432003037 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 216432003038 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216432003039 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216432003040 substrate binding pocket [chemical binding]; other site 216432003041 chain length determination region; other site 216432003042 substrate-Mg2+ binding site; other site 216432003043 catalytic residues [active] 216432003044 aspartate-rich region 1; other site 216432003045 active site lid residues [active] 216432003046 aspartate-rich region 2; other site 216432003047 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216432003049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432003050 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 216432003051 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216432003052 Substrate binding site; other site 216432003053 Domain of unknown function (DUF955); Region: DUF955; cl01076 216432003054 SprT homologues; Region: SprT; cl01182 216432003055 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216432003056 classical (c) SDRs; Region: SDR_c; cd05233 216432003057 NAD(P) binding site [chemical binding]; other site 216432003058 active site 216432003059 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216432003060 E3 interaction surface; other site 216432003061 lipoyl attachment site [posttranslational modification]; other site 216432003062 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216432003063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216432003064 E3 interaction surface; other site 216432003065 lipoyl attachment site [posttranslational modification]; other site 216432003066 e3 binding domain; Region: E3_binding; pfam02817 216432003067 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216432003068 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 216432003069 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216432003070 tetramer interface [polypeptide binding]; other site 216432003071 TPP-binding site [chemical binding]; other site 216432003072 heterodimer interface [polypeptide binding]; other site 216432003073 phosphorylation loop region [posttranslational modification] 216432003074 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 216432003075 active site 216432003076 catalytic motif [active] 216432003077 Zn binding site [ion binding]; other site 216432003078 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 216432003079 active site 216432003080 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 216432003081 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216432003082 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 216432003083 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216432003084 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216432003085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432003086 Zn2+ binding site [ion binding]; other site 216432003087 Mg2+ binding site [ion binding]; other site 216432003088 PhoD-like phosphatase; Region: PhoD; pfam09423 216432003089 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 216432003090 putative active site [active] 216432003091 putative metal binding site [ion binding]; other site 216432003092 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 216432003093 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003094 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 216432003095 active site 216432003096 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 216432003097 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 216432003098 dimer interface [polypeptide binding]; other site 216432003099 putative anticodon binding site; other site 216432003100 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 216432003101 motif 1; other site 216432003102 active site 216432003103 motif 2; other site 216432003104 motif 3; other site 216432003105 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 216432003106 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 216432003107 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 216432003108 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003109 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 216432003110 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 216432003111 RNA/DNA hybrid binding site [nucleotide binding]; other site 216432003112 active site 216432003113 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 216432003114 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 216432003115 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 216432003116 active site 216432003117 Zn binding site [ion binding]; other site 216432003118 AIR carboxylase; Region: AIRC; pfam00731 216432003119 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 216432003120 ATP-grasp domain; Region: ATP-grasp; pfam02222 216432003121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432003122 active site 216432003123 adenylate kinase; Reviewed; Region: adk; PRK00279 216432003124 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 216432003125 AMP-binding site [chemical binding]; other site 216432003126 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 216432003127 GTPase CgtA; Reviewed; Region: obgE; PRK12299 216432003128 GTP1/OBG; Region: GTP1_OBG; pfam01018 216432003129 Obg GTPase; Region: Obg; cd01898 216432003130 G1 box; other site 216432003131 GTP/Mg2+ binding site [chemical binding]; other site 216432003132 Switch I region; other site 216432003133 G2 box; other site 216432003134 G3 box; other site 216432003135 Switch II region; other site 216432003136 G4 box; other site 216432003137 G5 box; other site 216432003138 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003139 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 216432003140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432003141 binding surface 216432003142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216432003143 TPR motif; other site 216432003144 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 216432003145 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216432003146 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216432003147 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216432003148 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 216432003149 hypothetical protein; Reviewed; Region: PRK00024 216432003150 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216432003151 MPN+ (JAMM) motif; other site 216432003152 Zinc-binding site [ion binding]; other site 216432003153 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 216432003154 putative active site [active] 216432003155 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 216432003156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216432003157 motif II; other site 216432003158 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 216432003159 recombination factor protein RarA; Reviewed; Region: PRK13342 216432003160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432003161 Walker A motif; other site 216432003162 ATP binding site [chemical binding]; other site 216432003163 Walker B motif; other site 216432003164 arginine finger; other site 216432003165 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 216432003166 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 216432003167 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216432003168 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 216432003169 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216432003170 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 216432003171 starch binding outer membrane protein SusD; Region: SusD; cl17845 216432003172 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 216432003173 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432003174 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 216432003175 starch binding outer membrane protein SusD; Region: SusD; cd08977 216432003176 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 216432003177 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 216432003178 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 216432003179 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432003180 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432003181 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 216432003182 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432003183 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 216432003184 S17 interaction site [polypeptide binding]; other site 216432003185 S8 interaction site; other site 216432003186 16S rRNA interaction site [nucleotide binding]; other site 216432003187 streptomycin interaction site [chemical binding]; other site 216432003188 23S rRNA interaction site [nucleotide binding]; other site 216432003189 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 216432003190 30S ribosomal protein S7; Validated; Region: PRK05302 216432003191 elongation factor G; Reviewed; Region: PRK12739 216432003192 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 216432003193 G1 box; other site 216432003194 putative GEF interaction site [polypeptide binding]; other site 216432003195 GTP/Mg2+ binding site [chemical binding]; other site 216432003196 Switch I region; other site 216432003197 G2 box; other site 216432003198 G3 box; other site 216432003199 Switch II region; other site 216432003200 G4 box; other site 216432003201 G5 box; other site 216432003202 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 216432003203 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 216432003204 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 216432003205 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 216432003206 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 216432003207 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 216432003208 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 216432003209 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 216432003210 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 216432003211 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 216432003212 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 216432003213 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 216432003214 putative translocon binding site; other site 216432003215 protein-rRNA interface [nucleotide binding]; other site 216432003216 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 216432003217 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 216432003218 G-X-X-G motif; other site 216432003219 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 216432003220 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 216432003221 23S rRNA interface [nucleotide binding]; other site 216432003222 5S rRNA interface [nucleotide binding]; other site 216432003223 putative antibiotic binding site [chemical binding]; other site 216432003224 L25 interface [polypeptide binding]; other site 216432003225 L27 interface [polypeptide binding]; other site 216432003226 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 216432003227 putative translocon interaction site; other site 216432003228 23S rRNA interface [nucleotide binding]; other site 216432003229 signal recognition particle (SRP54) interaction site; other site 216432003230 L23 interface [polypeptide binding]; other site 216432003231 trigger factor interaction site; other site 216432003232 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 216432003233 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 216432003234 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 216432003235 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 216432003236 RNA binding site [nucleotide binding]; other site 216432003237 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 216432003238 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 216432003239 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 216432003240 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 216432003241 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 216432003242 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 216432003243 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216432003244 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216432003245 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 216432003246 5S rRNA interface [nucleotide binding]; other site 216432003247 L27 interface [polypeptide binding]; other site 216432003248 23S rRNA interface [nucleotide binding]; other site 216432003249 L5 interface [polypeptide binding]; other site 216432003250 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 216432003251 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 216432003252 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 216432003253 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 216432003254 23S rRNA binding site [nucleotide binding]; other site 216432003255 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 216432003256 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 216432003257 SecY translocase; Region: SecY; pfam00344 216432003258 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 216432003259 rRNA binding site [nucleotide binding]; other site 216432003260 predicted 30S ribosome binding site; other site 216432003261 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 216432003262 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 216432003263 30S ribosomal protein S13; Region: bact_S13; TIGR03631 216432003264 30S ribosomal protein S11; Validated; Region: PRK05309 216432003265 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 216432003266 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 216432003267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216432003268 RNA binding surface [nucleotide binding]; other site 216432003269 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 216432003270 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 216432003271 alphaNTD - beta interaction site [polypeptide binding]; other site 216432003272 alphaNTD homodimer interface [polypeptide binding]; other site 216432003273 alphaNTD - beta' interaction site [polypeptide binding]; other site 216432003274 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 216432003275 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 216432003276 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 216432003277 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 216432003278 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 216432003279 catalytic site [active] 216432003280 subunit interface [polypeptide binding]; other site 216432003281 enolase; Provisional; Region: eno; PRK00077 216432003282 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 216432003283 dimer interface [polypeptide binding]; other site 216432003284 metal binding site [ion binding]; metal-binding site 216432003285 substrate binding pocket [chemical binding]; other site 216432003286 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003287 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 216432003288 active site 216432003289 catalytic residues [active] 216432003290 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 216432003291 dimer interface [polypeptide binding]; other site 216432003292 Citrate synthase; Region: Citrate_synt; pfam00285 216432003293 active site 216432003294 citrylCoA binding site [chemical binding]; other site 216432003295 NADH binding [chemical binding]; other site 216432003296 cationic pore residues; other site 216432003297 oxalacetate/citrate binding site [chemical binding]; other site 216432003298 coenzyme A binding site [chemical binding]; other site 216432003299 catalytic triad [active] 216432003300 Amidinotransferase; Region: Amidinotransf; cl12043 216432003301 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 216432003302 Amidinotransferase; Region: Amidinotransf; pfam02274 216432003303 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216432003304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432003305 NAD(P) binding site [chemical binding]; other site 216432003306 active site 216432003307 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 216432003308 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 216432003309 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 216432003310 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432003311 active site 216432003312 HIGH motif; other site 216432003313 nucleotide binding site [chemical binding]; other site 216432003314 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 216432003315 KMSK motif region; other site 216432003316 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216432003317 tRNA binding surface [nucleotide binding]; other site 216432003318 anticodon binding site; other site 216432003319 signal recognition particle protein; Provisional; Region: PRK10867 216432003320 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 216432003321 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216432003322 P loop; other site 216432003323 GTP binding site [chemical binding]; other site 216432003324 Signal peptide binding domain; Region: SRP_SPB; pfam02978 216432003325 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 216432003326 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216432003327 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216432003328 homodimer interface [polypeptide binding]; other site 216432003329 NADP binding site [chemical binding]; other site 216432003330 substrate binding site [chemical binding]; other site 216432003331 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 216432003332 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 216432003333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216432003334 Histidine kinase; Region: HisKA_2; pfam07568 216432003335 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 216432003336 ATP binding site [chemical binding]; other site 216432003337 Mg2+ binding site [ion binding]; other site 216432003338 G-X-G motif; other site 216432003339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216432003340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432003341 active site 216432003342 phosphorylation site [posttranslational modification] 216432003343 intermolecular recognition site; other site 216432003344 dimerization interface [polypeptide binding]; other site 216432003345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216432003346 DNA binding residues [nucleotide binding] 216432003347 dimerization interface [polypeptide binding]; other site 216432003348 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 216432003349 dimer interface [polypeptide binding]; other site 216432003350 substrate binding site [chemical binding]; other site 216432003351 metal binding sites [ion binding]; metal-binding site 216432003352 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 216432003353 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 216432003354 Uncharacterized conserved protein [Function unknown]; Region: COG4850 216432003355 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 216432003356 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 216432003357 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 216432003358 Substrate-binding site [chemical binding]; other site 216432003359 Substrate specificity [chemical binding]; other site 216432003360 Domain of unknown function DUF302; Region: DUF302; pfam03625 216432003361 Domain of unknown function DUF302; Region: DUF302; pfam03625 216432003362 amidase; Provisional; Region: PRK06707 216432003363 Amidase; Region: Amidase; cl11426 216432003364 S-adenosylmethionine synthetase; Validated; Region: PRK05250 216432003365 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 216432003366 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 216432003367 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 216432003368 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 216432003369 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216432003370 homodimer interface [polypeptide binding]; other site 216432003371 substrate-cofactor binding pocket; other site 216432003372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432003373 catalytic residue [active] 216432003374 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 216432003375 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216432003376 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 216432003377 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 216432003378 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216432003379 Rrf2 family protein; Region: rrf2_super; TIGR00738 216432003380 Transcriptional regulator; Region: Rrf2; pfam02082 216432003381 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 216432003382 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216432003383 Active Sites [active] 216432003384 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 216432003385 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216432003386 Active Sites [active] 216432003387 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 216432003388 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 216432003389 CysD dimerization site [polypeptide binding]; other site 216432003390 G1 box; other site 216432003391 putative GEF interaction site [polypeptide binding]; other site 216432003392 GTP/Mg2+ binding site [chemical binding]; other site 216432003393 Switch I region; other site 216432003394 G2 box; other site 216432003395 G3 box; other site 216432003396 Switch II region; other site 216432003397 G4 box; other site 216432003398 G5 box; other site 216432003399 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 216432003400 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 216432003401 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 216432003402 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216432003403 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 216432003404 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216432003405 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 216432003406 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 216432003407 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216432003408 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 216432003409 Walker A/P-loop; other site 216432003410 ATP binding site [chemical binding]; other site 216432003411 Q-loop/lid; other site 216432003412 ABC transporter signature motif; other site 216432003413 Walker B; other site 216432003414 D-loop; other site 216432003415 H-loop/switch region; other site 216432003416 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 216432003417 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 216432003418 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 216432003419 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 216432003420 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 216432003421 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 216432003422 excinuclease ABC subunit B; Provisional; Region: PRK05298 216432003423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432003424 ATP binding site [chemical binding]; other site 216432003425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432003426 nucleotide binding region [chemical binding]; other site 216432003427 ATP-binding site [chemical binding]; other site 216432003428 Ultra-violet resistance protein B; Region: UvrB; pfam12344 216432003429 UvrB/uvrC motif; Region: UVR; pfam02151 216432003430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 216432003431 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216432003432 ATP binding site [chemical binding]; other site 216432003433 putative Mg++ binding site [ion binding]; other site 216432003434 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216432003435 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 216432003436 putative dimer interface [polypeptide binding]; other site 216432003437 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 216432003438 Predicted membrane protein [Function unknown]; Region: COG4325 216432003439 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 216432003440 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 216432003441 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 216432003442 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216432003443 active site 216432003444 NTP binding site [chemical binding]; other site 216432003445 metal binding triad [ion binding]; metal-binding site 216432003446 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216432003447 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432003448 Zn2+ binding site [ion binding]; other site 216432003449 Mg2+ binding site [ion binding]; other site 216432003450 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 216432003451 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 216432003452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432003453 active site 216432003454 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216432003455 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216432003456 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 216432003457 putative metal binding site; other site 216432003458 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 216432003459 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 216432003460 Substrate binding site; other site 216432003461 metal-binding site 216432003462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432003463 active site 216432003464 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216432003465 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216432003466 putative active site [active] 216432003467 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 216432003468 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 216432003469 trimer interface [polypeptide binding]; other site 216432003470 active site 216432003471 substrate binding site [chemical binding]; other site 216432003472 CoA binding site [chemical binding]; other site 216432003473 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 216432003474 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 216432003475 active site 216432003476 catalytic residues [active] 216432003477 metal binding site [ion binding]; metal-binding site 216432003478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216432003479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216432003480 active site 216432003481 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 216432003482 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216432003483 dimer interface [polypeptide binding]; other site 216432003484 active site 216432003485 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 216432003486 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216432003487 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216432003488 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216432003489 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216432003490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216432003491 substrate binding site [chemical binding]; other site 216432003492 oxyanion hole (OAH) forming residues; other site 216432003493 trimer interface [polypeptide binding]; other site 216432003494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216432003495 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 216432003496 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216432003497 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 216432003498 acyl-activating enzyme (AAE) consensus motif; other site 216432003499 putative AMP binding site [chemical binding]; other site 216432003500 putative active site [active] 216432003501 putative CoA binding site [chemical binding]; other site 216432003502 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 216432003503 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 216432003504 dimerization interface [polypeptide binding]; other site 216432003505 ATP binding site [chemical binding]; other site 216432003506 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 216432003507 dimerization interface [polypeptide binding]; other site 216432003508 ATP binding site [chemical binding]; other site 216432003509 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 216432003510 putative active site [active] 216432003511 catalytic triad [active] 216432003512 Endonuclease I; Region: Endonuclease_1; pfam04231 216432003513 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003514 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216432003515 putative active site [active] 216432003516 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 216432003517 adenylosuccinate lyase; Provisional; Region: PRK09285 216432003518 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 216432003519 tetramer interface [polypeptide binding]; other site 216432003520 active site 216432003521 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 216432003522 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216432003523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432003524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216432003525 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216432003526 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 216432003527 dimer interface [polypeptide binding]; other site 216432003528 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216432003529 catalytic triad [active] 216432003530 peroxidatic and resolving cysteines [active] 216432003531 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216432003532 catalytic residues [active] 216432003533 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 216432003534 dimer interface [polypeptide binding]; other site 216432003535 catalytic triad [active] 216432003536 peroxidatic and resolving cysteines [active] 216432003537 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 216432003538 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 216432003539 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 216432003540 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216432003541 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 216432003542 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216432003543 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 216432003544 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216432003545 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 216432003546 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 216432003547 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 216432003548 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 216432003549 dimerization interface [polypeptide binding]; other site 216432003550 active site 216432003551 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 216432003552 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216432003553 inhibitor-cofactor binding pocket; inhibition site 216432003554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432003555 catalytic residue [active] 216432003556 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 216432003557 FMN binding site [chemical binding]; other site 216432003558 dimer interface [polypeptide binding]; other site 216432003559 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 216432003560 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 216432003561 putative NAD(P) binding site [chemical binding]; other site 216432003562 homodimer interface [polypeptide binding]; other site 216432003563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432003564 dimerization interface [polypeptide binding]; other site 216432003565 putative DNA binding site [nucleotide binding]; other site 216432003566 putative Zn2+ binding site [ion binding]; other site 216432003567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216432003568 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 216432003569 dimer interface [polypeptide binding]; other site 216432003570 putative metal binding site [ion binding]; other site 216432003571 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216432003572 classical (c) SDRs; Region: SDR_c; cd05233 216432003573 NAD(P) binding site [chemical binding]; other site 216432003574 active site 216432003575 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 216432003576 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 216432003577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432003578 catalytic residue [active] 216432003579 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 216432003580 active site 216432003581 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 216432003582 active site 216432003583 ribulose/triose binding site [chemical binding]; other site 216432003584 phosphate binding site [ion binding]; other site 216432003585 substrate (anthranilate) binding pocket [chemical binding]; other site 216432003586 product (indole) binding pocket [chemical binding]; other site 216432003587 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 216432003588 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216432003589 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216432003590 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216432003591 Glutamine amidotransferase class-I; Region: GATase; pfam00117 216432003592 glutamine binding [chemical binding]; other site 216432003593 catalytic triad [active] 216432003594 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 216432003595 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216432003596 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216432003597 YceI-like domain; Region: YceI; pfam04264 216432003598 MarR family; Region: MarR_2; cl17246 216432003599 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216432003600 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432003601 catalytic residues [active] 216432003602 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 216432003603 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432003604 putative catalytic residue [active] 216432003605 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216432003606 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432003607 active site residue [active] 216432003608 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432003609 active site residue [active] 216432003610 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432003611 active site residue [active] 216432003612 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432003613 active site residue [active] 216432003614 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216432003615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216432003616 DNA binding site [nucleotide binding] 216432003617 domain linker motif; other site 216432003618 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216432003619 dimerization interface [polypeptide binding]; other site 216432003620 ligand binding site [chemical binding]; other site 216432003621 HlyD family secretion protein; Region: HlyD_2; pfam12700 216432003622 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432003623 Outer membrane efflux protein; Region: OEP; pfam02321 216432003624 Outer membrane efflux protein; Region: OEP; pfam02321 216432003625 HlyD family secretion protein; Region: HlyD; pfam00529 216432003626 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216432003627 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 216432003628 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216432003629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432003630 Walker A/P-loop; other site 216432003631 ATP binding site [chemical binding]; other site 216432003632 ABC transporter; Region: ABC_tran; pfam00005 216432003633 Q-loop/lid; other site 216432003634 ABC transporter signature motif; other site 216432003635 Walker B; other site 216432003636 D-loop; other site 216432003637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216432003638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216432003639 Yqey-like protein; Region: YqeY; pfam09424 216432003640 cell division protein FtsZ; Validated; Region: PRK09330 216432003641 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 216432003642 nucleotide binding site [chemical binding]; other site 216432003643 SulA interaction site; other site 216432003644 cell division protein FtsA; Region: ftsA; TIGR01174 216432003645 Cell division protein FtsA; Region: FtsA; smart00842 216432003646 Cell division protein FtsA; Region: FtsA; pfam14450 216432003647 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 216432003648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216432003649 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216432003650 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 216432003651 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 216432003652 active site 216432003653 homodimer interface [polypeptide binding]; other site 216432003654 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 216432003655 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 216432003656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216432003657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216432003658 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 216432003659 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 216432003660 Mg++ binding site [ion binding]; other site 216432003661 putative catalytic motif [active] 216432003662 putative substrate binding site [chemical binding]; other site 216432003663 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 216432003664 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216432003665 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216432003666 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216432003667 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 216432003668 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216432003669 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216432003670 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 216432003671 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 216432003672 MraW methylase family; Region: Methyltransf_5; cl17771 216432003673 cell division protein MraZ; Reviewed; Region: PRK00326 216432003674 MraZ protein; Region: MraZ; pfam02381 216432003675 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432003676 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 216432003677 G1 box; other site 216432003678 GTP/Mg2+ binding site [chemical binding]; other site 216432003679 Switch I region; other site 216432003680 G2 box; other site 216432003681 G3 box; other site 216432003682 Switch II region; other site 216432003683 G4 box; other site 216432003684 G5 box; other site 216432003685 gliding motility-associated protein GldC; Region: GldC; TIGR03515 216432003686 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 216432003687 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 216432003688 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 216432003689 homodimer interface [polypeptide binding]; other site 216432003690 NAD binding pocket [chemical binding]; other site 216432003691 ATP binding pocket [chemical binding]; other site 216432003692 Mg binding site [ion binding]; other site 216432003693 active-site loop [active] 216432003694 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216432003695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432003696 active site 216432003697 phosphorylation site [posttranslational modification] 216432003698 intermolecular recognition site; other site 216432003699 dimerization interface [polypeptide binding]; other site 216432003700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216432003701 DNA binding residues [nucleotide binding] 216432003702 dimerization interface [polypeptide binding]; other site 216432003703 DNA primase; Validated; Region: dnaG; PRK05667 216432003704 CHC2 zinc finger; Region: zf-CHC2; cl17510 216432003705 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 216432003706 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 216432003707 active site 216432003708 metal binding site [ion binding]; metal-binding site 216432003709 interdomain interaction site; other site 216432003710 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 216432003711 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216432003712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432003713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432003714 DNA binding residues [nucleotide binding] 216432003715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216432003716 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 216432003717 FAD binding site [chemical binding]; other site 216432003718 homotetramer interface [polypeptide binding]; other site 216432003719 substrate binding pocket [chemical binding]; other site 216432003720 catalytic base [active] 216432003721 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 216432003722 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216432003723 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 216432003724 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 216432003725 NAD(P) binding pocket [chemical binding]; other site 216432003726 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 216432003727 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 216432003728 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216432003729 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 216432003730 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 216432003731 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216432003732 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 216432003733 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 216432003734 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 216432003735 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 216432003736 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 216432003737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216432003738 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432003739 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432003740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216432003741 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432003742 Cell division protein ZapA; Region: ZapA; pfam05164 216432003743 phosphodiesterase; Provisional; Region: PRK12704 216432003744 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432003745 Zn2+ binding site [ion binding]; other site 216432003746 Mg2+ binding site [ion binding]; other site 216432003747 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 216432003748 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 216432003749 homodimer interface [polypeptide binding]; other site 216432003750 metal binding site [ion binding]; metal-binding site 216432003751 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 216432003752 homodimer interface [polypeptide binding]; other site 216432003753 active site 216432003754 putative chemical substrate binding site [chemical binding]; other site 216432003755 metal binding site [ion binding]; metal-binding site 216432003756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432003757 Methyltransferase domain; Region: Methyltransf_11; pfam08241 216432003758 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216432003759 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216432003760 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216432003761 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216432003762 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216432003763 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 216432003764 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216432003765 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216432003766 shikimate binding site; other site 216432003767 NAD(P) binding site [chemical binding]; other site 216432003768 Domain of unknown function (DUF368); Region: DUF368; pfam04018 216432003769 Domain of unknown function (DUF368); Region: DUF368; pfam04018 216432003770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432003771 binding surface 216432003772 TPR motif; other site 216432003773 TPR repeat; Region: TPR_11; pfam13414 216432003774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432003775 binding surface 216432003776 TPR motif; other site 216432003777 TPR repeat; Region: TPR_11; pfam13414 216432003778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432003779 TPR motif; other site 216432003780 binding surface 216432003781 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 216432003782 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216432003783 inhibitor-cofactor binding pocket; inhibition site 216432003784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432003785 catalytic residue [active] 216432003786 OstA-like protein; Region: OstA_2; pfam13100 216432003787 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003788 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 216432003789 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 216432003790 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 216432003791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432003792 non-specific DNA binding site [nucleotide binding]; other site 216432003793 salt bridge; other site 216432003794 sequence-specific DNA binding site [nucleotide binding]; other site 216432003795 Tic20-like protein; Region: Tic20; pfam09685 216432003796 Domain of unknown function DUF87; Region: DUF87; pfam01935 216432003797 AAA-like domain; Region: AAA_10; pfam12846 216432003798 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 216432003799 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 216432003800 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 216432003801 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 216432003802 asparagine synthetase B; Provisional; Region: asnB; PRK09431 216432003803 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 216432003804 active site 216432003805 dimer interface [polypeptide binding]; other site 216432003806 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 216432003807 Ligand Binding Site [chemical binding]; other site 216432003808 Molecular Tunnel; other site 216432003809 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 216432003810 catalytic site [active] 216432003811 Asp-box motif; other site 216432003812 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003813 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 216432003814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432003815 ATP binding site [chemical binding]; other site 216432003816 Mg2+ binding site [ion binding]; other site 216432003817 G-X-G motif; other site 216432003818 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 216432003819 anchoring element; other site 216432003820 dimer interface [polypeptide binding]; other site 216432003821 ATP binding site [chemical binding]; other site 216432003822 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 216432003823 active site 216432003824 putative metal-binding site [ion binding]; other site 216432003825 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216432003826 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432003827 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432003828 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432003829 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432003830 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216432003831 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216432003832 intersubunit interface [polypeptide binding]; other site 216432003833 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 216432003834 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 216432003835 B12 binding site [chemical binding]; other site 216432003836 cobalt ligand [ion binding]; other site 216432003837 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 216432003838 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 216432003839 Walker A; other site 216432003840 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 216432003841 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 216432003842 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216432003843 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 216432003844 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432003845 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432003846 Leucine carboxyl methyltransferase; Region: LCM; cl01306 216432003847 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216432003848 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216432003849 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216432003850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432003851 putative DNA binding site [nucleotide binding]; other site 216432003852 putative Zn2+ binding site [ion binding]; other site 216432003853 AsnC family; Region: AsnC_trans_reg; pfam01037 216432003854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216432003855 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 216432003856 DNA binding residues [nucleotide binding] 216432003857 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 216432003858 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 216432003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432003860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216432003861 putative substrate translocation pore; other site 216432003862 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 216432003863 CrcB-like protein; Region: CRCB; cl09114 216432003864 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 216432003865 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 216432003866 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216432003867 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 216432003868 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216432003869 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 216432003870 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216432003871 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 216432003872 Predicted membrane protein [Function unknown]; Region: COG2323 216432003873 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216432003874 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216432003875 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 216432003876 putative hydrophobic ligand binding site [chemical binding]; other site 216432003877 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 216432003878 Peptidase family M49; Region: Peptidase_M49; pfam03571 216432003879 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 216432003880 Peptidase family M28; Region: Peptidase_M28; pfam04389 216432003881 active site 216432003882 metal binding site [ion binding]; metal-binding site 216432003883 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432003884 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 216432003885 metal binding site [ion binding]; metal-binding site 216432003886 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 216432003887 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216432003888 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216432003889 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 216432003890 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432003891 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216432003892 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216432003893 N-terminal plug; other site 216432003894 ligand-binding site [chemical binding]; other site 216432003895 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 216432003896 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 216432003897 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 216432003898 homodimer interface [polypeptide binding]; other site 216432003899 substrate-cofactor binding pocket; other site 216432003900 catalytic residue [active] 216432003901 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 216432003902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432003903 ATP binding site [chemical binding]; other site 216432003904 Mg2+ binding site [ion binding]; other site 216432003905 G-X-G motif; other site 216432003906 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 216432003907 ATP binding site [chemical binding]; other site 216432003908 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 216432003909 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 216432003910 Rhomboid family; Region: Rhomboid; pfam01694 216432003911 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 216432003912 putative catalytic site [active] 216432003913 putative metal binding site [ion binding]; other site 216432003914 putative phosphate binding site [ion binding]; other site 216432003915 WbqC-like protein family; Region: WbqC; pfam08889 216432003916 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 216432003917 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216432003918 Catalytic site [active] 216432003919 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216432003920 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 216432003921 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216432003922 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 216432003923 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 216432003924 ParB-like nuclease domain; Region: ParBc; pfam02195 216432003925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432003926 non-specific DNA binding site [nucleotide binding]; other site 216432003927 salt bridge; other site 216432003928 sequence-specific DNA binding site [nucleotide binding]; other site 216432003929 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216432003930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216432003931 P-loop; other site 216432003932 Magnesium ion binding site [ion binding]; other site 216432003933 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216432003934 Magnesium ion binding site [ion binding]; other site 216432003935 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 216432003936 short chain dehydrogenase; Provisional; Region: PRK07677 216432003937 NAD(P) binding site [chemical binding]; other site 216432003938 substrate binding site [chemical binding]; other site 216432003939 homotetramer interface [polypeptide binding]; other site 216432003940 active site 216432003941 homodimer interface [polypeptide binding]; other site 216432003942 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 216432003943 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 216432003944 active site 216432003945 substrate binding site [chemical binding]; other site 216432003946 coenzyme B12 binding site [chemical binding]; other site 216432003947 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 216432003948 B12 binding site [chemical binding]; other site 216432003949 cobalt ligand [ion binding]; other site 216432003950 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 216432003951 heterodimer interface [polypeptide binding]; other site 216432003952 substrate interaction site [chemical binding]; other site 216432003953 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 216432003954 Septum formation initiator; Region: DivIC; pfam04977 216432003955 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 216432003956 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 216432003957 ATP-binding site [chemical binding]; other site 216432003958 Sugar specificity; other site 216432003959 Pyrimidine base specificity; other site 216432003960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432003961 putative substrate translocation pore; other site 216432003962 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 216432003963 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 216432003964 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 216432003965 nucleotide binding site [chemical binding]; other site 216432003966 NEF interaction site [polypeptide binding]; other site 216432003967 SBD interface [polypeptide binding]; other site 216432003968 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216432003969 active site 216432003970 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 216432003971 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 216432003972 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216432003973 active site 216432003974 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216432003975 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 216432003976 putative catalytic residue [active] 216432003977 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 216432003978 dimer interface [polypeptide binding]; other site 216432003979 putative tRNA-binding site [nucleotide binding]; other site 216432003980 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 216432003981 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216432003982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432003983 Walker A/P-loop; other site 216432003984 ATP binding site [chemical binding]; other site 216432003985 Q-loop/lid; other site 216432003986 ABC transporter signature motif; other site 216432003987 Walker B; other site 216432003988 D-loop; other site 216432003989 H-loop/switch region; other site 216432003990 ABC transporter; Region: ABC_tran_2; pfam12848 216432003991 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432003992 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216432003993 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216432003994 Chain length determinant protein; Region: Wzz; cl15801 216432003995 AAA domain; Region: AAA_31; pfam13614 216432003996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216432003997 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 216432003998 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 216432003999 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 216432004000 Walker A/P-loop; other site 216432004001 ATP binding site [chemical binding]; other site 216432004002 Q-loop/lid; other site 216432004003 ABC transporter signature motif; other site 216432004004 Walker B; other site 216432004005 D-loop; other site 216432004006 H-loop/switch region; other site 216432004007 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 216432004008 putative carbohydrate binding site [chemical binding]; other site 216432004009 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 216432004010 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 216432004011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432004012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216432004013 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216432004014 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 216432004015 active site 216432004016 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 216432004017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432004018 active site 216432004019 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432004020 active site 216432004021 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216432004022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432004023 active site 216432004024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432004025 active site 216432004026 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 216432004027 ligand binding site; other site 216432004028 tetramer interface; other site 216432004029 NeuB family; Region: NeuB; pfam03102 216432004030 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216432004031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432004032 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216432004033 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216432004034 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432004035 active site 216432004036 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216432004037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216432004038 active site 216432004039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432004040 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432004041 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 216432004042 aspartate aminotransferase; Provisional; Region: PRK05764 216432004043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216432004044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004045 homodimer interface [polypeptide binding]; other site 216432004046 catalytic residue [active] 216432004047 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216432004048 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 216432004049 putative di-iron ligands [ion binding]; other site 216432004050 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 216432004051 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 216432004052 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 216432004053 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 216432004054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216432004055 Walker A/P-loop; other site 216432004056 ATP binding site [chemical binding]; other site 216432004057 Q-loop/lid; other site 216432004058 ABC transporter signature motif; other site 216432004059 Walker B; other site 216432004060 D-loop; other site 216432004061 H-loop/switch region; other site 216432004062 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 216432004063 Prephenate dehydratase; Region: PDT; pfam00800 216432004064 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 216432004065 putative L-Phe binding site [chemical binding]; other site 216432004066 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 216432004067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216432004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004069 homodimer interface [polypeptide binding]; other site 216432004070 catalytic residue [active] 216432004071 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 216432004072 Chorismate mutase type II; Region: CM_2; smart00830 216432004073 GTPase RsgA; Reviewed; Region: PRK00098 216432004074 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 216432004075 RNA binding site [nucleotide binding]; other site 216432004076 homodimer interface [polypeptide binding]; other site 216432004077 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 216432004078 GTPase/Zn-binding domain interface [polypeptide binding]; other site 216432004079 GTP/Mg2+ binding site [chemical binding]; other site 216432004080 G4 box; other site 216432004081 G5 box; other site 216432004082 G1 box; other site 216432004083 Switch I region; other site 216432004084 G2 box; other site 216432004085 G3 box; other site 216432004086 Switch II region; other site 216432004087 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 216432004088 putative active site [active] 216432004089 dimerization interface [polypeptide binding]; other site 216432004090 putative tRNAtyr binding site [nucleotide binding]; other site 216432004091 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216432004092 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 216432004093 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216432004094 homotrimer interaction site [polypeptide binding]; other site 216432004095 putative active site [active] 216432004096 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 216432004097 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 216432004098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004099 catalytic residue [active] 216432004100 homoserine kinase; Provisional; Region: PRK01212 216432004101 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 216432004102 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 216432004103 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 216432004104 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 216432004105 putative catalytic residues [active] 216432004106 putative nucleotide binding site [chemical binding]; other site 216432004107 putative aspartate binding site [chemical binding]; other site 216432004108 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 216432004109 dimer interface [polypeptide binding]; other site 216432004110 putative threonine allosteric regulatory site; other site 216432004111 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 216432004112 putative threonine allosteric regulatory site; other site 216432004113 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 216432004114 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216432004115 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216432004116 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 216432004117 NAD binding site [chemical binding]; other site 216432004118 catalytic residues [active] 216432004119 short chain dehydrogenase; Provisional; Region: PRK08339 216432004120 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 216432004121 putative NAD(P) binding site [chemical binding]; other site 216432004122 putative active site [active] 216432004123 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432004124 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 216432004125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432004126 S-adenosylmethionine binding site [chemical binding]; other site 216432004127 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 216432004128 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216432004129 active site 216432004130 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 216432004131 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 216432004132 Penicillinase repressor; Region: Pencillinase_R; pfam03965 216432004133 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 216432004134 active site 216432004135 Zn binding site [ion binding]; other site 216432004136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432004137 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 216432004138 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 216432004139 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 216432004140 Protein of unknown function (DUF819); Region: DUF819; cl02317 216432004141 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 216432004142 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 216432004143 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 216432004144 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216432004145 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 216432004146 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216432004147 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216432004148 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 216432004149 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 216432004150 Predicted membrane protein [Function unknown]; Region: COG4270 216432004151 heat shock protein 90; Provisional; Region: PRK05218 216432004152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432004153 ATP binding site [chemical binding]; other site 216432004154 Mg2+ binding site [ion binding]; other site 216432004155 G-X-G motif; other site 216432004156 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 216432004157 ABC1 family; Region: ABC1; cl17513 216432004158 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216432004159 active site 216432004160 ATP binding site [chemical binding]; other site 216432004161 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216432004162 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216432004163 dimer interface [polypeptide binding]; other site 216432004164 active site 216432004165 CoA binding pocket [chemical binding]; other site 216432004166 EamA-like transporter family; Region: EamA; cl17759 216432004167 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432004168 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 216432004169 active site 216432004170 Zn binding site [ion binding]; other site 216432004171 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432004172 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 216432004173 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 216432004174 active site 216432004175 Zn binding site [ion binding]; other site 216432004176 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432004177 CoA binding domain; Region: CoA_binding_2; pfam13380 216432004178 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 216432004179 Na binding site [ion binding]; other site 216432004180 recombination protein RecR; Reviewed; Region: recR; PRK00076 216432004181 RecR protein; Region: RecR; pfam02132 216432004182 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 216432004183 putative active site [active] 216432004184 putative metal-binding site [ion binding]; other site 216432004185 tetramer interface [polypeptide binding]; other site 216432004186 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216432004187 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 216432004188 Probable Catalytic site; other site 216432004189 metal-binding site 216432004190 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216432004191 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216432004192 E3 interaction surface; other site 216432004193 lipoyl attachment site [posttranslational modification]; other site 216432004194 e3 binding domain; Region: E3_binding; pfam02817 216432004195 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216432004196 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 216432004197 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 216432004198 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216432004199 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 216432004200 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 216432004201 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 216432004202 Zn binding site [ion binding]; other site 216432004203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432004204 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 216432004205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432004206 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 216432004207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 216432004208 DNA binding residues [nucleotide binding] 216432004209 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 216432004210 glycine dehydrogenase; Provisional; Region: PRK05367 216432004211 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216432004212 tetramer interface [polypeptide binding]; other site 216432004213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004214 catalytic residue [active] 216432004215 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216432004216 tetramer interface [polypeptide binding]; other site 216432004217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004218 catalytic residue [active] 216432004219 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216432004220 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216432004221 dimer interface [polypeptide binding]; other site 216432004222 active site 216432004223 CoA binding pocket [chemical binding]; other site 216432004224 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432004225 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216432004226 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 216432004227 DXD motif; other site 216432004228 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 216432004229 Sulfatase; Region: Sulfatase; cl17466 216432004230 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 216432004231 Permease; Region: Permease; pfam02405 216432004232 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 216432004233 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 216432004234 Walker A/P-loop; other site 216432004235 ATP binding site [chemical binding]; other site 216432004236 Q-loop/lid; other site 216432004237 ABC transporter signature motif; other site 216432004238 Walker B; other site 216432004239 D-loop; other site 216432004240 H-loop/switch region; other site 216432004241 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 216432004242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432004243 FeS/SAM binding site; other site 216432004244 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 216432004245 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 216432004246 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 216432004247 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 216432004248 hinge; other site 216432004249 active site 216432004250 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 216432004251 homodimer interface [polypeptide binding]; other site 216432004252 metal binding site [ion binding]; metal-binding site 216432004253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432004254 kynureninase; Region: kynureninase; TIGR01814 216432004255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432004256 catalytic residue [active] 216432004257 Helix-turn-helix domain; Region: HTH_18; pfam12833 216432004258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216432004259 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 216432004260 Penicillinase repressor; Region: Pencillinase_R; pfam03965 216432004261 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 216432004262 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 216432004263 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 216432004264 DNA photolyase; Region: DNA_photolyase; pfam00875 216432004265 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 216432004266 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 216432004267 methionine sulfoxide reductase A; Provisional; Region: PRK14054 216432004268 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 216432004269 Putative zinc ribbon domain; Region: DUF164; pfam02591 216432004270 Uncharacterized conserved protein [Function unknown]; Region: COG0327 216432004271 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 216432004272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 216432004273 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 216432004274 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 216432004275 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 216432004276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 216432004277 TPR repeat; Region: TPR_11; pfam13414 216432004278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004279 binding surface 216432004280 TPR motif; other site 216432004281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432004282 dimer interface [polypeptide binding]; other site 216432004283 phosphorylation site [posttranslational modification] 216432004284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432004285 ATP binding site [chemical binding]; other site 216432004286 Mg2+ binding site [ion binding]; other site 216432004287 G-X-G motif; other site 216432004288 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216432004289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432004290 active site 216432004291 phosphorylation site [posttranslational modification] 216432004292 intermolecular recognition site; other site 216432004293 dimerization interface [polypeptide binding]; other site 216432004294 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 216432004295 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 216432004296 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216432004297 lipoyl synthase; Provisional; Region: PRK05481 216432004298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432004299 FeS/SAM binding site; other site 216432004300 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216432004301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432004302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432004303 DNA binding residues [nucleotide binding] 216432004304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216432004305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432004306 active site 216432004307 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 216432004308 Fasciclin domain; Region: Fasciclin; pfam02469 216432004309 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 216432004310 FAD binding domain; Region: FAD_binding_4; pfam01565 216432004311 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 216432004312 aspartate aminotransferase; Provisional; Region: PRK07568 216432004313 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216432004314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004315 homodimer interface [polypeptide binding]; other site 216432004316 catalytic residue [active] 216432004317 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 216432004318 catalytic motif [active] 216432004319 Catalytic residue [active] 216432004320 Aspartyl protease; Region: Asp_protease_2; pfam13650 216432004321 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216432004322 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 216432004323 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 216432004324 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432004325 active site 216432004326 HIGH motif; other site 216432004327 nucleotide binding site [chemical binding]; other site 216432004328 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216432004329 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216432004330 active site 216432004331 KMSKS motif; other site 216432004332 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 216432004333 tRNA binding surface [nucleotide binding]; other site 216432004334 anticodon binding site; other site 216432004335 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216432004336 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 216432004337 Acyl CoA binding protein; Region: ACBP; pfam00887 216432004338 acyl-CoA binding pocket [chemical binding]; other site 216432004339 CoA binding site [chemical binding]; other site 216432004340 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 216432004341 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 216432004342 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 216432004343 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 216432004344 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 216432004345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432004346 Walker A motif; other site 216432004347 ATP binding site [chemical binding]; other site 216432004348 Walker B motif; other site 216432004349 arginine finger; other site 216432004350 Peptidase family M41; Region: Peptidase_M41; pfam01434 216432004351 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 216432004352 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 216432004353 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 216432004354 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432004355 active site 216432004356 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 216432004357 active site 216432004358 Ap6A binding site [chemical binding]; other site 216432004359 nudix motif; other site 216432004360 metal binding site [ion binding]; metal-binding site 216432004361 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 216432004362 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 216432004363 putative active site [active] 216432004364 Zn binding site [ion binding]; other site 216432004365 Penicillinase repressor; Region: Pencillinase_R; pfam03965 216432004366 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 216432004367 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 216432004368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004369 binding surface 216432004370 TPR motif; other site 216432004371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004372 TPR motif; other site 216432004373 binding surface 216432004374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004375 binding surface 216432004376 TPR motif; other site 216432004377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004378 binding surface 216432004379 TPR motif; other site 216432004380 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 216432004381 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 216432004382 active site 216432004383 (T/H)XGH motif; other site 216432004384 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 216432004385 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216432004386 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216432004387 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 216432004388 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 216432004389 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216432004390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216432004391 RNA binding surface [nucleotide binding]; other site 216432004392 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216432004393 active site 216432004394 hypothetical protein; Validated; Region: PRK02101 216432004395 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 216432004396 putative active site [active] 216432004397 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 216432004398 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 216432004399 substrate binding site [chemical binding]; other site 216432004400 active site 216432004401 catalytic residues [active] 216432004402 heterodimer interface [polypeptide binding]; other site 216432004403 NAD-dependent deacetylase; Provisional; Region: PRK00481 216432004404 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 216432004405 NAD+ binding site [chemical binding]; other site 216432004406 substrate binding site [chemical binding]; other site 216432004407 Zn binding site [ion binding]; other site 216432004408 putative hydrolase; Provisional; Region: PRK11460 216432004409 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 216432004410 Tic20-like protein; Region: Tic20; pfam09685 216432004411 dihydroorotase; Validated; Region: pyrC; PRK09357 216432004412 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432004413 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 216432004414 active site 216432004415 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 216432004416 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216432004417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216432004418 GAF domain; Region: GAF; pfam01590 216432004419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432004420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432004421 dimer interface [polypeptide binding]; other site 216432004422 phosphorylation site [posttranslational modification] 216432004423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432004424 ATP binding site [chemical binding]; other site 216432004425 Mg2+ binding site [ion binding]; other site 216432004426 G-X-G motif; other site 216432004427 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216432004428 GAF domain; Region: GAF; pfam01590 216432004429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432004430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432004431 dimer interface [polypeptide binding]; other site 216432004432 phosphorylation site [posttranslational modification] 216432004433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432004434 ATP binding site [chemical binding]; other site 216432004435 Mg2+ binding site [ion binding]; other site 216432004436 G-X-G motif; other site 216432004437 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 216432004438 conserved hypothetical integral membrane protein; Region: TIGR03766 216432004439 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 216432004440 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 216432004441 tetramer interface [polypeptide binding]; other site 216432004442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004443 catalytic residue [active] 216432004444 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 216432004445 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 216432004446 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432004447 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432004448 ligand binding site [chemical binding]; other site 216432004449 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 216432004450 hypothetical protein; Provisional; Region: PRK14623 216432004451 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 216432004452 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216432004453 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216432004454 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216432004455 dimer interface [polypeptide binding]; other site 216432004456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004457 catalytic residue [active] 216432004458 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216432004459 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432004460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432004461 catalytic residue [active] 216432004462 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 216432004463 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 216432004464 Response regulator receiver domain; Region: Response_reg; pfam00072 216432004465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432004466 active site 216432004467 phosphorylation site [posttranslational modification] 216432004468 intermolecular recognition site; other site 216432004469 dimerization interface [polypeptide binding]; other site 216432004470 PglZ domain; Region: PglZ; pfam08665 216432004471 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 216432004472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432004473 Zn2+ binding site [ion binding]; other site 216432004474 Mg2+ binding site [ion binding]; other site 216432004475 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 216432004476 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 216432004477 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 216432004478 trimer interface [polypeptide binding]; other site 216432004479 active site 216432004480 UDP-GlcNAc binding site [chemical binding]; other site 216432004481 lipid binding site [chemical binding]; lipid-binding site 216432004482 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 216432004483 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 216432004484 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 216432004485 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 216432004486 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 216432004487 active site 216432004488 elongation factor P; Validated; Region: PRK00529 216432004489 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 216432004490 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 216432004491 RNA binding site [nucleotide binding]; other site 216432004492 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 216432004493 RNA binding site [nucleotide binding]; other site 216432004494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432004495 S-adenosylmethionine binding site [chemical binding]; other site 216432004496 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 216432004497 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 216432004498 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 216432004499 trimer interface [polypeptide binding]; other site 216432004500 active site 216432004501 UDP-GlcNAc binding site [chemical binding]; other site 216432004502 lipid binding site [chemical binding]; lipid-binding site 216432004503 SnoaL-like domain; Region: SnoaL_2; pfam12680 216432004504 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 216432004505 CoA binding domain; Region: CoA_binding; smart00881 216432004506 CoA-ligase; Region: Ligase_CoA; pfam00549 216432004507 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216432004508 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216432004509 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216432004510 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216432004511 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216432004512 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 216432004513 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216432004514 NAD(P) binding site [chemical binding]; other site 216432004515 homotetramer interface [polypeptide binding]; other site 216432004516 homodimer interface [polypeptide binding]; other site 216432004517 active site 216432004518 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 216432004519 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216432004520 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 216432004521 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216432004522 DNA-binding site [nucleotide binding]; DNA binding site 216432004523 RNA-binding motif; other site 216432004524 YceI-like domain; Region: YceI; pfam04264 216432004525 GrpE; Region: GrpE; pfam01025 216432004526 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 216432004527 dimer interface [polypeptide binding]; other site 216432004528 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 216432004529 chaperone protein DnaJ; Provisional; Region: PRK14289 216432004530 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216432004531 HSP70 interaction site [polypeptide binding]; other site 216432004532 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216432004533 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216432004534 dimer interface [polypeptide binding]; other site 216432004535 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 216432004536 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 216432004537 Walker A/P-loop; other site 216432004538 ATP binding site [chemical binding]; other site 216432004539 Q-loop/lid; other site 216432004540 ABC transporter signature motif; other site 216432004541 Walker B; other site 216432004542 D-loop; other site 216432004543 H-loop/switch region; other site 216432004544 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 216432004545 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 216432004546 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432004547 Response regulator receiver domain; Region: Response_reg; pfam00072 216432004548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432004549 active site 216432004550 phosphorylation site [posttranslational modification] 216432004551 intermolecular recognition site; other site 216432004552 dimerization interface [polypeptide binding]; other site 216432004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432004554 Walker A motif; other site 216432004555 ATP binding site [chemical binding]; other site 216432004556 Walker B motif; other site 216432004557 arginine finger; other site 216432004558 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216432004559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432004560 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216432004561 DNA binding residues [nucleotide binding] 216432004562 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216432004563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432004564 CAAX protease self-immunity; Region: Abi; pfam02517 216432004565 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216432004566 AMP binding site [chemical binding]; other site 216432004567 active site 216432004568 acyl-activating enzyme (AAE) consensus motif; other site 216432004569 CoA binding site [chemical binding]; other site 216432004570 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 216432004571 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216432004572 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 216432004573 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 216432004574 active site 216432004575 substrate binding site [chemical binding]; other site 216432004576 Mg2+ binding site [ion binding]; other site 216432004577 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 216432004578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432004579 Walker A/P-loop; other site 216432004580 ATP binding site [chemical binding]; other site 216432004581 Q-loop/lid; other site 216432004582 ABC transporter signature motif; other site 216432004583 Walker B; other site 216432004584 D-loop; other site 216432004585 H-loop/switch region; other site 216432004586 ABC transporter; Region: ABC_tran_2; pfam12848 216432004587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432004588 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 216432004589 Guanylyl transferase CofC like; Region: CofC; cl17472 216432004590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 216432004591 Walker A motif; other site 216432004592 ATP binding site [chemical binding]; other site 216432004593 Walker B motif; other site 216432004594 arginine finger; other site 216432004595 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432004596 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432004597 catalytic residues [active] 216432004598 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 216432004599 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 216432004600 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 216432004601 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 216432004602 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216432004603 PhoH-like protein; Region: PhoH; pfam02562 216432004604 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 216432004605 ATP binding site [chemical binding]; other site 216432004606 active site 216432004607 substrate binding site [chemical binding]; other site 216432004608 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432004609 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 216432004610 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432004611 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432004612 ligand binding site [chemical binding]; other site 216432004613 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216432004614 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 216432004615 NAD(P) binding site [chemical binding]; other site 216432004616 catalytic residues [active] 216432004617 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 216432004618 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 216432004619 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 216432004620 dimerization interface [polypeptide binding]; other site 216432004621 active site 216432004622 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 216432004623 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 216432004624 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 216432004625 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 216432004626 peptidase T; Region: peptidase-T; TIGR01882 216432004627 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 216432004628 metal binding site [ion binding]; metal-binding site 216432004629 dimer interface [polypeptide binding]; other site 216432004630 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 216432004631 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 216432004632 quinone interaction residues [chemical binding]; other site 216432004633 active site 216432004634 catalytic residues [active] 216432004635 FMN binding site [chemical binding]; other site 216432004636 substrate binding site [chemical binding]; other site 216432004637 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216432004638 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 216432004639 active site 216432004640 catalytic residues [active] 216432004641 metal binding site [ion binding]; metal-binding site 216432004642 Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406 216432004643 putative active site [active] 216432004644 putative metal binding site [ion binding]; other site 216432004645 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 216432004646 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216432004647 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 216432004648 CTP synthetase; Validated; Region: pyrG; PRK05380 216432004649 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 216432004650 Catalytic site [active] 216432004651 active site 216432004652 UTP binding site [chemical binding]; other site 216432004653 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 216432004654 active site 216432004655 putative oxyanion hole; other site 216432004656 catalytic triad [active] 216432004657 membrane protein insertase; Provisional; Region: PRK01318 216432004658 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 216432004659 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 216432004660 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 216432004661 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216432004662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 216432004663 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 216432004664 active site 216432004665 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432004666 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216432004667 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216432004668 N-terminal plug; other site 216432004669 ligand-binding site [chemical binding]; other site 216432004670 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; pfam05090 216432004671 Imelysin; Region: Peptidase_M75; pfam09375 216432004672 Haem-binding domain; Region: Haem_bd; pfam14376 216432004673 diaminopimelate decarboxylase; Region: lysA; TIGR01048 216432004674 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 216432004675 active site 216432004676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216432004677 substrate binding site [chemical binding]; other site 216432004678 catalytic residues [active] 216432004679 dimer interface [polypeptide binding]; other site 216432004680 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 216432004681 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 216432004682 CoA-ligase; Region: Ligase_CoA; pfam00549 216432004683 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216432004684 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 216432004685 PA/protease or protease-like domain interface [polypeptide binding]; other site 216432004686 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216432004687 Peptidase family M28; Region: Peptidase_M28; pfam04389 216432004688 metal binding site [ion binding]; metal-binding site 216432004689 ZIP Zinc transporter; Region: Zip; pfam02535 216432004690 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432004691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432004692 S-adenosylmethionine binding site [chemical binding]; other site 216432004693 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 216432004694 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 216432004695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216432004696 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 216432004697 TRAM domain; Region: TRAM; pfam01938 216432004698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432004699 S-adenosylmethionine binding site [chemical binding]; other site 216432004700 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 216432004701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216432004702 inhibitor-cofactor binding pocket; inhibition site 216432004703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004704 catalytic residue [active] 216432004705 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 216432004706 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432004707 Smr domain; Region: Smr; pfam01713 216432004708 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 216432004709 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 216432004710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432004711 catalytic residue [active] 216432004712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216432004713 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216432004714 Walker A/P-loop; other site 216432004715 ATP binding site [chemical binding]; other site 216432004716 Q-loop/lid; other site 216432004717 ABC transporter signature motif; other site 216432004718 Walker B; other site 216432004719 D-loop; other site 216432004720 H-loop/switch region; other site 216432004721 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 216432004722 putative ligand binding site [chemical binding]; other site 216432004723 methionine sulfoxide reductase A; Provisional; Region: PRK14054 216432004724 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 216432004725 homodecamer interface [polypeptide binding]; other site 216432004726 GTP cyclohydrolase I; Provisional; Region: PLN03044 216432004727 active site 216432004728 putative catalytic site residues [active] 216432004729 zinc binding site [ion binding]; other site 216432004730 GTP-CH-I/GFRP interaction surface; other site 216432004731 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432004732 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432004733 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432004734 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 216432004735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004736 TPR motif; other site 216432004737 binding surface 216432004738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216432004739 Histidine kinase; Region: HisKA_2; pfam07568 216432004740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432004741 ATP binding site [chemical binding]; other site 216432004742 Mg2+ binding site [ion binding]; other site 216432004743 G-X-G motif; other site 216432004744 Response regulator receiver domain; Region: Response_reg; pfam00072 216432004745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432004746 active site 216432004747 phosphorylation site [posttranslational modification] 216432004748 intermolecular recognition site; other site 216432004749 dimerization interface [polypeptide binding]; other site 216432004750 LytTr DNA-binding domain; Region: LytTR; smart00850 216432004751 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216432004752 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 216432004753 putative ligand binding site [chemical binding]; other site 216432004754 NAD binding site [chemical binding]; other site 216432004755 dimerization interface [polypeptide binding]; other site 216432004756 catalytic site [active] 216432004757 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 216432004758 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432004759 catalytic residue [active] 216432004760 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216432004761 4Fe-4S binding domain; Region: Fer4; cl02805 216432004762 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 216432004763 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 216432004764 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 216432004765 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 216432004766 active site 216432004767 dimer interface [polypeptide binding]; other site 216432004768 catalytic nucleophile [active] 216432004769 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 216432004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432004771 putative substrate translocation pore; other site 216432004772 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432004773 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432004774 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432004775 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 216432004776 malate dehydrogenase; Reviewed; Region: PRK06223 216432004777 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 216432004778 dimer interface [polypeptide binding]; other site 216432004779 NAD(P) binding site [chemical binding]; other site 216432004780 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216432004781 substrate binding site [chemical binding]; other site 216432004782 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 216432004783 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 216432004784 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 216432004785 Protein export membrane protein; Region: SecD_SecF; pfam02355 216432004786 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 216432004787 Peptidase family M28; Region: Peptidase_M28; pfam04389 216432004788 metal binding site [ion binding]; metal-binding site 216432004789 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 216432004790 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 216432004791 GDP-binding site [chemical binding]; other site 216432004792 ACT binding site; other site 216432004793 IMP binding site; other site 216432004794 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216432004795 metal binding site 2 [ion binding]; metal-binding site 216432004796 putative DNA binding helix; other site 216432004797 metal binding site 1 [ion binding]; metal-binding site 216432004798 dimer interface [polypeptide binding]; other site 216432004799 structural Zn2+ binding site [ion binding]; other site 216432004800 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 216432004801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432004802 Zn2+ binding site [ion binding]; other site 216432004803 Mg2+ binding site [ion binding]; other site 216432004804 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216432004805 synthetase active site [active] 216432004806 NTP binding site [chemical binding]; other site 216432004807 metal binding site [ion binding]; metal-binding site 216432004808 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 216432004809 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216432004810 Peptidase family M48; Region: Peptidase_M48; pfam01435 216432004811 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216432004812 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 216432004813 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216432004814 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216432004815 metal ion-dependent adhesion site (MIDAS); other site 216432004816 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 216432004817 A new structural DNA glycosylase; Region: AlkD_like; cl11434 216432004818 active site 216432004819 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432004820 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216432004821 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216432004822 ATP binding site [chemical binding]; other site 216432004823 Mg++ binding site [ion binding]; other site 216432004824 motif III; other site 216432004825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432004826 nucleotide binding region [chemical binding]; other site 216432004827 ATP-binding site [chemical binding]; other site 216432004828 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 216432004829 RNA binding site [nucleotide binding]; other site 216432004830 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 216432004831 active site 216432004832 dimerization interface [polypeptide binding]; other site 216432004833 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 216432004834 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 216432004835 putative tRNA-binding site [nucleotide binding]; other site 216432004836 B3/4 domain; Region: B3_4; pfam03483 216432004837 tRNA synthetase B5 domain; Region: B5; pfam03484 216432004838 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 216432004839 dimer interface [polypeptide binding]; other site 216432004840 motif 1; other site 216432004841 motif 3; other site 216432004842 motif 2; other site 216432004843 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 216432004844 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 216432004845 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216432004846 Protein of unknown function, DUF479; Region: DUF479; pfam04336 216432004847 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 216432004848 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 216432004849 active site 216432004850 substrate binding site [chemical binding]; other site 216432004851 metal binding site [ion binding]; metal-binding site 216432004852 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 216432004853 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216432004854 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216432004855 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216432004856 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216432004857 catalytic core [active] 216432004858 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216432004859 CsbD-like; Region: CsbD; pfam05532 216432004860 Predicted acyl esterases [General function prediction only]; Region: COG2936 216432004861 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 216432004862 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 216432004863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 216432004864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432004865 binding surface 216432004866 TPR motif; other site 216432004867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216432004868 Histidine kinase; Region: HisKA_3; pfam07730 216432004869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432004870 ATP binding site [chemical binding]; other site 216432004871 Mg2+ binding site [ion binding]; other site 216432004872 G-X-G motif; other site 216432004873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216432004874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432004875 active site 216432004876 phosphorylation site [posttranslational modification] 216432004877 intermolecular recognition site; other site 216432004878 dimerization interface [polypeptide binding]; other site 216432004879 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 216432004880 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216432004881 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 216432004882 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 216432004883 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 216432004884 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 216432004885 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216432004886 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 216432004887 putative active site [active] 216432004888 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216432004889 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 216432004890 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 216432004891 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 216432004892 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 216432004893 NAD(P) binding site [chemical binding]; other site 216432004894 catalytic residues [active] 216432004895 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 216432004896 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 216432004897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216432004898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216432004899 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 216432004900 dimerization interface [polypeptide binding]; other site 216432004901 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 216432004902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432004903 TIGR01777 family protein; Region: yfcH 216432004904 NAD(P) binding site [chemical binding]; other site 216432004905 active site 216432004906 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 216432004907 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 216432004908 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 216432004909 metal binding site [ion binding]; metal-binding site 216432004910 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 216432004911 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 216432004912 substrate binding site [chemical binding]; other site 216432004913 glutamase interaction surface [polypeptide binding]; other site 216432004914 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 216432004915 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 216432004916 catalytic residues [active] 216432004917 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 216432004918 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 216432004919 putative active site [active] 216432004920 oxyanion strand; other site 216432004921 catalytic triad [active] 216432004922 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 216432004923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216432004924 active site 216432004925 motif I; other site 216432004926 motif II; other site 216432004927 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 216432004928 putative active site pocket [active] 216432004929 4-fold oligomerization interface [polypeptide binding]; other site 216432004930 metal binding residues [ion binding]; metal-binding site 216432004931 3-fold/trimer interface [polypeptide binding]; other site 216432004932 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 216432004933 GIY-YIG motif/motif A; other site 216432004934 putative active site [active] 216432004935 putative metal binding site [ion binding]; other site 216432004936 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 216432004937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216432004938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004939 homodimer interface [polypeptide binding]; other site 216432004940 catalytic residue [active] 216432004941 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 216432004942 histidinol dehydrogenase; Region: hisD; TIGR00069 216432004943 NAD binding site [chemical binding]; other site 216432004944 dimerization interface [polypeptide binding]; other site 216432004945 product binding site; other site 216432004946 substrate binding site [chemical binding]; other site 216432004947 zinc binding site [ion binding]; other site 216432004948 catalytic residues [active] 216432004949 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 216432004950 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 216432004951 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 216432004952 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432004953 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432004954 ligand binding site [chemical binding]; other site 216432004955 Uncharacterized conserved protein [Function unknown]; Region: COG3743 216432004956 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216432004957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432004958 Coenzyme A binding pocket [chemical binding]; other site 216432004959 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 216432004960 putative active site [active] 216432004961 putative metal binding site [ion binding]; other site 216432004962 imidazolonepropionase; Validated; Region: PRK09356 216432004963 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 216432004964 active site 216432004965 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 216432004966 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216432004967 homodimer interface [polypeptide binding]; other site 216432004968 substrate-cofactor binding pocket; other site 216432004969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432004970 catalytic residue [active] 216432004971 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 216432004972 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 216432004973 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 216432004974 active site 216432004975 Zn binding site [ion binding]; other site 216432004976 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 216432004977 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432004978 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216432004979 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216432004980 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216432004981 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 216432004982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 216432004983 FeS/SAM binding site; other site 216432004984 Predicted acetyltransferase [General function prediction only]; Region: COG2388 216432004985 Pirin; Region: Pirin; pfam02678 216432004986 Pirin-related protein [General function prediction only]; Region: COG1741 216432004987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432004988 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216432004989 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 216432004990 SmpB-tmRNA interface; other site 216432004991 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 216432004992 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 216432004993 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 216432004994 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 216432004995 nucleotide binding region [chemical binding]; other site 216432004996 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216432004997 ATP-binding site [chemical binding]; other site 216432004998 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216432004999 Cation efflux family; Region: Cation_efflux; pfam01545 216432005000 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 216432005001 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 216432005002 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432005003 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216432005004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432005005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432005006 DNA binding residues [nucleotide binding] 216432005007 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 216432005008 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 216432005009 membrane ATPase/protein kinase; Provisional; Region: PRK09435 216432005010 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 216432005011 GTP/Mg2+ binding site [chemical binding]; other site 216432005012 G5 box; other site 216432005013 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 216432005014 Walker A; other site 216432005015 G1 box; other site 216432005016 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216432005017 G4 box; other site 216432005018 G5 box; other site 216432005019 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 216432005020 active site 216432005021 multidrug efflux protein; Reviewed; Region: PRK01766 216432005022 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 216432005023 cation binding site [ion binding]; other site 216432005024 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216432005025 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 216432005026 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 216432005027 Leucine-rich repeats; other site 216432005028 Leucine rich repeat; Region: LRR_8; pfam13855 216432005029 Substrate binding site [chemical binding]; other site 216432005030 Leucine rich repeat; Region: LRR_8; pfam13855 216432005031 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 216432005032 Leucine rich repeat; Region: LRR_8; pfam13855 216432005033 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 216432005034 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005035 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 216432005036 PCRF domain; Region: PCRF; pfam03462 216432005037 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 216432005038 RF-1 domain; Region: RF-1; pfam00472 216432005039 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 216432005040 ArsC family; Region: ArsC; pfam03960 216432005041 catalytic residues [active] 216432005042 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432005043 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432005044 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216432005045 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216432005046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 216432005047 dimer interface [polypeptide binding]; other site 216432005048 active site 216432005049 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216432005050 folate binding site [chemical binding]; other site 216432005051 fumarylacetoacetase; Region: PLN02856 216432005052 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 216432005053 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216432005054 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 216432005055 heterodimerization interface [polypeptide binding]; other site 216432005056 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 216432005057 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005058 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 216432005059 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216432005060 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216432005061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432005062 Walker A/P-loop; other site 216432005063 ATP binding site [chemical binding]; other site 216432005064 Q-loop/lid; other site 216432005065 ABC transporter signature motif; other site 216432005066 Walker B; other site 216432005067 D-loop; other site 216432005068 H-loop/switch region; other site 216432005069 RNA polymerase sigma factor; Provisional; Region: PRK12513 216432005070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432005071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432005072 DNA binding residues [nucleotide binding] 216432005073 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216432005074 endonuclease III; Region: ENDO3c; smart00478 216432005075 minor groove reading motif; other site 216432005076 helix-hairpin-helix signature motif; other site 216432005077 substrate binding pocket [chemical binding]; other site 216432005078 active site 216432005079 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 216432005080 Integral membrane protein DUF95; Region: DUF95; pfam01944 216432005081 RDD family; Region: RDD; pfam06271 216432005082 UPF0126 domain; Region: UPF0126; pfam03458 216432005083 Predicted membrane protein [Function unknown]; Region: COG2860 216432005084 UPF0126 domain; Region: UPF0126; pfam03458 216432005085 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216432005086 active site 216432005087 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 216432005088 putative active site [active] 216432005089 putative CoA binding site [chemical binding]; other site 216432005090 nudix motif; other site 216432005091 metal binding site [ion binding]; metal-binding site 216432005092 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216432005093 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216432005094 putative acyl-acceptor binding pocket; other site 216432005095 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216432005096 TLC ATP/ADP transporter; Region: TLC; cl03940 216432005097 TLC ATP/ADP transporter; Region: TLC; cl03940 216432005098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216432005099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216432005100 active site 216432005101 metal binding site [ion binding]; metal-binding site 216432005102 Predicted transcriptional regulators [Transcription]; Region: COG1733 216432005103 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216432005104 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216432005105 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 216432005106 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 216432005107 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 216432005108 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216432005109 NAD(P) binding site [chemical binding]; other site 216432005110 putative active site [active] 216432005111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432005112 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 216432005113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216432005114 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216432005115 ATP binding site [chemical binding]; other site 216432005116 Mg++ binding site [ion binding]; other site 216432005117 motif III; other site 216432005118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432005119 nucleotide binding region [chemical binding]; other site 216432005120 ATP-binding site [chemical binding]; other site 216432005121 Flagellin N-methylase; Region: FliB; pfam03692 216432005122 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432005123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432005124 S-adenosylmethionine binding site [chemical binding]; other site 216432005125 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 216432005126 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216432005127 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 216432005128 active site 216432005129 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 216432005130 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216432005131 inhibitor-cofactor binding pocket; inhibition site 216432005132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432005133 catalytic residue [active] 216432005134 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 216432005135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432005136 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 216432005137 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216432005138 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216432005139 trimer interface [polypeptide binding]; other site 216432005140 active site 216432005141 substrate binding site [chemical binding]; other site 216432005142 CoA binding site [chemical binding]; other site 216432005143 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 216432005144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432005145 S-adenosylmethionine binding site [chemical binding]; other site 216432005146 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 216432005147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432005148 Coenzyme A binding pocket [chemical binding]; other site 216432005149 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 216432005150 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 216432005151 nucleotide binding pocket [chemical binding]; other site 216432005152 K-X-D-G motif; other site 216432005153 catalytic site [active] 216432005154 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216432005155 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 216432005156 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 216432005157 Dimer interface [polypeptide binding]; other site 216432005158 BRCT sequence motif; other site 216432005159 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 216432005160 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216432005161 dihydrodipicolinate synthase; Region: dapA; TIGR00674 216432005162 dimer interface [polypeptide binding]; other site 216432005163 active site 216432005164 catalytic residue [active] 216432005165 Outer membrane lipoprotein; Region: YfiO; pfam13525 216432005166 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 216432005167 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 216432005168 Flavoprotein; Region: Flavoprotein; pfam02441 216432005169 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 216432005170 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 216432005171 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216432005172 Walker A/P-loop; other site 216432005173 ATP binding site [chemical binding]; other site 216432005174 Q-loop/lid; other site 216432005175 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216432005176 ABC transporter signature motif; other site 216432005177 Walker B; other site 216432005178 D-loop; other site 216432005179 H-loop/switch region; other site 216432005180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432005181 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 216432005182 NAD(P) binding site [chemical binding]; other site 216432005183 active site 216432005184 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216432005185 Interdomain contacts; other site 216432005186 Cytokine receptor motif; other site 216432005187 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216432005188 Interdomain contacts; other site 216432005189 Cytokine receptor motif; other site 216432005190 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216432005191 Interdomain contacts; other site 216432005192 Cytokine receptor motif; other site 216432005193 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005194 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 216432005195 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216432005196 active site 216432005197 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 216432005198 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 216432005199 CoA-binding site [chemical binding]; other site 216432005200 ATP-binding [chemical binding]; other site 216432005201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432005202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432005203 dimer interface [polypeptide binding]; other site 216432005204 phosphorylation site [posttranslational modification] 216432005205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432005206 ATP binding site [chemical binding]; other site 216432005207 Mg2+ binding site [ion binding]; other site 216432005208 G-X-G motif; other site 216432005209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216432005210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432005211 active site 216432005212 phosphorylation site [posttranslational modification] 216432005213 intermolecular recognition site; other site 216432005214 dimerization interface [polypeptide binding]; other site 216432005215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 216432005216 DNA binding site [nucleotide binding] 216432005217 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 216432005218 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 216432005219 Ion transport protein; Region: Ion_trans; pfam00520 216432005220 Ion channel; Region: Ion_trans_2; pfam07885 216432005221 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 216432005222 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216432005223 active site 216432005224 catalytic site [active] 216432005225 substrate binding site [chemical binding]; other site 216432005226 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216432005227 GIY-YIG motif/motif A; other site 216432005228 active site 216432005229 catalytic site [active] 216432005230 putative DNA binding site [nucleotide binding]; other site 216432005231 metal binding site [ion binding]; metal-binding site 216432005232 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 216432005233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216432005234 catalytic residue [active] 216432005235 Uncharacterized conserved protein [Function unknown]; Region: COG4198 216432005236 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 216432005237 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 216432005238 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216432005239 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216432005240 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216432005241 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216432005242 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 216432005243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432005244 S-adenosylmethionine binding site [chemical binding]; other site 216432005245 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 216432005246 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216432005247 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216432005248 PspC domain; Region: PspC; pfam04024 216432005249 Predicted transcriptional regulators [Transcription]; Region: COG1695 216432005250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432005251 putative Zn2+ binding site [ion binding]; other site 216432005252 putative DNA binding site [nucleotide binding]; other site 216432005253 putative hydrolase; Provisional; Region: PRK02113 216432005254 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 216432005255 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216432005256 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 216432005257 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 216432005258 hinge; other site 216432005259 active site 216432005260 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 216432005261 Protein of unknown function (DUF493); Region: DUF493; pfam04359 216432005262 Predicted ATPase [General function prediction only]; Region: COG3911 216432005263 AAA domain; Region: AAA_28; pfam13521 216432005264 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 216432005265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432005266 ATP binding site [chemical binding]; other site 216432005267 putative Mg++ binding site [ion binding]; other site 216432005268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432005269 nucleotide binding region [chemical binding]; other site 216432005270 ATP-binding site [chemical binding]; other site 216432005271 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 216432005272 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 216432005273 putative active site [active] 216432005274 substrate binding site [chemical binding]; other site 216432005275 putative cosubstrate binding site; other site 216432005276 catalytic site [active] 216432005277 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 216432005278 substrate binding site [chemical binding]; other site 216432005279 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216432005280 IHF dimer interface [polypeptide binding]; other site 216432005281 IHF - DNA interface [nucleotide binding]; other site 216432005282 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 216432005283 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 216432005284 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 216432005285 homodimer interface [polypeptide binding]; other site 216432005286 substrate-cofactor binding pocket; other site 216432005287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432005288 catalytic residue [active] 216432005289 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216432005290 hydrophobic ligand binding site; other site 216432005291 carotene isomerase; Region: carot_isom; TIGR02730 216432005292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216432005293 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 216432005294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432005295 Coenzyme A binding pocket [chemical binding]; other site 216432005296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432005297 Coenzyme A binding pocket [chemical binding]; other site 216432005298 Clp protease; Region: CLP_protease; pfam00574 216432005299 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216432005300 oligomer interface [polypeptide binding]; other site 216432005301 active site residues [active] 216432005302 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216432005303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432005304 Coenzyme A binding pocket [chemical binding]; other site 216432005305 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 216432005306 glutaminase; Provisional; Region: PRK00971 216432005307 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 216432005308 active site pocket [active] 216432005309 oxyanion hole [active] 216432005310 catalytic triad [active] 216432005311 active site nucleophile [active] 216432005312 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432005313 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432005314 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216432005315 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 216432005316 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 216432005317 Catalytic dyad [active] 216432005318 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216432005319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432005320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432005321 DNA binding residues [nucleotide binding] 216432005322 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 216432005323 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 216432005324 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 216432005325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432005326 ATP binding site [chemical binding]; other site 216432005327 Mg2+ binding site [ion binding]; other site 216432005328 G-X-G motif; other site 216432005329 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 216432005330 ATP binding site [chemical binding]; other site 216432005331 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 216432005332 active site 216432005333 putative metal-binding site [ion binding]; other site 216432005334 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216432005335 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 216432005336 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 216432005337 CAP-like domain; other site 216432005338 active site 216432005339 primary dimer interface [polypeptide binding]; other site 216432005340 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 216432005341 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 216432005342 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 216432005343 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 216432005344 active site 216432005345 DNA binding site [nucleotide binding] 216432005346 Int/Topo IB signature motif; other site 216432005347 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 216432005348 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 216432005349 oligomer interface [polypeptide binding]; other site 216432005350 active site 216432005351 metal binding site [ion binding]; metal-binding site 216432005352 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 216432005353 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 216432005354 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 216432005355 putative active site [active] 216432005356 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 216432005357 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432005358 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432005359 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432005360 recombination protein F; Reviewed; Region: recF; PRK00064 216432005361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432005362 Walker A/P-loop; other site 216432005363 ATP binding site [chemical binding]; other site 216432005364 Q-loop/lid; other site 216432005365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432005366 ABC transporter signature motif; other site 216432005367 Walker B; other site 216432005368 D-loop; other site 216432005369 H-loop/switch region; other site 216432005370 Protein of unknown function (DUF1101); Region: DUF1101; pfam06503 216432005371 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 216432005372 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 216432005373 homopentamer interface [polypeptide binding]; other site 216432005374 active site 216432005375 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 216432005376 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216432005377 Protein of unknown function DUF58; Region: DUF58; pfam01882 216432005378 MoxR-like ATPases [General function prediction only]; Region: COG0714 216432005379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432005380 Walker A motif; other site 216432005381 ATP binding site [chemical binding]; other site 216432005382 Walker B motif; other site 216432005383 arginine finger; other site 216432005384 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216432005385 Uncharacterized conserved protein [Function unknown]; Region: COG5495 216432005386 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 216432005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432005388 putative substrate translocation pore; other site 216432005389 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 216432005390 active site 216432005391 dinuclear metal binding site [ion binding]; other site 216432005392 dimerization interface [polypeptide binding]; other site 216432005393 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 216432005394 fumarate hydratase; Reviewed; Region: fumC; PRK00485 216432005395 Class II fumarases; Region: Fumarase_classII; cd01362 216432005396 active site 216432005397 tetramer interface [polypeptide binding]; other site 216432005398 GTP-binding protein YchF; Reviewed; Region: PRK09601 216432005399 YchF GTPase; Region: YchF; cd01900 216432005400 G1 box; other site 216432005401 GTP/Mg2+ binding site [chemical binding]; other site 216432005402 Switch I region; other site 216432005403 G2 box; other site 216432005404 Switch II region; other site 216432005405 G3 box; other site 216432005406 G4 box; other site 216432005407 G5 box; other site 216432005408 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 216432005409 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 216432005410 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216432005411 ATP binding site [chemical binding]; other site 216432005412 Mg++ binding site [ion binding]; other site 216432005413 motif III; other site 216432005414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432005415 nucleotide binding region [chemical binding]; other site 216432005416 ATP-binding site [chemical binding]; other site 216432005417 Predicted flavoprotein [General function prediction only]; Region: COG0431 216432005418 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216432005419 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 216432005420 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216432005421 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 216432005422 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 216432005423 Ligand Binding Site [chemical binding]; other site 216432005424 TilS substrate C-terminal domain; Region: TilS_C; smart00977 216432005425 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 216432005426 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 216432005427 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 216432005428 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 216432005429 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 216432005430 Clp amino terminal domain; Region: Clp_N; pfam02861 216432005431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432005432 Walker A motif; other site 216432005433 ATP binding site [chemical binding]; other site 216432005434 Walker B motif; other site 216432005435 arginine finger; other site 216432005436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432005437 Walker A motif; other site 216432005438 ATP binding site [chemical binding]; other site 216432005439 Walker B motif; other site 216432005440 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216432005441 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 216432005442 Found in ATP-dependent protease La (LON); Region: LON; smart00464 216432005443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432005444 Walker A motif; other site 216432005445 ATP binding site [chemical binding]; other site 216432005446 Walker B motif; other site 216432005447 arginine finger; other site 216432005448 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216432005449 Predicted esterase [General function prediction only]; Region: COG0400 216432005450 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216432005451 CoenzymeA binding site [chemical binding]; other site 216432005452 subunit interaction site [polypeptide binding]; other site 216432005453 PHB binding site; other site 216432005454 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216432005455 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216432005456 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216432005457 D-glutamate deacylase; Validated; Region: PRK09061 216432005458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432005459 active site 216432005460 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432005461 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432005462 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 216432005463 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 216432005464 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432005465 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432005466 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216432005467 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005468 V-type ATP synthase subunit I; Validated; Region: PRK05771 216432005469 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 216432005470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432005471 primosomal protein N' Region: priA; TIGR00595 216432005472 ATP binding site [chemical binding]; other site 216432005473 putative Mg++ binding site [ion binding]; other site 216432005474 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216432005475 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216432005476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432005477 active site 216432005478 phosphorylation site [posttranslational modification] 216432005479 intermolecular recognition site; other site 216432005480 dimerization interface [polypeptide binding]; other site 216432005481 LytTr DNA-binding domain; Region: LytTR; smart00850 216432005482 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 216432005483 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 216432005484 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 216432005485 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 216432005486 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 216432005487 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 216432005488 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 216432005489 active site 216432005490 FMN binding site [chemical binding]; other site 216432005491 substrate binding site [chemical binding]; other site 216432005492 3Fe-4S cluster binding site [ion binding]; other site 216432005493 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 216432005494 Part of AAA domain; Region: AAA_19; pfam13245 216432005495 Family description; Region: UvrD_C_2; pfam13538 216432005496 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 216432005497 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 216432005498 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 216432005499 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 216432005500 Zn binding site [ion binding]; other site 216432005501 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 216432005502 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 216432005503 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216432005504 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216432005505 putative NAD(P) binding site [chemical binding]; other site 216432005506 putative substrate binding site [chemical binding]; other site 216432005507 catalytic Zn binding site [ion binding]; other site 216432005508 structural Zn binding site [ion binding]; other site 216432005509 dimer interface [polypeptide binding]; other site 216432005510 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 216432005511 EamA-like transporter family; Region: EamA; pfam00892 216432005512 enterobactin exporter EntS; Provisional; Region: PRK10489 216432005513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432005514 putative substrate translocation pore; other site 216432005515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216432005516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216432005517 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 216432005518 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216432005519 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216432005520 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216432005521 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432005522 pyruvate carboxylase; Reviewed; Region: PRK12999 216432005523 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216432005524 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216432005525 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216432005526 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 216432005527 active site 216432005528 catalytic residues [active] 216432005529 metal binding site [ion binding]; metal-binding site 216432005530 homodimer binding site [polypeptide binding]; other site 216432005531 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216432005532 carboxyltransferase (CT) interaction site; other site 216432005533 biotinylation site [posttranslational modification]; other site 216432005534 Helix-turn-helix domain; Region: HTH_18; pfam12833 216432005535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216432005536 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216432005537 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 216432005538 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 216432005539 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216432005540 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 216432005541 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 216432005542 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216432005543 potential catalytic triad [active] 216432005544 conserved cys residue [active] 216432005545 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 216432005546 dimer interface [polypeptide binding]; other site 216432005547 FMN binding site [chemical binding]; other site 216432005548 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216432005549 YceI-like domain; Region: YceI; pfam04264 216432005550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216432005551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216432005552 DNA binding site [nucleotide binding] 216432005553 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 216432005554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 216432005555 ATP binding site [chemical binding]; other site 216432005556 putative Mg++ binding site [ion binding]; other site 216432005557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432005558 nucleotide binding region [chemical binding]; other site 216432005559 ATP-binding site [chemical binding]; other site 216432005560 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 216432005561 RNA binding site [nucleotide binding]; other site 216432005562 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216432005563 HSP70 interaction site [polypeptide binding]; other site 216432005564 KTSC domain; Region: KTSC; pfam13619 216432005565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432005566 NAD(P) binding site [chemical binding]; other site 216432005567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432005568 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216432005569 active site 216432005570 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 216432005571 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216432005572 Di-iron ligands [ion binding]; other site 216432005573 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 216432005574 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216432005575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216432005576 ligand binding site [chemical binding]; other site 216432005577 Predicted transcriptional regulators [Transcription]; Region: COG1733 216432005578 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216432005579 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 216432005580 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 216432005581 putative NAD(P) binding site [chemical binding]; other site 216432005582 dimer interface [polypeptide binding]; other site 216432005583 Cupin domain; Region: Cupin_2; cl17218 216432005584 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216432005585 Helix-turn-helix domain; Region: HTH_18; pfam12833 216432005586 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216432005587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216432005588 substrate binding site [chemical binding]; other site 216432005589 oxyanion hole (OAH) forming residues; other site 216432005590 trimer interface [polypeptide binding]; other site 216432005591 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 216432005592 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216432005593 putative NAD(P) binding site [chemical binding]; other site 216432005594 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 216432005595 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216432005596 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 216432005597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432005598 NAD(P) binding site [chemical binding]; other site 216432005599 active site 216432005600 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 216432005601 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 216432005602 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 216432005603 TrkA-N domain; Region: TrkA_N; pfam02254 216432005604 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 216432005605 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 216432005606 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 216432005607 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 216432005608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432005609 putative substrate translocation pore; other site 216432005610 Protein of unknown function DUF72; Region: DUF72; pfam01904 216432005611 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 216432005612 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216432005613 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432005614 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216432005615 putative catalytic site [active] 216432005616 putative metal binding site [ion binding]; other site 216432005617 putative phosphate binding site [ion binding]; other site 216432005618 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216432005619 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432005620 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 216432005621 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 216432005622 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 216432005623 hexamer interface [polypeptide binding]; other site 216432005624 ligand binding site [chemical binding]; other site 216432005625 putative active site [active] 216432005626 NAD(P) binding site [chemical binding]; other site 216432005627 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 216432005628 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216432005629 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432005630 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432005631 DNA binding residues [nucleotide binding] 216432005632 Ycf48-like protein; Provisional; Region: PRK13684 216432005633 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 216432005634 16S rRNA methyltransferase B; Provisional; Region: PRK14902 216432005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432005636 S-adenosylmethionine binding site [chemical binding]; other site 216432005637 Endonuclease I; Region: Endonuclease_1; pfam04231 216432005638 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005639 ribonuclease Z; Reviewed; Region: PRK00055 216432005640 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 216432005641 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216432005642 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216432005643 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 216432005644 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432005645 active site 216432005646 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 216432005647 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 216432005648 RNA binding site [nucleotide binding]; other site 216432005649 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 216432005650 RNA binding site [nucleotide binding]; other site 216432005651 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216432005652 RNA binding site [nucleotide binding]; other site 216432005653 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216432005654 RNA binding site [nucleotide binding]; other site 216432005655 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216432005656 RNA binding site [nucleotide binding]; other site 216432005657 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 216432005658 RNA binding site [nucleotide binding]; other site 216432005659 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005660 cytidylate kinase; Provisional; Region: cmk; PRK00023 216432005661 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 216432005662 CMP-binding site; other site 216432005663 The sites determining sugar specificity; other site 216432005664 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 216432005665 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 216432005666 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 216432005667 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216432005668 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216432005669 FtsX-like permease family; Region: FtsX; pfam02687 216432005670 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 216432005671 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 216432005672 dimer interface [polypeptide binding]; other site 216432005673 motif 1; other site 216432005674 active site 216432005675 motif 2; other site 216432005676 motif 3; other site 216432005677 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 216432005678 anticodon binding site; other site 216432005679 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 216432005680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216432005681 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 216432005682 pseudouridine synthase; Region: TIGR00093 216432005683 active site 216432005684 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 216432005685 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216432005686 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 216432005687 active site clefts [active] 216432005688 zinc binding site [ion binding]; other site 216432005689 dimer interface [polypeptide binding]; other site 216432005690 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 216432005691 intracellular protease, PfpI family; Region: PfpI; TIGR01382 216432005692 proposed catalytic triad [active] 216432005693 conserved cys residue [active] 216432005694 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 216432005695 DinB superfamily; Region: DinB_2; pfam12867 216432005696 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 216432005697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432005698 putative DNA binding site [nucleotide binding]; other site 216432005699 putative Zn2+ binding site [ion binding]; other site 216432005700 AsnC family; Region: AsnC_trans_reg; pfam01037 216432005701 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 216432005702 putative active site [active] 216432005703 Zn binding site [ion binding]; other site 216432005704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432005705 non-specific DNA binding site [nucleotide binding]; other site 216432005706 salt bridge; other site 216432005707 sequence-specific DNA binding site [nucleotide binding]; other site 216432005708 Cupin domain; Region: Cupin_2; cl17218 216432005709 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216432005710 Active site serine [active] 216432005711 Patatin-like phospholipase; Region: Patatin; pfam01734 216432005712 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 216432005713 Zn binding site [ion binding]; other site 216432005714 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 216432005715 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 216432005716 generic binding surface II; other site 216432005717 ssDNA binding site; other site 216432005718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432005719 ATP binding site [chemical binding]; other site 216432005720 putative Mg++ binding site [ion binding]; other site 216432005721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432005722 nucleotide binding region [chemical binding]; other site 216432005723 ATP-binding site [chemical binding]; other site 216432005724 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 216432005725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216432005726 motif II; other site 216432005727 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216432005728 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 216432005729 NAD(P) binding site [chemical binding]; other site 216432005730 catalytic residues [active] 216432005731 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216432005732 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216432005733 FMN binding site [chemical binding]; other site 216432005734 active site 216432005735 substrate binding site [chemical binding]; other site 216432005736 catalytic residue [active] 216432005737 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216432005738 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216432005739 ligand binding site [chemical binding]; other site 216432005740 flexible hinge region; other site 216432005741 Integral membrane protein TerC family; Region: TerC; pfam03741 216432005742 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 216432005743 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 216432005744 30S subunit binding site; other site 216432005745 ArsC family; Region: ArsC; pfam03960 216432005746 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216432005747 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216432005748 tetramer interface [polypeptide binding]; other site 216432005749 TPP-binding site [chemical binding]; other site 216432005750 heterodimer interface [polypeptide binding]; other site 216432005751 phosphorylation loop region [posttranslational modification] 216432005752 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 216432005753 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216432005754 PYR/PP interface [polypeptide binding]; other site 216432005755 dimer interface [polypeptide binding]; other site 216432005756 TPP binding site [chemical binding]; other site 216432005757 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216432005758 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216432005759 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 216432005760 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432005761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216432005762 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 216432005763 substrate binding site [chemical binding]; other site 216432005764 oxyanion hole (OAH) forming residues; other site 216432005765 trimer interface [polypeptide binding]; other site 216432005766 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 216432005767 active site 216432005768 Proline dehydrogenase; Region: Pro_dh; cl03282 216432005769 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 216432005770 active site 216432005771 dimer interface [polypeptide binding]; other site 216432005772 metal binding site [ion binding]; metal-binding site 216432005773 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432005774 GLPGLI family protein; Region: GLPGLI; TIGR01200 216432005775 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 216432005776 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 216432005777 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 216432005778 Ligand binding site; other site 216432005779 oligomer interface; other site 216432005780 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 216432005781 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 216432005782 active site 216432005783 NAD binding site [chemical binding]; other site 216432005784 metal binding site [ion binding]; metal-binding site 216432005785 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 216432005786 AAA domain; Region: AAA_30; pfam13604 216432005787 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 216432005788 Family description; Region: UvrD_C_2; pfam13538 216432005789 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 216432005790 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 216432005791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432005792 S-adenosylmethionine binding site [chemical binding]; other site 216432005793 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216432005794 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 216432005795 oligomer interface [polypeptide binding]; other site 216432005796 metal binding site [ion binding]; metal-binding site 216432005797 metal binding site [ion binding]; metal-binding site 216432005798 Cl binding site [ion binding]; other site 216432005799 aspartate ring; other site 216432005800 basic sphincter; other site 216432005801 putative hydrophobic gate; other site 216432005802 periplasmic entrance; other site 216432005803 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 216432005804 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 216432005805 active site 216432005806 short chain dehydrogenase; Provisional; Region: PRK07326 216432005807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432005808 NAD(P) binding site [chemical binding]; other site 216432005809 active site 216432005810 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 216432005811 active site 216432005812 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 216432005813 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 216432005814 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 216432005815 putative metal binding site [ion binding]; other site 216432005816 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216432005817 Interdomain contacts; other site 216432005818 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 216432005819 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 216432005820 active site 216432005821 DNA binding site [nucleotide binding] 216432005822 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 216432005823 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 216432005824 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216432005825 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216432005826 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 216432005827 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 216432005828 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 216432005829 oligomerization interface [polypeptide binding]; other site 216432005830 active site 216432005831 metal binding site [ion binding]; metal-binding site 216432005832 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216432005833 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216432005834 active site 216432005835 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 216432005836 active site 216432005837 multimer interface [polypeptide binding]; other site 216432005838 DHH family; Region: DHH; pfam01368 216432005839 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 216432005840 DHHA1 domain; Region: DHHA1; pfam02272 216432005841 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 216432005842 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216432005843 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 216432005844 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216432005845 active site 216432005846 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216432005847 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 216432005848 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 216432005849 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 216432005850 Chain length determinant protein; Region: Wzz; pfam02706 216432005851 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 216432005852 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 216432005853 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216432005854 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 216432005855 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 216432005856 NAD(P) binding site [chemical binding]; other site 216432005857 homodimer interface [polypeptide binding]; other site 216432005858 substrate binding site [chemical binding]; other site 216432005859 active site 216432005860 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 216432005861 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216432005862 inhibitor-cofactor binding pocket; inhibition site 216432005863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432005864 catalytic residue [active] 216432005865 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216432005866 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432005867 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 216432005868 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 216432005869 active site 216432005870 intersubunit interactions; other site 216432005871 catalytic residue [active] 216432005872 short chain dehydrogenase; Validated; Region: PRK06182 216432005873 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216432005874 NADP binding site [chemical binding]; other site 216432005875 active site 216432005876 steroid binding site; other site 216432005877 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 216432005878 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432005879 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 216432005880 Protein of unknown function (DUF721); Region: DUF721; pfam05258 216432005881 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 216432005882 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 216432005883 dimer interface [polypeptide binding]; other site 216432005884 active site 216432005885 heme binding site [chemical binding]; other site 216432005886 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 216432005887 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 216432005888 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 216432005889 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 216432005890 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 216432005891 DXD motif; other site 216432005892 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 216432005893 substrate binding site [chemical binding]; other site 216432005894 dimer interface [polypeptide binding]; other site 216432005895 ATP binding site [chemical binding]; other site 216432005896 Putative transcription activator [Transcription]; Region: TenA; COG0819 216432005897 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 216432005898 thiamine phosphate binding site [chemical binding]; other site 216432005899 active site 216432005900 pyrophosphate binding site [ion binding]; other site 216432005901 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 216432005902 substrate binding site [chemical binding]; other site 216432005903 multimerization interface [polypeptide binding]; other site 216432005904 ATP binding site [chemical binding]; other site 216432005905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 216432005906 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 216432005907 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216432005908 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216432005909 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 216432005910 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 216432005911 putative FMN binding site [chemical binding]; other site 216432005912 acyl carrier protein; Provisional; Region: acpP; PRK00982 216432005913 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216432005914 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216432005915 dimer interface [polypeptide binding]; other site 216432005916 active site 216432005917 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216432005918 active site 2 [active] 216432005919 active site 1 [active] 216432005920 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 216432005921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432005922 NAD(P) binding site [chemical binding]; other site 216432005923 active site 216432005924 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 216432005925 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 216432005926 malonyl-CoA binding site [chemical binding]; other site 216432005927 dimer interface [polypeptide binding]; other site 216432005928 active site 216432005929 product binding site; other site 216432005930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216432005931 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 216432005932 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216432005933 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432005934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432005935 ligand binding site [chemical binding]; other site 216432005936 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 216432005937 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 216432005938 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216432005939 tetramer interface [polypeptide binding]; other site 216432005940 TPP-binding site [chemical binding]; other site 216432005941 heterodimer interface [polypeptide binding]; other site 216432005942 phosphorylation loop region [posttranslational modification] 216432005943 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216432005944 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216432005945 alpha subunit interface [polypeptide binding]; other site 216432005946 TPP binding site [chemical binding]; other site 216432005947 heterodimer interface [polypeptide binding]; other site 216432005948 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216432005949 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 216432005950 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 216432005951 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 216432005952 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 216432005953 putative rRNA binding site [nucleotide binding]; other site 216432005954 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 216432005955 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 216432005956 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 216432005957 polyphosphate kinase; Provisional; Region: PRK05443 216432005958 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 216432005959 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 216432005960 domain interface [polypeptide binding]; other site 216432005961 active site 216432005962 catalytic site [active] 216432005963 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 216432005964 domain interface [polypeptide binding]; other site 216432005965 active site 216432005966 catalytic site [active] 216432005967 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216432005968 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 216432005969 ligand binding site [chemical binding]; other site 216432005970 active site 216432005971 UGI interface [polypeptide binding]; other site 216432005972 catalytic site [active] 216432005973 MutS domain III; Region: MutS_III; pfam05192 216432005974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432005975 Walker A/P-loop; other site 216432005976 ATP binding site [chemical binding]; other site 216432005977 Q-loop/lid; other site 216432005978 ABC transporter signature motif; other site 216432005979 Walker B; other site 216432005980 D-loop; other site 216432005981 H-loop/switch region; other site 216432005982 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 216432005983 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 216432005984 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 216432005985 glutathione synthetase; Provisional; Region: PRK12458 216432005986 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 216432005987 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 216432005988 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216432005989 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216432005990 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 216432005991 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 216432005992 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 216432005993 Tetramer interface [polypeptide binding]; other site 216432005994 active site 216432005995 FMN-binding site [chemical binding]; other site 216432005996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216432005997 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216432005998 putative active site [active] 216432005999 putative metal binding site [ion binding]; other site 216432006000 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216432006001 FAD binding domain; Region: FAD_binding_4; pfam01565 216432006002 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216432006003 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 216432006004 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 216432006005 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216432006006 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 216432006007 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 216432006008 Beta-lactamase; Region: Beta-lactamase; cl17358 216432006009 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432006010 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216432006011 Cysteine-rich domain; Region: CCG; pfam02754 216432006012 Cysteine-rich domain; Region: CCG; pfam02754 216432006013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216432006014 active site 216432006015 motif I; other site 216432006016 motif II; other site 216432006017 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 216432006018 4Fe-4S binding domain; Region: Fer4; cl02805 216432006019 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 216432006020 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216432006021 mce related protein; Region: MCE; pfam02470 216432006022 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 216432006023 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216432006024 active site 216432006025 metal binding site [ion binding]; metal-binding site 216432006026 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 216432006027 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216432006028 homotrimer interaction site [polypeptide binding]; other site 216432006029 putative active site [active] 216432006030 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 216432006031 S1 domain; Region: S1_2; pfam13509 216432006032 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 216432006033 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 216432006034 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 216432006035 dimer interface [polypeptide binding]; other site 216432006036 tetramer interface [polypeptide binding]; other site 216432006037 PYR/PP interface [polypeptide binding]; other site 216432006038 TPP binding site [chemical binding]; other site 216432006039 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 216432006040 TPP-binding site; other site 216432006041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432006042 binding surface 216432006043 TPR motif; other site 216432006044 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216432006045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432006046 binding surface 216432006047 TPR motif; other site 216432006048 DNA gyrase subunit A; Validated; Region: PRK05560 216432006049 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 216432006050 CAP-like domain; other site 216432006051 active site 216432006052 primary dimer interface [polypeptide binding]; other site 216432006053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216432006054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216432006055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216432006056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216432006057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216432006058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216432006059 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 216432006060 Clp amino terminal domain; Region: Clp_N; pfam02861 216432006061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432006062 Walker A motif; other site 216432006063 ATP binding site [chemical binding]; other site 216432006064 Walker B motif; other site 216432006065 arginine finger; other site 216432006066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432006067 Walker A motif; other site 216432006068 ATP binding site [chemical binding]; other site 216432006069 Walker B motif; other site 216432006070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216432006071 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216432006072 active sites [active] 216432006073 tetramer interface [polypeptide binding]; other site 216432006074 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216432006075 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216432006076 putative carbohydrate kinase; Provisional; Region: PRK10565 216432006077 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 216432006078 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 216432006079 putative substrate binding site [chemical binding]; other site 216432006080 putative ATP binding site [chemical binding]; other site 216432006081 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 216432006082 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 216432006083 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216432006084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432006085 active site 216432006086 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 216432006087 aromatic arch; other site 216432006088 DCoH dimer interaction site [polypeptide binding]; other site 216432006089 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 216432006090 DCoH tetramer interaction site [polypeptide binding]; other site 216432006091 substrate binding site [chemical binding]; other site 216432006092 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216432006093 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432006094 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216432006095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432006096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432006097 DNA binding residues [nucleotide binding] 216432006098 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216432006099 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 216432006100 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 216432006101 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216432006102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216432006103 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 216432006104 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 216432006105 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216432006106 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216432006107 Ligand binding site; other site 216432006108 Putative Catalytic site; other site 216432006109 DXD motif; other site 216432006110 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 216432006111 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 216432006112 active site 216432006113 substrate binding site [chemical binding]; other site 216432006114 metal binding site [ion binding]; metal-binding site 216432006115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216432006116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216432006117 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 216432006118 Walker A/P-loop; other site 216432006119 ATP binding site [chemical binding]; other site 216432006120 Q-loop/lid; other site 216432006121 ABC transporter signature motif; other site 216432006122 Walker B; other site 216432006123 D-loop; other site 216432006124 H-loop/switch region; other site 216432006125 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 216432006126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216432006127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432006128 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216432006129 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216432006130 NAD(P) binding site [chemical binding]; other site 216432006131 substrate binding site [chemical binding]; other site 216432006132 dimer interface [polypeptide binding]; other site 216432006133 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 216432006134 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 216432006135 active site 216432006136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216432006137 Histidine kinase; Region: HisKA_2; pfam07568 216432006138 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 216432006139 ATP binding site [chemical binding]; other site 216432006140 Mg2+ binding site [ion binding]; other site 216432006141 G-X-G motif; other site 216432006142 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 216432006143 UbiA prenyltransferase family; Region: UbiA; pfam01040 216432006144 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 216432006145 DNA polymerase III, delta subunit; Region: holA; TIGR01128 216432006146 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 216432006147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216432006148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216432006149 active site 216432006150 catalytic tetrad [active] 216432006151 glucose-1-dehydrogenase; Provisional; Region: PRK08340 216432006152 classical (c) SDRs; Region: SDR_c; cd05233 216432006153 NAD(P) binding site [chemical binding]; other site 216432006154 active site 216432006155 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 216432006156 DNA photolyase; Region: DNA_photolyase; pfam00875 216432006157 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432006158 ligand binding site [chemical binding]; other site 216432006159 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 216432006160 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 216432006161 putative RNA binding site [nucleotide binding]; other site 216432006162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432006163 S-adenosylmethionine binding site [chemical binding]; other site 216432006164 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 216432006165 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216432006166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432006167 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216432006168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432006169 DNA binding residues [nucleotide binding] 216432006170 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 216432006171 active site 216432006172 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 216432006173 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 216432006174 active site 216432006175 dimer interface [polypeptide binding]; other site 216432006176 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432006177 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 216432006178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432006179 ATP binding site [chemical binding]; other site 216432006180 putative Mg++ binding site [ion binding]; other site 216432006181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432006182 nucleotide binding region [chemical binding]; other site 216432006183 ATP-binding site [chemical binding]; other site 216432006184 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216432006185 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216432006186 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216432006187 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216432006188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216432006189 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216432006190 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216432006191 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216432006192 carboxyltransferase (CT) interaction site; other site 216432006193 biotinylation site [posttranslational modification]; other site 216432006194 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 216432006195 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432006196 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 216432006197 Domain of unknown function (DUF305); Region: DUF305; cl17794 216432006198 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216432006199 metal-binding site [ion binding] 216432006200 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 216432006201 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216432006202 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216432006203 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 216432006204 Outer membrane efflux protein; Region: OEP; pfam02321 216432006205 Outer membrane efflux protein; Region: OEP; pfam02321 216432006206 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 216432006207 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 216432006208 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 216432006209 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 216432006210 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216432006211 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 216432006212 active site 216432006213 SdiA-regulated; Region: SdiA-regulated; pfam06977 216432006214 SdiA-regulated; Region: SdiA-regulated; cd09971 216432006215 putative active site [active] 216432006216 Predicted membrane protein [Function unknown]; Region: COG2323 216432006217 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 216432006218 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216432006219 dimer interface [polypeptide binding]; other site 216432006220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432006221 catalytic residue [active] 216432006222 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 216432006223 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 216432006224 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 216432006225 dimer interface [polypeptide binding]; other site 216432006226 active site 216432006227 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216432006228 catalytic residues [active] 216432006229 substrate binding site [chemical binding]; other site 216432006230 hydroperoxidase II; Provisional; Region: katE; PRK11249 216432006231 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 216432006232 tetramer interface [polypeptide binding]; other site 216432006233 heme binding pocket [chemical binding]; other site 216432006234 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 216432006235 domain interactions; other site 216432006236 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 216432006237 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216432006238 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 216432006239 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432006240 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216432006241 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216432006242 N-terminal plug; other site 216432006243 ligand-binding site [chemical binding]; other site 216432006244 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216432006245 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216432006246 DNA binding site [nucleotide binding] 216432006247 domain linker motif; other site 216432006248 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216432006249 dimerization interface [polypeptide binding]; other site 216432006250 ligand binding site [chemical binding]; other site 216432006251 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 216432006252 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216432006253 active site 216432006254 intersubunit interface [polypeptide binding]; other site 216432006255 catalytic residue [active] 216432006256 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216432006257 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216432006258 substrate binding site [chemical binding]; other site 216432006259 ATP binding site [chemical binding]; other site 216432006260 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216432006261 classical (c) SDRs; Region: SDR_c; cd05233 216432006262 NAD(P) binding site [chemical binding]; other site 216432006263 active site 216432006264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432006265 D-galactonate transporter; Region: 2A0114; TIGR00893 216432006266 putative substrate translocation pore; other site 216432006267 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216432006268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216432006269 DNA-binding site [nucleotide binding]; DNA binding site 216432006270 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216432006271 Alginate lyase; Region: Alginate_lyase2; pfam08787 216432006272 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 216432006273 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 216432006274 starch binding outer membrane protein SusD; Region: SusD; cd08977 216432006275 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 216432006276 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432006277 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 216432006278 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432006279 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216432006280 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 216432006281 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 216432006282 Alginate lyase; Region: Alginate_lyase2; pfam08787 216432006283 Alginate lyase; Region: Alginate_lyase2; pfam08787 216432006284 Response regulator receiver domain; Region: Response_reg; pfam00072 216432006285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432006286 active site 216432006287 phosphorylation site [posttranslational modification] 216432006288 intermolecular recognition site; other site 216432006289 dimerization interface [polypeptide binding]; other site 216432006290 Heme NO binding; Region: HNOB; pfam07700 216432006291 PAS domain; Region: PAS_9; pfam13426 216432006292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216432006293 putative active site [active] 216432006294 heme pocket [chemical binding]; other site 216432006295 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216432006296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216432006297 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216432006298 putative active site [active] 216432006299 heme pocket [chemical binding]; other site 216432006300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216432006301 putative active site [active] 216432006302 heme pocket [chemical binding]; other site 216432006303 GAF domain; Region: GAF; pfam01590 216432006304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432006305 dimer interface [polypeptide binding]; other site 216432006306 phosphorylation site [posttranslational modification] 216432006307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432006308 ATP binding site [chemical binding]; other site 216432006309 Mg2+ binding site [ion binding]; other site 216432006310 G-X-G motif; other site 216432006311 baseplate wedge subunit; Provisional; Region: 7; PHA02579 216432006312 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216432006313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432006314 active site 216432006315 phosphorylation site [posttranslational modification] 216432006316 intermolecular recognition site; other site 216432006317 dimerization interface [polypeptide binding]; other site 216432006318 LytTr DNA-binding domain; Region: LytTR; smart00850 216432006319 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216432006320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432006321 active site 216432006322 phosphorylation site [posttranslational modification] 216432006323 intermolecular recognition site; other site 216432006324 dimerization interface [polypeptide binding]; other site 216432006325 LytTr DNA-binding domain; Region: LytTR; smart00850 216432006326 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 216432006327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432006328 dimer interface [polypeptide binding]; other site 216432006329 phosphorylation site [posttranslational modification] 216432006330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432006331 ATP binding site [chemical binding]; other site 216432006332 Mg2+ binding site [ion binding]; other site 216432006333 G-X-G motif; other site 216432006334 Isochorismatase family; Region: Isochorismatase; pfam00857 216432006335 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216432006336 catalytic triad [active] 216432006337 conserved cis-peptide bond; other site 216432006338 RloB-like protein; Region: RloB; pfam13707 216432006339 AAA domain; Region: AAA_21; pfam13304 216432006340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432006341 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 216432006342 Walker A/P-loop; other site 216432006343 ATP binding site [chemical binding]; other site 216432006344 Helix-turn-helix domain; Region: HTH_36; pfam13730 216432006345 Helix-turn-helix domain; Region: HTH_17; pfam12728 216432006346 RteC protein; Region: RteC; pfam09357 216432006347 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 216432006348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216432006349 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216432006350 MerT mercuric transport protein; Region: MerT; cl03578 216432006351 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216432006352 metal-binding site [ion binding] 216432006353 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 216432006354 metal binding site 2 [ion binding]; metal-binding site 216432006355 putative DNA binding helix; other site 216432006356 metal binding site 1 [ion binding]; metal-binding site 216432006357 dimer interface [polypeptide binding]; other site 216432006358 structural Zn2+ binding site [ion binding]; other site 216432006359 Cation efflux family; Region: Cation_efflux; pfam01545 216432006360 HlyD family secretion protein; Region: HlyD_2; pfam12700 216432006361 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432006362 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 216432006363 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 216432006364 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216432006365 HlyD family secretion protein; Region: HlyD_3; pfam13437 216432006366 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 216432006367 Domain of unknown function (DUF305); Region: DUF305; cl17794 216432006368 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 216432006369 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 216432006370 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216432006371 metal-binding site [ion binding] 216432006372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216432006373 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216432006374 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216432006375 Predicted permease; Region: DUF318; cl17795 216432006376 Haem-binding domain; Region: Haem_bd; pfam14376 216432006377 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 216432006378 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216432006379 Multicopper oxidase; Region: Cu-oxidase; pfam00394 216432006380 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216432006381 Helix-turn-helix domain; Region: HTH_18; pfam12833 216432006382 Outer membrane efflux protein; Region: OEP; pfam02321 216432006383 Outer membrane efflux protein; Region: OEP; pfam02321 216432006384 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 216432006385 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 216432006386 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 216432006387 RteC protein; Region: RteC; pfam09357 216432006388 Predicted transporter component [General function prediction only]; Region: COG2391 216432006389 Sulphur transport; Region: Sulf_transp; pfam04143 216432006390 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 216432006391 Predicted transmembrane and coiled-coil 2 protein; Region: Tmemb_cc2; pfam10267 216432006392 DoxX; Region: DoxX; pfam07681 216432006393 DsrE/DsrF-like family; Region: DrsE; cl00672 216432006394 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 216432006395 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 216432006396 active site 216432006397 metal binding site [ion binding]; metal-binding site 216432006398 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216432006399 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432006400 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432006401 catalytic residues [active] 216432006402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216432006403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432006404 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432006405 active site residue [active] 216432006406 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432006407 active site residue [active] 216432006408 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216432006409 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216432006410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216432006411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216432006412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216432006413 ligand binding site [chemical binding]; other site 216432006414 flexible hinge region; other site 216432006415 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 216432006416 putative switch regulator; other site 216432006417 non-specific DNA interactions [nucleotide binding]; other site 216432006418 DNA binding site [nucleotide binding] 216432006419 sequence specific DNA binding site [nucleotide binding]; other site 216432006420 putative cAMP binding site [chemical binding]; other site 216432006421 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216432006422 active site 216432006423 DNA binding site [nucleotide binding] 216432006424 Int/Topo IB signature motif; other site 216432006425 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 216432006426 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 216432006427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432006428 Zn2+ binding site [ion binding]; other site 216432006429 Mg2+ binding site [ion binding]; other site 216432006430 acetyl-CoA C-acetyltransferase; Region: PLN02644 216432006431 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216432006432 dimer interface [polypeptide binding]; other site 216432006433 active site 216432006434 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216432006435 NlpC/P60 family; Region: NLPC_P60; pfam00877 216432006436 apocytochrome f; Reviewed; Region: PRK02693 216432006437 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 216432006438 Fasciclin domain; Region: Fasciclin; pfam02469 216432006439 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216432006440 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216432006441 Peptidase family M23; Region: Peptidase_M23; pfam01551 216432006442 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 216432006443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432006444 Walker A motif; other site 216432006445 ATP binding site [chemical binding]; other site 216432006446 Walker B motif; other site 216432006447 arginine finger; other site 216432006448 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 216432006449 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 216432006450 active site 216432006451 dinuclear metal binding site [ion binding]; other site 216432006452 dimerization interface [polypeptide binding]; other site 216432006453 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432006454 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216432006455 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 216432006456 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 216432006457 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 216432006458 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 216432006459 domain interface [polypeptide binding]; other site 216432006460 active site 216432006461 catalytic site [active] 216432006462 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 216432006463 domain interface [polypeptide binding]; other site 216432006464 active site 216432006465 catalytic site [active] 216432006466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216432006467 catalytic core [active] 216432006468 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 216432006469 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216432006470 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 216432006471 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 216432006472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432006473 Walker A/P-loop; other site 216432006474 ATP binding site [chemical binding]; other site 216432006475 Q-loop/lid; other site 216432006476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432006477 ABC transporter signature motif; other site 216432006478 Walker B; other site 216432006479 D-loop; other site 216432006480 H-loop/switch region; other site 216432006481 ABC transporter; Region: ABC_tran_2; pfam12848 216432006482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216432006483 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 216432006484 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 216432006485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216432006486 substrate binding pocket [chemical binding]; other site 216432006487 integral membrane protein; Region: integ_memb_HG; TIGR03954 216432006488 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216432006489 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 216432006490 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 216432006491 Ligand Binding Site [chemical binding]; other site 216432006492 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216432006493 Dehydroquinase class II; Region: DHquinase_II; pfam01220 216432006494 active site 216432006495 trimer interface [polypeptide binding]; other site 216432006496 dimer interface [polypeptide binding]; other site 216432006497 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432006498 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432006499 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 216432006500 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 216432006501 active site 216432006502 Int/Topo IB signature motif; other site 216432006503 2TM domain; Region: 2TM; pfam13239 216432006504 Histidine kinase; Region: His_kinase; pfam06580 216432006505 2TM domain; Region: 2TM; pfam13239 216432006506 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 216432006507 prenyltransferase; Reviewed; Region: ubiA; PRK12872 216432006508 UbiA prenyltransferase family; Region: UbiA; pfam01040 216432006509 Maf-like protein; Region: Maf; pfam02545 216432006510 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216432006511 active site 216432006512 dimer interface [polypeptide binding]; other site 216432006513 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216432006514 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432006515 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 216432006516 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 216432006517 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 216432006518 Na binding site [ion binding]; other site 216432006519 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 216432006520 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 216432006521 putative hydrophobic ligand binding site [chemical binding]; other site 216432006522 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216432006523 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 216432006524 PA/protease or protease-like domain interface [polypeptide binding]; other site 216432006525 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 216432006526 Peptidase family M28; Region: Peptidase_M28; pfam04389 216432006527 metal binding site [ion binding]; metal-binding site 216432006528 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 216432006529 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 216432006530 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 216432006531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432006532 FeS/SAM binding site; other site 216432006533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216432006534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216432006535 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216432006536 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 216432006537 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 216432006538 catalytic residues [active] 216432006539 phosphoglyceromutase; Provisional; Region: PRK05434 216432006540 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 216432006541 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216432006542 catalytic residues [active] 216432006543 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216432006544 active site 216432006545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216432006546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432006547 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 216432006548 ApbE family; Region: ApbE; pfam02424 216432006549 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 216432006550 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216432006551 catalytic loop [active] 216432006552 iron binding site [ion binding]; other site 216432006553 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 216432006554 FAD binding pocket [chemical binding]; other site 216432006555 FAD binding motif [chemical binding]; other site 216432006556 phosphate binding motif [ion binding]; other site 216432006557 beta-alpha-beta structure motif; other site 216432006558 NAD binding pocket [chemical binding]; other site 216432006559 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 216432006560 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 216432006561 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 216432006562 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 216432006563 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 216432006564 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 216432006565 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 216432006566 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216432006567 Double zinc ribbon; Region: DZR; pfam12773 216432006568 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 216432006569 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 216432006570 NRDE protein; Region: NRDE; cl01315 216432006571 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216432006572 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216432006573 active site 216432006574 metal binding site [ion binding]; metal-binding site 216432006575 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432006576 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 216432006577 E-class dimer interface [polypeptide binding]; other site 216432006578 P-class dimer interface [polypeptide binding]; other site 216432006579 active site 216432006580 Cu2+ binding site [ion binding]; other site 216432006581 Zn2+ binding site [ion binding]; other site 216432006582 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 216432006583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432006584 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216432006585 DNA binding residues [nucleotide binding] 216432006586 putative anti-sigmaE protein; Provisional; Region: PRK13920 216432006587 Anti-sigma-K factor rskA; Region: RskA; pfam10099 216432006588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216432006589 TPR motif; other site 216432006590 binding surface 216432006591 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 216432006592 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 216432006593 Cation transport protein; Region: TrkH; cl17365 216432006594 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 216432006595 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 216432006596 TrkA-N domain; Region: TrkA_N; pfam02254 216432006597 TrkA-C domain; Region: TrkA_C; pfam02080 216432006598 TrkA-N domain; Region: TrkA_N; pfam02254 216432006599 TrkA-C domain; Region: TrkA_C; pfam02080 216432006600 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 216432006601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432006602 S-adenosylmethionine binding site [chemical binding]; other site 216432006603 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 216432006604 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216432006605 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216432006606 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 216432006607 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432006608 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 216432006609 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 216432006610 active site 216432006611 intersubunit interface [polypeptide binding]; other site 216432006612 zinc binding site [ion binding]; other site 216432006613 Na+ binding site [ion binding]; other site 216432006614 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 216432006615 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216432006616 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 216432006617 16S/18S rRNA binding site [nucleotide binding]; other site 216432006618 S13e-L30e interaction site [polypeptide binding]; other site 216432006619 25S rRNA binding site [nucleotide binding]; other site 216432006620 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 216432006621 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 216432006622 RNase E interface [polypeptide binding]; other site 216432006623 trimer interface [polypeptide binding]; other site 216432006624 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 216432006625 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 216432006626 RNase E interface [polypeptide binding]; other site 216432006627 trimer interface [polypeptide binding]; other site 216432006628 active site 216432006629 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 216432006630 putative nucleic acid binding region [nucleotide binding]; other site 216432006631 G-X-X-G motif; other site 216432006632 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 216432006633 RNA binding site [nucleotide binding]; other site 216432006634 domain interface; other site 216432006635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432006636 non-specific DNA binding site [nucleotide binding]; other site 216432006637 salt bridge; other site 216432006638 sequence-specific DNA binding site [nucleotide binding]; other site 216432006639 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 216432006640 malate synthase A; Region: malate_syn_A; TIGR01344 216432006641 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 216432006642 active site 216432006643 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216432006644 tetramer interface [polypeptide binding]; other site 216432006645 active site 216432006646 Mg2+/Mn2+ binding site [ion binding]; other site 216432006647 active site 216432006648 metal binding site [ion binding]; metal-binding site 216432006649 isocitrate lyase; Region: PLN02892 216432006650 GH3 auxin-responsive promoter; Region: GH3; pfam03321 216432006651 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216432006652 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 216432006653 catalytic triad [active] 216432006654 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 216432006655 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 216432006656 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216432006657 Cytochrome c; Region: Cytochrom_C; pfam00034 216432006658 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 216432006659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216432006660 ATP binding site [chemical binding]; other site 216432006661 putative Mg++ binding site [ion binding]; other site 216432006662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216432006663 nucleotide binding region [chemical binding]; other site 216432006664 ATP-binding site [chemical binding]; other site 216432006665 RQC domain; Region: RQC; pfam09382 216432006666 HRDC domain; Region: HRDC; pfam00570 216432006667 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 216432006668 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 216432006669 putative active site [active] 216432006670 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 216432006671 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 216432006672 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216432006673 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 216432006674 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 216432006675 Walker A/P-loop; other site 216432006676 ATP binding site [chemical binding]; other site 216432006677 Q-loop/lid; other site 216432006678 ABC transporter signature motif; other site 216432006679 Walker B; other site 216432006680 D-loop; other site 216432006681 H-loop/switch region; other site 216432006682 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 216432006683 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 216432006684 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 216432006685 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 216432006686 putative active site [active] 216432006687 catalytic triad [active] 216432006688 putative dimer interface [polypeptide binding]; other site 216432006689 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 216432006690 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216432006691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432006692 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216432006693 O-Antigen ligase; Region: Wzy_C; pfam04932 216432006694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432006695 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 216432006696 putative ADP-binding pocket [chemical binding]; other site 216432006697 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216432006698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432006699 active site 216432006700 phosphorylation site [posttranslational modification] 216432006701 intermolecular recognition site; other site 216432006702 dimerization interface [polypeptide binding]; other site 216432006703 LytTr DNA-binding domain; Region: LytTR; smart00850 216432006704 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216432006705 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 216432006706 Probable Catalytic site; other site 216432006707 metal-binding site 216432006708 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432006709 ligand binding site [chemical binding]; other site 216432006710 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 216432006711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216432006712 putative substrate translocation pore; other site 216432006713 Peptidase family M48; Region: Peptidase_M48; pfam01435 216432006714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 216432006715 salt bridge; other site 216432006716 non-specific DNA binding site [nucleotide binding]; other site 216432006717 sequence-specific DNA binding site [nucleotide binding]; other site 216432006718 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216432006719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432006720 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 216432006721 SelR domain; Region: SelR; pfam01641 216432006722 methionine sulfoxide reductase B; Provisional; Region: PRK00222 216432006723 SelR domain; Region: SelR; pfam01641 216432006724 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 216432006725 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 216432006726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432006727 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216432006728 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216432006729 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 216432006730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216432006731 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216432006732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216432006733 DNA binding residues [nucleotide binding] 216432006734 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 216432006735 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 216432006736 substrate binding site [chemical binding]; other site 216432006737 hexamer interface [polypeptide binding]; other site 216432006738 metal binding site [ion binding]; metal-binding site 216432006739 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 216432006740 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216432006741 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 216432006742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216432006743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216432006744 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 216432006745 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 216432006746 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 216432006747 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216432006748 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 216432006749 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216432006750 putative ligand binding site [chemical binding]; other site 216432006751 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216432006752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216432006753 ABC-ATPase subunit interface; other site 216432006754 dimer interface [polypeptide binding]; other site 216432006755 putative PBP binding regions; other site 216432006756 hypothetical protein; Provisional; Region: PRK12378 216432006757 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 216432006758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216432006759 Histidine kinase; Region: HisKA_3; pfam07730 216432006760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432006761 ATP binding site [chemical binding]; other site 216432006762 Mg2+ binding site [ion binding]; other site 216432006763 G-X-G motif; other site 216432006764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216432006765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432006766 active site 216432006767 phosphorylation site [posttranslational modification] 216432006768 intermolecular recognition site; other site 216432006769 dimerization interface [polypeptide binding]; other site 216432006770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216432006771 dimerization interface [polypeptide binding]; other site 216432006772 DNA binding residues [nucleotide binding] 216432006773 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 216432006774 methionine gamma-lyase; Region: PLN02242 216432006775 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432006776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216432006777 catalytic residue [active] 216432006778 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216432006779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216432006780 dimerization interface [polypeptide binding]; other site 216432006781 putative DNA binding site [nucleotide binding]; other site 216432006782 putative Zn2+ binding site [ion binding]; other site 216432006783 AsnC family; Region: AsnC_trans_reg; pfam01037 216432006784 DNA polymerase III subunit beta; Validated; Region: PRK05643 216432006785 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 216432006786 putative DNA binding surface [nucleotide binding]; other site 216432006787 dimer interface [polypeptide binding]; other site 216432006788 beta-clamp/clamp loader binding surface; other site 216432006789 beta-clamp/translesion DNA polymerase binding surface; other site 216432006790 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216432006791 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216432006792 N-terminal plug; other site 216432006793 ligand-binding site [chemical binding]; other site 216432006794 Tic20-like protein; Region: Tic20; pfam09685 216432006795 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 216432006796 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 216432006797 trmE is a tRNA modification GTPase; Region: trmE; cd04164 216432006798 G1 box; other site 216432006799 GTP/Mg2+ binding site [chemical binding]; other site 216432006800 Switch I region; other site 216432006801 G2 box; other site 216432006802 Switch II region; other site 216432006803 G3 box; other site 216432006804 G4 box; other site 216432006805 G5 box; other site 216432006806 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 216432006807 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 216432006808 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216432006809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216432006810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432006811 non-specific DNA binding site [nucleotide binding]; other site 216432006812 salt bridge; other site 216432006813 sequence-specific DNA binding site [nucleotide binding]; other site 216432006814 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 216432006815 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 216432006816 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216432006817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216432006818 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 216432006819 ligand binding site [chemical binding]; other site 216432006820 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216432006821 non-specific DNA interactions [nucleotide binding]; other site 216432006822 DNA binding site [nucleotide binding] 216432006823 sequence specific DNA binding site [nucleotide binding]; other site 216432006824 putative cAMP binding site [chemical binding]; other site 216432006825 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216432006826 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216432006827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216432006828 active site residue [active] 216432006829 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216432006830 active site residue [active] 216432006831 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 216432006832 Predicted transporter component [General function prediction only]; Region: COG2391 216432006833 Sulphur transport; Region: Sulf_transp; pfam04143 216432006834 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 216432006835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216432006836 motif II; other site 216432006837 CheB methylesterase; Region: CheB_methylest; pfam01339 216432006838 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216432006839 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 216432006840 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 216432006841 PAS domain; Region: PAS_10; pfam13596 216432006842 PAS domain; Region: PAS_9; pfam13426 216432006843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432006844 dimer interface [polypeptide binding]; other site 216432006845 phosphorylation site [posttranslational modification] 216432006846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432006847 ATP binding site [chemical binding]; other site 216432006848 Mg2+ binding site [ion binding]; other site 216432006849 G-X-G motif; other site 216432006850 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 216432006851 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 216432006852 putative catalytic cysteine [active] 216432006853 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 216432006854 nucleotide binding site [chemical binding]; other site 216432006855 homotetrameric interface [polypeptide binding]; other site 216432006856 putative phosphate binding site [ion binding]; other site 216432006857 putative allosteric binding site; other site 216432006858 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216432006859 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 216432006860 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 216432006861 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 216432006862 metal binding site [ion binding]; metal-binding site 216432006863 dimer interface [polypeptide binding]; other site 216432006864 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 216432006865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432006866 active site 216432006867 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 216432006868 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 216432006869 active site 216432006870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432006871 Amidohydrolase; Region: Amidohydro_4; pfam13147 216432006872 active site 216432006873 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 216432006874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216432006875 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 216432006876 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 216432006877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216432006878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432006879 Coenzyme A binding pocket [chemical binding]; other site 216432006880 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 216432006881 catalytic motif [active] 216432006882 Zn binding site [ion binding]; other site 216432006883 RibD C-terminal domain; Region: RibD_C; pfam01872 216432006884 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 216432006885 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 216432006886 Uncharacterized conserved protein [Function unknown]; Region: COG1739 216432006887 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 216432006888 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216432006889 active site 216432006890 DnaA N-terminal domain; Region: DnaA_N; pfam11638 216432006891 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 216432006892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432006893 Walker A motif; other site 216432006894 ATP binding site [chemical binding]; other site 216432006895 Walker B motif; other site 216432006896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 216432006897 arginine finger; other site 216432006898 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 216432006899 DnaA box-binding interface [nucleotide binding]; other site 216432006900 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 216432006901 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216432006902 active site 216432006903 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 216432006904 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432006905 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 216432006906 putative SAM binding site [chemical binding]; other site 216432006907 homodimer interface [polypeptide binding]; other site 216432006908 YceG-like family; Region: YceG; pfam02618 216432006909 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 216432006910 dimerization interface [polypeptide binding]; other site 216432006911 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216432006912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432006913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216432006914 Coenzyme A binding pocket [chemical binding]; other site 216432006915 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 216432006916 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216432006917 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216432006918 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 216432006919 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216432006920 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216432006921 protein binding site [polypeptide binding]; other site 216432006922 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 216432006923 protein binding site [polypeptide binding]; other site 216432006924 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 216432006925 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 216432006926 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216432006927 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 216432006928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216432006929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216432006930 Coenzyme A binding pocket [chemical binding]; other site 216432006931 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216432006932 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216432006933 Walker A/P-loop; other site 216432006934 ATP binding site [chemical binding]; other site 216432006935 Q-loop/lid; other site 216432006936 ABC transporter signature motif; other site 216432006937 Walker B; other site 216432006938 D-loop; other site 216432006939 H-loop/switch region; other site 216432006940 DNA recombination protein RmuC; Provisional; Region: PRK10361 216432006941 RmuC family; Region: RmuC; pfam02646 216432006942 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 216432006943 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432006944 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 216432006945 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216432006946 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216432006947 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 216432006948 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 216432006949 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216432006950 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 216432006951 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216432006952 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 216432006953 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216432006954 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432006955 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216432006956 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 216432006957 TrkA-C domain; Region: TrkA_C; pfam02080 216432006958 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 216432006959 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216432006960 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 216432006961 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 216432006962 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 216432006963 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 216432006964 putative active site [active] 216432006965 catalytic site [active] 216432006966 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 216432006967 putative active site [active] 216432006968 catalytic site [active] 216432006969 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216432006970 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216432006971 catalytic residue [active] 216432006972 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432006973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432006974 S-adenosylmethionine binding site [chemical binding]; other site 216432006975 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216432006976 Ligand binding site; other site 216432006977 Putative Catalytic site; other site 216432006978 DXD motif; other site 216432006979 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432006980 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432006981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216432006982 TPR motif; other site 216432006983 TPR repeat; Region: TPR_11; pfam13414 216432006984 binding surface 216432006985 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 216432006986 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cd12213 216432006987 ligand binding site [chemical binding]; other site 216432006988 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216432006989 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216432006990 Walker A/P-loop; other site 216432006991 ATP binding site [chemical binding]; other site 216432006992 Q-loop/lid; other site 216432006993 ABC transporter signature motif; other site 216432006994 Walker B; other site 216432006995 D-loop; other site 216432006996 H-loop/switch region; other site 216432006997 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 216432006998 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 216432006999 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 216432007000 Glutamate binding site [chemical binding]; other site 216432007001 NAD binding site [chemical binding]; other site 216432007002 catalytic residues [active] 216432007003 Preprotein translocase subunit; Region: YajC; pfam02699 216432007004 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 216432007005 transcription antitermination factor NusB; Region: nusB; TIGR01951 216432007006 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 216432007007 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216432007008 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 216432007009 NAD binding site [chemical binding]; other site 216432007010 Phe binding site; other site 216432007011 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216432007012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216432007013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216432007014 Walker A/P-loop; other site 216432007015 ATP binding site [chemical binding]; other site 216432007016 Q-loop/lid; other site 216432007017 ABC transporter signature motif; other site 216432007018 Walker B; other site 216432007019 D-loop; other site 216432007020 H-loop/switch region; other site 216432007021 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 216432007022 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 216432007023 putative active site [active] 216432007024 Zn binding site [ion binding]; other site 216432007025 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216432007026 putative hydrophobic ligand binding site [chemical binding]; other site 216432007027 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216432007028 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216432007029 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216432007030 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216432007031 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216432007032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216432007033 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216432007034 DNA-binding site [nucleotide binding]; DNA binding site 216432007035 RNA-binding motif; other site 216432007036 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 216432007037 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 216432007038 putative trimer interface [polypeptide binding]; other site 216432007039 putative CoA binding site [chemical binding]; other site 216432007040 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 216432007041 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 216432007042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432007043 putative ADP-binding pocket [chemical binding]; other site 216432007044 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 216432007045 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 216432007046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432007047 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 216432007048 putative ADP-binding pocket [chemical binding]; other site 216432007049 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216432007050 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216432007051 trimer interface [polypeptide binding]; other site 216432007052 active site 216432007053 substrate binding site [chemical binding]; other site 216432007054 CoA binding site [chemical binding]; other site 216432007055 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 216432007056 dimer interface [polypeptide binding]; other site 216432007057 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 216432007058 active site 216432007059 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 216432007060 Ligand Binding Site [chemical binding]; other site 216432007061 Molecular Tunnel; other site 216432007062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216432007063 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 216432007064 putative ADP-binding pocket [chemical binding]; other site 216432007065 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 216432007066 pseudaminic acid synthase; Region: PseI; TIGR03586 216432007067 NeuB family; Region: NeuB; pfam03102 216432007068 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 216432007069 NeuB binding interface [polypeptide binding]; other site 216432007070 putative substrate binding site [chemical binding]; other site 216432007071 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 216432007072 dimer interaction site [polypeptide binding]; other site 216432007073 substrate-binding tunnel; other site 216432007074 active site 216432007075 catalytic site [active] 216432007076 substrate binding site [chemical binding]; other site 216432007077 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 216432007078 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216432007079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 216432007080 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 216432007081 ligand binding site; other site 216432007082 tetramer interface; other site 216432007083 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216432007084 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216432007085 inhibitor-cofactor binding pocket; inhibition site 216432007086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432007087 catalytic residue [active] 216432007088 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 216432007089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216432007090 NAD(P) binding site [chemical binding]; other site 216432007091 active site 216432007092 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216432007093 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216432007094 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 216432007095 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216432007096 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216432007097 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 216432007098 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 216432007099 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 216432007100 NAD binding site [chemical binding]; other site 216432007101 substrate binding site [chemical binding]; other site 216432007102 homodimer interface [polypeptide binding]; other site 216432007103 active site 216432007104 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 216432007105 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216432007106 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 216432007107 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 216432007108 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 216432007109 active site 216432007110 homodimer interface [polypeptide binding]; other site 216432007111 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 216432007112 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 216432007113 substrate binding site; other site 216432007114 tetramer interface; other site 216432007115 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 216432007116 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 216432007117 NADP binding site [chemical binding]; other site 216432007118 active site 216432007119 putative substrate binding site [chemical binding]; other site 216432007120 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 216432007121 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 216432007122 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 216432007123 NAD binding site [chemical binding]; other site 216432007124 substrate binding site [chemical binding]; other site 216432007125 homodimer interface [polypeptide binding]; other site 216432007126 active site 216432007127 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216432007128 active site 216432007129 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 216432007130 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 216432007131 Na binding site [ion binding]; other site 216432007132 Family of unknown function (DUF490); Region: DUF490; pfam04357 216432007133 Family of unknown function (DUF490); Region: DUF490; pfam04357 216432007134 UGMP family protein; Validated; Region: PRK09604 216432007135 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 216432007136 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 216432007137 RNA methyltransferase, RsmE family; Region: TIGR00046 216432007138 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 216432007139 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 216432007140 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216432007141 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216432007142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216432007143 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 216432007144 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216432007145 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 216432007146 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 216432007147 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 216432007148 dimerization interface [polypeptide binding]; other site 216432007149 DPS ferroxidase diiron center [ion binding]; other site 216432007150 ion pore; other site 216432007151 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216432007152 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216432007153 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216432007154 active site 216432007155 metal binding site [ion binding]; metal-binding site 216432007156 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216432007157 Surface antigen; Region: Bac_surface_Ag; pfam01103 216432007158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216432007159 Zn2+ binding site [ion binding]; other site 216432007160 Mg2+ binding site [ion binding]; other site 216432007161 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 216432007162 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432007163 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432007164 catalytic residues [active] 216432007165 Uncharacterized conserved protein [Function unknown]; Region: COG2968 216432007166 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 216432007167 Rhomboid family; Region: Rhomboid; pfam01694 216432007168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216432007169 putative acyl-acceptor binding pocket; other site 216432007170 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 216432007171 dimer interface [polypeptide binding]; other site 216432007172 substrate binding site [chemical binding]; other site 216432007173 metal binding sites [ion binding]; metal-binding site 216432007174 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 216432007175 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432007176 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432007177 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 216432007178 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 216432007179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216432007180 RNA binding surface [nucleotide binding]; other site 216432007181 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 216432007182 probable active site [active] 216432007183 transcription termination factor Rho; Provisional; Region: rho; PRK09376 216432007184 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 216432007185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216432007186 putative metal binding site [ion binding]; other site 216432007187 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216432007188 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216432007189 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 216432007190 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 216432007191 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 216432007192 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432007193 Cna protein B-type domain; Region: Cna_B_2; pfam13715 216432007194 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216432007195 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216432007196 alpha subunit interface [polypeptide binding]; other site 216432007197 TPP binding site [chemical binding]; other site 216432007198 heterodimer interface [polypeptide binding]; other site 216432007199 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216432007200 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216432007201 Ligand binding site [chemical binding]; other site 216432007202 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216432007203 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216432007204 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 216432007205 Ligand Binding Site [chemical binding]; other site 216432007206 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216432007207 Bifunctional nuclease; Region: DNase-RNase; pfam02577 216432007208 UvrB/uvrC motif; Region: UVR; pfam02151 216432007209 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 216432007210 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 216432007211 Nucleoside recognition; Region: Gate; pfam07670 216432007212 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 216432007213 thymidylate synthase; Reviewed; Region: thyA; PRK01827 216432007214 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 216432007215 dimerization interface [polypeptide binding]; other site 216432007216 active site 216432007217 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 216432007218 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 216432007219 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216432007220 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 216432007221 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 216432007222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216432007223 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216432007224 Domain of unknown function (DUF427); Region: DUF427; pfam04248 216432007225 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216432007226 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216432007227 2TM domain; Region: 2TM; pfam13239 216432007228 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 216432007229 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 216432007230 folate binding site [chemical binding]; other site 216432007231 NADP+ binding site [chemical binding]; other site 216432007232 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 216432007233 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216432007234 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 216432007235 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216432007236 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 216432007237 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 216432007238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216432007239 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 216432007240 active site 216432007241 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216432007242 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216432007243 inhibitor-cofactor binding pocket; inhibition site 216432007244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216432007245 catalytic residue [active] 216432007246 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 216432007247 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 216432007248 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 216432007249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216432007250 non-specific DNA binding site [nucleotide binding]; other site 216432007251 salt bridge; other site 216432007252 sequence-specific DNA binding site [nucleotide binding]; other site 216432007253 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 216432007254 Catalytic site [active] 216432007255 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216432007256 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 216432007257 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 216432007258 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 216432007259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216432007260 active site 216432007261 Lamin Tail Domain; Region: LTD; pfam00932 216432007262 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 216432007263 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 216432007264 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216432007265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216432007266 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216432007267 active site 216432007268 phosphorylation site [posttranslational modification] 216432007269 intermolecular recognition site; other site 216432007270 dimerization interface [polypeptide binding]; other site 216432007271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216432007272 Walker A motif; other site 216432007273 ATP binding site [chemical binding]; other site 216432007274 Walker B motif; other site 216432007275 arginine finger; other site 216432007276 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216432007277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216432007278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216432007279 dimer interface [polypeptide binding]; other site 216432007280 phosphorylation site [posttranslational modification] 216432007281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216432007282 ATP binding site [chemical binding]; other site 216432007283 Mg2+ binding site [ion binding]; other site 216432007284 G-X-G motif; other site 216432007285 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 216432007286 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 216432007287 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 216432007288 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 216432007289 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 216432007290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216432007291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216432007292 S-adenosylmethionine binding site [chemical binding]; other site 216432007293 triosephosphate isomerase; Provisional; Region: PRK14565 216432007294 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 216432007295 substrate binding site [chemical binding]; other site 216432007296 dimer interface [polypeptide binding]; other site 216432007297 catalytic triad [active] 216432007298 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216432007299 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216432007300 catalytic residues [active] 216432007301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216432007302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216432007303 dimer interface [polypeptide binding]; other site 216432007304 conserved gate region; other site 216432007305 putative PBP binding loops; other site 216432007306 ABC-ATPase subunit interface; other site 216432007307 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 216432007308 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 216432007309 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216432007310 dihydropteroate synthase; Region: DHPS; TIGR01496 216432007311 substrate binding pocket [chemical binding]; other site 216432007312 dimer interface [polypeptide binding]; other site 216432007313 inhibitor binding site; inhibition site 216432007314 Uncharacterized conserved protein [Function unknown]; Region: COG1624 216432007315 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 216432007316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216432007317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216432007318 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 216432007319 Walker A/P-loop; other site 216432007320 ATP binding site [chemical binding]; other site 216432007321 Q-loop/lid; other site 216432007322 ABC transporter signature motif; other site 216432007323 Walker B; other site 216432007324 D-loop; other site 216432007325 H-loop/switch region; other site 216432007326 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 216432007327 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 216432007328 dimerization interface 3.5A [polypeptide binding]; other site 216432007329 active site 216432007330 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 216432007331 active site 216432007332 metal binding site [ion binding]; metal-binding site 216432007333 homotetramer interface [polypeptide binding]; other site 216432007334 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 216432007335 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216432007336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216432007337 FeS/SAM binding site; other site 216432007338 Beta-lactamase; Region: Beta-lactamase; pfam00144 216432007339 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216432007340 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 216432007341 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216432007342 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 216432007343 ribosomal protein L33; Region: rpl33; CHL00104 216432007344 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 216432007345 competence damage-inducible protein A; Provisional; Region: PRK00549 216432007346 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 216432007347 putative MPT binding site; other site 216432007348 Competence-damaged protein; Region: CinA; pfam02464 216432007349 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216432007350 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216432007351 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216432007352 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 216432007353 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216432007354 active site 216432007355 catalytic site [active] 216432007356 substrate binding site [chemical binding]; other site 216432007357 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; cl00815 216432007358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216432007359 active site 216432007360 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 216432007361 active site 216432007362 dimer interface [polypeptide binding]; other site 216432007363 peptide chain release factor 1; Validated; Region: prfA; PRK00591 216432007364 PCRF domain; Region: PCRF; pfam03462 216432007365 RF-1 domain; Region: RF-1; pfam00472 216432007366 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 216432007367 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 216432007368 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 216432007369 dimerization interface [polypeptide binding]; other site 216432007370 ATP binding site [chemical binding]; other site 216432007371 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 216432007372 active site 216432007373 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 216432007374 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 216432007375 active site 216432007376 metal binding site [ion binding]; metal-binding site 216432007377 nudix motif; other site 216432007378 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216432007379 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216432007380 ligand binding site [chemical binding]; other site 216432007381 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 216432007382 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585